Research Center of Thoracic Medicine-Asthma

Research Output 1994 2020

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2020

Mammalian target of rapamycin and p70S6K mediate thrombin-induced nuclear factor-κB activation and IL-8/CXCL8 release in human lung epithelial cells

Lin, C. H., Shih, C. H., Jiang, C. P., Wen, H. C., Cheng, W. H. & Chen, B. C., Feb 5 2020, In : European Journal of Pharmacology. 868, 172879.

Research output: Contribution to journalArticle

Complement Factor B
Sirolimus
Interleukin-8
Thrombin
Phosphotransferases
1 Citation (Scopus)

N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression

Mehndiratta, S., Lin, M. H., Wu, Y. W., Chen, C. H., Wu, T. Y., Chuang, K. H., Chao, M. W., Chen, Y. Y., Pan, S. L., Chen, M. C. & Liou, J. P., Jan 1 2020, In : European Journal of Medicinal Chemistry. 185, p. 111725 111725.

Research output: Contribution to journalArticle

Anilides
HSP90 Heat-Shock Proteins
Histone Deacetylase Inhibitors
Histone Deacetylases
Down-Regulation

Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment

Kaur, N., Fang, Y. C., Lee, H. Y., Singh, A., Nepali, K., Lin, M. H., Yeh, T. K., Lai, M. J., Chan, L., Tu, Y. K., Banerjee, S., Hu, C. J. & Liou, J. P., Feb 1 2020, In : European Journal of Medicinal Chemistry. 187, 111915.

Research output: Contribution to journalArticle

Azepines
Histone Deacetylase Inhibitors
Blood Vessels
Acetylation
Acrylamide
2019
5 Citations (Scopus)

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

Benzamides
Histone Deacetylases
Tubulin
Heterografts
Inhibitory Concentration 50
Curcumin
Endothelin-1
Fibroblasts
Thrombin
Phosphotransferases
3 Citations (Scopus)

Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivo

Hsieh, Y. L., Tu, H. J., Pan, S. L., Liou, J. P. & Yang, C. R., Jun 1 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 6, p. 992-1003 12 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Histone Deacetylase Inhibitors
Breast Neoplasms
Histone Deacetylases
Acetylation
1 Citation (Scopus)

Association between exposures to air pollution and biomarkers of cardiovascular disease in Northern Taiwan

Pangaribuan, M., Chuang, K. J. & Chuang, H. C., Jul 1 2019, In : Atmospheric Pollution Research. 10, 4, p. 1250-1259 10 p.

Research output: Contribution to journalArticle

cardiovascular disease
Biomarkers
Air pollution
Blood pressure
biomarker
1 Citation (Scopus)
Open Access
Penfluridol
Unfolded Protein Response
Lung Neoplasms
Cell Death
Adenosine Triphosphate
4 Citations (Scopus)

Characterization of the chemical components and bioreactivity of fine particulate matter produced during crop-residue burning in China

Chuang, H-C., Sun, J., Ni, H., Tian, J., Lui, K. H., Han, Y., Cao, J., Huang, R-J., Shen, Z. & Ho, K-F., Feb 2019, In : Environmental Pollution. 245, p. 226-234 9 p.

Research output: Contribution to journalArticle

Particulate Matter
Organic carbon
Crops
China
Oxidoreductases
2 Citations (Scopus)
Pulmonary diseases
pneumonia
Air pollution
atmospheric pollution
confidence interval

Comparison of cytotoxicity induced by PM2.5-bound polycyclic aromatic compounds from different environments in Xi'an, China

Niu, X., Ho, K. F., Chuang, H. C., Sun, J., Huang, Y., Hu, T., Xu, H., Duan, J., Lui, K. H. & Cao, J., Nov 1 2019, In : Atmospheric Environment. 216, 116929.

