Ph.D. Program for Cancer Molecular Biology and Drug Discovery

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output 1996 2020

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Article
2016
12 Citations (Scopus)

The combination of tetraiodothyroacetic acid and cetuximab inhibits cell proliferation in colorectal cancers with different K-ras status

Lee, Y. S., Chin, Y. T., Yang, Y. C. S. H., Wei, P. L., Wu, H. C., Shih, A., Lu, Y. T., Pedersen, J. Z., Incerpi, S., Liu, L. F., Lin, H. Y. & Davis, P. J., 2016, In : Steroids. p. 63-70

Research output: Contribution to journalArticle

Cell proliferation
Colorectal Neoplasms
Cell Proliferation
HCT116 Cells
Cyclin D1
3 Citations (Scopus)

The cytokine-cosmc signaling axis upregulates the tumorassociated carbohydrate antigen Tn

Ho, C. W., Lin, C. Y., Liaw, Y. W., Chiang, H. L., Chin, Y. T., Huang, R. L., Lai, H. C., Hsu, Y. W., Kuo, P. J., Chen, C. E., Lin, H. Y., Whang-Peng, J., Nieh, S., Fu, E., Liu, L. F. & Hwang, J., 2016, In : Oncotarget. 7, 38, p. 61930-61944 15 p.

Research output: Contribution to journalArticle

Up-Regulation
Carbohydrates
Cytokines
Conditioned Culture Medium
Inflammation
7 Citations (Scopus)

The ethyl acetate fraction of corn silk exhibits dual antioxidant and anti-glycation activities and protects insulin-secreting cells from glucotoxicity

Chang, C. C., Yuan, W., Roan, H. Y., Chang, J. L., Huang, H. C., Lee, Y. C., Tsay, H. J. & Liu, H. K., Nov 3 2016, In : BMC Complementary and Alternative Medicine. 16, 1, 432.

Research output: Contribution to journalArticle

Silk
Insulin-Secreting Cells
Zea mays
Antioxidants
Insulin
8 Citations (Scopus)

The Impact of dUTPase on Ribonucleotide Reductase-Induced Genome Instability in Cancer Cells

Chen, C. W., Tsao, N., Huang, L. Y., Yen, Y., Liu, X., Lehman, C., Wang, Y. H., Tseng, M. C., Chen, Y. J., Ho, Y. C., Chen, C. F. & Chang, Z. F., Aug 2 2016, In : Cell Reports. 16, 5, p. 1287-1299 13 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Genomic Instability
Genes
Cells
Genome
10 Citations (Scopus)

Therapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS

Chang, C-F., Lee, Y-C., Lee, K-H., Lin, C. H., Chen, C-L., Shen, C. K. J. & Huang, C-C., Oct 21 2016, In : Journal of Biomedical Science. 23, 1, 72.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Berberine
Therapeutic Uses
Autophagy
TDP-43 Proteinopathies
Peroxynitrous Acid
Cyclooxygenase 2
Superoxide Dismutase
Skin
HIV
5 Citations (Scopus)

Thrombomodulin influences the survival of patients with non-metastatic colorectal cancer through epithelial-to-mesenchymal transition (EMT)

Chang, Y. J., Cheng, Y. W., Lin, R. K., Huang, C. C., Chen, W. T. L., Ke, T. W. & Wei, P. L., Aug 1 2016, In : PLoS One. 11, 8, e0160550.

Research output: Contribution to journalArticle

Thrombomodulin
Epithelial-Mesenchymal Transition
colorectal neoplasms
Colorectal Neoplasms
Survival
9 Citations (Scopus)
Urinary Bladder Neoplasms
Autophagy
G1 Phase Cell Cycle Checkpoints
cdc Genes
Cyclin E

TW-01, a piperazinedione-derived compound, inhibits Ras-mediated cell proliferation and angioplasty-induced vascular restenosis

Lin, C. F., Huang, H. L., Peng, C. Y., Lee, Y. C., Wang, H. P., Teng, C. M. & Pan, S. L., Aug 15 2016, In : Toxicology and Applied Pharmacology. 305, p. 194-202 9 p.

