Research Output 2014 2020

  • 701 Citations
  • 15 h-Index
  • 69 Article
  • 3 Review article
2015
2 Citations (Scopus)
Acrylamide
Colorectal Neoplasms
Histone Deacetylases
Cadherins
Neoplasms
3 Citations (Scopus)

MT-4 suppresses resistant ovarian cancer growth through targeting tubulin and HSP27

Pai, H. C., Kumar, S., Shen, C. C., Liou, J. P., Pan, S. L. & Che, M. T., Apr 14 2015, In : PLoS One. 10, 4, e0123819.

Research output: Contribution to journalArticle

ovarian neoplasms
Tubulin
tubulin
Ovarian Neoplasms
apoptosis
7 Citations (Scopus)

Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo

Huang, H-L., Peng, C-Y., Lai, M-J., Chen, C-H., Lee, H. Y., Wang, J-C., Liou, J. P., Pan, S. L. & Teng, C-M., 2015, In : Oncotarget. 6, 7, p. 4976-4991 16 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
B-Cell Lymphoma
Human Activities
Growth
Apoptosis
16 Citations (Scopus)

N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling

Lai, M-J., Lee, H. Y., Chuang, H-Y., Chang, L-H., Tsai, A-C., Chen, M. C., Huang, H-L., Wu, Y-W., Teng, C-M., Pan, S. L., Liu, Y-M., Mehndiratta, S. & Liou, J. P., Aug 27 2015, In : Journal of Medicinal Chemistry. 58, 16, p. 6549-6558 10 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Tubulin
Phosphorylation
Polymerization
Antineoplastic Agents
7 Citations (Scopus)

Pyrimidinedione-mediated selective histone deacetylase 6 inhibitors with antitumor activity in colorectal cancer HCT116 cells

Liu, Y-M., Lee, H. Y., Lai, M-J., Pan, S. L., Huang, H-L., Kuo, F-C., Chen, M. C. & Liou, J. P., Aug 17 2015, In : Organic and Biomolecular Chemistry. 13, 40, p. 10226-10235 10 p.

Research output: Contribution to journalArticle

HCT116 Cells
Histone Deacetylase Inhibitors
Histone Deacetylases
Oncology
Poisons
26 Citations (Scopus)

The synergic effect of vincristine and vorinostat in leukemia in vitro and in vivo

Chao, M-W., Lai, M-J., Liou, J. P., Chang, Y-L., Wang, J-C., Pan, S. L. & Teng, C-M., Dec 12 2015, In : Journal of Hematology and Oncology. 8, 1, 176.

Research output: Contribution to journalArticle

Vincristine
Leukemia
Microtubules
Tubulin
Cell Survival
2014
25 Citations (Scopus)
Transforming Growth Factors
Angiotensin II
Androgens
Testosterone
Fibroblasts
7 Citations (Scopus)

A novel action mechanism for MPT0g013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through upregulation of TIMP3 expression

Wang, C-Y., Liou, J. P., Tsai, A-C., Lai, M-J., Liu, Y-M., Lee, H. Y., Wang, J-C., Pan, S. L. & Teng, C-M., 2014, In : Oncotarget. 5, 20, p. 9838-9850 13 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-3
Up-Regulation
Neoplasms
Cell Cycle Resting Phase
Proteins
22 Citations (Scopus)

A novel class I HDAC inhibitor, MPT0G030, induces cell apoptosis and differentiation in human colorectal cancer cells via HDAC1/PKCδ and E-cadherin

Wang, L. T., Liou, J. P., Li, Y. H., Liu, Y. M., Pan, S. L. & Teng, C. M., 2014, In : Oncotarget. 5, 14, p. 5651-5662 12 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Cadherins
Protein Kinase C
Cell Differentiation
Colorectal Neoplasms
7 Citations (Scopus)

Antimitotic and vascular disrupting agents: 2-Hydroxy-3,4,5- trimethoxybenzophenones

Chang, C. Y., Chuang, H. Y., Lee, H. Y., Yeh, T. K., Kuo, C. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., Apr 22 2014, In : European Journal of Medicinal Chemistry. 77, p. 306-314 9 p.

Research output: Contribution to journalArticle

Benzophenones
Antimitotic Agents
KB Cells
Endothelial cells
Human Umbilical Vein Endothelial Cells
33 Citations (Scopus)

Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells

Lee, H. Y., Tsai, A. C., Chen, M. C., Shen, P. J., Cheng, Y. C., Kuo, C. C., Pan, S. L., Liu, Y. M., Liu, J. F., Yeh, T. K., Wang, J. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., May 22 2014, In : Journal of Medicinal Chemistry. 57, 10, p. 4009-4022 14 p.

