The Ph.D. Program for Neural Regenerative Medicine

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    11031 Taipei

Research Output 2000 2019

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2019

Altered frontal aslant tracts as a heritable neural basis of social communication deficits in autism spectrum disorder: A sibling study using tract-based automatic analysis

Lo, Y. C., Chen, Y. J., Hsu, Y. C., Chien, Y. L., Gau, S. S. F. & Tseng, W. Y. I., 2019, In : Autism Research.

Research output: Contribution to journalArticle

Siblings
Anisotropy
Communication
Phenotype
Diffusion Magnetic Resonance Imaging
Open Access
Acid Sensing Ion Channels
Brain Concussion
Dizziness
Alleles
Genes

BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine

Chao, P. K., Chang, H. F., Chang, W. T., Yeh, T. K., Ou, L. C., Chuang, J. Y., Tsu-An Hsu, J., Tao, P. L., Loh, H. H., Shih, C., Ueng, S. H. & Yeh, S. H., Jan 1 2019, In : Neuropharmacology. 107678.

Research output: Contribution to journalArticle

Peptide Receptors
mu Opioid Receptor
Morphine
Naloxone
Arrestin

Cerebro-Cerebellar Pathways for Verbal Working Memory

Sobczak-Edmans, M., Lo, Y-C., Hsu, Y-C., Chen, Y-J., Kwok, F. Y., Chuang, K-H., Tseng, W-Y. I. & Chen, S. H. A., 2019, In : Frontiers in Human Neuroscience. 12, p. 530

Research output: Contribution to journalArticle

Short-Term Memory
Cerebellum
Parietal Lobe
Pons
Prefrontal Cortex

Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice

Chao, P. K., Chang, H. F., Ou, L. C., Chuang, J. Y., Lee, P. T., Chang, W. T., Chen, S. C., Ueng, S. H., Hsu, J. T. A., Tao, P. L., Law, P. Y., Loh, H. H. & Yeh, S. H., Dec 1 2019, In : Scientific Reports. 9, 1, 2405.

Research output: Contribution to journalArticle

mu Opioid Receptor
Endocytosis
Morphine
Ligands
Morphine Dependence
temozolomide
Dehydroepiandrosterone
Glioblastoma
Acetylation
Phosphorylation
Neuronal Plasticity
Electric Impedance
Brain
Motor Evoked Potentials
Transcranial Magnetic Stimulation
Embryonal Carcinoma Stem Cells
Neural Stem Cells
Zinc Fingers
Transcription
Zinc
Open Access
homing
brain damage
stem cells
fibroblasts
Fibroblasts

Gene-Embedded Nanostructural Biotic-Abiotic Optoelectrode Arrays Applied for Synchronous Brain Optogenetics and Neural Signal Recording

Huang, W. C., Chi, H. S., Lee, Y. C., Lo, Y. C., Liu, T. C., Chiang, M. Y., Chen, H. Y., Li, S. J., Chen, Y. Y. & Chen, S. Y., Mar 27 2019, In : ACS Applied Materials and Interfaces. 11, 12, p. 11270-11282 13 p.

Research output: Contribution to journalArticle

Brain
Genes
Polyethyleneimine
Neurotensin
Plasmids
Open Access
Cell Cycle Proteins
Epithelial-Mesenchymal Transition
regulators
Prostatic Neoplasms
genes

Ketamine ameliorates severe traumatic event-induced antidepressant-resistant depression in a rat model through ERK activation

Lee, C. W., Chen, Y. J., Wu, H. F., Chung, Y. J., Lee, Y. C., Li, C. T. & Lin, H. C., Jul 13 2019, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 93, p. 102-113 12 p.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
Ketamine
Antidepressive Agents
Serotonin Uptake Inhibitors
Depression
1 Citation (Scopus)

Leukemia Inhibitory Factor Promotes Castration-resistant Prostate Cancer and Neuroendocrine Differentiation by Activated ZBTB46

Liu, Y-N., Niu, S., Chen, W-Y., Zhang, Q., Tao, Y., Chen, W-H., Jiang, K-C., Chen, X., Shi, H., Liu, A., Li, J., Li, Y., Lee, Y-C., Zhang, X. & Huang, J., Apr 8 2019, In : Clinical cancer research : an official journal of the American Association for Cancer Research.

Research output: Contribution to journalArticle

Leukemia Inhibitory Factor
Castration
Prostatic Neoplasms
Androgens
Therapeutics

Morphological control of mitochondria as the novel mechanism of Gastrodia elata in attenuating mutant huntingtin-induced protein aggregations

Huang, N. K., Lin, C. C., Lin, Y. L., Huang, C. L., Chiou, C. T., Lee, Y. C., Lee, S. Y., Huang, H. T. & Yang, Y. C., Jun 1 2019, In : Phytomedicine. 59, 152756.

