Ph.D. Program for Cancer Molecular Biology and Drug Discovery

  • No. 250 Wu-Xing Street

    11031 Taipei

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2013

Molecular mechanisms of actions of formulations of the thyroid hormone analogue, tetrac, on the inflammatory response

Davis, P. J., Glinsky, G. V., Lin, H. Y., Incerpi, S., Davis, F. B., Mousa, S. A., Tang, H. Y., Hercbergs, A. & Luidens, M. K., 2013, In : Endocrine Research. 38, 2, p. 112-118 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Moscatilin inhibits migration and metastasis of human breast cancer MDA-MB-231 cells through inhibition of Akt and Twist signaling pathway

Pai, H. C., Chang, L. H., Peng, C. Y., Chang, Y. L., Chen, C. C., Shen, C. C., Teng, C. M. & Pan, S. L., Mar 2013, In : Journal of Molecular Medicine. 91, 3, p. 347-356 10 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Nuclear monomeric integrin αv in cancer cells is a coactivator regulated by thyroid hormone

Lin, H. Y., Su, Y. F., Hsieh, M. T., Lin, S., Meng, R., London, D., Lin, C., Tang, H. Y., Hwang, J., Davis, F. B., Mousa, S. A. & Davis, P. J., Aug 2013, In : FASEB Journal. 27, 8, p. 3209-3216 8 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Optimization of global DNA methylation measurement by LC-MS/MS and its application in lung cancer patients

Hu, C. W., Lee, H., Chen, J. L., Li, Y. J. & Chao, M. R., 2013, In : Analytical and Bioanalytical Chemistry. 405, 27, p. 8859-8869 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Pin1 acts as a negative regulator of the G2/M transition by interacting with the Aurora-A-Bora complex

Lee, Y. C., Que, J., Chen, Y. C., Lin, J. T., Liou, Y. C., Liao, P. C., Liu, Y. P., Lee, K. H., Lin, L. C., Hsiao, M., Hung, L. Y., Huang, C. Y. & Lu, P. J., Nov 1 2013, In : Journal of Cell Science. 126, 21, p. 4862-4872 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
20 Citations (Scopus)

Proteomic and functional analysis of zebrafish after administration of antimicrobial peptide epinecidin-1

Huang, T. C. & Chen, J. Y., Feb 2013, In : Fish and Shellfish Immunology. 34, 2, p. 593-598 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Pulmonary CYP2A13 levels are associated with early occurrence of lung cancer-Its implication in mutagenesis of non-small cell lung carcinoma

Chiang, H. C., Lee, H., Chao, H. R., Chiou, Y. H. & Tsou, T. C., Oct 2013, In : Cancer Epidemiology. 37, 5, p. 653-659 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Radiation-induced senescence in securin-deficient cancer cells promotes cell invasion involving the IL-6/STAT3 and PDGF-BB/PDGFR pathways

Yu, Y. C., Yang, P. M., Chuah, Q. Y., Huang, Y. H., Peng, C. W., Lee, Y. J. & Chiu, S. J., 2013, In : Scientific Reports. 3, 1675.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Randomised clinical trial: Comparison of two everolimus dosing schedules in patients with advanced hepatocellular carcinoma

Shiah, H. S., Chen, C. Y., Dai, C. Y., Hsiao, C. F., Lin, Y. J., Su, W. C., Chang, J. Y., Whang-Peng, J., Lin, P. W., Huang, J. D. & Chen, L. T., Jan 2013, In : Alimentary Pharmacology and Therapeutics. 37, 1, p. 62-73 12 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Response of Human Pancreatic Cancer Cell Xenografts to Tetraiodothyroacetic Acid Nanoparticles

Yalcin, M., Lin, H. Y., Sudha, T., Bharali, D. J., Meng, R., Tang, H. Y., Davis, F. B., Stain, S. C., Davis, P. J. & Mousa, S. A., 2013, In : Hormones and Cancer. 4, 3, p. 176-185 10 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Ribonucleotide Reductase Large Subunit M1 Predicts Poor Survival Due to Modulation of Proliferative and Invasive Ability of Gastric Cancer

Wang, Q., Liu, X., Zhou, J., Huang, Y., Zhang, S., Shen, J., Loera, S., Yuan, X., Chen, W., Jin, M., Shibata, S., Liu, Y., Chu, P., Wang, L. & Yen, Y., Jul 29 2013, In : PLoS One. 8, 7, e70191.

