The Ph.D. Program for Neural Regenerative Medicine

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output 2000 2019

2018
5 Citations (Scopus)

Nano-diamino-tetrac (NDAT) inhibits PD-L1 expression which is essential for proliferation in oral cancer cells

Lin, S. J., Chin, Y. T., Ho, Y., Chou, S. Y., Sh Yang, Y. C., Nana, A. W., Su, K. W., Lim, Y. T., Wang, K., Lee, SY. Y., Shih, Y. J., Chen, Y. R., Whang-Peng, J., Davis, P. J., Lin, H. Y. & Fu, E., Oct 1 2018, In : Food and Chemical Toxicology. 120, p. 1-11 11 p.

Research output: Contribution to journalArticle

Mouth Neoplasms
Cells
death
Ligands
phosphatidylinositol 3-kinase

Nck2 is essential for limb trajectory selection by spinal motor axons

Chang, C. J., Chang, M. Y., Lee, Y. C., Chen, K. Y., Hsu, T. I., Wu, Y. H., Chuang, J. Y. & Kao, T. J., Sep 1 2018, In : Developmental Dynamics. 247, 9, p. 1043-1056 14 p.

Research output: Contribution to journalArticle

Axons
Extremities
Motor Neurons
Ephrins
Neurites

Neural Decoding Forelimb Trajectory Using Evolutionary Neural Networks with Feedback-Error-Learning Schemes

Lin, Y. C., Chou, C., Yang, S. H., Lai, H. Y., Lo, Y. C. & Chen, Y. Y., Oct 26 2018, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Institute of Electrical and Electronics Engineers Inc., Vol. 2018-July. p. 2539-2542 4 p. 8512775

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Brain-Computer Interfaces
Forelimb
Biomechanical Phenomena
Decoding
Trajectories

Nicotine-induced conditional place preference is affected by head injury: Correlation with dopamine release in the nucleus accumbens shell

Chen, Y. H., Kuo, T. T., Huang, E. Y. K., Hoffer, B. J., Kao, J. H., Chou, Y. C., Chiang, Y. H. & Miller, J., Oct 1 2018, In : International Journal of Neuropsychopharmacology. 21, 10, p. 949-961 13 p.

Research output: Contribution to journalArticle

Nucleus Accumbens
Nicotine
Craniocerebral Trauma
Dopamine
Percussion
3 Citations (Scopus)

PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model

Chiu, C. C., Lu, C. S., Weng, Y. H., Chen, Y. L., Huang, Y. Z., Chen, R. S., Cheng, Y. C., Huang, Y. C., Liu, Y. C., Lai, S. C., Lin, K. J., Lin, Y. W., Chen, Y. J., Chen, C. L., Yeh, T. H. & Wang, H. L., Jan 1 2018, (Accepted/In press) In : Molecular Neurobiology.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Dopaminergic Neurons
Substantia Nigra
Mutation
Parkinson Disease
2 Citations (Scopus)

Pomalidomide ameliorates H2O2-induced oxidative stress injury and cell death in rat primary cortical neuronal cultures by inducing anti-oxidative and anti-apoptosis effects

Tsai, Y. R., Chang, C. F., Lai, J. H., Wu, J. C. C., Chen, Y. H., Kang, S. J., Hoffer, B. J., Tweedie, D., Luo, W., Greig, N. H., Chiang, Y. H. & Chen, K. Y., Oct 19 2018, In : International Journal of Molecular Sciences. 19, 10

Research output: Contribution to journalArticle

Oxidative stress
apoptosis
Cell death
Cell culture
death

Pparα deficiency inhibits the proliferation of neuronal and glial precursors in the zebrafish central nervous system

Hsieh, Y. C., Chiang, M. C., Huang, Y. C., Yeh, T. H., Shih, H. Y., Liu, H. F., Chen, H. Y., Wang, C. P. & Cheng, Y. C., Dec 1 2018, In : Developmental Dynamics. 247, 12, p. 1264-1275 12 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Zebrafish
Neuroglia
Central Nervous System
Brain Neoplasms
2 Citations (Scopus)

Profound deficits in hippocampal synaptic plasticity after traumatic brain injury and seizure is ameliorated by prophylactic levetiracetam

Chen, Y. H., Kuo, T. T., Huang, E. Y. K., Hoffer, B. J., Chou, Y. C., Chiang, Y. H., Ma, H. I. & Miller, J. P., Feb 20 2018, In : Oncotarget. 9, 14, p. 11515-11527 13 p.

