Ph.D. Program for Cancer Molecular Biology and Drug Discovery

  • No. 250 Wu-Xing Street

    11031 Taipei

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2016
9 Citations (Scopus)

Integrin β3 and LKB1 are independently involved in the inhibition of proliferation by lovastatin in human intrahepatic cholangiocarcinoma

Yang, S. H., Lin, H. Y., Changou, C. A., Chen, C. H., Liu, Y. R., Wang, J., Jiang, X., Luh, F. & Yen, Y., Jan 1 2016, In : Oncotarget. 7, 1, p. 362-373 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Isoliquiritigenin induces apoptosis and autophagy and inhibits endometrial cancer growth in mice

Wu, C-H., Chen, H. Y., Wang, C-W., Shieh, T. M., Huang, T-C., Lin, L. C., Wang, K. L. & Hsia, S-M., 2016, In : Oncotarget. 7, 45, p. 73432-73447 16 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

KLF4 functions as an activator of the androgen receptor through reciprocal feedback

Siu, M-K., Suau, F., Chen, W-Y., Tsai, Y-C., Tsai, H-Y., Yeh, H-L. & Liu, Y-N., Dec 2016, In : Oncogenesis. 5, 12, p. e282

Research output: Contribution to journalArticle

LTP-1, a novel antimitotic agent and Stat3 inhibitor, inhibits human pancreatic carcinomas in vitro and in vivo

Huang, H. L., Chao, M. W., Chen, C. C., Cheng, C. C., Chen, M. C., Lin, C. F., Liou, J. P., Teng, C. M. & Pan, S. L., Jun 9 2016, In : Scientific Reports. 6, 27794.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Methyl Protodioscin, a Steroidal Saponin, Inhibits Neointima Formation in Vitro and in Vivo

Chung, Y. L., Pan, C. H., Wang, C. C. N., Hsu, K. C., Sheu, M. J., Chen, H. F. & Wu, C. H., Jun 24 2016, In : Journal of Natural Products. 79, 6, p. 1635-1644 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

MiR-30c-2* negative regulated MTA-1 expression involved in metastasis and drug resistance of HPV-infected non-small cell lung cancer

Wu, Y. L., Hsu, N-Y., Lin, F. C. F., Lee, H. & Cheng, Y-W., Dec 1 2016, In : Surgery (United States). 160, 6, p. 1591-1598 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
6 Citations (Scopus)

Novel anthra[1,2-c][1,2,5]thiadiazole-6,11-diones as promising anticancer lead compounds: Biological evaluation, characterization & molecular targets determination

Ali, A. A. A., Lee, Y. R., Chen, T. C., Chen, C. L., Lee, C. C., Shiau, C. Y., Chiang, C. H. & Huang, H. S., Apr 1 2016, In : PLoS One. 11, 4, e0154278.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Novel leptin OB3 peptide-induced signaling and progression in thyroid cancers: Comparison with leptin

Yang, Y. C. S. H., Chin, Y. T., Hsieh, M. T., Lai, H. Y., Ke, C. C., Crawford, D. R., Lee, O. K., Fu, E., Mousa, S. A., Grasso, P., Liu, L-F., Chang, H-Y., Tang, H. Y., Lin, H-Y. & Davis, P. J., May 10 2016, In : Oncotarget. 7, 19, p. 27641-27654 14 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Novel regulators and molecular mechanisms of p53R2 and its disease relevance

Cho, E. C. & Yen, Y., Apr 1 2016, In : Biochimie. 123, p. 81-84 4 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Observation of polarization and thickness dependent third-harmonic generation in multilayer black phosphorus

Wu, H. Y., Yen, Y. & Liu, C. H., Dec 26 2016, In : Applied Physics Letters. 109, 26, 261902.

Research output: Contribution to journalArticle

10 Citations (Scopus)

One-pot green hydrothermal synthesis of fluorescent nitrogen-doped carbon nanodots for in vivo bioimaging

Kuo, T. R., Sung, S. Y., Hsu, C. W., Chang, C. J., Chiu, T. C. & Hu, C. C., Jan 1 2016, In : Analytical and Bioanalytical Chemistry. 408, 1, p. 77-82 6 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

PAK1 confers chemoresistance and poor outcome in non-small cell lung cancer via β-catenin-mediated stemness

Chen, M. J., Wu, D. W., Wang, Y. C., Chen, C. Y. & Lee, H., Oct 7 2016, In : Scientific Reports. 6, 34933.

Research output: Contribution to journalArticle

15 Citations (Scopus)
26 Citations (Scopus)

Paxillin confers resistance to tyrosine kinase inhibitors in EGFR-mutant lung cancers via modulating BIM and Mcl-1 protein stability

Wu, D. W., Chen, C. Y., Chu, C. L. & Lee, H., Feb 4 2016, In : Oncogene. 35, 5, p. 621-630 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Phenyl Benzenesulfonylhydrazides Exhibit Selective Indoleamine 2,3-Dioxygenase Inhibition with Potent in Vivo Pharmacodynamic Activity and Antitumor Efficacy

Lin, S. Y., Yeh, T. K., Kuo, C. C., Song, J. S., Cheng, M. F., Liao, F. Y., Chao, M. W., Huang, H. L., Chen, Y. L., Yang, C. Y., Wu, M. H., Hsieh, C. L., Hsiao, W., Peng, Y. H., Wu, J. S., Lin, L. M., Sun, M., Chao, Y. S., Shih, C., Wu, S. Y. & 3 others, Pan, S. L., Hung, M. S. & Ueng, S. H., Jan 14 2016, In : Journal of Medicinal Chemistry. 59, 1, p. 419-430 12 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Polygonum multiflorum Decreases Airway Allergic Symptoms in a Murine Model of Asthma

Lee, C. C., Lee, Y. L., Wang, C. N., Tsai, H. C., Chiu, C. L., Liu, L. F., Lin, H. Y. & Wu, R., Feb 1 2016, In : American Journal of Chinese Medicine. 44, 1, p. 133-147 15 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Precision Medicine and Pancreatic Cancer

Farrell, J. J., Moughan, J., Wong, J. L., Regine, W. F., Schaefer, P., Benson, A. B., Macdonald, J. S., Liu, X., Yen, Y., Lai, R., Zheng, Z., Bepler, G., Guha, C. & Elsaleh, H., Nov 1 2016, In : Pancreas. 45, 10, p. 1485-1493 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
23 Citations (Scopus)

Primary versus castration-resistant prostate cancer: Modeling through novel murine prostate cancer cell line

Daoud, G., Monzer, A., Bahmad, H., Chamaa, F., Hamdar, L., Mouhieddine, T. H., Shayya, S., Eid, A., Kobeissy, F., Liu, Y. N. & Abou-Kheir, W., May 17 2016, In : Oncotarget. 7, 20, p. 28961-28975 15 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Prognostic and therapeutic value of mitochondrial serine hydroxyl-methyltransferase 2 as a breast cancer biomarker

Zhang, L., Chen, Z., Xue, D., Zhang, Q., Liu, X., Luh, F., Hong, L., Zhang, H., Pan, F., Liu, Y., Chu, P., Zheng, S., Lou, G. & Yen, Y., Nov 1 2016, In : Oncology Reports. 36, 5, p. 2489-2500 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Proton pump inhibitors and risk of periampullary cancers - A nested case-control study

Chien, L-N., Huang, Y. J., Shao, Y-H., Chang, C. J., Chuang, M. T., Chiou, H-Y. & Yen, Y., Mar 15 2016, In : International Journal of Cancer. 138, 6, p. 1401-1409 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Pu-erh Tea Extract Attenuates Nicotine-Induced Foam Cell Formation in Primary Cultured Monocytes: An in Vitro Mechanistic Study

Tu, S. H., Chen, M. Y., Chen, L. C., Mao, Y. T., Ho, C. H., Lee, W. J., Lin, Y-K., Pan, M. H., Lo, C. Y., Chen, C. L., Yen, Y., Whang-Peng, J., Ho, C. T., Wu, C. H. & Ho, Y. S., Apr 27 2016, In : Journal of Agricultural and Food Chemistry. 64, 16, p. 3186-3195 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

PYCR1 and PYCR2 Interact and Collaborate with RRM2B to Protect Cells from Overt Oxidative Stress

Kuo, M. L., Lee, M. B. E., Tang, M., Den Besten, W., Hu, S., Sweredoski, M. J., Hess, S., Chou, C. M., Changou, C. A., Su, M., Jia, W., Su, L. & Yen, Y., Jan 6 2016, In : Scientific Reports. 6, 18846.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Reduction of microRNA-184 by E6 oncoprotein confers cisplatin resistance in lung cancer via increasing Bcl-2

Tung, M. C., Lin, P. L., Cheng, Y. W., Wu, D. W., Yeh, S. D., Chen, C. Y. & Lee, H., May 31 2016, In : Oncotarget. 7, 22, p. 32362-32374 13 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
12 Citations (Scopus)

