School of Medicine

Projects

Projects per year 2010 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022

• 2 Not started
• 165 Active
• 2033 Finished

Projects per year

Search results

• b - Ministry of Science and Technology

  The Further Investigation of Drugs Resistance Mechanism in Lung Cancer with Lung Fibrosis

  Chang, C.

  1/1/18 → 12/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Lung Neoplasms 100%
  • Lung 97%
  • Fibrosis 93%
  • Adenocarcinoma of Lung 60%
  • Proto-Oncogene Proteins c-met 38%

• The Roles of Microrna Sponge-Like Long Non-Coding Rnas (Lncrnas) in Progression and Temozolomide Chemoresistance of Glioblastoma(3/3)

  Chen, K.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 結合奈米診斷治療、影像免疫基因圖譜與人工智慧於原發性與再復發膠質母細胞瘤之研究-開發新穎結構小分子抑制劑用來抑制血管生成和腫瘤微環境以治療原發性及復發性多型性神經膠質母細胞腦瘤患者(2/3)

  Huang, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of Glioblastoma Cell-Secreted microRNA Signatures and Their Functional Effects on Tumor Angiogenesis

  Chen, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Circulating MicroRNA 100%
  • Glioblastoma 91%
  • MicroRNAs 54%
  • Temozolomide 35%
  • Glioma 26%

• Mechanistic Exploration of the Role of SCUBE2 in Suppressing the Generation of Cancer Stem Cells and Its Potential in Developing Novel Therapeutics (III)

  Chao, T.

  5/1/14 → 4/30/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Reflecting on Issues of End-Of-Life by Approaching Ventilator-Dependent Patients: an Interdisciplinary Educational Action Research

  Chen, C., Lin, W., Lin, S. & Tang, K.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • team teaching 100%
  • action research 70%
  • curriculum 64%
  • medicine 57%
  • dialogue 56%

• Application and Mechanism of Novel Fluoro-Rutaecarpine on Inhibition of Inflammation Induced Endomt

  Lin, C.

  8/1/14 → 12/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Fibrosis 19%
  • Inflammation 15%
  • Sumoylation 5%

• Association Study of Persistent Metabolic Syndrome, Inflammatory Markers, Adipose Markers and Mild Cognitive Decline

  Bai, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Cognitive Dysfunction 100%
  • Metabolic Syndrome 67%
  • Mental Status and Dementia Tests 50%
  • Thromboplastin 27%
  • Waist Circumference 24%

• 發展具有靶向及溶解血栓功能的奈米藥物治療平台(1/2)

  Mi, F.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 配對式神經調控模式應用於脊髓損傷者之前瞻神經復健技術開發-子計畫三：運用跨模態多項次神經影像技術探討神經調控模式對脊髓損傷者之神經可塑性與功能變化(3/3)

  Chan, W. P.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 競爭性內源RNA-BC200調控網絡誘導腦瘤中嘌呤體形成之分子機制與臨床意義

  Lin, J.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Physiological Predictors of Concurrent Cardiovascular Diseases in Bipolar Disorder

  Chen, P.

  8/1/15 → 10/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Bipolar Disorder 100%
  • Cardiovascular Diseases 85%
  • Mortality 22%
  • Psychiatry 21%
  • Hospitalization 21%

• 探討缺氧誘導之 lncRNA MIR210HG 在腦瘤惡性進程及促進 temozolomide 藥物抗藥性機轉中角色，並評估其作為腦瘤治療標的之可行性

  Chen, K.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 以新式片狀細胞工學製備自體片狀心肌細胞及其應用在缺血性心臟病的動物模式

  Tseng, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 降解型細胞自噬藉由促進微小RNA miR-449a表現量抑制大腸直腸癌之進程進而發展治療大腸癌之新策略(2/2)

  Wu, S.

  6/1/21 → 5/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 發展以表面增強拉曼光譜檢測農藥之策略

  Liu, Y.

