School of Medicine

Projects

Projects per year 2010 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2026

• 3 Not started
• 202 Active
• 2322 Finished

Projects per year

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• b - Ministry of Science and Technology

  長散在核元件-1甲基化及DNA甲基化標記5-甲基胞嘧啶與5-甲基-2'-脫氧胞?濃度及尿液總砷濃度與慢性腎臟病的相關性

  Hsueh, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 甲狀腺荷爾蒙調控腸上皮細胞屏障與通透性的角色探討-針對甲狀腺影響腸道作用之路徑研究

  Lin, J.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以酵母beta-葡聚醣作為裝載天然抗氧化化合物與酵素之可食用載體及其控制釋放性質

  Mi, F.

  7/1/22 → 2/28/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effects of the APOE4 Allele on Cerebral Structural and Functional Connectivity---A Diffusion Tensor Imaging and Resting-State MRI Study

  Chen, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Apolipoprotein E4 100%
  • Alleles 83%
  • Brain 39%
  • Short-Term Memory 31%
  • Magnetic Resonance Imaging 26%

• Dissected the Role of Glucose-Regulated Protein 94 (GRP94),The Clinically Therapeutic Implication and Drug Development in Colon Cancer

  Wei, P. & Chang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • glucose-regulated proteins 100%
  • Colonic Neoplasms 43%
  • Colorectal Neoplasms 38%
  • Neoplasms 23%
  • Neoplasm Metastasis 19%

• Gene Promoter Dna Methylations and Their Relationships with Endophenotypes in Patients with Schizophrenia

  Chen, C. & Lu, M.

  8/1/11 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Schizophrenia 100%
  • DNA Methylation 71%
  • Endophenotypes 57%
  • Catechol O-Methyltransferase 49%
  • Methylation 39%

• The Protective Role of Hmg-Coa Reductase Inhibitor，Statins，In Postoperative Complications and Survival of Critically Ill Subjects

  Chen, T.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 三維仿肺呼吸功能實驗室晶片之研發以應用於空污誘發哮喘過敏與肺癌免疫治療研究(2/2)

  Lee, K.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• TIGIT 在調節免疫拮抗點抑制劑抗藥性的角色(1/3)

  Feng, P.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Overcoming Chemo-Resistance in Glioma-Bearing Rats by Using Sequential and Biodegradable Multidrug-Loaded Nanofibrous Membranes(2/2)

  Tseng, Y.

  8/1/18 → 10/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Nanofibers 100%
  • Carmustine 85%
  • Temozolomide 63%
  • Glioblastoma 50%
  • Membranes 30%

• Study of Prevention, Control, Genotyping and Risk Factors of Intestinal Parasitic Infections and Head Lice in Schoolchildren in Cambodia(2/3)

  Liao, C.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立探討膜蛋白折疊的研究平台(2/3)

  Chang, Y.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 病態性肥胖病人之最適化麻醉研究–多重臨床隨機分派試驗

  Tai, Y.

  7/1/20 → 6/30/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of novel genetic mutations for antibiotic resistance, intracellular upregulated Salmonella genes within host cells, and the mechanisms of yqiC-induced host innate immunity for combating Salmonella infection (3/3)

  Fang, S.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Salmonella 100%
  • antibiotic resistance 37%
  • ciprofloxacin 34%
  • point mutation 33%
  • genes 26%

• Degradation of Nitrogen-Containing PPCPs: Kinetic Study, Application, and Balancing the Toxicity of N-DBP and Intermediates through Bioassay

  Chang, E.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • PPCP 100%
  • chlorination 35%
  • ozonation 26%
  • nitrogen 24%
  • byproduct 21%

• Differential Machinery of Pluripotency Regulation in Stem Cells in Embryonic Stage and Somatic Cancers and Its Clinical Implications in Human Diseases---Crosstalk among Niche Growth Factor/Cytokine Signaling, Extracellular Matrix, and Epigenetic Netw (I)

  Huang, Y.

