Ph.D. Program for Cancer Molecular Biology and Drug Discovery

  • No. 250 Wu-Xing Street

    11031 Taipei

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2017

REST is a crucial regulator for acquiring EMT-like and stemness phenotypes in hormone-refractory prostate cancer

Chang, Y. T., Lin, T. P., Campbell, M., Pan, C. C., Lee, S. H., Lee, H. C., Yang, M. H., Kung, H. J. & Chang, P. C., Mar 3 2017, In : Scientific Reports. 7, 42795.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Simvastatin inhibits cell proliferation and migration in human anaplastic thyroid cancer

Chen, M. C., Tsai, Y. C., Tseng, J. H., Liou, J. J., Horng, S., Wen, H. C., Fan, Y. C., Zhong, W. B. & Hsu, S. P., Dec 13 2017, In : International Journal of Molecular Sciences. 18, 12, 2690.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Spontaneous and vaccine-induced clearance of Mus musculus papillomavirus 1 infection

Jiang, R. T., Wang, J. W., Peng, S., Huang, T. C., Wang, C., Cannella, F., Chang, Y. N., Viscidi, R. P., Best, S. R. A., Hung, C. F. & Roden, R. B. S., Aug 1 2017, In : Journal of Virology. 91, 15, e00699-17.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Targeted delivery of cisplatin to tumor xenografts via the nanoparticle component of nano-diamino-tetrac

Sudha, T., Bharali, D. J., Yalcin, M., Darwish, N. H. E., Coskun, M. D., Keating, K. A., Lin, H. Y., Davis, P. J. & Mousa, S. A., Feb 1 2017, In : Nanomedicine. 12, 3, p. 195-205 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac

Sudha, T., Bharali, D. J., Yalcin, M., Darwish, N. H. E., Coskun, M. D., Keating, K. A., Lin, H. Y., Davis, P. J. & Mousa, S. A., Feb 15 2017, In : International Journal of Nanomedicine. 12, p. 1305-1315 11 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Targeting insulin-like growth factor-binding protein-3 by microRNA-125b promotes tumor invasion and poor outcomes in non-small-cell lung cancer

Wang, H. H., Wang, Y. C., Wu, D-W., Hung, C. S., Chen, C. Y. & Lee, H., Apr 1 2017, In : Tumor Biology. 39, 4

Research output: Contribution to journalArticle

9 Citations (Scopus)
11 Citations (Scopus)

The apoptotic mechanisms of MT-6, a mitotic arrest inducer, in human ovarian cancer cells

Chen, M. C., Kuo, Y. C., Hsu, C. M., Chen, Y. L., Shen, C. C., Teng, C. M. & Pan, S. L., Apr 7 2017, In : Scientific Reports. 7, 46149.

Research output: Contribution to journalArticle

The Chinese Herbal Mixture Tien-Hsien Liquid Augments the Anticancer Immunity in Tumor Cell-Vaccinated Mice

Yang, P. M., Du, J. L., Wang, G. N. K., Chia, J. S., Hsu, W. B., Pu, P. C., Sun, A., Chiang, C. P. & Wang, W. B., Sep 1 2017, In : Integrative Cancer Therapies. 16, 3, p. 319-328 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The monomeric form of Neisseria DNA mimic protein DMP19 prevents DNA from binding to the histone-like HU protein

Huang, M. F., Lin, S. J., Ko, T. P., Liao, Y. T., Hsu, K. C. & Wang, H. C., Dec 1 2017, In : PLoS One. 12, 12, e0189461.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The simultaneous inhibitory effect of niclosamide on RANKL-induced osteoclast formation and osteoblast differentiation

Liu, F. L., Chen, C. L., Lee, C. C., Wu, C. C., Hsu, T. H., Tsai, C. Y., Huang, H. S. & Chang, D. M., 2017, In : International Journal of Medical Sciences. 14, 9, p. 840-852 13 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The YAP1/SIX2 axis is required for DDX3-mediated tumor aggressiveness and cetuximab resistance in KRAS-wild-type colorectal cancer

Wu, D. W., Lin, P. L., Wang, L., Huang, C. C. & Lee, H., 2017, In : Theranostics. 7, 5, p. 1114-1132 19 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Thrombospondin-2 promotes prostate cancer bone metastasis by the up-regulation of matrix metalloproteinase-2 through down-regulating miR-376c expression

Chen, P. C., Tang, C. H., Lin, L. W., Tsai, C. H., Chu, C. Y., Lin, T. H. & Huang, Y. L., Jan 25 2017, In : Journal of Hematology and Oncology. 10, 1, 33.

