Ph.D. Program for Cancer Molecular Biology and Drug Discovery

  • No. 250 Wu-Xing Street

    11031 Taipei

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2016

Chemotherapy for advanced biliary tract carcinoma: A meta-analysis of randomized controlled trials

Chen, L., Chen, C., Yen, Y. & Tam, K. W., Aug 1 2016, In : Medicine (United States). 95, 33, 385.

Research output: Contribution to journalArticle

8 Citations (Scopus)
8 Citations (Scopus)
7 Citations (Scopus)

Corrigendum to "Inactivation of p53 in pterygium influence miR-200a expression resulting in ZEB1/ZEB2 up-regulation and EMT processing" [Exp. Eye Res. 146 (2016) 206-211]

Wu, C. W., Peng, M. L., Yeh, K. T., Tsai, Y. Y., Chiang, C. C. & Cheng, Y. W., 2016, (Accepted/In press) In : Experimental Eye Research.

Research output: Contribution to journalArticle

1 Citation (Scopus)

CRLX101 nanoparticles localize in human tumors and not in adjacent, nonneoplastic tissue after intravenous dosing

Clark, A. J., Wiley, D. T., Zuckerman, J. E., Webster, P., Chao, J., Lin, J., Yen, Y. & Davis, M. E., Apr 5 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 14, p. 3850-3854 5 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Cytoplasmic localization of Nrf2 promotes colorectal cancer with more aggressive tumors via upregulation of PSMD4

Lin, P. L., Chang, J. T., Wu, D. W., Huang, C. C. & Lee, H., Jun 1 2016, In : Free Radical Biology and Medicine. 95, p. 121-132 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

DDX3 enhances oncogenic KRAS-induced tumor invasion in colorectal cancer via the β-catenin/ZEB1 axis

Wu, D. W., Lin, P. L., Cheng, Y. W., Huang, C. C., Wang, L. & Lee, H., Apr 19 2016, In : Oncotarget. 7, 16, p. 22687-22699 13 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

DDX3 promotes tumor invasion in colorectal cancer via the CK1ε/Dvl2 axis

He, T. Y., Wu, D. W., Lin, P. L., Wang, L., Huang, C. C., Chou, M. C. & Lee, H., Feb 19 2016, In : Scientific Reports. 6, 21483.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Design, synthesis and biological evaluation of tetracyclic azafluorenone derivatives with topoisomerase I inhibitory properties as potential anticancer agents

Chen, T. C., Yu, D-S., Chen, S-J., Chen, C-L., Lee, C-C., Hsieh, Y-Y., Chang, L-C., Guh, J-H., Lin, J-J. & Huang, H-S., 2016, In : Arabian Journal of Chemistry.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Design, synthesis and SARs of novel salicylanilides as potent inhibitors of RANKL-induced osteoclastogenesis and bone resorption

Chen, C. L., Lee, C. C., Liu, F. L., Chen, T. C., Ahmed Ali, A. A., Chang, D. M. & Huang, H. S., Jul 19 2016, In : European Journal of Medicinal Chemistry. 117, p. 70-84 15 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Design and synthesis of 1,2,3-triazole-containing N-acyl zanamivir analogs as potent neuraminidase inhibitors

Das, A., Adak, A. K., Ponnapalli, K., Lin, C. H., Hsu, K. C., Yang, J. M., Hsu, T. A. & Lin, C. C., Nov 10 2016, In : European Journal of Medicinal Chemistry. 123, p. 397-406 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Development of 1-Amino-4-(phenylamino)anthraquinone-2-sulfonate Sodium Derivatives as a New Class of Inhibitors of RANKL-Induced Osteoclastogenesis

Lee, C. C., Chen, C. L., Liu, F. L., Chiou, C. Y., Chen, T. C., Wu, C. C., Sun, W. H., Chang, D. M. & Huang, H. S., May 1 2016, In : Archiv der Pharmazie. 349, 5, p. 342-355 14 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations

Tseng, T. S., Chuang, S. M., Hsiao, N. W., Chen, Y. W., Lee, Y. C., Lin, C. C., Huang, C. & Tsai, K. C., Jan 1 2016, In : Molecular BioSystems. 12, 8, p. 2541-2551 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Down-regulation of let-7a-5p predicts lymph node metastasis and prognosis in colorectal cancer: Implications for chemotherapy

Liu, T. P., Huang, C. C., Yeh, K. T., Ke, T. W., Wei, P. L., Yang, J. R. & Cheng, Y. W., Dec 1 2016, In : Surgical Oncology. 25, 4, p. 429-434

Research output: Contribution to journalArticle

10 Citations (Scopus)

Effects of Dang-Gui-Bu-Xue-Tang, an herbal decoction, on iron uptake in iron-deficient anemia

Huang, G. C., Chen, S. Y., Tsai, P. W., Ganzon, J. G., Lee, C. J., Shiah, H. S. & Wang, C. C., Mar 2 2016, In : Drug Design, Development and Therapy. 10, p. 949-957 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Elevated HMGA2 expression is associated with cancer aggressiveness and predicts poor outcome in breast cancer

Wu, J., Zhang, S., Shan, J., Hu, Z., Liu, X., Chen, L., Ren, X., Yao, L., Sheng, H., Li, L., Ann, D., Yen, Y., Wang, J. & Wang, X., Jul 1 2016, In : Cancer Letters. 376, 2, p. 284-292 9 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Environmental exposure and HPV infection may act synergistically to induce lung tumorigenesis in nonsmokers

Cheng, Y. W., Lin, F. C. F., Chen, C. Y. & Hsu, N. Y., Apr 12 2016, In : Oncotarget. 7, 15, p. 19850-19862 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Erlotinib-Conjugated Iron Oxide Nanoparticles as a Smart Cancer-Targeted Theranostic Probe for MRI

Ali, A. A. A., Hsu, F. T., Hsieh, C. L., Shiau, C. Y., Chiang, C. H., Wei, Z. H., Chen, C. Y. & Huang, H. S., Nov 11 2016, In : Scientific Reports. 6, 36650.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Evaluation of the In Vivo Therapeutic Effects of Radix Paeoniae Rubra Ethanol Extract with the Hypoglycemic Activities Measured from Multiple Cell-Based Assays

Chang, C. C., Yuan, W., Lin, Y. L., Liu, R. S., Juan, Y. C., Sun, W. H., Tsay, H. J., Huang, H. C., Lee, Y. C. & Liu, H. K., Jan 1 2016, In : Evidence-based Complementary and Alternative Medicine. 2016, 3262790.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Expression levels of estrogen receptor α mRNA in peripheral blood cells are an independent biomarker for postmenopausal osteoporosis

Chou, C. W., Chiang, T. I., Chang, I. C., Huang, C. H. & Cheng, Y. W., Jun 1 2016, In : BBA Clinical. 5, p. 124-129 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1/Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer

Chen, I. C., Lee, K. H., Hsu, Y. H., Wang, W. R., Chen, C. M. & Cheng, Y. W., 2016, In : Disease Markers. 2016, 8169724.

Research output: Contribution to journalArticle

14 Citations (Scopus)
15 Citations (Scopus)

Glucocorticoids may compromise the effect of gefitinib in non-small cell lung cancer

Wang, H. Y., Chang, Y. L., Cheng, C. C., Chao, M. W., Lin, S. I., Pan, S-L., Hsu, C. C., Liu, T. W., Cheng, H. C., Tseng, C. P., Liu, S. J., Tsai, H. J., Chang, H. Y. & Hsu, J. T. A., 2016, In : Oncotarget. 7, 52, p. 85917-85928 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Glucose-regulated protein 94 mediates cancer progression via AKT and eNOS in hepatocellular carcinoma

Huang, C. Y., Batzorig, U., Cheng, W. L., Huang, M. T., Chen, W. Y., Wei, P. L. & Chang, Y. J., Apr 1 2016, In : Tumor Biology. 37, 4, p. 4295-4304

Research output: Contribution to journalArticle

12 Citations (Scopus)
6 Citations (Scopus)

HIF-1-alpha links mitochondrial perturbation to the dynamic acquisition of breast cancer tumorigenicity

