The Ph.D. Program for Neural Regenerative Medicine

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output 2000 2019

2018
2 Citations (Scopus)

Pomalidomide ameliorates H2O2-induced oxidative stress injury and cell death in rat primary cortical neuronal cultures by inducing anti-oxidative and anti-apoptosis effects

Tsai, Y. R., Chang, C. F., Lai, J. H., Wu, J. C. C., Chen, Y. H., Kang, S. J., Hoffer, B. J., Tweedie, D., Luo, W., Greig, N. H., Chiang, Y. H. & Chen, K. Y., Oct 19 2018, In : International Journal of Molecular Sciences. 19, 10

Research output: Contribution to journalArticle

Oxidative stress
apoptosis
Cell death
Cell culture
death

Pparα deficiency inhibits the proliferation of neuronal and glial precursors in the zebrafish central nervous system

Hsieh, Y. C., Chiang, M. C., Huang, Y. C., Yeh, T. H., Shih, H. Y., Liu, H. F., Chen, H. Y., Wang, C. P. & Cheng, Y. C., Dec 1 2018, In : Developmental Dynamics. 247, 12, p. 1264-1275 12 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Zebrafish
Neuroglia
Central Nervous System
Brain Neoplasms
2 Citations (Scopus)

Profound deficits in hippocampal synaptic plasticity after traumatic brain injury and seizure is ameliorated by prophylactic levetiracetam

Chen, Y. H., Kuo, T. T., Huang, E. Y. K., Hoffer, B. J., Chou, Y. C., Chiang, Y. H., Ma, H. I. & Miller, J. P., Feb 20 2018, In : Oncotarget. 9, 14, p. 11515-11527 13 p.

Research output: Contribution to journalArticle

etiracetam
Neuronal Plasticity
Seizures
Percussion
Hippocampus
1 Citation (Scopus)

Prototype Deep Brain Stimulation System with Closed-Loop Control Feedback for Modulating Bladder Functions in Traumatic Brain Injured Animals

Jen, E., Lin, C. W., Hsieh, T. H., Chiu, Y. C., Lu, T. C., Chen, S. C., Chen, M. C. & Peng, C. W., Jun 1 2018, In : Journal of Medical and Biological Engineering. 38, 3, p. 337-349 13 p.

Research output: Contribution to journalArticle

Feedback control
Brain
Animals
Feedback
Surface mount technology
5 Citations (Scopus)

Resveratrol inhibits human leiomyoma cell proliferation via crosstalk between integrin αvβ3 and IGF-1R

Ho, Y., SH Yang, Y. C., Chin, Y. T., Chou, S. Y., Chen, Y. R., Shih, Y. J., Whang-Peng, J., Changou, C. A., Liu, H. L., Lin, S. J., Tang, H. Y., Lin, H. Y. & Davis, P. J., Oct 1 2018, In : Food and Chemical Toxicology. 120, p. 346-355 10 p.

Research output: Contribution to journalArticle

resveratrol
integrins
Myoma
Cell proliferation
somatomedins
2 Citations (Scopus)

Role of Nogo Receptor-1 for Recovery of Balance, Cognition, and Emotion after Mild Traumatic Brain Injury in Mice

Lai, J-H., Karlsson, T. E., Wu, J. C-C., Huang, C-Z., Chen, Y-H., Kang, S-J., Brodin, A. T. S., Hoffer, B. J., Olson, L., Chiang, Y-H. & Chen, K-Y., Nov 17 2018, In : Journal of Neurotrauma.

Research output: Contribution to journalArticle

Brain Concussion
Cognition
Emotions
Doxycycline
Aptitude
4 Citations (Scopus)
Glioblastoma
Amyloid
Integrins
Serum
Glioma
2 Citations (Scopus)
Cerebral Hemorrhage
stroke
blood lipids
hemorrhage
Cholesterol
2 Citations (Scopus)
Drug infusion
Infusion Pumps
Glucose Intolerance
Insulin
Glucose

The applications of smart mobile device for detecting balance dysfunction in individuals with down syndrome

Hsieh, T. H., Peng, C. W., Chen, K. Y., Huang, Y. Z., Lin, Y. H., Zhong, W. Z., Liang, J. I., Zhao, J., Cheng, C. Y., Chang, Y. J., Cheng, C. H. & Chuang, Y. F., Feb 1 2018, In : Biomedical Engineering - Applications, Basis and Communications. 30, 1, 1850007.

