School of Nutrition and Health Sciences

  • No. 250 Wu-Xing Street

    11031 Taipei

Projects 2010 2020

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b - Ministry of Science and Technology

慢性肝病在台灣是一個極具挑戰性的臨床議題。肝纖維化的多重病原性是造成病患死亡 率增加的原因,而且肝纖維化往往會發展成肝癌。我們最近利用國民營養調查資料庫 (NAHSIT 2005-2008)分析國人血中鐵營養值標與代謝症候群的相關性.在全人口的分析 中,我們發現校正了血清發炎指標以及飲食的營養指標後, serum ferritin (鐵蛋白質) 高於最大三等分位的族群,得到代謝性症候群的危險對比值超過 1.6 倍. 目前並不清楚 過量的鐵蛋白質為何與代謝症候群的發生率有關。肝臟為重要的儲鐵器官但是臨床研究 也顯示過量的鐵質沉積與肝纖維化及肝癌有極大的相關性。血清中鐵蛋白質為反映體內 儲存鐵的生化質標。但是,發炎因子也會造成血清中鐵蛋白質的異常增加。證據顯示發炎 因子可以調控鐵蛋白質的基因表現量。但是慢性發炎如何造成鐵蛋白質代謝異常(組職 內沉積及釋放)? 血清中的鐵蛋白質又有何生理功能? 隨著國人代謝症候群及脂肪肝發生率的年輕化,這次研究的主題是以老鼠初代星狀肝細 胞來分析鐵蛋白質對內質網壓力機轉與肝纖維化的影響: 相關研究的主要目標為: 1. 釐清鐵蛋白質(serum ferritin)過量是否會造成星狀細胞內質網壓力增加與活化? 2. 何種鐵質(ferric, ferrous, ferritin, Apoferritin)較易增加內質網壓力? 3. 找出何種內質網壓力的轉錄因子 (ATF6,ATF4, XBP1 and CHOP)受到鐵質調控? 4. 分析鐵質誘導的內質網壓力機轉與肝臟纖維化的營響

Chang, J.

9/1/128/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Effect of Different Dietary Fats on Gut Microbiota, Fatty Liver and Insulin Resistance in Postmenopausal Condition

Chiu, W.

8/1/167/31/17

Project: A - Government Institutionb - Ministry of Science and Technology

105大專生計畫獎-李信昌

Li, S.

8/1/167/31/17

Project: A - Government Institutionb - Ministry of Science and Technology

Potential of Capsaicin against Advanced Glycation Endproducts Formation

Wu, C.

12/1/1211/30/13

Project: A - Government Institutionb - Ministry of Science and Technology

The Study of Antidepressive and Cognition Improvement Property of N-3 Fatty Acids on Metabolic Syndroms

Huang, S.

8/1/147/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of Saturated Fatty Acids from Animals and Vegetables on Alcoholic Liver Disease in Rats Based on Phathological Mechanism.

Yang, S.

8/1/147/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of Melatonin on Lipid Metabolism

Chien, Y.

8/1/157/31/16

Project: A - Government Institutionb - Ministry of Science and Technology

Explore of Toll-Like Receptors Associated miRNA Expression in Ischemic Stroke Patients (II)

Wu, C.

8/1/147/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

The Improvements of Glutamine, Epidermal Growth Factor and Synbiotics on Alcoholic Liver Diseases by the Intestinal Health

Yang, S.

8/1/107/31/11

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of fish oil on alcoholic liver disease in rats based on pathological mechanisms

Yang, S.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Factors Related to Infant Feeding Practice and Weight Change in Postpartum Women

Chen, Y. C.

8/1/107/31/11

Project: A - Government Institutionb - Ministry of Science and Technology

The Effect of Blood Sugar Regulation and Molecular Mechanism by White Potato Extract

Li, S.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The Study of Antidepressive and Cognition Improvement Property of N-3 Fatty Acids on Metabolic Syndroms

Huang, S.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

鐵質誘發巨噬細胞活化與遷移對胰島素耐受性的影響

Chang, J.

8/1/147/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

甜蜜的戰爭-提升家長對兒童食品包裝上糖資訊的認知與運用(1/2)

Chen, Y. C.

8/1/187/1/19

Project: A - Government Institutionb - Ministry of Science and Technology

Potential of Capsaicin against Advanced Glycation Endproducts Formation

Wu, C.

12/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

本研究擬探討高度糖化終產物及其前驅物甲基乙二醛誘發腎臟與內皮功能損傷之負 面效應,並釐清該損傷機轉是否與活化發炎體有關;此外,另探討白藜蘆醇之介入是否對 於上述損傷具有保護作用。第一部分實驗以高度糖化終產物接受器抑制劑釐清腎臟中高度 糖化終產物接受器的表現是否和發炎體路徑的活化有關,此外評估不同種高度糖化終產物 對於小鼠腎功能之影響。第二部分實驗則以高度糖化終產物接受器抑制劑證實抑制受器和 高度糖化中產物之交互作用是否可達到減少自由基產生進而抑制發炎體的活化以減緩發 炎反應所造成的腎損傷。第三部實驗分則觀察白藜蘆醇對於以高度糖化終產物前驅物MG 誘發腎損傷之影響並釐清白藜蘆醇是否可透過影響發炎體的活化達到延緩腎臟受損的作 用。研究預期長期高度糖化終產物和其前驅物‐甲基乙二醇的投與會使高度糖化終產堆積 在腎臟,也可能經由與其接受器結合進入細胞中活化發炎體路徑使腎臟發炎,使腎臟和內 皮功能損傷。因此減少暴露於高度糖化終產物的環境下或是抑制其接受器的作用皆可抑制 發炎體的活化達到延緩腎損傷的作用,且白藜蘆醇的介入對於上述損傷可能具有保護作用。

Chen, J.