  6/1/21 → 5/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 支援在地老化之智慧生活實驗室規畫(3/3)

  Tsai, D.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Transgenerational Epigenetic Reprogramming of Neuronal Maturation by Early-Life Maternal Sleep Deprivation( I )

  Yang, C. H.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Maternal Deprivation 100%
  • Sleep Deprivation 86%
  • Epigenomics 63%
  • Sleep 32%
  • Puberty 22%

• Fucoidan/Urokinase Assembled Magnetic Nanoparticles for the Detection of Thrombosis and Targeted Thrombolytic Therapy

  Mi, F.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of High-Quality Esport Seats Using Anti-Bedsore and Physiological Monitoring Techniques

  Chen, H.

  11/1/19 → 10/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Ergonomics 100%
  • Seats 99%
  • Headphones 67%
  • Industry 62%
  • Motion analysis 55%

• Reactions of NSAIDs (Mefenamic Acid and Diclofenac) by O3/Gac Processes: Intermediates, Pathway and Kinetic Models

  Chang, E.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • acid 100%
  • drug 86%
  • ozonation 57%
  • PPCP 35%
  • oxidation 34%

• The Measure of Palliative Care Spiritual Care Competency and the Effectiveness of an Educational Program for Palliative Spiritual Care Providers

  Chiou, J.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Palliative Care 100%
  • Program Evaluation 46%
  • Education 32%
  • Research Design 24%
  • Learning 15%

• Chitosan nanoparticle as a macrophage-targeting drug delivery carrier

  Mi, F.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Reactive Oxygen Metabolite 100%
  • Nanoparticle 63%
  • Folate 50%
  • Superoxide 41%
  • Chitosan 34%

• The effect of endothelin-1 on myofibroblast transformation of pleural mesothelial cells and its implications for pleural and pulmonary fibrosis

  Chung, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Myofibroblasts 100%
  • Endothelin-1 85%
  • Fibrosis 70%
  • Pulmonary Fibrosis 54%
  • Epithelial-Mesenchymal Transition 49%

• Studies on the Role of ORMDL3 in Thrombin-Induced IL-8/CXCL8 Expression and Airway Inflammation

  Chen, B.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Orosomucoid 100%
  • Thrombin 74%
  • Interleukin-8 34%
  • Transcription Factor AP-1 26%
  • Asthma 23%

• Reconstruction of Vertebral Body with Delayed Posttraumatic Vertebral Collapse---Biomechanical Evaluation and Redesign

  Chen, H.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • vertebrae 100%
  • mechanical testing 50%
  • spine (bones) 47%
  • surgery 43%
  • bones 36%

• T細胞耗竭在腎臟移植患者中所扮演的角色

  Wu, M.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Beta 3腎上腺素信號傳導對心律異常的發生：從心室心肌細胞中心臟代謝，氧化壓力和鈣離子恆定的見解

  Hsieh, M.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 電子菸的心房電生理影響動物模式 – 對電子菸致心房心律失常潛在威脅的研究

  Lin, Y.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 牙周致病菌加劇腹主動脈瘤生成的機制與開發標靶治療的可行性研究(1/3)

  Lin, F.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Glucagon-Like Peptide-1 in the Regulation of PPARs and Calcium Handling in Hyperglycemia or Hypertensive HL-1 Cells

  Huang, J.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glucagon-Like Peptide 1 100%
  • Peroxisome Proliferator-Activated Receptors 80%
  • Calcium 38%
  • Hyperglycemia 25%
  • Calcium-Transporting ATPases 22%

• Kidney Injury and Heat Shock Protein Modulate the Atrial Electrophysiological Characterisitcs

  Hsieh, M., Chen, Y. & Lin, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Chronic Renal Insufficiency 100%
  • Atrial Fibrillation 87%
  • Heat-Shock Proteins 68%
  • Indican 66%
  • Neomycin 41%

• Role of Organic Anion Transporter in Renal Tubular Injury---A Gateway to Hurt

  Wu, M.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of ADAM 17 in Hypoxia-Induced CTGF Expression and Pulmonary Fibrosis (III)

  Chen, B.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • ADAM17 Protein 100%
  • Connective Tissue Growth Factor 83%
  • Hypoxia 49%
  • Small Interfering RNA 38%
  • Fibrosis 21%

