The Ph.D. Program for Translational Medicine

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output 1992 2019

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Article
2018
3 Citations (Scopus)

Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) promotes EGF receptor signaling of oral squamous cell carcinoma metastasis via the complex N-glycosylation

Chiang, W. F., Cheng, T. M., Chang, C. C., Pan, S. H., Changou, C. A., Chang, T. H., Lee, K. H., Wu, S. Y., Chen, Y. F., Chuang, K. H., Shieh, D. B., Chen, Y. L., Tu, C. C., Tsui, W. L. & Wu, M. H., Jan 4 2018, In : Oncogene. 37, 1, p. 116-127 12 p.

Research output: Contribution to journalArticle

Carcinoembryonic Antigen
Cell Adhesion Molecules
Glycosylation
Epidermal Growth Factor Receptor
Squamous Cell Carcinoma

Combination of recurrent oral aphthae and dry eye syndrome may constitute an independent risk factor for oral cavity cancer in elderly women

Qin, L., Kao, Y. W., Lin, Y. L., Peng, B. Y., Deng, W. P., Chen, T. M., Lin, K. C., Yuan, K. S. P., Wu, A. T. H., Shia, B. C. & Wu, S. Y., Jan 1 2018, In : Cancer Management and Research. 10, p. 3273-3281 9 p.

Research output: Contribution to journalArticle

Dry Eye Syndromes
Aphthous Stomatitis
Mouth Neoplasms
Mouth
Taiwan
2 Citations (Scopus)

Correlation between diabetes mellitus and knee osteoarthritis: A dry-to-wet lab approach

Dubey, N. K., Ningrum, D. N. A., Dubey, R., Deng, Y-H., Li, Y-C., Wang, D. P., Wang, J. R., Syed-Abdul, S. & Deng, W-P., Jan 1 2018, In : International Journal of Molecular Sciences. 19, 10, 3021.

Research output: Contribution to journalArticle

diabetes mellitus
Knee Osteoarthritis
Medical problems
Diabetes Mellitus
obesity

Destruxin B suppresses drug-resistant colon tumorigenesis and stemness is associated with the upregulation of miR-214 and downregulation of mTOR/β-catenin pathway

Wu, S. Y., Huang, Y. J., Tzeng, Y. M., Huang, C. Y. F., Hsiao, M., Wu, A. T. H. & Huang, T. H., Oct 1 2018, In : Cancers. 10, 10, 353.

Research output: Contribution to journalArticle

Catenins
Sirolimus
Colonic Neoplasms
Colon
Carcinogenesis
Health Level Seven
Medical Informatics
Electronic Health Records
Interoperability
Information technology
9 Citations (Scopus)
docetaxel
Lecithins
Drug Delivery Systems
Therapeutics
Neoplasms
3 Citations (Scopus)
Catenins
Neoplastic Stem Cells
Diterpenes
Liver Neoplasms
Wnt Signaling Pathway
7 Citations (Scopus)

Dual inhibition of PIK3C3 and FGFR as a new therapeutic approach to treat bladder cancer

Chen, C. H., Changou, C. A., Hsieh, T. H., Lee, Y. C., Chu, C. Y., Hsu, K. C., Wang, H. C., Lin, Y. C., Lo, Y. N., Liu, Y. R., Liou, J. P. & Yen, Y., Mar 1 2018, In : Clinical Cancer Research. 24, 5, p. 1176-1189 14 p.

Research output: Contribution to journalArticle

Autophagy
Urinary Bladder Neoplasms
Cell Death
Therapeutics
Clustered Regularly Interspaced Short Palindromic Repeats

Effective Sirolimus Treatment for Refractory Spindle Cell Haemangioma

Ho, C. B., Hsieh, K., Chen, W. Y., Lin, Y. T., Chiou, J. F., Lee, H. L. & Shiah, H. S., May 11 2018, In : British Journal of Dermatology.

