Ph.D. Program for Cancer Molecular Biology and Drug Discovery

  • No. 250 Wu-Xing Street

    11031 Taipei

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2016
27 Citations (Scopus)

Paxillin confers resistance to tyrosine kinase inhibitors in EGFR-mutant lung cancers via modulating BIM and Mcl-1 protein stability

Wu, D. W., Chen, C. Y., Chu, C. L. & Lee, H., Feb 4 2016, In : Oncogene. 35, 5, p. 621-630 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Phenyl Benzenesulfonylhydrazides Exhibit Selective Indoleamine 2,3-Dioxygenase Inhibition with Potent in Vivo Pharmacodynamic Activity and Antitumor Efficacy

Lin, S. Y., Yeh, T. K., Kuo, C. C., Song, J. S., Cheng, M. F., Liao, F. Y., Chao, M. W., Huang, H. L., Chen, Y. L., Yang, C. Y., Wu, M. H., Hsieh, C. L., Hsiao, W., Peng, Y. H., Wu, J. S., Lin, L. M., Sun, M., Chao, Y. S., Shih, C., Wu, S. Y. & 3 others, Pan, S. L., Hung, M. S. & Ueng, S. H., Jan 14 2016, In : Journal of Medicinal Chemistry. 59, 1, p. 419-430 12 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Polygonum multiflorum Decreases Airway Allergic Symptoms in a Murine Model of Asthma

Lee, C. C., Lee, Y. L., Wang, C. N., Tsai, H. C., Chiu, C. L., Liu, L. F., Lin, H. Y. & Wu, R., Feb 1 2016, In : American Journal of Chinese Medicine. 44, 1, p. 133-147 15 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Precision Medicine and Pancreatic Cancer

Farrell, J. J., Moughan, J., Wong, J. L., Regine, W. F., Schaefer, P., Benson, A. B., Macdonald, J. S., Liu, X., Yen, Y., Lai, R., Zheng, Z., Bepler, G., Guha, C. & Elsaleh, H., Nov 1 2016, In : Pancreas. 45, 10, p. 1485-1493 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
23 Citations (Scopus)

Primary versus castration-resistant prostate cancer: Modeling through novel murine prostate cancer cell line

Daoud, G., Monzer, A., Bahmad, H., Chamaa, F., Hamdar, L., Mouhieddine, T. H., Shayya, S., Eid, A., Kobeissy, F., Liu, Y. N. & Abou-Kheir, W., May 17 2016, In : Oncotarget. 7, 20, p. 28961-28975 15 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Prognostic and therapeutic value of mitochondrial serine hydroxyl-methyltransferase 2 as a breast cancer biomarker

Zhang, L., Chen, Z., Xue, D., Zhang, Q., Liu, X., Luh, F., Hong, L., Zhang, H., Pan, F., Liu, Y., Chu, P., Zheng, S., Lou, G. & Yen, Y., Nov 1 2016, In : Oncology Reports. 36, 5, p. 2489-2500 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Proton pump inhibitors and risk of periampullary cancers - A nested case-control study

Chien, L-N., Huang, Y. J., Shao, Y-H., Chang, C. J., Chuang, M. T., Chiou, H-Y. & Yen, Y., Mar 15 2016, In : International Journal of Cancer. 138, 6, p. 1401-1409 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Pu-erh Tea Extract Attenuates Nicotine-Induced Foam Cell Formation in Primary Cultured Monocytes: An in Vitro Mechanistic Study

Tu, S. H., Chen, M. Y., Chen, L. C., Mao, Y. T., Ho, C. H., Lee, W. J., Lin, Y-K., Pan, M. H., Lo, C. Y., Chen, C. L., Yen, Y., Whang-Peng, J., Ho, C. T., Wu, C. H. & Ho, Y. S., Apr 27 2016, In : Journal of Agricultural and Food Chemistry. 64, 16, p. 3186-3195 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

PYCR1 and PYCR2 Interact and Collaborate with RRM2B to Protect Cells from Overt Oxidative Stress

Kuo, M. L., Lee, M. B. E., Tang, M., Den Besten, W., Hu, S., Sweredoski, M. J., Hess, S., Chou, C. M., Changou, C. A., Su, M., Jia, W., Su, L. & Yen, Y., Jan 6 2016, In : Scientific Reports. 6, 18846.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Reduction of microRNA-184 by E6 oncoprotein confers cisplatin resistance in lung cancer via increasing Bcl-2

