The Ph.D. Program for Neural Regenerative Medicine

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output 2000 2020

5 Citations (Scopus)

Location and level of Etk expression in neurons are associated with varied severity of traumatic brain injury

Wu, J. C. C., Chen, K. Y., Yu, Y. W., Huang, S. W., Shih, H. M., Chiu, W. T., Chiang, Y. H. & Shiau, C. Y., Jun 18 2012, In : PLoS One. 7, 6, e39226.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Neurons
tyrosine
Brain
phosphotransferases (kinases)
25 Citations (Scopus)

LRP10 genetic variants in familial Parkinson's disease and dementia with Lewy bodies: a genome-wide linkage and sequencing study

International Parkinsonism Genetics Network, Jul 1 2018, In : The Lancet Neurology. 17, 7, p. 597-608 12 p.

Research output: Contribution to journalArticle

Lewy Body Disease
Parkinson Disease
Genome
Dementia
Genes
3 Citations (Scopus)

Mapping the naloxone binding sites on the mu-opioid receptor using cell-based photocrosslinkers

Ke, Y. Y., Huang, Y. H., Chien, W. C., Loh, H. H., Chuang, J. Y. & Yeh, S. H., Mar 1 2017, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1865, 3, p. 336-343 8 p.

Research output: Contribution to journalArticle

mu Opioid Receptor
Naloxone
Binding Sites
Morphine
Amber
6 Citations (Scopus)
Ubiquitination
Glioma
Glioblastoma
Stem Cells
temozolomide
2 Citations (Scopus)

Medical treatment guidelines for acute migraine attacks

Treatment Guideline Subcommittee of Taiwan Headache Society, Jan 1 2017, In : Acta Neurologica Taiwanica. 26, 2, p. 78-96 19 p.

Research output: Contribution to journalArticle

Migraine Disorders
Guidelines
Tryptamines
Anti-Inflammatory Agents
Pharmaceutical Preparations
2 Citations (Scopus)

Medical treatment guidelines for preventive treatment of migraine

Huang, T. C., Lai, T. H., Wang, S. J., Wang, P. J., Wang, Y. F., Lee, L. H., Lin, K. C., Wu, Z. A., Shih, C. S., Hsu, Y. C., Chen, Y. Y., Chen, W. H., Chen, W. T., Chen, P. K., Huang, T. C., Fu, J. L., Yang, C. P., Yeh, T. H., Liao, Y. C., Lai, T. H. & 3 others, Tsai, J. J., Lu, S. R. & Treatment Guideline Subcommittee of Taiwan Headache Society, Jan 1 2017, In : Acta Neurologica Taiwanica. 26, 1, p. 33-35 3 p.

Research output: Contribution to journalArticle

Migraine Disorders
Guidelines
Taiwan
Therapeutics
Anti-Inflammatory Agents
37 Citations (Scopus)

Metabolism and mis-metabolism of the neuropathological signature protein TDP-43

Huang, C. C., Bose, J. K., Majumder, P., Lee, K. H., Huang, J. T. J., Huang, J. K. & Shen, C. K. J., 2014, In : Journal of Cell Science. 127, 14, p. 3024-3038 15 p.

Research output: Contribution to journalArticle

TDP-43 Proteinopathies
Autophagy
Caspases
Frontotemporal Lobar Degeneration
Proteins
8 Citations (Scopus)

Methamphetamine potentiates behavioral and electrochemical responses after mild traumatic brain injury in mice

Shen, H., Harvey, B. K., Chiang, Y. H., Pick, C. G. & Wang, Y., Jan 12 2011, In : Brain Research. 1368, p. 248-253 6 p.

Research output: Contribution to journalArticle

Brain Concussion
Methamphetamine
3,4-Dihydroxyphenylacetic Acid
Locomotion
Corpus Striatum

Methods for Identification, Assessment, Prevention, and Therapy of Cancer.

