Ph.D. Program for Cancer Molecular Biology and Drug Discovery

  • No. 250 Wu-Xing Street

    11031 Taipei

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2014

MiR326 maturation is crucial for VEGF-C-driven cortactin expression and esophageal cancer progression

Hong, C. C., Chen, P. S., Chiou, J., Chiu, C. F., Yang, C. Y., Hsiao, M., Chang, Y. W., Yu, Y. H., Hung, M. C., Hsu, N. W., Shiah, S. G., Hsu, N. Y. & Su, J. L., Nov 1 2014, In : Cancer Research. 74, 21, p. 6280-6290 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

MiRNA-221 negatively regulated downstream p27Kip1 gene expression involvement in pterygium pathogenesis

Wu, C. W., Cheng, Y. W., Hsu, N. Y., Yeh, K. T., Tsai, Y. Y., Chiang, C. C., Wang, W. R. & Tung, J. N., Jul 18 2014, In : Molecular Vision. 20, p. 1048-1056 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Modified salicylanilide and 3-phenyl-2 H -benzo[ e ][1,3]oxazine-2,4(3 H)-dione derivatives as novel inhibitors of osteoclast differentiation and bone resorption

Chen, C. L., Liu, F. L., Lee, C. C., Chen, T. C., Ahmed Ali, A. A., Sytwu, H. K., Chang, D. M. & Huang, H. S., Oct 9 2014, In : Journal of Medicinal Chemistry. 57, 19, p. 8072-8085 14 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Modulation of angiogenesis by thyroid hormone and hormone analogues: Implications for cancer management

Mousa, S. A., Lin, H. Y., Tang, H. Y., Hercbergs, A., Luidens, M. K. & Davis, P. J., 2014, In : Angiogenesis. 17, 3, p. 463-469 7 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Moniliformediquinone induces in vitro and in vivo antitumor activity through glutathione involved DNA damage response and mitochondrial stress in human hormone refractory prostate cancer

Hsu, J. L., Lee, Y. J., Leu, W. J., Dong, Y. S., Pan, S. L., Uang, B. J. & Guh, J. H., 2014, In : Journal of Urology. 191, 5, p. 1429-1438 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Mutants TP53 p.R273H and p.R273C but not p.R273G Enhance Cancer Cell Malignancy

Li, J., Yang, L., Gaur, S., Zhang, K., Wu, X., Yuan, Y. C., Li, H., Hu, S., Weng, Y. & Yen, Y., Jan 1 2014, In : Human Mutation. 35, 5, p. 575-584 10 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Nickel accumulation in lung tissues is associated with increased risk of p53 mutation in lung cancer patients

Chiou, Y. H., Wong, R. H., Chao, M. R., Chen, C. Y., Liou, S. H. & Lee, H., Oct 1 2014, In : Environmental and Molecular Mutagenesis. 55, 8, p. 624-632 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

NPRL-Z-1, as a new topoisomerase II poison, induces cell apoptosis and ROS generation in human renal carcinoma cells

Wu, S. Y., Pan, S. L., Xiao, Z. Y., Hsu, J. L., Chen, M. C., Lee, K. H. & Teng, C. M., Nov 5 2014, In : PLoS One. 9, 11, e112220.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Orally active microtubule-targeting agent, MPT0B271, for the treatment of human non-small cell lung cancer, alone and in combination with erlotinib

Tsai, A. C., Wang, C. Y., Liou, J. P., Pai, H. C., Hsiao, C. J., Chang, J. Y., Wang, J. C., Teng, C. M. & Pan, S. L., 2014, In : Cell Death and Disease. 5, 4, e1162.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Paxillin promotes tumor progression and predicts survival and relapse in oral cavity squamous cell carcinoma by microRNA-218 targeting

Wu, D. W., Chuang, C. Y., Lin, W. L., Sung, W. W., Cheng, Y. W. & Lee, H., 2014, In : Carcinogenesis. 35, 8

Research output: Contribution to journalArticle

39 Citations (Scopus)

Pharmacologic down-regulation of EZH2 suppresses bladder cancer in vitro and in vivo

Tang, S. H., Huang, H. S., Wu, H. U., Tsai, Y. T., Chuang, M. J., Yu, C. P., Huang, S. M., Sun, G. H., Chang, S. Y., Hsiao, P. W., Yu, D. S. & Cha, T. L., 2014, In : Oncotarget. 5, 21, p. 10342-10355 14 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Phosphorylation of paxillin confers cisplatin resistance in non-small cell lung cancer via activating ERK-mediated Bcl-2 expression

Wu, D. W., Wu, T. C., Wu, J. Y., Cheng, Y. W., Chen, Y. C., Lee, M. C., Chen, C. Y. & Lee, H., Aug 28 2014, In : Oncogene. 33, 35, p. 4385-4395 11 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Radiation induces senescence and a bystander effect through metabolic alterations.

