Taipei Medical University

Projects

Projects per year 2002 2013 2014 2015 2016 2017 2018 2019 2020 2021 2026

• 2 Not started
• 288 Active
• 6863 Finished

Projects per year

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• b - Ministry of Science and Technology

  價創計畫：使用人工智慧來建構智慧醫院及健康照護生態圈-從疾病到健康與樂活

  Chen, R.

  5/1/18 → 4/30/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 針對IL-33/ST2訊息路徑調控鈣平衡、內質網壓力與粒線體功能作為心房與肺靜脈心律不整活性與心房顫動致病機轉及治療策略探討(2/3)

  Chen, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 雙極症患者單核球和巨噬細胞活化與血管粥狀化的關聯性: 頸動脈超音波的個案對照研究(1/3)

  Tsai, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 自體免疫心肌炎引起心室心律不整及鈣離子調控失衡、粒線體異常與NLRP3/MIF發炎體訊息路徑活化之致病機轉及治療策略探討(1/3)

  Chen, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討膠質母細胞瘤外泌體中Btk/PD-L1/PD-L2 訊號途徑在腫瘤免疫所扮演的致病角色及其精準治療應用

  Lin, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• RAB3C對大腸直腸癌之抗藥性與腫瘤免疫反應影響之探討(2/3)

  Chen, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• An Action Research Approach to Clinical Skills Education Development : Using Reflective Writing to Promote the Transformation of Students’ Skill Acquisition toward the Way of Better-Best-Practice

  Lin, W., Chen, C. & Wu, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • action research 100%
  • instruction 69%
  • medicine 54%
  • development project 36%
  • reflexivity 35%

• 探查Pearson氏症候群的基因診斷與在患者衍生細胞上的施行清除粒線體DNA缺失的可行性

  Kao, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 雙極症患者視網膜血管和頸動脈粥狀化、視神經層厚度和腦體積之關聯及影響因素

  Tsai, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of miR-21 in Regulating TET I-Hydroxymethylcytosine and Chemotherapeutic Response in Colorectal Cancer (I)

  Yang, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Colorectal Neoplasms 100%
  • 5-hydroxymethylcytosine 84%
  • APC Genes 58%
  • DNA Methylation 55%
  • Adenomatous Polyposis Coli 51%

• Decellularized Lymph Node Scaffold Vaccine Seeded with Dendritic Cells for Inducing Specific Antitumor Immunity

  Liu, D.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Dendritic Cells 100%
  • Lymph Nodes 61%
  • Immunity 30%
  • Neoplasms 28%
  • Neoplasm Antigens 26%

• Antibody-Mediated Immune Suppression of Fetal and Neonatal Alloimmune Thrombocytopenia ( FNAIT)

  Burnouf, T. P. R.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • thrombocytopenia 100%
  • immunoglobulin G 34%
  • antigens 26%
  • antibodies 23%
  • hemorrhage 14%

• 設計及合成香豆素衍生物作為單羧酸轉運蛋白 MCTs抑制劑之活性研究

  Lin, M.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Impacts of the Electron Transfer Flavoprotein Dehydrogenase Mutation on in Vitro Human Skeletal Muscle Plasticity

  Kao, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Toxicity of Chitosan Nanowaste in Freshwater Fishes: Establishment of Toxicity Assessment Platform for Nanomaterials

  Cheng, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 具遠外線與微波脈波測量的穿載式醫療模組 (重點主題:A3)(2/3)

  Chen, C.

  5/1/18 → 4/30/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Translational Genomic Approaches in Endometriosis

  Tzeng, C.

  8/1/12 → 10/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • endometrium 100%
  • microRNA 90%
  • stem cells 61%
  • cell adhesion molecules 54%
  • metastasis 35%

• Effects of Different Oils Combined with Lycium Barbarum Extract on Chemical-Induced Liver Inflammation and Fibrosis in Rats

  Chao, J. C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Olive Oil 100%
  • Stellate Crystal 89%
  • Signal Transduction 47%
  • Antifibrotic 37%
  • Apoptotic 25%

• Self, Consciousness, and Neurophilosophy

  Lane, T. J.

