Taipei Medical University

Projects

Projects per year 2002 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2026

• 2 Not started
• 586 Active
• 7151 Finished

Projects per year

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• b - Ministry of Science and Technology

  CXCL6/CXCL1 axis在PDK1訊號路徑介導的放射抗性肝細胞癌之分子機制探討

  Tsai, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 設計與合成芳醯基雜環之抗癌化合物

  Lee, H.

  5/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 評估以慢性病病人用藥經驗理論為基礎之藥病溝通策略：混合方法研究

  Chang, E. H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 慢性肝病在台灣是一個極具挑戰性的臨床議題。肝纖維化的多重病原性是造成病患死亡 率增加的原因，而且肝纖維化往往會發展成肝癌。我們最近利用國民營養調查資料庫 (NAHSIT 2005-2008)分析國人血中鐵營養值標與代謝症候群的相關性.在全人口的分析 中，我們發現校正了血清發炎指標以及飲食的營養指標後, serum ferritin (鐵蛋白質) 高於最大三等分位的族群，得到代謝性症候群的危險對比值超過 1.6 倍. 目前並不清楚 過量的鐵蛋白質為何與代謝症候群的發生率有關。肝臟為重要的儲鐵器官但是臨床研究 也顯示過量的鐵質沉積與肝纖維化及肝癌有極大的相關性。血清中鐵蛋白質為反映體內 儲存鐵的生化質標。但是,發炎因子也會造成血清中鐵蛋白質的異常增加。證據顯示發炎 因子可以調控鐵蛋白質的基因表現量。但是慢性發炎如何造成鐵蛋白質代謝異常(組職 內沉積及釋放)? 血清中的鐵蛋白質又有何生理功能? 隨著國人代謝症候群及脂肪肝發生率的年輕化,這次研究的主題是以老鼠初代星狀肝細 胞來分析鐵蛋白質對內質網壓力機轉與肝纖維化的影響: 相關研究的主要目標為: 1. 釐清鐵蛋白質(serum ferritin)過量是否會造成星狀細胞內質網壓力增加與活化? 2. 何種鐵質(ferric, ferrous, ferritin, Apoferritin)較易增加內質網壓力? 3. 找出何種內質網壓力的轉錄因子 (ATF6,ATF4, XBP1 and CHOP)受到鐵質調控? 4. 分析鐵質誘導的內質網壓力機轉與肝臟纖維化的營響

  Chang, J.

  9/1/12 → 8/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Ferritins 100%
  • Iron 59%
  • Liver 24%
  • Apoferritins 23%
  • Liver Cirrhosis 22%

• 探討芳香烴受體(AhR)改變血管內皮細胞功能之新角色：經由表觀基因或後轉譯修飾(細胞週期蛋白/內皮細胞一氧化氮合成酉每)的調控與白蘆黎醇/史達汀臨床治療及應用(2/3)

  Juan, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of glutamine supplementation on T cell homeostasis and inflammatory response in inflammatory bowel disease

  Yeh, S.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • glutamine 100%
  • inflammatory bowel disease 84%
  • colitis 78%
  • T-lymphocytes 59%
  • ulcerative colitis 57%

• Functional Investigation of Heat Shock Protein in Esophageal Squamous Cell Cancer with Implications in Prognostic Prediction and Therapeutic Targeting

  Tzao, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Heat-Shock Proteins 100%
  • Esophageal Squamous Cell Carcinoma 56%
  • Neoplasms 33%
  • 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin 28%
  • Esophageal Neoplasms 24%

• Using chemical synthetic lethal screening to identify novel compounds that sensitize acute myeloid leukemia with FLT3-ITD mutations to novel small-molecule FLT3 tyrosine kinase inhibitors, ITRI-260 and overcome microenvironment-mediated drug resistan

  Liu, H.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Acute Myeloid Leukemia 100%
  • Mutation 46%
  • Drug Resistance 38%
  • Protein-Tyrosine Kinases 28%
  • midostaurin 17%

• 醫學人文課程之執業場域體驗學習對低年級醫學生醫療專業素養養成之影響

  Tang, K.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Long-Term Impact of Discharge Destinations and Transitional Care Uses on Health and Medical Utilization for High-Risk Discharged Older Adults (2/3)

  Chi, M.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development and Validation of Healthcare Providers Faculty Training for Competence-Base Medical Education: Nursing Preceptor

  Guo, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 台灣醫療機構病人安全文化之國際比較－以美國為例

  Kuo, N.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Cytotoxicity and Application on Drug Resistant Cells of Halide Derivatives of Rutaecarpine

  Lin, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Evodiamine 100%
  • Poison 67%
  • Halide 66%
  • Topoisomerase Inhibitor 49%
  • Antimicrobial Agent 40%

• 從食安風險暴露之角度探討非營養性甜味劑對女性生殖狀況之影響-非營養甜味劑暴露之評估及其對脂肪組織的影響(2/3)

  Chen, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Taiwanese heterosexual women’s and lesbians’ breast health and medical technology applications

  Wang, Y.

