Ph.D. Program for Cancer Molecular Biology and Drug Discovery

  • No. 250 Wu-Xing Street

    11031 Taipei

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2015

The pan-PI3K inhibitor GDC-0941 activates canonical WNT signaling to confer resistance in TNBC cells: Resistance reversal with WNT inhibitor

Tzeng, H. E., Yang, L., Chen, K., Wang, Y., Liu, Y. R., Pan, S. L., Gaur, S., Hu, S. & Yen, Y., 2015, In : Oncotarget. 6, 13, p. 11061-11073 13 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Thyroid hormones crosstalk with growth factors: Old facts and new hypotheses

Candelotti, E., Vito, P. D., Ahmed, R. G., Luly, P., Davis, P. J., Pedersen, J. Z., Lin, H. Y. & Incerpi, S., Jul 1 2015, In : Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 15, 1, p. 71-85 15 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Transforming growth factor-β promotes prostate bone metastasis through induction of microRNA-96 and activation of the mTOR pathway

Siu, M. K., Tsai, Y. C., Chang, Y. S., Yin, J. J., Suau, F., Chen, W. Y. & Liu, Y. N., Sep 3 2015, In : Oncogene. 34, 36, p. 4767-4776 10 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Underexpression of LKB1 tumor suppressor is associated with enhanced Wnt signaling and malignant characteristics of human intrahepatic cholangiocarcinoma

Wang, J., Zhang, K., Wang, J., Wu, X., Liu, X., Li, B., Zhu, Y., Yu, Y., Cheng, Q., Hu, Z., Guo, C., Hu, S., Mu, B., Tsai, C. H., Li, J., Smith, L., Yang, L., Liu, Q., Chu, P., Chang, V. & 4 others, Zhang, B., Wu, M., Jiang, X. & Yen, Y., 2015, In : Oncotarget. 6, 22, p. 18905-18920 16 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2014

A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine

Lee, K. H., Lo, H. L., Tang, W. C., Hsiao, H. H. Y. & Yang, P. M., 2014, In : Scientific Reports. 4, 6394.

Research output: Contribution to journalArticle

30 Citations (Scopus)

A germline missense mutation in COQ6 is associated with susceptibility to familial schwannomatosis

Zhang, K., Lin, J. W., Wang, J., Wu, X., Gao, H., Hsieh, Y. C., Hwu, P., Liu, Y. R., Su, L., Chiou, H. Y., Wang, D., Yuan, Y. C., Whang-Peng, J., Chiu, W. T. & Yen, Y., Oct 1 2014, In : Genetics in Medicine. 16, 10, p. 787-792 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

A lytic viral long noncoding RNA modulates the function of a latent protein

Campbell, M., Kim, K. Y., Chang, P. C., Huerta, S., Shevchenko, B., Wang, D. H., Izumiya, C., Kung, H. J. & Izumiya, Y., Feb 1 2014, In : Journal of Virology. 88, 3, p. 1843-1848 6 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis

Chou, C. C., Lee, K. H., Lai, I. L., Wang, D., Mo, X., Kulp, S. K., Shapiro, C. L. & Chen, C. S., Sep 1 2014, In : Cancer Research. 74, 17, p. 4783-4795 13 p.

Research output: Contribution to journalArticle

101 Citations (Scopus)

An improved ChIP-seq peak detection system for simultaneously identifying post-translational modified transcription factors by combinatorial fusion, using SUMOylation as an example

Cheng, C. Y., Chu, C. H., Hsu, H. W., Hsu, F. R., Tang, C. Y., Wang, W. C., Kung, H. J. & Chang, P. C., Jan 24 2014, In : BMC Genomics. 15, p. 1-14 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

A novel class I HDAC inhibitor, MPT0G030, induces cell apoptosis and differentiation in human colorectal cancer cells via HDAC1/PKCδ and E-cadherin

Wang, L. T., Liou, J. P., Li, Y. H., Liu, Y. M., Pan, S. L. & Teng, C. M., 2014, In : Oncotarget. 5, 14, p. 5651-5662 12 p.

Research output: Contribution to journalArticle

Open Access
24 Citations (Scopus)

A novel compound NSC745885 exerts an anti-tumor effect on tongue cancer SAS cells in vitro and in vivo

Chen, Y. W., Huang, H. S., Shieh, Y. S., Ma, K. H., Huang, S. H., Hueng, D. Y., Sytwu, H. K. & Lin, G. J., Aug 15 2014, In : PLoS One. 9, 8, e104703.

Research output: Contribution to journalArticle

6 Citations (Scopus)
18 Citations (Scopus)

Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro

Chin, Y. T., Hsieh, M. T., Yang, S. H., Tsai, P. W., Wang, S. H., Wang, C. C., Lee, Y. S., Cheng, G. Y., HuangFu, W. C., London, D., Tang, H. Y., Fu, E., Yen, Y., Liu, L. F., Lin, H. Y. & Davis, P. J., 2014, In : Oncotarget. 5, 24, p. 12891-12907 17 p.

Research output: Contribution to journalArticle

Open Access
46 Citations (Scopus)

Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy

Changou, C. A., Chen, Y. R., Xing, L., Yen, Y., Chuang, F. Y. S., Cheng, R. H., Bold, R. J., Ann, D. K. & Kung, H. J., Sep 30 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 39, p. 14147-14152 6 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

AR-regulated TWEAK-FN14 pathway promotes prostate cancer bone metastasis

Yin, J., Liu, Y. N., Tillman, H., Barrett, B., Hewitt, S., Ylaya, K., Fang, L., Lake, R., Corey, E., Morrissey, C., Vessella, R. & Kelly, K., Aug 15 2014, In : Cancer Research. 74, 16, p. 4306-4317 12 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
11 Citations (Scopus)

Autophagy pathway is required for IL-6 induced neuroendocrine differentiation and chemoresistance of prostate cancer LNCaP cells

Chang, P. C., Wang, T. Y., Chang, Y. T., Chu, C. Y., Lee, C. L., Hsu, H. W., Zhou, T. A., Wu, Z., Kim, R. H., Desai, S. J., Liu, S. & Kung, H. J., Feb 14 2014, In : PLoS One. 9, 2, e88556.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Autophagy promotes radiation-induced senescence but inhibits bystander effects in human breast cancer cells

Huang, Y. H., Yang, P. M., Chuah, Q. Y., Lee, Y. J., Hsieh, Y. F., Peng, C. W. & Chiu, S. J., 2014, In : Autophagy. 10, 7, p. 1212-1228 17 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

A vaccine targeted at CETP alleviates high fat and high cholesterol diet-induced atherosclerosis and non-alcoholic steatohepatitis in rabbit

Liaw, Y. W., Lin, C. Y., Lai, Y. S., Yang, T. C., Wang, C. J., Whang-Peng, J., Liu, L. F., Lin, C. P., Nieh, S., Lu, S. C. & Hwang, J., Dec 8 2014, In : PLoS ONE. 9, 12, e111529.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells

Lee, H. Y., Tsai, A. C., Chen, M. C., Shen, P. J., Cheng, Y. C., Kuo, C. C., Pan, S. L., Liu, Y. M., Liu, J. F., Yeh, T. K., Wang, J. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., May 22 2014, In : Journal of Medicinal Chemistry. 57, 10, p. 4009-4022 14 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Berberis libanotica ehrenb extract shows anti-neoplastic effects on prostate cancer stem/progenitor cells

El-Merahbi, R., Liu, Y. N., Eid, A., Daoud, G., Hosry, L., Monzer, A., Mouhieddine, T. H., Hamade, A., Najjar, F. & Abou-Kheir, W., Nov 7 2014, In : PLoS ONE. 9, 11, e112453.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Biologically active leptin-related synthetic peptides activate STAT3 via phosphorylation of ERK1/2 and PI-3K

Lin, H. Y., Yang, S. H., Tang, H. Y., Cheng, G. Y., Davis, P. J. & Grasso, P., 2014, In : Peptides. 57, p. 95-100 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Cancer: Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells

Qiu, F., Chen, Y. R., Liu, X., Chu, C. Y., Shen, L. J., Xu, J., Gaur, S., Forman, H. J., Zhang, H., Zheng, S., Yen, Y., Huang, J., Kung, H. J. & Ann, D. K., Apr 1 2014, In : Science Signaling. 7, 319

Research output: Contribution to journalArticle

72 Citations (Scopus)

Cell-autonomous heparanase modulates self-renewal and migration in bone marrow-derived mesenchymal stem cells

Cheng, C. C., Lee, Y. H., Lin, S. P., Huangfu, W. C. & Liu, I. H., Mar 13 2014, In : Journal of Biomedical Science. 21, 1, 21.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Circulating anti-cyclic citrullinated peptide antibody in patients with rheumatoid arthritis and chronic obstructive pulmonary disease

Yang, D. H., Tu, C. C., Wang, S. C., Wei, C. C. & Cheng, Y. W., 2014, In : Rheumatology International. 34, 7, p. 971-977 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Clinical research of mortality in emergency air medical transport

Chen, W. L., Ma, H. P., Wu, C. H., Chiou, H. Y., Yen, Y., Chiu, W. T. & Tsai, S. H., 2014, In : BioMed Research International. 2014, 767402.

Research output: Contribution to journalArticle

3 Citations (Scopus)

C-Myc suppresses microRNA-29b to promote tumor aggressiveness and poor outcomes in non-small cell lung cancer by targeting FHIT

Wu, D. W., Hsu, N. Y., Wang, Y. C., Lee, M. C., Cheng, Y. W., Chen, C. Y. & Lee, H., Jun 9 2014, In : Oncogene. 34, 16, p. 2072-2082 11 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Combination therapy targeting ectopic ATP synthase and 26S proteasome induces ER stress in breast cancer cells

Chang, H. Y., Huang, T. C., Chen, N. N., Huang, H. C. & Juan, H. F., Jan 1 2014, In : Cell Death and Disease. 5, 11, e1540.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA

Zuckerman, J. E., Gritli, I., Tolcher, A., Heidel, J. D., Lim, D., Morgan, R., Chmielowski, B., Ribas, A., Davis, M. E. & Yen, Y., Aug 5 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 31, p. 11449-11454 6 p.

Research output: Contribution to journalArticle

175 Citations (Scopus)

Curative use of forequarter amputation for recurrent breast cancer over an axillary area: a case report and literature review

Tsai, C. H., Tzeng, H. E., Juang, W. K., Chu, P. G., Fann, P., Fong, Y. C., Hsu, H. C. & Yen, Y., 2014, In : World Journal of Surgical Oncology. 12, p. 346 1 p.

Research output: Contribution to journalArticle

DDX3 loss by p53 inactivation promotes tumor malignancy via the MDM2/Slug/E-cadherin pathway and poor patient outcome in non-small-cell lung cancer

Wu, D. W., Lee, M. C., Wang, J., Chen, C. Y., Cheng, Y. W. & Lee, H., Mar 20 2014, In : Oncogene. 33, 12, p. 1515-1526 12 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents

Wang, M. J., Liu, Y. Q., Chang, L. C., Wang, C. Y., Zhao, Y. L., Zhao, X. B., Qian, K., Nan, X., Yang, L., Yang, X. M., Hung, H. Y., Yang, J. S., Kuo, D. H., Goto, M., Morris-Natschke, S. L., Pan, S. L., Teng, C. M., Kuo, S. C., Wu, T. S., Wu, Y. C. & 1 others, Lee, K. H., Jul 24 2014, In : Journal of Medicinal Chemistry. 57, 14, p. 6008-6018 11 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Dovitinib synergizes with oxaliplatin in suppressing cell proliferation and inducing apoptosis in colorectal cancer cells regardless of RAS-RAF mutation status

Gaur, S., Chen, L., Ann, V., Lin, W. C., Wang, Y., Chang, V. H. S., Hsu, N. Y., Shia, H. S. & Yen, Y., Feb 4 2014, In : Molecular Cancer. 13, 1, 21.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Effect of C7-substitution of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines on the selectivity towards a subclass of histone deacetylases

Lee, H. Y., Wang, L. T., Li, Y. H., Pan, S. L., Chen, Y. L., Teng, C. M. & Liou, J. P., Nov 28 2014, In : Organic and Biomolecular Chemistry. 12, 44, p. 8966-8976 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Expression of glypican 3 enriches hepatocellular carcinoma development-related genes and associates with carcinogenesis in cirrhotic livers

Liu, X., Wang, S. K., Zhang, K., Zhang, H., Pan, Q., Liu, Z., Pan, H., Xue, L., Yen, Y. & Chu, P. G., Aug 20 2014, In : Carcinogenesis. 36, 2, p. 232-242 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Frequent overexpression of HMGA2 in human atypical teratoid/rhabdoid tumor and its correlation with let-7a3/let-7b miRNA

Zhang, K., Gao, H., Wu, X., Wang, J., Zhou, W., Sun, G., Wang, J., Wang, Y., Mu, B., Kim, C., Chu, P., Ho, D. M., Ann, D. K., Wong, T. T. & Yen, Y., 2014, In : Clinical Cancer Research. 20, 5, p. 1179-1189 11 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Increased levels of circulating advanced glycation end-products in menopausal women with osteoporosis

Yang, D. H., Chiang, T. I., Chang, I. C., Lin, F. H., Wei, C. C. & Cheng, Y. W., 2014, In : International Journal of Medical Sciences. 11, 4, p. 453-460 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

In vitro and in vivo anti-tumour effects of MPT0B014, a novel derivative aroylquinoline, and in combination with erlotinib in human non-small-cell lung cancer cells

Tsai, A. C., Pai, H. C., Wang, C. Y., Liou, J. P., Teng, C. M., Wang, J. C. & Pan, S. L., Jan 2014, In : British Journal of Pharmacology. 171, 1, p. 122-133 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Jejunal Cancer with WRN Mutation Identified from Next-Generation Sequencing: A Case Study and Minireview

Chang, C., Shiah, H-S., Hsu, N-Y., Huang, H. Y., Chu, J-S. & Yen, Y., 2014, In : Case Reports in Surgery.