Research output: Contribution to journalArticle

Sirolimus
Hemangioma
Blood Vessels
Enchondromatosis
Therapeutics
2 Citations (Scopus)
Peritoneal Dialysis
renal function
dialysis
Cholesterol
cholesterol
1 Citation (Scopus)
Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Radiotherapy
Thorax
Therapeutics
1 Citation (Scopus)

EGFR, SMAD7, and TGFBR2 polymorphisms are associated with colorectal cancer in patients with lynch syndrome

Kamiza, A. B., Wang, W. C., You, J. F., Tang, R., Wang, Y. T., Chien, H. T., Lai, C. H., Chiu, L. L., Lo, T. P., Hung, K. Y., Hsiung, C. A. & Yeh, C. C., Oct 1 2018, In : Anticancer Research. 38, 10, p. 5983-5990 8 p.

Research output: Contribution to journalArticle

Hereditary Nonpolyposis Colorectal Neoplasms
Epidermal Growth Factor Receptor
Colorectal Neoplasms
Genotype
Transforming Growth Factors
9 Citations (Scopus)

Enhanced YAP expression leads to EGFR TKI resistance in lung adenocarcinomas

Lee, T. F., Tseng, Y. C., Nguyen, P. A., Li, Y. C., Ho, C. C. & Wu, C. W., Dec 1 2018, In : Scientific Reports. 8, 1, 271.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Proteins
Drug Resistance
Adenocarcinoma of lung
1 Citation (Scopus)

Gelatin–epigallocatechin gallate nanoparticles with hyaluronic acid decoration as eye drops can treat rabbit dry-eye syndrome effectively via inflammatory relief

Huang, H. Y., Wang, M. C., Chen, Z. Y., Chiu, W. Y., Chen, K. H., Lin, I-C., Yang, W-C., Wu, C. C. & Tseng, C-L., 2018, In : International Journal of Nanomedicine. 13, p. 7251-7273

Research output: Contribution to journalArticle

Dry Eye Syndromes
Hyaluronic acid
Ophthalmic Solutions
Hyaluronic Acid
Nanoparticles
2 Citations (Scopus)

Genetic variation of SORBS1 gene is associated with glucose homeostasis and age at onset of diabetes: A SAPPHIRe Cohort Study

Chang, T. J., Wang, W. C., Hsiung, C. A., He, C. T., Lin, M. W., Sheu, W. H. H., Chang, Y. C., Quertermous, T., Chen, Y. D. I., Rotter, J. I., Chuang, L. M., Hwu, C. M., Hung, Y. J., Lee, W. J. & Lee, I. T., Dec 1 2018, In : Scientific Reports. 8, 1, 10574.

Research output: Contribution to journalArticle

Age of Onset
Single Nucleotide Polymorphism
Homeostasis
Cohort Studies
Glucose
3 Citations (Scopus)

Gene-to-gene network analysis of the mediation of plant innate immunity by the eliciting plant response-like 1 (Epl1) elicitor of trichoderma formosa

Cheng, C. H., Shen, B. N., Shang, Q. W., Liu, L. Y. D., Peng, K. C., Chen, Y. H., Chen, F. F., Hu, S. F., Wang, Y. T., Wang, H. C., Wu, H. Y., Lo, C. T. & Lin, S. S., Jul 1 2018, In : Molecular Plant-Microbe Interactions. 31, 7, p. 683-691 9 p.

Research output: Contribution to journalArticle

Plant Immunity
Trichoderma
Gene Regulatory Networks
Taiwan
Innate Immunity
5 Citations (Scopus)

Gout drugs use and risk of cancer: A case-control study

Yang, H. C., Nguyen, P. A. A., Islam, M., Huang, C. W., Poly, T. N., Iqbal, U. & Li, Y. C. J., Jan 1 2018, (Accepted/In press) In : Joint Bone Spine.

Research output: Contribution to journalArticle

Gout
Case-Control Studies
Odds Ratio
Confidence Intervals
Pharmaceutical Preparations
2 Citations (Scopus)

Identification and preclinical evaluation of the small molecule, NSC745887, for treating glioblastomas via suppressing DcR3- associated signaling pathways

Fann, L. Y., Chen, Y., Chu, D. C., Weng, S. J., Chu, H. C., Wu, A. T. H., Lee, J. F., Ali, A. A. A., Chen, T. C., Huang, H. S. & Ma, K. H., Jan 1 2018, In : Oncotarget. 9, 15, p. 11922-11937 16 p.

