Ph.D. Program for Cancer Molecular Biology and Drug Discovery

  • No. 250 Wu-Xing Street

    11031 Taipei

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2018

Protective Effect of Melatonin against Oxidative Stress-Induced Apoptosis and Enhanced Autophagy in Human Retinal Pigment Epithelium Cells

Chang, C. C., Huang, T. Y., Chen, H. Y., Huang, T. C., Lin, L. C., Chang, Y. J. & Hsia, S. M., Jan 1 2018, In : Oxidative Medicine and Cellular Longevity. 2018, 9015765.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Radix Paeoniae Rubra stimulates osteoclast differentiation by activation of the NF-ΚB and mitogen-activated protein kinase pathways

Tzeng, H. E., Tsai, C. H., Ho, T. Y., Hsieh, C. T., Chou, S. C., Lee, Y. J., Tsay, G. J., Huang, P. H. & Wu, Y. Y., Apr 23 2018, In : BMC Complementary and Alternative Medicine. 18, 1, 132.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Resveratrol induces sumoylated COX-2-dependent anti-proliferation in human prostate cancer LNCaP cells

Cheng, T. M., Chin, Y. T., Ho, Y., Chen, Y. R., Yang, Y. N., Yang, Y. C., Shih, Y. J., Lin, T. I., Lin, H. Y. & Davis, P. J., Feb 1 2018, In : Food and Chemical Toxicology. 112, p. 67-75 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Resveratrol inhibits human leiomyoma cell proliferation via crosstalk between integrin αvβ3 and IGF-1R

Ho, Y., SH Yang, Y. C., Chin, Y. T., Chou, S. Y., Chen, Y. R., Shih, Y. J., Whang-Peng, J., Changou, C. A., Liu, H. L., Lin, S. J., Tang, H. Y., Lin, H. Y. & Davis, P. J., Oct 1 2018, In : Food and Chemical Toxicology. 120, p. 346-355 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Ribonucleotide reductase subunit M2B deficiency leads to mitochondrial permeability transition pore opening and is associated with aggressive clinicopathologic manifestations of breast cancer

Xue, L., Liu, X., Wang, Q., Liu, C. Q., Chen, Y., Jia, W., Hsie, R., Chen, Y., Luh, F., Zheng, S. & Yen, Y., Jan 1 2018, In : American Journal of Translational Research. 10, 11, p. 3635-3649 15 p., AJTR0084684.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Risk analysis of malignant potential of oral verrucous hyperplasia: A follow-up study of 269 patients and copy number variation analysis

Wu, M. H., Luo, J. D., Wang, W. C., Chang, T. H., Hwang, W. L., Lee, K. H., Liu, S. Y., Yang, J. W., Chiou, C. T., Chang, C. H. & Chiang, W. F., Jan 1 2018, (Accepted/In press) In : Head and Neck.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Risk of fracture in transfusion-naïve thalassemia population: A nationwide population-based retrospective cohort study

Chen, Y. G., Lu, C. S., Lin, T. Y., Lin, C. L., Tzeng, H. E. & Tsai, C. H., Jan 1 2018, In : Bone. 106, p. 121-125 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Significance of cyclin D1 overexpression in progression and radio-resistance of pediatric ependymomas

Liang, M. L., Hsieh, T. H., Liu, Y. R., Chen, Y. W., Lee, Y. Y., Chang, F. C., Lin, S. C., Huang, M. C., Ho, D. M. T., Wong, T-T., Yen, Y. & Yang, M. H., Jan 1 2018, In : Oncotarget. 9, 2, p. 2527-2542 16 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Sphere-Formation Assay: Three-dimensional in vitro culturing of prostate cancer stem/Progenitor sphere-forming cells

Bahmad, H. F., Cheaito, K., Chalhoub, R. M., Hadadeh, O., Monzer, A., Ballout, F., El-Hajj, A., Mukherji, D., Liu, Y. N., Daoud, G. & Abou-Kheir, W., Aug 28 2018, In : Frontiers in Oncology. 8, AUG, 347.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Systematic polypharmacology and drug repurposing via an integrated L1000-based Connectivity Map database mining

Liu, T. P., Hsieh, Y. Y., Chou, C. J. & Yang, P. M., Nov 1 2018, In : Royal Society Open Science. 5, 11, 181321.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Targeting galectin-1 impairs castration-resistant prostate cancer progression and invasion

Shih, T-C., Liu, R., Wu, C-T., Li, X., Xiao, W., Deng, X., Kiss, S., Wang, T., Chen, X-J., Carney, R., Kung, H-J., Duan, Y., Ghosh, P. M. & Lam, K. S., 2018, In : Clinical Cancer Research. 24, 17, p. 4319-4331 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Ten-eleven translocation 1 (TET1) gene is a potential target of miR-21-5p in human colorectal cancer

Cheng, Y. W., Chou, C. J. & Yang, P. M., Mar 1 2018, In : Surgical Oncology. 27, 1, p. 76-81 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Tetrac downregulates β-catenin and HMGA2 to promote the effect of resveratrol in colon cancer

Nana, A. W., Chin, Y. T., Lin, C. Y., Ho, Y., Bennett, J. A., Shih, Y. J., Chen, Y. R., Changou, C. A., Pedersen, J. Z., Incerpi, S., Liu, L. F., Whang-Peng, J., Fu, E., Li, W. S., Mousa, S. A., Lin, H. Y. & Davis, P. J., Mar 1 2018, In : Endocrine-Related Cancer. 25, 3, p. 279-293 15 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells

Tu, H. J., Lin, Y. J., Chao, M. W., Sung, T. Y., Wu, Y. W., Chen, Y. Y., Lin, M. H., Liou, J. P., Pan, S. L. & Yang, C. R., Dec 29 2018, In : Clinical Epigenetics. 10, 1, 162.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes

Wang, Y. C., Chang, K. C., Lin, B. W., Lee, J. C., Lai, C. H., Lin, L. J., Yen, Y., Lin, C. S., Yang, S. J., Lin, P. C., Lee, C. T. & Hung, L. Y., Jun 1 2018, In : Experimental and Molecular Medicine. 50, 6, p. 70 70.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Thyroid Hormone in the Clinic and Breast Cancer

Hercbergs, A., Mousa, S. A., Leinung, M., Lin, H. Y. & Davis, P. J., Feb 13 2018, (Accepted/In press) In : Hormones and Cancer. p. 1-5 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Thyroid Hormone Promotes β-Catenin Activation and Cell Proliferation in Colorectal Cancer

Lee, Y. S., Chin, Y. T., Shih, Y. J., Nana, A. W., Chen, Y. R., Wu, H. C., Yang, Y. C. S. H., Lin, H. Y. & Davis, P. J., Jan 29 2018, (Accepted/In press) In : Hormones and Cancer. p. 1-10 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Thyroxine inhibits resveratrol-caused apoptosis by PD-L1 in ovarian cancer cells

Chin, Y. T., Wei, P. L., Ho, Y., Nana, A. W., Changou, C. A., Chen, Y. R., Yang, Y. C. SH., Hsieh, M. T., Hercbergs, A., Davis, P. J., Shih, Y. J. & Lin, H. Y., May 1 2018, In : Endocrine-Related Cancer. 25, 5, p. 533-545 13 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
6 Citations (Scopus)

Tyrosine kinase inhibitors for advanced or metastatic thyroid cancer: a meta-analysis of randomized controlled trials

Liu, J. W., Chen, C., Loh, E. W., Chu, C. C., Wang, M. Y., Ouyang, H. J., Chang, Y. T., Zhuang, W. Z., Chou, C. W., Huang, D. J., Lee, C. H., Yen, Y. & Tam, K. W., 2018, In : Current Medical Research and Opinion. p. 1-9 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Validation of Assaying Carcinoembryonic Antigen in Human Serum by Using Immunomagnetic Reduction

Wei, P. L., Lee, L. T., Tseng, L. M. & Huang, K. W., Dec 1 2018, In : Scientific Reports. 8, 1, 10002.