Research output: Contribution to journalArticle

etiracetam
Neuronal Plasticity
Seizures
Percussion
Hippocampus
1 Citation (Scopus)

Prototype Deep Brain Stimulation System with Closed-Loop Control Feedback for Modulating Bladder Functions in Traumatic Brain Injured Animals

Jen, E., Lin, C. W., Hsieh, T. H., Chiu, Y. C., Lu, T. C., Chen, S. C., Chen, M. C. & Peng, C. W., Jun 1 2018, In : Journal of Medical and Biological Engineering. 38, 3, p. 337-349 13 p.

Research output: Contribution to journalArticle

Feedback control
Brain
Animals
Feedback
Surface mount technology
5 Citations (Scopus)

Resveratrol inhibits human leiomyoma cell proliferation via crosstalk between integrin αvβ3 and IGF-1R

Ho, Y., SH Yang, Y. C., Chin, Y. T., Chou, S. Y., Chen, Y. R., Shih, Y. J., Whang-Peng, J., Changou, C. A., Liu, H. L., Lin, S. J., Tang, H. Y., Lin, H. Y. & Davis, P. J., Oct 1 2018, In : Food and Chemical Toxicology. 120, p. 346-355 10 p.

Research output: Contribution to journalArticle

resveratrol
integrins
Myoma
Cell proliferation
somatomedins
2 Citations (Scopus)

Role of Nogo Receptor-1 for Recovery of Balance, Cognition, and Emotion after Mild Traumatic Brain Injury in Mice

Lai, J-H., Karlsson, T. E., Wu, J. C-C., Huang, C-Z., Chen, Y-H., Kang, S-J., Brodin, A. T. S., Hoffer, B. J., Olson, L., Chiang, Y-H. & Chen, K-Y., Nov 17 2018, In : Journal of Neurotrauma.

Research output: Contribution to journalArticle

Brain Concussion
Cognition
Emotions
Doxycycline
Aptitude
4 Citations (Scopus)
Glioblastoma
Amyloid
Integrins
Serum
Glioma
2 Citations (Scopus)
Cerebral Hemorrhage
stroke
blood lipids
hemorrhage
Cholesterol
2 Citations (Scopus)
Drug infusion
Infusion Pumps
Glucose Intolerance
Insulin
Glucose

The applications of smart mobile device for detecting balance dysfunction in individuals with down syndrome

Hsieh, T. H., Peng, C. W., Chen, K. Y., Huang, Y. Z., Lin, Y. H., Zhong, W. Z., Liang, J. I., Zhao, J., Cheng, C. Y., Chang, Y. J., Cheng, C. H. & Chuang, Y. F., Feb 1 2018, In : Biomedical Engineering - Applications, Basis and Communications. 30, 1, 1850007.

Research output: Contribution to journalArticle

Mobile Applications
Down Syndrome
Mobile devices
Equipment and Supplies
Nervous System Diseases
5 Citations (Scopus)

The association between BDNF Val66Met polymorphism and emotional symptoms after mild traumatic brain injury

Wang, Y. J., Chen, K. Y., Kuo, L. N., Wang, W. C., Hsu, Y. W., Wong, H. S. C., Lin, C. M., Liao, K. H., Zhang, Y. F., Chiang, Y. H. & Chang, W. C., Jan 22 2018, In : BMC Medical Genetics. 19, 1, 13.

Research output: Contribution to journalArticle

Brain Concussion
Brain-Derived Neurotrophic Factor
Equipment and Supplies
Alleles
Depression
7 Citations (Scopus)
Glucosides
Doxorubicin
antioxidant
Antioxidants
Focal Segmental Glomerulosclerosis

The use of intensity-based Doppler variance method for single vessel response to functional neurovascular activation

Kuo, W. C., Kuo, Y. M., Syu, J. P., Wang, H. L., Lai, C. M., Chen, J. W., Lo, Y. C. & Chen, Y. Y., Jul 1 2018, In : Journal of Biophotonics. 11, 7, e201800017.

