The Ph.D. Program for Translational Medicine

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output 1995 2019

Filter
Article
2017
33 Citations (Scopus)

Benzodiazepine Use and Risk of Dementia in the Elderly Population: A Systematic Review and Meta-Analysis

Islam, M. M., Iqbal, U., Walther, B., Atique, S., Dubey, N. K., Nguyen, P. A., Poly, T. N., Masud, J. H. B., Li, Y. C. & Shabbir, S. A., 2017, In : Neuroepidemiology. p. 181-191 11 p.

Research output: Contribution to journalArticle

Benzodiazepines
Dementia
Meta-Analysis
Population
Observational Studies

BICD1 expression, as a potential biomarker for prognosis and predicting response to therapy in patients with glioblastomas

Huang, S. P., Chang, Y. C., Low, Q. H., Wu, A. T. H., Chen, C. L., Lin, Y. F. & Hsiao, M., Jan 1 2017, In : Oncotarget. 8, 69, p. 113766-113791 26 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Biomarkers
Atlases
Glioma
3 Citations (Scopus)

Characterization of a transgenic mouse model exhibiting spontaneous lung adenocarcinomas with a metastatic phenotype

Chang, H. W., Lin, Z. M., Wu, M. J., Wang, L. Y., Chow, Y. H., Jiang, S. S., Ch'ang, H. J. & Chang, V. H. S., Apr 1 2017, In : PLoS One. 12, 4, e0175586.

Research output: Contribution to journalArticle

adenocarcinoma
Transgenic Mice
lung neoplasms
animal models
lungs
6 Citations (Scopus)

CISD2 Haploinsufficiency Disrupts Calcium Homeostasis, Causes Nonalcoholic Fatty Liver Disease, and Promotes Hepatocellular Carcinoma

Shen, Z. Q., Chen, Y. F., Chen, J. R., Jou, Y. S., Wu, P. C., Kao, C. H., Wang, C. H., Huang, Y. L., Chen, C. F., Huang, T. S., Shyu, Y. C., Tsai, S. F., Kao, L. S. & Tsai, T. F., Nov 21 2017, In : Cell Reports. 21, 8, p. 2198-2211 14 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Liver
Hepatocellular Carcinoma
Homeostasis
Calcium
3 Citations (Scopus)

Combinatorial treatment with polyI: C and anti-IL6 enhances apoptosis and suppresses metastasis of lung cancer cells

Lau, W. H., Zhu, X. G., Ho, S. W. T., Chang, S. C. & Ding, J-L., 2017, In : Oncotarget. 8, 20, p. 32884-32904 21 p.

Research output: Contribution to journalArticle

Interleukin-6
Lung Neoplasms
Apoptosis
Neoplasm Metastasis
Cytokines
15 Citations (Scopus)
Transcriptome
Epigenomics
Gene expression
epigenetics
Liver
2 Citations (Scopus)

CRP-level-associated polymorphism rs1205 within the CRP gene is associated with 2-hour glucose level: The SAPPHIRe study

Sheu, W. H. H., Wang, W. C., Wu, K. D., He, C. T., Hwu, C. M., Quertermous, T., Hsieh, W. S., Lee, W. J., Ting, C. T., Chen, Y. D. I. & Hsiung, C. A., Dec 1 2017, In : Scientific Reports. 7, 1, p. 7987

Research output: Contribution to journalArticle

C-Reactive Protein
Insulin Resistance
Hypertension
Glucose
Genes

Cyproheptadine use in hepatocellular carcinoma

Hsieh, M. C., Lee, W. H., Wu, A. T. H., Chow, J. M., Chang, C. L., Yuan, K. S. P. & Wu, S. Y., 2017, In : American Journal of Cancer Research. 7, 3, p. 584-602 19 p.

Research output: Contribution to journalArticle

Cyproheptadine
Hepatocellular Carcinoma
Palliative Care
Cause of Death
Therapeutics
2 Citations (Scopus)

Direct binding to integrins and loss of disulfide linkage in IL-1β are involved in the agonistic action of IL-1β

Takada, Y. K., Yu, J., Fujita, M., Saegusa, J., Wu, C. Y. & Takada, Y., Jan 1 2017, In : Journal of Biological Chemistry. 292, 49, p. 20067-20075 9 p.