Liao, E. C., Hsu, Y. T., Chuah, Q. Y., Lee, Y. J., Hu, J. Y., Huang, T. C., Yang, P. M. & Chiu, S. J., 2014, In : Cell Death and Disease. 5

Research output: Contribution to journalArticle

42 Citations (Scopus)

Reciprocal regulation of autophagy and dNTP pools in human cancer cells

Chen, W., Zhang, L., Zhang, K., Zhou, B., Kuo, M. L., Hu, S., Chen, L., Tang, M., Chen, Y. R., Yang, L., Ann, D. K. & Yen, Y., Jan 1 2014, In : Autophagy. 10, 7, p. 1272-1284 13 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Ring fusion strategy for the synthesis of anthra[2,3-d ]oxazole-2-thione-5,10-dione homologues as DNA topoisomerase inhibitors and as antitumor agents

Chen, C. L., Liu, F. L., Lee, C. C., Chen, T. C., Chang, W. W., Guh, J. H., Ahmed Ali, A. A., Chang, D. M. & Huang, H. S., Nov 24 2014, In : European Journal of Medicinal Chemistry. 87, p. 30-38 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

SCP phosphatases suppress renal cell carcinoma by stabilizing PML and inhibiting mTOR/HIF signaling

Lin, Y. C., Lu, L. T., Chen, H. Y., Duan, X., Lin, X., Feng, X. H., Tang, M. J. & Chen, R. H., Dec 1 2014, In : Cancer Research. 74, 23, p. 6935-6946 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Sirtuin 7 plays a role in ribosome biogenesis and protein synthesis

Tsai, Y. C., Greco, T. M. & Cristea, I. M., 2014, In : Molecular and Cellular Proteomics. 13, 1, p. 73-83 11 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Suppression of pancreatic cancer by sulfated non-anticoagulant low molecular weight heparin

Sudha, T., Yalcin, M., Lin, H. Y., Elmetwally, A. M., Nazeer, T., Arumugam, T., Phillips, P. & Mousa, S. A., Aug 1 2014, In : Cancer Letters. 350, 1-2, p. 25-33 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Synergistic interaction between the HDAC inhibitor, MPT0E028, and sorafenib in liver cancer cells in vitro and in vivo

Chen, C. H., Chen, M. C., Wang, J. C., Tsai, A. C., Chen, C. S., Liou, J. P., Pan, S. L. & Teng, C. M., 2014, In : Clinical Cancer Research. 20, 5, p. 1274-1287 14 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

The mechanisms by which pardaxin, a natural cationic antimicrobial peptide, targets the endoplasmic reticulum and induces c-FOS

Ting, C. H., Huang, H. N., Huang, T. C., Wu, C. J. & Chen, J. Y., Apr 2014, In : Biomaterials. 35, 11, p. 3627-3640 14 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

The prognostic value of ribonucleotide reductase small subunit M2 in predicting recurrence for prostate cancers

Huang, Y., Liu, X., Wang, Y. H., Yeh, S. D., Chen, C. L., Nelson, R. A., Chu, P., Wilson, T. & Yen, Y., Jan 2014, In : Urologic Oncology: Seminars and Original Investigations. 32, 1

Research output: Contribution to journalArticle

12 Citations (Scopus)

Thyroid hormone inhibition in L6 myoblasts of IGF-I-mediated glucose uptake and proliferation: New roles for integrin αvβ3

Incerpi, S., Hsieh, M. T., Lin, H. Y., Cheng, G. Y., De Vito, P., Fiore, A. M., Ahmed, R. G., Salvia, R., Candelotti, E., Leone, S., Luly, P., Pedersen, J. Z., Davis, F. B. & Davis, P. J., Jul 15 2014, In : American Journal of Physiology - Cell Physiology. 307, 2

Research output: Contribution to journalArticle

18 Citations (Scopus)

Tumor suppressor FOXO3 regulates ribonucleotide reductase subunit RRM2B and impacts on survival of cancer patients

Cho, E. C., Kuo, M. L., Liu, X., Yang, L., Hsieh, Y. C., Wang, J., Cheng, Y. & Yen, Y., 2014, In : Oncotarget. 5, 13, p. 4834-4844 11 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Up-Regulation of FOXM1 by E6 Oncoprotein through the MZF1/NKX2-1 Axis Is Required for Human Papillomavirus-Associated Tumorigenesis

Chen, P. M., Cheng, Y. W., Wang, Y. C., Wu, T. C., Chen, C. Y. & Lee, H., 2014, In : Neoplasia. 16, 11, p. 961-971 11 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Vascular endothelial growth factor gene polymorphism and protein expression in the pathogenesis of pterygium