Research output: Contribution to journalArticle

PAH
suburban area
urban area
phenanthrene
pyrene
1 Citation (Scopus)

Contributions of local pollution emissions to particle bioreactivity in downwind cities in China during Asian dust periods

Ho, K. F., Wu, K. C., Niu, X., Wu, Y., Zhu, C. S., Wu, F., Cao, J. J., Shen, Z. X., Hsiao, T. C., Chuang, K. J. & Chuang, H. C., Feb 1 2019, In : Environmental Pollution. 245, p. 675-683 9 p.

Research output: Contribution to journalArticle

Dust
China
Pollution
Vehicle Emissions
Cell Survival
2 Citations (Scopus)
Chronic Obstructive Pulmonary Disease
Odds Ratio
Propensity Score
Geriatrics
Length of Stay

Differences between COPD patients and their families regarding willingness toward life-sustaining treatments

Chen, T. R., Hu, W. Y., Chiu, T. Y. & Kuo, H. P., Jan 2019, (Accepted/In press) In : Journal of the Formosan Medical Association. 118, 1P3, p. 414-419

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Therapeutics
Medical Futility
Persistent Vegetative State
Noninvasive Ventilation

Endothelin-1 Induces Mesothelial Mesenchymal Transition and Correlates with Pleural Fibrosis in Tuberculous Pleural Effusions

Wu, Z-H., Tsai, J-H., Hsieh, C-Y., Chen, W-L. & Chung, C-L., Mar 29 2019, In : Journal of Clinical Medicine. 8, 4, 426.

Research output: Contribution to journalArticle

Endothelin-1
Pleural Effusion
Fibrosis
Extracellular Matrix
Pleural Diseases
2 Citations (Scopus)

Endotypes of severe allergic asthma patients who clinically benefit from anti-IgE therapy

Huang, Y. C., Weng, C. M., Lee, M. J., Lin, S. M., Wang, C. H. & Kuo, H-P., Jan 1 2019, In : Clinical and Experimental Allergy. 49, 1, p. 44-53 10 p.

Research output: Contribution to journalArticle

Asthma
Therapeutics
Cytokines
Inflammation
anti-IgE antibodies
Ionizing radiation
Ionizing Radiation
Interferons
Cytotoxicity
STAT1 Transcription Factor
3 Citations (Scopus)

Functional neutralization of anti-IFN-γ autoantibody in patients with nontuberculous mycobacteria infection

Krisnawati, D. I., Liu, Y. C., Lee, Y. J., Wang, Y. T., Chen, C. L., Tseng, P. C. & Lin, C. F., Apr 5 2019, In : Scientific Reports. 9, 1, p. 5682 5682.

Research output: Contribution to journalArticle

Open Access
Nontuberculous Mycobacterium Infections
Autoantibodies
Interferons
Serum
Chemokines
1 Citation (Scopus)

Impacts of in-cabin exposure to size-fractionated particulate matters and carbon monoxide on changes in heart rate variability for healthy public transit commuters

Tang, C. S., Wu, T. Y., Chuang, K. J., Chang, T. Y., Chuang, H. C., Lung, S. C. C. & Chang, L. T., Jul 1 2019, In : ATMOSPHERE. 10, 7, 409.

Research output: Contribution to journalArticle

Open Access
carbon monoxide
particulate matter
public
rate
exposure

Indoor ozone levels, houseplants and peak expiratory flow rates among healthy adults in Taipei, Taiwan

Chang, L. T., Hong, G. B., Weng, S. P., Chuang, H. C., Chang, T. Y., Liu, C. W., Chuang, W. Y. & Chuang, K. J., Jan 1 2019, In : Environment International. 122, p. 231-236 6 p.