Research output: Contribution to journalArticle

Gastrodia
Mutant Proteins
Huntington Disease
Mitochondria
Mitochondrial Dynamics

MR imaging central thalamic deep brain stimulation restored autistic-like social deficits in the rat

Lin, T. C., Lo, Y. C., Lin, H. C., Li, S. J., Lin, S. H., Wu, H. F., Chu, M. C., Lee, C. W., Lin, I. C., Chang, C. W., Liu, Y. C., Chen, T. C., Lin, Y. J., Ian Shih, Y. Y. & Chen, Y. Y., Jan 1 2019, In : Brain Stimulation.

Research output: Contribution to journalArticle

Deep Brain Stimulation
Thalamic Nuclei
Magnetic Resonance Imaging
Interpersonal Relations
Brain
Coumarins
Cell death
Colonic Neoplasms
Cell Death
Cells

Pomalidomide Reduces Ischemic Brain Injury in Rodents

Tsai, Y. R., Tweedie, D., Navas-Enamorado, I., Scerba, M. T., Chang, C. F., Lai, J. H., Wu, J. C. C., Chen, Y. H., Kang, S. J., Hoffer, B. J., de Cabo, R., Greig, N. H., Chiang, Y. H. & Chen, K. Y., Apr 1 2019, In : Cell Transplantation. 28, 4, p. 439-450 12 p.

Research output: Contribution to journalArticle

Open Access
Brain Injuries
Rodentia
Brain
Rats
Surface active agents

Potential therapeutic effect of curcumin, a natural mTOR inhibitor, in tuberous sclerosis complex

Kuo, C. J., Huang, C. C., Chou, S. Y., Lo, Y. C., Kao, T. J., Huang, N. K., Lin, C., Lin, H. C., Lin, H. C. & Lee, Y. C., Feb 15 2019, In : Phytomedicine. 54, p. 132-139 8 p.

Research output: Contribution to journalArticle

Tuberous Sclerosis
Curcumin
Therapeutic Uses
Memory Disorders
Lipids

Prevalence and clinical characteristics of stroke patients with p.R544C NOTCH3 mutation in Taiwan

Tang, S. C., Chen, Y. R., Chi, N. F., Chen, C. H., Cheng, Y. W., Hsieh, F. I., Hsieh, Y. C., Yeh, H. L., Sung, P. S., Hu, C. J., Chern, C. M., Lin, H. J., Lien, L. M., Peng, G. S., Chiou, H. Y. & Jeng, J. S., Jan 1 2019, In : Annals of Clinical and Translational Neurology. 6, 1, p. 121-128 8 p.

Research output: Contribution to journalArticle

Taiwan
Stroke
Mutation
Cerebral Hemorrhage
CADASIL

Promyelocytic leukemia zinc finger is involved in the formation of deep layer cortical neurons

Lin, H. C., Ching, Y. H., Huang, C. C., Pao, P. C., Lee, Y. H., Chang, W. C., Kao, T. J. & Lee, Y. C., Apr 26 2019, In : Journal of Biomedical Science. 26, 1, 30.

Research output: Contribution to journalArticle

Open Access
Zinc Fingers
Neurons
Zinc
Leukemia
Brain

Psychometric Evaluation of Anxiety, Depression, and Sleep Quality after a Mild Traumatic Brain Injury: A Longitudinal Study

Ma, H-P., Chen, P-S., Wong, C-S., Chang, C-F., Ou, J-C., Tsai, Y-R., Chiu, W-T., Tsai, S-H., Liao, K-H., Chiang, Y-H., Wang, J-Y., Chen, K-Y. & Wu, J. C-C., 2019, In : Behavioural Neurology. 2019, p. 4364592

Research output: Contribution to journalArticle

Brain Concussion
Psychometrics
Longitudinal Studies
Sleep
Anxiety

Sp1 in Astrocyte Is Important for Neurite Outgrowth and Synaptogenesis

Hung, C. Y., Hsu, T. I., Chuang, J. Y., Su, T. P., Chang, W. C. & Hung, J. J., Jan 1 2019, In : Molecular Neurobiology.

Research output: Contribution to journalArticle

Astrocytes
Synapses
Hippocampus
Neurons
Toll-Like Receptor 2
2018
3 Citations (Scopus)
Activating Transcription Factors
CC Chemokines
Epithelial-Mesenchymal Transition
Androgens
Prostatic Neoplasms

A novel missense mutation of the GTP cyclohydrolase 1 gene in a Taiwanese family with dopa-responsive dystonia: A case report

Yang, C. C., Wang, W. C., Yeh, T. H., Chen, T. H., Liu, Y. L., Lu, M. K., Lu, C. S. & Tsai, C. H., Feb 1 2018, In : Clinical Neurology and Neurosurgery. 165, p. 21-23 3 p.

Research output: Contribution to journalArticle

GTP Cyclohydrolase
Missense Mutation
Dystonia
Genes
Leg
4 Citations (Scopus)

Astrocytic CCAAT/Enhancer-binding protein delta contributes to reactive oxygen species formation in neuroinflammation

Wang, S. M., Lim, S. W., Wang, Y. H., Lin, H. Y., Lai, M. D., Ko, C. Y. & Wang, J. M., Jun 1 2018, In : Redox Biology. 16, p. 104-112 9 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Protein-delta
Oxidative stress
Reactive Oxygen Species
Astrocytes
Oxidative Stress
2 Citations (Scopus)

C9orf72 is essential for neurodevelopment and motility mediated by Cyclin G1

Yeh, T. H., Liu, H. F., Li, Y. W., Lu, C. S., Shih, H. Y., Chiu, C. C., Lin, S. J., Huang, Y. C. & Cheng, Y. C., Jun 1 2018, In : Experimental Neurology. 304, p. 114-124 11 p.

Research output: Contribution to journalArticle

Cyclin G1
Embryonic Structures
GTP Phosphohydrolases
Zebrafish
Apoptosis
8 Citations (Scopus)

Caveolin-1 Controls Hyperresponsiveness to Mechanical Stimuli and Fibrogenesis-Associated RUNX2 Activation in Keloid Fibroblasts

Hsu, C. K., Lin, H. H., Harn, H. I., Ogawa, R., Wang, Y. K., Ho, Y. T., Chen, W. R., Lee, Y. C., Lee, J. Y. Y., Shieh, S. J., Cheng, C. M., McGrath, J. A. & Tang, M. J., Jan 1 2018, In : Journal of Investigative Dermatology. 138, 1, p. 208-218 11 p.

Research output: Contribution to journalArticle

Caveolin 1
Keloid
Fibroblasts
Chemical activation
trichostatin A
3 Citations (Scopus)

Cerebral Motor Functional Connectivity at the Acute Stage: An Outcome Predictor of Ischemic Stroke

Chi, N. F., Ku, H. L., Chen, D. Y. T., Tseng, Y. C., Chen, C. J., Lin, Y. C., Hsieh, Y. C., Chan, L., Chiou, H. Y., Hsu, C. Y. & Hu, C. J., Dec 1 2018, In : Scientific Reports. 8, 1, 16803.

Research output: Contribution to journalArticle

Stroke
Motor Cortex
Multivariate Analysis
Odds Ratio
Magnetic Resonance Imaging

Chronic pulmonary exposure to traffic-related fine particulate matter causes brain impairment in adult rats

Shih, C. H., Chen, J. K., Kuo, L. W., Cho, K. H., Hsiao, T. C., Lin, Z. W., Lin, Y. S., Kang, J. H., Lo, Y. C., Chuang, K. J., Cheng, T. J. & Chuang, H. C., Nov 9 2018, In : Particle and Fibre Toxicology. 15, 1, 1 p.

Research output: Contribution to journalArticle

Particulate Matter
Rats
Brain
Hippocampus
Air Pollution
1 Citation (Scopus)
Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Prostatic Neoplasms
Genes
Castration
6 Citations (Scopus)
Atrial Fibrillation
Safety
Hemorrhage
Myocardial Infarction
Rivaroxaban
1 Citation (Scopus)

Effect of traumatic brain injury on nicotine-induced modulation of dopamine release in the striatum and nucleus accumbens shell

Chen, Y. H., Kuo, T. T., Huang, E. Y. K., Chou, Y. C., Chiang, Y. H., Hoffer, B. J. & Miller, J., Jan 1 2018, In : Oncotarget. 9, 11, p. 10016-10028 13 p.

Research output: Contribution to journalArticle

Nucleus Accumbens
Nicotine
Dopamine
Percussion
Reward

Glucose-dependent insulinotropic polypeptide mitigates 6-OHDA-induced behavioral impairments in Parkinsonian rats

Yu, Y. W., Hsueh, S. C., Lai, J. H., Chen, Y. H., Kang, S. J., Chen, K. Y., Hsieh, T. H., Hoffer, B. J., Li, Y., Greig, N. H. & Chiang, Y. H., Apr 11 2018, In : International Journal of Molecular Sciences. 19, 4, 1153.