Lee, Y-C., Yuen, P-Y., Huang, Y-H. & Wu, H-C., 2007

Research output: Patent

Biomarkers
Carcinoma
Neoplasms
Squamous Cell Carcinoma
Adenocarcinoma
29 Citations (Scopus)

Microglia retard dengue virus-induced acute viral encephalitis

Tsai, T. T., Chen, C. L., Lin, Y. S., Chang, C. P., Tsai, C. C., Cheng, Y. L., Huang, C. C., Ho, C. J., Lee, Y. C., Lin, L. T., Jhan, M. K. & Lin, C. F., Jun 9 2016, In : Scientific Reports. 6, 27670.

Research output: Contribution to journalArticle

Viral Encephalitis
Dengue Virus
Microglia
Virus Diseases
Cytotoxic T-Lymphocytes
68 Citations (Scopus)

MicroRNA-494 reduces ATF3 expression and promotes AKI

Lan, Y. F., Chen, H. H., Lai, P. F., Cheng, C. F., Huang, Y. T., Lee, Y. C., Chen, T-W. & Lin, H., 2012, In : Journal of the American Society of Nephrology. 23, 12, p. 2012-2023 12 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
MicroRNAs
Kidney
Reperfusion
Ischemia
30 Citations (Scopus)

Minocycline prevents paraquat-induced cell death through attenuating endoplasmic reticulum stress and mitochondrial dysfunction

Huang, C. L., Lee, Y. C., Yang, Y. C., Kuo, T. Y. & Huang, N. K., Mar 25 2012, In : Toxicology Letters. 209, 3, p. 203-210 8 p.

Research output: Contribution to journalArticle

Minocycline
Paraquat
Endoplasmic Reticulum Stress
Cell death
Cell Death

Modulation of Theta-Band Local Field Potential Oscillations Across Brain Networks With Central Thalamic Deep Brain Stimulation to Enhance Spatial Working Memory

Chang, C. W., Lo, Y. C., Lin, S. H., Yang, S. H., Lin, H. C., Lin, T. C., Li, S. J., Hsieh, C. C. J., Ro, V., Chung, Y. J., Chang, Y. C., Lee, C. W., Kuo, C. H., Chen, S. Y. & Chen, Y. Y., Nov 26 2019, In : Frontiers in Neuroscience. 13, 1269.

Research output: Contribution to journalArticle

Open Access
Deep Brain Stimulation
Thalamus
Short-Term Memory
Brain
Hippocampus
13 Citations (Scopus)

Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling

Lee, P. T., Chao, P. K., Ou, L. C., Chuang, J. Y., Lin, Y. C., Chen, S. C., Chang, H. F., Law, P. Y., Loh, H. H., Chao, Y. S., Su, T. P. & Yeh, S. H., Dec 1 2014, In : Nucleic Acids Research. 42, 21, p. 13012-13025 14 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoprotein K
Opioid Receptors
Morphine
Neurons
mu Opioid Receptor
1 Citation (Scopus)

Morphological control of mitochondria as the novel mechanism of Gastrodia elata in attenuating mutant huntingtin-induced protein aggregations

Huang, N. K., Lin, C. C., Lin, Y. L., Huang, C. L., Chiou, C. T., Lee, Y. C., Lee, S. Y., Huang, H. T. & Yang, Y. C., Jun 1 2019, In : Phytomedicine. 59, 152756.

Research output: Contribution to journalArticle

Gastrodia
Mutant Proteins
Huntington Disease
Mitochondria
Mitochondrial Dynamics
41 Citations (Scopus)

MPTP-induced deficits in striatal synaptic plasticity are prevented by glial cell line-derived neurotrophic factor expressed via an adeno-associated viral vector

Chen, Y. H., Harvey, B. K., Hoffman, A. F., Wang, Y., Chiang, Y. H. & Lupica, C. R., Jan 2008, In : FASEB Journal. 22, 1, p. 261-275 15 p.

