Ph.D. Program for Cancer Molecular Biology and Drug Discovery

  • No. 250 Wu-Xing Street

    11031 Taipei

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2014

A vaccine targeted at CETP alleviates high fat and high cholesterol diet-induced atherosclerosis and non-alcoholic steatohepatitis in rabbit

Liaw, Y. W., Lin, C. Y., Lai, Y. S., Yang, T. C., Wang, C. J., Whang-Peng, J., Liu, L. F., Lin, C. P., Nieh, S., Lu, S. C. & Hwang, J., Dec 8 2014, In : PLoS One. 9, 12, e111529.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells

Lee, H. Y., Tsai, A. C., Chen, M. C., Shen, P. J., Cheng, Y. C., Kuo, C. C., Pan, S. L., Liu, Y. M., Liu, J. F., Yeh, T. K., Wang, J. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., May 22 2014, In : Journal of Medicinal Chemistry. 57, 10, p. 4009-4022 14 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Berberis libanotica ehrenb extract shows anti-neoplastic effects on prostate cancer stem/progenitor cells

El-Merahbi, R., Liu, Y. N., Eid, A., Daoud, G., Hosry, L., Monzer, A., Mouhieddine, T. H., Hamade, A., Najjar, F. & Abou-Kheir, W., Nov 7 2014, In : PLoS One. 9, 11, e112453.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Biologically active leptin-related synthetic peptides activate STAT3 via phosphorylation of ERK1/2 and PI-3K

Lin, H. Y., Yang, S. H., Tang, H. Y., Cheng, G. Y., Davis, P. J. & Grasso, P., 2014, In : Peptides. 57, p. 95-100 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Cancer: Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells

Qiu, F., Chen, Y. R., Liu, X., Chu, C. Y., Shen, L. J., Xu, J., Gaur, S., Forman, H. J., Zhang, H., Zheng, S., Yen, Y., Huang, J., Kung, H. J. & Ann, D. K., Apr 1 2014, In : Science Signaling. 7, 319

Research output: Contribution to journalArticle

64 Citations (Scopus)

Cell-autonomous heparanase modulates self-renewal and migration in bone marrow-derived mesenchymal stem cells

Cheng, C. C., Lee, Y. H., Lin, S. P., Huangfu, W. C. & Liu, I. H., Mar 13 2014, In : Journal of Biomedical Science. 21, 1, 21.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Circulating anti-cyclic citrullinated peptide antibody in patients with rheumatoid arthritis and chronic obstructive pulmonary disease

Yang, D. H., Tu, C. C., Wang, S. C., Wei, C. C. & Cheng, Y. W., 2014, In : Rheumatology International. 34, 7, p. 971-977 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Clinical research of mortality in emergency air medical transport

Chen, W. L., Ma, H. P., Wu, C. H., Chiou, H. Y., Yen, Y., Chiu, W. T. & Tsai, S. H., 2014, In : BioMed Research International. 2014, 767402.

Research output: Contribution to journalArticle

3 Citations (Scopus)

C-Myc suppresses microRNA-29b to promote tumor aggressiveness and poor outcomes in non-small cell lung cancer by targeting FHIT

Wu, D. W., Hsu, N. Y., Wang, Y. C., Lee, M. C., Cheng, Y. W., Chen, C. Y. & Lee, H., Jun 9 2014, In : Oncogene. 34, 16, p. 2072-2082 11 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Combination therapy targeting ectopic ATP synthase and 26S proteasome induces ER stress in breast cancer cells

Chang, H. Y., Huang, T. C., Chen, N. N., Huang, H. C. & Juan, H. F., Jan 1 2014, In : Cell Death and Disease. 5, 11, e1540.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA

Zuckerman, J. E., Gritli, I., Tolcher, A., Heidel, J. D., Lim, D., Morgan, R., Chmielowski, B., Ribas, A., Davis, M. E. & Yen, Y., Aug 5 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 31, p. 11449-11454 6 p.

Research output: Contribution to journalArticle

162 Citations (Scopus)

Curative use of forequarter amputation for recurrent breast cancer over an axillary area: a case report and literature review

Tsai, C. H., Tzeng, H. E., Juang, W. K., Chu, P. G., Fann, P., Fong, Y. C., Hsu, H. C. & Yen, Y., 2014, In : World Journal of Surgical Oncology. 12, p. 346 1 p.