Research output: Contribution to journalArticle

3,6-bis(5-chloro-2-piperidyl)-2,5-piperazinedione
Cell proliferation
Angioplasty
Blood Vessels
Cell Proliferation
7 Citations (Scopus)

Using structural-based protein engineering to modulate the differential inhibition effects of SAUGI on human and HSV uracil DNA glycosylase

Wang, H. C., Ho, C. H., Chou, C. C., Ko, T. P., Huang, M. F., Hsu, K. C. & Wang, A. H. J., May 19 2016, In : Nucleic Acids Research. 44, 9, p. 4440-4449 10 p.

Research output: Contribution to journalArticle

Uracil-DNA Glycosidase
Protein Engineering
Human Herpesvirus 4
DNA
Proteins
2015
13 Citations (Scopus)
Histone Deacetylase Inhibitors
Tumors
Prostatic Neoplasms
Cells
Lead compounds
67 Citations (Scopus)

A KRAS mutation status-stratified randomized phase II trial of gemcitabine and oxaliplatin alone or in combination with cetuximab in advanced biliary tract cancer

Chen, J. S., Hsu, C., Chiang, N. J., Tsai, C. S., Tsou, H. H., Huang, S. F., Bai, L. Y., Chang, I. C., Shiah, H. S., Ho, C. L., Yen, C. J., Lee, K. D., Chiu, C. F., Rau, K. M., Yu, M. S., Yang, Y., Hsieh, R. K., Chang, J. Y., Shan, Y. S., Chao, Y. & 13 others, Chen, L. T., Chin, Y. H., Chung, T. R., Yu, W. L., Lee, M. H., Lin, L. F., Lin, P. C., Wu, Y. L., Wang, H. L., Lu, L. J., Chen, S. Y., Wu, C. C. & Wei, T. C., May 1 2015, In : Annals of Oncology. 26, 5, p. 943-949 7 p., mdv035.

Research output: Contribution to journalArticle

oxaliplatin
gemcitabine
Biliary Tract Neoplasms
Mutation
Exanthema
9 Citations (Scopus)

Alpha 7-nicotinic acetylcholine receptor mediates the sensitivity of gastric cancer cells to 5-fluorouracil

Chen, W-Y., Huang, C. Y., Cheng, W. L., Hung, C-S., Huang, M-T., Tai, C-J., Liu, Y-N., Chen, C-L. & Chang, Y-J., Jul 3 2015, (Accepted/In press) In : Tumor Biology. 36, 12, p. 9537-9544

Research output: Contribution to journalArticle

Nicotinic Receptors
Fluorouracil
Stomach Neoplasms
In Situ Nick-End Labeling
Cell Cycle
6 Citations (Scopus)

Association of cytoplasmic p27 expression with an unfavorable response to cisplatin-based chemotherapy and poor outcomes in non-small cell lung cancer

Lin, T. C., Tsai, L. H., Chou, M. C., Chen, C. Y. & Lee, H., Oct 20 2015, (Accepted/In press) In : Tumor Biology.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cisplatin
Drug Therapy
Neoplasms
Cell Nucleus Active Transport
3 Citations (Scopus)

Attenuating HIV Tat/TAR-mediated protein expression by exploring the side chain length of positively charged residues

Wu, C. H., Chen, Y. P., Liu, S. L., Chien, F. C., Mou, C. Y. & Cheng, R. P., 2015, In : Organic and Biomolecular Chemistry. 13, 45, p. 11096-11104 9 p.

Research output: Contribution to journalArticle

human immunodeficiency virus
Chain length
peptides
HIV
RNA

Autophagic effect of SAM-competitive EZH2 inhibitors on cancer cells

Liu, T. P. & Yang, P-M., 2015, In : Cancer Cell & Microenvironment. 2, p. e551-e551

Research output: Contribution to journalArticle

S-Adenosylmethionine
Autophagy
Neoplasms
Epigenomics
Enhancer of Zeste Homolog 2 Protein
13 Citations (Scopus)

Bcl-2 stabilization by paxillin confers 5-fluorouracil resistance in colorectal cancer

Wu, D. W., Huang, C. C., Chang, S. W., Chen, T. H. & Lee, H., Apr 1 2015, In : Cell Death and Differentiation. 22, 5, p. 779-789 11 p.