Research output: Contribution to journalArticle

23 Citations (Scopus)
8 Citations (Scopus)

Total synthesis and metabolic stability of hispidulin and its d-labelled derivative

Chen, L. C., Hsu, K. C., Chiou, L. C., Tseng, H. J. & Huang, W. J., Nov 1 2017, In : Molecules. 22, 11, 1897.

Research output: Contribution to journalArticle

2 Citations (Scopus)

WISP-3 inhibition of miR-452 promotes VEGF-A expression in chondrosarcoma cells and induces endothelial progenitor cells angiogenesis

Lin, C. Y., Tzeng, H. E., Li, T. M., Chen, H. T., Lee, Y., Yang, Y. C., Wang, S. W., Yang, W. H. & Tang, C. H., Jan 1 2017, In : Oncotarget. 8, 24, p. 39571-39581 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
4 Citations (Scopus)
2016

2,3,5,4′-tetrahydroxystilbene-2-O- β -glucoside isolated from Polygoni Multiflori ameliorates the development of periodontitis

Chin, Y. T., Hsieh, M. T., Lin, C. Y., Kuo, P. J., Yang, Y. C. S. H., Shih, Y. J., Lai, H. Y., Cheng, G. Y., Tang, H. Y., Lee, C. C., Lee, S. Y., Wang, C. C., Lin, H. Y., Fu, E., Whang-Peng, J. & Liu, L. F., 2016, In : Mediators of Inflammation. 2016, 6953459.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Actions of l-thyroxine and Nano-diamino-tetrac (Nanotetrac) on PD-L1 in cancer cells

Lin, H. Y., Chin, Y-T., Nana, A. W., Shih, Y-J., Lai, H-Y., Tang, H-Y., Leinung, M., Mousa, S. A. & Davis, P. J., Jan 28 2016, (Accepted/In press) In : Steroids.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Androgen receptor regulates SRC expression through microRNA-203

Siu, M. K., Chen, W. Y., Tsai, H. Y., Yeh, H. L., Yin, J. J., Liu, S. Y. & Liu, Y-N., May 1 2016, In : Oncotarget. 7, 18, p. 25726-25741 16 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

A new application of parallel synthesis strategy for discovery of amide-linked small molecules as potent chondroprotective agents in TNF-α-stimulated chondrocytes

Lee, C. C., Lo, Y., Ho, L. J., Lai, J. H., Lien, S. B., Lin, L. C., Chen, C. L., Chen, T. C., Liu, F. C. & Huang, H. S., Mar 1 2016, In : PLoS One. 11, 3, e0149317.

Research output: Contribution to journalArticle

5 Citations (Scopus)

A phase I pharmacodynamic study of GTI-2040, an antisense oligonucleotide against ribonuclotide reductase, in acute leukemias: a California Cancer Consortium study

Kirschbaum, M. H., Frankel, P., Synold, T. W., Xie, Z., Yen, Y., Popplewell, L., Chen, R., Aljitawi, O., Tuscano, J. M., Chan, K. K. & Newman, E. M., Oct 2 2016, In : Leukemia and Lymphoma. 57, 10, p. 2307-2314 8 p.