Research output: Contribution to journalArticle

DDX3 loss by p53 inactivation promotes tumor malignancy via the MDM2/Slug/E-cadherin pathway and poor patient outcome in non-small-cell lung cancer

Wu, D. W., Lee, M. C., Wang, J., Chen, C. Y., Cheng, Y. W. & Lee, H., Mar 20 2014, In : Oncogene. 33, 12, p. 1515-1526 12 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents

Wang, M. J., Liu, Y. Q., Chang, L. C., Wang, C. Y., Zhao, Y. L., Zhao, X. B., Qian, K., Nan, X., Yang, L., Yang, X. M., Hung, H. Y., Yang, J. S., Kuo, D. H., Goto, M., Morris-Natschke, S. L., Pan, S. L., Teng, C. M., Kuo, S. C., Wu, T. S., Wu, Y. C. & 1 others, Lee, K. H., Jul 24 2014, In : Journal of Medicinal Chemistry. 57, 14, p. 6008-6018 11 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Dovitinib synergizes with oxaliplatin in suppressing cell proliferation and inducing apoptosis in colorectal cancer cells regardless of RAS-RAF mutation status

Gaur, S., Chen, L., Ann, V., Lin, W. C., Wang, Y., Chang, V. H. S., Hsu, N. Y., Shia, H. S. & Yen, Y., Feb 4 2014, In : Molecular Cancer. 13, 1, 21.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Effect of C7-substitution of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines on the selectivity towards a subclass of histone deacetylases

Lee, H. Y., Wang, L. T., Li, Y. H., Pan, S. L., Chen, Y. L., Teng, C. M. & Liou, J. P., Nov 28 2014, In : Organic and Biomolecular Chemistry. 12, 44, p. 8966-8976 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Expression of glypican 3 enriches hepatocellular carcinoma development-related genes and associates with carcinogenesis in cirrhotic livers

Liu, X., Wang, S. K., Zhang, K., Zhang, H., Pan, Q., Liu, Z., Pan, H., Xue, L., Yen, Y. & Chu, P. G., Aug 20 2014, In : Carcinogenesis. 36, 2, p. 232-242 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Frequent overexpression of HMGA2 in human atypical teratoid/rhabdoid tumor and its correlation with let-7a3/let-7b miRNA

Zhang, K., Gao, H., Wu, X., Wang, J., Zhou, W., Sun, G., Wang, J., Wang, Y., Mu, B., Kim, C., Chu, P., Ho, D. M., Ann, D. K., Wong, T. T. & Yen, Y., 2014, In : Clinical Cancer Research. 20, 5, p. 1179-1189 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Increased levels of circulating advanced glycation end-products in menopausal women with osteoporosis

Yang, D. H., Chiang, T. I., Chang, I. C., Lin, F. H., Wei, C. C. & Cheng, Y. W., 2014, In : International Journal of Medical Sciences. 11, 4, p. 453-460 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

In vitro and in vivo anti-tumour effects of MPT0B014, a novel derivative aroylquinoline, and in combination with erlotinib in human non-small-cell lung cancer cells

Tsai, A. C., Pai, H. C., Wang, C. Y., Liou, J. P., Teng, C. M., Wang, J. C. & Pan, S. L., Jan 2014, In : British Journal of Pharmacology. 171, 1, p. 122-133 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Jejunal Cancer with WRN Mutation Identified from Next-Generation Sequencing: A Case Study and Minireview

Chang, C., Shiah, H-S., Hsu, N-Y., Huang, H. Y., Chu, J-S. & Yen, Y., 2014, In : Case Reports in Surgery.

Research output: Contribution to journalArticle

LKB1 Loss at Transcriptional Level Promotes Tumor Malignancy and Poor Patient Outcomes in Colorectal Cancer

He, T. Y., Tsai, L. H., Huang, C. C., Chou, M. C. & Lee, H., 2014, In : Annals of Surgical Oncology. 21, 4, p. 703-710 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

LKB1 loss by alteration of the NKX2-1/p53 pathway promotes tumor malignancy and predicts poor survival and relapse in lung adenocarcinomas

Tsai, L. H., Chen, P. M., Cheng, Y. W., Chen, C. Y., Sheu, G. T., Wu, T. C. & Lee, H., Jul 17 2014, In : Oncogene. 33, 29, p. 3851-3860 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Loss of EGFR signaling regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance

Siu, M. K., Abou-Kheir, W., Yin, J. J., Chang, Y. S., Barrett, B., Suau, F., Casey, O., Chen, W. Y., Fang, L., Hynes, P., Hsieh, Y. Y., Liu, Y. N., Huang, J. & Kelly, K., 2014, In : Oncotarget. 5, 11, p. 3770-3784 15 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Low/negative expression of DDX3 might predict poor prognosis in non-smoker patients with oral cancer

Lee, C. H., Lin, S. H., Yang, S. F., Yang, S. M., Chen, M. K., Lee, H., Ko, J. L., Chen, C. J. & Yeh, K. T., Jan 2014, In : Oral Diseases. 20, 1, p. 76-83 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Metabolism and mis-metabolism of the neuropathological signature protein TDP-43

Huang, C. C., Bose, J. K., Majumder, P., Lee, K. H., Huang, J. T. J., Huang, J. K. & Shen, C. K. J., 2014, In : Journal of Cell Science. 127, 14, p. 3024-3038 15 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

MicroRNA-18a is elevated in prostate cancer and promotes tumorigenesis through suppressing STK4 in vitro and in vivo

Hsu, T. I., Hsu, C. H., Lee, K. H., Lin, J. T., Chen, C. S., Chang, K. C., Su, C. Y. J., Hsiao, M. & Lu, P. J., Jan 1 2014, In : Oncogenesis. 3, 4, e99.

Research output: Contribution to journalArticle

49 Citations (Scopus)

MicroRNA-21 promotes tumour malignancy via increased nuclear translocation of β-catenin and predicts poor outcome in APC-mutated but not in APC-wild-type colorectal cancer

Lin, P. L., Wu, D. W., Huang, C. C., He, T. Y., Chou, M. C., Sheu, G. T. & Lee, H., Oct 1 2014, In : Carcinogenesis. 35, 10, p. 2175-2182 8 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

MicroRNA-224 suppresses colorectal cancer cell migration by targeting Cdc42

Ke, T. W., Hsu, H. L., Wu, Y. H., Chen, W. T. L., Cheng, Y. W. & Cheng, C. W., 2014, In : Disease Markers. 2014, 617150.

Research output: Contribution to journalArticle

34 Citations (Scopus)

MicroRNA-296-5p (miR-296-5p) functions as a tumor suppressor in prostate cancer by directly targeting Pin1

Lee, K. H., Lin, F. C., Hsu, T. I., Lin, J. T., Guo, J. H., Tsai, C. H., Lee, Y. C., Lee, Y. C., Chen, C. L., Hsiao, M. & Lu, P. J., 2014, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1843, 9, p. 2055-2066 12 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

MicroRNA expression profiling in PBMCs: A potential diagnostic biomarker of chronic hepatitis C

Chang, C. C., Lin, C. C., Hsieh, W. L., Lai, H. W., Tsai, C. H. & Cheng, Y. W., 2014, In : Disease Markers. 2014, 367157.

Research output: Contribution to journalArticle

13 Citations (Scopus)

MiR-30 as a tumor suppressor connects EGF/Src signal to ERG and EMT

Kao, C. J., Martiniez, A., Shi, X. B., Yang, J., Evans, C. P., Dobi, A., Devere White, R. W. & Kung, H. J., May 8 2014, In : Oncogene. 33, 19, p. 2495-2503 9 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

MiR326 maturation is crucial for VEGF-C-driven cortactin expression and esophageal cancer progression

Hong, C. C., Chen, P. S., Chiou, J., Chiu, C. F., Yang, C. Y., Hsiao, M., Chang, Y. W., Yu, Y. H., Hung, M. C., Hsu, N. W., Shiah, S. G., Hsu, N. Y. & Su, J. L., Nov 1 2014, In : Cancer Research. 74, 21, p. 6280-6290 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

MiRNA-221 negatively regulated downstream p27Kip1 gene expression involvement in pterygium pathogenesis

Wu, C. W., Cheng, Y. W., Hsu, N. Y., Yeh, K. T., Tsai, Y. Y., Chiang, C. C., Wang, W. R. & Tung, J. N., Jul 18 2014, In : Molecular Vision. 20, p. 1048-1056 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Modified salicylanilide and 3-phenyl-2 H -benzo[ e ][1,3]oxazine-2,4(3 H)-dione derivatives as novel inhibitors of osteoclast differentiation and bone resorption

Chen, C. L., Liu, F. L., Lee, C. C., Chen, T. C., Ahmed Ali, A. A., Sytwu, H. K., Chang, D. M. & Huang, H. S., Oct 9 2014, In : Journal of Medicinal Chemistry. 57, 19, p. 8072-8085 14 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Modulation of angiogenesis by thyroid hormone and hormone analogues: Implications for cancer management

Mousa, S. A., Lin, H. Y., Tang, H. Y., Hercbergs, A., Luidens, M. K. & Davis, P. J., 2014, In : Angiogenesis. 17, 3, p. 463-469 7 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Moniliformediquinone induces in vitro and in vivo antitumor activity through glutathione involved DNA damage response and mitochondrial stress in human hormone refractory prostate cancer

Hsu, J. L., Lee, Y. J., Leu, W. J., Dong, Y. S., Pan, S. L., Uang, B. J. & Guh, J. H., 2014, In : Journal of Urology. 191, 5, p. 1429-1438 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Mutants TP53 p.R273H and p.R273C but not p.R273G Enhance Cancer Cell Malignancy

