The Ph.D. Program for Translational Medicine

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output 1995 2019

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Article
2017
11 Citations (Scopus)
Chemoradiotherapy
Thorax
Confidence Intervals
Therapeutics
Esophageal Squamous Cell Carcinoma
2016
8 Citations (Scopus)

Adipose-Derived Stem Cells Enhance Cancer Stem Cell Property and Tumor Formation Capacity in Lewis Lung Carcinoma Cells Through an Interleukin-6 Paracrine Circuit

Lu, J. H., Wei, H. J., Peng, B. Y., Chou, H. H., Chen, W. H., Liu, H. Y. & Deng, W. P., Dec 1 2016, In : Stem Cells and Development. 25, 23, p. 1833-1842 10 p.

Research output: Contribution to journalArticle

Lewis Lung Carcinoma
Neoplastic Stem Cells
Interleukin-6
Stem Cells
Neoplasms
4 Citations (Scopus)
Chinese Traditional Medicine
Prescriptions
Inappropriate Prescribing
Medication Errors
Clinical Decision Support Systems
27 Citations (Scopus)

Angiopoietin-like protein 1 antagonizes MET receptor activity to repress sorafenib resistance and cancer stemness in hepatocellular carcinoma

Chen, H-A., Kuo, T. C., Tseng, C. F., Ma, J. T., Yang, S. T., Yen, C. J., Yang, C. Y., Sung, S-Y. & Su, J. L., Nov 1 2016, In : Hepatology. 64, 5, p. 1637-1651 15 p.

Research output: Contribution to journalArticle

Angiopoietins
Hepatocellular Carcinoma
Gastropoda
Neoplasms
Proteins

Association between anxiety state and mitral valve disorders: A Taiwanese population-wide observational study

Dubey, N. K., Syed-Abdul, S., Nguyen, P. A., Dubey, R., Usman, I., Li, Y. C., Chen, W. H. & Deng, W. P., Aug 1 2016, In : Computer Methods and Programs in Biomedicine. 132, p. 57-61 5 p.

Research output: Contribution to journalArticle

Mitral Valve
Observational Studies
Anxiety
Health insurance
Pathology
9 Citations (Scopus)

Association of Sjögrens syndrome in patients with chronic hepatitis virus infection: A population-based analysis

Yeh, C. C., Wang, W. C., Wu, C. S., Sung, F. C., Su, C. T., Shieh, Y. H., Chang, S. N. & Su, F. H., Aug 1 2016, In : PLoS One. 11, 8, e0161958.

Research output: Contribution to journalArticle

chronic hepatitis
Hepatitis Viruses
Virus Diseases
Chronic Hepatitis
Hepatitis C virus
6 Citations (Scopus)

Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells

Wu, S. Y., Yan, M. D., Wu, A. T. H., Yuan, K. S. P. & Liu, S. H., 2016, In : Journal of Cancer. 7, 15, p. 2408-2419 12 p.

Research output: Contribution to journalArticle

Disintegrins
Seaweed
Metalloproteases
MicroRNAs
Phosphoric Monoester Hydrolases
14 Citations (Scopus)

Cancer-disease associations: A visualization and animation through medical big data

Usman, I., Hsu, C-K., Nguyen, P. A. A., Clinciu, D. L., Lu, R., Shabbir, S. A., Yang, H-C., Wang, Y-C., Huang, C-Y., Huang, C-W., Chang, Y-C., Hsu, M-H., Jian, W-S. & Li, Y-C. J., Apr 2016, In : Computer Methods and Programs in Biomedicine. 127, p. 44-51 8 p.

Research output: Contribution to journalArticle

Animation
Visualization
Neoplasms
Health insurance
Oncology
3 Citations (Scopus)
Radiation Tolerance
Methyltransferases
Down-Regulation
Breast Neoplasms
DNA
12 Citations (Scopus)

Chronic hepatitis infection is associated with extrahepatic cancer development: A nationwide population-based study in Taiwan

Kamiza, A. B., Su, F. H., Wang, W. C., Sung, F. C., Chang, S. N. & Yeh, C. C., Nov 8 2016, In : BMC Cancer. 16, 1, 861.