Research output: Contribution to journalArticle

vessels
Blood
Chemical activation
Optical tomography
Optical Coherence Tomography
1 Citation (Scopus)

Upregulation of Znf179 acetylation by SAHA protects cells against oxidative stress

Wu, C. C., Lee, P. T., Kao, T. J., Chou, S. Y., Su, R. Y., Lee, Y. C., Yeh, S. H., Liou, J. P., Hsu, T. I., Su, T. P., Chuang, C. K., Chang, W. C. & Chuang, J. Y., Oct 1 2018, In : Redox Biology. 19, p. 74-80 7 p.

Research output: Contribution to journalArticle

Acetylation
Oxidative stress
Zinc Fingers
Zinc
Oxidative Stress
6 Citations (Scopus)

USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy

Wang, Y. C., Wu, Y. S., Hung, C. Y., Wang, S. A., Young, M. J., Hsu, T. I. & Hung, J. J., Dec 1 2018, In : Nature Communications. 9, 1, 3996.

Research output: Contribution to journalArticle

Open Access
Tumor Microenvironment
Macrophages
Tumors
Interleukin-6
tumors
6 Citations (Scopus)

Voluntary physical exercise improves subsequent motor and cognitive impairments in a rat model of parkinson’s disease

Hsueh, S. C., Chen, K. Y., Lai, J. H., Wu, C. C., Yu, Y. W., Luo, Y., Hsieh, T. H. & Chiang, Y. H., Feb 8 2018, In : International Journal of Molecular Sciences. 19, 2, 508.

Research output: Contribution to journalArticle

Parkinson disease
impairment
physical exercise
Oxidopamine
rats
3 Citations (Scopus)

Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology

Lee, Y-C., Huang, W-C., Lin, J-H., Kao, T-J., Lin, H-C., Lee, K-H., Lin, H-C., Shen, C-K. J., Chang, W-C. & Huang, C-C., Nov 8 2018, In : Journal of Biomedical Science. 25, 1, p. 76 1 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Pathology
Amyotrophic Lateral Sclerosis
Frontotemporal Lobar Degeneration
Proteins
2019

Altered frontal aslant tracts as a heritable neural basis of social communication deficits in autism spectrum disorder: A sibling study using tract-based automatic analysis

Lo, Y. C., Chen, Y. J., Hsu, Y. C., Chien, Y. L., Gau, S. S. F. & Tseng, W. Y. I., 2019, In : Autism Research.

Research output: Contribution to journalArticle

Siblings
Anisotropy
Communication
Phenotype
Diffusion Magnetic Resonance Imaging
Open Access
Acid Sensing Ion Channels
Brain Concussion
Dizziness
Alleles
Genes

BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine

Chao, P. K., Chang, H. F., Chang, W. T., Yeh, T. K., Ou, L. C., Chuang, J. Y., Tsu-An Hsu, J., Tao, P. L., Loh, H. H., Shih, C., Ueng, S. H. & Yeh, S. H., Jan 1 2019, In : Neuropharmacology. 107678.

Research output: Contribution to journalArticle

Peptide Receptors
mu Opioid Receptor
Morphine
Naloxone
Arrestin

Cerebro-Cerebellar Pathways for Verbal Working Memory

Sobczak-Edmans, M., Lo, Y-C., Hsu, Y-C., Chen, Y-J., Kwok, F. Y., Chuang, K-H., Tseng, W-Y. I. & Chen, S. H. A., 2019, In : Frontiers in Human Neuroscience. 12, p. 530

Research output: Contribution to journalArticle

Short-Term Memory
Cerebellum
Parietal Lobe
Pons
Prefrontal Cortex

Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice

Chao, P. K., Chang, H. F., Ou, L. C., Chuang, J. Y., Lee, P. T., Chang, W. T., Chen, S. C., Ueng, S. H., Hsu, J. T. A., Tao, P. L., Law, P. Y., Loh, H. H. & Yeh, S. H., Dec 1 2019, In : Scientific Reports. 9, 1, 2405.

Research output: Contribution to journalArticle

mu Opioid Receptor
Endocytosis
Morphine
Ligands
Morphine Dependence
1 Citation (Scopus)
temozolomide
Dehydroepiandrosterone
Glioblastoma
Acetylation
Phosphorylation
Neuronal Plasticity
Electric Impedance
Brain
Motor Evoked Potentials
Transcranial Magnetic Stimulation
Embryonal Carcinoma Stem Cells
Neural Stem Cells
Zinc Fingers
Transcription
Zinc

Editorial: Risk factors and outcome predicating biomarker of neurodegenerative diseases

Hu, C. J. & Octave, J. N., Jan 1 2019, In : Frontiers in Neurology. 10, February, 45.