Research output: Contribution to journalArticle

13 Citations (Scopus)

The chromatin modification by SUMO-2/3 but not SUMO-1 prevents the epigenetic activation of key immune-related genes during Kaposi's sarcoma associated herpesvirus reactivation

Chang, P. C., Cheng, C. Y., Campbell, M., Yang, Y. C., Hsu, H. W., Chang, T. Y., Chu, C. H., Lee, Y. W., Hung, C. L., Lai, S. M., Tepper, C. G., Hsieh, W. P., Wang, H. W., Tang, C. Y., Wang, W. C. & Kung, H. J., Nov 23 2013, In : BMC Genomics. 14, 1, 824.

Research output: Contribution to journalArticle

20 Citations (Scopus)

The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells

Chen, M. C., Chen, C. H., Wang, J. C., Tsai, A. C., Liou, J. P., Pan, S. L. & Teng, C. M., Sep 2013, In : Cell Death and Disease. 4, 9, e810.

Research output: Contribution to journalArticle

51 Citations (Scopus)

The prognostic significance of APC gene mutation and miR-21 expression in advanced-stage colorectal cancer

Chen, T. H., Chang, S. W., Huang, C. C., Wang, K. L., Yeh, K. T., Liu, C. N., Lee, H., Lin, C. C. & Cheng, Y. W., Nov 2013, In : Colorectal Disease. 15, 11, p. 1367-1374 8 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

The role of interleukin-10 in the progression of human papillomavirus-associated lung carcinoma

Sung, W. W. & Lee, H., 2013, In : OncoImmunology. 2, 9, e25854.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Time Trend of Multiple Myeloma and Associated Secondary Primary Malignancies in Asian Patients: A Taiwan Population-Based Study

Tzeng, H. E., Lin, C. L., Tsai, C. H., Tang, C. H., Hwang, W. L., Cheng, Y. W., Sung, F. C. & Chung, C. J., Jul 2 2013, In : PLoS ONE. 8, 7, e68041.

Research output: Contribution to journalArticle

17 Citations (Scopus)

TW01001, a novel piperazinedione compound, induces mitotic arrest and autophagy in non-small cell lung cancer A549 cells

Chen, M. C., Chen, C. H., Liu, Y. N., Wang, H. P., Pan, S. L. & Teng, C. M., Aug 19 2013, In : Cancer Letters. 336, 2, p. 370-378 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Upregulation of endocan by epstein-barr virus latent membrane protein 1 and its clinical significance in nasopharyngeal Carcinoma

Yu, P. H., Chou, S. F., Chen, C. L., Hung, H., Lai, C. Y., Yang, P. M., Jeng, Y. M., Liaw, S. F., Kuo, H. H., Hsu, H. C., Chen, J. Y. & Wang, W. B., Dec 5 2013, In : PLoS ONE. 8, 12, e82254.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Usefulness of offline fractional exhaled nitric oxide measurements in the elderly asthmatic patients

Hsu, J. Y., Huang, W. C., Huang, P. L., Cheng, Y. W. & Chou, M. C., 2013, In : Allergy and Asthma Proceedings. 35, 5, p. 434-438 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress

Yang, P. M., Lin, Y. T., Shun, C. T., Lin, S. H., Wei, T. T., Chuang, S. H., Wu, M. S. & Chen, C. C., Nov 14 2013, In : Scientific Reports. 3, 3219.

Research output: Contribution to journalArticle

47 Citations (Scopus)
2012

Chemotherapeutics and radiation stimulate MHC class i expression through elevated interferon-beta signaling in breast cancer cells

Wan, S., Pestka, S., Jubin, R. G., Lyu, Y. L., Tsai, Y. C. & Liu, L. F., Mar 1 2012, In : PLoS ONE. 7, 3, e32542.

Research output: Contribution to journalArticle

111 Citations (Scopus)

CYP1A1 protein activity is associated with allelic variation in pterygium tissues and cells

Peng, M. L., Tsai, Y. Y., Chiang, C. C., Huang, Y. C., Chou, M. C., Yeh, K. T., Lee, H. & Cheng, Y. W., 2012, In : Molecular Vision. 18, p. 1937-1943 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

De novo sequencing of circulating miRNAs identifies novel markers predicting clinical outcome of locally advanced breast cancer

Wu, X., Somlo, G., Yu, Y., Palomares, M. R., Li, A. X., Zhou, W., Chow, A., Yen, Y., Rossi, J. J., Gao, H., Wang, J., Yuan, Y. C., Frankel, P., Li, S., Ashing-Giwa, K. T., Sun, G., Wang, Y., Smith, R., Robinson, K., Ren, X. & 1 others, Wang, S. E., Mar 8 2012, In : Journal of Translational Medicine. 10, 1, 42.

