Ph.D. Program for Cancer Molecular Biology and Drug Discovery

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output 1996 2020

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Article
2015
4 Citations (Scopus)

Quantitative proteomics reveals middle infrared radiation-interfered networks in breast cancer cells

Chang, H. Y., Li, M. H., Huang, T. C., Hsu, C. L., Tsai, S. R., Lee, S. C., Huang, H. C. & Juan, H. F., Feb 6 2015, In : Journal of Proteome Research. 14, 2, p. 1250-1262 13 p.

Research output: Contribution to journalArticle

Proteomics
Cells
Radiation
Breast Neoplasms
Infrared radiation
2 Citations (Scopus)

Quercetin, a main flavonoid in onion, inhibits the PGF-induced uterine contraction in vitro and in vivo

Wu, C. H., Shieh, T. M., Wang, K. L., Huang, T. C. & Hsia, S. M., Dec 1 2015, In : Journal of Functional Foods. 19, p. 495-504 10 p., 1300.

Research output: Contribution to journalArticle

uterine contraction
Uterine Contraction
Dinoprost
Onions
Quercetin
2 Citations (Scopus)

Receptor proteins for nongenomic actions of thyroid hormone

Davis, P. J., Leonard, J. L., Lin, H. Y., Incerpi, S., Luidens, M. K., Tang, H. Y. & Mousa, S. A., Jul 1 2015, In : Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 15, 1, p. 94-97 4 p.

Research output: Contribution to journalArticle

Thyroid Hormone Receptors
Thyroid Hormones
Cell Membrane
Thyronines
Hormones
12 Citations (Scopus)

Ring fusion strategy for synthesis and lead optimization of sulfur-substituted anthra[1,2-c[[1,2,5]thiadiazole-6,11-dione derivatives as promising scaffold of antitumor agents

Lee, Y. R., Chen, T. C., Lee, C. C., Chen, C. L., Ahmed Ali, A. A., Tikhomirov, A., Guh, J. H., Yu, D. S. & Huang, H. S., Sep 18 2015, In : European Journal of Medicinal Chemistry. 102, p. 661-676 16 p.

Research output: Contribution to journalArticle

Sulfur
Scaffolds
Antineoplastic Agents
Fusion reactions
Apoptosis
7 Citations (Scopus)

RRM2B-mediated regulation of mitochondrial activity and inflammation under oxidative stress

Cho, E. C., Kuo, M. L., Cheng, J. H., Cheng, Y. C., Hsieh, Y. C., Liu, Y. R., Hsieh, R. H. & Yen, Y., 2015, In : Mediators of Inflammation. 2015, 287345.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Oxidative Stress
Inflammation
Mitochondrial Genes
DNA Damage
27 Citations (Scopus)

S-adenosyl-L-methionine-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells

Liu, T. P., Lo, H. L., Wei, L. S., Hsiao, H. H. Y. & Yang, P. M., 2015, In : Anti-Cancer Drugs. 26, 2, p. 139-147 9 p.

Research output: Contribution to journalArticle

S-Adenosylmethionine
Autophagy
Pharmaceutical Preparations
Neoplasms
Antineoplastic Agents
16 Citations (Scopus)

Structure-based hybridization, synthesis and biological evaluation of novel tetracyclic heterocyclic azathioxanthone analogues as potential antitumor agents

Chen, T. C., Wu, C. L., Lee, C. C., Chen, C. L., Yu, D. S. & Huang, H. S., Oct 20 2015, In : European Journal of Medicinal Chemistry. 103, p. 615-627 13 p.

Research output: Contribution to journalArticle

Antineoplastic Agents
Inhibitory Concentration 50
Assays
Cytostatic Agents
Caspase 3

Synthesis and biological evaluation of anthra[1,9-cd]pyrazol-6(2H)-one scaffold derivatives as potential anticancer agents

Chen, T. C., Guh, J. H., Hsu, H. W., Chen, C. L., Lee, C. C., Wu, C. L., Lee, Y. R., Lin, J. J., Yu, D. S. & Huang, H. S., 2015, In : Arabian Journal of Chemistry.