Research output: Contribution to journalArticle

Interleukin-1
Integrins
Disulfides
Interleukin-1 Receptors
Mutation
3 Citations (Scopus)

Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling

Prieto, D. M. C., Cheng, Y., Chang, C. C., Yu, J., Takada, Y. K. & Takada, Y., Sep 1 2017, In : PLoS One. 12, 9, e0184285.

Research output: Contribution to journalArticle

IGF Type 1 Receptor
integrins
somatomedins
Somatomedins
Integrins
5 Citations (Scopus)

Distinct roles and differential expression levels of Wnt5a mRNA isoforms in colorectal cancer cells

Huang, T. C., Lee, P. T., Wu, M. H., Huang, C. C., Ko, C. Y., Lee, Y. C., Lin, D. Y., Cheng, Y. W. & Lee, K. H., Aug 1 2017, In : PLoS One. 12, 8, e0181034.

Research output: Contribution to journalArticle

RNA Isoforms
colorectal neoplasms
Colorectal Neoplasms
Catenins
Cells
2 Citations (Scopus)

Does aspirin use reduce the risk for cancer?

Usman, I., Yang, H. C., Jian, W. S., Yen, Y. & Li, Y. C., Feb 1 2017, In : Journal of Investigative Medicine. 65, 2, p. 391-392 2 p.

Research output: Contribution to journalArticle

Aspirin
Digestive system
Digestive System
Neoplasms
International Classification of Diseases
16 Citations (Scopus)
Intensity-Modulated Radiotherapy
Chemoradiotherapy
Thorax
Mortality
Neoplasms
15 Citations (Scopus)
Esophagectomy
Chemoradiotherapy
Radiotherapy
Thorax
Confidence Intervals
Epidermal Growth Factor Receptor
Squamous Cell Carcinoma
Lung Neoplasms
Adenocarcinoma
Radiotherapy
2 Citations (Scopus)

Endothelial angiogenesis is directed by RUNX1T1-regulated VEGFA, BMP4 and TGF-β2 expression

Liao, K. H., Chang, S. J., Chang, H. C., Chien, C. L., Huang, T. S., Feng, T. C., Lin, W. W., Shih, C. C., Yang, M. H., Yang, S. H., Lin, C. H., Hwang, W. L. & Lee, O. K., Jun 1 2017, In : PLoS One. 12, 6, e0179758.

Research output: Contribution to journalArticle

Endothelial cells
angiogenesis
Ischemia
Endothelial Cells
ischemia
12 Citations (Scopus)

Exploring association between statin use and breast cancer risk: an updated meta-analysis

Islam, M. M., Yang, H. C., Nguyen, P. A., Poly, T. N., Huang, C. W., Kekade, S., Khalfan, A. M., Debnath, T., Li, Y. C. J. & Abdul, S. S., Sep 22 2017, (Accepted/In press) In : Archives of Gynecology and Obstetrics. p. 1-11 11 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Meta-Analysis
Breast Neoplasms
Odds Ratio
Observational Studies
4 Citations (Scopus)

Exploring the Association between Statin Use and the Risk of Parkinson's Disease: A Meta-Analysis of Observational Studies

Poly, T. N., Islam, M. M., Walther, B. A., Yang, H. C., Nguyen, P. A., Huang, C. W., Shabbir, S. A. & Li, Y. C. J., Dec 1 2017, In : Neuroepidemiology. 49, 3-4, p. 142-151 10 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Observational Studies
Parkinson Disease
Meta-Analysis
Simvastatin
4 Citations (Scopus)

Expression of a hepatitis B virus pre-S2 deletion mutant in the liver results in hepatomegaly and hepatocellular carcinoma in mice

Teng, Y. C., Neo, J. C., Wu, J. C., Chen, Y. F., Kao, C. H. & Tsai, T. F., Mar 1 2017, In : Journal of Pathology. 241, 4, p. 463-474 12 p.