Research output: Contribution to journalArticle

Mobile Applications
Down Syndrome
Mobile devices
Equipment and Supplies
Nervous System Diseases
5 Citations (Scopus)

The association between BDNF Val66Met polymorphism and emotional symptoms after mild traumatic brain injury

Wang, Y. J., Chen, K. Y., Kuo, L. N., Wang, W. C., Hsu, Y. W., Wong, H. S. C., Lin, C. M., Liao, K. H., Zhang, Y. F., Chiang, Y. H. & Chang, W. C., Jan 22 2018, In : BMC Medical Genetics. 19, 1, 13.

Research output: Contribution to journalArticle

Brain Concussion
Brain-Derived Neurotrophic Factor
Equipment and Supplies
Alleles
Depression
7 Citations (Scopus)
Glucosides
Doxorubicin
antioxidant
Antioxidants
Focal Segmental Glomerulosclerosis

The use of intensity-based Doppler variance method for single vessel response to functional neurovascular activation

Kuo, W. C., Kuo, Y. M., Syu, J. P., Wang, H. L., Lai, C. M., Chen, J. W., Lo, Y. C. & Chen, Y. Y., Jul 1 2018, In : Journal of Biophotonics. 11, 7, e201800017.

Research output: Contribution to journalArticle

vessels
Blood
Chemical activation
Optical tomography
Optical Coherence Tomography
1 Citation (Scopus)

Upregulation of Znf179 acetylation by SAHA protects cells against oxidative stress

Wu, C. C., Lee, P. T., Kao, T. J., Chou, S. Y., Su, R. Y., Lee, Y. C., Yeh, S. H., Liou, J. P., Hsu, T. I., Su, T. P., Chuang, C. K., Chang, W. C. & Chuang, J. Y., Oct 1 2018, In : Redox Biology. 19, p. 74-80 7 p.

Research output: Contribution to journalArticle

Acetylation
Oxidative stress
Zinc Fingers
Zinc
Oxidative Stress
6 Citations (Scopus)

USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy

Wang, Y. C., Wu, Y. S., Hung, C. Y., Wang, S. A., Young, M. J., Hsu, T. I. & Hung, J. J., Dec 1 2018, In : Nature Communications. 9, 1, 3996.

Research output: Contribution to journalArticle

Open Access
Tumor Microenvironment
Macrophages
Tumors
Interleukin-6
tumors
6 Citations (Scopus)

Voluntary physical exercise improves subsequent motor and cognitive impairments in a rat model of parkinson’s disease

Hsueh, S. C., Chen, K. Y., Lai, J. H., Wu, C. C., Yu, Y. W., Luo, Y., Hsieh, T. H. & Chiang, Y. H., Feb 8 2018, In : International Journal of Molecular Sciences. 19, 2, 508.

Research output: Contribution to journalArticle

Parkinson disease
impairment
physical exercise
Oxidopamine
rats
3 Citations (Scopus)

Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology

Lee, Y-C., Huang, W-C., Lin, J-H., Kao, T-J., Lin, H-C., Lee, K-H., Lin, H-C., Shen, C-K. J., Chang, W-C. & Huang, C-C., Nov 8 2018, In : Journal of Biomedical Science. 25, 1, p. 76 1 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Pathology
Amyotrophic Lateral Sclerosis
Frontotemporal Lobar Degeneration
Proteins
2017
9 Citations (Scopus)

(−)-Phenserine inhibits neuronal apoptosis following ischemia/reperfusion injury

Chang, C. F., Lai, J. H., Wu, J. C. C., Greig, N. H., Becker, R. E., Luo, Y., Chen, Y. H., Kang, S. J., Chiang, Y. H. & Chen, K. Y., Dec 15 2017, In : Brain Research. 1677, p. 118-128 11 p.