Research output: Contribution to journalArticle

Glioblastoma
Brain Neoplasms
Caspase 3
Ataxia Telangiectasia Mutated Proteins
Staining and Labeling

IGF1 gene is associated with triglyceride levels in subjects with family history of hypertension from the SAPPHIRe and TWB projects

Wang, W. C., Chiu, Y. F., Chung, R. H., Hwu, C. M., Lee, I. T., Lee, C. H., Chang, Y. C., Hung, K. Y., Quertermous, T., Chen, Y. D. I. & Hsiung, C. A., Jun 14 2018, In : International Journal of Medical Sciences. 15, 10, p. 1035-1042 8 p.

Research output: Contribution to journalArticle

Somatomedins
Taiwan
Insulin Resistance
Triglycerides
Hypertension
7 Citations (Scopus)

Increased Risk of Dementia in Patients with Antidepressants: A Meta-Analysis of Observational Studies

Wang, Y. C., Tai, P. A., Poly, T. N., Islam, M. M., Yang, H. C., Wu, C. C. & Li, Y. C. J., Jan 1 2018, In : Behavioural Neurology. 2018, 1 p.

Research output: Contribution to journalArticle

Antidepressive Agents
Observational Studies
Dementia
Meta-Analysis
MEDLINE
1 Citation (Scopus)
Intensity-Modulated Radiotherapy
Propensity Score
Adenocarcinoma
Cohort Studies
Drug Therapy
2 Citations (Scopus)

Levothyroxine use and the risk of breast cancer: a nation-wide population-based case–control study

Wu, C. C., Yu, Y. Y., Yang, H. C., Nguyen, P. A., Poly, T. N., Islam, M. M., Iqbal, U., Khan, H. A. A., Wang, Y. C., Cheng, Y. T., Li, Y. C. & Jian, W. S., Aug 1 2018, In : Archives of Gynecology and Obstetrics. 298, 2, p. 389-396 8 p.

Research output: Contribution to journalArticle

Thyroxine
Confidence Intervals
Breast Neoplasms
Odds Ratio
Population
4 Citations (Scopus)

Mechanistic insight into hyaluronic acid and platelet-rich plasma-mediated anti-inflammatory and anti-apoptotic activities in osteoarthritic mice

Chiou, C. S., Wu, C. M., Dubey, N. K., Lo, W. C., Tsai, F. C., Xuan Tung, T. D., Hung, W. C., Hsu, W. C., Chen, W. H. & Deng, W. P., Dec 1 2018, In : Aging. 10, 12, p. 4152-4165 14 p.

Research output: Contribution to journalArticle

Platelet-Rich Plasma
Hyaluronic Acid
Anti-Inflammatory Agents
Chondrocytes
Interleukin-1
12 Citations (Scopus)

Mobile and wearable technologies in healthcare for the ageing population

Malwade, S., Abdul, S. S., Uddin, M., Nursetyo, A. A., Fernandez-Luque, L., Zhu, XK. K., Cilliers, L., Wong, C. P., Bamidis, P. & Li, Y. CJ., Jul 1 2018, In : Computer Methods and Programs in Biomedicine. 161, p. 233-237 5 p.

Research output: Contribution to journalArticle

Aging of materials
Technology
Delivery of Health Care
Medical Informatics
Health

Monitor, reduce and prevent the adverse outcomes for ensuring patient safety

Yang, H-C., Islam, M. D. M. & Li, Y-C. J., Jul 1 2018, In : International Journal for Quality in Health Care. 30, 6, p. 415 1 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

MRI tracking of polyethylene glycol-coated superparamagnetic iron oxide-labelled placenta-derived mesenchymal stem cells toward glioblastoma stem-like cells in a mouse model

Hsu, F. T., Wei, Z. H., Hsuan, Y. C. Y., Lin, W., Su, Y. C., Liao, C. H. & Hsieh, C. L., Jan 1 2018, (Accepted/In press) In : Artificial Cells, Nanomedicine and Biotechnology.

