Ph.D Program in Biotechnology Research and Development

Research Output 1992 2020

2020

A cost-effectiveness analysis of trastuzumab-containing treatment sequences for HER-2 positive metastatic breast cancer patients in Taiwan

Diaby, V., Alqhtani, H., van Boemmel-Wegmann, S., Wang, C. Y., Ali, A. A., Balkrishnan, R., Ko, Y., Palacio, S. & de Lima Lopes, G., Feb 1 2020, In : Breast. 49, p. 141-148 8 p.

Research output: Contribution to journalArticle

Open Access
docetaxel
Taiwan
Cost-Benefit Analysis
Breast Neoplasms
National Health Programs

An assessment of the psychometric properties of the Chinese version of the Gout Impact Scale

Pao, C. H. & Ko, Y., Jan 2 2020, In : Current Medical Research and Opinion. 36, 1, p. 17-21 5 p.

Research output: Contribution to journalArticle

Gout
Psychometrics

Aza-PBHA, a potent histone deacetylase inhibitor, inhibits human gastric-cancer cell migration via PKCα-mediated AHR-HDAC interactions

Tsai, C. H., Li, C. H., Liao, P. L., Chang, Y. W., Cheng, Y. W. & Kang, J. J., Feb 2020, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1867, 2, 118564.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Histone Deacetylase Inhibitors
Histone Deacetylases
Stomach Neoplasms
Cell Movement

Dramatically enhanced mechanical properties of diamond-like carbon films on polymer substrate for flexible display devices via argon plasma pretreatment

Lee, J. A., Lin, C. R., Pan, P. C., Liu, C. W. & Sun, A. Y. T., Jan 15 2020, In : Chemical Physics. 529, 110551.

Research output: Contribution to journalArticle

Flexible displays
Diamond like carbon films
Argon
argon plasma
display devices

Mammalian target of rapamycin and p70S6K mediate thrombin-induced nuclear factor-κB activation and IL-8/CXCL8 release in human lung epithelial cells

Lin, C. H., Shih, C. H., Jiang, C. P., Wen, H. C., Cheng, W. H. & Chen, B. C., Feb 5 2020, In : European Journal of Pharmacology. 868, 172879.

Research output: Contribution to journalArticle

Complement Factor B
Sirolimus
Interleukin-8
Thrombin
Phosphotransferases
1 Citation (Scopus)

N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression

Mehndiratta, S., Lin, M. H., Wu, Y. W., Chen, C. H., Wu, T. Y., Chuang, K. H., Chao, M. W., Chen, Y. Y., Pan, S. L., Chen, M. C. & Liou, J. P., Jan 1 2020, In : European Journal of Medicinal Chemistry. 185, p. 111725 111725.

Research output: Contribution to journalArticle

Anilides
HSP90 Heat-Shock Proteins
Histone Deacetylase Inhibitors
Histone Deacetylases
Down-Regulation

Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment

Kaur, N., Fang, Y. C., Lee, H. Y., Singh, A., Nepali, K., Lin, M. H., Yeh, T. K., Lai, M. J., Chan, L., Tu, Y. K., Banerjee, S., Hu, C. J. & Liou, J. P., Feb 1 2020, In : European Journal of Medicinal Chemistry. 187, 111915.

Research output: Contribution to journalArticle

Azepines
Histone Deacetylase Inhibitors
Blood Vessels
Acetylation
Acrylamide

Synthesis and biological evaluation of 2-quinolineacrylamides

Wang, S. W., Lin, M. H., Hsu, F. C., Chen, M. C., Liou, J. P., Liu, Y. T., Chen, S. S. & Lee, H. Y., Feb 1 2020, In : Bioorganic and Medicinal Chemistry. 28, 3, 115250.

Research output: Contribution to journalArticle

Protein Isoforms
HCT116 Cells
Ether
Western Blotting
A549 Cells
2019
5 Citations (Scopus)

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

Benzamides
Histone Deacetylases
Tubulin
Heterografts
Inhibitory Concentration 50
Curcumin
Endothelin-1
Fibroblasts
Thrombin
Phosphotransferases
1 Citation (Scopus)

Alteration in iron efflux affects male sex hormone testosterone biosynthesis in a diet-induced obese rat model

Kurniawan, A. L., Lee, Y. C., Shih, C. K., Hsieh, R. H., Chen, S. H. & Chang, J. S., Jul 17 2019, In : Food and Function. 10, 7, p. 4113-4123 11 p.