Research output: Contribution to journalArticle

1 Citation (Scopus)
7 Citations (Scopus)
2019

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Action of Reverse T3 on Cancer Cells

Lin, H. Y., Tang, H. Y., Leinung, M., Mousa, S. A., Hercbergs, A. & Davis, P. J., Jan 1 2019, In : Endocrine Research.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Alternative splicing in human cancer cells is modulated by the amiloride derivative 3,5-diamino-6-chloro-N-(N-(2,6-dichlorobenzoyl)carbamimidoyl)pyrazine-2-carboxide

Lee, C. C., Chang, W. H., Chang, Y. S., Yang, J. M., Chang, C. S., Hsu, K. C., Chen, Y. T., Liu, T. Y., Chen, Y. C., Lin, S. Y., Wu, Y. C. & Chang, J. G., Jan 1 2019, In : Molecular Oncology. 13, 8, p. 1744-1762 19 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Androgen deprivation-induced ZBTB46-PTGS1 signaling promotes neuroendocrine differentiation of prostate cancer

Chen, W. Y., Zeng, T., Wen, Y. C., Yeh, H. L., Jiang, K. C., Chen, W. H., Zhang, Q., Huang, J. & Liu, Y. N., Jan 1 2019, In : Cancer Letters. 440-441, p. 35-46 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
Open Access
3 Citations (Scopus)
Open Access
2 Citations (Scopus)

Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivo

Hsieh, Y. L., Tu, H. J., Pan, S. L., Liou, J. P. & Yang, C. R., Jun 1 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 6, p. 992-1003 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Association of matrix Metalloproteinase-9 rs3918242 promoter genotypes with colorectal cancer risk

Wu, M. H., Tzeng, H. E., Wu, C. N., Yueh, T. C., Peng, Y. C., Tsai, C. H., Wang, Y. C., Ke, T. W., Pei, J. S., Chang, W. S., Tsai, C. W. & Bau, D. T., Jan 1 2019, In : Anticancer Research. 39, 12, p. 6523-6529 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Chicken-Derived Humanized Antibody Targeting a Novel Epitope F2pep of Fibroblast Growth Factor Receptor 2: Potential Cancer Therapeutic Agent

Tsai, K. C., Chang, C. D., Cheng, M. H., Lin, T. Y., Lo, Y. N., Yang, T. W., Chang, F. L., Chiang, C. W., Lee, Y. C. & Yen, Y., Jan 31 2019, In : ACS Omega. 4, 1, p. 2387-2397 11 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Comparison of the biological impact of UVA and UVB upon the skin with functional proteomics and immunohistochemistry

Wang, P. W., Hung, Y. C., Lin, T. Y., Fang, J. Y., Yang, P. M., Chen, M. H. & Pan, T. L., Dec 2019, In : Antioxidants. 8, 12, 569.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Dental Pulp Stem Cell Transplantation with 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside Accelerates Alveolar Bone Regeneration in Rats

Lin, C. Y., Kuo, P. J., Chin, Y. T., Weng, I. T., Lee, H. W., Huang, H. M., Lin, H. Y., Hsiung, C. N., Chan, Y. H. & Lee, S. Y., Apr 1 2019, In : Journal of Endodontics. 45, 4, p. 435-441 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Dietary flavonoids luteolin and quercetin inhibit migration and invasion of squamous carcinoma through reduction of src/stat3/s100a7 signaling

Fan, J. J., Hsu, W. H., Lee, K. H., Chen, K. C., Lin, C. W., Lee, Y. L. A., Ko, T. P., Lee, L. T., Lee, M. T., Chang, M. S. & Cheng, C. H., Nov 2019, In : Antioxidants. 8, 11, 557.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Differential effect of herbal tea extracts on free fatty acids-, ethanol- and acetaminophen-induced hepatotoxicity in FL83B hepatocytes

Chen, G. W., Chen, T. Y. & Yang, P. M., Jan 1 2019, (Accepted/In press) In : Drug and Chemical Toxicology.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Does long-term use of antidiabetic drugs changes cancer risk?