Li, J., Yang, L., Gaur, S., Zhang, K., Wu, X., Yuan, Y. C., Li, H., Hu, S., Weng, Y. & Yen, Y., Jan 1 2014, In : Human Mutation. 35, 5, p. 575-584 10 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Nickel accumulation in lung tissues is associated with increased risk of p53 mutation in lung cancer patients

Chiou, Y. H., Wong, R. H., Chao, M. R., Chen, C. Y., Liou, S. H. & Lee, H., Oct 1 2014, In : Environmental and Molecular Mutagenesis. 55, 8, p. 624-632 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

NPRL-Z-1, as a new topoisomerase II poison, induces cell apoptosis and ROS generation in human renal carcinoma cells

Wu, S. Y., Pan, S. L., Xiao, Z. Y., Hsu, J. L., Chen, M. C., Lee, K. H. & Teng, C. M., Nov 5 2014, In : PLoS One. 9, 11, e112220.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Orally active microtubule-targeting agent, MPT0B271, for the treatment of human non-small cell lung cancer, alone and in combination with erlotinib

Tsai, A. C., Wang, C. Y., Liou, J. P., Pai, H. C., Hsiao, C. J., Chang, J. Y., Wang, J. C., Teng, C. M. & Pan, S. L., 2014, In : Cell Death and Disease. 5, 4, e1162.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Paxillin promotes tumor progression and predicts survival and relapse in oral cavity squamous cell carcinoma by microRNA-218 targeting

Wu, D. W., Chuang, C. Y., Lin, W. L., Sung, W. W., Cheng, Y. W. & Lee, H., 2014, In : Carcinogenesis. 35, 8

Research output: Contribution to journalArticle

37 Citations (Scopus)

Pharmacologic down-regulation of EZH2 suppresses bladder cancer in vitro and in vivo

Tang, S. H., Huang, H. S., Wu, H. U., Tsai, Y. T., Chuang, M. J., Yu, C. P., Huang, S. M., Sun, G. H., Chang, S. Y., Hsiao, P. W., Yu, D. S. & Cha, T. L., 2014, In : Oncotarget. 5, 21, p. 10342-10355 14 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Phosphorylation of paxillin confers cisplatin resistance in non-small cell lung cancer via activating ERK-mediated Bcl-2 expression

Wu, D. W., Wu, T. C., Wu, J. Y., Cheng, Y. W., Chen, Y. C., Lee, M. C., Chen, C. Y. & Lee, H., Aug 28 2014, In : Oncogene. 33, 35, p. 4385-4395 11 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Radiation induces senescence and a bystander effect through metabolic alterations.

Liao, E. C., Hsu, Y. T., Chuah, Q. Y., Lee, Y. J., Hu, J. Y., Huang, T. C., Yang, P. M. & Chiu, S. J., 2014, In : Cell Death and Disease. 5

Research output: Contribution to journalArticle

41 Citations (Scopus)

Reciprocal regulation of autophagy and dNTP pools in human cancer cells

Chen, W., Zhang, L., Zhang, K., Zhou, B., Kuo, M. L., Hu, S., Chen, L., Tang, M., Chen, Y. R., Yang, L., Ann, D. K. & Yen, Y., Jan 1 2014, In : Autophagy. 10, 7, p. 1272-1284 13 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Ring fusion strategy for the synthesis of anthra[2,3-d ]oxazole-2-thione-5,10-dione homologues as DNA topoisomerase inhibitors and as antitumor agents

Chen, C. L., Liu, F. L., Lee, C. C., Chen, T. C., Chang, W. W., Guh, J. H., Ahmed Ali, A. A., Chang, D. M. & Huang, H. S., Nov 24 2014, In : European Journal of Medicinal Chemistry. 87, p. 30-38 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

SCP phosphatases suppress renal cell carcinoma by stabilizing PML and inhibiting mTOR/HIF signaling

Lin, Y. C., Lu, L. T., Chen, H. Y., Duan, X., Lin, X., Feng, X. H., Tang, M. J. & Chen, R. H., Dec 1 2014, In : Cancer Research. 74, 23, p. 6935-6946 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Sirtuin 7 plays a role in ribosome biogenesis and protein synthesis

Tsai, Y. C., Greco, T. M. & Cristea, I. M., 2014, In : Molecular and Cellular Proteomics. 13, 1, p. 73-83 11 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Suppression of pancreatic cancer by sulfated non-anticoagulant low molecular weight heparin

Sudha, T., Yalcin, M., Lin, H. Y., Elmetwally, A. M., Nazeer, T., Arumugam, T., Phillips, P. & Mousa, S. A., Aug 1 2014, In : Cancer Letters. 350, 1-2, p. 25-33 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)