Research output: Contribution to journalArticle

sex hormones
Gonadal Steroid Hormones
testosterone
Testosterone
Iron

Alternative splicing in human cancer cells is modulated by the amiloride derivative 3,5-diamino-6-chloro-N-(N-(2,6-dichlorobenzoyl)carbamimidoyl)pyrazine-2-carboxide

Lee, C. C., Chang, W. H., Chang, Y. S., Yang, J. M., Chang, C. S., Hsu, K. C., Chen, Y. T., Liu, T. Y., Chen, Y. C., Lin, S. Y., Wu, Y. C. & Chang, J. G., Jan 1 2019, In : Molecular Oncology. 13, 8, p. 1744-1762 19 p.

Research output: Contribution to journalArticle

Open Access
Pyrazines
Amiloride
Alternative Splicing
Neoplasms
RNA Sequence Analysis
1 Citation (Scopus)
Growth Inhibitors
Amides
Prostatic Neoplasms
Cells
Lead compounds
Social Welfare
Taiwan
Pharmacists
Pharmaceutical Services
Community Pharmacy Services

A novel preventive mechanism of gentamicin-induced nephrotoxicity by atorvastatin

Lee, M. C., Cheng, K. J., Chen, S. M., Li, Y. C., Imai, K., Lee, C. M. & Lee, J. A., Nov 1 2019, In : Biomedical Chromatography. 33, 11, p. e4639 e4639.

Research output: Contribution to journalArticle

Gentamicins
Cathepsins
Metabolism
Proteomics
Macrophage Migration-Inhibitory Factors
Single-Chain Antibodies
Epitopes
Escherichia coli
Amino Acids
OMPA outer membrane proteins
5 Citations (Scopus)

Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivo

Hsieh, Y. L., Tu, H. J., Pan, S. L., Liou, J. P. & Yang, C. R., Jun 1 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 6, p. 992-1003 12 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Histone Deacetylase Inhibitors
Breast Neoplasms
Histone Deacetylases
Acetylation
4 Citations (Scopus)

Applications of cyclic peptide nanotubes (cPNTs)

Hsieh, W. H. & Liaw, J., Jan 2019, (Accepted/In press) In : Journal of Food and Drug Analysis. 27, 1

Research output: Contribution to journalArticle

Peptide Nanotubes
nanotubes
cyclic peptides
Cyclic Peptides
drugs
1 Citation (Scopus)

Argon plasma surface modified porcine bone substitute improved osteoblast-like cell behavior

Choy, C. S., Salamanca, E., Lin, P. Y., Huang, H. M., Teng, N. C., Pan, Y. H. & Chang, W. J., Jan 1 2019, In : Coatings. 9, 2, p. 9-134 126 p.

Research output: Contribution to journalArticle

Open Access
Bone Substitutes
osteoblasts
Argon
Osteoblasts
argon plasma

Association of endothelin genetic variants and hospitalized infection complications in end-stage renal disease (ESRD) patients

Kao, C. C., Cheng, S. Y., Wang, Y. J., Chien, S. C., Hsu, Y. W., Wu, M. Y., Lu, H. F., Nam, S., Sun, T., Wu, M. S. & Chang, W. C., Jun 5 2019, In : BMC Nephrology. 20, 1, p. 203 203.

Research output: Contribution to journalArticle

Open Access
Endothelins
Chronic Kidney Failure
Bacteremia
Infection
Single Nucleotide Polymorphism
Open Access
Cyclin D
Cell Proliferation
Medicine
Internal Medicine
Taiwan

Biocompatibility and osteogenic capacity of Mg-Zn-Ca Bulk metallic glass for rabbit tendon-bone interference fixation

Wong, C. C., Wong, P. C., Tsai, P. H., Jang, J. S. C., Cheng, C. K., Chen, H. H. & Chen, C. H., May 3 2019, In : International Journal of Molecular Sciences. 20, 9, 2191.

Research output: Contribution to journalArticle

Open Access
tendons
Tendons
rabbits
Metallic glass
biocompatibility

Body mass index growth trajectories, early pubertal maturation, and short stature

Fan, H. Y., Lee, Y. L., Hsieh, R. H., Yang, C. & Chen, Y. C., Jan 1 2019, (Accepted/In press) In : Pediatric Research.

