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b - Ministry of Science and Technology
The integrated theraptic effect of the major components of Psidium guajava L. aqueous extracts (PE) (gallic acid, quercetin, EGCG, and rutin) combining with medical trials and control diets on the chronic kidney disease
8/1/11 → 7/31/12
Project: A - Government Institution › b - Ministry of Science and Technology
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In Vivo and in Vitro Studies of Progesterone-Induced Anti-Angiogenesis
Lee, W.
8/1/11 → 7/31/12
Project: A - Government Institution › b - Ministry of Science and Technology
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Relationship between Lumbar Vertebral Perfusion and Fat Marrow Content in Normal Subjects, Osteoporosis and Bone Metastases Using DCE-MRI and Fat-Water Separation
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Environment-Sensitive Chitosan Nanomicelles for Ph-Jump Activation, Oxygen Evolution and Anticancer Drug Delivery
8/1/17 → 7/31/18
Project: A - Government Institution › b - Ministry of Science and Technology
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Circuits of IGF-1R and Niche Signaling (Hypoxia/Inflammation) in Stem Cell Transformation and Its Clinical Implication of Molecular Target Therapy (Model of Germline Stem Cells)
8/1/11 → 7/31/12
Project: A - Government Institution › b - Ministry of Science and Technology
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Investigating the Effect of Chrna7-P38mapk Inflammatory Signaling Axis on Lipoprotein(A)-Induced Macrophage Polarization and Coronary Artery Spasm Development(1/3)
8/1/19 → 7/31/20
Project: A - Government Institution › b - Ministry of Science and Technology
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Epigenetic Editing as a Novel Therapeutics for Gynecological Cancer
8/1/16 → 7/31/17
Project: A - Government Institution › b - Ministry of Science and Technology
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The Role and Mechanisms of Metabolomics in the Outcome of Acute Ischemic Stroke
8/1/17 → 7/31/18
Project: A - Government Institution › b - Ministry of Science and Technology
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Study on the Mechanism of Cross-Talk between Ahr and Autophagy, and Autophagy---Associated Physiological or Pathological Phenomenon on Vascular and Airway Systems (I)
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標： 目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二：研究E1A抑制GRP78表現之分子機轉 目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Molecular Mechanisms of Secretory Rab Gtpase 3c in Promoting Colon Cancer Metastasis(3/3)
8/1/19 → 7/31/20
Project: A - Government Institution › b - Ministry of Science and Technology
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Statin Inhibits Pressured-Induced Rat Renal Tubular Cell Apoptosis and Tubulointerstitial Fibrosis
8/1/10 → 7/31/11
Project: A - Government Institution › b - Ministry of Science and Technology
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Dissected the Role of Glucose-Regulated Protein 94 (GRP94),The Clinically Therapeutic Implication and Drug Development in Colon Cancer
8/1/15 → 7/31/16
Project: A - Government Institution › b - Ministry of Science and Technology
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Role of Activating Transcription Factor 3 in the Protective Effect of Resveratrol in Cardiomyocytes
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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A Toxicological Assessment of Air Pollution in the Vicinity of a Petrochemical Complex
8/1/15 → 7/31/16
Project: A - Government Institution › b - Ministry of Science and Technology
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Investigation on Developing Novel Biomarkers and Treatments in the Patients with Fibromyalgia
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Nano-Scaffolds Enhance the Survival Rate of Immature Cryopreserved Testicular Tissue in Transplantation - Transgenic Mouse Model
8/1/17 → 7/31/18
Project: A - Government Institution › b - Ministry of Science and Technology
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Trajectories, Predictors of Return-to-Work, and the Impact of Return-to-Work in Predicting the Quality-of-Life among Workers with Traumatic Limb Injuries
8/1/12 → 7/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
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The Effects of the APOE4 Allele on Cerebral Structural and Functional Connectivity---A Diffusion Tensor Imaging and Resting-State MRI Study
Chen, C.
8/1/14 → 7/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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The Protective Role of Hmg-Coa Reductase Inhibitor，Statins，In Postoperative Complications and Survival of Critically Ill Subjects(3/3)
8/1/19 → 7/31/20
Project: A - Government Institution › b - Ministry of Science and Technology
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Psychophysiological Effects of Lactobacillus Plantarum Ps128 in Patients with Major Depressive Disorder: an 8-Week Randomized, Double-Blind, Placebo-Controlled Trial
8/1/19 → 7/31/20
Project: A - Government Institution › b - Ministry of Science and Technology
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A Study on Trans-Neuronal Striato-Nigral Degeneration-Induced Movement Disorders after Stroke---Evaluation with Grey Matter Suppression Ir and Diffusion Tensor Imaging (III)
8/1/14 → 10/31/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Investigation of the cerebral perfusion changes in patients with mild traumatic brain injury using 3D bSSFP arterial spin labeling MRI
Liu, H., Tsai, P., Chen, C. & Lu, C.