Research output: Contribution to journalArticle

Glial Cell Line-Derived Neurotrophic Factor
Corpus Striatum
Neuronal Plasticity
neurotrophins
neuroglia

MR imaging central thalamic deep brain stimulation restored autistic-like social deficits in the rat

Lin, T. C., Lo, Y. C., Lin, H. C., Li, S. J., Lin, S. H., Wu, H. F., Chu, M. C., Lee, C. W., Lin, I. C., Chang, C. W., Liu, Y. C., Chen, T. C., Lin, Y. J., Ian Shih, Y. Y. & Chen, Y. Y., Jan 1 2019, In : Brain Stimulation.

Research output: Contribution to journalArticle

Deep Brain Stimulation
Thalamic Nuclei
Magnetic Resonance Imaging
Interpersonal Relations
Brain
4 Citations (Scopus)
Taiwan
Breast Neoplasms
DNA Mismatch Repair
Single Nucleotide Polymorphism
Luciferases
7 Citations (Scopus)

Nano-diamino-tetrac (NDAT) inhibits PD-L1 expression which is essential for proliferation in oral cancer cells

Lin, S. J., Chin, Y. T., Ho, Y., Chou, S. Y., Sh Yang, Y. C., Nana, A. W., Su, K. W., Lim, Y. T., Wang, K., Lee, SY. Y., Shih, Y. J., Chen, Y. R., Whang-Peng, J., Davis, P. J., Lin, H. Y. & Fu, E., Oct 1 2018, In : Food and Chemical Toxicology. 120, p. 1-11 11 p.

Research output: Contribution to journalArticle

Mouth Neoplasms
Cells
death
Ligands
phosphatidylinositol 3-kinase

Nck2 is essential for limb trajectory selection by spinal motor axons

Chang, C. J., Chang, M. Y., Lee, Y. C., Chen, K. Y., Hsu, T. I., Wu, Y. H., Chuang, J. Y. & Kao, T. J., Sep 1 2018, In : Developmental Dynamics. 247, 9, p. 1043-1056 14 p.

Research output: Contribution to journalArticle

Axons
Extremities
Motor Neurons
Ephrins
Neurites
62 Citations (Scopus)

Netrin1 Produced by Neural Progenitors, Not Floor Plate Cells, Is Required for Axon Guidance in the Spinal Cord

Varadarajan, S. G., Kong, J. H., Phan, K. D., Kao, T. J., Panaitof, S. C., Cardin, J., Eltzschig, H., Kania, A., Novitch, B. G. & Butler, S. J., May 17 2017, In : Neuron. 94, 4, p. 790-799.e3

Research output: Contribution to journalArticle

Axons
Spinal Cord
Chemotactic Factors
Chemotaxis
Growth

Neural Decoding Forelimb Trajectory Using Evolutionary Neural Networks with Feedback-Error-Learning Schemes

Lin, Y. C., Chou, C., Yang, S. H., Lai, H. Y., Lo, Y. C. & Chen, Y. Y., Oct 26 2018, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Institute of Electrical and Electronics Engineers Inc., Vol. 2018-July. p. 2539-2542 4 p. 8512775

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Brain-Computer Interfaces
Forelimb
Biomechanical Phenomena
Decoding
Trajectories
3 Citations (Scopus)

Neurovascular function recovery after focal ischemic stroke by enhancing cerebral collateral circulation via peripheral stimulation-mediated interarterial anastomosis

Pan, H-C., Liao, L-D., Lo, Y-C., Chen, J-W., Wang, H-L., Yang, L., Liang, Y-W., Huang, P-Y., Yang, M-H. & Chen, Y-Y., Jul 2017, In : Neurophotonics. 4, 3, p. 035003

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Collateral Circulation
Forelimb
Recovery of Function
Stroke

Nicotine-induced conditional place preference is affected by head injury: Correlation with dopamine release in the nucleus accumbens shell

Chen, Y. H., Kuo, T. T., Huang, E. Y. K., Hoffer, B. J., Kao, J. H., Chou, Y. C., Chiang, Y. H. & Miller, J., Oct 1 2018, In : International Journal of Neuropsychopharmacology. 21, 10, p. 949-961 13 p.

