• No. 250 Wu-Xing Street

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Research Output 1985 2020

2020

A cost-effectiveness analysis of trastuzumab-containing treatment sequences for HER-2 positive metastatic breast cancer patients in Taiwan

Diaby, V., Alqhtani, H., van Boemmel-Wegmann, S., Wang, C. Y., Ali, A. A., Balkrishnan, R., Ko, Y., Palacio, S. & de Lima Lopes, G., Feb 1 2020, In : Breast. 49, p. 141-148 8 p.

Research output: Contribution to journalArticle

Open Access

An assessment of the psychometric properties of the Chinese version of the Gout Impact Scale

Pao, C. H. & Ko, Y., Jan 2 2020, In : Current Medical Research and Opinion. 36, 1, p. 17-21 5 p.

Research output: Contribution to journalArticle

Aza-PBHA, a potent histone deacetylase inhibitor, inhibits human gastric-cancer cell migration via PKCα-mediated AHR-HDAC interactions

Tsai, C. H., Li, C. H., Liao, P. L., Chang, Y. W., Cheng, Y. W. & Kang, J. J., Feb 2020, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1867, 2, 118564.

Research output: Contribution to journalArticle

Comparison of the predictive outcomes for anti-tuberculosis drug-induced hepatotoxicity by different machine learning techniques

Lai, N. H., Shen, W. C., Lee, C. N., Chang, J. C., Hsu, M. C., Kuo, L. N., Yu, M. C. & Chen, H. Y., May 2020, In : Computer Methods and Programs in Biomedicine. 188, 105307.

Research output: Contribution to journalArticle

Dramatically enhanced mechanical properties of diamond-like carbon films on polymer substrate for flexible display devices via argon plasma pretreatment

Lee, J. A., Lin, C. R., Pan, P. C., Liu, C. W. & Sun, A. Y. T., Jan 15 2020, In : Chemical Physics. 529, 110551.

Research output: Contribution to journalArticle

Intercalating pyrene with polypeptide as a novel self-assembly nano-carrier for colon cancer suppression in vitro and in vivo

Lo, P. Y., Lee, G. Y., Zheng, J. H., Huang, J. H., Cho, E. C. & Lee, K. C., Apr 1 2020, In : Materials Science and Engineering C. 109, 110593.

Research output: Contribution to journalArticle

1 Citation (Scopus)

N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression

Mehndiratta, S., Lin, M. H., Wu, Y. W., Chen, C. H., Wu, T. Y., Chuang, K. H., Chao, M. W., Chen, Y. Y., Pan, S. L., Chen, M. C. & Liou, J. P., Jan 1 2020, In : European Journal of Medicinal Chemistry. 185, p. 111725 111725.

Research output: Contribution to journalArticle

Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment

Kaur, N., Fang, Y. C., Lee, H. Y., Singh, A., Nepali, K., Lin, M. H., Yeh, T. K., Lai, M. J., Chan, L., Tu, Y. K., Banerjee, S., Hu, C. J. & Liou, J. P., Feb 1 2020, In : European Journal of Medicinal Chemistry. 187, 111915.

Research output: Contribution to journalArticle

Steering the antitumor drug discovery campaign towards structurally diverse indolines

Thakur, A., Singh, A., Kaur, N., Ojha, R. & Nepali, K., Jan 2020, In : Bioorganic Chemistry. 94, 103436.

Research output: Contribution to journalReview article

2019
5 Citations (Scopus)

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

Benzamides
Histone Deacetylases
Tubulin
Heterografts
Inhibitory Concentration 50
1 Citation (Scopus)

Alteration of mesenchymal stem cells polarity by laminar shear stimulation promoting β-catenin nuclear localization

Chen, W-T., Hsu, W-T., Yen, M-H., Changou, C. A., Han, C-L., Chen, Y-J., Cheng, J-Y., Chang, T-H., Lee, O. K-S. & Ho, J. H-C., Jan 1 2019, In : Biomaterials. 190-191, p. 1-10 10 p.

Research output: Contribution to journalArticle

Catenins
Cell Polarity
Stem cells
Mesenchymal Stromal Cells
Shear stress
Growth Inhibitors
Amides
Prostatic Neoplasms
Cells
Lead compounds
Social Welfare
Taiwan
Pharmacists
Pharmaceutical Services
Community Pharmacy Services

A novel preventive mechanism of gentamicin-induced nephrotoxicity by atorvastatin

Lee, M. C., Cheng, K. J., Chen, S. M., Li, Y. C., Imai, K., Lee, C. M. & Lee, J. A., Nov 1 2019, In : Biomedical Chromatography. 33, 11, p. e4639 e4639.

Research output: Contribution to journalArticle

Gentamicins
Cathepsins
Metabolism
Proteomics
Macrophage Migration-Inhibitory Factors
3 Citations (Scopus)

Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivo

Hsieh, Y. L., Tu, H. J., Pan, S. L., Liou, J. P. & Yang, C. R., Jun 1 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 6, p. 992-1003 12 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Histone Deacetylase Inhibitors
Breast Neoplasms
Histone Deacetylases
Acetylation
4 Citations (Scopus)

Applications of cyclic peptide nanotubes (cPNTs)

Hsieh, W. H. & Liaw, J., Jan 2019, (Accepted/In press) In : Journal of Food and Drug Analysis. 27, 1

Research output: Contribution to journalArticle

Peptide Nanotubes
nanotubes
cyclic peptides
Cyclic Peptides
drugs
2 Citations (Scopus)

Association between Anticholinergic Medication Use and Risk of Dementia among Patients with Parkinson's Disease

Sheu, J. J., Tsai, M. T., Erickson, S. R. & Wu, C. H., Jan 1 2019, In : Pharmacotherapy. 39, 8, p. 798-808 11 p.

Research output: Contribution to journalArticle

Cholinergic Antagonists
Parkinson Disease
Dementia
Taiwan
Confidence Intervals

Association of endothelin genetic variants and hospitalized infection complications in end-stage renal disease (ESRD) patients

Kao, C. C., Cheng, S. Y., Wang, Y. J., Chien, S. C., Hsu, Y. W., Wu, M. Y., Lu, H. F., Nam, S., Sun, T., Wu, M. S. & Chang, W. C., Jun 5 2019, In : BMC Nephrology. 20, 1, p. 203 203.

Research output: Contribution to journalArticle

Open Access
Endothelins
Chronic Kidney Failure
Bacteremia
Infection
Single Nucleotide Polymorphism

Association of Metformin Use With End-Stage Renal Disease in Patients With Type 2 Diabetes Mellitus: A Nationwide Cohort Study Under the Pay-for-Performance Program

Lee, M. C., Lee, C. H., Chang, L. Y., Chang, C. H., Zhang, J. F., Lee, M. R., Wang, J. Y. & Chen, S. M., Jan 1 2019, In : Journal of Clinical Pharmacology.

Research output: Contribution to journalArticle

Incentive Reimbursement
Metformin
Type 2 Diabetes Mellitus
Chronic Kidney Failure
Cohort Studies
1 Citation (Scopus)

Cancers in Taiwan: Practical insight from epidemiology, treatments, biomarkers, and cost

Kuo, C. N., Liao, Y. M., Kuo, L. N., Tsai, H. J., Chang, W. C. & Yen, Y., Jan 1 2019, (Accepted/In press) In : Journal of the Formosan Medical Association.

Research output: Contribution to journalReview article

Open Access
Taiwan
Health Care Costs
Epidemiology
Biomarkers
Therapeutic Uses
4 Citations (Scopus)

Carboxylated carbon nanomaterials in cell cycle and apoptotic cell death regulation

Lee, K. C., Lo, P. Y., Lee, G. Y., Zheng, J. H. & Cho, E. C., Apr 20 2019, In : Journal of Biotechnology. 296, p. 14-21 8 p.

Research output: Contribution to journalArticle

Nanostructures
Cell death
Nanostructured materials
Cell Cycle
Cell Death

Characterization of T-Cell Receptor Repertoire in Patients with Rheumatoid Arthritis Receiving Biologic Therapies

Chang, C. M., Hsu, Y. W., Wong, H. S. C., Wei, J. C. C., Liu, X., Liao, H. T. & Chang, W. C., Jan 1 2019, In : Disease Markers. 2019, 1 p.

Research output: Contribution to journalArticle

Open Access

Characterizing tyrosinase modulators from the roots of angelica keiskei using tyrosinase inhibition assay and UPLC-MS/MS as the combinatorial novel approach

Lee, J. H., Mei, H. C., Kuo, I. C., Lee, T. H., Chen, Y. H. & Lee, C. K., Sep 10 2019, In : Molecules. 24, 18, 3297.