Research output: Contribution to journalReview article

Open Access
Neurodegenerative Diseases
Parkinson Disease
Alzheimer Disease
Biomarkers
1 Citation (Scopus)
Open Access
homing
brain damage
stem cells
fibroblasts
Fibroblasts

Gene-Embedded Nanostructural Biotic-Abiotic Optoelectrode Arrays Applied for Synchronous Brain Optogenetics and Neural Signal Recording

Huang, W. C., Chi, H. S., Lee, Y. C., Lo, Y. C., Liu, T. C., Chiang, M. Y., Chen, H. Y., Li, S. J., Chen, Y. Y. & Chen, S. Y., Mar 27 2019, In : ACS Applied Materials and Interfaces. 11, 12, p. 11270-11282 13 p.

Research output: Contribution to journalArticle

Brain
Genes
Polyethyleneimine
Neurotensin
Plasmids
Open Access
Cell Cycle Proteins
Epithelial-Mesenchymal Transition
regulators
Prostatic Neoplasms
genes

Increased short- and long-term risk of sleep disorders in people with traumatic brain injury

Wang, Y. J., Chang, W. C., Wu, C. C., Chiang, Y. H., Chiu, W. T., Chen, K. Y. & Chang, W. P., Jan 1 2019, (Accepted/In press) In : Neuropsychological Rehabilitation.

Research output: Contribution to journalArticle

Sleep
Cohort Studies
Brain Concussion
Brain Diseases
Traumatic Brain Injury

Ketamine ameliorates severe traumatic event-induced antidepressant-resistant depression in a rat model through ERK activation

Lee, C. W., Chen, Y. J., Wu, H. F., Chung, Y. J., Lee, Y. C., Li, C. T. & Lin, H. C., Jul 13 2019, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 93, p. 102-113 12 p.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
Ketamine
Antidepressive Agents
Serotonin Uptake Inhibitors
Depression
1 Citation (Scopus)

Leukemia Inhibitory Factor Promotes Castration-resistant Prostate Cancer and Neuroendocrine Differentiation by Activated ZBTB46

Liu, Y-N., Niu, S., Chen, W-Y., Zhang, Q., Tao, Y., Chen, W-H., Jiang, K-C., Chen, X., Shi, H., Liu, A., Li, J., Li, Y., Lee, Y-C., Zhang, X. & Huang, J., Apr 8 2019, In : Clinical cancer research : an official journal of the American Association for Cancer Research.

Research output: Contribution to journalArticle

Leukemia Inhibitory Factor
Castration
Prostatic Neoplasms
Androgens
Therapeutics

Morphological control of mitochondria as the novel mechanism of Gastrodia elata in attenuating mutant huntingtin-induced protein aggregations

Huang, N. K., Lin, C. C., Lin, Y. L., Huang, C. L., Chiou, C. T., Lee, Y. C., Lee, S. Y., Huang, H. T. & Yang, Y. C., Jun 1 2019, In : Phytomedicine. 59, 152756.

Research output: Contribution to journalArticle

Gastrodia
Mutant Proteins
Huntington Disease
Mitochondria
Mitochondrial Dynamics

MR imaging central thalamic deep brain stimulation restored autistic-like social deficits in the rat

Lin, T. C., Lo, Y. C., Lin, H. C., Li, S. J., Lin, S. H., Wu, H. F., Chu, M. C., Lee, C. W., Lin, I. C., Chang, C. W., Liu, Y. C., Chen, T. C., Lin, Y. J., Ian Shih, Y. Y. & Chen, Y. Y., Jan 1 2019, In : Brain Stimulation.

Research output: Contribution to journalArticle

Deep Brain Stimulation
Thalamic Nuclei
Magnetic Resonance Imaging
Interpersonal Relations
Brain
1 Citation (Scopus)
Coumarins
Cell death
Colonic Neoplasms
Cell Death
Cells

Pomalidomide Reduces Ischemic Brain Injury in Rodents

Tsai, Y. R., Tweedie, D., Navas-Enamorado, I., Scerba, M. T., Chang, C. F., Lai, J. H., Wu, J. C. C., Chen, Y. H., Kang, S. J., Hoffer, B. J., de Cabo, R., Greig, N. H., Chiang, Y. H. & Chen, K. Y., Apr 1 2019, In : Cell Transplantation. 28, 4, p. 439-450 12 p.