Research output: Contribution to journalArticle

Chronic Hepatitis
Taiwan
Confidence Intervals
Infection
Population
11 Citations (Scopus)

Cordyceps militaris treatment preserves renal function in type 2 diabetic nephropathy mice

Yu, S. H., Dubey, N. K., Li, W. S., Liu, M. C., Chiang, H. S., Leu, S. J., Shieh, Y. H., Tsai, F. C. & Deng, W. P., Nov 1 2016, In : PLoS One. 11, 11, e0166342.

Research output: Contribution to journalArticle

Cordyceps militaris
Cordyceps
diabetic nephropathy
Diabetic Nephropathies
renal function
3 Citations (Scopus)
suicide genes
Osteonectin
Gene therapy
Bone Neoplasms
gene therapy
11 Citations (Scopus)

Crosstalk between insulin-like growth factor (IGF) receptor and integrins through direct integrin binding to IGF1

Takada, Y., Takada, Y. K. & Fujita, M., Oct 26 2016, (Accepted/In press) In : Cytokine and Growth Factor Reviews.

Research output: Contribution to journalArticle

Somatomedin Receptors
Crosstalk
Integrins
Somatomedins
Extracellular Matrix
3 Citations (Scopus)
Clinical Decision Support Systems
Decision support systems
Randomized Controlled Trials
Physicians
Patient Safety
4 Citations (Scopus)

Early application of low-level laser may reduce the incidence of postherpetic neuralgia (PHN)

Chen, Y-T., Wang, H-H., Wang, T-J., Li, Y-C. & Chen, T-J., Sep 2016, In : Journal of the American Academy of Dermatology. 75, 3, p. 572-577 6 p.

Research output: Contribution to journalArticle

Postherpetic Neuralgia
Lasers
Incidence
Odds Ratio
Confidence Intervals
1 Citation (Scopus)

Effect of implementation of a coded problem list entry subsystem

Chen, C. C., Chang, C. H., Peng, Y. C., Poon, S. K., Huang, S. C. & Li, Y. C. J., Oct 1 2016, In : Computer Methods and Programs in Biomedicine. 134, p. 1-9 9 p.

Research output: Contribution to journalArticle

Electronic Health Records
Quality of Health Care
Motivation
Physicians
Electronic medical equipment
13 Citations (Scopus)

Erlotinib-Conjugated Iron Oxide Nanoparticles as a Smart Cancer-Targeted Theranostic Probe for MRI

Ali, A. A. A., Hsu, F. T., Hsieh, C. L., Shiau, C. Y., Chiang, C. H., Wei, Z. H., Chen, C. Y. & Huang, H. S., Nov 11 2016, In : Scientific Reports. 6, 36650.

Research output: Contribution to journalArticle

Nanoparticles
Neoplasms
Transmission Electron Microscopy
Heterografts
Nude Mice
11 Citations (Scopus)

Folate deficient tumor microenvironment promotes epithelial-to-mesenchymal transition and cancer stem-like phenotypes

Su, Y-H., Huang, W. C., Huang, H. T., Huang, Y. J., Sue, Y-K., Huynh, T. T., Hsiao, M., Liu, T. Z., Wu, TH. A. & Lin, C-M., May 31 2016, In : Oncotarget. 7, 22, p. 33246-33256 11 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Tumor Microenvironment
Folic Acid
Phenotype
Neoplasms
10 Citations (Scopus)
Platelet-Rich Plasma
Hyaluronic Acid
Chondrocytes
Adipocytes
Adipose Tissue
2 Citations (Scopus)

Genetic variation in the human sorbs1 gene is associated with blood pressure regulation and age at onset of hypertension: A SAPPHIRE cohort study

Chang, T. J., Wang, W. C., Hsiung, C. A., He, C. T., Lin, M. W., Sheu, W. H. H., Chang, Y. C., Quertermous, T., Chen, I., Rotter, J. & Chuang, L. M., Mar 4 2016, In : Medicine (United States). 95, 10, e2970.