Research output: Contribution to journalArticle

peak flow
isoprene
ozone
indoor air
summer

Induction of Fibrosis and Autophagy in Kidney Cells by Vinyl Chloride

Hsu, Y-H., Chuang, H-C., Lee, Y-H., Lin, Y-F., Chiu, Y-J., Wang, Y-L., Wu, M-S. & Chiu, H-W., Jun 17 2019, In : Cells. 8, 6

Research output: Contribution to journalArticle

Vinyl Chloride
Autophagy
Fibrosis
Kidney
Tissue
Airway Remodeling
Matrix Metalloproteinases
Asthma
Antibodies
thymic stromal lymphopoietin

Microglial activation and inflammation caused by traffic-related particulate matter

Bai, K. J., Chuang, K. J., Chen, C. L., Jhan, M. K., Hsiao, T. C., Cheng, T. J., Chang, L. T., Chang, T. Y. & Chuang, H. C., Sep 25 2019, In : Chemico-Biological Interactions. 311, 108762.

Research output: Contribution to journalArticle

Soot
Vehicle Emissions
Particulate Matter
Chemical activation
Inflammation
1 Citation (Scopus)

MPT0G413, A novel HDAC6-selective inhibitor, and bortezomib synergistically exert anti-tumor activity in multiple myeloma cells

Huang, F. I., Wu, Y. W., Sung, T. Y., Liou, J. P., Lin, M. H., Pan, S. L. & Yang, C. R., Jan 1 2019, In : Frontiers in Oncology. 9, APR, p. 249 249.

Research output: Contribution to journalArticle

Open Access
Histone Deacetylases
Multiple Myeloma
Neoplasms
Histone Deacetylase Inhibitors
Growth
Open Access
Colorectal Neoplasms
Apoptosis
Ligands
Autophagy
Cell Death

Pilot Studies of VOC Exposure Profiles during Surgical Operations

Cheng, N-Y., Chuang, H-C., Shie, R-H., Liao, W-H. & Hwang, Y-H., Feb 16 2019, In : Annals of Work Exposures and Health. 63, 2, p. 173-183 11 p.

Research output: Contribution to journalArticle

Operating Rooms
Methacrylates
Benzene
Organic Chemicals
Volatile Organic Compounds
Haptoglobins
Chronic Obstructive Pulmonary Disease
Inflammation
Phenotype
Alveolar Epithelial Cells
3 Citations (Scopus)
Urinary Bladder Neoplasms
Antineoplastic Agents
G1 Phase
Ovarian Neoplasms
Solubility
1 Citation (Scopus)
Open Access
Autophagy
Fibroblast Growth Factor Receptors
Neoplasms
Drug Combinations
gemcitabine
Open Access
Tissue Inhibitor of Metalloproteinase-3
Colorectal Neoplasms
Neoplasm Metastasis
Growth
Neoplasms
5 Citations (Scopus)

Traffic-related particulate matter exposure induces nephrotoxicity in vitro and in vivo

Hsu, Y. H., Chuang, H. C., Lee, Y. H., Lin, Y. F., Chen, Y. J., Hsiao, T. C., Wu, M. Y. & Chiu, H. W., May 1 2019, In : Free Radical Biology and Medicine. 135, p. 235-244 10 p.

Research output: Contribution to journalArticle

Open Access
Particulate Matter
Autophagy
Air Pollution
Air pollution
Kidney
2018
17 Citations (Scopus)

(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo

Lee, H. Y., Nepali, K., Huang, F. I., Chang, C. Y., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Feb 8 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 905-917 13 p.

Research output: Contribution to journalArticle

Quinolines
Histone Deacetylase Inhibitors
Multiple Myeloma
Growth
Hydroxamic Acids
8 Citations (Scopus)

1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC

Ojha, R., Huang, H. L., HuangFu, W. C., Wu, Y. W., Nepali, K., Lai, M. J., Su, C. J., Sung, T. Y., Chen, Y. L., Pan, S. L. & Liou, J. P., Apr 25 2018, In : European Journal of Medicinal Chemistry. 150, p. 667-677 11 p.