Research output: Contribution to journalArticle

Magnetic resonance
Glioblastoma
Stem cells
Mesenchymal Stromal Cells
Iron oxides
3 Citations (Scopus)

Nano-Diamino-Tetrac (NDAT) Enhances Resveratrol-Induced Antiproliferation by Action on the RRM2 Pathway in Colorectal Cancers

Nana, A. W., Wu, S. Y., Yang, Y. C. S., Chin, Y. T., Cheng, T. M., Ho, Y., Li, W. S., Liao, Y. M., Chen, Y. R., Shih, Y. J., Liu, Y. R., Pedersen, J., Incerpi, S., Hercbergs, A., Liu, L. F., Whang-Peng, J., Davis, P. J. & Lin, H. Y., Oct 1 2018, In : Hormones and Cancer. 9, 5, p. 349-360 12 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Oxidoreductases
Neoplasms
Integrins
Stilbenes
2 Citations (Scopus)

NSC 95397 suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and the ERK1/2 pathway

Dubey, N. K., Peng, B. Y., Lin, C. M., Wang, P. D., Wang, J. R., Chan, C. H., Wei, H. J. & Deng, W. P., Jun 1 2018, In : International Journal of Molecular Sciences. 19, 6, 1625.

Research output: Contribution to journalArticle

2,3-bis(2-hydroxyethylsulfanyl)-(1,4)naphthoquinone
Mitogen-Activated Protein Kinase Phosphatases
Dual Specificity Phosphatase 1
phosphatases
MAP Kinase Signaling System
2 Citations (Scopus)

Polymorphisms of DNA repair genes are associated with colorectal cancer in patients with Lynch syndrome

Kamiza, A. B., Hsieh, L. L., Tang, R., Chien, H. T., Lai, C. H., Chiu, L. L., Lo, T. P., Hung, K. Y., You, J. F., Wang, W. C., Hsiung, C. A. & Yeh, C. C., Jul 1 2018, In : Molecular Genetics and Genomic Medicine. 6, 4, p. 533-540 8 p.

Research output: Contribution to journalArticle

Hereditary Nonpolyposis Colorectal Neoplasms
DNA Repair
Colorectal Neoplasms
Confidence Intervals
Genes
1 Citation (Scopus)

Polymorphisms of xenobiotic-metabolizing genes and colorectal cancer risk in patients with lynch syndrome: A retrospective cohort study in Taiwan

Kamiza, A. B., You, J. F., Wang, W. C., Tang, R., Chang, C. Y., Chien, H. T., Lai, C. H., Chiu, L. L., Lo, T. P., Hung, K. Y., Hsiung, C. A. & Yeh, C. C., 2018, In : Environmental and Molecular Mutagenesis.

Research output: Contribution to journalArticle

Hereditary Nonpolyposis Colorectal Neoplasms
Xenobiotics
Taiwan
Colorectal Neoplasms
Cohort Studies
1 Citation (Scopus)

Predicting 90-day mortality in locoregionally advanced head and neck squamous cell carcinoma after curative surgery

Qin, L., Chen, T. M., Kao, Y. W., Lin, K. C., Yuan, K. S. P., Wu, A. T. H., Shia, B. C. & Wu, S. Y., Oct 22 2018, In : Cancers. 10, 10, 392.

Research output: Contribution to journalArticle

Mortality
Comorbidity
Survival Rate
Carcinoma, squamous cell of head and neck
Neck Dissection
8 Citations (Scopus)

Quantitative Analysis of Glucose Metabolic Cleavage in Glucose Transporters Overexpressed Cancer Cells by Target-Specific Fluorescent Gold Nanoclusters

Cheng, T. M., Chu, H. L., Lee, Y. C., Wang, D. Y., Chang, C. C., Chung, K. L., Yen, H. C., Hsiao, C. W., Pan, X. Y., Kuo, T. R. & Chen, C. C., Mar 20 2018, In : Analytical Chemistry. 90, 6, p. 3974-3980 7 p.

Research output: Contribution to journalArticle

Facilitative Glucose Transport Proteins
Nanoclusters
Gold
Cells
Glucose

Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers: A case-control frequency-matched study

Qin, L., Kao, Y. W., Lin, Y. L., Peng, B. Y., Deng, W. P., Chen, T. M., Lin, K. C., Yuan, K. S. P., Wu, A. T. H., Shia, B. C. & Wu, S. Y., Jan 1 2018, (Accepted/In press) In : Cancer Medicine.