Research output: Contribution to journalArticle

Age of Onset
Cohort Studies
Blood Pressure
Hypertension
Genes
4 Citations (Scopus)
AT-Hook Motifs
HSP90 Heat-Shock Proteins
Epithelial-Mesenchymal Transition
Hooks
colorectal neoplasms
Patient Readmission
International Classification of Diseases
Quality Improvement
Delivery of Health Care
3 Citations (Scopus)
Lactobacillus brevis
Solanum muricatum
Aminobutyrates
Solanum
anti-inflammatory activity
2 Citations (Scopus)

Klf10 deficiency in mice exacerbates pulmonary inflammation by increasing expression of the proinflammatory molecule NPRA

Huang, L. T., Chang, H. W., Wu, M. J., Lai, Y. T., Wu, W. C., Yu, W. C. Y. & Chang, V. H. S., Oct 1 2016, In : International Journal of Biochemistry and Cell Biology. 79, p. 231-238 8 p.

Research output: Contribution to journalArticle

Pneumonia
Genes
Transforming Growth Factors
Molecules
Pulmonary diseases
4 Citations (Scopus)

Ligand-induced epitope masking: Dissociation of integrin α5β1-fibronectin complexes only by monoclonal antibodies with an allosteric mode of action

Mould, A. P., Askari, J. A., Byron, A., Yoshikazu, T., Jowitt, T. A. & Humphries, M. J., Sep 30 2016, In : Journal of Biological Chemistry. 291, 40, p. 20993-21007 15 p.

Research output: Contribution to journalArticle

Fibronectins
Integrins
Epitopes
Monoclonal Antibodies
Ligands
19 Citations (Scopus)

Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women

Wang, Z., Seow, W. J., Shiraishi, K., Hsiung, C. A., Matsuo, K., Liu, J., Chen, K., Yamji, T., Yang, Y., Chang, I. S., Wu, C., Hong, Y. C., Burdett, L., Wyatt, K., Chung, C. C., Li, S. A., Yeager, M., Hutchinson, A., Hu, W., Caporaso, N. & 130 others, Landi, M. T., Chatterjee, N., Song, M., Fraumeni, J. F., Kohno, T., Yokota, J., Kunitoh, H., Ashikawa, K., Momozawa, Y., Daigo, Y., Mitsudomi, T., Yatabe, Y., Hida, T., Hu, Z., Dai, J., Ma, H., Jin, G., Song, B., Wang, Z., Cheng, S., Yin, Z., Li, X., Ren, Y., Guan, P., Chang, J., Tan, W., Chen, C. J., Chang, G. C., Tsai, Y. H., Su, W. C., Chen, K. Y., Huang, M. S., Chen, Y. M., Zheng, H., Li, H., Cui, P., Guo, H., Xu, P., Liu, L., Iwasaki, M., Shimazu, T., Tsugane, S., Zhu, J., Jiang, G., Fei, K., Park, J. Y., Kim, Y. H., Sung, J. S., Park, K. H., Kim, Y. T., Jung, Y. J., Kang, C. H., Park, I. K., Kim, H. N., Jeon, H. S., Choi, J. E., Choi, Y. Y., Kim, J. H., Oh, I. J., Kim, Y. C., Sung, S. W., Kim, J. S., Yoon, H. I., Kweon, S. S., Shin, M. H., Seow, A., Chen, Y., Lim, W. Y., Liu, J., Wong, M. P., Lee, V. H. F., Bassig, B. A., Tucker, M., Berndt, S. I., Chow, W. H., Ji, B. T., Wang, J., Xu, J., Sihoe, A. D. L., Ho, J. C. M., Chan, J. K. C., Wang, J. C., Lu, D., Zhao, X., Zhao, Z., Wu, J., Chen, H., Jin, L., Wei, F., Wu, G., An, S. J., Zhang, X. C., Su, J., Wu, Y. L., Gao, Y. T., Xiang, Y. B., He, X., Li, J., Zheng, W., Shu, X. O., Cai, Q., Klein, R., Pao, W., Lawrence, C., Hosgood, H. D., Hsiao, C. F., Chien, L. H., Chen, Y. H., Chen, C. H., Wang, W. C., Chen, C. Y., Wang, C. L., Yu, C. J., Chen, H. L., Su, Y. C., Tsai, F. Y., Chen, Y. S., Li, Y. J., Yang, T. Y., Lin, C. C., Yang, P. C., Wu, T., Lin, D., Zhou, B., Yu, J., Shen, H., Kubo, M., Chanock, S. J., Rothman, N. & Lan, Q., Feb 1 2016, In : Human Molecular Genetics. 25, 3, p. 620-629 10 p., ddv494.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Meta-Analysis
Lung Neoplasms
Smoking
Alleles
6 Citations (Scopus)
Areca
Radiation Tolerance
Mastication
MicroRNAs
Squamous Cell Carcinoma
17 Citations (Scopus)