Research output: Contribution to journalArticle

Paxillin
Fluorouracil
Colorectal Neoplasms
Protein Kinases
Protein Stability
29 Citations (Scopus)
Berberine
Epithelial-Mesenchymal Transition
Prostatic Neoplasms
Genes
Neoplasm Metastasis
7 Citations (Scopus)

Chromatophagy: Autophagy goes nuclear and captures broken chromatin during argininestarvation

Kung, H. J., Changou, C. A., Li, C. F. & Ann, D. K., Jan 1 2015, In : Autophagy. 11, 2, p. 419-421 3 p.

Research output: Contribution to journalArticle

Autophagy
Tumor Cell Line
Cell Nucleus
DNA Damage
Chromatin
2 Citations (Scopus)
cancer
statistical significance
system development
Disease
7 Citations (Scopus)

Detection of lysyl oxidase-like 2 (LOXL2), a biomarker of metastasis from breast cancers using human blood samples

Janyasupab, M., Lee, Y. H., Zhang, Y., Liu, C. W., Cai, J., Popa, A., Samia, A. C., Wang, K. W., Xu, J., Hu, C. C., Wendt, M. K., Schiemann, B. J., Thompson, C. L., Yen, Y., Schiemann, W. P. & Liu, C. C., Aug 1 2015, In : Recent Patents on Biomarkers. 5, 2, p. 93-100 8 p.

Research output: Contribution to journalArticle

Protein-Lysine 6-Oxidase
Biomarkers
Blood
Breast Neoplasms
Neoplasm Metastasis
13 Citations (Scopus)

Discovery of 5-(2′,4′-difluorophenyl)-salicylanilides as new inhibitors of receptor activator of NF-κ°B ligand (RANKL)-induced osteoclastogenesis

Lee, C. C., Liu, F. L., Chen, C. L., Chen, T. C., Chang, D. M. & Huang, H. S., May 25 2015, In : European Journal of Medicinal Chemistry. 98, p. 115-126 12 p.

Research output: Contribution to journalArticle

Salicylanilides
Osteoclasts
Osteogenesis
Ligands
Assays
59 Citations (Scopus)

EGF receptor promotes prostate cancer bone metastasis by downregulating miR-1 and activating TWIST1

Chang, Y. S., Chen, W. Y., Yin, J. J., Sheppard-Tillman, H., Huang, J. & Liu, Y. N., Aug 1 2015, In : Cancer Research. 75, 15, p. 3077-3086 10 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Epidermal Growth Factor Receptor
Prostatic Neoplasms
Down-Regulation
Neoplasm Metastasis
10 Citations (Scopus)

eIF4E binding protein 1 expression is associated with clinical survival outcomes in colorectal cancer

Chao, M. W., Wang, L. T., Lai, C. Y., Yang, X. M., Cheng, Y. W., Lee, K. H., Pan, S. L. & Teng, C. M., 2015, In : Oncotarget. 6, 27, p. 24092-24104 13 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Carrier Proteins
Survival
Vascular Endothelial Growth Factor A
YXM110
27 Citations (Scopus)

FHIT loss confers cisplatin resistance in lung cancer via the AKT/NF-κB/Slug-mediated PUMA reduction

Wu, D. W., Lee, M. C., Hsu, N. Y., Wu, T. C., Wu, J. Y., Wang, Y. C., Cheng, Y. W., Chen, C. Y. & Lee, H., May 7 2015, In : Oncogene. 34, 19, p. 2505-2515 11 p.

