The Ph.D. Program for Translational Medicine

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output 1995 2019

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2014
29 Citations (Scopus)

Crowning proteins: Modulating the protein surface properties using crown ethers

Lee, C. C., Maestre-Reyna, M., Hsu, K. C., Wang, H. C., Liu, C. I., Jeng, W. Y., Lin, L. L., Wood, R., Chou, C. C., Yang, J. M. & Wang, A. H. J., Nov 24 2014, In : Angewandte Chemie - International Edition. 53, 48, p. 13054-13058 5 p.

Research output: Contribution to journalArticle

Crown Ethers
Crown ethers
Surface properties
Proteins
Membrane Proteins
21 Citations (Scopus)

Delayed animal aging through the recovery of stem cell senescence by platelet rich plasma

Liu, H. Y., Huang, C. F., Lin, T. C., Tsai, C. Y., Tina Chen, S. Y., Liu, A., Chen, W. H., Wei, H. J., Wang, M. F., Williams, D. F. & Deng, W. P., Dec 1 2014, In : Biomaterials. 35, 37, p. 9767-9776 10 p.

Research output: Contribution to journalArticle

Platelet-Rich Plasma
Cell Aging
Platelets
Stem cells
Animals
20 Citations (Scopus)

Destruxin B inhibits hepatocellular carcinoma cell growth through modulation of the Wnt/β-catenin signaling pathway and epithelial-mesenchymal transition

Huynh, T. T., Rao, Y. K., Lee, W. H., Chen, H. A., Le, T. D. Q., Tzeng, D. T. W., Wang, L. S., Wu, A. T. H., Lin, Y. F., Tzeng, Y. M. & Yeh, C-T., Jun 2014, In : Toxicology in Vitro. 28, 4, p. 552-561 10 p.

Research output: Contribution to journalArticle

Catenins
Wnt Signaling Pathway
Epithelial-Mesenchymal Transition
Cell growth
Hepatocellular Carcinoma
9 Citations (Scopus)

Development of a growth-hormone-conjugated nanodiamond complex for cancer therapy

Chu, H. L., Chen, H. W., Tseng, S. H., Hsu, M. H., Ho, L. P., Chou, F. H., Li, M. P. H. Y., Chang, Y. C., Chen, P. H., Tsai, L. Y., Chou, C. C., Chen, J. S., Cheng, T. M. & Chang, C. C., 2014, In : ChemMedChem. 9, 5, p. 1023-1029 7 p.

Research output: Contribution to journalArticle

Nanodiamonds
Growth Hormone
Cells
Lasers
Somatotropin Receptors
4 Citations (Scopus)

Disease universe: Visualisation of population-wide disease-wide associations

Moldovan, M., Enikeev, R., Syed-Abdul, S., Nguyen, P. A., Chang, Y-C. & Li, Y. C., 2014, In : Advances in Systems Science and Applications. 14, 2, p. 144-158 15 p.

Research output: Contribution to journalArticle

Visualization
Health
20 Citations (Scopus)

Dovitinib synergizes with oxaliplatin in suppressing cell proliferation and inducing apoptosis in colorectal cancer cells regardless of RAS-RAF mutation status

Gaur, S., Chen, L., Ann, V., Lin, W. C., Wang, Y., Chang, V. H. S., Hsu, N. Y., Shia, H. S. & Yen, Y., Feb 4 2014, In : Molecular Cancer. 13, 1, 21.

Research output: Contribution to journalArticle

oxaliplatin
Colorectal Neoplasms
Cell Proliferation
Heterografts
Colonic Neoplasms
3 Citations (Scopus)

Emergency department utilization can indicate early diagnosis of digestive tract cancers: A population-based study in Taiwan

Lam, C., Kuan, C. F., Miser, J., Hsieh, K. Y., Fang, Y. A., Li, Y-C., Hsu, C-W., Chen, R-J. & Chen, C-I., 2014, In : Computer Methods and Programs in Biomedicine. 115, 3, p. 103-109 7 p.