Research output: Contribution to journalArticle

150 Citations (Scopus)

Differential Impact of IL-10 Expression on Survival and Relapse between HPV16-Positive and -Negative Oral Squamous Cell Carcinomas

Chuang, C. Y., Sung, W. W., Wang, L., Lin, W. L., Yeh, K. T., Su, M. C., Hsin, C. H., Lee, S. Y., Wu, B. C., Cheng, Y. W. & Lee, H., Oct 31 2012, In : PLoS One. 7, 10, e47541.

Research output: Contribution to journalArticle

19 Citations (Scopus)

DYZ-2-90, a Novel Neo-tanshinlactone Ring-Opened Compound, Induces ERK-Mediated Mitotic Arrest and Subsequent Apoptosis by Activating JNK in Human Colorectal Cancer Cells

Wang, L. T., Pan, S. L., Chen, T. H., Dong, Y., Lee, K. H. & Teng, C. M., Jul 23 2012, In : ChemBioChem. 13, 11, p. 1663-1672 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Ectopic ATP synthase blockade suppresses lung adenocarcinoma growth by activating the unfolded protein response

Chang, H. Y., Huang, H. C., Huang, T. C., Yang, P. C., Wang, Y. C. & Juan, H. F., Sep 15 2012, In : Cancer Research. 72, 18, p. 4696-4706 11 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Erratum: Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR (FEBS Letters (2011) 585 (3582-3586))

Huang, T. C., Chang, H. Y., Chen, C. Y., Wu, P. Y., Lee, H., Liao, Y. F., Hsu, W. M., Huang, H. C. & Juan, H. F., Jan 2 2012, In : FEBS Letters. 586, 1, p. 107 1 p.

Research output: Contribution to journalArticle

Human papilloma virus 16 E6 oncoprotein associated with p53 inactivation in colorectal cancer

Chen, T. H., Huang, C. C., Yeh, K. T., Chang, S. H., Chang, S. W., Sung, W. W., Cheng, Y. W. & Lee, H., 2012, In : World Journal of Gastroenterology. 18, 30, p. 4051-4058 8 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Integrin-Mediated Actions of Thyroid Hormone Analogues on Tumor Cell Chemosensitivity, Integrin-Growth Factor Receptor Crosstalk and Inflammatory Gene Expression.

Hercbergs, A., Davis, F. B., Lin, H-Y., Luidens, M. K., Meng, R., Ashur-Fabian, O., Mousa, S. A. & Davis, P. J., 2012, In : Cancer and Clinical Oncology . 1, p. 32-40 9 p.

Research output: Contribution to journalArticle

Loss of TIMP-3 promotes tumor invasion via elevated IL-6 production and predicts poor survival and relapse in HPV-infected non-small cell lung cancer

Wu, D. W., Tsai, L. H., Chen, P. M., Lee, M. C., Wang, L., Chen, C. Y., Cheng, Y. W. & Lee, H., Nov 2012, In : American Journal of Pathology. 181, 5, p. 1796-1806 11 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Markers for efficacy of mammalian target of rapamycin inhibitor

Liao, Y. M., Sy, A. & Yen, Y., Oct 2012, In : Anticancer Research. 32, 10, p. 4235-4244 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Phosphorylation of Ubc9 by Cdk1 enhances SUMOylation activity

Su, Y. F., Yang, T., Huang, H., Liu, L. F. & Hwang, J., Apr 3 2012, In : PLoS ONE. 7, 4, e34250.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Physalin F induces cell apoptosis in human renal carcinoma cells by targeting NF-kappaB and generating reactive oxygen species

Wu, S. Y., Leu, Y. L., Chang, Y. L., Wu, T. S., Kuo, P. C., Liao, Y. R., Teng, C. M. & Pan, S. L., Jul 16 2012, In : PLoS ONE. 7, 7, e40727.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Ribonucleotide reductase and non-small cell lung cancer

Hsu, N. Y., Lee, H., Cheng, Y. W. & Yen, Y., Jan 1 2012, In : Chinese Journal of Lung Cancer. 15, 11, p. 619-623 5 p.

Research output: Contribution to journalArticle

RRM2B suppresses activation of the oxidative stress pathway and is Up-regulated by P53 during senescence

Kuo, M. L., Sy, A. J., Xue, L., Chi, M., Michelle, M. T., Yen, T., Chiang, M. I., Chang, L., Chu, P. & Yen, Y., Nov 22 2012, In : Scientific Reports. 2, 822.