Research output: Contribution to journalArticle

Reperfusion Injury
Apoptosis
Middle Cerebral Artery Infarction
Acetylcholinesterase
Stroke
3 Citations (Scopus)

1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4 H -indazol-4-one: A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than Morphine

Chao, P. K., Ueng, S. H., Ou, L. C., Yeh, T. K., Chang, W. T., Chang, H. F., Chen, S. C., Tao, P. L., Law, P. Y., Loh, H. H., Cheng, M. F., Chuang, J. Y., Chen, C. T., Shih, C. & Yeh, S. H., May 1 2017, In : Anesthesiology. 126, 5, p. 952-966 15 p.

Research output: Contribution to journalArticle

Opioid Receptors
Morphine
Opioid Analgesics
Charcoal
Surgical Instruments
9 Citations (Scopus)

A polygenic risk score for breast cancer risk in a Taiwanese population

Hsieh, Y. C., Tu, S. H., Su, C. T., Cho, E. C., Wu, C. H., Hsieh, M. C., Lin, S. Y., Liu, Y. R., Hung, C. S. & Chiou, H. Y., May 1 2017, In : Breast Cancer Research and Treatment. 163, 1, p. 131-138 8 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Population
Single Nucleotide Polymorphism
Genome-Wide Association Study
Area Under Curve
3 Citations (Scopus)

A proof-of-principle simulation for closed-loop control based on preexisting experimental thalamic DBS-enhanced instrumental learning

Wang, C. F., Yang, S-H., Lin, S. H., Chen, P. C., Lo, Y. C., Pan, H. C., Lai, H. Y., Liao, L. D., Lin, C. H., Chen, H. Y., Huang, W. C., Huang, W. J. & Chen, Y. Y., May 1 2017, In : Brain Stimulation. 10, 3, p. 672-683 12 p.

Research output: Contribution to journalArticle

Operant Conditioning
Deep Brain Stimulation
Learning
Intralaminar Thalamic Nuclei
Essential Tremor
7 Citations (Scopus)

A rapid and quantitative method to detect human circulating tumor cells in a preclinical animal model

Tu, S. H., Hsieh, Y. C., Huang, L. C., Lin, C. Y., Hsu, K. W., Hsieh, W. S., Chi, W. M. & Lee, C. H., Jun 23 2017, In : BMC Cancer. 17, 1, 440.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Animal Models
Neoplasms
Cell Count
Neoplasm Metastasis
2 Citations (Scopus)

Associations of estradiol levels and genetic polymorphisms of inflammatory genes with the risk of ischemic stroke

Hsieh, Y. C., Hsieh, F. I., Chen, Y. R., Hu, C. J., Jeng, J. S., Tang, S. C., Chi, N. F., Lin, H. J., Lien, L. M., Peng, G. S. & Chiou, H. Y., Mar 28 2017, In : Journal of Biomedical Science. 24, 1, 25.

Research output: Contribution to journalArticle

Genetic Polymorphisms
Polymorphism
Estradiol
Genes
Stroke
10 Citations (Scopus)

Blockade of dengue virus infection and viral cytotoxicity in neuronal cells in vitro and in vivo by targeting endocytic pathways

Ho, M. R., Tsai, T. T., Chen, C. L., Jhan, M. K., Tsai, C. C., Lee, Y. C., Chen, C. H. & Lin, C. F., Dec 1 2017, In : Scientific Reports. 7, 1, 7023.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Clathrin
Vacuolar Proton-Translocating ATPases
Endocytosis
2 Citations (Scopus)

Bortezomib-induced miRNAs direct epigenetic silencing of locus genes and trigger apoptosis in leukemia

Chu, Y. Y., Ko, C. Y., Wang, S. M., Lin, P. I., Wang, H. Y., Lin, W. C., Wu, D. Y., Wang, L. H. & Wang, J. M., Nov 9 2017, In : Cell death & disease. 8, 11, p. e3167

