Ph.D. Program for Cancer Molecular Biology and Drug Discovery

  • No. 250 Wu-Xing Street

    11031 Taipei

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2018

Systematic polypharmacology and drug repurposing via an integrated L1000-based Connectivity Map database mining

Liu, T. P., Hsieh, Y. Y., Chou, C. J. & Yang, P. M., Nov 1 2018, In : Royal Society Open Science. 5, 11, 181321.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Targeting galectin-1 impairs castration-resistant prostate cancer progression and invasion

Shih, T-C., Liu, R., Wu, C-T., Li, X., Xiao, W., Deng, X., Kiss, S., Wang, T., Chen, X-J., Carney, R., Kung, H-J., Duan, Y., Ghosh, P. M. & Lam, K. S., 2018, In : Clinical Cancer Research. 24, 17, p. 4319-4331 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Ten-eleven translocation 1 (TET1) gene is a potential target of miR-21-5p in human colorectal cancer

Cheng, Y. W., Chou, C. J. & Yang, P. M., Mar 1 2018, In : Surgical Oncology. 27, 1, p. 76-81 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Tetrac downregulates β-catenin and HMGA2 to promote the effect of resveratrol in colon cancer

Nana, A. W., Chin, Y. T., Lin, C. Y., Ho, Y., Bennett, J. A., Shih, Y. J., Chen, Y. R., Changou, C. A., Pedersen, J. Z., Incerpi, S., Liu, L. F., Whang-Peng, J., Fu, E., Li, W. S., Mousa, S. A., Lin, H. Y. & Davis, P. J., Mar 1 2018, In : Endocrine-Related Cancer. 25, 3, p. 279-293 15 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells

Tu, H. J., Lin, Y. J., Chao, M. W., Sung, T. Y., Wu, Y. W., Chen, Y. Y., Lin, M. H., Liou, J. P., Pan, S. L. & Yang, C. R., Dec 29 2018, In : Clinical Epigenetics. 10, 1, 162.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes

Wang, Y. C., Chang, K. C., Lin, B. W., Lee, J. C., Lai, C. H., Lin, L. J., Yen, Y., Lin, C. S., Yang, S. J., Lin, P. C., Lee, C. T. & Hung, L. Y., Jun 1 2018, In : Experimental and Molecular Medicine. 50, 6, p. 70 70.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Thyroid Hormone in the Clinic and Breast Cancer

Hercbergs, A., Mousa, S. A., Leinung, M., Lin, H. Y. & Davis, P. J., Feb 13 2018, (Accepted/In press) In : Hormones and Cancer. p. 1-5 5 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Thyroid Hormone Promotes β-Catenin Activation and Cell Proliferation in Colorectal Cancer

Lee, Y. S., Chin, Y. T., Shih, Y. J., Nana, A. W., Chen, Y. R., Wu, H. C., Yang, Y. C. S. H., Lin, H. Y. & Davis, P. J., Jan 29 2018, (Accepted/In press) In : Hormones and Cancer. p. 1-10 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Thyroxine inhibits resveratrol-caused apoptosis by PD-L1 in ovarian cancer cells

Chin, Y. T., Wei, P. L., Ho, Y., Nana, A. W., Changou, C. A., Chen, Y. R., Yang, Y. C. SH., Hsieh, M. T., Hercbergs, A., Davis, P. J., Shih, Y. J. & Lin, H. Y., May 1 2018, In : Endocrine-Related Cancer. 25, 5, p. 533-545 13 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
5 Citations (Scopus)

Tyrosine kinase inhibitors for advanced or metastatic thyroid cancer: a meta-analysis of randomized controlled trials

Liu, J. W., Chen, C., Loh, E. W., Chu, C. C., Wang, M. Y., Ouyang, H. J., Chang, Y. T., Zhuang, W. Z., Chou, C. W., Huang, D. J., Lee, C. H., Yen, Y. & Tam, K. W., 2018, In : Current Medical Research and Opinion. p. 1-9 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Validation of Assaying Carcinoembryonic Antigen in Human Serum by Using Immunomagnetic Reduction

Wei, P. L., Lee, L. T., Tseng, L. M. & Huang, K. W., Dec 1 2018, In : Scientific Reports. 8, 1, 10002.

Research output: Contribution to journalArticle

1 Citation (Scopus)
6 Citations (Scopus)
2017

1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma

Liu, Y. M., HuangFu, W. C., Huang, H. L., Wu, W. C., Chen, Y. L., Yen, Y., Huang, H. L., Nien, C. Y., Lai, M. J., Pan, S. L. & Liou, J. P., Nov 10 2017, In : European Journal of Medicinal Chemistry. 140, p. 84-91 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity

Lee, H-Y., Lee, J. F., Kumar, S., Wu, Y. W., HuangFu, W-C., Lai, M-J., Li, Y-H., Huang, H. L., Kuo, F. C., Hsiao, C. J., Cheng, C. C., Yang, C. R. & Liou, J-P., Jan 5 2017, In : European Journal of Medicinal Chemistry. 125, p. 1268-1278 11 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors in vitro and in vivo

Mehndiratta, S., Wang, R. S., Huang, H. L., Su, C. J., Hsu, C. M., Wu, Y. W., Pan, S. L. & Liou, J. P., Jul 7 2017, In : European Journal of Medicinal Chemistry. 134, p. 13-23 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

A combination of anti-PD-L1 mAb plus Lm-LLO-E6 vaccine efficiently suppresses tumor growth and metastasis in HPV-infected cancers

Lin, P. L., Cheng, Y. M., Wu, D. W., Huang, Y. J., Lin, H. C., Chen, C. Y. & Lee, H., 2017, (Accepted/In press) In : Cancer Medicine.