Research output: Contribution to journalArticle

Hepatomegaly
Hepatitis B virus
Hepatocellular Carcinoma
Endoplasmic Reticulum
Liver
13 Citations (Scopus)

Feedback regulation of ALDOA activates the HIF-1α/MMP9 axis to promote lung cancer progression

Chang, Y. C., Chan, Y. C., Chang, W. M., Lin, Y. F., Yang, C. J., Su, C. Y., Huang, M. S., Wu, A. T. H. & Hsiao, M., Sep 10 2017, In : Cancer Letters. 403, p. 28-36 9 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Fructose-Bisphosphate Aldolase
Lung Neoplasms
Neoplasm Metastasis
Therapeutics
9 Citations (Scopus)
Neoplastic Stem Cells
Antioxidants
Side-Population Cells
Pancreatic Neoplasms
Tumors
1 Citation (Scopus)

Global Proteomics-based Identification and Validation of Thymosin Beta-4 X-Linked as a Prognostic Marker for Head and Neck Squamous Cell Carcinoma

Chi, L. H., Chang, W. M., Chang, Y. C., Chan, Y. C., Tai, C. C., Leung, K. W., Chen, C. L., Wu, A. T., Lai, T. C., Li, Y. C. & Hsiao, M., Dec 1 2017, In : Scientific Reports. 7, 1, 9031.

Research output: Contribution to journalArticle

Proteomics
Biomarkers
Neoplasm Metastasis
Carcinoma, squamous cell of head and neck
thymosin beta(4)
10 Citations (Scopus)

Glucose transporter 4 promotes head and neck squamous cell carcinoma metastasis through the TRIM24-DDX58 axis

Chang, Y. C., Chi, L. H., Chang, W. M., Su, C. Y., Lin, Y. F., Chen, C. L., Chen, M. H., Chang, P. M. H., Wu, A. T. H. & Hsiao, M., Jan 7 2017, In : Journal of Hematology and Oncology. 10, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Neoplasm Metastasis
Glycolysis
Glucose
Carcinoma, squamous cell of head and neck
6 Citations (Scopus)
Neuropilin-1
Galectin 1
Hepatic Stellate Cells
Platelet-Derived Growth Factor
Transforming Growth Factors

Granulysin expressed in a humanized mouse model induces apoptotic cell death and suppresses tumorigenicity

Hsiao, Y. W., Lai, T. C., Lin, Y. H., Su, C. Y., Lee, J. J., Liao, A. T., Lin, Y. F., Hsieh, S. C., Wu, A. T. H. & Hsiao, M., 2017, In : Oncotarget. 8, 48, p. 83495-83508 14 p.

Research output: Contribution to journalArticle

Cell Death
Immune System
Cytotoxic T-Lymphocytes
Natural Killer Cells
Blood Cells
14 Citations (Scopus)
Macrophages
Selenium
Fluorescence
Nanoparticles
Imaging techniques
3 Citations (Scopus)

Inhibition of chronic prostate inflammation by hyaluronic acid through an immortalized human prostate stromal cell line model

Liu, C. M., Chen, W. H., Chiou, C. S., Lo, W. C., Dubey, N. K., Chen, Y. C., Lai, W. F. T., Yeh, S. D., Chiang, H. S. & Deng, W. P., May 1 2017, In : PLoS One. 12, 5, e0178152.

Research output: Contribution to journalArticle

hyaluronic acid
stromal cells
Hyaluronic Acid
Stromal Cells
Prostatic Hyperplasia
5 Citations (Scopus)
Cholangiocarcinoma
Case-Control Studies
Diabetes Mellitus
Population
Cholecystectomy
4 Citations (Scopus)

KLF10 loss in the pancreas provokes activation of SDF-1 and induces distant metastases of pancreatic ductal adenocarcinoma in the Kras(G12D) p53(flox/flox) model

Weng, C-C., Hawse, J. R., Subramaniam, M., Chang, V. H. S., Yu, W. C. Y., Hung, W-C., Chen, L-T. & Cheng, K-H., Sep 28 2017, In : Oncogene. 36, 39, p. 5532-5543 12 p.