Research output: Contribution to journalArticle

Open Access
Angelica
Monophenol Monooxygenase
Modulators
modulators
Assays
3 Citations (Scopus)

Chloramphenicol induces autophagy and inhibits the hypoxia inducible factor-1 alpha pathway in non-small cell lung cancer cells

Hsu, H. L., Liao, P. L., Cheng, Y. W., Huang, S. H., Wu, C. H., Li, C. H. & Kang, J. J., Jan 1 2019, In : International Journal of Molecular Sciences. 20, 1, 157.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
hypoxia
Autophagy
Chloramphenicol
Non-Small Cell Lung Carcinoma
1 Citation (Scopus)

Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status

Chao, M. W., Chang, L. H., Tu, H. J., Chang, C. D., Lai, M. J., Chen, Y. Y., Liou, J. P., Teng, C. M. & Pan, S. L., May 29 2019, In : Clinical Epigenetics. 11, 1, 85.

Research output: Contribution to journalArticle

Open Access
Histone Deacetylase Inhibitors
Mitogen-Activated Protein Kinase Kinases
Pancreatic Neoplasms
Epidermal Growth Factor Receptor
Heterografts

Constructing a bilingual website with validated database for Herb and Western medicine interactions using Ginseng, Ginkgo and Dong Quai as examples

Wu, C. S., Chen, Y. H., Chen, C. L., Chien, S. K., Syifa, N., Hung, Y. C., Cheng, K. J., Hu, S. C., Lo, P. T., Lin, S. Y. & Wu, T. H., Nov 27 2019, In : BMC Complementary and Alternative Medicine. 19, 1, 335.

Research output: Contribution to journalArticle

Open Access

Correction: Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and akt activation in non-small cell lung cancer cells (Oncotarget (2017) 8 (28342–28358) DOI: 10.18632/oncotarget.16058)

Tsai, M. H., Liu, J. F., Chiang, Y. C., Hu, S. C. S., Hsu, L. F., Lin, Y. C., Lin, Z. C., Lee, H. C., Chen, M. C., Huang, C. L. & Lee, C. W., May 1 2019, In : Oncotarget. 10, 36, 1 p.

Research output: Contribution to journalArticle

Open Access
Taiwan
Non-Small Cell Lung Carcinoma
Rehabilitation
Apoptosis
artocarpin flavonoid

Costs and Length of Stay of Hospitalizations due to Diabetes-Related Complications

Cheng, S. W., Wang, C. Y. & Ko, Y., Jan 1 2019, In : Journal of Diabetes Research. 2019, 2363292.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Development of Decellularized Cornea by Organic Acid Treatment for Corneal Regeneration

Lin, H. J., Wang, T. J., Li, T. W., Chang, Y. Y., Sheu, M. T., Huang, Y. Y. & Liu, D. Z., Apr 1 2019, In : Tissue Engineering - Part A. 25, 7-8, p. 652-662 11 p.

Research output: Contribution to journalArticle

Organic acids
Scaffolds
Cornea
Regeneration
Swine
1 Citation (Scopus)

Divaricoside Exerts Antitumor Effects, in Part, by Modulating Mcl-1 in Human Oral Squamous Cell Carcinoma Cells

Weng, J. R., Bai, L. Y., Chiu, S. J., Chiu, C. F., Lin, W. Y., Hu, J. L. & Shieh, T. M., Jan 1 2019, In : Computational and Structural Biotechnology Journal. 17, p. 151-159 9 p.

Research output: Contribution to journalArticle

Glycosides
Squamous Cell Carcinoma
Cardiac Glycosides
Cells
Cell death

Does long-term use of antidiabetic drugs changes cancer risk?

Liu, Y. C., Nguyen, P. A., Humayun, A., Chien, S. C., Yang, H. C., Asdary, R. N., Syed-Abdul, S., Hsu, M. H., Moldovan, M., Yen, Y., Li, Y. C., Jian, W. S. & Iqbal, U., Oct 1 2019, In : Medicine (United States). 98, 40, p. e17461 e17461.

Research output: Contribution to journalArticle

Open Access
Hypoglycemic Agents
pioglitazone
Neoplasms
Odds Ratio
Confidence Intervals

Down-regulation of aryl hydrocarbon receptor intensifies carcinogen-induced retinal lesion via SOCS3-STAT3 signaling

Tsai, C. H., Lee, Y., Li, C. H., Cheng, Y. W. & Kang, J. J., Jan 1 2019, (Accepted/In press) In : Cell Biology and Toxicology.