Research output: Contribution to journalArticle

Scaffolds
Antineoplastic Agents
Cells
Derivatives
losoxantrone
1 Citation (Scopus)

Synthesis and evaluation of new 3-substituted-4-chloro-thioxanthone derivatives as potent anti-breast cancer agents

Chen, C. L., Chen, T. C., Lee, C. C., Shih, L. C., Lin, C. Y., Hsieh, Y. Y., Ali, A. A. A. & Huang, H. S., 2015, In : Arabian Journal of Chemistry.

Research output: Contribution to journalArticle

Cells
Derivatives
thioxanthone
Screening
Molecules
21 Citations (Scopus)

Targeting of multiple oncogenic signaling pathways by Hsp90 inhibitor alone or in combination with berberine for treatment of colorectal cancer

Su, Y-H., Tang, W. C., Cheng, Y. W., Sia, P., Huang, C. C., Lee, Y. C., Jiang, H. Y., Wu, M. H., Lai, I. L., Lee, J. W. & Lee, K. H., Oct 1 2015, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1853, 10, p. 2261-2272 12 p.

Research output: Contribution to journalArticle

Berberine
HSP90 Heat-Shock Proteins
Colorectal Neoplasms
Chemical Databases
Catenins
31 Citations (Scopus)

The MZF1/c-MYC axis mediates lung adenocarcinoma progression caused by wild-type lkb1 loss

Tsai, L. H., Wu, J. Y., Cheng, Y. W., Chen, C. Y., Sheu, G. T., Wu, T. C. & Lee, H., Mar 26 2015, In : Oncogene. 34, 13, p. 1641-1649 9 p.

Research output: Contribution to journalArticle

Phosphotransferases
Liver
Neoplasms
Adenocarcinoma of lung
Mutation
11 Citations (Scopus)

The novel ribonucleotide reductase inhibitor COH29 inhibits DNA repair in vitros

Chen, M. C., Zhou, B., Zhang, K., Yuan, Y. C., Un, F., Hu, S., Chou, C. M., Chen, C. H., Wu, J., Wang, Y., Liu, X., Smith, D. L., Li, H., Liu, Z., Warden, C. D., Su, L., Malkas, L. H., Chung, Y. M., Hu, M. C. T. & Yen, Y., Jun 1 2015, In : Molecular Pharmacology. 87, 6, p. 996-1005 10 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
DNA Repair
DNA Damage
gemcitabine
Deoxyribonucleotides
19 Citations (Scopus)

The pan-PI3K inhibitor GDC-0941 activates canonical WNT signaling to confer resistance in TNBC cells: Resistance reversal with WNT inhibitor

Tzeng, H. E., Yang, L., Chen, K., Wang, Y., Liu, Y. R., Pan, S. L., Gaur, S., Hu, S. & Yen, Y., 2015, In : Oncotarget. 6, 13, p. 11061-11073 13 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Phosphatidylinositol 3-Kinases
beta Catenin
MCF-7 Cells
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
26 Citations (Scopus)

The synergic effect of vincristine and vorinostat in leukemia in vitro and in vivo

Chao, M-W., Lai, M-J., Liou, J. P., Chang, Y-L., Wang, J-C., Pan, S. L. & Teng, C-M., Dec 12 2015, In : Journal of Hematology and Oncology. 8, 1, 176.

Research output: Contribution to journalArticle

Vincristine
Leukemia
Microtubules
Tubulin
Cell Survival
9 Citations (Scopus)

Thyroid hormones crosstalk with growth factors: Old facts and new hypotheses

Candelotti, E., Vito, P. D., Ahmed, R. G., Luly, P., Davis, P. J., Pedersen, J. Z., Lin, H. Y. & Incerpi, S., Jul 1 2015, In : Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 15, 1, p. 71-85 15 p.

Research output: Contribution to journalArticle

Thyroid Hormones
Intercellular Signaling Peptides and Proteins
Integrins
Interleukins
Cell Membrane
50 Citations (Scopus)

Transforming growth factor-β promotes prostate bone metastasis through induction of microRNA-96 and activation of the mTOR pathway

Siu, M. K., Tsai, Y. C., Chang, Y. S., Yin, J. J., Suau, F., Chen, W. Y. & Liu, Y. N., Sep 3 2015, In : Oncogene. 34, 36, p. 4767-4776 10 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Sirolimus
MicroRNAs
Prostate
Neoplasm Metastasis
22 Citations (Scopus)