MiR-520h is crucial for DAPK2 regulation and breast cancer progression

Su, C-M., Wang, M. Y., Hong, C., Chen, H-A., Su, Y. H., Wu, C-H., Huang, M-T., Chang, Y. W., Jiang, S. S., Sung, S-Y., Chang, J. Y., Chen, L. T., Chen, P. S. & Su, J. L., Mar 3 2016, In : Oncogene. 35, 9, p. 1134-1142 9 p.

Research output: Contribution to journalArticle

Death-Associated Protein Kinases
MicroRNAs
Breast Neoplasms
Drug Resistance
3' Untranslated Regions
4 Citations (Scopus)

Osteoporosis recovery by antrodia camphorata alcohol extracts through bone regeneration in SAMP8 Mice

Liu, H. Y., Huang, C. F., Li, C. H., Tsai, C. Y., Chen, W. H., Wei, H. J., Wang, M. F., Kuo, Y. H., Cheong, M. L. & Deng, W. P., 2016, In : Evidence-based Complementary and Alternative Medicine. 2016, 2617868.

Research output: Contribution to journalArticle

Antrodia
Bone Regeneration
Osteoporosis
Alcohols
Bone and Bones
12 Citations (Scopus)

Preclinical investigation of ibrutinib, a Bruton's kinase tyrosine (Btk) inhibitor, in suppressing glioma tumorigenesis and stem cell phenotypes

Wei, L., Su, Y. K., Lin, C. M., Chao, T. Y., Huang, S. P., Huynh, T. T., Jan, H. J., Whang-Peng, J., Chiou, J. F., Wu, A. T. H. & Hsiao, M., 2016, In : Oncotarget. 7, 43, p. 69961-69975 15 p.

Research output: Contribution to journalArticle

Glioma
Carcinogenesis
Stem Cells
Phenotype
Agammaglobulinaemia tyrosine kinase
12 Citations (Scopus)

Proton pump inhibitors and risk of periampullary cancers - A nested case-control study

Chien, L-N., Huang, Y. J., Shao, Y-H., Chang, C. J., Chuang, M. T., Chiou, H-Y. & Yen, Y., Mar 15 2016, In : International Journal of Cancer. 138, 6, p. 1401-1409 9 p.

Research output: Contribution to journalArticle

Proton Pump Inhibitors
Case-Control Studies
Neoplasms
Taiwan
Helicobacter pylori
21 Citations (Scopus)

REST reduction is essential for hypoxia-induced neuroendocrine differentiation of prostate cancer cells by activating autophagy signaling

Lin, T. P., Chang, Y. T., Lee, S. Y., Campbell, M., Wang, T. C., Shen, S. H., Chung, H. J., Chang, Y. H., Chiu, A. W., Pan, C. C., Lin, C. H., Chu, C. Y., Kung, H. J., Cheng, C. Y. & Chang, P. C., May 1 2016, In : Oncotarget. 7, 18, p. 26137-26151 15 p.