Research output: Contribution to journalArticle

Open Access
Brain Injuries
Rodentia
Brain
Rats
Surface active agents

Potential therapeutic effect of curcumin, a natural mTOR inhibitor, in tuberous sclerosis complex

Kuo, C. J., Huang, C. C., Chou, S. Y., Lo, Y. C., Kao, T. J., Huang, N. K., Lin, C., Lin, H. C., Lin, H. C. & Lee, Y. C., Feb 15 2019, In : Phytomedicine. 54, p. 132-139 8 p.

Research output: Contribution to journalArticle

Tuberous Sclerosis
Curcumin
Therapeutic Uses
Memory Disorders
Lipids
1 Citation (Scopus)

Prevalence and clinical characteristics of stroke patients with p.R544C NOTCH3 mutation in Taiwan

Tang, S. C., Chen, Y. R., Chi, N. F., Chen, C. H., Cheng, Y. W., Hsieh, F. I., Hsieh, Y. C., Yeh, H. L., Sung, P. S., Hu, C. J., Chern, C. M., Lin, H. J., Lien, L. M., Peng, G. S., Chiou, H. Y. & Jeng, J. S., Jan 1 2019, In : Annals of Clinical and Translational Neurology. 6, 1, p. 121-128 8 p.

Research output: Contribution to journalArticle

Taiwan
Stroke
Mutation
Cerebral Hemorrhage
CADASIL

Promyelocytic leukemia zinc finger is involved in the formation of deep layer cortical neurons

Lin, H. C., Ching, Y. H., Huang, C. C., Pao, P. C., Lee, Y. H., Chang, W. C., Kao, T. J. & Lee, Y. C., Apr 26 2019, In : Journal of Biomedical Science. 26, 1, 30.

Research output: Contribution to journalArticle

Open Access
Zinc Fingers
Neurons
Zinc
Leukemia
Brain

Psychometric Evaluation of Anxiety, Depression, and Sleep Quality after a Mild Traumatic Brain Injury: A Longitudinal Study

Ma, H-P., Chen, P-S., Wong, C-S., Chang, C-F., Ou, J-C., Tsai, Y-R., Chiu, W-T., Tsai, S-H., Liao, K-H., Chiang, Y-H., Wang, J-Y., Chen, K-Y. & Wu, J. C-C., 2019, In : Behavioural Neurology. 2019, p. 4364592

Research output: Contribution to journalArticle

Brain Concussion
Psychometrics
Longitudinal Studies
Sleep
Anxiety

Sp1 in Astrocyte Is Important for Neurite Outgrowth and Synaptogenesis

Hung, C. Y., Hsu, T. I., Chuang, J. Y., Su, T. P., Chang, W. C. & Hung, J. J., Jan 1 2019, In : Molecular Neurobiology.

Research output: Contribution to journalArticle

Astrocytes
Synapses
Hippocampus
Neurons
Toll-Like Receptor 2

Unsupervised Classification of Cerebrospinal Fluid by Statistical Indicators

Lee, K. R., Yeh, Y. X., Wu, C. C., Lin, J. & Chiang, Y. H., Jan 16 2019, Proceedings - 2018 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2018. Institute of Electrical and Electronics Engineers Inc., p. 3827-3832 6 p. 8616645. (Proceedings - 2018 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2018).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cerebrospinal fluid
Cerebrospinal Fluid
Spinal Stenosis
Spinal Canal
Canals

Voluntary exercise delays progressive deterioration of markers of metabolism and behavior in a mouse model of Parkinson's disease

Lai, J. H., Chen, K. Y., Wu, J. C. C., Olson, L., Brené, S., Huang, C. Z., Chen, Y. H., Kang, S. J., Ma, K. H., Hoffer, B. J., Hsieh, T. H. & Chiang, Y. H., Oct 1 2019, In : Brain Research. 1720, 146301.

Research output: Contribution to journalReview article

Open Access
Parkinson Disease
Dopamine
Exercise
Dopamine Plasma Membrane Transport Proteins
Membrane Transport Proteins