  10/1/14 → 9/30/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Testicular Germ Cell Tumor 100%
  • Embryonic Stem Cells 77%
  • Epigenomics 75%
  • Seminoma 73%
  • Germ Cells 71%

• The Role of ADAM 17 in Hypoxia-Induced CTGF Expression and Pulmonary Fibrosis (III)

  Chen, B.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • ADAM17 Protein 100%
  • Connective Tissue Growth Factor 83%
  • Hypoxia 49%
  • Small Interfering RNA 38%
  • Fibrosis 17%

• Development of a New Drug as a Translational Medical Study to Improve the Obesity and Obesity-Induced Diabetes Nephropathy Syndrome

  Lin, H.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 抑制HIF-1α蛋白質促使線粒體運鐵蛋白功能恢復以改善棕櫚酸酯誘導的胰島素抗性

  Kuo, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigating a Novel Cancer Stem Cell Biomarker Podocalyxin-Like Protein 1 Promotes Epithelial-Mesenchymal Transition and Cancer Stemness in Breast Cancer Cells

  Lin, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • podocalyxin 100%
  • Neoplastic Stem Cells 43%
  • Epithelial-Mesenchymal Transition 26%
  • Proteins 24%
  • Breast Neoplasms 22%

• The Study of Therapeutic Effects for Stroke with Phenserine, an Amyloid Precursor Protein Inhibitor, in Rodent Focal Cerebral Ischemia Model

  Chang, C. & Chiang, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • phenserine 100%
  • Stroke 75%
  • Amyloid beta-Protein Precursor 49%
  • Stem Cells 31%
  • pifithrin 27%

• A Wearable Device Evaluation for Medication Management in Patients Taking Sleep Medicine via Cloud Platform Development( I )

  Li, Y., Jian, W. & Lee, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Sleep 100%
  • Wearable technology 35%
  • Health 28%
  • Education 19%
  • Oximeters 11%

• 乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標： 目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二：研究E1A抑制GRP78表現之分子機轉 目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。

  Wang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • glucose-regulated proteins 100%
  • Neoplasm Metastasis 39%
  • Neoplasms 36%
  • Breast Neoplasms 25%
  • Psychological Inhibition 19%

• Characterization of Thalamocortical Dysrhythmia in Mild Traumatic Brain Injury Using Simultaneous Mri and Eeg Measurements and Pre-Clinical N-Acetylcysteine Treatment Response

  Chen, C., Liu, H., Tseng, S., Lane, T. J., Lu, C., Chiang, Y. & Tsai, P.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Acetylcysteine 44%
  • Post-Concussion Syndrome 17%
  • Neuroimaging 15%
  • Electroencephalography 14%
  • Atrophy 9%

• Association of Peroxisome Proliferator-Activated Receptors, PPAR-Mediated Genes and Ischemic Stroke

  Chiou, H. & Hu, C.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Stroke 100%
  • Peroxisome Proliferator-Activated Receptors 99%
  • Genes 33%
  • Oxidized LDL Receptors 30%
  • Coenzyme A Ligases 27%

• The Severity Model of Brain Damage: Examining the Blood-Brain Early Injurious and Protective Biomarker Panels That Relate to the Susceptibility and Tolerance Responses of Hypoxic Ischemia( I )

  Huang, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Psychophysiological Effects of Lactobacillus Plantarum Ps128 in Patients with Major Depressive Disorder: a Pilot Study of 8-Week Open Trial

  Chen, C.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Lactobacillus plantarum 100%
  • Probiotics 77%
  • Gastrointestinal Microbiome 71%
  • Inflammation 53%
  • Permeability 46%

• 探討纖連蛋白誘導牙齦上皮細胞間質轉化現象中α5β1整合素調節SHP2的角色

  Lin, C.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Evolution of Active Intracranial Atherosclerotic Plaques after Stenting - an Observation Using Mr High Resolution Vessel Wall Imaging

  Chen, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Atherosclerotic Plaques 100%
  • Arteries 71%
  • Endothelial Cells 70%
  • Antioxidants 35%
  • Anti-Inflammatory Agents 35%

• Activation of Adenosine A3 Receptors Suppresses Airway Hypersensitivity: Role of Pulmonary C-Fiber Afferents

  Lin, Y.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Adenosine A3 Receptor Agonists 100%
  • Adenosine A3 Receptors 54%
  • Unmyelinated Nerve Fibers 50%
  • Hypersensitivity 46%
  • Lung 36%

• Sub-Project 1: Mechanisms and Effects of Paired Associative Nerve Stimulation in Spinal Cord Injured Animal Models( I )

  Peng, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 台灣家族特有肌聯蛋白單?酸位點變異導致肌失養症之病因學研究 (II)

  Kuo, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Novel Roles of Aldose Reductase (AR) in Collagen GPVI- and Thrombin PAR4-Mediated Platelet Activation and Apoptosis: Regulatory Machinery of Arf-AR Signaling in Anucleate Cells (II)