  11/1/16 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Assessing Trends and Influencing Factors of Medical Services Utilization and Expenditures and the Likelihood of Employment Status Change among Women with Postpartum Depression—A Ten-Year Retrospective Matched Case-Control Study with National Claims

  Huang, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • medical services 100%
  • expenditures 76%
  • Taiwan 72%
  • utilization 69%
  • incidence 55%

• Adsorption and Oxidation of Acidic Pharmaceuticals on the Surface of Manganese Oxide (II)

  Hu, C.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • manganese 100%
  • oxidation 96%
  • manganese oxide 90%
  • drug 90%
  • oxidant 76%

• Preventive Effect and Mechanism of Adlay Bran Extract on Colorectal Cancer

  Shih, C.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Chemopreventive 100%
  • Antiinflammatory 67%
  • Anti-Inflammatory Agent 45%
  • Nonsteroid Antiinflammatory Agent 40%
  • Microarrays 38%

• Gender Difference in the Complications and Mortality of Hospitalized Patients: Surgery and Anesthesia, Intensive Care Unit, Stroke, and Diabetes (Main Point: V03)

  Liao, C.

  8/1/16 → 10/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Critical Care 100%
  • Stroke 62%
  • Intensive Care Units 37%
  • Taiwan 33%
  • Mortality 22%

• Motor Signature, Falls Risk, and Home-Based Interventions in Older Adults with Mild Cognitive Impairment

  Lin, M.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation the Functional Roles and Molecular Mechanism of Long Non-Coding Rna-Crnde in Autophagy and Oxaliplatin Drug Resistance

  Lee, K.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• New Development Strategy for Novel Multitarget Anticancer Drug Discovery through Artificial Intelligence (Ai) and Machine Learning (Ml) Model

  Huang, H.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 有機金屬催化反應於合成化學和藥物化學之抗癌表觀遺傳學抑制劑研究(2/2)

  Liou, J.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Prevalence, Related Factors and Health Promotion Programs for Sarcopenia among Elderly with Diabetes (2/2)

  Lee, P.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Functional Characterization of Niemann-Pick Type C2 Protein in Hepatocellular Carcinoma

  Liao, Y.

  1/1/13 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hepatocellular Carcinoma 100%
  • Liver Neoplasms 46%
  • Cholesterol 45%
  • Mitogen-Activated Protein Kinase 1 34%
  • Liver 32%

• Functional Investigation of Heat Shock Protein in Esophageal Squamous Cell Cancer with Implications in Prognostic Prediction and Therapeutic Targeting

  Tzao, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Heat-Shock Proteins 100%
  • Esophageal Squamous Cell Carcinoma 56%
  • Neoplasms 33%
  • 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin 28%
  • Esophageal Neoplasms 24%

• Effect of Anesthesia on Lung Cancer Behavior : from Bench to Bedside

  Lin, J. A.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Video-Assisted Thoracic Surgery 100%
  • Inhalation Anesthetics 56%
  • Liquid Biopsy 55%
  • Neoplasms 51%
  • Lung Neoplasms 47%

• Enacting Pregnant Women, Enacting the Foetus Prenatal Screening and Testing in Taiwan

  Shih, L.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • pregnant women 100%
  • Taiwan 75%
  • local politics 43%
  • marriage 27%
  • migrant 26%

• The Molecular Basis, Preventive Efficacy of Angiotension II Receptor Blockade and Quality of Life in Marfan Syndrome

  Chiu, H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Marfan Syndrome 100%
  • Fibrillin-1 35%
  • Losartan 28%
  • Dilatation 19%
  • Quality of Life 15%

• Study the Effect of Dietary Tryptophan Supplementation Strategies in Parkinson’S Disease Progression and Tryptophan Metabolism with Plag6 Knockin Mice

  Huang, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

  • tryptophan 100%
  • Parkinson disease 95%
  • disease progression 45%
  • metabolism 34%
  • long term effects 34%

• 常用中藥與抗生素之交互作用評估

  Lee, C.

  7/1/18 → 2/28/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 結合光交聯水膠及生長因子作為生物墨水以開發富含血管網路的三維列印之肝臟組織(2/3)

  Lin, C.

  1/1/22 → 12/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討檜木醇治療缺血再灌注之肝損傷的新策略(3/3)

  Lu, W.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Novel Tetracyclic and Heterocyclic Dual Topoisomerases Inhibitors as Anticancer Agents( I )

  Huang, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Topoisomerase Inhibitor 100%
  • Antineoplastic Agent 79%
  • Molecule 51%
  • Compound Mobility 45%
  • Anthraquinone 32%

• The Emerging Role That Splicing Factor Plays in the Adipose Development

  Lin, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • brown adipose tissue 100%
  • adipose tissue 84%
  • insulin receptors 78%
  • adipogenesis 75%
  • energy 49%

• Motor Vehicle Injuries and Screening Tools of Unsafe Driving in Older Drivers

  Lin, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Screening 100%
  • Emergency rooms 57%
  • Motorcycles 43%
  • Public health 42%
  • Medical problems 39%

• 核糖核甘酸還原酉每抑制劑在人類乳突瘤病毒感染之非小細胞肺癌治療效果評估

  Hsu, N.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Applying ADDIE Model in Developing Educational Program about Depressive Symptoms among Older Residents for Nurses in Long-Term Care Facilities

  Chuang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Depression 100%
  • Long-Term Care 92%
  • Nurses 82%
  • Sample Size 25%
  • Smartphone 23%

• 以CRISPR/Cas9基因編輯平台發展MYC/BCL2/BCL6作為人類B細胞淋巴癌標靶精準治療模式

  Chen, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 真實世界數據應用於風險評估設定醫療照護模式以提昇住院照護品質研究-方法建立與導入實施(1/2)

  Chen, T.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Synthesis and Antihyperglycemic Evaluation of Isosteviol Derivatives

  Lin, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Drug 100%
  • Antidiabetic Agent 77%
  • Inositol 74%
  • Diester 69%
  • Bioactivity 68%

• Research on Charactertics and Mechanism of Adaptive Metamaterials by Functionally Graded 4d Printing

  Shen, Y.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 嗜伊紅性白血球陽離子蛋白衍生之細胞穿透胜肽對於調節過敏性發炎之研究- 促進STAT-6反義RNA之運送與表現(2/3)

  Lee, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討夜交藤萃取物合併Amoxicillin對於胃潰瘍的治療機制

  Lee, C.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以胜肽為基礎之細胞激素結合誘餌療法於治療敗血症之療效及其調控發炎、氧化、凋亡、自嗜與發炎小體之作用探討(1/3)

  Huang, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Micro-Scale Surface-Enhanced Raman Spectroscopy in Real-Time Single Living Cell Diagnostics (II)

  Peng, P.

  10/1/14 → 9/30/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • chemotaxis 100%
  • cell 33%
  • Raman spectroscopy 30%
  • bottom-up approach 23%
  • locomotion 21%

• Effects of Glutamine Supplementation on T Cell Homeostasis and Inflammatory Response in Inflammatory Bowel Disease

  Yeh, S.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • glutamine 100%
  • inflammatory bowel disease 84%
  • colitis 78%
  • T-lymphocytes 59%
  • ulcerative colitis 57%

• Uncovering the Specific Interactions between DNA Mimic Proteins and Their Target DNA Binding Proteins by Structure-Based Studies

  Wang, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • DNA 100%
  • Uracil-DNA Glycosidase 61%
  • Proteins 58%
  • Neisseria 55%
  • DNA-Binding Proteins 44%

• Drug Discovery and Pharmacological Investigation of Novel Selective Hdac Inhibitors as Anticancer Drugs

  Pan, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Systemic Analysis on Dynamic Mechanism of Actin Cytoskeleton Organization Regulated Physiological Changes Caused by Physical Stimuli in Mesenchymal Stem Cells

  Ho, J.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Actins 100%
  • Mesenchymal Stem Cells 72%
  • Proteins 24%
  • Polymerization 22%
  • Microfilament Proteins 19%