Tung, M. C., Lin, P. L., Cheng, Y. W., Wu, D. W., Yeh, S. D., Chen, C. Y. & Lee, H., May 31 2016, In : Oncotarget. 7, 22, p. 32362-32374 13 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
12 Citations (Scopus)

Research of StemBios cell therapy on dental implants containing nanostructured surfaces: Biomechanical behaviors, microstructural characteristics, and clinical trial

Ou, K. L., Weng, C. C., Wu, C. C., Lin, Y. H., Chiang, H. J., Yang, T. S., Wang, J., Yen, Y., Cheng, H. Y. & Sugiatno, E., Feb 1 2016, In : Implant Dentistry. 25, 1, p. 63-73 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

REST reduction is essential for hypoxia-induced neuroendocrine differentiation of prostate cancer cells by activating autophagy signaling

Lin, T. P., Chang, Y. T., Lee, S. Y., Campbell, M., Wang, T. C., Shen, S. H., Chung, H. J., Chang, Y. H., Chiu, A. W., Pan, C. C., Lin, C. H., Chu, C. Y., Kung, H. J., Cheng, C. Y. & Chang, P. C., May 1 2016, In : Oncotarget. 7, 18, p. 26137-26151 15 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Resveratrol inhibits proliferation of myometrial and leiomyoma cells and decreases extracellular matrix-associated protein expression

Wu, C. H., Shieh, T. M., Wei, L. H., Cheng, T. F., Chen, H. Y., Huang, T. C., Wang, K. L. & Hsia, S. M., May 1 2016, In : Journal of Functional Foods. 23, p. 241-252 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

RINT-1 interacts with MSP58 within nucleoli and plays a role in ribosomal gene transcription

Yang, C. P., Kuo, Y. L., Lee, Y. C., Lee, K. H., Chiang, C. W., Wang, J. M., Hsu, C. C., Chang, W. C. & Lin, D. Y., Sep 16 2016, In : Biochemical and Biophysical Research Communications. 478, 2, p. 873-880 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Selective recognition and stabilization of new ligands targeting the potassium form of the human telomeric G-quadruplex DNA

Lin, Y. H., Chuang, S. M., Wu, P. C., Chen, C. L., Jeyachandran, S., Lo, S. C., Huang, H. S. & Hou, M. H., Aug 11 2016, In : Scientific Reports. 6, 31019.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Signature miRNAs in colorectal cancers were revealed using a bias reduction small RNA deep sequencing protocol

Sun, G., Cheng, Y. W., Lai, L., Huang, T. C., Wang, J., Wu, X., Wang, Y., Huang, Y., Wang, J., Zhang, K., Hu, S., Yang, J. R. & Yen, Y., 2016, In : Oncotarget. 7, 4, p. 3857-3872 16 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Sterol O-acyltransferase 2 contributes to the yolk cholesterol trafficking during zebrafish embryogenesis

Chang, N. Y., Chan, Y. J., Ding, S. T., Lee, Y. H., Huangfu, W. C. & Liu, I. H., Dec 1 2016, In : PLoS One. 11, 12, e0167644.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Systematic discovery of drug action mechanisms by an integrated chemical genomics approach: Identification of functional disparities between azacytidine and decitabine

Hsieh, Y. Y., Huang, T. C., Lo, H. L., Jhan, J. Y., Chen, S. T. & Yang, P. M., May 10 2016, In : Oncotarget. 7, 19, p. 27363-27378 16 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

TC-N19, a novel dual inhibitor of EGFR and cMET, efficiently overcomes EGFR-TKI resistance in non-small-cell lung cancer cells

Wu, D. W., Chen, T. C., Huang, H. S. & Lee, H., Jun 30 2016, In : Cell death & disease. 7, 6, p. e2290

Research output: Contribution to journalArticle

16 Citations (Scopus)

The combination of tetraiodothyroacetic acid and cetuximab inhibits cell proliferation in colorectal cancers with different K-ras status

Lee, Y. S., Chin, Y. T., Yang, Y. C. S. H., Wei, P. L., Wu, H. C., Shih, A., Lu, Y. T., Pedersen, J. Z., Incerpi, S., Liu, L. F., Lin, H. Y. & Davis, P. J., 2016, In : Steroids. p. 63-70

Research output: Contribution to journalArticle

14 Citations (Scopus)

The cytokine-cosmc signaling axis upregulates the tumorassociated carbohydrate antigen Tn