Research output: Contribution to journalArticle

Body Mass Index
Puberty
Growth
Sleep
Fats

Characterization of T-Cell Receptor Repertoire in Patients with Rheumatoid Arthritis Receiving Biologic Therapies

Chang, C. M., Hsu, Y. W., Wong, H. S. C., Wei, J. C. C., Liu, X., Liao, H. T. & Chang, W. C., Jan 1 2019, In : Disease Markers. 2019, 1 p.

Research output: Contribution to journalArticle

Open Access
Biological Therapy
Antirheumatic Agents
T-Cell Antigen Receptor
Antigen Receptors, T-Cell, alpha-beta
Rheumatoid Arthritis
3 Citations (Scopus)

Chloramphenicol induces autophagy and inhibits the hypoxia inducible factor-1 alpha pathway in non-small cell lung cancer cells

Hsu, H. L., Liao, P. L., Cheng, Y. W., Huang, S. H., Wu, C. H., Li, C. H. & Kang, J. J., Jan 1 2019, In : International Journal of Molecular Sciences. 20, 1, 157.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
hypoxia
Autophagy
Chloramphenicol
Non-Small Cell Lung Carcinoma
2 Citations (Scopus)

Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status

Chao, M. W., Chang, L. H., Tu, H. J., Chang, C. D., Lai, M. J., Chen, Y. Y., Liou, J. P., Teng, C. M. & Pan, S. L., May 29 2019, In : Clinical Epigenetics. 11, 1, 85.

Research output: Contribution to journalArticle

Open Access
Histone Deacetylase Inhibitors
Mitogen-Activated Protein Kinase Kinases
Pancreatic Neoplasms
Epidermal Growth Factor Receptor
Heterografts

Constructing a bilingual website with validated database for Herb and Western medicine interactions using Ginseng, Ginkgo and Dong Quai as examples

Wu, C. S., Chen, Y. H., Chen, C. L., Chien, S. K., Syifa, N., Hung, Y. C., Cheng, K. J., Hu, S. C., Lo, P. T., Lin, S. Y. & Wu, T. H., Nov 27 2019, In : BMC Complementary and Alternative Medicine. 19, 1, 335.

Research output: Contribution to journalArticle

Open Access
Herb-Drug Interactions
Ginkgo biloba
Panax
Medicine
Databases

Correction: Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and akt activation in non-small cell lung cancer cells (Oncotarget (2017) 8 (28342–28358) DOI: 10.18632/oncotarget.16058)

Tsai, M. H., Liu, J. F., Chiang, Y. C., Hu, S. C. S., Hsu, L. F., Lin, Y. C., Lin, Z. C., Lee, H. C., Chen, M. C., Huang, C. L. & Lee, C. W., May 1 2019, In : Oncotarget. 10, 36, 1 p.

Research output: Contribution to journalArticle

Open Access
Taiwan
Non-Small Cell Lung Carcinoma
Rehabilitation
Apoptosis
artocarpin flavonoid
Open Access
Aquaporin 1
Caveolin 1
Brain Edema
Gold
Nanoparticles

Costs and Length of Stay of Hospitalizations due to Diabetes-Related Complications

Cheng, S. W., Wang, C. Y. & Ko, Y., Jan 1 2019, In : Journal of Diabetes Research. 2019, 2363292.

Research output: Contribution to journalArticle

Open Access
Diabetes Complications
Length of Stay
Diabetes Mellitus
Hospitalization
Costs and Cost Analysis
Open Access
hormones
Nerve Growth Factors
releasing
Endometriosis
Gonadotropin-Releasing Hormone
1 Citation (Scopus)

Dental Pulp Stem Cell Transplantation with 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside Accelerates Alveolar Bone Regeneration in Rats

Lin, C. Y., Kuo, P. J., Chin, Y. T., Weng, I. T., Lee, H. W., Huang, H. M., Lin, H. Y., Hsiung, C. N., Chan, Y. H. & Lee, S. Y., Apr 1 2019, In : Journal of Endodontics. 45, 4, p. 435-441 7 p.