Research output: Contribution to journalArticle

Nucleus Accumbens
Nicotine
Craniocerebral Trauma
Dopamine
Percussion
1 Citation (Scopus)

Nm23-H1-stabilized hnRNPA2/B1 promotes internal ribosomal entry site (IRES)-mediated translation of Sp1 in the lung cancer progression

Hung, C. Y., Wang, Y. C., Chuang, J. Y., Young, M. J., Liaw, H., Chang, W. C. & Hung, J. J., Dec 1 2017, In : Scientific Reports. 7, 1, 9166.

Research output: Contribution to journalArticle

Protein Biosynthesis
Lung Neoplasms
Proteins
Messenger RNA
Protein Stability
2 Citations (Scopus)
Coumarins
Cell death
Colonic Neoplasms
Cell Death
Cells
6 Citations (Scopus)

Novel use of theta burst cortical electrical stimulation for modulating motor plasticity in rats

Hsieh, T. H., Huang, Y. Z., Chen, J. J. J., Rotenberg, A., Chiang, Y-H., Chien, W. S. C., Chang, H-S., Wang, J-Y. & Peng, C-W., Feb 1 2015, In : Journal of Medical and Biological Engineering. 35, 1, p. 62-68 7 p.

Research output: Contribution to journalArticle

Motor Evoked Potentials
Electric Stimulation
Plasticity
Rats
Motor Cortex

One world for public health education

Flahault, A., Chiu, W. T., Rosenstock, L., Chiang, T. L., Patrick, W. K. & Chang, P. W. S., Oct 2010, In : Journal of Experimental and Clinical Medicine(Taiwan). 2, 5, p. 200-201 2 p.

Research output: Contribution to journalArticle

Health Education
Public Health
Global Health
7 Citations (Scopus)

Outcome prediction after moderate and severe head injury using an artificial neural network

Hsu, M-H., Li, Y. C., Chiu, W. T. & Yen, J. C., 2005, Studies in Health Technology and Informatics. Vol. 116. p. 241-245 5 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Craniocerebral Trauma
Glasgow Outcome Scale
Persistent Vegetative State
Neural networks
Brain
10 Citations (Scopus)
ovarian neoplasms
Centromere
centromeres
Ovarian Neoplasms
Tumor Biomarkers
15 Citations (Scopus)

Paraquat Induces Cell Death Through Impairing Mitochondrial Membrane Permeability

Huang, C. L., Chao, C. C., Lee, Y. C., Lu, M. K., Cheng, J. J., Yang, Y. C., Wang, V. C., Chang, W. C. & Huang, N. K., 2016, In : Molecular Neurobiology.

Research output: Contribution to journalArticle

Paraquat
Mitochondrial Membranes
Permeability
Cell Death
Apoptosis
3 Citations (Scopus)

PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model

Chiu, C. C., Lu, C. S., Weng, Y. H., Chen, Y. L., Huang, Y. Z., Chen, R. S., Cheng, Y. C., Huang, Y. C., Liu, Y. C., Lai, S. C., Lin, K. J., Lin, Y. W., Chen, Y. J., Chen, C. L., Yeh, T. H. & Wang, H. L., Jan 1 2018, (Accepted/In press) In : Molecular Neurobiology.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Dopaminergic Neurons
Substantia Nigra
Mutation
Parkinson Disease
9 Citations (Scopus)

PARK14 PLA2G6 mutants are defective in preventing rotenoneinduced mitochondrial dysfunction, ROS generation and activation of mitochondrial apoptotic pathway

Chiu, C. C., Yeh, T. H., Lu, C. S., Huang, Y. C., Cheng, Y. C., Huang, Y. Z., Weng, Y. H., Liu, Y. C., Lai, S. C., Chen, Y. L., Chen, Y. J., Chen, C. L., Chen, H. Y., Lin, Y. W. & Wang, H. L., 2017, In : Oncotarget. 8, 45, p. 79046-79060 15 p.