Research output: Contribution to journalArticle

Gastropoda
Histidine
Cisplatin
Lung Neoplasms
Non-Small Cell Lung Carcinoma
35 Citations (Scopus)

Fluorescence-guided probes of aptamer-targeted gold nanoparticles with computed tomography imaging accesses for in vivo tumor resection

Li, C. H., Kuo, T. R., Su, H. J., Lai, W. Y., Yang, P. C., Chen, J. S., Wang, D. Y., Wu, Y. C. & Chen, C. C., Oct 28 2015, In : Scientific Reports. 5, 15675.

Research output: Contribution to journalArticle

Gold
Nanoparticles
Fluorescence
Tomography
Neoplasms
Mouth Neoplasms
Oncogene Proteins
Lung Neoplasms
Neoplasms
Thiostrepton
10 Citations (Scopus)

Gluconeogenesis, lipogenesis, and HBV replication are commonly regulated by PGC-1α-dependent pathway

Jhuang, H. J., Hsu, W. H., Lin, K. T., Hsu, S. L., Wang, F. S., Chou, C. K., Lee, K. H., Tsou, A. P., Lai, J. M., Yeh, S. F. & Huang, C. Y. F., 2015, In : Oncotarget. 6, 10, p. 7788-7803 16 p.

Research output: Contribution to journalArticle

Lipogenesis
Gluconeogenesis
Virus Replication
Hepatitis B virus
Glucocorticoids
18 Citations (Scopus)

Heteronemin, a spongean sesterterpene, induces cell apoptosis and autophagy in human renal carcinoma cells

Wu, S. Y., Sung, P. J., Chang, Y. L., Pan, S. L. & Teng, C. M., 2015, In : BioMed Research International. 2015, 738241.

Research output: Contribution to journalArticle

Sesterterpenes
Autophagy
Renal Cell Carcinoma
Cells
Apoptosis
80 Citations (Scopus)

High PD-L1 expression correlates with metastasis and poor prognosis in oral squamous cell carcinoma

Lin, Y. M., Sung, W. W., Hsieh, M. J., Tsai, S. C., Lai, H. W., Yang, S. M., Shen, K. H., Chen, M. K., Lee, H., Yeh, K. T. & Chen, C. J., Nov 1 2015, In : PLoS One. 10, 11, e0142656.

Research output: Contribution to journalArticle

squamous cell carcinoma
metastasis
prognosis
Squamous Cell Carcinoma
mouth
15 Citations (Scopus)

KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination

Chen, H. Y., Hu, J. Y., Chen, T. H., Lin, Y. C., Liu, X., Lin, M. Y., Lang, Y. D., Yen, Y. & Chen, R. H., Oct 1 2015, In : Oncogene. 34, 40, p. 5141-5151 11 p.

Research output: Contribution to journalArticle

Death-Associated Protein Kinases
Cullin Proteins
Ubiquitination
Colonic Neoplasms
Neoplasm Metastasis
24 Citations (Scopus)

Landscape of Pin1 in the cell cycle

Lin, C. H., Li, H. Y., Lee, Y. C., Calkins, M. J., Lee, K. H., Yang, C. N. & Lu, P. J., Mar 25 2015, In : Experimental Biology and Medicine. 240, 3, p. 403-408 6 p.

Research output: Contribution to journalArticle

Cell Cycle
Cells
Substrates
Peptidylprolyl Isomerase
Cyclin E
30 Citations (Scopus)

Loss of androgen-regulated MicroRNA 1 activates SRC and promotes prostate cancer bone metastasis

Liu, Y. N., Yin, J., Barrett, B., Sheppard-Tillman, H., Li, D., Casey, O. M., Fang, L., Hynes, P. G., Ameri, A. H. & Kelly, K., 2015, In : Molecular and Cellular Biology. 35, 11, p. 1940-1951 12 p.

Research output: Contribution to journalArticle

Bone Neoplasms
MicroRNAs
Androgens
Prostatic Neoplasms
Neoplasm Metastasis
13 Citations (Scopus)

Lovastatin overcomes gefitinib resistance through TNF-a signaling in human cholangiocarcinomas with different LKB1 statuses in vitro and in vivo

Yang, S. H., Lin, H. Y., Chang, V. H. S., Chen, C. C., Liu, Y. R., Wang, J., Zhang, K., Jiang, X. & Yen, Y., 2015, In : Oncotarget. 6, 27, p. 23857-23873 17 p.

Research output: Contribution to journalArticle

Lovastatin
Cholangiocarcinoma
Heterografts
In Vitro Techniques
gefitinib
18 Citations (Scopus)

Lowered circulating aspartate is a metabolic feature of human breast cancer

Xie, G., Zhou, B., Zhao, A., Qiu, Y., Zhao, X., Garmire, L., Shvetsov, Y. B., Yu, H., Yen, Y. & Jia, W., Jan 1 2015, In : Oncotarget. 6, 32, p. 33369-33381 13 p.

Research output: Contribution to journalArticle

Aspartic Acid
Breast Neoplasms
Neoplasms
Cell Line
Metabolomics
17 Citations (Scopus)

Low thyroid hormone levels improve survival in murine model for ocular melanoma

Fabian, I. D., Rosner, M., Fabian, I., Vishnevskia-Dai, V., Zloto, O., Maman, E. S., Cohen, K., Ellis, M., Lin, H. Y., Hercbergs, A., Davis, P. J. & Ashur-Fabian, O., 2015, In : Oncotarget. 6, 13, p. 11038-11046 9 p.

Research output: Contribution to journalArticle

Thyroid Hormones
Melanoma
Propylthiouracil
Thyroxine
Hyperthyroidism
23 Citations (Scopus)

Mechanisms of dihydrotestosterone action on resveratrolinduced anti-proliferation in breast cancer cells with different ER status

Chin, Y. T., Yang, S. H., Chang, T. C., Changou, C. A., Lai, H. Y., Fu, E., HuangFu, W. C., Davis, P. J., Lin, H. Y. & Liu, L. F., 2015, In : Oncotarget. 6, 34, p. 35866-35879 14 p.

Research output: Contribution to journalArticle

Dihydrotestosterone
Breast Neoplasms
Apoptosis
p53 Genes
Integrins
23 Citations (Scopus)

MicroRNA-184 Deregulated by the MicroRNA-21 Promotes Tumor Malignancy and Poor Outcomes in Non-small Cell Lung Cancer via Targeting CDC25A and c-Myc

Lin, T. C., Lin, P. L., Cheng, Y. W., Wu, T. C., Chou, M. C., Chen, C. Y. & Lee, H., Dec 1 2015, In : Annals of Surgical Oncology. 22, p. 1532-1539 8 p.

Research output: Contribution to journalArticle

MicroRNAs
Non-Small Cell Lung Carcinoma
Neoplasms
Messenger RNA
Survival
64 Citations (Scopus)

MicroRNA-34a regulates WNT/TCF7 signaling and inhibits bone metastasis in Ras-activated prostate cancer

Chen, W. Y., Liu, S. Y., Chang, Y. S., Yin, J. J., Yeh, H. L., Mouhieddine, T. H., Hadadeh, O., Abou-Kheir, W. & Liu, Y. N., 2015, In : Oncotarget. 6, 1, p. 441-457 17 p.

Research output: Contribution to journalArticle

MicroRNAs
Prostatic Neoplasms
Neoplasm Metastasis
Bone and Bones
3' Untranslated Regions
62 Citations (Scopus)

MiR-92a Promotes Cell Metastasis of Colorectal Cancer Through PTEN-Mediated PI3K/AKT Pathway

Ke, T. W., Wei, P. L., Yeh, K. T., Chen, W. T. L. & Cheng, Y. W., Aug 1 2015, In : Annals of Surgical Oncology. 22, 8, p. 2649-2655 7 p.