Research output: Contribution to journalArticle

HCT116 Cells
Histone Deacetylases
Colorectal Neoplasms
Histone Deacetylase Inhibitors
Heterografts
6 Citations (Scopus)

Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents

Mehndiratta, S., Chiang, Y-F., Lai, M-J., Lee, H. Y., Chen, M. C., Kuo, C-C., Chang, C-Y., Chang, J-Y. & Liou, J. P., Sep 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 17, p. 4917-4923 7 p.

Research output: Contribution to journalArticle

Antimitotic Agents
Blood Vessels
Cells
Cell Line
G2 Phase
10 Citations (Scopus)
Curcumin
Extracellular Matrix
Fibroblasts
Angiotensin II
Transforming Growth Factors
16 Citations (Scopus)

Denbinobin upregulates miR-146a expression and attenuates IL-1β-induced upregulation of ICAM-1 and VCAM-1 expressions in osteoarthritis fibroblast-like synoviocytes

Yang, C. R., Shih, K. S., Liou, J. P., Wu, Y. W., Hsieh, I. N., Lee, H. Y., Lin, T. C. & Wang, J. H., Oct 22 2014, In : Journal of Molecular Medicine. 92, 11, p. 1147-1158 12 p.

Research output: Contribution to journalArticle

Vascular Cell Adhesion Molecule-1
Intercellular Adhesion Molecule-1
MicroRNAs
Interleukin-1
Osteoarthritis
6 Citations (Scopus)

Effect of C7-substitution of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines on the selectivity towards a subclass of histone deacetylases

Lee, H. Y., Wang, L. T., Li, Y. H., Pan, S. L., Chen, Y. L., Teng, C. M. & Liou, J. P., Nov 28 2014, In : Organic and Biomolecular Chemistry. 12, 44, p. 8966-8976 11 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Tumors
Substitution reactions
selectivity
substitutes
17 Citations (Scopus)

Indole-3-ethylsulfamoylphenylacrylamides: Potent histone deacetylase inhibitors with anti-inflammatory activity

Mehndiratta, S., Hsieh, Y. L., Liu, Y. M., Wang, A. W., Lee, H. Y., Liang, L. Y., Kumar, S., Teng, C. M., Yang, C. R. & Liou, J. P., Oct 6 2014, In : European Journal of Medicinal Chemistry. 85, p. 468-479 12 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Histone Deacetylases
Cell Survival
Anti-Inflammatory Agents
Cells
13 Citations (Scopus)

Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2

Hou, P., Kuo, C. Y., Cheng, C. T., Liou, J. P., Ann, D. K. & Chen, Q., Nov 24 2014, In : PLoS One. 9, 11, e113865.

Research output: Contribution to journalArticle

procollagen-proline dioxygenase
Prolyl Hydroxylases
Hypoxia-Inducible Factor 1
Metabolites
metabolites
4 Citations (Scopus)

In vitro and in vivo anti-tumour effects of MPT0B014, a novel derivative aroylquinoline, and in combination with erlotinib in human non-small-cell lung cancer cells

Tsai, A. C., Pai, H. C., Wang, C. Y., Liou, J. P., Teng, C. M., Wang, J. C. & Pan, S. L., Jan 2014, In : British Journal of Pharmacology. 171, 1, p. 122-133 12 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Non-Small Cell Lung Carcinoma
lissamine rhodamine B
Neoplasms
Cyclin B1
14 Citations (Scopus)

Orally active microtubule-targeting agent, MPT0B271, for the treatment of human non-small cell lung cancer, alone and in combination with erlotinib

Tsai, A. C., Wang, C. Y., Liou, J. P., Pai, H. C., Hsiao, C. J., Chang, J. Y., Wang, J. C., Teng, C. M. & Pan, S. L., 2014, In : Cell Death and Disease. 5, 4, e1162.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Microtubules
Tubulin
Cyclin B1
Therapeutics
20 Citations (Scopus)

Preclinical anti-arthritic study and pharmacokinetic properties of a potent histone deacetylase inhibitor MPT0G009

Hsieh, I-N., Liou, J. P., Lee, H. Y., Lai, M-J., Li, Y-H. & Yang, C-R., 2014, In : Cell Death and Disease. 5, 4, e1166.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Arthritis
Pharmacokinetics
Histone Deacetylases
Oral Administration
32 Citations (Scopus)

Synergistic interaction between the HDAC inhibitor, MPT0E028, and sorafenib in liver cancer cells in vitro and in vivo

Chen, C. H., Chen, M. C., Wang, J. C., Tsai, A. C., Chen, C. S., Liou, J. P., Pan, S. L. & Teng, C. M., 2014, In : Clinical Cancer Research. 20, 5, p. 1274-1287 14 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Liver Neoplasms
Heterografts
Cell Survival
Histone Code
49 Citations (Scopus)

Tubulin inhibitors: A patent review

Liu, Y. M., Chen, H. L., Lee, H. Y. & Liou, J. P., Jan 2014, In : Expert Opinion on Therapeutic Patents. 24, 1, p. 69-88 20 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Microtubules
Spindle Apparatus
Tubulin
Neoplasms