Research output: Contribution to journalArticle

9 Citations (Scopus)

ADAM9 enhances CDCP1 by inhibiting miR-1 through EGFR signaling activation in lung cancer metastasis

Chiu, K. L., Lin, Y. S., Kuo, T. T., Lo, C. C., Huang, Y. K., Chang, H. F., Chuang, E. Y., Lin, C. C., Cheng, W. C., Liu, Y. N., Lai, L. C. & Sher, Y. P., 2017, In : Oncotarget. 8, 29, p. 47365-47378 14 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

An increase in BAG-1 by PD-L1 confers resistance to tyrosine kinase inhibitor in non–small cell lung cancer via persistent activation of ERK signalling

Lin, P. L., Wu, T. C., Wu, D. W., Wang, L., Chen, C. Y. & Lee, H., Nov 1 2017, In : European Journal of Cancer. 85, p. 95-105 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells

Chao, M. W., Huang, H. L., HuangFu, W. C., Hsu, K. C., Liu, Y. M., Wu, Y. W., Lin, C. F., Chen, Y. L., Lai, M. J., Lee, H. Y., Liou, J. P., Teng, C. M. & Yang, C. R., 2017, In : Oncotarget. 8, 17, p. 27772-27785 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo

Huangfu, W. C., Chao, M. W., Cheng, C. C., Wei, Y. C., Wu, Y. W., Liou, J. P., Hsiao, G., Lee, Y. C. & Yang, C. R., Feb 9 2017, In : Scientific Reports. 7, 42291.

Research output: Contribution to journalArticle

2 Citations (Scopus)
16 Citations (Scopus)

Crosstalk between integrin αvβ3 and ERα contributes to thyroid hormone-induced proliferation of ovarian cancer cells

Hsieh, M. T., Wang, L. M., Changou, C. A., Chin, Y. T., Yang, Y. C. S. H., Lai, H. Y., Lee, S. Y., Yang, Y. N., Whang-Peng, J., Liu, L. F., Lin, H. Y., Mousa, S. A. & Davis, P. J., 2017, In : Oncotarget. 8, 15, p. 24237-24249 13 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Distinct roles and differential expression levels of Wnt5a mRNA isoforms in colorectal cancer cells

Huang, T. C., Lee, P. T., Wu, M. H., Huang, C. C., Ko, C. Y., Lee, Y. C., Lin, D. Y., Cheng, Y. W. & Lee, K. H., Aug 1 2017, In : PLoS One. 12, 8, e0181034.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Does aspirin use reduce the risk for cancer?

Usman, I., Yang, H. C., Jian, W. S., Yen, Y. & Li, Y. C., Feb 1 2017, In : Journal of Investigative Medicine. 65, 2, p. 391-392 2 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Effects of Adlay Hull and Testa Ethanolic Extracts on the Growth of Uterine Leiomyoma Cells

Hsia, S-M., Lin, K-H., Chiang, W., Wu, C-H., Shieh, T-M., Huang, T-C., Chen, H-Y. & Lin, L-C., 2017, In : 調適醫學. 9, 2, p. 85-96 12 p.

Research output: Contribution to journalArticle

Endothelial-derived extracellular matrix ameliorate the stemness deprivation during ex vivo expansion of mouse bone marrow-derived mesenchymal stem cells

Lee, M. K., Lin, S. P., HuangFu, W. C., Yang, D. S. & Liu, I. H., Aug 1 2017, In : PLoS One. 12, 8, e0184111.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Epidermal growth factor receptor signaling promotes metastatic prostate cancer through microRNA-96-mediated downregulation of the tumor suppressor ETV6

Tsai, Y. C., Chen, W. Y., Siu, M. K., Tsai, H. Y., Yin, J. J., Huang, J. & Liu, Y. N., Jan 1 2017, In : Cancer Letters. 384, p. 1-8 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
13 Citations (Scopus)

Human mitochondrial pyrroline-5-carboxylate reductase 1 promotes invasiveness and impacts survival in breast cancers

Ding, J., Kuo, M. L., Su, L., Xue, L., Luh, F., Zhang, H., Wang, J., Lin, T. G., Zhang, K., Chu, P., Zheng, S., Liu, X. & Yen, Y., May 1 2017, In : Carcinogenesis. 38, 5, p. 519-531 13 p., bgx022.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Identification of neuraminidase inhibitors against dual H274Y/I222R mutant strains