Underexpression of LKB1 tumor suppressor is associated with enhanced Wnt signaling and malignant characteristics of human intrahepatic cholangiocarcinoma

Wang, J., Zhang, K., Wang, J., Wu, X., Liu, X., Li, B., Zhu, Y., Yu, Y., Cheng, Q., Hu, Z., Guo, C., Hu, S., Mu, B., Tsai, C. H., Li, J., Smith, L., Yang, L., Liu, Q., Chu, P., Chang, V. & 4 others, Zhang, B., Wu, M., Jiang, X. & Yen, Y., 2015, In : Oncotarget. 6, 22, p. 18905-18920 16 p.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Phosphotransferases
Liver
Catenins
Neoplasms
2014
27 Citations (Scopus)

A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine

Lee, K. H., Lo, H. L., Tang, W. C., Hsiao, H. H. Y. & Yang, P. M., 2014, In : Scientific Reports. 4, 6394.

Research output: Contribution to journalArticle

Berberine
Herbal Medicine
Transcriptome
Histone Deacetylases
Sirolimus
12 Citations (Scopus)

A germline missense mutation in COQ6 is associated with susceptibility to familial schwannomatosis

Zhang, K., Lin, J. W., Wang, J., Wu, X., Gao, H., Hsieh, Y. C., Hwu, P., Liu, Y. R., Su, L., Chiou, H. Y., Wang, D., Yuan, Y. C., Whang-Peng, J., Chiu, W. T. & Yen, Y., Oct 1 2014, In : Genetics in Medicine. 16, 10, p. 787-792 6 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Missense Mutation
coenzyme Q10
Genome
Exome
39 Citations (Scopus)

A lytic viral long noncoding RNA modulates the function of a latent protein

Campbell, M., Kim, K. Y., Chang, P. C., Huerta, S., Shevchenko, B., Wang, D. H., Izumiya, C., Kung, H. J. & Izumiya, Y., Feb 1 2014, In : Journal of Virology. 88, 3, p. 1843-1848 6 p.

Research output: Contribution to journalArticle

nuclear antigens
Long Noncoding RNA
Human herpesvirus 8
Human Herpesvirus 8
plasmids
93 Citations (Scopus)

AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis

Chou, C. C., Lee, K. H., Lai, I. L., Wang, D., Mo, X., Kulp, S. K., Shapiro, C. L. & Chen, C. S., Sep 1 2014, In : Cancer Research. 74, 17, p. 4783-4795 13 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Epithelial-Mesenchymal Transition
Phenotype
Neoplasms
Ubiquitin-Protein Ligases
3 Citations (Scopus)

An improved ChIP-seq peak detection system for simultaneously identifying post-translational modified transcription factors by combinatorial fusion, using SUMOylation as an example

Cheng, C. Y., Chu, C. H., Hsu, H. W., Hsu, F. R., Tang, C. Y., Wang, W. C., Kung, H. J. & Chang, P. C., Jan 24 2014, In : BMC Genomics. 15, p. 1-14 14 p.

Research output: Contribution to journalArticle

Sumoylation
Chromatin Immunoprecipitation
Transcription Factors
Binding Sites
Post Translational Protein Processing
7 Citations (Scopus)

A novel action mechanism for MPT0g013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through upregulation of TIMP3 expression

Wang, C-Y., Liou, J. P., Tsai, A-C., Lai, M-J., Liu, Y-M., Lee, H. Y., Wang, J-C., Pan, S. L. & Teng, C-M., 2014, In : Oncotarget. 5, 20, p. 9838-9850 13 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-3
Up-Regulation
Neoplasms
Cell Cycle Resting Phase
Proteins
22 Citations (Scopus)

A novel class I HDAC inhibitor, MPT0G030, induces cell apoptosis and differentiation in human colorectal cancer cells via HDAC1/PKCδ and E-cadherin

Wang, L. T., Liou, J. P., Li, Y. H., Liu, Y. M., Pan, S. L. & Teng, C. M., 2014, In : Oncotarget. 5, 14, p. 5651-5662 12 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Cadherins
Protein Kinase C
Cell Differentiation
Colorectal Neoplasms
4 Citations (Scopus)

A novel compound NSC745885 exerts an anti-tumor effect on tongue cancer SAS cells in vitro and in vivo

Chen, Y. W., Huang, H. S., Shieh, Y. S., Ma, K. H., Huang, S. H., Hueng, D. Y., Sytwu, H. K. & Lin, G. J., Aug 15 2014, In : PLoS One. 9, 8, e104703.