Research output: Contribution to journalArticle

Taiwan
Gastrointestinal Tract
Hospital Emergency Service
Early Diagnosis
Blood
24 Citations (Scopus)

Empowering village doctors and enhancing rural healthcare using cloud computing in a rural area of mainland China

Lin, C-W., Abdul, S. S., Clinciu, D. L., Scholl, J., Jin, X., Lu, H., Chen, S. S., Iqbal, U., Heineck, M. J. & Li, Y. C., Feb 2014, In : Computer Methods and Programs in Biomedicine. 113, 2, p. 585-592 8 p.

Research output: Contribution to journalArticle

Electronic Health Records
Cloud computing
China
Preventive Medicine
Health
22 Citations (Scopus)

Establishment of a promising human nucleus pulposus cell line for intervertebral disc tissue engineering

Liu, M. C., Chen, W. H., Wu, L. C., Hsu, W. C., Lo, W. C., Yeh, S. D., Wang, M. F., Zeng, R. & Deng, W. P., Jan 1 2014, In : Tissue Engineering - Part C: Methods. 20, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

Intervertebral Disc
Tissue Engineering
Platelets
Tissue engineering
Cells
40 Citations (Scopus)

FOXF1 mediates mesenchymal stem cell fusion-induced reprogramming of lung cancer cells

Wei, H. J., Nickoloff, J. A., Chen, W. H., Liu, H. Y., Lo, W. C., Chang, Y. T., Yang, P. C., Wu, C. W., Williams, D. F., Gelovani, J. G. & Deng, W. P., 2014, In : Oncotarget. 5, 19, p. 9514-9529 16 p.

Research output: Contribution to journalArticle

Cell Fusion
Mesenchymal Stromal Cells
Lung Neoplasms
Tumor Microenvironment
Neoplasms
15 Citations (Scopus)

Galectin-1 induces vascular permeability through the neuropilin-1/vascular endothelial growth factor receptor-1 complex

Wu, M. H., Ying, N. W., Hong, T. M., Chiang, W. F., Lin, Y. T. & Chen, Y. L., Oct 1 2014, In : Angiogenesis. 17, 4, p. 839-849 11 p.

Research output: Contribution to journalArticle

Neuropilin-1
Galectin 1
Vascular Endothelial Growth Factor Receptor-1
Capillary Permeability
Tumors
11 Citations (Scopus)

Potential drug-drug interactions in pediatric outpatient prescriptions for newborns and infants

Yeh, M. L., Chang, Y. J., Yeh, S. J., Huang, L. J., Yen, Y. T., Wang, P. Y., Li, Y. C. & Hsu, C-Y., Jan 2014, In : Computer Methods and Programs in Biomedicine. 113, 1, p. 15-22 8 p.

Research output: Contribution to journalArticle

Drug interactions
Pediatrics
Drug Interactions
Prescriptions
Outpatients
19 Citations (Scopus)

Staphylococcus aureus protein SAUGI acts as a uracil-DNA glycosylase inhibitor

Wang, H. C., Hsu, K. C., Yang, J. M., Wu, M. L., Ko, T. P., Lin, S. R. & Wang, A. H. J., 2014, In : Nucleic Acids Research. 42, 2, p. 1354-1364 11 p.

Research output: Contribution to journalArticle

Uracil-DNA Glycosidase
Protein S
Staphylococcus aureus
DNA
Proteins
11 Citations (Scopus)

Structural analysis of poly-SUMO chain recognition by the RNF4-SIMs domain

Kung, C. C. H., Naik, M. T., Wang, S. H., Shih, H. M., Chang, C. C., Lin, L. Y., Chen, C. L., Ma, C., Chang, C. F. & Huang, T. H., Jul 15 2014, In : Biochemical Journal. 462, 1, p. 53-65 13 p.

Research output: Contribution to journalArticle

Structural analysis
Proteins
Small Ubiquitin-Related Modifier Proteins
Ubiquitin-Protein Ligases
Ubiquitin
47 Citations (Scopus)

Synergistic anabolic actions of hyaluronic acid and platelet-rich plasma on cartilage regeneration in osteoarthritis therapy

Chen, W. H., Lo, W-C., Hsu, W. C., Wei, H. J., Liu, H. Y., Lee, C-H., Tina Chen, S. Y., Shieh, Y-H., Williams, D. F. & Deng, W-P., 2014, In : Biomaterials. 35, 36, p. 9599-9607 9 p.