• 利用超高速藥物篩選平台鑑定活化轉錄因子3之小分子活化劑及其對慢性腎臟病之治療效果

  Chen, H.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 樹突細胞PD-L1/PD-L2失調在COPD 異常發炎的角色及機制探討(2/3)

  Lee, K.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Whole Organ Decellularizationtrachea Scaffold Tissue Engineering for Whole Segment Tracheal Transplantation/Replacement

  Hung, S., Lee, F. & Tseng, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • trachea (vertebrates) 100%
  • cartilage 77%
  • sonication 70%
  • tissues 27%
  • skeleton 25%

• Anxiety, Depression and Coronary Spasm: a Synthesis of Epidemiological and Experimental Studies

  Hung, M.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Spasm 100%
  • Coronary Vessels 78%
  • Anxiety 22%
  • Coronary Artery Disease 22%
  • Depression 17%

• Implantable Artificial Kidney Utilizing Nano-Porous Micro Tube Array Membrane Proof of Concept Study

  Wu, M.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 具遠外線與微波脈波測量的穿載式醫療模組- 封裝與驗證(重點主題:A3)

  Chen, C.

  5/1/20 → 4/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 科研創業計畫：回饋式呼吸引導暨預警系統-應用於遠距呼吸道復原照護

  Tseng, C.

  7/1/21 → 6/30/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Studies on the carcinogenic mechanisms of histamine N-methyltransferase-mediated breast cancer formation

  Wu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histamine N-Methyltransferase 100%
  • Breast Neoplasms 18%
  • Neoplasms 6%
  • Carcinogenesis 6%

• Translational Genomic Approaches in Endometriosis

  Tzeng, C., Huang, Y., Li, Y., Yang, W., Shen, S. & Kao, S.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

  • endometrium 100%
  • microRNA 90%
  • stem cells 61%
  • cell adhesion molecules 54%
  • metastasis 35%

• 榖胱甘月太硫轉移酉每參與乳癌致癌之分子機制探討(2/3)

  Wu, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Characterization of Thalamocortical Dysrhythmia in Mild Traumatic Brain Injury Using Simultaneous Mri and Eeg Measurements and Pre-Clinical N-Acetylcysteine Treatment Response

  Chen, C., Liu, H., Tseng, S., Lane, T. J., Lu, C., Chiang, Y. & Tsai, P.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Acetylcysteine 44%
  • Post-Concussion Syndrome 17%
  • Neuroimaging 15%
  • Electroencephalography 14%
  • Atrophy 9%

• 乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標： 目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二：研究E1A抑制GRP78表現之分子機轉 目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。

  Wang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • glucose-regulated proteins 100%
  • Neoplasm Metastasis 25%
  • Neoplasms 23%
  • Breast Neoplasms 16%
  • Psychological Inhibition 12%

• Translational Genomic Approaches in Endometriosis

  Tzeng, C., Huang, Y., Shen, S., Yang, W., Li, Y., Yeh, C. & Kao, S.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

  • endometrium 100%
  • microRNA 90%
  • stem cells 61%
  • cell adhesion molecules 54%
  • metastasis 35%

• Dissected the role of Glucosed-regulated portein 78 in the progression, metastasis and therapy of colorectal cancer

  Wei, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

  • colorectal neoplasms 100%
  • metastasis 69%
  • neoplasms 55%
  • endoplasmic reticulum 32%
  • death 27%

• Study the Role of the Endoplasmic Reticulum Stress Related Proteins, Glycoprotein 96(Gp96), in Liver Cancer Progression and Metastasis and the Clinically Therapeutic Implication

  Huang, M.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Glycoproteins 100%
  • Heat-Shock Proteins 36%
  • Endoplasmic Reticulum Stress 26%
  • Liver Neoplasms 23%
  • Neoplasm Metastasis 21%

• Dissected the Role of Thrombomodulin in the Clinical Diagnostic and Therapeutic Impacts for Breast Cancer and the Regulation Mechanisms

  Hung, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Thrombomodulin 100%
  • Breast Neoplasms 90%
  • Therapeutics 20%
  • Neoplasms 12%
  • Steroid Receptors 11%