Research of StemBios cell therapy on dental implants containing nanostructured surfaces: Biomechanical behaviors, microstructural characteristics, and clinical trial

Ou, K. L., Weng, C. C., Wu, C. C., Lin, Y. H., Chiang, H. J., Yang, T. S., Wang, J., Yen, Y., Cheng, H. Y. & Sugiatno, E., Feb 1 2016, In : Implant Dentistry. 25, 1, p. 63-73 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

REST reduction is essential for hypoxia-induced neuroendocrine differentiation of prostate cancer cells by activating autophagy signaling

Lin, T. P., Chang, Y. T., Lee, S. Y., Campbell, M., Wang, T. C., Shen, S. H., Chung, H. J., Chang, Y. H., Chiu, A. W., Pan, C. C., Lin, C. H., Chu, C. Y., Kung, H. J., Cheng, C. Y. & Chang, P. C., May 1 2016, In : Oncotarget. 7, 18, p. 26137-26151 15 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Resveratrol inhibits proliferation of myometrial and leiomyoma cells and decreases extracellular matrix-associated protein expression

Wu, C. H., Shieh, T. M., Wei, L. H., Cheng, T. F., Chen, H. Y., Huang, T. C., Wang, K. L. & Hsia, S. M., May 1 2016, In : Journal of Functional Foods. 23, p. 241-252 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

RINT-1 interacts with MSP58 within nucleoli and plays a role in ribosomal gene transcription

Yang, C. P., Kuo, Y. L., Lee, Y. C., Lee, K. H., Chiang, C. W., Wang, J. M., Hsu, C. C., Chang, W. C. & Lin, D. Y., Sep 16 2016, In : Biochemical and Biophysical Research Communications. 478, 2, p. 873-880 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Selective recognition and stabilization of new ligands targeting the potassium form of the human telomeric G-quadruplex DNA

Lin, Y. H., Chuang, S. M., Wu, P. C., Chen, C. L., Jeyachandran, S., Lo, S. C., Huang, H. S. & Hou, M. H., Aug 11 2016, In : Scientific Reports. 6, 31019.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Signature miRNAs in colorectal cancers were revealed using a bias reduction small RNA deep sequencing protocol

Sun, G., Cheng, Y. W., Lai, L., Huang, T. C., Wang, J., Wu, X., Wang, Y., Huang, Y., Wang, J., Zhang, K., Hu, S., Yang, J. R. & Yen, Y., 2016, In : Oncotarget. 7, 4, p. 3857-3872 16 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Sterol O-acyltransferase 2 contributes to the yolk cholesterol trafficking during zebrafish embryogenesis

Chang, N. Y., Chan, Y. J., Ding, S. T., Lee, Y. H., Huangfu, W. C. & Liu, I. H., Dec 1 2016, In : PLoS One. 11, 12, e0167644.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Systematic discovery of drug action mechanisms by an integrated chemical genomics approach: Identification of functional disparities between azacytidine and decitabine

Hsieh, Y. Y., Huang, T. C., Lo, H. L., Jhan, J. Y., Chen, S. T. & Yang, P. M., May 10 2016, In : Oncotarget. 7, 19, p. 27363-27378 16 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

TC-N19, a novel dual inhibitor of EGFR and cMET, efficiently overcomes EGFR-TKI resistance in non-small-cell lung cancer cells

Wu, D. W., Chen, T. C., Huang, H. S. & Lee, H., Jun 30 2016, In : Cell death & disease. 7, 6, p. e2290

Research output: Contribution to journalArticle

14 Citations (Scopus)

The combination of tetraiodothyroacetic acid and cetuximab inhibits cell proliferation in colorectal cancers with different K-ras status

Lee, Y. S., Chin, Y. T., Yang, Y. C. S. H., Wei, P. L., Wu, H. C., Shih, A., Lu, Y. T., Pedersen, J. Z., Incerpi, S., Liu, L. F., Lin, H. Y. & Davis, P. J., 2016, In : Steroids. p. 63-70

Research output: Contribution to journalArticle

14 Citations (Scopus)

The cytokine-cosmc signaling axis upregulates the tumorassociated carbohydrate antigen Tn

Ho, C. W., Lin, C. Y., Liaw, Y. W., Chiang, H. L., Chin, Y. T., Huang, R. L., Lai, H. C., Hsu, Y. W., Kuo, P. J., Chen, C. E., Lin, H. Y., Whang-Peng, J., Nieh, S., Fu, E., Liu, L. F. & Hwang, J., 2016, In : Oncotarget. 7, 38, p. 61930-61944 15 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

The ethyl acetate fraction of corn silk exhibits dual antioxidant and anti-glycation activities and protects insulin-secreting cells from glucotoxicity

Chang, C. C., Yuan, W., Roan, H. Y., Chang, J. L., Huang, H. C., Lee, Y. C., Tsay, H. J. & Liu, H. K., Nov 3 2016, In : BMC Complementary and Alternative Medicine. 16, 1, 432.