Peng, M. L., Tsai, Y. Y., Tung, J. N., Chiang, C. C., Huang, Y. C., Lee, H. & Cheng, Y. W., 2014, In : British Journal of Ophthalmology. 98, 4, p. 556-561 6 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2013

Activated PAR-2 regulates pancreatic cancer progression through ILK/HIF-α-induced TGF-α expression and MEK/VEGF-a-mediated angiogenesis

Chang, L. H., Pan, S. L., Lai, C. Y., Tsai, A. C. & Teng, C. M., Aug 2013, In : American Journal of Pathology. 183, 2, p. 566-575 10 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Activation of a novel ubiquitin-independent proteasome pathway when RNA polymerase II encounters a protein roadblock

Ban, Y., Ho, C. W., Lin, R. K., Lyu, Y. L. & Liu, L-F., 2013, In : Molecular and Cellular Biology. 33, 20, p. 4008-4016 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Activation of NF-κB by SOD2 promotes the aggressiveness of lung adenocarcinoma by modulating NKX2-1-mediated IKKβ expression

Chen, P. M., Wu, T. C., Wang, Y. C., Cheng, Y. W., Sheu, G. T., Chen, C. Y. & Lee, H., Nov 2013, In : Carcinogenesis. 34, 11, p. 2655-2663 9 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway in high-grade liposarcoma

Zhang, K., Chu, K., Wu, X., Gao, H., Wang, J., Yuan, Y. C., Loera, S., Ho, K., Wang, Y., Chow, W., Un, F., Chu, P. & Yen, Y., Jan 15 2013, In : Cancer Research. 73, 4, p. 1298-1307 10 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Association of epidermal growth factor receptor mutations with human papillomavirus 16/18 E6 oncoprotein expression in non-small cell lung cancer

Tung, M. C., Wu, H. H., Cheng, Y. W., Wang, L., Chen, C. Y., Yeh, S. D., Wu, T. C. & Lee, H., Sep 15 2013, In : Cancer. 119, 18, p. 3367-3376 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Berbamine inhibits the growth of liver cancer cells and cancer-initiating cells by targeting Ca2+/calmodulin- dependent protein kinase II

Meng, Z., Li, T., Ma, X., Wang, X., Ness, C. V., Gan, Y., Zhou, H., Tang, J., Lou, G., Wang, Y., Wu, J., Yen, Y., Xu, R. & Huang, W., Oct 2013, In : Molecular Cancer Therapeutics. 12, 10, p. 2067-2077 11 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

BPDE-like DNA adduct level in oral tissue may act as a risk biomarker of oral cancer

Chuang, C. Y., Tung, J. N., Su, M. C., Wu, B. C., Hsin, C. H., Chen, Y. J., Yeh, K. T., Lee, H. & Cheng, Y. W., Jan 2013, In : Archives of Oral Biology. 58, 1, p. 102-109 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Carboxyl-terminal modulator protein positively regulates Akt phosphorylation and acts as an oncogenic driver in breast cancer

Liu, Y. P., Liao, W. C., Ger, L. P., Chen, J. C., Hsu, T. I., Lee, Y. C., Chang, H. T., Chen, Y. C., Jan, Y. H., Lee, K. H., Zeng, Y. H., Hsiao, M. & Lu, P. J., Oct 15 2013, In : Cancer Research. 73, 20, p. 6194-6205 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Chromosomal Instability Triggered by Rrm2b Loss Leads to IL-6 Secretion and Plasmacytic Neoplasms

Chang, L., Guo, R., Huang, Q. & Yen, Y., May 30 2013, In : Cell Reports. 3, 5, p. 1389-1397 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Depletion of 4E-BP1 and regulation of autophagy lead to YXM110-induced anticancer effects

Lai, C. Y., Pan, S. L., Yang, X. M., Chang, L. H., Chang, Y. L., Yang, P. C., Lee, K. H. & Teng, C. M., Sep 2013, In : Carcinogenesis. 34, 9, p. 2050-2060 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Different impact of IL10 haplotype on prognosis in lung squamous cell carcinoma and adenocarcinoma

Wang, Y. C., Sung, W. W., Wang, L., Cheng, Y. W., Chen, C. Y., Wu, T. C., Shieh, S. H. & Lee, H., Jun 2013, In : Anticancer Research. 33, 6, p. 2729-2736 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Human Papillomavirus Up-Regulates MMP-2 and MMP-9 Expression and Activity by Inducing Interleukin-8 in Lung Adenocarcinomas

Shiau, M. Y., Fan, L. C., Yang, S. C., Tsao, C. H., Lee, H., Cheng, Y. W., Lai, L. C. & Chang, Y. H., Jan 21 2013, In : PLoS ONE. 8, 1, e54423.