Research output: Contribution to journalArticle

Oxidopamine
Polypeptides
polypeptides
impairment
glucose
1 Citation (Scopus)
Open Access
Oxidative Stress
Acetaminophen
Liver
Wounds and Injuries
Hep G2 Cells
1 Citation (Scopus)

Highly sensitive/selective 3D nanostructured immunoparticle-based interface on a multichannel sensor array for detecting amyloid-beta in Alzheimer's disease

Liu, T. C., Lee, Y. C., Ko, C. Y., Liu, R. S., Ke, C. C., Lo, Y. C., Hong, P. S., Chu, C. Y., Chang, C. W., Wu, P. W., Chen, Y. Y. & Chen, S. Y., Jan 1 2018, In : Theranostics. 8, 15, p. 4210-4225 16 p.

Research output: Contribution to journalArticle

Amyloid
Fibroins
Alzheimer Disease
Silk
Peptides
3 Citations (Scopus)

Hypoxia-Preconditioned Human Umbilical Vein Endothelial Cells Protect Against Neurovascular Damage After Hypoxic Ischemia in Neonatal Brain

Lee, Y. C., Chang, Y. C., Wu, C. C. & Huang, C. C., Feb 19 2018, (Accepted/In press) In : Molecular Neurobiology. p. 1-15 15 p.

Research output: Contribution to journalArticle

Human Umbilical Vein Endothelial Cells
Ischemia
Brain
Hypoxia
Genes
2 Citations (Scopus)

Individualized prediction of schizophrenia based on the whole-brain pattern of altered white matter tract integrity

Chen, Y. J., Liu, C. M., Hsu, Y. C., Lo, Y. C., Hwang, T. J., Hwu, H. G., Lin, Y. T. & Tseng, W. Y. I., Jan 1 2018, In : Human Brain Mapping. 39, 1, p. 575-587 13 p.

Research output: Contribution to journalArticle

Schizophrenia
Brain
Masks
ROC Curve
Biomarkers
1 Citation (Scopus)

LGK974, a PORCUPINE inhibitor, mitigates cytotoxicity in an in vitro model of Parkinson's disease by interfering with the WNT/β-CATENIN pathway

Yang, J. M., Huang, H. M., Cheng, J. J., Huang, C. L., Lee, Y. C., Chiou, C. T., Huang, H. T., Huang, N. K. & Yang, Y. C., Dec 1 2018, In : Toxicology. 410, p. 65-72 8 p.

Research output: Contribution to journalArticle

Paraquat
Cytotoxicity
Parkinson Disease
Dopaminergic Neurons
Cell death
17 Citations (Scopus)

LRP10 genetic variants in familial Parkinson's disease and dementia with Lewy bodies: a genome-wide linkage and sequencing study

International Parkinsonism Genetics Network, Jul 1 2018, In : The Lancet Neurology. 17, 7, p. 597-608 12 p.

Research output: Contribution to journalArticle

Lewy Body Disease
Parkinson Disease
Genome
Dementia
Genes
5 Citations (Scopus)
Ubiquitination
Glioma
Glioblastoma
Stem Cells
temozolomide
5 Citations (Scopus)

Nano-diamino-tetrac (NDAT) inhibits PD-L1 expression which is essential for proliferation in oral cancer cells

Lin, S. J., Chin, Y. T., Ho, Y., Chou, S. Y., Sh Yang, Y. C., Nana, A. W., Su, K. W., Lim, Y. T., Wang, K., Lee, SY. Y., Shih, Y. J., Chen, Y. R., Whang-Peng, J., Davis, P. J., Lin, H. Y. & Fu, E., Oct 1 2018, In : Food and Chemical Toxicology. 120, p. 1-11 11 p.

Research output: Contribution to journalArticle

Mouth Neoplasms
Cells
death
Ligands
phosphatidylinositol 3-kinase

Nck2 is essential for limb trajectory selection by spinal motor axons

Chang, C. J., Chang, M. Y., Lee, Y. C., Chen, K. Y., Hsu, T. I., Wu, Y. H., Chuang, J. Y. & Kao, T. J., Sep 1 2018, In : Developmental Dynamics. 247, 9, p. 1043-1056 14 p.