Research output: Contribution to journalArticle

Doxorubicin conjugated AuNP/biopolymer composites facilitate cell cycle regulation and exhibit superior tumor suppression potential in KRAS mutant colorectal cancer

Hung, W. H., Zheng, J. H., Lee, K. C. & Cho, E. C., Dec 20 2019, In : Journal of Biotechnology. 306, p. 149-158 10 p.

Research output: Contribution to journalArticle

Efficacy of azatyrosine-phenylbutyric hydroxamides, a histone deacetylase inhibitor, on chemotherapy-induced gastrointestinal mucositis

Liao, P. L., Huang, S. H., Hung, C. H., Huang, W. K., Tsai, C. H., Kang, J. J., Wang, H. P. & Cheng, Y. W., Jan 1 2019, In : International Journal of Molecular Sciences. 20, 2, 249.

Research output: Contribution to journalArticle

monocytes
interleukins
Mucositis
Histone Deacetylase Inhibitors
Chemotherapy
1 Citation (Scopus)

Elucidation of the Effects of Si-Wu Tang on Menstrual Disorder Patterns through Activation of Aromatase and Antioxidation

Huang, G. C., Tsai, Y. Z., Lee, C. J., Chang, H. Y. & Wang, C. C., Mar 6 2019, In : Evidence-based Complementary and Alternative Medicine. 2019, p. 4761651 8 p., 4761651.

Research output: Contribution to journalArticle

Open Access
Rehmannia
Aromatase
ferulic acid
Polyphenols
Estradiol
1 Citation (Scopus)

Expression of AHI1 Rescues Amyloidogenic Pathology in Alzheimer’s Disease Model Cells

Ting, L. L., Lu, H. T., Yen, S. F., Ngo, T. H., Tu, F. Y., Tsai, I. S., Tsai, Y. H., Chang, F. Y., Li, X. J., Li, S., Lee, C. K., Kao, S. H., Kuo, Y. M. & Lin, Y. F., Nov 1 2019, In : Molecular Neurobiology. 56, 11, p. 7572-7582 11 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Alzheimer Disease
Pathology
Amyloid
Protein C
1 Citation (Scopus)

Functional effects of let-7g expression in colon cancer metastasis

Chang, C. M., Wong, H. S. C., Huang, C. Y., Hsu, W. L., Maio, Z. F., Chiu, S. J., Tsai, Y. T., Chen, B. K., Wan, Y. J. Y., Wang, J. Y. & Chang, W. C., Apr 1 2019, In : Cancers. 11, 4, 489.

Research output: Contribution to journalArticle

Open Access
Colonic Neoplasms
Colorectal Neoplasms
Neoplasm Metastasis
Neoplasms
Atlases

Gallate-induced nanoparticle uptake by tumor cells: Structure-activity relationships

Cheng, M. C., Lu, Y. C., Wu, J. & Ma, Y. H., Jul 1 2019, In : Colloids and Surfaces B: Biointerfaces. 179, p. 28-36 9 p.

Research output: Contribution to journalArticle

gallates
Structure-Activity Relationship
Nanoparticles
Tumors
tumors
2 Citations (Scopus)

Ganglioside Hp-s1 Analogue Inhibits Amyloidogenic Toxicity in Alzheimer's Disease Model Cells

Tsai, Y. F., Yang, D. J., Ngo, T. H., Shih, C. H., Wu, Y. F., Lee, C. K., Phraekanjanavichid, V., Yen, S. F., Kao, S. H., Lee, H. M., Huang, V. S., Shieh, J. C. C. & Lin, Y. F., Jan 16 2019, In : ACS Chemical Neuroscience. 10, 1, p. 528-536 9 p.

Research output: Contribution to journalArticle

Gangliosides
Amyloid beta-Protein Precursor
Toxicity
Alzheimer Disease
Cells

Genetic loci determining total immunoglobulin E levels from birth through adulthood

Yao, T. C., Chung, R. H., Lin, C. Y., Tsai, P. C., Chang, W. C., Yeh, K. W., Tsai, M. H., Liao, S. L., Hua, M. C., Lai, S. H., Chen, L. C., Chang, S. W., Yu, Y. W., Hsu, J. Y., Chang, S. C., Cheng, W. C., Hu, D., Hong, X., Burchard, E. G., Wang, X. & 3 others, Tzeng, J. Y., Tsai, H. J. & Huang, J. L., Mar 1 2019, In : Allergy: European Journal of Allergy and Clinical Immunology. 74, 3, p. 621-625 5 p.