Liu, Y. C., Nguyen, P. A., Humayun, A., Chien, S. C., Yang, H. C., Asdary, R. N., Syed-Abdul, S., Hsu, M. H., Moldovan, M., Yen, Y., Li, Y. C., Jian, W. S. & Iqbal, U., Oct 1 2019, In : Medicine (United States). 98, 40, p. e17461 e17461.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Dysregulation of cystathionine γ-lyase promotes prostate cancer progression and metastasis

Wang, Y. H., Huang, J. T., Chen, W. L., Wang, R. H., Kao, M. C., Pan, Y. R., Chan, S. H., Tsai, K. W., Kung, H. J., Lin, K. T. & Wang, L. H., Oct 4 2019, In : EMBO Reports. 20, 10, e45986.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
Open Access
3 Citations (Scopus)
Open Access

Histone demethylase KDM4C stimulates the proliferation of prostate cancer cells via activation of AKT and c-Myc

Lin, C. Y., Wang, B. J., Chen, B. C., Tseng, J. C., Jiang, S. S., Tsai, K. K., Shen, Y. Y., Yuh, C. H., Sie, Z. L., Wang, W. C., Kung, H. J. & Chuu, C. P., Nov 13 2019, In : Cancers. 11, 11, 1785.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Identification of two independent SUMO-interacting motifs in Fas-associated factor 1 (FAF1): Implications for mineralocorticoid receptor (MR)-mediated transcriptional regulation

Wang, C. H., Hung, P. W., Chiang, C. W., Lombès, M., Chen, C. H., Lee, K. H., Lo, Y. C., Wu, M. H., Chang, W. C. & Lin, D. Y., Aug 1 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 8, p. 1282-1297 16 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Immune effector monocyte–neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer

Hagerling, C., Gonzalez, H., Salari, K., Wang, C. Y., Lin, C., Robles, I., van Gogh, M., Dejmek, A., Jirström, K. & Werb, Z., Oct 22 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 43, p. 21704-21714 11 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
Open Access
2 Citations (Scopus)

In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer Cells

Chen, J. C., Hsieh, Y. Y., Lo, H. L., Li, A., Chou, C. J. & Yang, P. M., Sep 9 2019, In : Biomolecules. 9, 9

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC

Wang, H. J., Pochampalli, M., Wang, L. Y., Zou, J. X., Li, P. S., Hsu, S. C., Wang, B. J., Huang, S. H., Yang, P., Yang, J. C., Chu, C. Y., Hsieh, C. L., Sung, S. Y., Li, C. F., Tepper, C. G., Ann, D. K., Gao, A. C., Evans, C. P., Izumiya, Y., Chuu, C. P. & 3 others, Wang, W. C., Chen, H. W. & Kung, H. J., Jan 3 2019, In : Oncogene. 38, 1, p. 17-32

Research output: Contribution to journalArticle

14 Citations (Scopus)

Leptin-derived peptides block leptin-induced proliferation by reducing expression of pro-inflammatory genes in hepatocellular carcinoma cells

Ho, Y., Wang, S. H., Chen, Y. R., Li, Z. L., Chin, Y. T., Yang, Y. C. S. H., Wu, Y. H., Su, K. W., Chu, H. R., Chiu, H. C., Crawford, D. R., Shih, Y. J., Grasso, P., Tang, H. Y., Lin, H. Y., Davis, P. J., Whang-Peng, J. & Wang, K., Nov 1 2019, In : Food and Chemical Toxicology. 133, p. 110808 110808.

Research output: Contribution to journalArticle

Leukemia Inhibitory Factor Promotes Castration-resistant Prostate Cancer and Neuroendocrine Differentiation by Activated ZBTB46

Liu, Y-N., Niu, S., Chen, W-Y., Zhang, Q., Tao, Y., Chen, W-H., Jiang, K-C., Chen, X., Shi, H., Liu, A., Li, J., Li, Y., Lee, Y-C., Zhang, X. & Huang, J., Apr 8 2019, In : Clinical cancer research : an official journal of the American Association for Cancer Research.

Research output: Contribution to journalArticle

5 Citations (Scopus)