Research output: Contribution to journalArticle

8 Citations (Scopus)

The Impact of dUTPase on Ribonucleotide Reductase-Induced Genome Instability in Cancer Cells

Chen, C. W., Tsao, N., Huang, L. Y., Yen, Y., Liu, X., Lehman, C., Wang, Y. H., Tseng, M. C., Chen, Y. J., Ho, Y. C., Chen, C. F. & Chang, Z. F., Aug 2 2016, In : Cell Reports. 16, 5, p. 1287-1299 13 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Thrombomodulin influences the survival of patients with non-metastatic colorectal cancer through epithelial-to-mesenchymal transition (EMT)

Chang, Y. J., Cheng, Y. W., Lin, R. K., Huang, C. C., Chen, W. T. L., Ke, T. W. & Wei, P. L., Aug 1 2016, In : PLoS One. 11, 8, e0160550.

Research output: Contribution to journalArticle

6 Citations (Scopus)
11 Citations (Scopus)

TW-01, a piperazinedione-derived compound, inhibits Ras-mediated cell proliferation and angioplasty-induced vascular restenosis

Lin, C. F., Huang, H. L., Peng, C. Y., Lee, Y. C., Wang, H. P., Teng, C. M. & Pan, S. L., Aug 15 2016, In : Toxicology and Applied Pharmacology. 305, p. 194-202 9 p.

Research output: Contribution to journalArticle

Using structural-based protein engineering to modulate the differential inhibition effects of SAUGI on human and HSV uracil DNA glycosylase

Wang, H. C., Ho, C. H., Chou, C. C., Ko, T. P., Huang, M. F., Hsu, K. C. & Wang, A. H. J., May 19 2016, In : Nucleic Acids Research. 44, 9, p. 4440-4449 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2015
16 Citations (Scopus)

A KRAS mutation status-stratified randomized phase II trial of gemcitabine and oxaliplatin alone or in combination with cetuximab in advanced biliary tract cancer

Chen, J. S., Hsu, C., Chiang, N. J., Tsai, C. S., Tsou, H. H., Huang, S. F., Bai, L. Y., Chang, I. C., Shiah, H. S., Ho, C. L., Yen, C. J., Lee, K. D., Chiu, C. F., Rau, K. M., Yu, M. S., Yang, Y., Hsieh, R. K., Chang, J. Y., Shan, Y. S., Chao, Y. & 13 others, Chen, L. T., Chin, Y. H., Chung, T. R., Yu, W. L., Lee, M. H., Lin, L. F., Lin, P. C., Wu, Y. L., Wang, H. L., Lu, L. J., Chen, S. Y., Wu, C. C. & Wei, T. C., May 1 2015, In : Annals of Oncology. 26, 5, p. 943-949 7 p., mdv035.

Research output: Contribution to journalArticle

75 Citations (Scopus)

Alpha 7-nicotinic acetylcholine receptor mediates the sensitivity of gastric cancer cells to 5-fluorouracil

Chen, W-Y., Huang, C. Y., Cheng, W. L., Hung, C-S., Huang, M-T., Tai, C-J., Liu, Y-N., Chen, C-L. & Chang, Y-J., Jul 3 2015, (Accepted/In press) In : Tumor Biology. 36, 12, p. 9537-9544

Research output: Contribution to journalArticle

12 Citations (Scopus)

Association of cytoplasmic p27 expression with an unfavorable response to cisplatin-based chemotherapy and poor outcomes in non-small cell lung cancer

Lin, T. C., Tsai, L. H., Chou, M. C., Chen, C. Y. & Lee, H., Oct 20 2015, (Accepted/In press) In : Tumor Biology.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Attenuating HIV Tat/TAR-mediated protein expression by exploring the side chain length of positively charged residues

Wu, C. H., Chen, Y. P., Liu, S. L., Chien, F. C., Mou, C. Y. & Cheng, R. P., 2015, In : Organic and Biomolecular Chemistry. 13, 45, p. 11096-11104 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)