Ph.D. Program for Cancer Molecular Biology and Drug Discovery

  • No. 250 Wu-Xing Street

    11031 Taipei

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Loss of TIMP-3 promotes tumor invasion via elevated IL-6 production and predicts poor survival and relapse in HPV-infected non-small cell lung cancer

Wu, D. W., Tsai, L. H., Chen, P. M., Lee, M. C., Wang, L., Chen, C. Y., Cheng, Y. W. & Lee, H., Nov 2012, In : American Journal of Pathology. 181, 5, p. 1796-1806 11 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Lovastatin overcomes gefitinib resistance through TNF-a signaling in human cholangiocarcinomas with different LKB1 statuses in vitro and in vivo

Yang, S. H., Lin, H. Y., Chang, V. H. S., Chen, C. C., Liu, Y. R., Wang, J., Zhang, K., Jiang, X. & Yen, Y., 2015, In : Oncotarget. 6, 27, p. 23857-23873 17 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Low/negative expression of DDX3 might predict poor prognosis in non-smoker patients with oral cancer

Lee, C. H., Lin, S. H., Yang, S. F., Yang, S. M., Chen, M. K., Lee, H., Ko, J. L., Chen, C. J. & Yeh, K. T., Jan 2014, In : Oral Diseases. 20, 1, p. 76-83 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Lowered circulating aspartate is a metabolic feature of human breast cancer

Xie, G., Zhou, B., Zhao, A., Qiu, Y., Zhao, X., Garmire, L., Shvetsov, Y. B., Yu, H., Yen, Y. & Jia, W., Jan 1 2015, In : Oncotarget. 6, 32, p. 33369-33381 13 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Low thyroid hormone levels improve survival in murine model for ocular melanoma

Fabian, I. D., Rosner, M., Fabian, I., Vishnevskia-Dai, V., Zloto, O., Maman, E. S., Cohen, K., Ellis, M., Lin, H. Y., Hercbergs, A., Davis, P. J. & Ashur-Fabian, O., 2015, In : Oncotarget. 6, 13, p. 11038-11046 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

LTP-1, a novel antimitotic agent and Stat3 inhibitor, inhibits human pancreatic carcinomas in vitro and in vivo

Huang, H. L., Chao, M. W., Chen, C. C., Cheng, C. C., Chen, M. C., Lin, C. F., Liou, J. P., Teng, C. M. & Pan, S. L., Jun 9 2016, In : Scientific Reports. 6, 27794.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Machine learning–based radiomics for molecular subtyping of gliomas

Lu, C-F., Hsu, F-T., Hsieh, KL-C., Kao, Y-CJ., Cheng, S-J., Hsu, JB-K., Tsai, P-H., Chen, R-J., Huang, C-C., Yen, Y. & Chen, C-Y., Sep 15 2018, In : Clinical Cancer Research. 24, 18, p. 4429-4436 8 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Manzamine a exerts anticancer activity against human colorectal cancer cells

Lin, L. C., Kuo, T. T., Chang, H. Y., Liu, W. S., Hsia, S. M. & Huang, T. C., Jul 29 2018, In : Marine Drugs. 16, 8, 252.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Markers for efficacy of mammalian target of rapamycin inhibitor

Liao, Y. M., Sy, A. & Yen, Y., Oct 2012, In : Anticancer Research. 32, 10, p. 4235-4244 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Mechanism and clinical properties of stembios cell therapy: Induction of early osseointegration in novel dental implants

Weng, C. C., Ou, K. L., Wu, C. Y., Huang, Y. H., Wang, J., Yen, Y., Cheng, H. Y. & Lin, Y. H., 2017, In : International Journal of Oral and Maxillofacial Implants. 32, 1, p. e47-e54

Research output: Contribution to journalArticle

Mechanisms of ceramide-induced COX-2-dependent apoptosis in human ovarian cancer OVCAR-3 cells partially overlapped with resveratrol

Lin, H. Y., Delmas, D., Vang, O., Hsieh, T. C., Lin, S., Cheng, G. Y., Chiang, H. L., Chen, C. E., Tang, H. Y., Crawford, D. R., Whang-Peng, J., Hwang, J., Liu, L. F. & Wu, J. M., Aug 2013, In : Journal of Cellular Biochemistry. 114, 8, p. 1940-1954 15 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Mechanisms of dihydrotestosterone action on resveratrolinduced anti-proliferation in breast cancer cells with different ER status

Chin, Y. T., Yang, S. H., Chang, T. C., Changou, C. A., Lai, H. Y., Fu, E., HuangFu, W. C., Davis, P. J., Lin, H. Y. & Liu, L. F., 2015, In : Oncotarget. 6, 34, p. 35866-35879 14 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Melatonin activates cell death programs for the suppression of uterine leiomyoma cell proliferation