Research output: Contribution to journalArticle

Cellular nuclear export factors TAP and Aly are required for HDAg-L-mediated assembly of hepatitis delta virus

Huang, H. C., Lee, C. P., Liu, H. K., Chang, M. F., Lai, Y. H., Lee, Y. C. & Huang, C., Dec 9 2016, In : Journal of Biological Chemistry. 291, 50, p. 26226-26238 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Chemotherapy for advanced biliary tract carcinoma: A meta-analysis of randomized controlled trials

Chen, L., Chen, C., Yen, Y. & Tam, K. W., Aug 1 2016, In : Medicine (United States). 95, 33, 385.

Research output: Contribution to journalArticle

8 Citations (Scopus)
8 Citations (Scopus)
9 Citations (Scopus)

Corrigendum to "Inactivation of p53 in pterygium influence miR-200a expression resulting in ZEB1/ZEB2 up-regulation and EMT processing" [Exp. Eye Res. 146 (2016) 206-211]

Wu, C. W., Peng, M. L., Yeh, K. T., Tsai, Y. Y., Chiang, C. C. & Cheng, Y. W., 2016, (Accepted/In press) In : Experimental Eye Research.

Research output: Contribution to journalArticle

3 Citations (Scopus)

CRLX101 nanoparticles localize in human tumors and not in adjacent, nonneoplastic tissue after intravenous dosing

Clark, A. J., Wiley, D. T., Zuckerman, J. E., Webster, P., Chao, J., Lin, J., Yen, Y. & Davis, M. E., Apr 5 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 14, p. 3850-3854 5 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Cytoplasmic localization of Nrf2 promotes colorectal cancer with more aggressive tumors via upregulation of PSMD4

Lin, P. L., Chang, J. T., Wu, D. W., Huang, C. C. & Lee, H., Jun 1 2016, In : Free Radical Biology and Medicine. 95, p. 121-132 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

DDX3 enhances oncogenic KRAS-induced tumor invasion in colorectal cancer via the β-catenin/ZEB1 axis

Wu, D. W., Lin, P. L., Cheng, Y. W., Huang, C. C., Wang, L. & Lee, H., Apr 19 2016, In : Oncotarget. 7, 16, p. 22687-22699 13 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

DDX3 promotes tumor invasion in colorectal cancer via the CK1ε/Dvl2 axis

He, T. Y., Wu, D. W., Lin, P. L., Wang, L., Huang, C. C., Chou, M. C. & Lee, H., Feb 19 2016, In : Scientific Reports. 6, 21483.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Design, synthesis and biological evaluation of tetracyclic azafluorenone derivatives with topoisomerase I inhibitory properties as potential anticancer agents

Chen, T. C., Yu, D-S., Chen, S-J., Chen, C-L., Lee, C-C., Hsieh, Y-Y., Chang, L-C., Guh, J-H., Lin, J-J. & Huang, H-S., 2016, In : Arabian Journal of Chemistry.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Design, synthesis and SARs of novel salicylanilides as potent inhibitors of RANKL-induced osteoclastogenesis and bone resorption

Chen, C. L., Lee, C. C., Liu, F. L., Chen, T. C., Ahmed Ali, A. A., Chang, D. M. & Huang, H. S., Jul 19 2016, In : European Journal of Medicinal Chemistry. 117, p. 70-84 15 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Design and synthesis of 1,2,3-triazole-containing N-acyl zanamivir analogs as potent neuraminidase inhibitors

Das, A., Adak, A. K., Ponnapalli, K., Lin, C. H., Hsu, K. C., Yang, J. M., Hsu, T. A. & Lin, C. C., Nov 10 2016, In : European Journal of Medicinal Chemistry. 123, p. 397-406 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Development of 1-Amino-4-(phenylamino)anthraquinone-2-sulfonate Sodium Derivatives as a New Class of Inhibitors of RANKL-Induced Osteoclastogenesis

Lee, C. C., Chen, C. L., Liu, F. L., Chiou, C. Y., Chen, T. C., Wu, C. C., Sun, W. H., Chang, D. M. & Huang, H. S., May 1 2016, In : Archiv der Pharmazie. 349, 5, p. 342-355 14 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations

Tseng, T. S., Chuang, S. M., Hsiao, N. W., Chen, Y. W., Lee, Y. C., Lin, C. C., Huang, C. & Tsai, K. C., Jan 1 2016, In : Molecular BioSystems. 12, 8, p. 2541-2551 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Down-regulation of let-7a-5p predicts lymph node metastasis and prognosis in colorectal cancer: Implications for chemotherapy

Liu, T. P., Huang, C. C., Yeh, K. T., Ke, T. W., Wei, P. L., Yang, J. R. & Cheng, Y. W., Dec 1 2016, In : Surgical Oncology. 25, 4, p. 429-434

Research output: Contribution to journalArticle

13 Citations (Scopus)

Effects of Dang-Gui-Bu-Xue-Tang, an herbal decoction, on iron uptake in iron-deficient anemia

Huang, G. C., Chen, S. Y., Tsai, P. W., Ganzon, J. G., Lee, C. J., Shiah, H. S. & Wang, C. C., Mar 2 2016, In : Drug Design, Development and Therapy. 10, p. 949-957 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Elevated HMGA2 expression is associated with cancer aggressiveness and predicts poor outcome in breast cancer

Wu, J., Zhang, S., Shan, J., Hu, Z., Liu, X., Chen, L., Ren, X., Yao, L., Sheng, H., Li, L., Ann, D., Yen, Y., Wang, J. & Wang, X., Jul 1 2016, In : Cancer Letters. 376, 2, p. 284-292 9 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Environmental exposure and HPV infection may act synergistically to induce lung tumorigenesis in nonsmokers

Cheng, Y. W., Lin, F. C. F., Chen, C. Y. & Hsu, N. Y., Apr 12 2016, In : Oncotarget. 7, 15, p. 19850-19862 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Erlotinib-Conjugated Iron Oxide Nanoparticles as a Smart Cancer-Targeted Theranostic Probe for MRI

Ali, A. A. A., Hsu, F. T., Hsieh, C. L., Shiau, C. Y., Chiang, C. H., Wei, Z. H., Chen, C. Y. & Huang, H. S., Nov 11 2016, In : Scientific Reports. 6, 36650.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Evaluation of the In Vivo Therapeutic Effects of Radix Paeoniae Rubra Ethanol Extract with the Hypoglycemic Activities Measured from Multiple Cell-Based Assays

Chang, C. C., Yuan, W., Lin, Y. L., Liu, R. S., Juan, Y. C., Sun, W. H., Tsay, H. J., Huang, H. C., Lee, Y. C. & Liu, H. K., Jan 1 2016, In : Evidence-based Complementary and Alternative Medicine. 2016, 3262790.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Expression levels of estrogen receptor α mRNA in peripheral blood cells are an independent biomarker for postmenopausal osteoporosis

Chou, C. W., Chiang, T. I., Chang, I. C., Huang, C. H. & Cheng, Y. W., Jun 1 2016, In : BBA Clinical. 5, p. 124-129 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1/Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer

Chen, I. C., Lee, K. H., Hsu, Y. H., Wang, W. R., Chen, C. M. & Cheng, Y. W., 2016, In : Disease Markers. 2016, 8169724.

Research output: Contribution to journalArticle

15 Citations (Scopus)
17 Citations (Scopus)

Glucocorticoids may compromise the effect of gefitinib in non-small cell lung cancer

Wang, H. Y., Chang, Y. L., Cheng, C. C., Chao, M. W., Lin, S. I., Pan, S-L., Hsu, C. C., Liu, T. W., Cheng, H. C., Tseng, C. P., Liu, S. J., Tsai, H. J., Chang, H. Y. & Hsu, J. T. A., 2016, In : Oncotarget. 7, 52, p. 85917-85928 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Glucose-regulated protein 94 mediates cancer progression via AKT and eNOS in hepatocellular carcinoma

Huang, C. Y., Batzorig, U., Cheng, W. L., Huang, M. T., Chen, W. Y., Wei, P. L. & Chang, Y. J., Apr 1 2016, In : Tumor Biology. 37, 4, p. 4295-4304

Research output: Contribution to journalArticle

12 Citations (Scopus)
7 Citations (Scopus)