Research output: Contribution to journalArticle

Phospholipases A2
Rotenone
Parkinson Disease
Mitochondrial Degradation
Mitochondrial Membrane Potential
14 Citations (Scopus)

Pb2+ induced IL-8 gene expression by extracellular signal-regulated kinases and the transcription factor, activator protein 1, in human gastric carcinoma cells

Lin, Y. C., Wei, P. L., Tsai, Y. T., Wong, J. H., Chang, C. M., Wang, J. Y., Hou, M. F., Lee, Y. C., Chuang, H. Y. & Chang, W. C., Mar 1 2015, In : Environmental Toxicology. 30, 3, p. 315-322 8 p.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
Transcription Factor AP-1
Interleukin-8
Gene expression
gene expression
26 Citations (Scopus)

Pediatric traumatic brain injuries in Taiwan: An 8-year study

Tsai, W. C., Chiu, W. T., Chiou, H. Y., Choy, C-S., Hung, C. C. & Tsai, S. H., Feb 2004, In : Journal of Clinical Neuroscience. 11, 2, p. 126-129 4 p.

Research output: Contribution to journalArticle

Taiwan
Pediatrics
Wounds and Injuries
Age Groups
Motorcycles
17 Citations (Scopus)
Proteolysis
Lung Neoplasms
Carcinogenesis
Phosphorylation
Acetylation
9 Citations (Scopus)

Pin1-mediated Sp1 phosphorylation by CDK1 increases Sp1 stability and decreases its DNA-binding activity during mitosis

Yang, H. C., Chuang, J. Y., Jeng, W. Y., Liu, C. I., Wang, A. H. J., Lu, P. J., Chang, W. C. & Hung, J. J., Dec 16 2014, In : Nucleic Acids Research. 42, 22, p. 13573-13587 15 p.

Research output: Contribution to journalArticle

Mitosis
Phosphorylation
DNA
Peptides
Cell Cycle

Plasmon-Activated Water Reduces Amyloid Burden and Improves Memory in Animals with Alzheimer’s Disease

Cheng, C. H., Lin, K. J., Hong, C. T., Wu, D., Chang, H. M., Liu, C. H., Hsiao, I. T., Yang, C. P., Liu, Y. C. & Hu, C. J., Dec 1 2019, In : Scientific Reports. 9, 1, 13252.

Research output: Contribution to journalArticle

Open Access
Amyloid
Alzheimer Disease
Water
Amyloidogenic Proteins
Dementia
3 Citations (Scopus)

Pomalidomide ameliorates H2O2-induced oxidative stress injury and cell death in rat primary cortical neuronal cultures by inducing anti-oxidative and anti-apoptosis effects

Tsai, Y. R., Chang, C. F., Lai, J. H., Wu, J. C. C., Chen, Y. H., Kang, S. J., Hoffer, B. J., Tweedie, D., Luo, W., Greig, N. H., Chiang, Y. H. & Chen, K. Y., Oct 19 2018, In : International Journal of Molecular Sciences. 19, 10

Research output: Contribution to journalArticle

Oxidative stress
apoptosis
Cell death
Cell culture
death
15 Citations (Scopus)

Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat

Wang, J-Y., Huang, Y-N., Chiu, C-C., Tweedie, D., Luo, W-M., Pick, C. G., Chou, S-Y., Luo, Y., Hoffer, B. J., Greig, N. H. & Wang, J. Y., Jun 28 2016, In : Journal of Neuroinflammation. 13, 1, 168.

Research output: Contribution to journalArticle

Glutamic Acid
Wounds and Injuries
Apoptosis
Cytokines
Traumatic Brain Injury
1 Citation (Scopus)

Pomalidomide Reduces Ischemic Brain Injury in Rodents

Tsai, Y. R., Tweedie, D., Navas-Enamorado, I., Scerba, M. T., Chang, C. F., Lai, J. H., Wu, J. C. C., Chen, Y. H., Kang, S. J., Hoffer, B. J., de Cabo, R., Greig, N. H., Chiang, Y. H. & Chen, K. Y., Apr 1 2019, In : Cell Transplantation. 28, 4, p. 439-450 12 p.