Lin, P. H., Tung, Y. T., Chen, H. Y., Chiang, Y. F., Hong, H. C., Huang, K. C., Hsu, S. P., Huang, T. C. & Hsia, S. M., Jan 1 2020, In : Journal of Pineal Research. 68, 1, p. e12620 e12620.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Metabolism and mis-metabolism of the neuropathological signature protein TDP-43

Huang, C. C., Bose, J. K., Majumder, P., Lee, K. H., Huang, J. T. J., Huang, J. K. & Shen, C. K. J., 2014, In : Journal of Cell Science. 127, 14, p. 3024-3038 15 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Methyl Protodioscin, a Steroidal Saponin, Inhibits Neointima Formation in Vitro and in Vivo

Chung, Y. L., Pan, C. H., Wang, C. C. N., Hsu, K. C., Sheu, M. J., Chen, H. F. & Wu, C. H., Jun 24 2016, In : Journal of Natural Products. 79, 6, p. 1635-1644 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

MicroRNA-184 Deregulated by the MicroRNA-21 Promotes Tumor Malignancy and Poor Outcomes in Non-small Cell Lung Cancer via Targeting CDC25A and c-Myc

Lin, T. C., Lin, P. L., Cheng, Y. W., Wu, T. C., Chou, M. C., Chen, C. Y. & Lee, H., Dec 1 2015, In : Annals of Surgical Oncology. 22, p. 1532-1539 8 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

MicroRNA-18a is elevated in prostate cancer and promotes tumorigenesis through suppressing STK4 in vitro and in vivo

Hsu, T. I., Hsu, C. H., Lee, K. H., Lin, J. T., Chen, C. S., Chang, K. C., Su, C. Y. J., Hsiao, M. & Lu, P. J., Jan 1 2014, In : Oncogenesis. 3, 4, e99.

Research output: Contribution to journalArticle

59 Citations (Scopus)

MicroRNA-19a and microRNA-19b promote the malignancy of clear cell renal cell carcinoma through targeting the tumor suppressor RhoB

Niu, S., Ma, X., Zhang, Y., Liu, Y. N., Chen, X., Gong, H., Yao, Y., Liu, K. & Zhang, X., Feb 1 2018, In : PLoS One. 13, 2, e0192790.

Research output: Contribution to journalArticle

19 Citations (Scopus)

MicroRNA-21 promotes tumour malignancy via increased nuclear translocation of β-catenin and predicts poor outcome in APC-mutated but not in APC-wild-type colorectal cancer

Lin, P. L., Wu, D. W., Huang, C. C., He, T. Y., Chou, M. C., Sheu, G. T. & Lee, H., Oct 1 2014, In : Carcinogenesis. 35, 10, p. 2175-2182 8 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

MicroRNA-224 suppresses colorectal cancer cell migration by targeting Cdc42

Ke, T. W., Hsu, H. L., Wu, Y. H., Chen, W. T. L., Cheng, Y. W. & Cheng, C. W., 2014, In : Disease Markers. 2014, 617150.

Research output: Contribution to journalArticle

37 Citations (Scopus)

MicroRNA-296-5p (miR-296-5p) functions as a tumor suppressor in prostate cancer by directly targeting Pin1

Lee, K. H., Lin, F. C., Hsu, T. I., Lin, J. T., Guo, J. H., Tsai, C. H., Lee, Y. C., Lee, Y. C., Chen, C. L., Hsiao, M. & Lu, P. J., 2014, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1843, 9, p. 2055-2066 12 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

MicroRNA-320 suppresses the stem cell-like characteristics of prostate cancer cells by downregulating the Wnt/beta-catenin signaling pathway

Hsieh, I. S., Chang, K. C., Tsai, Y. T., Ke, J. Y., Lu, P. J., Lee, K. H., Yeh, S. D., Hong, T. M. & Chen, Y. L., Mar 2013, In : Carcinogenesis. 34, 3, p. 530-538 9 p.