Research output: Contribution to journalArticle

Transcriptional Silencer Elements
Autophagy
Prostatic Neoplasms
Transcription Factors
AMP-Activated Protein Kinases
7 Citations (Scopus)

Risk factors for ectopic pregnancy in the Taiwanese population: A retrospective observational study

Hwang, A., Chou, L., Islam, M. M., Li, Y. C. & Syed-Abdul, S., Oct 1 2016, In : Archives of Gynecology and Obstetrics. 294, 4, p. 779-783 5 p.

Research output: Contribution to journalArticle

Ectopic Pregnancy
Observational Studies
Retrospective Studies
Population
Ovary
4 Citations (Scopus)
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Colonic Neoplasms
Chronic Obstructive Pulmonary Disease
Cohort Studies
Population
5 Citations (Scopus)

The effect of an integrated education model on anxiety and uncertainty in patients undergoing cervical disc herniation surgery

Chuang, M. F., Tung, H. H., Clinciu, D. L., Huang, J. S., Usman, I., Chang, C. J., Su, I. C., Lai, F. C. & Li, Y. C., Aug 1 2016, In : Computer Methods and Programs in Biomedicine. 133, p. 17-23 7 p.

Research output: Contribution to journalArticle

Surgery
Uncertainty
Anxiety
Education
Educational Models
4 Citations (Scopus)

TP53 polymorphisms and colorectal cancer risk in patients with lynch syndrome in Taiwan: A retrospective cohort study

Kamiza, A. B., Hsieh, L. L., Tang, R., Chien, H. T., Lai, C. H., Chiu, L. L., Lo, T. P., Hung, K. Y., You, J. F., Wang, W. C., Hsiung, C. A. & Yeh, C. C., Dec 1 2016, In : PLoS One. 11, 12, e0167354.

Research output: Contribution to journalArticle

Hereditary Nonpolyposis Colorectal Neoplasms
Polymorphism
colorectal neoplasms
cohort studies
Taiwan
7 Citations (Scopus)

Using structural-based protein engineering to modulate the differential inhibition effects of SAUGI on human and HSV uracil DNA glycosylase

Wang, H. C., Ho, C. H., Chou, C. C., Ko, T. P., Huang, M. F., Hsu, K. C. & Wang, A. H. J., May 19 2016, In : Nucleic Acids Research. 44, 9, p. 4440-4449 10 p.

Research output: Contribution to journalArticle

Uracil-DNA Glycosidase
Protein Engineering
Human Herpesvirus 4
DNA
Proteins
52 Citations (Scopus)

Xist reduction in breast cancer upregulates AKT phosphorylation via HDAC3-mediated repression of PHLPP1 expression

Huang, Y. S., Chang, C. C., Lee, S. S., Jou, Y. S. & Shih, H. M., 2016, In : Oncotarget. 7, 28, p. 43256-43266 11 p.

Research output: Contribution to journalArticle

Up-Regulation
Phosphorylation
Long Noncoding RNA
Breast Neoplasms
Cell Survival
2015
16 Citations (Scopus)

4-Acetylantroquinonol B inhibits colorectal cancer tumorigenesis and suppresses cancer stem-like phenotype

Chang, T. C., Yeh, C-T., Adebayo, B. O., Lin, Y-C., Deng, L., Rao, Y. K., Huang, C. C., Lee, W. H., Wu, A. T. H., Hsiao, M., Wu, C. H., Wang, L. S. & Tzeng, Y. M., Oct 15 2015, In : Toxicology and Applied Pharmacology. 288, 2, p. 258-268 11 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Carcinogenesis
oxaliplatin
Phenotype
Tumors
45 Citations (Scopus)

Activation of IL6/IGFIR confers poor prognosis of HBV-related hepatocellular carcinoma through induction of OCT4/NANOG expression

Chang, T. S., Wu, Y. C., Chi, C. C., Su, W. C., Chang, P. J., Lee, K. F., Tung, T. H., Wang, J., Liu, J-J., Tung, S. Y., Kuo, L. M., Ho, H. N., Ling, T. Y. & Huang, Y-H., Jan 1 2015, In : Clinical Cancer Research. 21, 1, p. 201-210 10 p.