  Sheu, J.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Aldehyde Reductase 100%
  • Platelet Activation 36%
  • Blood Platelets 28%
  • epalrestat 21%
  • convulxin 21%

• Telekaryophagy，一種在肝臟和乳腺中新發現的全核消除程序：探索其在基因組穩定性和生理病理學中的作用(1/3)

  Chao, H.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study the Role of the Endoplasmic Reticulum Stress Related Proteins, Glycoprotein 96(Gp96), in Liver Cancer Progression and Metastasis and the Clinically Therapeutic Implication

  Huang, M.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glycoproteins 100%
  • Heat-Shock Proteins 36%
  • Endoplasmic Reticulum Stress 26%
  • Liver Neoplasms 23%
  • Neoplasm Metastasis 21%

• Dose Effect of Extended-Release Metformin on Metabolic Parameters and Neurocognitive Function Treated by Clozapine or Olanzapine in Patients with Schizophrenia: a Randomized, Double-Blinded, Placebo-Controlled Trial

  Lu, M.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Metformin 100%
  • Olanzapine 32%
  • Clozapine 31%
  • Schizophrenia 27%
  • Placebos 22%

• Taipei Medical University Speciality Equipment Service Plan

  Lin, S.

  12/1/18 → 12/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Psychophysiological Effects of Lactobacillus Plantarum Ps128 in Patients with Major Depressive Disorder and High Level of Inflammation：A Pilot Study of 8-Week Open Trail

  Chen, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Lactobacillus plantarum 100%
  • Gastrointestinal Microbiome 89%
  • Inflammation 84%
  • Probiotics 77%
  • Permeability 62%

• The Alteration of Inflammatory Reflex and Its Association with Psychotropic Drugs in Bipolar Disorder from Acute Mania to Full Remission

  Tsai, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Bipolar Disorder 100%
  • Reflex 82%
  • Cholinergic Agents 32%
  • Psychological Power 21%
  • Antipsychotic Agents 21%

• A Toxicological Assessment of Air Pollution in the Vicinity of a Petrochemical Complex

  Chuang, H. & Lee, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Particulate Matter 100%
  • Taiwan 54%
  • Toxicology 44%
  • Risk Assessment 38%
  • Methionine 19%

• The Effects of Metabolic Abnormalities on Cognitive Function in Schizophrenic Patients

  Lu, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Activating Transcription Factor 3 in the Protective Effect of Resveratrol in Cardiomyocytes

  Liu, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Resveratrol 100%
  • Activating Transcription Factor 3 81%
  • Doxorubicin 63%
  • Cardiac Myocytes 47%
  • Activating Transcription Factors 25%

• Service for Sharing Precious Instruments of Taipei Medical University

  Lin, C.

  1/1/14 → 12/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigate the New Therapeutic Strategy of Hinokitiol in Hepatic Ischemia/Reperfusion Injury( I )

  Chen, R.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討具調節STAT訊息之真菌成分在視網膜穆勒及小神經膠細胞作用機制及其改善青光眼誘發神經性退化之療效(1/3)

  Hsiao, G.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 樺木酸可作為IRE1/XBP1/Herp路徑抑制劑以阻斷膠質母細胞瘤的增殖和存活(1/3)

  Lo, W.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Sleep and Memory Consilidation in Alzheimer Disease

  Hu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Sleep 100%
  • Memory Consolidation 87%
  • Alzheimer Disease 59%
  • Memory 31%
  • REM Sleep 28%

• Investigating of Transcranial Direct Current Stimulation and Robot-Assisted Gait Training Effects in Subjects with Stroke (II)

  Lai, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Transcranial Direct Current Stimulation 100%
  • Gait 55%
  • Stroke 46%
  • Leg 15%
  • Aphasia 11%

• Statin Inhibits Pressured-Induced Rat Renal Tubular Cell Apoptosis and Tubulointerstitial Fibrosis

  Chen, T. & Chen, C.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors 100%
  • Peroxisome Proliferator-Activated Receptors 49%
  • Pressure 46%
  • Kidney 44%
  • Nephrosis 29%

• Developing Smart Voice-Control Interfaces and Establishing Smart Living and Work Environments: Based on the Unmet Needs of the Spinal Quadriplegics(Focusing Topic: A6)( II )

  Chen, S.

  1/1/18 → 12/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology