Research Output

  • 758 Citations
  • 15 h-Index
  • 70 Article
  • 3 Review article
2020

N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression

Mehndiratta, S., Lin, M. H., Wu, Y. W., Chen, C. H., Wu, T. Y., Chuang, K. H., Chao, M. W., Chen, Y. Y., Pan, S. L., Chen, M. C. & Liou, J. P., Jan 1 2020, In : European Journal of Medicinal Chemistry. 185, p. 111725 111725.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment

Kaur, N., Fang, Y. C., Lee, H. Y., Singh, A., Nepali, K., Lin, M. H., Yeh, T. K., Lai, M. J., Chan, L., Tu, Y. K., Banerjee, S., Hu, C. J. & Liou, J. P., Feb 1 2020, In : European Journal of Medicinal Chemistry. 187, 111915.

Research output: Contribution to journalArticle

2019

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivo

Hsieh, Y. L., Tu, H. J., Pan, S. L., Liou, J. P. & Yang, C. R., Jun 1 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 6, p. 992-1003 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

MPT0G413, A novel HDAC6-selective inhibitor, and bortezomib synergistically exert anti-tumor activity in multiple myeloma cells

Huang, F. I., Wu, Y. W., Sung, T. Y., Liou, J. P., Lin, M. H., Pan, S. L. & Yang, C. R., Jan 1 2019, In : Frontiers in Oncology. 9, APR, p. 249 249.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
Open Access

Nitro-Group-Containing Drugs

Nepali, K., Lee, H. Y. & Liou, J. P., Mar 28 2019, In : Journal of Medicinal Chemistry. 62, 6, p. 2851-2893 43 p.

Research output: Contribution to journalReview article

36 Citations (Scopus)
3 Citations (Scopus)
Open Access
1 Citation (Scopus)
Open Access
1 Citation (Scopus)
2018

(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo

Lee, H. Y., Nepali, K., Huang, F. I., Chang, C. Y., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Feb 8 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 905-917 13 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC

Ojha, R., Huang, H. L., HuangFu, W. C., Wu, Y. W., Nepali, K., Lai, M. J., Su, C. J., Sung, T. Y., Chen, Y. L., Pan, S. L. & Liou, J. P., Apr 25 2018, In : European Journal of Medicinal Chemistry. 150, p. 667-677 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes

Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Jan 29 2018, (Accepted/In press) In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

14 Citations (Scopus)

A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo

Wu, Y. W., Hsu, K. C., Lee, H. Y., Huang, T. C., Lin, T. E., Chen, Y. L., Sung, T. Y., Liou, J. P., Hwang-Verslues, W. W., Pan, S. L. & HuangFu, W. C., Mar 13 2018, In : Frontiers in Pharmacology. 9, MAR, 205.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Correction: 2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition (Org. Biomol. Chem. (2016) 14 (716-723))

Nepali, K., Kumar, S., Huang, H. L., Kuo, F. C., Lee, C. H., Kuo, C. C., Yeh, T. K., Li, Y. H., Chang, J. Y., Liou, J. P. & Lee, H. Y., Jan 1 2018, In : Organic and Biomolecular Chemistry. 16, 25, p. 4734 1 p.

Research output: Contribution to journalArticle

Dual inhibition of PIK3C3 and FGFR as a new therapeutic approach to treat bladder cancer

Chen, C. H., Changou, C. A., Hsieh, T. H., Lee, Y. C., Chu, C. Y., Hsu, K. C., Wang, H. C., Lin, Y. C., Lo, Y. N., Liu, Y. R., Liou, J. P. & Yen, Y., Mar 1 2018, In : Clinical Cancer Research. 24, 5, p. 1176-1189 14 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Novel microtubule inhibitor MPT0B098 inhibits hypoxia-induced epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma

Tsai, I. T., Kuo, C. C., Liou, J. P. & Chang, J. Y., Mar 28 2018, In : Journal of Biomedical Science. 25, 1, 28.

Research output: Contribution to journalArticle

4 Citations (Scopus)

The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells

Tu, H. J., Lin, Y. J., Chao, M. W., Sung, T. Y., Wu, Y. W., Chen, Y. Y., Lin, M. H., Liou, J. P., Pan, S. L. & Yang, C. R., Dec 29 2018, In : Clinical Epigenetics. 10, 1, 162.

Research output: Contribution to journalArticle

4 Citations (Scopus)

The novel histone de acetylase 6 inhibitor, MPT0G211, ameliorates tau phosphorylation and cognitive deficits in an Alzheimer's disease model article

Fan, S. J., Huang, F. I., Liou, J. P. & Yang, C. R., Jun 1 2018, In : Cell Death and Disease. 9, 6, 655.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Upregulation of Znf179 acetylation by SAHA protects cells against oxidative stress

Wu, C. C., Lee, P. T., Kao, T. J., Chou, S. Y., Su, R. Y., Lee, Y. C., Yeh, S. H., Liou, J. P., Hsu, T. I., Su, T. P., Chuang, C. K., Chang, W. C. & Chuang, J. Y., Oct 1 2018, In : Redox Biology. 19, p. 74-80 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2017

1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma

Liu, Y. M., HuangFu, W. C., Huang, H. L., Wu, W. C., Chen, Y. L., Yen, Y., Huang, H. L., Nien, C. Y., Lai, M. J., Pan, S. L. & Liou, J. P., Nov 10 2017, In : European Journal of Medicinal Chemistry. 140, p. 84-91 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity

Lee, H-Y., Lee, J. F., Kumar, S., Wu, Y. W., HuangFu, W-C., Lai, M-J., Li, Y-H., Huang, H. L., Kuo, F. C., Hsiao, C. J., Cheng, C. C., Yang, C. R. & Liou, J-P., Jan 5 2017, In : European Journal of Medicinal Chemistry. 125, p. 1268-1278 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors in vitro and in vivo

Mehndiratta, S., Wang, R. S., Huang, H. L., Su, C. J., Hsu, C. M., Wu, Y. W., Pan, S. L. & Liou, J. P., Jul 7 2017, In : European Journal of Medicinal Chemistry. 134, p. 13-23 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells

Chao, M. W., Huang, H. L., HuangFu, W. C., Hsu, K. C., Liu, Y. M., Wu, Y. W., Lin, C. F., Chen, Y. L., Lai, M. J., Lee, H. Y., Liou, J. P., Teng, C. M. & Yang, C. R., 2017, In : Oncotarget. 8, 17, p. 27772-27785 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo

Huangfu, W. C., Chao, M. W., Cheng, C. C., Wei, Y. C., Wu, Y. W., Liou, J. P., Hsiao, G., Lee, Y. C. & Yang, C. R., Feb 9 2017, In : Scientific Reports. 7, 42291.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Erratum to: A novel tubulin polymerization inhibitor, MPT0B206, downregulates Bcr-Abl expression and induces apoptosis in imatinib-sensitive and imatinib-resistant CML cells

Chen, C. W., Lee, Y. L., Liou, J. P., Liu, Y. H., Liu, C. W., Chen, T. Y. & Huan, H. M., Aug 18 2017, (Accepted/In press) In : Apoptosis. p. 1 1 p.

Research output: Contribution to journalArticle

Hypoxia-induced downregulation of DUSP-2 phosphatase drives colon cancer stemness

Hou, P. C., Li, Y. H., Lin, S. C., Lin, S. C., Lee, J. C., Lin, B. W., Liou, J. P., Chang, J. Y., Kuo, C. C., Liu, Y. M., Sun, H. S. & Tsai, S. J., Aug 15 2017, In : Cancer Research. 77, 16, p. 4305-4316 12 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
7 Citations (Scopus)

Idiopathic pulmonary fibrosis: Current status, recent progress, and emerging targets

Liu, Y. M., Nepali, K. & Liou, J. P., Jan 26 2017, In : Journal of Medicinal Chemistry. 60, 2, p. 527-553 27 p.

Research output: Contribution to journalReview article

34 Citations (Scopus)
5 Citations (Scopus)

Pharmacokinetics and protein binding of MPT0B292

Tien, Y. E., Li, C. J., Liou, J. P., Chang, J. Y. & Huang, J. D., 2017, (Accepted/In press) In : Biopharmaceutics and Drug Disposition.

Research output: Contribution to journalArticle

Ring-opened tetrahydro-γ-carbolines display cytotoxicity and selectivity with histone deacetylase isoforms

Nepali, K., Lee, H-Y., Lai, M-J., Ojha, R., Wu, T. Y., Wu, G. X., Chen, M-C. & Liou, J-P., Feb 15 2017, In : European Journal of Medicinal Chemistry. 127, p. 115-127 13 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomide resistance in glioblastoma, which is independent of O6-methylguanine-DNA methyltransferase

Chang, K. Y., Hsu, T. I., Hsu, C. C., Tsai, S. Y., Liu, J. J., Chou, S. W., Liu, M. S., Liou, J. P., Ko, C. Y., Chen, K. Y., Hung, J. J., Chang, W. C., Chuang, C. K., Kao, T. J. & Chuang, J. Y., Oct 1 2017, In : Redox Biology. 13, p. 655-664 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
3 Citations (Scopus)
2016