Research output: Contribution to journalArticle

Dental Pulp
Bone Regeneration
Stem Cell Transplantation
Stem Cells
Osteogenesis

Development of an inflammatory tissue-selective chimeric TNF receptor

Lee, C. J., Wang, C. C., Chen, M., Chuang, K. H., Cheng, T. L., Jian, T. Y., Wang, Y. M., Huang, T. H., Liao, K. W. & Tzou, S. C., Jan 1 2019, In : Cytokine. 113, p. 340-346 7 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptors
Matrix Metalloproteinases
Tissue
Substrates
Binding Sites

Down-regulation of aryl hydrocarbon receptor intensifies carcinogen-induced retinal lesion via SOCS3-STAT3 signaling

Tsai, C. H., Lee, Y., Li, C. H., Cheng, Y. W. & Kang, J. J., Jan 1 2019, (Accepted/In press) In : Cell Biology and Toxicology.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
STAT3 Transcription Factor
Carcinogens
Down-Regulation
Cytokines
Embryonal Carcinoma Stem Cells
Neural Stem Cells
Zinc Fingers
Transcription
Zinc

Efficacy of azatyrosine-phenylbutyric hydroxamides, a histone deacetylase inhibitor, on chemotherapy-induced gastrointestinal mucositis

Liao, P. L., Huang, S. H., Hung, C. H., Huang, W. K., Tsai, C. H., Kang, J. J., Wang, H. P. & Cheng, Y. W., Jan 1 2019, In : International Journal of Molecular Sciences. 20, 2, 249.

Research output: Contribution to journalArticle

monocytes
interleukins
Mucositis
Histone Deacetylase Inhibitors
Chemotherapy
1 Citation (Scopus)

Electrospun polylactic acid (PLLA) microtube array membrane (MTAM)-An advanced substrate for anticancer drug screening

Tseng, C. H., Huang, W. T., Chew, C. H., Lai, J. K., Tu, S. H., Wei, P. L., Lee, K. Y., Lai, G. M. & Chen, C. C., Feb 14 2019, In : Materials. 12, 4, 569.

Research output: Contribution to journalArticle

Open Access
Assays
Screening
Membranes
Cells
Acids
1 Citation (Scopus)

Elucidation of the Effects of Si-Wu Tang on Menstrual Disorder Patterns through Activation of Aromatase and Antioxidation

Huang, G. C., Tsai, Y. Z., Lee, C. J., Chang, H. Y. & Wang, C. C., Mar 6 2019, In : Evidence-based Complementary and Alternative Medicine. 2019, p. 4761651 8 p., 4761651.

Research output: Contribution to journalArticle

Open Access
Rehmannia
Aromatase
ferulic acid
Polyphenols
Estradiol

Endocytosis-dependent lysosomal degradation of Src induced by protease-activated receptor 1

Tsai, C. C., Kuo, F. T., Lee, S. B., Chang, Y. T. & Fu, H. W., Mar 1 2019, In : FEBS Letters. 593, 5, p. 504-517 14 p.

Research output: Contribution to journalArticle

PAR-1 Receptor
Endocytosis
Degradation
Chemical activation
Dynamins

ESTABLISH A MECHANICAL DAMPING MODEL FOR EVALUATING THE SURROUNDING SOFT TISSUE OF DENTAL IMPLANT

Huang, C. H., Fan, K. H., Wu, C. Z. & Huang, H. M., Mar 1 2019, In : Journal of Mechanics in Medicine and Biology. 19, 2, 1940023.

Research output: Contribution to journalArticle

Dental prostheses
Damping
Tissue
Bone
Epoxy resins

Evaluation of a technological image-based dietary assessment tool for children during pubertal growth: A pilot study

Wang, J. S., Hsieh, R. H., Tung, Y. T., Chen, Y. C., Chen, Y. H. & Yang, C., Oct 20 2019, In : Nutrients. 11, 10, 2527.

Research output: Contribution to journalArticle

Open Access
Micronutrients
dietary minerals
Growth
Nutritionists
food records
2 Citations (Scopus)

Expression of AHI1 Rescues Amyloidogenic Pathology in Alzheimer’s Disease Model Cells

Ting, L. L., Lu, H. T., Yen, S. F., Ngo, T. H., Tu, F. Y., Tsai, I. S., Tsai, Y. H., Chang, F. Y., Li, X. J., Li, S., Lee, C. K., Kao, S. H., Kuo, Y. M. & Lin, Y. F., Nov 1 2019, In : Molecular Neurobiology. 56, 11, p. 7572-7582 11 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Alzheimer Disease
Pathology
Amyloid
Protein C
2 Citations (Scopus)

Ganglioside Hp-s1 Analogue Inhibits Amyloidogenic Toxicity in Alzheimer's Disease Model Cells

Tsai, Y. F., Yang, D. J., Ngo, T. H., Shih, C. H., Wu, Y. F., Lee, C. K., Phraekanjanavichid, V., Yen, S. F., Kao, S. H., Lee, H. M., Huang, V. S., Shieh, J. C. C. & Lin, Y. F., Jan 16 2019, In : ACS Chemical Neuroscience. 10, 1, p. 528-536 9 p.