Research output: Contribution to journalArticle

Open Access
Brain Injuries
Rodentia
Brain
Rats
Surface active agents
12 Citations (Scopus)

Population-based 5-year follow-up study in taiwan of osteoporosis and risk of periodontitis

Chang, W. P., Chang, W-C., Wu, M. S., Pai, J. T., Guo, Y. C., Chen, K-C., Liu, M. E., Chiu, W-T. & Hung, K-S., 2014, In : Journal of Periodontology. 85, 3

Research output: Contribution to journalArticle

Periodontitis
Taiwan
Osteoporosis
Population
Cohort Studies
10 Citations (Scopus)

Positive feedback regulation between IL10 and EGFR promotes lung cancer formation

Hsu, T. I., Wang, Y. C., Hung, C. Y., Yu, C. H., Su, W. C., Chang, W. C. & Hung, J. J., Apr 12 2016, In : Oncotarget. 7, 15, p. 20840-20854 15 p.

Research output: Contribution to journalArticle

Interleukin-10
Lung Neoplasms
Neoplasms
Carcinogenesis
Lung
13 Citations (Scopus)

Postnatal systemic inflammation exacerbates impairment of hippocampal synaptic plasticity in an animal seizure model

Chen, Y. H., Kuo, T. T., Chu, M. T., Ma, H. I., Chiang, Y. H. & Huang, E. Y. K., Jun 2013, In : NeuroImmunoModulation. 20, 4, p. 223-232 10 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Seizures
Animal Models
Lipopolysaccharides
Inflammation
1 Citation (Scopus)
Brain Concussion
Dizziness
Brain
Equipment and Supplies
Postural Balance

Potential therapeutic effect of curcumin, a natural mTOR inhibitor, in tuberous sclerosis complex

Kuo, C. J., Huang, C. C., Chou, S. Y., Lo, Y. C., Kao, T. J., Huang, N. K., Lin, C., Lin, H. C., Lin, H. C. & Lee, Y. C., Feb 15 2019, In : Phytomedicine. 54, p. 132-139 8 p.

Research output: Contribution to journalArticle

Tuberous Sclerosis
Curcumin
Therapeutic Uses
Memory Disorders
Lipids

Pparα deficiency inhibits the proliferation of neuronal and glial precursors in the zebrafish central nervous system

Hsieh, Y. C., Chiang, M. C., Huang, Y. C., Yeh, T. H., Shih, H. Y., Liu, H. F., Chen, H. Y., Wang, C. P. & Cheng, Y. C., Dec 1 2018, In : Developmental Dynamics. 247, 12, p. 1264-1275 12 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Zebrafish
Neuroglia
Central Nervous System
Brain Neoplasms
1 Citation (Scopus)

Prevalence and clinical characteristics of stroke patients with p.R544C NOTCH3 mutation in Taiwan

Tang, S. C., Chen, Y. R., Chi, N. F., Chen, C. H., Cheng, Y. W., Hsieh, F. I., Hsieh, Y. C., Yeh, H. L., Sung, P. S., Hu, C. J., Chern, C. M., Lin, H. J., Lien, L. M., Peng, G. S., Chiou, H. Y. & Jeng, J. S., Jan 1 2019, In : Annals of Clinical and Translational Neurology. 6, 1, p. 121-128 8 p.

Research output: Contribution to journalArticle

Taiwan
Stroke
Mutation
Cerebral Hemorrhage
CADASIL
7 Citations (Scopus)

Prevalence of intestinal parasitic infections among primary school children in areas devoid of sanitation in northwestern Kingdom of Swaziland, Southern Africa

Fan, C. K., Liao, C. W., Lyu, S. Y., Sukati, H., Ji, D. D., Cho, C. M., Jien, J. Y., Huang, Y. C., Chang, W. S. P., Chiu, W. T., Nara, T., Tsubouchi, A., Huang, Y. H., Tu, C. C., Lan, S. J. & Chao, J. C. J., Mar 2012, In : Pathogens and Global Health. 106, 1, p. 60-62 3 p.

Research output: Contribution to journalArticle

Parasitic Intestinal Diseases
Swaziland
Protozoan Infections
Southern Africa
Parasitic Diseases