Research output: Contribution to journalArticle

Pancreas
Adenocarcinoma
Transcription Factors
Neoplasm Metastasis
Neoplasms
3 Citations (Scopus)

Krüpple-like factor 10 regulates radio-sensitivity of pancreatic cancer via UV radiation resistance-associated gene

Chang, V. H. S., Tsai, Y. C., Tsai, Y. L., Peng, S. L., Chen, S. L., Chang, T. M., Yu, W. C. Y. & Ch'ang, H. J., Mar 1 2017, In : Radiotherapy and Oncology. 122, 3, p. 476-484

Research output: Contribution to journalArticle

Radio
Pancreatic Neoplasms
Radiation
Genes
Autophagy
20 Citations (Scopus)
Survival
Incidence
Recurrence
Comorbidity
Chemoradiotherapy
37 Citations (Scopus)

Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression

Shih, J. W., Chiang, W. F., Wu, A. T. H., Wu, M. H., Wang, L. Y., Yu, Y. L., Hung, Y. W., Wang, W. C., Chu, C. Y., Hung, C. L., Changou, C. A., Yen, Y. & Kung, H. J., Jun 22 2017, In : Nature Communications. 8, 15874.

Research output: Contribution to journalArticle

Long Noncoding RNA
Mouth Neoplasms
progressions
hypoxia
cancer
6 Citations (Scopus)

Lymphotoxin-β Interacts with Methylated EGFR to Mediate Acquired Resistance to Cetuximab in Head and Neck Cancer

Hsu, D. S-S., Hwang, W-L., Yuh, C-H., Chu, C-H., Ho, Y-H., Chen, P-B., Lin, H-S., Lin, H-K., Wu, S-P., Lin, C-Y., Hsu, W-H., Lan, H-Y., Wang, H-J., Tai, S-K., Hung, M-C. & Yang, M-H., Feb 14 2017, In : Clinical Cancer Research.

Research output: Contribution to journalArticle

Lymphotoxin-alpha
Head and Neck Neoplasms
Mutation
Protein-Arginine N-Methyltransferases
Genes
4 Citations (Scopus)
Magnetic Resonance Spectroscopy
Radiotherapy
Neoplasm Metastasis
Bone and Bones
Therapeutic Uses
4 Citations (Scopus)

Non-invasive in vivo molecular imaging of intra-articularly transplanted immortalized bone marrow stem cells for osteoarthritis treatment

Peng, B., Chiou, C-S., Dubey, N. K., Yu, S. H., Deng, Y. H., Tsai, F. C., Chiang, H. S., Shieh, Y-H., Chen, W. H. & Deng, W-P., Sep 27 2017, In : Oncotarget. 8, 57, p. 97153-97164

Research output: Contribution to journalArticle

Molecular Imaging
Luciferases
Bone Marrow Cells
Osteoarthritis
Stem Cells
13 Citations (Scopus)

Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways

Huang, Y. J., Yang, C. K., Wei, P. L., Huynh, T. T., Whang-Peng, J., Meng, T. C., Hsiao, M., Tzeng, Y. M., Wu, A. T. & Yen, Y., Feb 28 2017, In : Journal of hematology & oncology. 10, 1, p. 60 1 p.

Research output: Contribution to journalArticle

Colon
Carcinogenesis
Colonic Neoplasms
Macrophages
Neoplasms
3 Citations (Scopus)

Reactive oxygen species-mediated switching expression of MMP-3 in stromal fibroblasts and cancer cells during prostate cancer progression

Hsieh, C. L., Liu, C. M., Chen, H. A., Yang, S. T., Shigemura, K., Kitagawa, K., Yamamichi, F., Fujisawa, M., Liu, Y. R., Lee, W. H., Chen, K. C., Shen, C. N., Lin, C. C., Chung, L. W. K. & Sung, S. Y., Dec 1 2017, In : Scientific Reports. 7, 1, 9065.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 3
Reactive Oxygen Species
Prostatic Neoplasms
Fibroblasts
Neoplasms
9 Citations (Scopus)

REST is a crucial regulator for acquiring EMT-like and stemness phenotypes in hormone-refractory prostate cancer

Chang, Y. T., Lin, T. P., Campbell, M., Pan, C. C., Lee, S. H., Lee, H. C., Yang, M. H., Kung, H. J. & Chang, P. C., Mar 3 2017, In : Scientific Reports. 7, 42795.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Prostatic Neoplasms
Hormones
Phenotype
Castration
1 Citation (Scopus)

rs2841277 (PLD4) is associated with susceptibility and rs4672495 is associated with disease activity in rheumatoid arthritis

Chen, W. C., Wang, W. C., Lu, H. F., Okada, Y., Chang, W. P., Chou, Y. H., Chang, H. H., Huang, J. D., Chen, D. Y. & Chang, W. C., 2017, In : Oncotarget. 8, 38, p. 64180-64190 11 p.