Research output: Contribution to journalArticle

20 Citations (Scopus)

IL-10 promotes tumor aggressiveness via upregulation of CIP2A transcription in lung adenocarcinoma

Sung, W. W., Wang, Y. C., Lin, P. L., Cheng, Y. W., Chen, C. Y., Wu, T. C. & Lee, H., Aug 1 2013, In : Clinical Cancer Research. 19, 15, p. 4092-4103 12 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Incomplete success of angioinhibitor therapy in cancer: Estimation of contribution of pro-angiogenic activity of patient thyroid hormone

Davis, P. J., Yalcin, M., Lin, H. Y., Tang, H. Y., Hercbergs, A., Leith, J. T., Davis, F. B., Luidens, M. K. & Mousa, S. A., 2013, In : Journal of Cancer Science and Therapy. 5, 12, p. 441-445 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Mechanisms of ceramide-induced COX-2-dependent apoptosis in human ovarian cancer OVCAR-3 cells partially overlapped with resveratrol

Lin, H. Y., Delmas, D., Vang, O., Hsieh, T. C., Lin, S., Cheng, G. Y., Chiang, H. L., Chen, C. E., Tang, H. Y., Crawford, D. R., Whang-Peng, J., Hwang, J., Liu, L. F. & Wu, J. M., Aug 2013, In : Journal of Cellular Biochemistry. 114, 8, p. 1940-1954 15 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

MicroRNA-320 suppresses the stem cell-like characteristics of prostate cancer cells by downregulating the Wnt/beta-catenin signaling pathway

Hsieh, I. S., Chang, K. C., Tsai, Y. T., Ke, J. Y., Lu, P. J., Lee, K. H., Yeh, S. D., Hong, T. M. & Chen, Y. L., Mar 2013, In : Carcinogenesis. 34, 3, p. 530-538 9 p.

Research output: Contribution to journalArticle

159 Citations (Scopus)

MicroRNA-657 promotes tumorigenesis in hepatocellular carcinoma by targeting transducin-like enhancer protein 1 through nuclear factor kappa B pathways

Zhang, L., Yang, L., Liu, X., Chen, W., Chang, L., Chen, L., Loera, S., Chu, P., Huang, W. C., Liu, Y. R. & Yen, Y., May 1 2013, In : Hepatology. 57, 5, p. 1919-1930 12 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

MnSOD promotes tumor invasion via upregulation of FoxM1-MMP2 axis and related with poor survival and relapse in lung adenocarcinomas

Chen, P. M., Wu, T. C., Shieh, S. H., Wu, Y. H., Li, M. C., Sheu, G. T., Cheng, Y. W., Chen, C. Y. & Lee, H., Mar 2013, In : Molecular Cancer Research. 11, 3, p. 261-271 11 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Molecular mechanisms of actions of formulations of the thyroid hormone analogue, tetrac, on the inflammatory response

Davis, P. J., Glinsky, G. V., Lin, H. Y., Incerpi, S., Davis, F. B., Mousa, S. A., Tang, H. Y., Hercbergs, A. & Luidens, M. K., 2013, In : Endocrine Research. 38, 2, p. 112-118 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Moscatilin inhibits migration and metastasis of human breast cancer MDA-MB-231 cells through inhibition of Akt and Twist signaling pathway

Pai, H. C., Chang, L. H., Peng, C. Y., Chang, Y. L., Chen, C. C., Shen, C. C., Teng, C. M. & Pan, S. L., Mar 2013, In : Journal of Molecular Medicine. 91, 3, p. 347-356 10 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Nuclear monomeric integrin αv in cancer cells is a coactivator regulated by thyroid hormone

Lin, H. Y., Su, Y. F., Hsieh, M. T., Lin, S., Meng, R., London, D., Lin, C., Tang, H. Y., Hwang, J., Davis, F. B., Mousa, S. A. & Davis, P. J., Aug 2013, In : FASEB Journal. 27, 8, p. 3209-3216 8 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Optimization of global DNA methylation measurement by LC-MS/MS and its application in lung cancer patients

Hu, C. W., Lee, H., Chen, J. L., Li, Y. J. & Chao, M. R., 2013, In : Analytical and Bioanalytical Chemistry. 405, 27, p. 8859-8869 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Pin1 acts as a negative regulator of the G2/M transition by interacting with the Aurora-A-Bora complex

Lee, Y. C., Que, J., Chen, Y. C., Lin, J. T., Liou, Y. C., Liao, P. C., Liu, Y. P., Lee, K. H., Lin, L. C., Hsiao, M., Hung, L. Y., Huang, C. Y. & Lu, P. J., Nov 1 2013, In : Journal of Cell Science. 126, 21, p. 4862-4872 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
20 Citations (Scopus)

Proteomic and functional analysis of zebrafish after administration of antimicrobial peptide epinecidin-1

Huang, T. C. & Chen, J. Y., Feb 2013, In : Fish and Shellfish Immunology. 34, 2, p. 593-598 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)