Research output: Contribution to journalArticle

Tongue Neoplasms
tongue
Doxorubicin
Tumors
Anthracyclines
17 Citations (Scopus)
Histone Deacetylases
Human Activities
Refractory materials
Prostatic Neoplasms
Display devices
42 Citations (Scopus)

Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro

Chin, Y. T., Hsieh, M. T., Yang, S. H., Tsai, P. W., Wang, S. H., Wang, C. C., Lee, Y. S., Cheng, G. Y., HuangFu, W. C., London, D., Tang, H. Y., Fu, E., Yen, Y., Liu, L. F., Lin, H. Y. & Davis, P. J., 2014, In : Oncotarget. 5, 24, p. 12891-12907 17 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Gene Expression
Stilbenes
Cell Proliferation
Perfusion
52 Citations (Scopus)

Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy

Changou, C. A., Chen, Y. R., Xing, L., Yen, Y., Chuang, F. Y. S., Cheng, R. H., Bold, R. J., Ann, D. K. & Kung, H. J., Sep 30 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 39, p. 14147-14152 6 p.

Research output: Contribution to journalArticle

Autophagy
Starvation
Chromatin
Arginine
DNA
20 Citations (Scopus)

AR-regulated TWEAK-FN14 pathway promotes prostate cancer bone metastasis

Yin, J., Liu, Y. N., Tillman, H., Barrett, B., Hewitt, S., Ylaya, K., Fang, L., Lake, R., Corey, E., Morrissey, C., Vessella, R. & Kelly, K., Aug 15 2014, In : Cancer Research. 74, 16, p. 4306-4317 12 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Androgen Receptors
Prostatic Neoplasms
Neoplasm Metastasis
Bone and Bones
10 Citations (Scopus)
Sirolimus
Human Activities
Prostatic Neoplasms
Phosphotransferases
Hormones
34 Citations (Scopus)

Autophagy pathway is required for IL-6 induced neuroendocrine differentiation and chemoresistance of prostate cancer LNCaP cells

Chang, P. C., Wang, T. Y., Chang, Y. T., Chu, C. Y., Lee, C. L., Hsu, H. W., Zhou, T. A., Wu, Z., Kim, R. H., Desai, S. J., Liu, S. & Kung, H. J., Feb 14 2014, In : PLoS One. 9, 2, e88556.

Research output: Contribution to journalArticle

autophagy
Autophagy
prostatic neoplasms
interleukin-6
Interleukin-6
25 Citations (Scopus)

Autophagy promotes radiation-induced senescence but inhibits bystander effects in human breast cancer cells

Huang, Y. H., Yang, P. M., Chuah, Q. Y., Lee, Y. J., Hsieh, Y. F., Peng, C. W. & Chiu, S. J., 2014, In : Autophagy. 10, 7, p. 1212-1228 17 p.

Research output: Contribution to journalArticle

Bystander Effect
Autophagy
Radiation
Breast Neoplasms
Neoplasms
21 Citations (Scopus)

A vaccine targeted at CETP alleviates high fat and high cholesterol diet-induced atherosclerosis and non-alcoholic steatohepatitis in rabbit

Liaw, Y. W., Lin, C. Y., Lai, Y. S., Yang, T. C., Wang, C. J., Whang-Peng, J., Liu, L. F., Lin, C. P., Nieh, S., Lu, S. C. & Hwang, J., Dec 8 2014, In : PLoS One. 9, 12, e111529.

Research output: Contribution to journalArticle

cholesteryl ester transfer protein
Cholesterol Ester Transfer Proteins
High Fat Diet
Fatty Liver
high fat diet
33 Citations (Scopus)

Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells

Lee, H. Y., Tsai, A. C., Chen, M. C., Shen, P. J., Cheng, Y. C., Kuo, C. C., Pan, S. L., Liu, Y. M., Liu, J. F., Yeh, T. K., Wang, J. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., May 22 2014, In : Journal of Medicinal Chemistry. 57, 10, p. 4009-4022 14 p.