Research output: Contribution to journalArticle

MicroRNAs
Phosphatidylinositol 3-Kinases
Colorectal Neoplasms
Neoplasm Metastasis
Cadherins
21 Citations (Scopus)

MnSOD overexpression confers cisplatin resistance in lung adenocarcinoma via the NF-κB/Snail/Bcl-2 pathway

Chen, P. M., Cheng, Y. W., Wu, T. C., Chen, C. Y. & Lee, H., 2015, In : Free Radical Biology and Medicine. 79, p. 127-137 11 p.

Research output: Contribution to journalArticle

Cisplatin
Superoxide Dismutase
Tumors
Neoplasms
Curcumin
2 Citations (Scopus)
Acrylamide
Colorectal Neoplasms
Histone Deacetylases
Cadherins
Neoplasms
3 Citations (Scopus)

MT-4 suppresses resistant ovarian cancer growth through targeting tubulin and HSP27

Pai, H. C., Kumar, S., Shen, C. C., Liou, J. P., Pan, S. L. & Che, M. T., Apr 14 2015, In : PLoS One. 10, 4, e0123819.

Research output: Contribution to journalArticle

ovarian neoplasms
Tubulin
tubulin
Ovarian Neoplasms
apoptosis
44 Citations (Scopus)

Mutant p53 confers chemoresistance in non-small cell lung cancer by upregulating Nrf2

Tung, M. C., Lin, P. L., Wang, Y. C., He, T. Y., Lee, M. C., Yeh, S. D., Chen, C. Y. & Lee, H., 2015, In : Oncotarget. 6, 39, p. 41692-41705 14 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cisplatin
Messenger RNA
Up-Regulation
bcl-2 Genes
18 Citations (Scopus)

Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR-mutated lung cancer via nickel-induced microRNA-21 expression

Chiou, Y. H., Liou, S. H., Wong, R. H., Chen, C. Y. & Lee, H., Aug 9 2015, In : Toxicology Letters. 237, 1, p. 46-54 9 p.

Research output: Contribution to journalArticle

Nickel
MicroRNAs
Tumors
Lung Neoplasms
Mutation
5 Citations (Scopus)

NKX2-1-mediated p53 expression modulates lung adenocarcinoma progression via modulating IKKβ/NF-κB activation

Chen, P. M., Wu, T. C., Cheng, Y. W., Chen, C. Y. & Lee, H., 2015, In : Oncotarget. 6, 16, p. 14274-14289 16 p.

Research output: Contribution to journalArticle

Messenger RNA
Neoplasms
Epithelial-Mesenchymal Transition
Survival
Adenocarcinoma of lung
6 Citations (Scopus)

Novel inhibitors of RANKL-induced osteoclastogenesis: Design, synthesis, and biological evaluation of 6-(2,4-difluorophenyl)-3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-diones

Lee, C. C., Liu, F. L., Chen, C. L., Chen, T. C., Liu, F. C., Ahmed Ali, A. A., Chang, D. M. & Huang, H. S., Jul 23 2015, In : Bioorganic and Medicinal Chemistry. 23, 15, p. 4522-4532 11 p.

Research output: Contribution to journalArticle

Oxazines
Osteoclasts
Osteogenesis
Assays
Cathepsin K
7 Citations (Scopus)

Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo

Huang, H-L., Peng, C-Y., Lai, M-J., Chen, C-H., Lee, H. Y., Wang, J-C., Liou, J. P., Pan, S. L. & Teng, C-M., 2015, In : Oncotarget. 6, 7, p. 4976-4991 16 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
B-Cell Lymphoma
Human Activities
Growth
Apoptosis
16 Citations (Scopus)

N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling

Lai, M-J., Lee, H. Y., Chuang, H-Y., Chang, L-H., Tsai, A-C., Chen, M. C., Huang, H-L., Wu, Y-W., Teng, C-M., Pan, S. L., Liu, Y-M., Mehndiratta, S. & Liou, J. P., Aug 27 2015, In : Journal of Medicinal Chemistry. 58, 16, p. 6549-6558 10 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Tubulin
Phosphorylation
Polymerization
Antineoplastic Agents
10 Citations (Scopus)
ovarian neoplasms
Centromere
centromeres
Ovarian Neoplasms
Tumor Biomarkers