Ho, C. W., Lin, C. Y., Liaw, Y. W., Chiang, H. L., Chin, Y. T., Huang, R. L., Lai, H. C., Hsu, Y. W., Kuo, P. J., Chen, C. E., Lin, H. Y., Whang-Peng, J., Nieh, S., Fu, E., Liu, L. F. & Hwang, J., 2016, In : Oncotarget. 7, 38, p. 61930-61944 15 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

The ethyl acetate fraction of corn silk exhibits dual antioxidant and anti-glycation activities and protects insulin-secreting cells from glucotoxicity

Chang, C. C., Yuan, W., Roan, H. Y., Chang, J. L., Huang, H. C., Lee, Y. C., Tsay, H. J. & Liu, H. K., Nov 3 2016, In : BMC Complementary and Alternative Medicine. 16, 1, 432.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The Impact of dUTPase on Ribonucleotide Reductase-Induced Genome Instability in Cancer Cells

Chen, C. W., Tsao, N., Huang, L. Y., Yen, Y., Liu, X., Lehman, C., Wang, Y. H., Tseng, M. C., Chen, Y. J., Ho, Y. C., Chen, C. F. & Chang, Z. F., Aug 2 2016, In : Cell Reports. 16, 5, p. 1287-1299 13 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Thrombomodulin influences the survival of patients with non-metastatic colorectal cancer through epithelial-to-mesenchymal transition (EMT)

Chang, Y. J., Cheng, Y. W., Lin, R. K., Huang, C. C., Chen, W. T. L., Ke, T. W. & Wei, P. L., Aug 1 2016, In : PLoS One. 11, 8, e0160550.

Research output: Contribution to journalArticle

6 Citations (Scopus)
11 Citations (Scopus)

TW-01, a piperazinedione-derived compound, inhibits Ras-mediated cell proliferation and angioplasty-induced vascular restenosis

Lin, C. F., Huang, H. L., Peng, C. Y., Lee, Y. C., Wang, H. P., Teng, C. M. & Pan, S. L., Aug 15 2016, In : Toxicology and Applied Pharmacology. 305, p. 194-202 9 p.

Research output: Contribution to journalArticle

Using structural-based protein engineering to modulate the differential inhibition effects of SAUGI on human and HSV uracil DNA glycosylase

Wang, H. C., Ho, C. H., Chou, C. C., Ko, T. P., Huang, M. F., Hsu, K. C. & Wang, A. H. J., May 19 2016, In : Nucleic Acids Research. 44, 9, p. 4440-4449 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2017

1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma

Liu, Y. M., HuangFu, W. C., Huang, H. L., Wu, W. C., Chen, Y. L., Yen, Y., Huang, H. L., Nien, C. Y., Lai, M. J., Pan, S. L. & Liou, J. P., Nov 10 2017, In : European Journal of Medicinal Chemistry. 140, p. 84-91 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity

Lee, H-Y., Lee, J. F., Kumar, S., Wu, Y. W., HuangFu, W-C., Lai, M-J., Li, Y-H., Huang, H. L., Kuo, F. C., Hsiao, C. J., Cheng, C. C., Yang, C. R. & Liou, J-P., Jan 5 2017, In : European Journal of Medicinal Chemistry. 125, p. 1268-1278 11 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors in vitro and in vivo

Mehndiratta, S., Wang, R. S., Huang, H. L., Su, C. J., Hsu, C. M., Wu, Y. W., Pan, S. L. & Liou, J. P., Jul 7 2017, In : European Journal of Medicinal Chemistry. 134, p. 13-23 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

A combination of anti-PD-L1 mAb plus Lm-LLO-E6 vaccine efficiently suppresses tumor growth and metastasis in HPV-infected cancers

Lin, P. L., Cheng, Y. M., Wu, D. W., Huang, Y. J., Lin, H. C., Chen, C. Y. & Lee, H., 2017, (Accepted/In press) In : Cancer Medicine.

Research output: Contribution to journalArticle

10 Citations (Scopus)

ADAM9 enhances CDCP1 by inhibiting miR-1 through EGFR signaling activation in lung cancer metastasis

Chiu, K. L., Lin, Y. S., Kuo, T. T., Lo, C. C., Huang, Y. K., Chang, H. F., Chuang, E. Y., Lin, C. C., Cheng, W. C., Liu, Y. N., Lai, L. C. & Sher, Y. P., 2017, In : Oncotarget. 8, 29, p. 47365-47378 14 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

An increase in BAG-1 by PD-L1 confers resistance to tyrosine kinase inhibitor in non–small cell lung cancer via persistent activation of ERK signalling

Lin, P. L., Wu, T. C., Wu, D. W., Wang, L., Chen, C. Y. & Lee, H., Nov 1 2017, In : European Journal of Cancer. 85, p. 95-105 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells

Chao, M. W., Huang, H. L., HuangFu, W. C., Hsu, K. C., Liu, Y. M., Wu, Y. W., Lin, C. F., Chen, Y. L., Lai, M. J., Lee, H. Y., Liou, J. P., Teng, C. M. & Yang, C. R., 2017, In : Oncotarget. 8, 17, p. 27772-27785 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo

Huangfu, W. C., Chao, M. W., Cheng, C. C., Wei, Y. C., Wu, Y. W., Liou, J. P., Hsiao, G., Lee, Y. C. & Yang, C. R., Feb 9 2017, In : Scientific Reports. 7, 42291.

Research output: Contribution to journalArticle

2 Citations (Scopus)
16 Citations (Scopus)

Crosstalk between integrin αvβ3 and ERα contributes to thyroid hormone-induced proliferation of ovarian cancer cells

Hsieh, M. T., Wang, L. M., Changou, C. A., Chin, Y. T., Yang, Y. C. S. H., Lai, H. Y., Lee, S. Y., Yang, Y. N., Whang-Peng, J., Liu, L. F., Lin, H. Y., Mousa, S. A. & Davis, P. J., 2017, In : Oncotarget. 8, 15, p. 24237-24249 13 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Distinct roles and differential expression levels of Wnt5a mRNA isoforms in colorectal cancer cells

Huang, T. C., Lee, P. T., Wu, M. H., Huang, C. C., Ko, C. Y., Lee, Y. C., Lin, D. Y., Cheng, Y. W. & Lee, K. H., Aug 1 2017, In : PLoS One. 12, 8, e0181034.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Does aspirin use reduce the risk for cancer?

Usman, I., Yang, H. C., Jian, W. S., Yen, Y. & Li, Y. C., Feb 1 2017, In : Journal of Investigative Medicine. 65, 2, p. 391-392 2 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Effects of Adlay Hull and Testa Ethanolic Extracts on the Growth of Uterine Leiomyoma Cells

Hsia, S-M., Lin, K-H., Chiang, W., Wu, C-H., Shieh, T-M., Huang, T-C., Chen, H-Y. & Lin, L-C., 2017, In : 調適醫學. 9, 2, p. 85-96 12 p.

Research output: Contribution to journalArticle

Endothelial-derived extracellular matrix ameliorate the stemness deprivation during ex vivo expansion of mouse bone marrow-derived mesenchymal stem cells

Lee, M. K., Lin, S. P., HuangFu, W. C., Yang, D. S. & Liu, I. H., Aug 1 2017, In : PLoS One. 12, 8, e0184111.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Epidermal growth factor receptor signaling promotes metastatic prostate cancer through microRNA-96-mediated downregulation of the tumor suppressor ETV6

Tsai, Y. C., Chen, W. Y., Siu, M. K., Tsai, H. Y., Yin, J. J., Huang, J. & Liu, Y. N., Jan 1 2017, In : Cancer Letters. 384, p. 1-8 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
13 Citations (Scopus)

Human mitochondrial pyrroline-5-carboxylate reductase 1 promotes invasiveness and impacts survival in breast cancers

Ding, J., Kuo, M. L., Su, L., Xue, L., Luh, F., Zhang, H., Wang, J., Lin, T. G., Zhang, K., Chu, P., Zheng, S., Liu, X. & Yen, Y., May 1 2017, In : Carcinogenesis. 38, 5, p. 519-531 13 p., bgx022.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Identification of neuraminidase inhibitors against dual H274Y/I222R mutant strains

Hsu, K. C., Hung, H. C., Huangfu, W. C., Sung, T. Y., Eight Lin, T., Fang, M. Y., Chen, I. J., Pathak, N., Hsu, J. T. A. & Yang, J. M., Dec 1 2017, In : Scientific Reports. 7, 1, 12336.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Important Roles of Ring Finger Protein 112 in Embryonic Vascular Development and Brain Functions

Tsou, J. H., Yang, Y. C., Pao, P. C., Lin, H. C., Huang, N. K., Lin, S. T., Hsu, K. S., Yeh, C. M., Lee, K. H., Kuo, C. J., Yang, D. M., Lin, J. H., Chang, W. C. & Lee, Y. C., 2017, In : Molecular Neurobiology. p. 1-15 15 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)