Research output: Contribution to journalArticle

HCT116 Cells
Histone Deacetylases
Colorectal Neoplasms
Histone Deacetylase Inhibitors
Heterografts
24 Citations (Scopus)

Berberis libanotica ehrenb extract shows anti-neoplastic effects on prostate cancer stem/progenitor cells

El-Merahbi, R., Liu, Y. N., Eid, A., Daoud, G., Hosry, L., Monzer, A., Mouhieddine, T. H., Hamade, A., Najjar, F. & Abou-Kheir, W., Nov 7 2014, In : PLoS One. 9, 11, e112453.

Research output: Contribution to journalArticle

Berberis
Neoplastic Stem Cells
prostatic neoplasms
Stem cells
stem cells
8 Citations (Scopus)

Biologically active leptin-related synthetic peptides activate STAT3 via phosphorylation of ERK1/2 and PI-3K

Lin, H. Y., Yang, S. H., Tang, H. Y., Cheng, G. Y., Davis, P. J. & Grasso, P., 2014, In : Peptides. 57, p. 95-100 6 p.

Research output: Contribution to journalArticle

Phosphorylation
Leptin
Phosphatidylinositol 3-Kinases
Chemical activation
Signal transduction
63 Citations (Scopus)

Cancer: Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells

Qiu, F., Chen, Y. R., Liu, X., Chu, C. Y., Shen, L. J., Xu, J., Gaur, S., Forman, H. J., Zhang, H., Zheng, S., Yen, Y., Huang, J., Kung, H. J. & Ann, D. K., Apr 1 2014, In : Science Signaling. 7, 319

Research output: Contribution to journalArticle

Argininosuccinate Synthase
Starvation
Arginine
Cells
Breast Neoplasms
6 Citations (Scopus)

Cell-autonomous heparanase modulates self-renewal and migration in bone marrow-derived mesenchymal stem cells

Cheng, C. C., Lee, Y. H., Lin, S. P., Huangfu, W. C. & Liu, I. H., Mar 13 2014, In : Journal of Biomedical Science. 21, 1, 21.

Research output: Contribution to journalArticle

Stem cells
Mesenchymal Stromal Cells
Bone
Bone Marrow
Heparitin Sulfate
10 Citations (Scopus)

Circulating anti-cyclic citrullinated peptide antibody in patients with rheumatoid arthritis and chronic obstructive pulmonary disease

Yang, D. H., Tu, C. C., Wang, S. C., Wei, C. C. & Cheng, Y. W., 2014, In : Rheumatology International. 34, 7, p. 971-977 7 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Rheumatoid Arthritis
Antibodies
Rheumatoid Factor
Smoking
2 Citations (Scopus)

Clinical research of mortality in emergency air medical transport

Chen, W. L., Ma, H. P., Wu, C. H., Chiou, H. Y., Yen, Y., Chiu, W. T. & Tsai, S. H., 2014, In : BioMed Research International. 2014, 767402.

Research output: Contribution to journalArticle

Health care
Emergencies
Air
Mortality
Taiwan
45 Citations (Scopus)

C-Myc suppresses microRNA-29b to promote tumor aggressiveness and poor outcomes in non-small cell lung cancer by targeting FHIT

Wu, D. W., Hsu, N. Y., Wang, Y. C., Lee, M. C., Cheng, Y. W., Chen, C. Y. & Lee, H., Jun 9 2014, In : Oncogene. 34, 16, p. 2072-2082 11 p.

Research output: Contribution to journalArticle

MicroRNAs
Non-Small Cell Lung Carcinoma
Neoplasms
Survival
Agar
14 Citations (Scopus)

Combination therapy targeting ectopic ATP synthase and 26S proteasome induces ER stress in breast cancer cells

Chang, H. Y., Huang, T. C., Chen, N. N., Huang, H. C. & Juan, H. F., Jan 1 2014, In : Cell Death and Disease. 5, 11, e1540.

Research output: Contribution to journalArticle

Adenosine Triphosphate
Breast Neoplasms
Proteasome Inhibitors
Cyclin D3
Therapeutics
156 Citations (Scopus)

Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA

Zuckerman, J. E., Gritli, I., Tolcher, A., Heidel, J. D., Lim, D., Morgan, R., Chmielowski, B., Ribas, A., Davis, M. E. & Yen, Y., Aug 5 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 31, p. 11449-11454 6 p.