Kuo, C. Y., Cheng, C. T., Hou, P., Lin, Y. P., Ma, H., Chung, Y., Chi, K., Chen, Y., Li, W., Kung, H. J. & Ann, D. K., Jun 7 2016, In : Oncotarget. 7, 23, p. 34052-34069 18 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation

Chang, L. C., Chen, T. C., Chen, S. J., Chen, C. L., Lee, C. C., Wu, S. H., Yen, Y., Huang, H. S. & Lin, J. J., Oct 18 2016, In : Oncotarget. 7, 42, p. 67986-68001 16 p.

Research output: Contribution to journalArticle

Identification of Inhibitors for the DEDDh Family of Exonucleases and a Unique Inhibition Mechanism by Crystal Structure Analysis of CRN-4 Bound with 2-Morpholin-4-ylethanesulfonate (MES)

Huang, K. W., Hsu, K. C., Chu, L. Y., Yang, J. M., Yuan, H. S. & Hsiao, Y. Y., Sep 8 2016, In : Journal of Medicinal Chemistry. 59, 17, p. 8019-8029 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Indole-3-ethylsulfamoylphenylacrylamides with potent anti-proliferative and anti-angiogenic activities

Mehndiratta, S., Pan, S. L., Kumar, S. & Liou, J. P., Jul 1 2016, In : Anti-Cancer Agents in Medicinal Chemistry. 16, 7, p. 907-913 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
9 Citations (Scopus)

Integrin β3 and LKB1 are independently involved in the inhibition of proliferation by lovastatin in human intrahepatic cholangiocarcinoma

Yang, S. H., Lin, H. Y., Changou, C. A., Chen, C. H., Liu, Y. R., Wang, J., Jiang, X., Luh, F. & Yen, Y., Jan 1 2016, In : Oncotarget. 7, 1, p. 362-373 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Isoliquiritigenin induces apoptosis and autophagy and inhibits endometrial cancer growth in mice

Wu, C-H., Chen, H. Y., Wang, C-W., Shieh, T. M., Huang, T-C., Lin, L. C., Wang, K. L. & Hsia, S-M., 2016, In : Oncotarget. 7, 45, p. 73432-73447 16 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

KLF4 functions as an activator of the androgen receptor through reciprocal feedback

Siu, M-K., Suau, F., Chen, W-Y., Tsai, Y-C., Tsai, H-Y., Yeh, H-L. & Liu, Y-N., Dec 2016, In : Oncogenesis. 5, 12, p. e282

Research output: Contribution to journalArticle

LTP-1, a novel antimitotic agent and Stat3 inhibitor, inhibits human pancreatic carcinomas in vitro and in vivo

Huang, H. L., Chao, M. W., Chen, C. C., Cheng, C. C., Chen, M. C., Lin, C. F., Liou, J. P., Teng, C. M. & Pan, S. L., Jun 9 2016, In : Scientific Reports. 6, 27794.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Methyl Protodioscin, a Steroidal Saponin, Inhibits Neointima Formation in Vitro and in Vivo

Chung, Y. L., Pan, C. H., Wang, C. C. N., Hsu, K. C., Sheu, M. J., Chen, H. F. & Wu, C. H., Jun 24 2016, In : Journal of Natural Products. 79, 6, p. 1635-1644 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

MiR-30c-2* negative regulated MTA-1 expression involved in metastasis and drug resistance of HPV-infected non-small cell lung cancer

Wu, Y. L., Hsu, N-Y., Lin, F. C. F., Lee, H. & Cheng, Y-W., Dec 1 2016, In : Surgery (United States). 160, 6, p. 1591-1598 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
5 Citations (Scopus)

Novel anthra[1,2-c][1,2,5]thiadiazole-6,11-diones as promising anticancer lead compounds: Biological evaluation, characterization & molecular targets determination

Ali, A. A. A., Lee, Y. R., Chen, T. C., Chen, C. L., Lee, C. C., Shiau, C. Y., Chiang, C. H. & Huang, H. S., Apr 1 2016, In : PLoS One. 11, 4, e0154278.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Novel leptin OB3 peptide-induced signaling and progression in thyroid cancers: Comparison with leptin

