Projects per year
- 5,600 - 5,650 out of 7,140 results
Search results
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The Role and Molecular Mechanism of PPARα in Acute Kidney Injury---Focus on the Protective Effect in Renal Tubular Cell
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Dementia Care and Quality Improvement
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Studies on the Teaching Model to Foster Mindfulness through Arts Performance in Medicine Students
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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臺蒙(MN)國合計畫-台灣及蒙古之洋蔥及蔥屬蔬菜對骨質疏鬆症的影響(2/3)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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A Clinical Correlation Study of DNA Methyltransferases Alterations in Breast Cancer and Evaluation of DNA Methyltransferases as a Therapeutic Target in Cell and Animal Models
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Relationships of One-Carbon Cycle Pathways with Psychopathology and Metabolic Abnormalities in Patients with Schizophrenia and Potential Intervention Strategy with 5-Methyltetrahydrofolate and Vitamin B12
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關,曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能,包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義,這也促使我們想要釐清E1A抑制癌症的機制。因此,我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣,並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示,E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中,GRP78所扮演的生物功能及其調控的機轉。為了達到此目的,我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標: 目標一:探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二:研究E1A抑制GRP78表現之分子機轉 目標三:於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四:探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外,藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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開發微米中空纖維陣列膜作為血液過濾器之研究
6/1/14 → 7/31/15
Project: C - Project of Alliance › p - Taipei Medical University Hospital
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Investigation of the Intrinsic Molecular Mechanisms of ETV6 That Contribute to Suppression of Metastasis and Sensitivity of Chemotherapy in Prostate Cancer
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Studies on the Role of ORMDL3 in Thrombin-Induced IL-8/CXCL8 Expression and Airway Inflammation
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Explore of Toll-Like Receptors Associated miRNA Expression in Ischemic Stroke Patients (II)
Wu, C.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Chemo-Sensitizer Conjugated Carbon Nanotubes as a Novel Cancer Therapeutical Delivery System
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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The Imapct of Oxidative Stress on the Pathogenesis of COPD---An Ivestigation into Its Relationship with Abnormal Inflammation, Dna Instability, Epigenetics and Cell Metabolism
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Electrophysiological and Molecular Insights into the Cardiac Regulations of ZFHX3 Gene---Implication in the Pathophysiology of Atrial Fibrillation
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects of Resveratol on Proliferation of Leiomyoma: in Vitro and in Vivo Study (A09)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Evaluating the Effect of Migration Stimulating Factor on Wound Healing Behavior at the Cellular Level Using Nano-Biomedical Technologies
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects of Different Sources of n-3 Fatty Acids on Bone Loss, Body Fat and Inflammatory Markers in Osteoporotic Condition with Diabetes
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Emerging Mechanisms of Omega-3 Fatty Acids in Depression---The Effects of EPA and DHA on Chronic Stress, Neurogenesis and Neuroinflammation
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Oncolytic Measles Virus for the Treatment of Breast Adenocarcinoma
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Plant Metabolomics---1. Agave sisalana; 2. Anoectochilus formosanus; 3. Phalaenopsis spp.)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Analysis the Role of Satellite Cell during Denervation Induced Muscular Atrophy and a Trail of Transplantation of Adipocyte Derived Myogenic Stem Cells
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Exploration of RBM4-Regulated Splicing Events in Differentiating Adipocytes by Using Next-Generation Sequencing
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Developing New Diagnostic and Therapeutic Strategies for Lung Cancer with ROS1, RET and NTRK1 Mutations in Patients without EGFR, KRAS and ALK Mutations
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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The Roles of Novel CCCH Zinc Finger Genes on the Regulation of Cell Proliferation and Inflammation
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Investigation of Glioblastoma Cell-Secreted microRNA Signatures and Their Functional Effects on Tumor Angiogenesis
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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山藥儲藏性蛋白質功能性月生月太之延緩衰老功能評估與機制探討(2/3)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Synaptic Plasticity by Nogo-1 Receptor Overexpression and Exendin-4 Administration on Behavioral and Electrophysiological Recovery after Mild Traumatic Brain Injury (III)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Exploration and Development of Infection Control Model of Long-Term Care Facilities.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Efficacy Studies of Tn-Directed Therapeutic Antibody and Immunotoxin in Syngeneic Mouse Tumor Models
Hwang, J.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Role of miR-21 in Regulating TET I-Hydroxymethylcytosine and Chemotherapeutic Response in Colorectal Cancer (I)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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油症患者健康照護服務條例之辦法擬訂工作計畫
3/4/15 → 7/31/15
Project: A - Government Institution › c - Ministry of Health and Welfare
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Natural Product Hybrid and Ortho-Biaryl N-Hydroxycinnamide as Leads for Anticancer Agent Development
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects of Different Oils Combined with Lycium Barbarum Extract on Chemical-Induced Liver Inflammation and Fibrosis in Rats
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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氧化還原作用調控蛋白質去磷酸酉每羰基化和去羰基化反應對動脈血管內膜增生之影響(1/2)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Dissected the Role of Glucosed-Regulated Portein 78 in the Progression, Metastasis and Therapy of Colorectal Cancer
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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探討小泛素蛋白Sentrin-specific protease 2 參與轉型生長因子-beta訊息傳遞的作用機制(2/2)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Study the Therapeutic Role of Niemann-Pick Type C2 Protein in Liver Cancer
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Haplo-Insufficiency of TSGs on Chromosome 2 for Paclitaxel-Resistant Phenotype of OCCA Cells
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Molecular Mechanisms of PARP-1 in Regulating NLRP3 Inflammasome Activation
Lin, W.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Mixed Pharmceuticals Adsorption, Oxidation and Catalytic Chlorination by Metal Oxides
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Study of the Mechanism of HPV Involved Tumorigenesis through Wnt Signaling Pathway Related microRNA Regulation
Cheng, Y. & Lee, H.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Evaluation of the Mechanism of Post-Traumatic Immunosuppression---The Role of TLR4 Trafficking and microRNA
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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榖胱甘月太硫轉移酉每參與乳癌致癌之分子機制探討(3/3)
Wu, C.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Role of ER Stress in Evodiamine-Induced Apoptosis and G2/M Arrest of Human Colorectal Carcinoma Cells
Chen, Y.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Association between Lipid, Glucose Related Genes and Prognosis of Intra- and Extra-Cranial Stenosis in Stroke Patients
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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肺纖維化之轉譯研究-組蛋白去乙醯酉每2的SUMO化修飾貢獻於慢性阻塞性氣喘的結締組織生長因子表現與肺部纖維化反應(2/3)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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The Association Study of Genetic Polymorphisms of Toll-Like Receptors on Ischemic Stroke (II)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Role of HBX and IL-6 in Regulating SENP1/Stemness Properties of HBV-Related HCC under Hypoxia and Its Clinical Implication
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Vaccine Liability and Vaccine Injury Compensation Program’s Influences on the Production and Use of Vaccines
1/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology