Ph.D. Program for Cancer Molecular Biology and Drug Discovery

  • No. 250 Wu-Xing Street

    11031 Taipei

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2015

Low thyroid hormone levels improve survival in murine model for ocular melanoma

Fabian, I. D., Rosner, M., Fabian, I., Vishnevskia-Dai, V., Zloto, O., Maman, E. S., Cohen, K., Ellis, M., Lin, H. Y., Hercbergs, A., Davis, P. J. & Ashur-Fabian, O., 2015, In : Oncotarget. 6, 13, p. 11038-11046 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Mechanisms of dihydrotestosterone action on resveratrolinduced anti-proliferation in breast cancer cells with different ER status

Chin, Y. T., Yang, S. H., Chang, T. C., Changou, C. A., Lai, H. Y., Fu, E., HuangFu, W. C., Davis, P. J., Lin, H. Y. & Liu, L. F., 2015, In : Oncotarget. 6, 34, p. 35866-35879 14 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

MicroRNA-184 Deregulated by the MicroRNA-21 Promotes Tumor Malignancy and Poor Outcomes in Non-small Cell Lung Cancer via Targeting CDC25A and c-Myc

Lin, T. C., Lin, P. L., Cheng, Y. W., Wu, T. C., Chou, M. C., Chen, C. Y. & Lee, H., Dec 1 2015, In : Annals of Surgical Oncology. 22, p. 1532-1539 8 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

MicroRNA-34a regulates WNT/TCF7 signaling and inhibits bone metastasis in Ras-activated prostate cancer

Chen, W. Y., Liu, S. Y., Chang, Y. S., Yin, J. J., Yeh, H. L., Mouhieddine, T. H., Hadadeh, O., Abou-Kheir, W. & Liu, Y. N., 2015, In : Oncotarget. 6, 1, p. 441-457 17 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

MiR-92a Promotes Cell Metastasis of Colorectal Cancer Through PTEN-Mediated PI3K/AKT Pathway

Ke, T. W., Wei, P. L., Yeh, K. T., Chen, W. T. L. & Cheng, Y. W., Aug 1 2015, In : Annals of Surgical Oncology. 22, 8, p. 2649-2655 7 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

MnSOD overexpression confers cisplatin resistance in lung adenocarcinoma via the NF-κB/Snail/Bcl-2 pathway

Chen, P. M., Cheng, Y. W., Wu, T. C., Chen, C. Y. & Lee, H., 2015, In : Free Radical Biology and Medicine. 79, p. 127-137 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2 Citations (Scopus)

MT-4 suppresses resistant ovarian cancer growth through targeting tubulin and HSP27

Pai, H. C., Kumar, S., Shen, C. C., Liou, J. P., Pan, S. L. & Che, M. T., Apr 14 2015, In : PLoS One. 10, 4, e0123819.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Mutant p53 confers chemoresistance in non-small cell lung cancer by upregulating Nrf2

Tung, M. C., Lin, P. L., Wang, Y. C., He, T. Y., Lee, M. C., Yeh, S. D., Chen, C. Y. & Lee, H., 2015, In : Oncotarget. 6, 39, p. 41692-41705 14 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR-mutated lung cancer via nickel-induced microRNA-21 expression

Chiou, Y. H., Liou, S. H., Wong, R. H., Chen, C. Y. & Lee, H., Aug 9 2015, In : Toxicology Letters. 237, 1, p. 46-54 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

NKX2-1-mediated p53 expression modulates lung adenocarcinoma progression via modulating IKKβ/NF-κB activation

Chen, P. M., Wu, T. C., Cheng, Y. W., Chen, C. Y. & Lee, H., 2015, In : Oncotarget. 6, 16, p. 14274-14289 16 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Novel inhibitors of RANKL-induced osteoclastogenesis: Design, synthesis, and biological evaluation of 6-(2,4-difluorophenyl)-3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-diones

Lee, C. C., Liu, F. L., Chen, C. L., Chen, T. C., Liu, F. C., Ahmed Ali, A. A., Chang, D. M. & Huang, H. S., Jul 23 2015, In : Bioorganic and Medicinal Chemistry. 23, 15, p. 4522-4532 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo

Huang, H-L., Peng, C-Y., Lai, M-J., Chen, C-H., Lee, H. Y., Wang, J-C., Liou, J. P., Pan, S. L. & Teng, C-M., 2015, In : Oncotarget. 6, 7, p. 4976-4991 16 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling

Lai, M-J., Lee, H. Y., Chuang, H-Y., Chang, L-H., Tsai, A-C., Chen, M. C., Huang, H-L., Wu, Y-W., Teng, C-M., Pan, S. L., Liu, Y-M., Mehndiratta, S. & Liou, J. P., Aug 27 2015, In : Journal of Medicinal Chemistry. 58, 16, p. 6549-6558 10 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
10 Citations (Scopus)

Paxillin promotes colorectal tumor invasion and poor patient outcomes via ERK-mediated stabilization of Bcl-2 protein by phosphorylation at Serine 87

Huang, C. C., Wu, D. W., Lin, P. L. & Lee, H., 2015, In : Oncotarget. 6, 11, p. 8698-8708 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Phase i study of nanoliposomal irinotecan (PEP02) in advanced solid tumor patients

Chang, T. C., Shiah, H. S., Yang, C. H., Yeh, K. H., Cheng, A. L., Shen, B. N., Wang, Y. W., Yeh, C. G., Chiang, N. J., Chang, J. Y. & Chen, L. T., Jan 1 2015, In : Cancer Chemotherapy and Pharmacology. 75, 3, p. 579-586 8 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Pyrimidinedione-mediated selective histone deacetylase 6 inhibitors with antitumor activity in colorectal cancer HCT116 cells

Liu, Y-M., Lee, H. Y., Lai, M-J., Pan, S. L., Huang, H-L., Kuo, F-C., Chen, M. C. & Liou, J. P., Aug 17 2015, In : Organic and Biomolecular Chemistry. 13, 40, p. 10226-10235 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Quantitative proteomics reveals middle infrared radiation-interfered networks in breast cancer cells

Chang, H. Y., Li, M. H., Huang, T. C., Hsu, C. L., Tsai, S. R., Lee, S. C., Huang, H. C. & Juan, H. F., Feb 6 2015, In : Journal of Proteome Research. 14, 2, p. 1250-1262 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Quercetin, a main flavonoid in onion, inhibits the PGF-induced uterine contraction in vitro and in vivo

Wu, C. H., Shieh, T. M., Wang, K. L., Huang, T. C. & Hsia, S. M., Dec 1 2015, In : Journal of Functional Foods. 19, p. 495-504 10 p., 1300.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Receptor proteins for nongenomic actions of thyroid hormone

Davis, P. J., Leonard, J. L., Lin, H. Y., Incerpi, S., Luidens, M. K., Tang, H. Y. & Mousa, S. A., Jul 1 2015, In : Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 15, 1, p. 94-97 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Ring fusion strategy for synthesis and lead optimization of sulfur-substituted anthra[1,2-c[[1,2,5]thiadiazole-6,11-dione derivatives as promising scaffold of antitumor agents

Lee, Y. R., Chen, T. C., Lee, C. C., Chen, C. L., Ahmed Ali, A. A., Tikhomirov, A., Guh, J. H., Yu, D. S. & Huang, H. S., Sep 18 2015, In : European Journal of Medicinal Chemistry. 102, p. 661-676 16 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

RRM2B-mediated regulation of mitochondrial activity and inflammation under oxidative stress

Cho, E. C., Kuo, M. L., Cheng, J. H., Cheng, Y. C., Hsieh, Y. C., Liu, Y. R., Hsieh, R. H. & Yen, Y., 2015, In : Mediators of Inflammation. 2015, 287345.

Research output: Contribution to journalArticle

8 Citations (Scopus)

S-adenosyl-L-methionine-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells

Liu, T. P., Lo, H. L., Wei, L. S., Hsiao, H. H. Y. & Yang, P. M., 2015, In : Anti-Cancer Drugs. 26, 2, p. 139-147 9 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Structure-based hybridization, synthesis and biological evaluation of novel tetracyclic heterocyclic azathioxanthone analogues as potential antitumor agents

Chen, T. C., Wu, C. L., Lee, C. C., Chen, C. L., Yu, D. S. & Huang, H. S., Oct 20 2015, In : European Journal of Medicinal Chemistry. 103, p. 615-627 13 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Synthesis and biological evaluation of anthra[1,9-cd]pyrazol-6(2H)-one scaffold derivatives as potential anticancer agents

Chen, T. C., Guh, J. H., Hsu, H. W., Chen, C. L., Lee, C. C., Wu, C. L., Lee, Y. R., Lin, J. J., Yu, D. S. & Huang, H. S., 2015, In : Arabian Journal of Chemistry.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Synthesis and evaluation of new 3-substituted-4-chloro-thioxanthone derivatives as potent anti-breast cancer agents

Chen, C. L., Chen, T. C., Lee, C. C., Shih, L. C., Lin, C. Y., Hsieh, Y. Y., Ali, A. A. A. & Huang, H. S., 2015, In : Arabian Journal of Chemistry.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Targeting of multiple oncogenic signaling pathways by Hsp90 inhibitor alone or in combination with berberine for treatment of colorectal cancer

Su, Y-H., Tang, W. C., Cheng, Y. W., Sia, P., Huang, C. C., Lee, Y. C., Jiang, H. Y., Wu, M. H., Lai, I. L., Lee, J. W. & Lee, K. H., Oct 1 2015, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1853, 10, p. 2261-2272 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

The MZF1/c-MYC axis mediates lung adenocarcinoma progression caused by wild-type lkb1 loss

Tsai, L. H., Wu, J. Y., Cheng, Y. W., Chen, C. Y., Sheu, G. T., Wu, T. C. & Lee, H., Mar 26 2015, In : Oncogene. 34, 13, p. 1641-1649 9 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

The novel ribonucleotide reductase inhibitor COH29 inhibits DNA repair in vitros

Chen, M. C., Zhou, B., Zhang, K., Yuan, Y. C., Un, F., Hu, S., Chou, C. M., Chen, C. H., Wu, J., Wang, Y., Liu, X., Smith, D. L., Li, H., Liu, Z., Warden, C. D., Su, L., Malkas, L. H., Chung, Y. M., Hu, M. C. T. & Yen, Y., Jun 1 2015, In : Molecular Pharmacology. 87, 6, p. 996-1005 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

The pan-PI3K inhibitor GDC-0941 activates canonical WNT signaling to confer resistance in TNBC cells: Resistance reversal with WNT inhibitor

Tzeng, H. E., Yang, L., Chen, K., Wang, Y., Liu, Y. R., Pan, S. L., Gaur, S., Hu, S. & Yen, Y., 2015, In : Oncotarget. 6, 13, p. 11061-11073 13 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

The synergic effect of vincristine and vorinostat in leukemia in vitro and in vivo

Chao, M-W., Lai, M-J., Liou, J. P., Chang, Y-L., Wang, J-C., Pan, S. L. & Teng, C-M., Dec 12 2015, In : Journal of Hematology and Oncology. 8, 1, 176.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Thyroid hormones crosstalk with growth factors: Old facts and new hypotheses

Candelotti, E., Vito, P. D., Ahmed, R. G., Luly, P., Davis, P. J., Pedersen, J. Z., Lin, H. Y. & Incerpi, S., Jul 1 2015, In : Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 15, 1, p. 71-85 15 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Transforming growth factor-β promotes prostate bone metastasis through induction of microRNA-96 and activation of the mTOR pathway

Siu, M. K., Tsai, Y. C., Chang, Y. S., Yin, J. J., Suau, F., Chen, W. Y. & Liu, Y. N., Sep 3 2015, In : Oncogene. 34, 36, p. 4767-4776 10 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Underexpression of LKB1 tumor suppressor is associated with enhanced Wnt signaling and malignant characteristics of human intrahepatic cholangiocarcinoma

Wang, J., Zhang, K., Wang, J., Wu, X., Liu, X., Li, B., Zhu, Y., Yu, Y., Cheng, Q., Hu, Z., Guo, C., Hu, S., Mu, B., Tsai, C. H., Li, J., Smith, L., Yang, L., Liu, Q., Chu, P., Chang, V. & 4 others, Zhang, B., Wu, M., Jiang, X. & Yen, Y., 2015, In : Oncotarget. 6, 22, p. 18905-18920 16 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2014

A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine

Lee, K. H., Lo, H. L., Tang, W. C., Hsiao, H. H. Y. & Yang, P. M., 2014, In : Scientific Reports. 4, 6394.