2/1/16 → 1/31/17
Project: A - Government Institution › b - Ministry of Science and Technology
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Studies of Cxcl12 in Hypoxia-Induced Pulmonary Fibrosis
8/1/12 → 10/31/13
Project: A - Government Institution › b - Ministry of Science and Technology
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Investigation of Chromatin Remodeling and Akt-Dependnet mTOR/S6K Mediate Thrombin-Induced IL-8/CXCL8 in Lung Epithelial Cells
8/1/10 → 7/31/11
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects of Genetic Polymorphisms on Efficacy and Safety of Opioid Analgesics in Patients with Postoperative Pain in a Taiwanese Population
8/1/18 → 10/1/19
Project: A - Government Institution › b - Ministry of Science and Technology
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Wearable Medical Modnles with Far Infrared Light and Microwave Pules Measurement (Emphasis Theme:A3)(3/3)
5/1/19 → 7/31/20
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects of Plasmon-Activated Water on the Microbiota of Inflammatory Bowel Disease, Crohn’S Disease and Ulcerative Colitis, by Drug-Induced and Transgenic Mouse Models
8/1/19 → 7/31/20
Project: A - Government Institution › b - Ministry of Science and Technology
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Effects of Uteroplacental Insufficiency and Hyperoxia on Lung Development and Epigenetic Alterations in the Rat Offspring(3/3)
8/1/16 → 7/31/17
Project: A - Government Institution › b - Ministry of Science and Technology
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Modulation of Tumor Microenvironment by Nucleic Acid Chimeras as a New Paradigm for Adjuvant Cancer Therapy
1/1/12 → 7/31/12
Project: A - Government Institution › b - Ministry of Science and Technology
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可攜式生物回饋與電刺激吞嚥訓練治療儀之研發與臨床應用
11/1/13 → 6/30/15
Project: A - Government Institution › b - Ministry of Science and Technology
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Characterization of Thalamocortical Dysrhythmia in Mild Traumatic Brain Injury Using Simultaneous Mri and Eeg Measurements and Pre-Clinical N-Acetylcysteine Treatment Response
8/1/17 → 7/31/18
Project: A - Government Institution › b - Ministry of Science and Technology
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The Determinant Clinical Parameters for Shifting Prescriptions among Nifedipine+Quercetin; Atorvastatin, and Captopril+Quercetin in Treating the Hypertension of Chronic Kidney Disease
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Investigating the Role of Ck1 Delta in Tumor Progression, and as a Therapeutic Target for New Drug Discovery in Bladder Cancer.
8/1/18 → 7/1/19
Project: A - Government Institution › b - Ministry of Science and Technology
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A study of diffusion tensor imaging as a potential surrogate marker for the management of acute ischemic cerebral stroke: A clinical and animal model at 7T
8/1/13 → 10/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Therapeutic Potentials of Exosomes from Mesenchymal Stem Cell on Mitigating Cardiac Alterations and Their Effects on Modulating Oxidation, Inflammation, Mitochondrial Dysfunction and Insulin Resistance in Obesity Mice and Obesity Mice with Sepsis
8/1/19 → 7/31/20
Project: A - Government Institution › b - Ministry of Science and Technology
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Biomechanical Comparison of Warm-Up Strategies for Preventing Achilles Tendon Injury
Chen, H.
8/1/16 → 8/31/17
Project: A - Government Institution › b - Ministry of Science and Technology
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Chitosan nanoparticle as a macrophage-targeting drug delivery carrier
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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Epigenetic Editing as a Novel Therapeutics for Gynecological Cancer
8/1/17 → 7/31/18
Project: A - Government Institution › b - Ministry of Science and Technology
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無機砷暴露、抽菸及微型核醣核酸表現與泌尿道上皮癌之相關性研究
9/1/15 → 8/31/16
Project: A - Government Institution › b - Ministry of Science and Technology
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電漿活化水對潰瘍性大腸炎及克隆氏症等腸道炎症微生物菌叢的影響-由藥物誘導鼠及基因轉殖鼠探討(2/2)
8/1/20 → 7/1/21
Project: A - Government Institution › b - Ministry of Science and Technology
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以anti-FAP/anti-CD3雙功能抗體武裝之毒殺型T細胞搭配臨床化療藥物治療腫瘤纖維化之胰臟癌
7/1/20 → 2/1/21
Project: A - Government Institution › b - Ministry of Science and Technology
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Study the Role of GRP78 in E1A-Mediated Metastasis Suppression of Breast Cancer
Wang, W. & Wu, C.
8/1/15 → 7/31/16
Project: A - Government Institution › b - Ministry of Science and Technology
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CXCL5/CXCR2/JNK Axis Is the Shared Pathway of Neuroinflammation and Microvascular Damage That Contributes to White Matter Injury in the Immature Brain
Huang, C.
8/1/15 → 7/31/16
Project: A - Government Institution › b - Ministry of Science and Technology
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Nutritional Ketosis on Cardiac Metabolism, Remodeling, and Arrhythmogenesis in Heart Failure: a Novel Stagey in Restoring Heart Function and Electrical Integrity
8/1/19 → 7/31/20
Project: A - Government Institution › b - Ministry of Science and Technology
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Association Study of Persistent Metabolic Syndrome, Inflammatory Markers and Mild Cognitive Decline
8/1/13 → 7/31/14
Project: A - Government Institution › b - Ministry of Science and Technology
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New Brain Cortical Electrical Stimulation Technology for the Neurorehabilitation Therapy of Bladder Dysfunction in the Parkinson’S Disease Animal Model(2/3)
8/1/18 → 7/1/19
Project: A - Government Institution › b - Ministry of Science and Technology
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Molecular Mechanisms of Secretory Rab Gtpase 3c in Promoting Colon Cancer Metastasis(1/3)
8/1/17 → 7/31/18
Project: A - Government Institution › b - Ministry of Science and Technology
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Environment-Sensitive Chitosan Nanomicelles for Ph-Jump Activation, Oxygen Evolution and Anticancer Drug Delivery(2/2)
8/1/18 → 10/31/19
Project: A - Government Institution › b - Ministry of Science and Technology
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Developing Rehabilitation and Exercise Guideline for Patients Receiving Advanced Surgery by Functional Approach Based on the International Classification of Functioning, Disability and Health (Icf)
8/1/18 → 7/1/19
Project: A - Government Institution › b - Ministry of Science and Technology