Research output: Contribution to journalArticle

Hyaluronic acid
Platelet-Rich Plasma
Cartilage
Hyaluronic Acid
Platelets
12 Citations (Scopus)

Targeting L1 cell adhesion molecule expression using liposomeencapsulated siRNA suppresses prostate cancer bone metastasis and growth

Sung, S. Y., Wu, I. H., Chuang, P. H., Petros, J. A., Wu, H. C., Zeng, H. J., Huang, W. C., Chung, L. W. K. & Hsieh, C. L., 2014, In : Oncotarget. 5, 20, p. 9911-9929 19 p.

Research output: Contribution to journalArticle

Neural Cell Adhesion Molecule L1
Bone Neoplasms
Bone Development
Small Interfering RNA
Prostatic Neoplasms
13 Citations (Scopus)

The dermoscopic comma, zigzag, and bar code-like hairs: Markers of fungal infection of the hair follicles

Lin, Y. T. & Li, Y. C., 2014, In : Dermatologica Sinica. 32, 3, p. 160-163 4 p.

Research output: Contribution to journalArticle

Hair Follicle
Mycoses
Automatic Data Processing
Hair
Tinea Capitis

The health database in an information society

Li, Y. C. J., 2014, In : Japan Medical Association Journal. 57, 4, p. 216-221 6 p.

Research output: Contribution to journalArticle

Databases
Health
4 Citations (Scopus)

Thermal stability and folding kinetics analysis of disordered protein, securin

Chu, H. L., Chen, T. H., Wu, C. Y., Yang, Y. C., Tseng, S. H., Cheng, T. M., Ho, L. P., Tsai, L. Y., Li, H. Y., Chang, C. S. & Chang, C. C., Mar 2014, In : Journal of Thermal Analysis and Calorimetry. 115, 3, p. 2171-2178 8 p.

Research output: Contribution to journalArticle

Securin
folding
Thermodynamic stability
thermal stability
proteins
12 Citations (Scopus)

The T4 phage DNA mimic protein arn inhibits the DNA binding activity of the bacterial histone-like protein H-NS

Ho, C. H., Wang, H. C., Ko, T. P., Chang, Y. C. & Wang, A. H. J., Sep 26 2014, In : Journal of Biological Chemistry. 289, 39, p. 27046-27054 9 p.

Research output: Contribution to journalArticle

Bacteriophage T4
Bacteriophages
Histones
DNA
Proteins
18 Citations (Scopus)

Wnts enhance neurotrophin-induced neuronal differentiation in adult bone-marrow-derived mesenchymal stem cells via canonical and noncanonical signaling pathways

Tsai, H. L., Deng, W. P., Lai, W-F. T., Chiu, W. T., Yang, C. B., Tsai, Y. H., Hwang, S. M. & Renshaw, P. F., Aug 29 2014, In : PLoS One. 9, 8, e104937.

Research output: Contribution to journalArticle

neurotrophins
Nerve Growth Factors
Stem cells
Mesenchymal Stromal Cells
bone marrow
2013
4 Citations (Scopus)

A method to manage and share anti-retroviral (ARV) therapy information of human immunodeficiency virus (HIV) patients in Vietnam

Nguyen, P. A., Syed-Abdul, S., Minamareddy, P., Lee, P., Ngo, T. D., Iqbal, U., Nguyen, P. H., Jian, W. S. & Li, Y. C. J., Aug 2013, In : Computer Methods and Programs in Biomedicine. 111, 2, p. 290-299 10 p.

Research output: Contribution to journalArticle

Vietnam
Viruses
HIV
Delivery of Health Care
Health care
3 Citations (Scopus)
Feasibility Studies
examination
university
methodology
Students
24 Citations (Scopus)

Application of galactose-modified liposomes as a potent antigen presenting cell targeted carrier for intranasal immunization

Wang, H. W., Jiang, P. L., Lin, S. F., Lin, H. J., Ou, K. L., Deng, W. P., Lee, L. W., Huang, Y. Y., Liang, P. H. & Liu, D. Z., Mar 2013, In : Acta Biomaterialia. 9, 3, p. 5681-5688 8 p.

Research output: Contribution to journalArticle

Immunization
Liposomes
Antigen-Presenting Cells
Galactose
Ovalbumin
17 Citations (Scopus)

A preclinical evaluation of antimycin a as a potential antilung cancer stem cell agent

Yeh, C-T., Su, C. L., Huang, C. Y. F., Lin, J. K. Y., Lee, W. H., Chang, P. M. H., Kuo, Y. L., Liu, Y. W., Wang, L. S., Wu, C. H., Shieh, Y. S., Jan, Y. H., Chuang, Y. J., Hsiao, M. & Wu, A. T. H., 2013, In : Evidence-based Complementary and Alternative Medicine. 2013, 910451.

Research output: Contribution to journalArticle

Antimycin A
Neoplastic Stem Cells
Side-Population Cells
Lung Neoplasms
Catenins
13 Citations (Scopus)

A probabilistic model for reducing medication errors

Nguyen, P. A., Syed-Abdul, S., Iqbal, U., Hsu, M-H., Huang, C-L., Li, H-C., Clinciu, D. L., Jian, W. S. & Li, Y. C. J., Dec 3 2013, In : PLoS One. 8, 12, e82401.

Research output: Contribution to journalArticle

probabilistic models
Medication Errors
Statistical Models
drug therapy
Prescriptions
46 Citations (Scopus)

A sesquiterpene lactone antrocin from Antrodia camphorata negatively modulates JAK2/STAT3 signaling via microRNA let-7c and induces apoptosis in lung cancer cells

Yeh, C-T., Huang, W. C., Rao, Y. K., Ye, M., Lee, W. H., Wang, L. S., Tzeng, D. T. W., Wu, C. H., Shieh, Y. S., Huang, C. Y. F., Chen, Y. J., Hsiao, M., Wu, A. T. H., Yang, Z. & Tzeng, Y. M., Dec 2013, In : Carcinogenesis. 34, 12, p. 2918-2928 11 p.

Research output: Contribution to journalArticle

Antrodia
Sesquiterpenes
Lactones
MicroRNAs
Lung Neoplasms
4 Citations (Scopus)

Association between gout and vertigo in a Taiwanese population

Lin, Y. T., Lin, H. W., Huang, Y-C., Ho, W. T., Li, Y. C. & Chen, T. J., Jun 2013, In : Journal of Clinical Neuroscience. 20, 6, p. 857-861 5 p.

Research output: Contribution to journalArticle

Gout
Vertigo
Population
Cohort Studies
Incidence
16 Citations (Scopus)
Blueberry Plants
Neoplastic Stem Cells
Hepatocellular Carcinoma
Stem Cells
Radiation
120 Citations (Scopus)

Cisplatin selects for multidrug-resistant CD133+ cells in lung adenocarcinoma by activating notch signaling

Liu, Y. P., Yang, C. J., Huang, M. S., Yeh, C-T., Wu, A. T. H., Lee, Y. C., Lai, T. C., Lee, C. H., Hsiao, Y. W., Lu, J., Shen, C. N., Lu, P. J. & Hsiao, M., Jan 1 2013, In : Cancer Research. 73, 1, p. 406-416 11 p.

Research output: Contribution to journalArticle

Cisplatin
Paclitaxel
Drug Resistance
Doxorubicin
Lung Neoplasms
12 Citations (Scopus)

Destabilization of KLF10, a tumor suppressor, relies on thr93 phosphorylation and isomerase association

Hwang, Y. C., Yang, C. H., Lin, C. H., Ch'ang, H. J., Chang, V. H. S. & Yu, W. C. Y., Dec 2013, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 12, p. 3035-3045 11 p.

Research output: Contribution to journalArticle

Isomerases
Phosphorylation
Neoplasms
Proteins
Peptidylprolyl Isomerase
26 Citations (Scopus)

Effects of and satisfaction with short message service reminders for patient medication adherence: A randomized controlled study

Huang, H. L., Li, Y. C. J., Chou, Y. C., Hsieh, Y. W., Kuo, F., Tsai, W. C., Chai, S. D., Lin, B. Y. J., Kung, P. T. & Chuang, C. J., Nov 16 2013, In : BMC Medical Informatics and Decision Making. 13, 1, 127.

Research output: Contribution to journalArticle

Text Messaging
Medication Adherence
Patient Compliance
Control Groups
Appointments and Schedules
36 Citations (Scopus)

Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78

Tsai, H. Y., Yang, Y. F., Wu, A. T., Yang, C. J., Liu, Y. P., Jan, Y. H., Lee, C. H., Hsiao, Y. W., Yeh, C-T., Shen, C. N., Lu, P. J., Huang, M. S. & Hsiao, M., Oct 10 2013, In : Oncogene. 32, 41, p. 4921-4931 11 p.

Research output: Contribution to journalArticle

Reticulum
Ribosomes
Endoplasmic Reticulum
Lung Neoplasms
Carrier Proteins

Erratum: Rapid and highly sensitive detection of Enterovirus 71 by using nanogold-enhanced electrochemical impedance spectroscopy (Nanotechnology (2013) 24 (285102))

Li, H. Y., Tseng, S. H., Cheng, T. M., Chu, H. L., Lu, Y. N., Wang, F. Y., Tsai, L. Y., Shieh, J. Y., Yang, J. Y., Juan, C. C., Tu, L. C. & Chang, C. C., Oct 4 2013, In : Nanotechnology. 24, 39, 399501.

Research output: Contribution to journalArticle

Grouped vesicles on the leg of a 60-year-old woman

Lin, Y. T., Ko, W. L. & Li, Y. C., Jul 2013, In : Journal of the American Academy of Dermatology. 69, 1

Research output: Contribution to journalArticle

Leg
18 Citations (Scopus)
Trophoblasts
Hyperglycemia
Extracellular Matrix
Glycosaminoglycans
Matrix Metalloproteinases
5 Citations (Scopus)

IbACP, a sixteen-amino-acid peptide isolated from Ipomoea batatas leaves, induces carcinoma cell apoptosis

Chang, V. H. S., Yang, D. H. A., Lin, H. H., Pearce, G., Ryan, C. A. & Chen, Y. C., 2013, In : Peptides. 47, p. 148-156 9 p.

Research output: Contribution to journalArticle

Ipomoea batatas
Cells
Apoptosis
Carcinoma
Amino Acids
1 Citation (Scopus)
Chronic Obstructive Pulmonary Disease
Human Influenza
Vaccination
Hospitalization
Heart Failure
12 Citations (Scopus)
Cyclooxygenase 1
Cell Aggregation
Endothelial cells
Platelets
Platelet Aggregation
41 Citations (Scopus)

Loss of let-7 microRNA upregulates IL-6 in bone marrow-derived mesenchymal stem cells triggering a reactive stromal response to prostate cancer.

Sung, S. Y., Liao, C. H., Wu, H. P., Hsiao, W. C., Wu, I. H., Jinpu, Yu, Lin, S. H. & Hsieh, C. L., 2013, In : PLoS One. 8, 8, e71637.

Research output: Contribution to journalArticle

prostatic neoplasms
Stem cells
MicroRNAs
Mesenchymal Stromal Cells
microRNA
125 Citations (Scopus)

Misleading health-related information promoted through video-based social media: Anorexia on youtube

Syed-Abdul, S., Fernandez-Luque, L., Jian, W. S., Li, Y. C., Crain, S., Hsu, M-H., Wang, Y. C., Khandregzen, D., Chuluunbaatar, E., Nguyen, P. A. & Liou, D. M., Feb 2013, In : Journal of Medical Internet Research. 15, 2

Research output: Contribution to journalArticle

Social Media
Anorexia
Health
Beauty
Anorexia Nervosa

Past, present, and future of CMPB

Jack Li, Y. C., Apr 2013, In : Computer Methods and Programs in Biomedicine. 110, 1, p. 1 1 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Physicians' responses to computerized drug-drug interaction alerts for outpatients

Yeh, M. L., Chang, Y. J., Wang, P. Y., Li, Y. C. & Hsu, C-Y., Jul 2013, In : Computer Methods and Programs in Biomedicine. 111, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

Drug interactions
Drug Interactions
Outpatients
Physicians
Pharmaceutical Preparations
18 Citations (Scopus)

Plasma Haptoglobin Concentrations Are Elevated in Patients with Coronary Artery Disease

Lee, C. W., Cheng, T. M., Lin, C. P. & Pan, J. P., Oct 9 2013, In : PLoS One. 8, 10, e76817.

Research output: Contribution to journalArticle

Haptoglobins
haptoglobins
Coronary Artery Disease
Plasmas
odds ratio
15 Citations (Scopus)

Potential osteoporosis recovery by deep sea water through bone regeneration in SAMP8 mice

Liu, H. Y., Liu, M. C., Wang, M. F., Chen, W. H., Tsai, C. Y., Wu, K. H., Lin, C. T., Shieh, Y. H., Zeng, R. & Deng, W. P., 2013, In : Evidence-based Complementary and Alternative Medicine. 2013, 161976.

Research output: Contribution to journalArticle

Bone Regeneration
Seawater
Osteoporosis
Complementary Therapies
Life Expectancy
17 Citations (Scopus)

Preferential therapy for osteoarthritis by cord blood MSCs through regulation of chondrogenic cytokines

Lo, W. C., Chen, W. H., Lin, T. C., Hwang, S. M., Zeng, R., Hsu, W. C., Chiang, Y. M., Liu, M. C., Williams, D. F. & Deng, W. P., Jul 2013, In : Biomaterials. 34, 20, p. 4739-4748 10 p.

Research output: Contribution to journalArticle

Stem cells
Mesenchymal Stromal Cells
Fetal Blood
Osteoarthritis
Blood
47 Citations (Scopus)

Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA 448 circuit

Mak, K. K., Wu, A. T. H., Lee, W. H., Chang, T. C., Chiou, J. F., Wang, L. S., Wu, C. H., Huang, C. Y. F., Shieh, Y. S., Chao, T. Y., Ho, C. T., Yen, G. C. & Yeh, C-T., Jul 2013, In : Molecular Nutrition and Food Research. 57, 7, p. 1123-1134 12 p.

Research output: Contribution to journalArticle

Blueberry Plants
Tumor Microenvironment
Neoplastic Stem Cells
blueberries
MicroRNAs
3 Citations (Scopus)

Rapid and highly sensitive detection of Enterovirus 71 by using nanogold-enhanced electrochemical impedance spectroscopy

Li, H. Y., Tseng, S. H., Cheng, T. M., Chu, H. L., Lu, Y. N., Wang, F. Y., Tsai, L. Y., Shieh, J. Y., Yang, J. Y., Juan, C. C., Tu, L. C. & Chang, C. C., Jul 19 2013, In : Nanotechnology. 24, 28, 285102.

Research output: Contribution to journalArticle

Dielectric Spectroscopy
Enterovirus
Electrochemical impedance spectroscopy
Viruses
Electrodes
42 Citations (Scopus)

SENP1 deSUMOylates and regulates pin1 protein activity and cellular function

Chen, C. H., Chang, C. C., Lee, T. H., Luo, M., Huang, P., Liao, P. H., Wei, S., Li, F. A., Chen, R. H., Zhou, X. Z., Shih, H. M. & Lu, K. P., Jul 1 2013, In : Cancer Research. 73, 13, p. 3951-3962 12 p.

Research output: Contribution to journalArticle

Sumoylation
Peptidylprolyl Isomerase
Proteins
Small Ubiquitin-Related Modifier Proteins
Carcinogenesis
6 Citations (Scopus)

Synthesis of apolipoprotein B lipoparticles to deliver hydrophobic/ amphiphilic materials

Chu, H. L., Cheng, T. M., Chen, H. W., Chou, F. H., Chang, Y. C., Lin, H. Y., Liu, S. Y., Liang, Y. C., Hsu, M. H., Wu, D. S., Li, H. Y., Ho, L. P., Wu, P. C., Chen, F. R., Chen, G. S., Shieh, D. B., Chang, C. S., Su, C. H., Yao, Z. & Chang, C. C., Aug 14 2013, In : ACS Applied Materials and Interfaces. 5, 15, p. 7509-7516 8 p.

Research output: Contribution to journalArticle

Lipoproteins
Apolipoproteins B
Iron oxides
LDL Lipoproteins
Nanoparticles