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Protein-delta
Gene Silencing
Yin-Yang
MicroRNAs
Epigenomics
5 Citations (Scopus)
Head Protective Devices
Taiwan
urban area
rural area
Odds Ratio
6 Citations (Scopus)
glycohemoglobin
Glycosylated Hemoglobin A
stroke
retrospective studies
fasting

Correction: Relationship of mechanical impact magnitude to neurologic dysfunction severity in a rat traumatic brain injury model (PLoS ONE (2017) 12:5 (e0178186) DOI: 10.1371/journal.pone.0178186)

Hsieh, T. H., Kang, J. W., Lai, J. H., Huang, Y. Z., Rotenberg, A., Chen, K. Y., Wang, J. Y., Chan, S. Y., Chen, S. C., Chiang, Y. H. & Peng, C. W., Jul 1 2017, In : PLoS One. 12, 7, e0182300.

Research output: Contribution to journalComment/debate

Brain models
Licensure
Neurologic Manifestations
nervous system
Reproduction
3 Citations (Scopus)

Decreased power but preserved bursting features of subthalamic neuronal signals in advanced Parkinson's patients under controlled desflurane inhalation anesthesia

Lin, S. H., Lai, H. Y., Lo, Y. C., Chou, C., Chou, Y. T., Yang, S. H., Sun, I., Chen, B. W., Wang, C. F., Liu, G. T., Jaw, F. S., Chen, S. Y. & Chen, Y. Y., Dec 12 2017, In : Frontiers in Neuroscience. 11, DEC, 701.

Research output: Contribution to journalArticle

Inhalation Anesthesia
Subthalamic Nucleus
Deep Brain Stimulation
General Anesthesia
Parkinson Disease
10 Citations (Scopus)

Dengue virus infection increases microglial cell migration

Jhan, M. K., Tsai, T. T., Chen, C. L., Tsai, C. C., Cheng, Y. L., Lee, Y. C., Ko, C. Y., Lin, Y. S., Chang, C. P., Lin, L. T. & Lin, C. F., Jan 1 2017, In : Scientific Reports. 7, 1, 91.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Cell Movement
Clathrin
Viral RNA
2 Citations (Scopus)

Diagnostic accuracy of standardised qualitative sensory test in the detection of lumbar lateral stenosis involving the L5 nerve root

Lin, J. H., Hsieh, Y. C., Chen, Y. C., Wang, Y., Chen, C. C. & Chiang, Y. H., Dec 1 2017, In : Scientific Reports. 7, 1, 10598.

Research output: Contribution to journalArticle

Pathologic Constriction
Spinal Nerves
Vibration
Diagnostic Errors
ROC Curve
6 Citations (Scopus)

Distinct roles and differential expression levels of Wnt5a mRNA isoforms in colorectal cancer cells

Huang, T. C., Lee, P. T., Wu, M. H., Huang, C. C., Ko, C. Y., Lee, Y. C., Lin, D. Y., Cheng, Y. W. & Lee, K. H., Aug 1 2017, In : PLoS One. 12, 8, e0181034.

Research output: Contribution to journalArticle

RNA Isoforms
colorectal neoplasms
Colorectal Neoplasms
Catenins
Cells
8 Citations (Scopus)

Dopamine release in the nucleus accumbens is altered following traumatic brain injury

Chen, Y. H., Huang, E. Y. K., Kuo, T. T., Hoffer, B. J., Miller, J., Chou, Y. C. & Chiang, Y. H., Apr 21 2017, In : Neuroscience. 348, p. 180-190 11 p.