Research output: Contribution to journalArticle

Phospholipase D
Rheumatoid Arthritis
Ankylosing Spondylitis
Single Nucleotide Polymorphism
Genome-Wide Association Study
7 Citations (Scopus)

The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin αvβ3

Yu, J., Lee, C. Y., Changou, C. A., Cedano-Prieto, D. M., Takada, Y. K. & Takada, Y., Feb 15 2017, In : Biochemical Journal. 474, 4, p. 589-596 8 p.

Research output: Contribution to journalArticle

Integrins
Binding Sites
Tetraspanins
Ligands
Cell adhesion
4 Citations (Scopus)

The concomitant association of thyroid disorders and Myasthenia gravis

Lin, P. Y., Iqbal, U., Nguyen, P. A., Islam, M. M., Atique, S., Jian, W. S., Li, Y. C., Huang, C. L. & Hsu, C. H., Jan 1 2017, In : Translational Neuroscience. 8, 1, p. 27-30 4 p.

Research output: Contribution to journalArticle

Myasthenia Gravis
Thyroid Gland
Poisons
Nodular Goiter
Thyrotoxicosis
4 Citations (Scopus)
Neoplastic Stem Cells
trichostatin A
Colonic Neoplasms
Colon
Carcinogenesis

The impact of different surgical procedures on hypoparathyroidism after thyroidectomy

Chen, K. C., Iqbal, U., Nguyen, P. A., Hsu, C. H., Huang, C. L., Hsu, Y. H. E., Atique, S., Islam, M. M., Li, Y. C. J. & Jian, W. S., Oct 1 2017, In : Medicine. 96, 43, p. e8245

Research output: Contribution to journalArticle

Hypoparathyroidism
Thyroidectomy
Thyroid Gland
National Health Programs
Lymph Node Excision
4 Citations (Scopus)

The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis

Mori, S., Hatori, N., Kawaguchi, N., Hamada, Y., Shih, T. C., Wu, C. Y., Lam, K. S., Matsuura, N., Yamamoto, H., Takada, Y. K. & Takada, Y., Apr 30 2017, In : Bioscience Reports. 37, 2, BSR20170173.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Integrins
Glutamic Acid
Biological Phenomena
Fibroblast Growth Factors
2 Citations (Scopus)

The monomeric form of Neisseria DNA mimic protein DMP19 prevents DNA from binding to the histone-like HU protein

Huang, M. F., Lin, S. J., Ko, T. P., Liao, Y. T., Hsu, K. C. & Wang, H. C., Dec 1 2017, In : PLoS One. 12, 12, e0189461.

Research output: Contribution to journalArticle

Neisseria
histones
Histones
DNA
Dimers
3 Citations (Scopus)
Hemorrhoidectomy
Diltiazem
Ointments
Meta-Analysis
Randomized Controlled Trials

Two interrogated FBG spectral linewidth for strain sensing through correlation

Hsu, S. H., Chuang, K. W., Chen, C. S., Lin, C. Y. & Chang, C. C., Dec 7 2017, In : Sensors (Switzerland). 17, 12, 2837.

Research output: Contribution to journalArticle

Elastic Tissue
Fiber Bragg gratings
Linewidth
Bragg gratings
fibers
7 Citations (Scopus)

Uncovering exposures responsible for birth season - disease effects: a global study

Boland, M. R., Parhi, P., Li, L., Miotto, R., Carroll, R., Iqbal, U., Nguyen, P-A. A., Schuemie, M., You, S. C., Smith, D., Mooney, S., Ryan, P., Li, Y-C. J., Park, R. W., Denny, J., Dudley, J. T., Hripcsak, G., Gentine, P. & Tatonetti, N. P., Sep 28 2017, In : Journal of the American Medical Informatics Association : JAMIA.

Research output: Contribution to journalArticle

Parturition
First Pregnancy Trimester
Republic of Korea
Electronic Health Records
Sunlight
11 Citations (Scopus)
Chemoradiotherapy
Thorax
Confidence Intervals
Therapeutics
Esophageal Squamous Cell Carcinoma