Research output: Contribution to journalArticle

28 Citations (Scopus)

A germline missense mutation in COQ6 is associated with susceptibility to familial schwannomatosis

Zhang, K., Lin, J. W., Wang, J., Wu, X., Gao, H., Hsieh, Y. C., Hwu, P., Liu, Y. R., Su, L., Chiou, H. Y., Wang, D., Yuan, Y. C., Whang-Peng, J., Chiu, W. T. & Yen, Y., Oct 1 2014, In : Genetics in Medicine. 16, 10, p. 787-792 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

A lytic viral long noncoding RNA modulates the function of a latent protein

Campbell, M., Kim, K. Y., Chang, P. C., Huerta, S., Shevchenko, B., Wang, D. H., Izumiya, C., Kung, H. J. & Izumiya, Y., Feb 1 2014, In : Journal of Virology. 88, 3, p. 1843-1848 6 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis

Chou, C. C., Lee, K. H., Lai, I. L., Wang, D., Mo, X., Kulp, S. K., Shapiro, C. L. & Chen, C. S., Sep 1 2014, In : Cancer Research. 74, 17, p. 4783-4795 13 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)

An improved ChIP-seq peak detection system for simultaneously identifying post-translational modified transcription factors by combinatorial fusion, using SUMOylation as an example

Cheng, C. Y., Chu, C. H., Hsu, H. W., Hsu, F. R., Tang, C. Y., Wang, W. C., Kung, H. J. & Chang, P. C., Jan 24 2014, In : BMC Genomics. 15, p. 1-14 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

A novel action mechanism for MPT0g013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through upregulation of TIMP3 expression

Wang, C-Y., Liou, J. P., Tsai, A-C., Lai, M-J., Liu, Y-M., Lee, H. Y., Wang, J-C., Pan, S. L. & Teng, C-M., 2014, In : Oncotarget. 5, 20, p. 9838-9850 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

A novel class I HDAC inhibitor, MPT0G030, induces cell apoptosis and differentiation in human colorectal cancer cells via HDAC1/PKCδ and E-cadherin

Wang, L. T., Liou, J. P., Li, Y. H., Liu, Y. M., Pan, S. L. & Teng, C. M., 2014, In : Oncotarget. 5, 14, p. 5651-5662 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

A novel compound NSC745885 exerts an anti-tumor effect on tongue cancer SAS cells in vitro and in vivo

Chen, Y. W., Huang, H. S., Shieh, Y. S., Ma, K. H., Huang, S. H., Hueng, D. Y., Sytwu, H. K. & Lin, G. J., Aug 15 2014, In : PLoS One. 9, 8, e104703.

Research output: Contribution to journalArticle

4 Citations (Scopus)
17 Citations (Scopus)

Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro

Chin, Y. T., Hsieh, M. T., Yang, S. H., Tsai, P. W., Wang, S. H., Wang, C. C., Lee, Y. S., Cheng, G. Y., HuangFu, W. C., London, D., Tang, H. Y., Fu, E., Yen, Y., Liu, L. F., Lin, H. Y. & Davis, P. J., 2014, In : Oncotarget. 5, 24, p. 12891-12907 17 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy

Changou, C. A., Chen, Y. R., Xing, L., Yen, Y., Chuang, F. Y. S., Cheng, R. H., Bold, R. J., Ann, D. K. & Kung, H. J., Sep 30 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 39, p. 14147-14152 6 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

AR-regulated TWEAK-FN14 pathway promotes prostate cancer bone metastasis

Yin, J., Liu, Y. N., Tillman, H., Barrett, B., Hewitt, S., Ylaya, K., Fang, L., Lake, R., Corey, E., Morrissey, C., Vessella, R. & Kelly, K., Aug 15 2014, In : Cancer Research. 74, 16, p. 4306-4317 12 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
10 Citations (Scopus)

Autophagy pathway is required for IL-6 induced neuroendocrine differentiation and chemoresistance of prostate cancer LNCaP cells

Chang, P. C., Wang, T. Y., Chang, Y. T., Chu, C. Y., Lee, C. L., Hsu, H. W., Zhou, T. A., Wu, Z., Kim, R. H., Desai, S. J., Liu, S. & Kung, H. J., Feb 14 2014, In : PLoS One. 9, 2, e88556.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Autophagy promotes radiation-induced senescence but inhibits bystander effects in human breast cancer cells

Huang, Y. H., Yang, P. M., Chuah, Q. Y., Lee, Y. J., Hsieh, Y. F., Peng, C. W. & Chiu, S. J., 2014, In : Autophagy. 10, 7, p. 1212-1228 17 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)