Research output: Contribution to journalArticle

Hydroxamic Acids
Histone Deacetylase Inhibitors
Antineoplastic Agents
Protein Isoforms
Cells
1 Citation (Scopus)

4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy

Lin, S. Y., Yeh, T. K., Song, J. S., Hung, M. S., Cheng, M. F., Liao, F. Y., Li, A. S., Cheng, S. Y., Lin, L. M., Chiu, C. H., Wu, M. H., Lin, Y. J., Hsiao, W., Sun, M., Wang, Y. H., Huang, C. H., Tang, Y. C., Chang, H. H., Huang, Z. T., Chao, Y. S. & 5 others, Shih, C., Pan, S. L., Wu, S. Y., Kuo, C. C. & Ueng, S. H., Apr 1 2018, In : Bioorganic Chemistry. 77, p. 600-607 8 p.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Tumors
Neoplasms
T-cells
Pharmaceutical Preparations
12 Citations (Scopus)

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes

Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Jan 29 2018, (Accepted/In press) In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

tau Proteins
Histone Deacetylase Inhibitors
Alzheimer Disease
Hydroxamic Acids
Phenotype

ADAM17/EGFR-dependent ERK activation mediates thrombin-induced CTGF expression in human lung fibroblasts

Chen, H. Y., Lin, C. H. & Chen, B. C., Sep 1 2018, In : Experimental Cell Research. 370, 1, p. 39-45 7 p.

Research output: Contribution to journalArticle

Connective Tissue Growth Factor
Disintegrins
Extracellular Signal-Regulated MAP Kinases
Metalloproteases
Epidermal Growth Factor Receptor

Analysis of Titin in Red and White Muscles: Crucial Role on Muscle Contractions Using a Fish Model

Wu, M. P., Chang, N. C., Chung, C. L., Chiu, W. C., Hsu, C. C., Chen, H. M., Sheu, J. R., Jayakumar, T., Chou, D. S. & Fong, T. H., Nov 18 2018, In : BioMed Research International. 2018, p. 5816875 11 p., 5816875.

Research output: Contribution to journalArticle

Connectin
Muscle Contraction
Fish
Muscle
Muscles

An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets

Lu, W. J., Chung, C. L., Chen, R. J., Huang, L. T., Lien, L. M., Chang, C. C., Lin, K. H. & Sheu, J. R., Nov 14 2018, In : Journal of Clinical Medicine. 7, 11

Research output: Contribution to journalArticle

Phospholipase D
Blood Platelets
Platelet Activation
Platelet Aggregation
Thrombosis
3 Citations (Scopus)

A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo

Wu, Y. W., Hsu, K. C., Lee, H. Y., Huang, T. C., Lin, T. E., Chen, Y. L., Sung, T. Y., Liou, J. P., Hwang-Verslues, W. W., Pan, S. L. & HuangFu, W. C., Mar 13 2018, In : Frontiers in Pharmacology. 9, MAR, 205.

Research output: Contribution to journalArticle

Tubulin Modulators
Histone Deacetylases
Neoplasms
Tubulin
Molecular Docking Simulation

A Novel Selective JAK2 Inhibitor Identified Using Pharmacological Interactions

Lin, T. E., HuangFu, W-C., Chao, M-W., Sung, T-Y., Chang, C-D., Chen, Y-Y., Hsieh, J-H., Tu, H-J., Huang, H-L., Pan, S-L. & Hsu, K-C., 2018, In : Frontiers in Pharmacology. 9, p. 1379

Research output: Contribution to journalArticle

Janus Kinases
Phosphotransferases
Binding Sites
Pharmacology
Cytokine Receptors
2 Citations (Scopus)
Connective Tissue Growth Factor
Airway Remodeling
Matrix Metalloproteinases
Ovalbumin
Asthma
11 Citations (Scopus)

Aryl hydrocarbon receptor activation by diesel exhaust particles mediates epithelium-derived cytokines expression in severe allergic asthma

Weng, C. M., Wang, C. H., Lee, M. J., He, J. R., Huang, H. Y., Chao, M. W., Chung, K. F. & Kuo, H-P., Nov 1 2018, In : Allergy: European Journal of Allergy and Clinical Immunology. 73, 11, p. 2192-2204 13 p.