Research output: Contribution to journalArticle

Axons
Extremities
Motor Neurons
Ephrins
Neurites

Nicotine-induced conditional place preference is affected by head injury: Correlation with dopamine release in the nucleus accumbens shell

Chen, Y. H., Kuo, T. T., Huang, E. Y. K., Hoffer, B. J., Kao, J. H., Chou, Y. C., Chiang, Y. H. & Miller, J., Oct 1 2018, In : International Journal of Neuropsychopharmacology. 21, 10, p. 949-961 13 p.

Research output: Contribution to journalArticle

Nucleus Accumbens
Nicotine
Craniocerebral Trauma
Dopamine
Percussion
2 Citations (Scopus)

PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model

Chiu, C. C., Lu, C. S., Weng, Y. H., Chen, Y. L., Huang, Y. Z., Chen, R. S., Cheng, Y. C., Huang, Y. C., Liu, Y. C., Lai, S. C., Lin, K. J., Lin, Y. W., Chen, Y. J., Chen, C. L., Yeh, T. H. & Wang, H. L., Jan 1 2018, (Accepted/In press) In : Molecular Neurobiology.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Dopaminergic Neurons
Substantia Nigra
Mutation
Parkinson Disease
2 Citations (Scopus)

Pomalidomide ameliorates H2O2-induced oxidative stress injury and cell death in rat primary cortical neuronal cultures by inducing anti-oxidative and anti-apoptosis effects

Tsai, Y. R., Chang, C. F., Lai, J. H., Wu, J. C. C., Chen, Y. H., Kang, S. J., Hoffer, B. J., Tweedie, D., Luo, W., Greig, N. H., Chiang, Y. H. & Chen, K. Y., Oct 19 2018, In : International Journal of Molecular Sciences. 19, 10

Research output: Contribution to journalArticle

Oxidative stress
apoptosis
Cell death
Cell culture
death

Pparα deficiency inhibits the proliferation of neuronal and glial precursors in the zebrafish central nervous system

Hsieh, Y. C., Chiang, M. C., Huang, Y. C., Yeh, T. H., Shih, H. Y., Liu, H. F., Chen, H. Y., Wang, C. P. & Cheng, Y. C., Dec 1 2018, In : Developmental Dynamics. 247, 12, p. 1264-1275 12 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Zebrafish
Neuroglia
Central Nervous System
Brain Neoplasms
2 Citations (Scopus)

Profound deficits in hippocampal synaptic plasticity after traumatic brain injury and seizure is ameliorated by prophylactic levetiracetam

Chen, Y. H., Kuo, T. T., Huang, E. Y. K., Hoffer, B. J., Chou, Y. C., Chiang, Y. H., Ma, H. I. & Miller, J. P., Feb 20 2018, In : Oncotarget. 9, 14, p. 11515-11527 13 p.

Research output: Contribution to journalArticle

etiracetam
Neuronal Plasticity
Seizures
Percussion
Hippocampus
1 Citation (Scopus)

Prototype Deep Brain Stimulation System with Closed-Loop Control Feedback for Modulating Bladder Functions in Traumatic Brain Injured Animals

Jen, E., Lin, C. W., Hsieh, T. H., Chiu, Y. C., Lu, T. C., Chen, S. C., Chen, M. C. & Peng, C. W., Jun 1 2018, In : Journal of Medical and Biological Engineering. 38, 3, p. 337-349 13 p.

Research output: Contribution to journalArticle

Feedback control
Brain
Animals
Feedback
Surface mount technology
4 Citations (Scopus)

Resveratrol inhibits human leiomyoma cell proliferation via crosstalk between integrin αvβ3 and IGF-1R

Ho, Y., SH Yang, Y. C., Chin, Y. T., Chou, S. Y., Chen, Y. R., Shih, Y. J., Whang-Peng, J., Changou, C. A., Liu, H. L., Lin, S. J., Tang, H. Y., Lin, H. Y. & Davis, P. J., Oct 1 2018, In : Food and Chemical Toxicology. 120, p. 346-355 10 p.

Research output: Contribution to journalArticle

resveratrol
integrins
Myoma
Cell proliferation
somatomedins
1 Citation (Scopus)

Role of Nogo Receptor-1 for Recovery of Balance, Cognition, and Emotion after Mild Traumatic Brain Injury in Mice

Lai, J-H., Karlsson, T. E., Wu, J. C-C., Huang, C-Z., Chen, Y-H., Kang, S-J., Brodin, A. T. S., Hoffer, B. J., Olson, L., Chiang, Y-H. & Chen, K-Y., Nov 17 2018, In : Journal of Neurotrauma.

Research output: Contribution to journalArticle

Brain Concussion
Cognition
Emotions
Doxycycline
Aptitude