Research output: Contribution to journalArticle

LKB1 Loss at Transcriptional Level Promotes Tumor Malignancy and Poor Patient Outcomes in Colorectal Cancer

He, T. Y., Tsai, L. H., Huang, C. C., Chou, M. C. & Lee, H., 2014, In : Annals of Surgical Oncology. 21, 4, p. 703-710 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

LKB1 loss by alteration of the NKX2-1/p53 pathway promotes tumor malignancy and predicts poor survival and relapse in lung adenocarcinomas

Tsai, L. H., Chen, P. M., Cheng, Y. W., Chen, C. Y., Sheu, G. T., Wu, T. C. & Lee, H., Jul 17 2014, In : Oncogene. 33, 29, p. 3851-3860 10 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Loss of EGFR signaling regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance

Siu, M. K., Abou-Kheir, W., Yin, J. J., Chang, Y. S., Barrett, B., Suau, F., Casey, O., Chen, W. Y., Fang, L., Hynes, P., Hsieh, Y. Y., Liu, Y. N., Huang, J. & Kelly, K., 2014, In : Oncotarget. 5, 11, p. 3770-3784 15 p.

Research output: Contribution to journalArticle

Open Access
41 Citations (Scopus)

Low/negative expression of DDX3 might predict poor prognosis in non-smoker patients with oral cancer

Lee, C. H., Lin, S. H., Yang, S. F., Yang, S. M., Chen, M. K., Lee, H., Ko, J. L., Chen, C. J. & Yeh, K. T., Jan 2014, In : Oral Diseases. 20, 1, p. 76-83 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Metabolism and mis-metabolism of the neuropathological signature protein TDP-43

Huang, C. C., Bose, J. K., Majumder, P., Lee, K. H., Huang, J. T. J., Huang, J. K. & Shen, C. K. J., 2014, In : Journal of Cell Science. 127, 14, p. 3024-3038 15 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

MicroRNA-18a is elevated in prostate cancer and promotes tumorigenesis through suppressing STK4 in vitro and in vivo

Hsu, T. I., Hsu, C. H., Lee, K. H., Lin, J. T., Chen, C. S., Chang, K. C., Su, C. Y. J., Hsiao, M. & Lu, P. J., Jan 1 2014, In : Oncogenesis. 3, 4, e99.

Research output: Contribution to journalArticle

58 Citations (Scopus)

MicroRNA-21 promotes tumour malignancy via increased nuclear translocation of β-catenin and predicts poor outcome in APC-mutated but not in APC-wild-type colorectal cancer

Lin, P. L., Wu, D. W., Huang, C. C., He, T. Y., Chou, M. C., Sheu, G. T. & Lee, H., Oct 1 2014, In : Carcinogenesis. 35, 10, p. 2175-2182 8 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

MicroRNA-224 suppresses colorectal cancer cell migration by targeting Cdc42

Ke, T. W., Hsu, H. L., Wu, Y. H., Chen, W. T. L., Cheng, Y. W. & Cheng, C. W., 2014, In : Disease Markers. 2014, 617150.

Research output: Contribution to journalArticle

37 Citations (Scopus)

MicroRNA-296-5p (miR-296-5p) functions as a tumor suppressor in prostate cancer by directly targeting Pin1

Lee, K. H., Lin, F. C., Hsu, T. I., Lin, J. T., Guo, J. H., Tsai, C. H., Lee, Y. C., Lee, Y. C., Chen, C. L., Hsiao, M. & Lu, P. J., 2014, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1843, 9, p. 2055-2066 12 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

MicroRNA expression profiling in PBMCs: A potential diagnostic biomarker of chronic hepatitis C

Chang, C. C., Lin, C. C., Hsieh, W. L., Lai, H. W., Tsai, C. H. & Cheng, Y. W., 2014, In : Disease Markers. 2014, 367157.

Research output: Contribution to journalArticle

14 Citations (Scopus)

MiR-30 as a tumor suppressor connects EGF/Src signal to ERG and EMT

Kao, C. J., Martiniez, A., Shi, X. B., Yang, J., Evans, C. P., Dobi, A., Devere White, R. W. & Kung, H. J., May 8 2014, In : Oncogene. 33, 19, p. 2495-2503 9 p.

Research output: Contribution to journalArticle

111 Citations (Scopus)