Research output: Contribution to journalArticle

Nanoparticles
Small Interfering RNA
Polymers
Clinical Trials, Phase I
RNA Interference

Curative use of forequarter amputation for recurrent breast cancer over an axillary area: a case report and literature review

Tsai, C. H., Tzeng, H. E., Juang, W. K., Chu, P. G., Fann, P., Fong, Y. C., Hsu, H. C. & Yen, Y., 2014, In : World Journal of Surgical Oncology. 12, p. 346 1 p.

Research output: Contribution to journalArticle

Amputation
Breast Neoplasms
Recurrence
Neoplasm Metastasis
Upper Extremity
56 Citations (Scopus)

DDX3 loss by p53 inactivation promotes tumor malignancy via the MDM2/Slug/E-cadherin pathway and poor patient outcome in non-small-cell lung cancer

Wu, D. W., Lee, M. C., Wang, J., Chen, C. Y., Cheng, Y. W. & Lee, H., Mar 20 2014, In : Oncogene. 33, 12, p. 1515-1526 12 p.

Research output: Contribution to journalArticle

Gastropoda
Cadherins
Non-Small Cell Lung Carcinoma
Neoplasms
Lung Neoplasms
37 Citations (Scopus)

Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents

Wang, M. J., Liu, Y. Q., Chang, L. C., Wang, C. Y., Zhao, Y. L., Zhao, X. B., Qian, K., Nan, X., Yang, L., Yang, X. M., Hung, H. Y., Yang, J. S., Kuo, D. H., Goto, M., Morris-Natschke, S. L., Pan, S. L., Teng, C. M., Kuo, S. C., Wu, T. S., Wu, Y. C. & 1 others, Lee, K. H., Jul 24 2014, In : Journal of Medicinal Chemistry. 57, 14, p. 6008-6018 11 p.

Research output: Contribution to journalArticle

Camptothecin
Type I DNA Topoisomerase
irinotecan
Lethal Dose 50
Antineoplastic Agents
20 Citations (Scopus)

Dovitinib synergizes with oxaliplatin in suppressing cell proliferation and inducing apoptosis in colorectal cancer cells regardless of RAS-RAF mutation status

Gaur, S., Chen, L., Ann, V., Lin, W. C., Wang, Y., Chang, V. H. S., Hsu, N. Y., Shia, H. S. & Yen, Y., Feb 4 2014, In : Molecular Cancer. 13, 1, 21.

Research output: Contribution to journalArticle

oxaliplatin
Colorectal Neoplasms
Cell Proliferation
Heterografts
Colonic Neoplasms
5 Citations (Scopus)

Effect of C7-substitution of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines on the selectivity towards a subclass of histone deacetylases

Lee, H. Y., Wang, L. T., Li, Y. H., Pan, S. L., Chen, Y. L., Teng, C. M. & Liou, J. P., Nov 28 2014, In : Organic and Biomolecular Chemistry. 12, 44, p. 8966-8976 11 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Tumors
Substitution reactions
selectivity
substitutes
15 Citations (Scopus)

Expression of glypican 3 enriches hepatocellular carcinoma development-related genes and associates with carcinogenesis in cirrhotic livers

Liu, X., Wang, S. K., Zhang, K., Zhang, H., Pan, Q., Liu, Z., Pan, H., Xue, L., Yen, Y. & Chu, P. G., Aug 20 2014, In : Carcinogenesis. 36, 2, p. 232-242 11 p.

Research output: Contribution to journalArticle

Glypicans
Hepatocellular Carcinoma
Carcinogenesis
Liver
Genes
24 Citations (Scopus)

Frequent overexpression of HMGA2 in human atypical teratoid/rhabdoid tumor and its correlation with let-7a3/let-7b miRNA

Zhang, K., Gao, H., Wu, X., Wang, J., Zhou, W., Sun, G., Wang, J., Wang, Y., Mu, B., Kim, C., Chu, P., Ho, D. M., Ann, D. K., Wong, T. T. & Yen, Y., 2014, In : Clinical Cancer Research. 20, 5, p. 1179-1189 11 p.

Research output: Contribution to journalArticle

AT-Hook Motifs
MicroRNAs
Oncogene Proteins
Immunohistochemistry
Typical Teratoid Rhabdoid Tumor