Yang, Y. C. S. H., Chin, Y. T., Hsieh, M. T., Lai, H. Y., Ke, C. C., Crawford, D. R., Lee, O. K., Fu, E., Mousa, S. A., Grasso, P., Liu, L-F., Chang, H-Y., Tang, H. Y., Lin, H-Y. & Davis, P. J., May 10 2016, In : Oncotarget. 7, 19, p. 27641-27654 14 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Novel regulators and molecular mechanisms of p53R2 and its disease relevance

Cho, E. C. & Yen, Y., Apr 1 2016, In : Biochimie. 123, p. 81-84 4 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Observation of polarization and thickness dependent third-harmonic generation in multilayer black phosphorus

Wu, H. Y., Yen, Y. & Liu, C. H., Dec 26 2016, In : Applied Physics Letters. 109, 26, 261902.

Research output: Contribution to journalArticle

10 Citations (Scopus)

One-pot green hydrothermal synthesis of fluorescent nitrogen-doped carbon nanodots for in vivo bioimaging

Kuo, T. R., Sung, S. Y., Hsu, C. W., Chang, C. J., Chiu, T. C. & Hu, C. C., Jan 1 2016, In : Analytical and Bioanalytical Chemistry. 408, 1, p. 77-82 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

PAK1 confers chemoresistance and poor outcome in non-small cell lung cancer via β-catenin-mediated stemness

Chen, M. J., Wu, D. W., Wang, Y. C., Chen, C. Y. & Lee, H., Oct 7 2016, In : Scientific Reports. 6, 34933.

Research output: Contribution to journalArticle

13 Citations (Scopus)
22 Citations (Scopus)

Paxillin confers resistance to tyrosine kinase inhibitors in EGFR-mutant lung cancers via modulating BIM and Mcl-1 protein stability

Wu, D. W., Chen, C. Y., Chu, C. L. & Lee, H., Feb 4 2016, In : Oncogene. 35, 5, p. 621-630 10 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Phenyl Benzenesulfonylhydrazides Exhibit Selective Indoleamine 2,3-Dioxygenase Inhibition with Potent in Vivo Pharmacodynamic Activity and Antitumor Efficacy

Lin, S. Y., Yeh, T. K., Kuo, C. C., Song, J. S., Cheng, M. F., Liao, F. Y., Chao, M. W., Huang, H. L., Chen, Y. L., Yang, C. Y., Wu, M. H., Hsieh, C. L., Hsiao, W., Peng, Y. H., Wu, J. S., Lin, L. M., Sun, M., Chao, Y. S., Shih, C., Wu, S. Y. & 3 others, Pan, S. L., Hung, M. S. & Ueng, S. H., Jan 14 2016, In : Journal of Medicinal Chemistry. 59, 1, p. 419-430 12 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Polygonum multiflorum Decreases Airway Allergic Symptoms in a Murine Model of Asthma

Lee, C. C., Lee, Y. L., Wang, C. N., Tsai, H. C., Chiu, C. L., Liu, L. F., Lin, H. Y. & Wu, R., Feb 1 2016, In : American Journal of Chinese Medicine. 44, 1, p. 133-147 15 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Precision Medicine and Pancreatic Cancer

Farrell, J. J., Moughan, J., Wong, J. L., Regine, W. F., Schaefer, P., Benson, A. B., Macdonald, J. S., Liu, X., Yen, Y., Lai, R., Zheng, Z., Bepler, G., Guha, C. & Elsaleh, H., Nov 1 2016, In : Pancreas. 45, 10, p. 1485-1493 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
22 Citations (Scopus)

Primary versus castration-resistant prostate cancer: Modeling through novel murine prostate cancer cell line

Daoud, G., Monzer, A., Bahmad, H., Chamaa, F., Hamdar, L., Mouhieddine, T. H., Shayya, S., Eid, A., Kobeissy, F., Liu, Y. N. & Abou-Kheir, W., May 17 2016, In : Oncotarget. 7, 20, p. 28961-28975 15 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)