Research output: Contribution to journalLetter

Genetic Loci
Immunoglobulin E
Parturition

Genomic interrogation of familial short stature contributes to the discovery of the pathophysiological mechanisms and pharmaceutical drug repositioning

Wong, H. S. C., Lin, Y. J., Lu, H. F., Liao, W. L., Chen, C. H., Wu, J. Y., Chang, W. C. & Tsai, F. J., Nov 7 2019, In : Journal of Biomedical Science. 26, 1, 91.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Glycemia Lowering Effect of an Aqueous Extract of Hedychium coronarium Leaves in Diabetic Rodent Models

Tse, L. S., Liao, P. L., Tsai, C. H., Li, C. H., Liao, J. W., Kang, J. J. & Cheng, Y. W., Mar 14 2019, In : Nutrients. 11, 3

Research output: Contribution to journalArticle

Open Access
Hedychium coronarium
Zingiberaceae
Type 2 Diabetes Mellitus
blood glucose
Rodentia
1 Citation (Scopus)

HDAC8 inhibitor WK2-16 therapeutically targets lipopolysaccharide-induced mouse model of neuroinflammation and microglial activation

Lin, F. L., Yen, J. L., Kuo, Y. C., Kang, J. J., Cheng, Y. W., Huang, W. J. & Hsiao, G., Jan 2 2019, In : International Journal of Molecular Sciences. 20, 2, p. 410 410.

Research output: Contribution to journalArticle

Neuroglia
inhibitors
mice
Lipopolysaccharides
Chemical activation
1 Citation (Scopus)

High accuracy differentiating autoimmune pancreatitis from pancreatic ductal adenocarcinoma by immunoglobulin G glycosylation

Shih, H. C., Chang, M. C., Chen, C. H., Tsai, I. L., Wang, S. Y., Kuo, Y. P., Chen, C. H. & Chang, Y. T., Jan 3 2019, In : Clinical Proteomics. 16, 1

Research output: Contribution to journalArticle

Open Access
Glycosylation
Pancreatitis
Adenocarcinoma
Immunoglobulin G
Regression Analysis

HSPB1 rs2070804 polymorphism is associated with the depth of primary tumor

Hung, C. S., Huang, C. Y., Hsu, Y. W., Makondi, P. T., Chang, W. C., Chang, Y. J., Wang, J. Y. & Wei, P. L., Jan 1 2019, In : Journal of Cellular Biochemistry.

Research output: Contribution to journalArticle

Polymorphism
Tumors
Colorectal Neoplasms
Single Nucleotide Polymorphism
Neoplasms
1 Citation (Scopus)

Hypersensitivity and cardiovascular risks related to allopurinol and febuxostat therapy in Asians: A population-based cohort study and meta-analysis

Chen, C-H., Chen, C-B., Chang, C. J., Lin, Y. J., Wang, C-W., Chi, C-C., Lu, C-W., Chen, W-T., Pan, R-Y., Su, S-C., Hsu, L-A., Chang, Y-C., Yu, K-H., Wu, Y-J. J., Lin, K-M., Hung, S-I., Chen, S-M. & Chung, W-H., Jan 28 2019, In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Allopurinol
Meta-Analysis
Hypersensitivity
Cohort Studies
Population

Impact of metformin use among tuberculosis close contacts with diabetes mellitus in a nationwide cohort study

Lee, M. C., Lee, C. H., Lee, M. R., Wang, J. Y. & Chen, S. M., Nov 6 2019, In : BMC Infectious Diseases. 19, 1, 936.

Research output: Contribution to journalArticle

Open Access

Improved Dried Blood Spot-Based Metabolomics Analysis by a Postcolumn Infused-Internal Standard Assisted Liquid Chromatography-Electrospray Ionization Mass Spectrometry Method

Chepyala, D., Kuo, H. C., Su, K. Y., Liao, H. W., Wang, S. Y., Chepyala, S. R., Chang, L. C. & Kuo, C. H., Jan 1 2019, In : Analytical Chemistry.

Research output: Contribution to journalArticle

Electrospray ionization
Liquid chromatography
Mass spectrometry
Blood
Metabolites