  1/1/15 → 6/30/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Molecular Model 100%
  • Neurophilosophy 96%
  • Applied Ethics 80%
  • Self-consciousness 68%
  • Philosophy of Science 60%

• Effects of Fish Oil on Alcoholic Liver Disease in Rats Based on Pathological Mechanisms

  Yang, S.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • liver diseases 100%
  • alcohol abuse 83%
  • fish oils 81%
  • liver function 46%
  • rats 39%

• The Molecular Biological Mechanism of Fish Oil on Preventing Alcoholic Liver Diseases: The Hepatoprotective Effects of EPA and DHA Based on Lipid Metabolism, Autophagy and Inflammatory Responses

  Yang, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • fish oils 100%
  • ethanol 40%
  • rats 36%
  • lipid metabolism 34%
  • liver diseases 30%

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • pyrimidin-2-one beta-ribofuranoside 100%
  • Autophagy 29%
  • Hypoxia 16%
  • Autophagic Cell Death 13%
  • Colorectal Neoplasms 12%

• Dissected the Role of Thrombomodulin in the Clinical Diagnostic and Therapeutic Impacts for Breast Cancer and the Regulation Mechanisms(3/3)

  Hung, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Thrombomodulin 100%
  • Breast Neoplasms 90%
  • Therapeutics 20%
  • Neoplasms 12%
  • Steroid Receptors 11%

• Fucoidan/Urokinase Assembled Magnetic Nanoparticles for the Detection of Thrombosis and Targeted Thrombolytic Therapy

  Mi, F.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Targeting a Novel Neurotrophic Signaling Ngf-Chrm4 in Drug-Resistant Neuroendocrine Prostate Cancer

  Chen, W.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 標靶B型肝炎誘發之肝癌腫瘤生成與Sorafenib抗藥性之微環境：聚焦發炎激素與癌幹細胞特性之轉譯精準醫學研究與臨床意義-探討微環境發炎細胞激素與基因後生調節於B型肝炎病毒誘導之肝癌表現多能性幹細胞基因OCT4與Sorafenib抗藥性之調控機制與其臨床意義(3/3)

  Huang, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 芳香烴受體於眼科疾病之治療潛力機制探討-芳香烴受體於藍光誘發視網膜病變之治療潛力機制探討(1/3)

  Cheng, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 外科系醫學(一)學門規劃研究推動計畫

  Wu, C.

  1/1/12 → 12/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Publication of Journal of Biomedical Science

  Chang, W.

  1/1/11 → 12/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Scholarly Communication 100%
  • Taiwan 99%
  • Publications 83%
  • Biological Science Disciplines 62%
  • Information Dissemination 59%

• The Role of Amyloid-Beta in the Late-Onset Post-Stroke Vascular Cognitive Impairment( II )

  Hu, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of High-Throughput Sequencing Approaches in Immunogenomic Research : Diversity and Clonal Selection in the Human T-Cell Repertoire for Colonrectal Cancers(3/4)

  Chang, W.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Tgfbi Signaling as a Mechanism of Hormonal Therapy Resistance and Prostate Cancer Bone Metastasis

  Chen, W.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Prostatic Neoplasms 100%
  • Castration 57%
  • Androgen Receptors 55%
  • Androgens 33%
  • Androgen Receptor Antagonists 22%

• Application of Regioselective Substitution on 1,4-Benzoquinone Derivatives to Provide Potent Anticancer Agents

  Liou, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • 1,4-benzoquinone 100%
  • Wittig Olefination 54%
  • Intramolecular Cyclization 40%
  • Nucleophilic Substitution 38%
  • Regioselectivity 35%

• Effects of Different Sources of n-3 Fatty Acids on Bone Loss, Body Fat and Inflammatory Markers in Osteoporotic Condition with Diabetes

  Chiu, W. & Fong, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Fatty Acid 100%
  • Fat 66%
  • Ligand 24%
  • Deoxypyridinoline 20%
  • Marker 19%

• The Oncogenic Role and Targeted Therapeutic Potential of Alpha 9 Nicotinic Acetylcholine Receptors on Breast Cancers: Emphasizing in Pre-Clinical Assessment of Biphasic Antibody Nano-Drugs in Xenografts( I )