2-(Phenylsulfonyl)quinoline N-hydroxyacrylamides as potent anticancer agents inhibiting histone deacetylase

Lee, H. Y., Chang, C. Y., Su, C. J., Huang, H. L., Mehndiratta, S., Chao, Y. H., Hsu, C. M., Kumar, S., Sung, T. Y., Huang, Y. Z., Li, Y. H., Yang, C. R. & Liou, J. P., Oct 21 2016, In : European Journal of Medicinal Chemistry. 122, p. 92-101 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

A novel tubulin polymerization inhibitor, MPT0B206, downregulates Bcr-Abl expression and induces apoptosis in imatinib-sensitive and imatinib-resistant CML cells

Chen, C. W., Lee, Y. L., Liou, J. P., Liu, Y. H., Liu, C. W., Chen, T. Y. & Huang, H. M., Sep 1 2016, In : Apoptosis. 21, 9, p. 1008-1018 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Early investigational tubulin inhibitors as novel cancer therapeutics

Nepali, K., Ojha, R., Lee, H. Y. & Liou, J. P., Aug 2 2016, In : Expert Opinion on Investigational Drugs. 25, 8, p. 917-936 20 p.

Research output: Contribution to journalReview article

15 Citations (Scopus)

Indole-3-ethylsulfamoylphenylacrylamides with potent anti-proliferative and anti-angiogenic activities

Mehndiratta, S., Pan, S. L., Kumar, S. & Liou, J. P., Jul 1 2016, In : Anti-Cancer Agents in Medicinal Chemistry. 16, 7, p. 907-913 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

LTP-1, a novel antimitotic agent and Stat3 inhibitor, inhibits human pancreatic carcinomas in vitro and in vivo

Huang, H. L., Chao, M. W., Chen, C. C., Cheng, C. C., Chen, M. C., Lin, C. F., Liou, J. P., Teng, C. M. & Pan, S. L., Jun 9 2016, In : Scientific Reports. 6, 27794.

Research output: Contribution to journalArticle

5 Citations (Scopus)

MPT0B098, a microtubule inhibitor, suppresses JAK2/STAT3 signaling pathway through modulation of SOCS3 stability in oral squamous cell carcinoma

Peng, H. Y., Cheng, Y. C., Hsu, Y. M., Wu, G. H., Kuo, C. C., Liou, J. P., Chang, J. Y., Jin, S. L. C. & Shiah, S. G., Jul 1 2016, In : PLoS One. 11, 7, e0158440.

Research output: Contribution to journalArticle

13 Citations (Scopus)
5 Citations (Scopus)
5 Citations (Scopus)

Novel histone deacetylase inhibitor MPT0G009 induces cell apoptosis and synergistic anticancer activity with tumor necrosis factor-related apoptosis-inducing ligand against human hepatocellular carcinoma

Chen, M-C., Huang, H-H., Lai, C-Y., Lin, Y-J., Liou, J-P., Lai, M-J., Li, Y-H., Teng, C-M. & Yang, C-R., Jan 5 2016, In : Oncotarget. 7, 1, p. 402-17 16 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Suberoylanilide hydroxamic acid represses glioma stem-like cells

Hsu, C. C., Chang, W-C., Hsu, T-I., Liu, J. J., Yeh, S. H., Wang, J-Y., Liou, J-P., Ko, C-Y., Chang, K. Y. & Chuang, J-Y., Nov 18 2016, In : Journal of Biomedical Science. 23, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Total Synthesis of Denbinobin

Lee, H. Y., Kumar, S., Lin, T. C. & Liou, J. P., Apr 22 2016, In : Journal of Natural Products. 79, 4, p. 1170-1173 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
10 Citations (Scopus)
2015
14 Citations (Scopus)

2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition

Nepali, K., Kumar, S., Huang, H. L., Kuo, F. C., Lee, C. H., Kuo, C. C., Yeh, T. K., Li, Y. H., Chang, J. Y., Liou, J. P. & Lee, H. Y., 2015, In : Organic and Biomolecular Chemistry. 14, 2, p. 716-723 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Anticancer activity of MPT0G157, a derivative of indolylbenzenesulfonamide, inhibits tumor growth and angiogenesis

Huang, Y. C., Huang, F. I., Mehndiratta, S., Lai, S. C., Liou, J. P. & Yang, C. R., 2015, In : Oncotarget. 6, 21, p. 18590-18601 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)