Research output: Contribution to journalArticle

22 Citations (Scopus)

The APE1 Asp/Asp genotype and the combination of APE1 Asp/Asp and hOGG1-Cys variants are associated with increased p53 mutation in non-small cell lung cancer

Lin, C. H., Chen, P. M., Cheng, Y. W., Chen, C. Y., Yuan, C. J. & Lee, H., 2012, In : Journal of Epidemiology. 22, 6, p. 537-542 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2011

FZD7 has a critical role in cell proliferation in triple negative breast cancer

Yang, L., Wu, X., Wang, Y., Zhang, K., Wu, J., Yuan, Y. C., Deng, X., Chen, L., Kim, C. C. H., Lau, S., Somlo, G. & Yen, Y., Oct 27 2011, In : Oncogene. 30, 43, p. 4437-4446 10 p.

Research output: Contribution to journalArticle

169 Citations (Scopus)

Pathogen recognition receptor signaling accelerates phosphorylation-dependent degradation of IFNAR1

Qian, J., Zheng, H., HuangFu, W. C., Liu, J., Carbone, C. J., Leu, N. A., Baker, D. P. & Fuchs, S. Y., Jun 2011, In : PLoS Pathogens. 7, 6, e1002065.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR

Huang, T. C., Chang, H. Y., Chen, C. Y., Wu, P. Y., Lee, H., Liao, Y. F., Hsu, W. M., Huang, H. C. & Juan, H. F., Nov 16 2011, In : FEBS Letters. 585, 22, p. 3582-3586 5 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator

Lee, K. H., Hsu, E. C., Guh, J. H., Yang, H. C., Wang, D., Kulp, S. K., Shapiro, C. L. & Chen, C. S., Nov 11 2011, In : Journal of Biological Chemistry. 286, 45, p. 39247-39258 12 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)

The effect of narrow bandwidth infrared radiation on the growth of Escherichia coli

Tsai, S. R., Huang, T. C., Liang, C. M., Chang, H. Y., Chang, Y. T., Huang, H. C., Juan, H. F. & Lee, S. C., Oct 17 2011, In : Applied Physics Letters. 99, 16, 163704.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The inhibition of angiogenesis and tumor growth by denbinobin is associated with the blocking of insulin-like growth factor-1 receptor signaling

Tsai, A. C., Pan, S. L., Lai, C. Y., Wang, C. Y., Chen, C. C., Shen, C. C. & Teng, C. M., Jul 2011, In : Journal of Nutritional Biochemistry. 22, 7, p. 625-633 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Thrombin induces expression of twist and cell motility via the hypoxia-inducible factor-1α translational pathway in colorectal cancer cells

Chang, L. H., Chen, C-H., Huang, D. Y., Pai, H. C., Pan, S. L. & Teng, C. M., Apr 2011, In : Journal of Cellular Physiology. 226, 4, p. 1060-1068 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2010

CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation

Tsai, A. C., Pan, S. L., Sun, H. L., Wang, C. Y., Peng, C. Y., Wang, S. W., Chang, Y. L., Kuo, S. C., Lee, K. H. & Teng, C. M., Feb 19 2010, In : Journal of Biological Chemistry. 285, 8, p. 5497-5506 10 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo

Tsai, A. C., Pan, S. L., Liao, C. H., Guh, J. H., Wang, S. W., Sun, H. L., Liu, Y. N., Chen, C. C., Shen, C. C., Chang, Y. L. & Teng, C. M., Jun 2010, In : Cancer Letters. 292, 2, p. 163-170 8 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

The indazole derivative YD-3 specifically inhibits thrombin-induced angiogenesis in vitro and in vivo

Peng, C. Y., Pan, S. L., Pai, H. C., Tsai, A. C., Guh, J. H., Chang, Y. L., Kuo, S. C., Lee, F. Y. & Teng, C. M., Dec 2010, In : Shock. 34, 6, p. 580-585 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2008

Targeting therapy for breast carcinoma by ATP synthase inhibitor aurovertin b

Huang, T. C., Chang, H. Y., Hsu, C. H., Kuo, W. H., Chang, K. J. & Juan, H. F., Apr 2008, In : Journal of Proteome Research. 7, 4, p. 1433-1444 12 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)
2007

A dominant antigenic epitope on SARS-CoV spike protein identified by an avian single-chain variable fragment (scFv)-expressing phage

Lee, Y. C., Leu, S. J. C., Hung, H. C., Wu, H. H., Huang, I. J., Hsieh, W. S., Chiu, W. T., Hsieh, M. S., Cheng, T. F. & Yang, Y. Y., May 15 2007, In : Veterinary Immunology and Immunopathology. 117, 1-2, p. 75-85 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

An apoptosis-related gene network induced by novel compound-cRGD in human breast cancer cells

Huang, T. C., Huang, H. C., Chang, C. C., Chang, H. Y., Ou, C. H., Hsu, C. H., Chen, S. T. & Juan, H. F., Jul 24 2007, In : FEBS Letters. 581, 18, p. 3517-3522 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)