  Chang, J.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 三陰性乳癌周邊微環境之研究平台建立：以玻尿酸合成酉每Ⅲ抑癌作用為例(1/3)

  Ho, Y.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• TNKS / PI31訊息傳遞路徑在TDP-43相關神經病變中調控蛋白?體之機制(1/3)

  Huang, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Metformin抑制TRPA1與P2X3受器所引發的呼吸反射及過度敏感之機制探討

  Lin, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Design and Characterization of Multifunctional Self-Assembling Lecithin/Amphiphilic Polymers Mixed Micellar Delivery Systems

  Sheu, M.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Micelle 100%
  • Lecithin 36%
  • Drug 29%
  • Pharmaceutical 29%
  • Amphotericin B 21%

• A Mind-Body Approach to Study Irritable Bowel Syndrome: Role of Psychological Distress, Effectiveness and Mechanisms of Mindfulness Training(1/3)

  Tsai, P., Chang, C. & Chen, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mindfulness 100%
  • Depression 82%
  • Anxiety 79%
  • Self-Help Groups 49%
  • Urbanization 35%

• Role of Normoxic Expression of Hypoxia Inducible Factor 1-Α and Endoplasmic Reticulum Stress Associated Protein Grp-78 in the Modulation of Drug-And Radioresistance Acquisition of Human Hepatoma Cell Lines

  Chiou, J.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hypoxia-Inducible Factor 1 100%
  • 1-phenyl-3,3-dimethyltriazene 55%
  • Reticulum 33%
  • Research Design 31%
  • Paclitaxel 26%

• Bone-Marrow-Derived Mesenchymal Stem Cells in Prostate Cancer-Induced Bone Remodeling

  Hsieh, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Adipogenic 100%
  • Osteogenic 37%

• Molecular Ivestigation of the Electron Transfer Flavoprotein Dehydrogenase Mutation Induced Mitochondrial Dysfunction and Metabolic Defects

  Kao, S. & Hsu, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • acyl-CoA dehydrogenase 100%
  • flavoproteins 97%
  • electron transfer 79%
  • droplets 39%
  • myoblasts 31%

• Effects of Essential Oils on Smooth Muscle Contraction in Rat Uterus (Gm07)

  Hsia, S.

  8/1/12 → 12/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • uterine contraction 100%
  • essential oils 70%
  • prostaglandins 51%
  • muscle contraction 51%
  • smooth muscle 41%

• Molecular Mechanisms of Alpha 9-Nicotinic Acetylcholine Receptor (Alpha 9-nAChRs)-Mediated Trastuzumab (Herceptin R) Drug Resistance in Breast Cancer Cells

  Ho, Y.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Breast Neoplasms 100%
  • Trastuzumab 93%
  • MicroRNAs 66%
  • CP 14 54%
  • Antineoplastic Agents 50%

• Risk Assessment and Predictive Model of Potentially Ineffective Care of Patients in Intensive Care Units - Analysis Using Taiwan National Health Insurance Research Database

  Chen, T.

  8/1/16 → 10/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Intensive Care Units 100%
  • Preexisting Condition Coverage 48%
  • National Health Programs 42%
  • Health Expenditures 40%
  • Taiwan 39%

• The Carotid Atherosclerosis and Cardiac Function Measured by Ultrasonography in Bipolar Mania and Their Relevent Clinical Factors

  Tsai, S.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Acceptance and Commitment Therapy (Act) on Internalized Stigma and Low Self-Esteem among Patients with Schizophrenia

  Chung, M.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Determined the Role and the Mechanims of GRP94 in Mediating the Progression and Therapeutic Responses of HCC

  Huang, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • glucose-regulated proteins 100%
  • Heat-Shock Proteins 15%
  • Neoplasms 11%
  • Neoplasm Metastasis 8%
  • Preclinical Drug Evaluations 8%

• Co-Transplantation of Encapsulated Xenogeneic Islets in the Functionalized Zwitterionic Hydrogels with Pre-Conditioned Mscs-Derived Exosomes for the Treatment of Type I Diabetes

  Yang, K.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Exosomes 100%
  • Mesenchymal Stem Cells 53%
  • Hydrogels 36%
  • Islets of Langerhans Transplantation 32%
  • Type 1 Diabetes Mellitus 30%