Research output: Contribution to journalArticle

Gangliosides
Amyloid beta-Protein Precursor
Toxicity
Alzheimer Disease
Cells
1 Citation (Scopus)

Gene-Embedded Nanostructural Biotic-Abiotic Optoelectrode Arrays Applied for Synchronous Brain Optogenetics and Neural Signal Recording

Huang, W. C., Chi, H. S., Lee, Y. C., Lo, Y. C., Liu, T. C., Chiang, M. Y., Chen, H. Y., Li, S. J., Chen, Y. Y. & Chen, S. Y., Mar 27 2019, In : ACS Applied Materials and Interfaces. 11, 12, p. 11270-11282 13 p.

Research output: Contribution to journalArticle

Brain
Genes
Polyethyleneimine
Neurotensin
Plasmids

Genetic loci determining total immunoglobulin E levels from birth through adulthood

Yao, T. C., Chung, R. H., Lin, C. Y., Tsai, P. C., Chang, W. C., Yeh, K. W., Tsai, M. H., Liao, S. L., Hua, M. C., Lai, S. H., Chen, L. C., Chang, S. W., Yu, Y. W., Hsu, J. Y., Chang, S. C., Cheng, W. C., Hu, D., Hong, X., Burchard, E. G., Wang, X. & 3 others, Tzeng, J. Y., Tsai, H. J. & Huang, J. L., Mar 1 2019, In : Allergy: European Journal of Allergy and Clinical Immunology. 74, 3, p. 621-625 5 p.

Research output: Contribution to journalLetter

Genetic Loci
Immunoglobulin E
Parturition

Genomic interrogation of familial short stature contributes to the discovery of the pathophysiological mechanisms and pharmaceutical drug repositioning

Wong, H. S. C., Lin, Y. J., Lu, H. F., Liao, W. L., Chen, C. H., Wu, J. Y., Chang, W. C. & Tsai, F. J., Nov 7 2019, In : Journal of Biomedical Science. 26, 1, 91.

Research output: Contribution to journalArticle

Open Access
Drug Repositioning
Genes
Pharmaceutical Preparations
Endocrine System
Genetic Loci
1 Citation (Scopus)

Glycemia Lowering Effect of an Aqueous Extract of Hedychium coronarium Leaves in Diabetic Rodent Models

Tse, L. S., Liao, P. L., Tsai, C. H., Li, C. H., Liao, J. W., Kang, J. J. & Cheng, Y. W., Mar 14 2019, In : Nutrients. 11, 3

Research output: Contribution to journalArticle

Open Access
Hedychium coronarium
Zingiberaceae
Type 2 Diabetes Mellitus
blood glucose
Rodentia
3 Citations (Scopus)

Gonadotropin-releasing hormone agonist induces downregulation of tensin 1 in women with endometriosis

Rahmawati, E., Yang, W. C. V., Lei, Y. P., Maurya, P. K., Chen, H. W. & Tzeng, C. R., Feb 1 2019, In : Acta Obstetricia et Gynecologica Scandinavica. 98, 2, p. 222-231 10 p.

Research output: Contribution to journalArticle

Endometriosis
Gonadotropin-Releasing Hormone
Down-Regulation
Serum
Cell Movement
1 Citation (Scopus)

HDAC8 inhibitor WK2-16 therapeutically targets lipopolysaccharide-induced mouse model of neuroinflammation and microglial activation

Lin, F. L., Yen, J. L., Kuo, Y. C., Kang, J. J., Cheng, Y. W., Huang, W. J. & Hsiao, G., Jan 2 2019, In : International Journal of Molecular Sciences. 20, 2, p. 410 410.

Research output: Contribution to journalArticle

Neuroglia
inhibitors
mice
Lipopolysaccharides
Chemical activation

Hirsutanol A attenuates lipopolysaccharide-mediated matrix metalloproteinase 9 expression and cytokines production and improves endotoxemia-induced acute sickness behavior and acute lung injury

Jan, J. S., Yang, C. H., Wang, M. H., Lin, F. L., Yen, J. L., Hsieh, I., Khotimchenko, M., Lee, T. H. & Hsiao, G., Jun 17 2019, In : Marine Drugs. 17, 6, 360.

Research output: Contribution to journalArticle

Open Access
Illness Behavior
Endotoxemia
Acute Lung Injury
Matrix Metalloproteinase 9
Lipopolysaccharides