Research output: Contribution to journalArticle

Vehicle Emissions
Aryl Hydrocarbon Receptors
Interleukin-17
Asthma
Epithelium
11 Citations (Scopus)

Association of PM2.5 with sleep-disordered breathing from a population-based study in Northern Taiwan urban areas

Shen, Y. L., Liu, W. T., Lee, K. Y., Chuang, H. C., Chen, H. W. & Chuang, K. J., Feb 1 2018, In : Environmental Pollution. 233, p. 109-113 5 p.

Research output: Contribution to journalArticle

Air Pollution
Sleep Apnea Syndromes
Apnea
Air pollution
Taiwan
6 Citations (Scopus)

Association of ultrafine particles with cardiopulmonary health among adult subjects in the urban areas of northern Taiwan

Liu, J. Y., Hsiao, T. C., Lee, K. Y., Chuang, H. C., Cheng, T. J. & Chuang, K. J., Jun 15 2018, In : Science of the Total Environment. 627, p. 211-215 5 p.

Research output: Contribution to journalArticle

urban area
Health
Blood pressure
Air pollution
confidence interval
10 Citations (Scopus)
Protein-Tyrosine Kinases
Disease-Free Survival
Cytotoxic T-Lymphocytes
Bevacizumab
Myeloid-Derived Suppressor Cells
3 Citations (Scopus)

Chronic pulmonary exposure to traffic-related fine particulate matter causes brain impairment in adult rats

Shih, C. H., Chen, J. K., Kuo, L. W., Cho, K. H., Hsiao, T. C., Lin, Z. W., Lin, Y. S., Kang, J. H., Lo, Y. C., Chuang, K. J., Cheng, T. J. & Chuang, H. C., Nov 9 2018, In : Particle and Fibre Toxicology. 15, 1, 1 p.

Research output: Contribution to journalArticle

Particulate Matter
Rats
Brain
Hippocampus
Air Pollution
7 Citations (Scopus)

Cluster analysis of fine particulate matter (PM2.5) emissions and its bioreactivity in the vicinity of a petrochemical complex

Chuang, H. C., Shie, R. H., Chio, C. P., Yuan, T. H., Lee, J. H. & Chan, C. C., May 1 2018, In : Environmental Pollution. 236, p. A1

Research output: Contribution to journalArticle

8-epi-prostaglandin F2alpha
Industrial emissions
Particulate Matter
Cluster analysis
L-Lactate Dehydrogenase

Correction: 2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition (Org. Biomol. Chem. (2016) 14 (716-723))

Nepali, K., Kumar, S., Huang, H. L., Kuo, F. C., Lee, C. H., Kuo, C. C., Yeh, T. K., Li, Y. H., Chang, J. Y., Liou, J. P. & Lee, H. Y., Jan 1 2018, In : Organic and Biomolecular Chemistry. 16, 25, p. 4734 1 p.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
Dione
Tubulin
Antineoplastic Agents
Emotions

Decreased risk of pneumonia in stroke patients receiving acupuncture: A nationwide matched-pair retrospective cohort study

Chang, C. C., Chen, T. L., Lin, C. S., Chung, C. L., Yeh, C. C., Hu, C. J., Lane, H. L., Liao, C. C. & Shih, C. C., May 1 2018, In : PLoS One. 13, 5, e0196094.

Research output: Contribution to journalArticle

Open Access
Acupuncture
acupuncture
risk reduction
cohort studies
stroke

Design of diarylheptanoid derivatives as dual inhibitors against class IIa histone deacetylase and β-amyloid aggregation

Chen, L. C., Tseng, H. J., Liu, C. Y., Huang, Y. Y., Yen, C. C., Weng, J. R., Lu, Y. L., Hou, W. C., Lin, T. E., Pan, I. H., Huang, K. K., Huang, W. J. & Hsu, K. C., Jul 3 2018, In : Frontiers in Pharmacology. 9, JUL, 708.

Research output: Contribution to journalArticle

Diarylheptanoids
Histone Deacetylases
Amyloid
Alzheimer Disease
Pyrogallol