Research output: Contribution to journalArticle

Nucleus Accumbens
Dopamine
Wounds and Injuries
Reward
Motivation
3 Citations (Scopus)
Vertebroplasty
Compression Fractures
Taiwan
Respiratory Insufficiency
Cohort Studies
3 Citations (Scopus)

Effects of pulsed-radiofrequency neuromodulation on the rat with overactive bladder

Jen, E., Hsieh, T., Lu, T. C., Chen, M. C., Lee, F. J., Lin, C. T., Chen, S-C., Chu, P. Y., Peng, C-W. & Lin, C. W., Sep 7 2017, In : Neurourology and Urodynamics. 36, 7, p. 1734-1741

Research output: Contribution to journalArticle

Overactive Urinary Bladder
Acetic Acid
Electric Stimulation
Urinary Bladder
Pudendal Nerve
7 Citations (Scopus)

EGF-mediated inhibition of ubiquitin-specific peptidase 24 expression has a crucial role in tumorigenesis

Wang, S-A., Wang, Y. C., Chuang, Y. P., Huang, Y. H., Su, W. C., Chang, W. C. & Hung, J. J., May 25 2017, In : Oncogene. 36, 21, p. 2930-2945 16 p.

Research output: Contribution to journalArticle

Open Access
Ubiquitin
Epidermal Growth Factor
Carcinogenesis
Peptide Hydrolases
Securin
8 Citations (Scopus)

Epigenetic regulation of NOTCH1 and NOTCH3 by KMT2A inhibits glioma proliferation

Huang, Y. C., Lin, S. J., Shih, H. Y., Chou, C. H., Chu, H. H., Chiu, C. C., Yuh, C. H., Yeh, T. H. & Cheng, Y. C., 2017, In : Oncotarget. 8, 38, p. 63110-63120 11 p.

Research output: Contribution to journalArticle

Epigenomics
Glioma
Cell Proliferation
Glioblastoma
Brain Neoplasms
1 Citation (Scopus)

Evaluation of band generation process for classification of cerebrospinal fluid in magnetic resonance images

Lee, K. R., Wu, C. C., Chiang, Y. H. & Lin, J., Feb 6 2017, 2016 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2016 - Conference Proceedings. Institute of Electrical and Electronics Engineers Inc., p. 4305-4310 6 p. 7844908

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cerebrospinal fluid
Magnetic Resonance Image
Magnetic resonance
Fluid
Evaluation
11 Citations (Scopus)

Impact of traumatic brain injury on dopaminergic transmission

Chen, Y. H., Huang, E. Y. K., Kuo, T. T., Miller, J., Chiang, Y. H. & Hoffer, B. J., 2017, In : Cell Transplantation. 26, 7, p. 1156-1168 13 p.

Research output: Contribution to journalReview article

Dopamine
Brain
Adjustment Disorders
Oxidative stress
Physiology
6 Citations (Scopus)

Important Roles of Ring Finger Protein 112 in Embryonic Vascular Development and Brain Functions

Tsou, J. H., Yang, Y. C., Pao, P. C., Lin, H. C., Huang, N. K., Lin, S. T., Hsu, K. S., Yeh, C. M., Lee, K. H., Kuo, C. J., Yang, D. M., Lin, J. H., Chang, W. C. & Lee, Y. C., 2017, In : Molecular Neurobiology. p. 1-15 15 p.

Research output: Contribution to journalArticle

Fingers
Embryonic Development
Blood Vessels
Brain
Proteins

Live images of GLUT4 protein trafficking in mouse primary hypothalamic neurons using deconvolution microscopy

Changou, C. A., Chou, S. Y. & Ajoy, R., Dec 7 2017, In : Journal of Visualized Experiments. 2017, 130, e56409.

Research output: Contribution to journalArticle

Glucose Transporter Type 4
Insulin
Deconvolution
Protein Transport
Neurons
2 Citations (Scopus)

Mapping the naloxone binding sites on the mu-opioid receptor using cell-based photocrosslinkers

Ke, Y. Y., Huang, Y. H., Chien, W. C., Loh, H. H., Chuang, J. Y. & Yeh, S. H., Mar 1 2017, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1865, 3, p. 336-343 8 p.

Research output: Contribution to journalArticle

mu Opioid Receptor
Naloxone
Binding Sites
Morphine
Amber
2 Citations (Scopus)

Medical treatment guidelines for acute migraine attacks

Treatment Guideline Subcommittee of Taiwan Headache Society, Jan 1 2017, In : Acta Neurologica Taiwanica. 26, 2, p. 78-96 19 p.

Research output: Contribution to journalArticle

Migraine Disorders
Guidelines
Tryptamines
Anti-Inflammatory Agents
Pharmaceutical Preparations
2 Citations (Scopus)

Medical treatment guidelines for preventive treatment of migraine

Huang, T. C., Lai, T. H., Wang, S. J., Wang, P. J., Wang, Y. F., Lee, L. H., Lin, K. C., Wu, Z. A., Shih, C. S., Hsu, Y. C., Chen, Y. Y., Chen, W. H., Chen, W. T., Chen, P. K., Huang, T. C., Fu, J. L., Yang, C. P., Yeh, T. H., Liao, Y. C., Lai, T. H. & 3 others, Tsai, J. J., Lu, S. R. & Treatment Guideline Subcommittee of Taiwan Headache Society, Jan 1 2017, In : Acta Neurologica Taiwanica. 26, 1, p. 33-35 3 p.

Research output: Contribution to journalArticle

Migraine Disorders
Guidelines
Taiwan
Therapeutics
Anti-Inflammatory Agents
4 Citations (Scopus)
Taiwan
Breast Neoplasms
DNA Mismatch Repair
Single Nucleotide Polymorphism
Luciferases
59 Citations (Scopus)

Netrin1 Produced by Neural Progenitors, Not Floor Plate Cells, Is Required for Axon Guidance in the Spinal Cord

Varadarajan, S. G., Kong, J. H., Phan, K. D., Kao, T. J., Panaitof, S. C., Cardin, J., Eltzschig, H., Kania, A., Novitch, B. G. & Butler, S. J., May 17 2017, In : Neuron. 94, 4, p. 790-799.e3

Research output: Contribution to journalArticle

Axons
Spinal Cord
Chemotactic Factors
Chemotaxis
Growth
2 Citations (Scopus)

Neurovascular function recovery after focal ischemic stroke by enhancing cerebral collateral circulation via peripheral stimulation-mediated interarterial anastomosis

Pan, H-C., Liao, L-D., Lo, Y-C., Chen, J-W., Wang, H-L., Yang, L., Liang, Y-W., Huang, P-Y., Yang, M-H. & Chen, Y-Y., Jul 2017, In : Neurophotonics. 4, 3, p. 035003

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Collateral Circulation
Forelimb
Recovery of Function
Stroke
1 Citation (Scopus)

Nm23-H1-stabilized hnRNPA2/B1 promotes internal ribosomal entry site (IRES)-mediated translation of Sp1 in the lung cancer progression

Hung, C. Y., Wang, Y. C., Chuang, J. Y., Young, M. J., Liaw, H., Chang, W. C. & Hung, J. J., Dec 1 2017, In : Scientific Reports. 7, 1, 9166.

Research output: Contribution to journalArticle

Protein Biosynthesis
Lung Neoplasms
Proteins
Messenger RNA
Protein Stability
8 Citations (Scopus)

PARK14 PLA2G6 mutants are defective in preventing rotenoneinduced mitochondrial dysfunction, ROS generation and activation of mitochondrial apoptotic pathway

Chiu, C. C., Yeh, T. H., Lu, C. S., Huang, Y. C., Cheng, Y. C., Huang, Y. Z., Weng, Y. H., Liu, Y. C., Lai, S. C., Chen, Y. L., Chen, Y. J., Chen, C. L., Chen, H. Y., Lin, Y. W. & Wang, H. L., 2017, In : Oncotarget. 8, 45, p. 79046-79060 15 p.

Research output: Contribution to journalArticle

Phospholipases A2
Rotenone
Parkinson Disease
Mitochondrial Degradation
Mitochondrial Membrane Potential
1 Citation (Scopus)
Brain Concussion
Dizziness
Brain
Equipment and Supplies
Postural Balance