8/1/167/31/17

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of Fish Oil on Alcoholic Liver Disease in Rats Based on Pathological Mechanisms

Yang, S.

8/1/117/31/12

Project: A - Government Institutionb - Ministry of Science and Technology

高度醣化終產物對子宮肌瘤細胞及幹細胞生長之調控機制所扮演的角色:體內及體外試驗(2/3)

Hsia, S.

8/1/187/1/19

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of Essential Oils on Smooth Muscle Contraction in Rat Uterus (Gm07)

Hsia, S.

8/1/1212/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Ffects of Different Sources of n-3 Fatty Acids on Bone Loss, Body Fat and Inflammatory Markers in Osteoporotic Condition with Diabetes

Chiu, W.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

麩醯胺對小鼠後肢缺血再灌流所引致發炎反應和組織損傷之影響(3/3)

Yeh, S.

8/1/167/31/17

Project: A - Government Institutionb - Ministry of Science and Technology

酮體代謝與粒線體功能及生合成之相互影響

Hsieh, R.

8/1/187/1/19

Project: A - Government Institutionb - Ministry of Science and Technology

枸杞多醣體與藻藍素對酒精或藥物誘發胃潰瘍修復作用之影響(2/3)

Chao, J. C.

8/1/177/31/18

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of Different Oils Combined with Lycium Barbarum Extract on Chemical-Induced Liver Inflammation and Fibrosis in Rats

Chao, J. C.

8/1/147/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

n-3多元不飽和脂肪酸對宿主腸道菌相之影響—以憂鬱症為例(1/3)

Huang, S.

8/1/177/31/18

Project: A - Government Institutionb - Ministry of Science and Technology

Inhibitory Effect and Mechanism of Bioactivated Rice on Colorectal Carcinogenesis

Shih, C.

8/1/147/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

臺蒙(MN)國合計畫-台灣及蒙古之洋蔥及蔥屬蔬菜對骨質疏鬆症的影響(1/3)

Chen, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of Indole Derivatives from Vegetable on Lipid Metabolism and Adipogenesis – Involvement of the Ah Receptor?

Chen, Y.

8/1/117/31/12

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of Onion and Allium Vegetables Cultivated in Taiwan and Mongolia on Osteoporosis

Chen, Y.

8/1/157/31/16

Project: A - Government Institutionb - Ministry of Science and Technology

Preventive Effect and Mechanism of Adlay Bran Extract on Colorectal Cancer

Shih, C.

8/1/107/31/11

Project: A - Government Institutionb - Ministry of Science and Technology

Study on the Inhibitory Effect of Lactic Acid Bacteria and Germinated Brown Rice on Colorectal Carcinogenesis

Shih, C., Li, S. & Chen, C.

8/1/157/31/16

Project: A - Government Institutionb - Ministry of Science and Technology

探討不同高油脂飲食合併運動訓練對停經後腸道菌相、非酒精性肝臟疾病及胰島素阻抗之影響

Chiu, W.

8/1/177/31/18

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of Antrodia cinnamomea Extract on Fat Accumulation and Energy Expenditure

Chen, J.

8/1/157/31/16

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of Nutrients Supplementation on Damaged Mitochondria and Their Biogenesis and Turnover

Hsieh, R.

8/1/147/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

Effects of Glutamine on the Inflammatory Response and Tissue Injury in a Hindlimb Ischemic Reperfusion Mice Model

Yeh, S.

8/1/157/31/16

Project: A - Government Institutionb - Ministry of Science and Technology

Renoprotective Mechanisms of Soy Protein in Rats with Diabetic Nephropathy

Chen, J.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Reflex Pelvic Floor Muscle Activities in Women with Urinary Incontinence

Yang, J., Yang, S. & Huang, W.

8/1/117/31/12

Project: A - Government Institutionb - Ministry of Science and Technology

Lay Health Knowledge Research:Example of Infants and Children Dietary Supplement

Chen, Y. C.

8/1/117/31/12

Project: A - Government Institutionb - Ministry of Science and Technology

Explore of Toll-Like Receptors Associated Mirna Expression in Ischemic Stroke Patients (I)

Wu, C.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Infant Feeding Information in the Internet and How the Information Influences the Infant Feeding Behavior

Chen, Y. C.

8/1/157/31/16

Project: A - Government Institutionb - Ministry of Science and Technology

探討飲食中油脂組成和褪黑激素或番茄對停經後大鼠與肥胖婦女脂質代謝與體脂蓄積的影響

Chien, Y.

8/1/187/1/19

Project: A - Government Institutionb - Ministry of Science and Technology

107大專生計畫獎-施純光

Shih, C.

8/1/187/31/19

Project: A - Government Institutionb - Ministry of Science and Technology