Research output: Contribution to journalArticle

159 Citations (Scopus)

MicroRNA-34a regulates WNT/TCF7 signaling and inhibits bone metastasis in Ras-activated prostate cancer

Chen, W. Y., Liu, S. Y., Chang, Y. S., Yin, J. J., Yeh, H. L., Mouhieddine, T. H., Hadadeh, O., Abou-Kheir, W. & Liu, Y. N., 2015, In : Oncotarget. 6, 1, p. 441-457 17 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

MicroRNA-630 may confer favorable cisplatin-based chemotherapy and clinical outcomes in non-small cell lung cancer by targeting Bcl-2

Chen, M. J., Wu, D. W., Wang, G. C., Wang, Y. C., Chen, C. Y. & Lee, H., 2018, In : Oncotarget. 9, 17, p. 13758-13767 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

MicroRNA-657 promotes tumorigenesis in hepatocellular carcinoma by targeting transducin-like enhancer protein 1 through nuclear factor kappa B pathways

Zhang, L., Yang, L., Liu, X., Chen, W., Chang, L., Chen, L., Loera, S., Chu, P., Huang, W. C., Liu, Y. R. & Yen, Y., May 1 2013, In : Hepatology. 57, 5, p. 1919-1930 12 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

MicroRNA expression profiling in PBMCs: A potential diagnostic biomarker of chronic hepatitis C

Chang, C. C., Lin, C. C., Hsieh, W. L., Lai, H. W., Tsai, C. H. & Cheng, Y. W., 2014, In : Disease Markers. 2014, 367157.

Research output: Contribution to journalArticle

14 Citations (Scopus)

miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2

Chen, H. Y., Lang, Y. D., Lin, H. N., Liu, Y. R., Liao, C. C., Nana, A. W., Yen, Y. & Chen, R. H., Dec 1 2019, In : Scientific Reports. 9, 1, 9687.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

miR-211 regulates the expression of RRM2 in tumoral metastasis and recurrence in colorectal cancer patients with a k-ras gene mutation

Chang, C. C., Lin, C. C., Wang, C. H., Huang, C. C., Ke, T. W., Wei, P. L., Yeh, K. T., Hsu, K. C., Hsu, N. Y. & Cheng, Y. W., May 1 2018, In : Oncology Letters. 15, 5, p. 8107-8117 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

MiR-30 as a tumor suppressor connects EGF/Src signal to ERG and EMT

Kao, C. J., Martiniez, A., Shi, X. B., Yang, J., Evans, C. P., Dobi, A., Devere White, R. W. & Kung, H. J., May 8 2014, In : Oncogene. 33, 19, p. 2495-2503 9 p.

Research output: Contribution to journalArticle

111 Citations (Scopus)

MiR-30c-2* negative regulated MTA-1 expression involved in metastasis and drug resistance of HPV-infected non-small cell lung cancer

Wu, Y. L., Hsu, N-Y., Lin, F. C. F., Lee, H. & Cheng, Y-W., Dec 1 2016, In : Surgery (United States). 160, 6, p. 1591-1598 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

MiR326 maturation is crucial for VEGF-C-driven cortactin expression and esophageal cancer progression

Hong, C. C., Chen, P. S., Chiou, J., Chiu, C. F., Yang, C. Y., Hsiao, M., Chang, Y. W., Yu, Y. H., Hung, M. C., Hsu, N. W., Shiah, S. G., Hsu, N. Y. & Su, J. L., Nov 1 2014, In : Cancer Research. 74, 21, p. 6280-6290 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

MiR-92a Promotes Cell Metastasis of Colorectal Cancer Through PTEN-Mediated PI3K/AKT Pathway

Ke, T. W., Wei, P. L., Yeh, K. T., Chen, W. T. L. & Cheng, Y. W., Aug 1 2015, In : Annals of Surgical Oncology. 22, 8, p. 2649-2655 7 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)

MiRNA-221 negatively regulated downstream p27Kip1 gene expression involvement in pterygium pathogenesis

Wu, C. W., Cheng, Y. W., Hsu, N. Y., Yeh, K. T., Tsai, Y. Y., Chiang, C. C., Wang, W. R. & Tung, J. N., Jul 18 2014, In : Molecular Vision. 20, p. 1048-1056 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy

Owyong, M., Chou, J., van den Bijgaart, R. J. E., Kong, N., Efe, G., Maynard, C., Talmi-Frank, D., Solomonov, I., Koopman, C., Hadler-Olsen, E., Headley, M., Lin, C., Wang, C. Y., Sagi, I., Werb, Z. & Plaks, V., Jan 1 2019, In : Life Science Alliance. 2, 6, e201800226.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

MnSOD overexpression confers cisplatin resistance in lung adenocarcinoma via the NF-κB/Snail/Bcl-2 pathway

Chen, P. M., Cheng, Y. W., Wu, T. C., Chen, C. Y. & Lee, H., 2015, In : Free Radical Biology and Medicine. 79, p. 127-137 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

MnSOD promotes tumor invasion via upregulation of FoxM1-MMP2 axis and related with poor survival and relapse in lung adenocarcinomas

Chen, P. M., Wu, T. C., Shieh, S. H., Wu, Y. H., Li, M. C., Sheu, G. T., Cheng, Y. W., Chen, C. Y. & Lee, H., Mar 2013, In : Molecular Cancer Research. 11, 3, p. 261-271 11 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Modified salicylanilide and 3-phenyl-2 H -benzo[ e ][1,3]oxazine-2,4(3 H)-dione derivatives as novel inhibitors of osteoclast differentiation and bone resorption

Chen, C. L., Liu, F. L., Lee, C. C., Chen, T. C., Ahmed Ali, A. A., Sytwu, H. K., Chang, D. M. & Huang, H. S., Oct 9 2014, In : Journal of Medicinal Chemistry. 57, 19, p. 8072-8085 14 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Modulation of angiogenesis by thyroid hormone and hormone analogues: Implications for cancer management

Mousa, S. A., Lin, H. Y., Tang, H. Y., Hercbergs, A., Luidens, M. K. & Davis, P. J., 2014, In : Angiogenesis. 17, 3, p. 463-469 7 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Molecular mechanisms of actions of formulations of the thyroid hormone analogue, tetrac, on the inflammatory response

Davis, P. J., Glinsky, G. V., Lin, H. Y., Incerpi, S., Davis, F. B., Mousa, S. A., Tang, H. Y., Hercbergs, A. & Luidens, M. K., 2013, In : Endocrine Research. 38, 2, p. 112-118 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
3 Citations (Scopus)

Molybdenum doping effects for bismuth vanadate photocatalysts on electrochemical performances using the solution process

Chen, Y. S., Lin, L. Y. & Lin, H. Y., Jan 1 2020, In : International Journal of Hydrogen Energy. 45, 1, p. 667-674 8 p.

Research output: Contribution to journalArticle

Open Access

Moniliformediquinone induces in vitro and in vivo antitumor activity through glutathione involved DNA damage response and mitochondrial stress in human hormone refractory prostate cancer

Hsu, J. L., Lee, Y. J., Leu, W. J., Dong, Y. S., Pan, S. L., Uang, B. J. & Guh, J. H., 2014, In : Journal of Urology. 191, 5, p. 1429-1438 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo

Tsai, A. C., Pan, S. L., Liao, C. H., Guh, J. H., Wang, S. W., Sun, H. L., Liu, Y. N., Chen, C. C., Shen, C. C., Chang, Y. L. & Teng, C. M., Jun 2010, In : Cancer Letters. 292, 2, p. 163-170 8 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Moscatilin inhibits migration and metastasis of human breast cancer MDA-MB-231 cells through inhibition of Akt and Twist signaling pathway

Pai, H. C., Chang, L. H., Peng, C. Y., Chang, Y. L., Chen, C. C., Shen, C. C., Teng, C. M. & Pan, S. L., Mar 2013, In : Journal of Molecular Medicine. 91, 3, p. 347-356 10 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
7 Citations (Scopus)

MPT0G413, A novel HDAC6-selective inhibitor, and bortezomib synergistically exert anti-tumor activity in multiple myeloma cells

Huang, F. I., Wu, Y. W., Sung, T. Y., Liou, J. P., Lin, M. H., Pan, S. L. & Yang, C. R., Jan 1 2019, In : Frontiers in Oncology. 9, APR, p. 249 249.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

MT-4 suppresses resistant ovarian cancer growth through targeting tubulin and HSP27

Pai, H. C., Kumar, S., Shen, C. C., Liou, J. P., Pan, S. L. & Che, M. T., Apr 14 2015, In : PLoS One. 10, 4, e0123819.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs

Yang, C. P., Yang, W. S., Wong, Y. H., Wang, K. H., Teng, Y. C., Chang, M. H., Liao, K. H., Nian, F. S., Chao, C. C., Tsai, J. W., Hwang, W. L., Lin, M. W., Tzeng, T. Y., Wang, P. N., Campbell, M., Chen, L. K., Tsai, T. F., Chang, P. C. & Kung, H. J., May 1 2020, In : Aging Cell. 19, 5, e13107.

Research output: Contribution to journalArticle

Open Access

Mutant p53 confers chemoresistance in non-small cell lung cancer by upregulating Nrf2

Tung, M. C., Lin, P. L., Wang, Y. C., He, T. Y., Lee, M. C., Yeh, S. D., Chen, C. Y. & Lee, H., 2015, In : Oncotarget. 6, 39, p. 41692-41705 14 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Mutants TP53 p.R273H and p.R273C but not p.R273G Enhance Cancer Cell Malignancy

Li, J., Yang, L., Gaur, S., Zhang, K., Wu, X., Yuan, Y. C., Li, H., Hu, S., Weng, Y. & Yen, Y., Jan 1 2014, In : Human Mutation. 35, 5, p. 575-584 10 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)