Research output: Contribution to journalArticle

IGF Type 1 Receptor
Hepatitis B virus
Hepatocellular Carcinoma
Interleukin-6
RNA Interference
32 Citations (Scopus)

Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production

Wei, H. J., Zeng, R., Lu, J. H., Lai, W-F., Chen, W. H., Liu, H. Y., Chang, Y. T. & Deng, W. P., 2015, In : Oncotarget. 6, 10, p. 7713-7726 14 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Interleukin-6
Stem Cells
Growth
Neoplasms
4 Citations (Scopus)

A novel detection platform for shrimp white spot syndrome virus using an ICP11-dependent immunomagnetic reduction (IMR) assay

Liu, B. H., Lin, Y. C., Ho, C. S., Yang, C. C., Chang, Y. T., Chang, J. F., Li, C. Y., Cheng, C. S., Huang, J. Y., Lee, Y. F., Hsu, M. H., Lin, F. C., Wang, H. C., Lo, C. F., Yang, S. Y. & Wang, H. C., Sep 18 2015, In : PLoS One. 10, 9, e0138207.

Research output: Contribution to journalArticle

White spot syndrome virus 1
White spot syndrome virus
Viruses
Assays
shrimp
11 Citations (Scopus)

A novel tool for visualizing chronic kidney disease associated polymorbidity: a 13-year cohort study in Taiwan

Huang, C. W., Syed-Abdul, S., Jian, W. S., Iqbal, U., Nguyen, P. A. A. L., Lee, P., Lin, S. H., Hsu, W. D., Wu, M. S., Wang, C. F., Ma, K. L. & Li, Y. C. J. A., Mar 1 2015, In : Journal of the American Medical Informatics Association. 22, 2, p. 290-298 9 p.

Research output: Contribution to journalArticle

Taiwan
Chronic Renal Insufficiency
Cohort Studies
Comorbidity
National Health Programs
7 Citations (Scopus)
Electronic Health Records
Chronic Renal Insufficiency
Cohort Studies
Research Personnel
Administrative Personnel
3 Citations (Scopus)

Benign prostatic hyperplasia complicated with T1DM can be alleviated by treadmill exercise - evidences revealed by the rat model Voiding dysfunction

Chen, K. C., Sung, S. Y., Lin, Y. T., Hsieh, C. L., Shen, K. H., Peng, C. C. & Peng, R. Y., Nov 17 2015, In : BMC Urology. 15, 1, 104.

Research output: Contribution to journalArticle

Prostatic Hyperplasia
Type 1 Diabetes Mellitus
Androgen Receptors
Testosterone
Somatomedins
26 Citations (Scopus)
Berberine
Epithelial-Mesenchymal Transition
Prostatic Neoplasms
Genes
Neoplasm Metastasis
15 Citations (Scopus)

Bruton's tyrosine kinase (Btk) inhibitor ibrutinib suppresses stem-like traits in ovarian cancer

Zucha, M. A., Wu, A. T. H., Lee, W. H., Wang, L. S., Lin, W. W., Yuan, C. C. & Yeh, C-T., 2015, In : Oncotarget. 6, 15, p. 13255-13268 14 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Cisplatin
Neoplastic Stem Cells
Up-Regulation
Databases
23 Citations (Scopus)

Building a national electronic medical record exchange system - experiences in Taiwan

Li, Y. C. J., Yen, J. C., Chiu, W. T., Jian, W. S., Shabbir, S. A. & Hsu, M. H., Aug 1 2015, In : Computer Methods and Programs in Biomedicine. 121, 1, p. 14-20 7 p.

Research output: Contribution to journalArticle

Electronic medical equipment
Electronic Health Records
Taiwan
Health insurance
National Health Programs
2 Citations (Scopus)

CDK2 phosphorylation regulates the protein stability of KLF10 by interfering with binding of the E3 ligase SIAH1

Lin, C-H., Lin, S-Y., Chang, H-W., Ko, L-J., Tseng, Y-S., Chang, V. H. S. & Yu, W. C. Y., May 1 2015, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1853, 5, p. 1174-1181 8 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Protein Stability
Phosphorylation
Cell Cycle
Growth