Research output: Contribution to journalArticle

Case-Control Studies
Confidence Intervals
Neoplasms
Sutton disease 2
Databases
7 Citations (Scopus)

Resveratrol induces sumoylated COX-2-dependent anti-proliferation in human prostate cancer LNCaP cells

Cheng, T. M., Chin, Y. T., Ho, Y., Chen, Y. R., Yang, Y. N., Yang, Y. C., Shih, Y. J., Lin, T. I., Lin, H. Y. & Davis, P. J., Feb 1 2018, In : Food and Chemical Toxicology. 112, p. 67-75 9 p.

Research output: Contribution to journalArticle

resveratrol
prostatic neoplasms
prostaglandin synthase
Cyclooxygenase 2
Prostatic Neoplasms
3 Citations (Scopus)

Risk analysis of malignant potential of oral verrucous hyperplasia: A follow-up study of 269 patients and copy number variation analysis

Wu, M. H., Luo, J. D., Wang, W. C., Chang, T. H., Hwang, W. L., Lee, K. H., Liu, S. Y., Yang, J. W., Chiou, C. T., Chang, C. H. & Chiang, W. F., Jan 1 2018, (Accepted/In press) In : Head and Neck.

Research output: Contribution to journalArticle

Hyperplasia
Oral Submucous Fibrosis
Mastication
Survival Rate
Gene Amplification

Risk of Hemorrhagic Stroke in Patients Exposed to Nonsteroidal Anti-Inflammatory Drugs: A Meta-Analysis of Observational Studies

Islam, M. M., Poly, T. N., Walther, B. A., Yang, H. C., Lin, M. C. & Li, Y. C., Jan 1 2018, (Accepted/In press) In : Neuroepidemiology. p. 166-176 11 p.

Research output: Contribution to journalArticle

Observational Studies
Meta-Analysis
Anti-Inflammatory Agents
Stroke
Odds Ratio
5 Citations (Scopus)

Seroprevalence of hepatitis B virus in Taiwan 30 years after the commencement of the national vaccination program

Hu, Y. C., Yeh, C. C., Chen, R. Y., Su, C. T., Wang, W. C., Bai, C. H., Chan, C. F. & Su, F. H., Jan 1 2018, In : PeerJ. 2018, 2, e4297.

Research output: Contribution to journalArticle

Hepatitis B virus
Seroepidemiologic Studies
Taiwan
Viruses
seroprevalence
1 Citation (Scopus)

Serum ApoA4 levels predicted the progression of renal impairment in T2DM

Cheng, C-W., Chang, C-C., Chen, H-W., Lin, C-Y. & Chen, J-S., Apr 19 2018, In : European Journal of Clinical Investigation. p. e12937

Research output: Contribution to journalArticle

Medical problems
Diabetic Nephropathies
Diabetes Mellitus
Kidney
Serum
4 Citations (Scopus)

Sex hormone-binding globulin (SHBG) is a potential early diagnostic biomarker for gastric cancer

Cheng, C. W., Chang, C. C., Patria, Y. N., Chang, R. T., Liu, Y. R., Li, F. A., Shih, H. M. & Lin, C. Y., Jan 1 2018, In : Cancer Medicine. 7, 1, p. 64-74 11 p.

Research output: Contribution to journalArticle

Sex Hormone-Binding Globulin
Stomach Neoplasms
Biomarkers
Blood Proteins
Western Blotting
Acupressure
Stem Cell Factor
Blood Cells
Drug Therapy
Hemoglobins
4 Citations (Scopus)

Skeletal muscle in aged mice reveals extensive transformation of muscle gene expression

Lin, I. H., Chang, J. L., Hua, K., Huang, W. C., Hsu, M. T. & Chen, Y. F., Aug 8 2018, In : BMC Genetics. 19, 1, 55.

Research output: Contribution to journalArticle

Skeletal Muscle
Gene Expression
Muscles
Sarcopenia
Quadriceps Muscle

SUMOylation of XRCC1 activated by poly (ADP-ribosyl)ation regulates DNA repair

Hu, L. Y., Chang, C. C., Huang, Y. S., Chou, W. C., Lin, Y. M., Ho, C. C., Chen, W. T., Shih, H. M., Hsiung, C. N., Wu, P. E. & Shen, C. Y., Jul 1 2018, In : Human Molecular Genetics. 27, 13, p. 2306-2317 12 p.

Research output: Contribution to journalArticle

Sumoylation
DNA Repair
Adenosine Diphosphate
Methyl Methanesulfonate
DNA Damage
4 Citations (Scopus)

The association between BDNF Val66Met polymorphism and emotional symptoms after mild traumatic brain injury

Wang, Y. J., Chen, K. Y., Kuo, L. N., Wang, W. C., Hsu, Y. W., Wong, H. S. C., Lin, C. M., Liao, K. H., Zhang, Y. F., Chiang, Y. H. & Chang, W. C., Jan 22 2018, In : BMC Medical Genetics. 19, 1, 13.

Research output: Contribution to journalArticle

Brain Concussion
Brain-Derived Neurotrophic Factor
Equipment and Supplies
Alleles
Depression

Therapeutic effect of repurposed temsirolimus in lung adenocarcinoma model

Chang, H. W., Wu, M. J., Lin, Z. M., Wang, C. Y., Cheng, S. Y., Lin, Y. K., Chow, Y. H., Ch'ang, H. J. & Chang, V. H. S., Jul 24 2018, In : Frontiers in Pharmacology. 9, JUL, p. 778 778.

Research output: Contribution to journalArticle

Therapeutic Uses
gemcitabine
Cisplatin
Lung Neoplasms
Neoplasms
2 Citations (Scopus)

The role of sentrin-specific protease 2 substrate recognition in TGF-β-induced tumorigenesis

Chang, C. C., Huang, Y. S., Lin, Y. M., Lin, C. J., Jeng, J. C., Liu, S. M., Ho, T. L., Chang, R. T., Changou, C. A., Ho, C. C. & Shih, H. M., Dec 1 2018, In : Scientific Reports. 8, 1, 9786.

Research output: Contribution to journalArticle

SUMO-1 Protein
Transforming Growth Factors
Carcinogenesis
Peptide Hydrolases
Cell Movement
9 Citations (Scopus)

The usefulness and actual use of wearable devices among the elderly population

Kekade, S., Hseieh, C. H., Islam, M. M., Atique, S., Mohammed Khalfan, A., Li, Y. C. & Abdul, S. S., Jan 1 2018, In : Computer Methods and Programs in Biomedicine. 153, p. 137-159 23 p.

Research output: Contribution to journalArticle

Equipment and Supplies
Population
Health
Monitoring
Technology
3 Citations (Scopus)

Transcriptome analysis and prognosis of ALDH isoforms in human cancer

Chang, P. M. H., Chen, C. H., Yeh, C. C., Lu, H. J., Liu, T. T., Chen, M. H., Liu, C. Y., Wu, A. T. H., Yang, M. H., Tai, S. K., Mochly-Rosen, D. & Huang, C. Y. F., Feb 9 2018, In : Scientific Reports. 8, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Gene Expression Profiling
Protein Isoforms
Neoplasms
RNA Sequence Analysis
Atlases
3 Citations (Scopus)

Tumor-targeted immunotherapy by using primary adipose-derived stem cells and an antigen-specific protein vaccine

Lu, J. H., Peng, B. Y., Chang, C. C., Dubey, N. K., Lo, W. C., Cheng, H. C., Wang, J. R., Wei, H. J. & Deng, W. P., Nov 15 2018, In : Cancers. 10, 11, 446.

Research output: Contribution to journalArticle

Immunotherapy
Stem Cells
Vaccines
Antigens
Neoplasms
1 Citation (Scopus)

Using modified information delivery to enhance the traditional pharmacy OSCE program at TMU – a pilot study

Lin, C. W., Chang, E. H., Clinciu, D. L., Peng, Y. T., Huang, W. C., Wu, C. C., Wu, J. C. & Li, Y. C., May 1 2018, In : Computer Methods and Programs in Biomedicine. 158, p. 147-152 6 p.

Research output: Contribution to journalArticle

Students
Education
Aptitude
Prescriptions
Curricula