Hsu, K. C., Hung, H. C., Huangfu, W. C., Sung, T. Y., Eight Lin, T., Fang, M. Y., Chen, I. J., Pathak, N., Hsu, J. T. A. & Yang, J. M., Dec 1 2017, In : Scientific Reports. 7, 1, 12336.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Important Roles of Ring Finger Protein 112 in Embryonic Vascular Development and Brain Functions

Tsou, J. H., Yang, Y. C., Pao, P. C., Lin, H. C., Huang, N. K., Lin, S. T., Hsu, K. S., Yeh, C. M., Lee, K. H., Kuo, C. J., Yang, D. M., Lin, J. H., Chang, W. C. & Lee, Y. C., 2017, In : Molecular Neurobiology. p. 1-15 15 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Inhibition of the androgen receptor induces a novel tumor promoter, ZBTB46, for prostate cancer metastasis

Chen, W-Y., Tsai, Y-C., Siu, M. K., Yeh, H-L., Chen, C-L., Yin, J. J., Huang, J. & Liu, Y-N., Jul 10 2017, In : Oncogene. p. 6213-6224

Research output: Contribution to journalArticle

12 Citations (Scopus)

In silico and in vitro identification of inhibitory activities of sorafenib on histone deacetylases in hepatocellular carcinoma cells

Liu, T. P., Hong, Y. H. & Yang, P. M., Oct 17 2017, In : Oncotarget. 8, 49, p. 86168-86180 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
7 Citations (Scopus)

Isoliquiritigenin induces autophagy and inhibits ovarian cancer cell growth

Chen, H. Y., Huang, T. C., Shieh, T. M., Wu, C. H., Lin, L. C. & Hsia, S. M., Oct 1 2017, In : International Journal of Molecular Sciences. 18, 10, 2025.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Krüpple-like factor 10 regulates radio-sensitivity of pancreatic cancer via UV radiation resistance-associated gene

Chang, V. H. S., Tsai, Y. C., Tsai, Y. L., Peng, S. L., Chen, S. L., Chang, T. M., Yu, W. C. Y. & Ch'ang, H. J., Mar 1 2017, In : Radiotherapy and Oncology. 122, 3, p. 476-484

Research output: Contribution to journalArticle

4 Citations (Scopus)

Lanatoside C, a cardiac glycoside, acts through protein kinase Cδ to cause apoptosis of human hepatocellular carcinoma cells

Chao, M. W., Chen, T. H., Huang, H. L., Chang, Y. W., HuangFu, W. C., Lee, Y. C., Teng, C. M. & Pan, S. L., Apr 7 2017, In : Scientific Reports. 7, 46134.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Leptin OB3 peptide suppresses leptin-induced signaling and progression in ovarian cancer cells

Chin, Y. T., Wang, L. M., Hsieh, M. T., Shih, Y. J., Nana, A. W., Changou, C. A., Yang, Y. C. S. H., Chiu, H. C., Fu, E., Davis, P. J., Tang, H. Y. & Lin, H. Y., Jul 27 2017, In : Journal of Biomedical Science. 24, 1, 51.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression

Shih, J. W., Chiang, W. F., Wu, A. T. H., Wu, M. H., Wang, L. Y., Yu, Y. L., Hung, Y. W., Wang, W. C., Chu, C. Y., Hung, C. L., Changou, C. A., Yen, Y. & Kung, H. J., Jun 22 2017, In : Nature Communications. 8, 15874.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Loss of SPDEF and gain of TGFBI activity after androgen deprivation therapy promote EMT and bone metastasis of prostate cancer

Chen, W. Y., Tsai, Y. C., Yeh, H. L., Suau, F., Jiang, K. C., Shao, A. N., Huang, J. & Liu, Y. N., Aug 15 2017, In : Science Signaling. 10, 492, eaam6826.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Mechanism and clinical properties of stembios cell therapy: Induction of early osseointegration in novel dental implants

Weng, C. C., Ou, K. L., Wu, C. Y., Huang, Y. H., Wang, J., Yen, Y., Cheng, H. Y. & Lin, Y. H., 2017, In : International Journal of Oral and Maxillofacial Implants. 32, 1, p. e47-e54

Research output: Contribution to journalArticle

Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach

Hsu, K. C., Liu, C. Y., Lin, T. E., Hsieh, J. H., Sung, T. Y., Tseng, H. J., Yang, J. M. & Huang, W. J., Dec 1 2017, In : Scientific Reports. 7, 1, 3228.

Research output: Contribution to journalArticle

19 Citations (Scopus)
13 Citations (Scopus)

Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways

Huang, Y. J., Yang, C. K., Wei, P. L., Huynh, T. T., Whang-Peng, J., Meng, T. C., Hsiao, M., Tzeng, Y. M., Wu, A. T. & Yen, Y., Feb 28 2017, In : Journal of hematology & oncology. 10, 1, p. 60 1 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Overexpression of miR-194 Reverses HMGA2-driven Signatures in Colorectal Cancer

Chang, H. Y., Ye, S. P., Pan, S. L., Kuo, T. T., Liu, B. C., Chen, Y. L. & Huang, T. C., 2017, In : Theranostics. 7, 16, p. 3889-3900 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Overexpression of uridine-cytidine kinase 2 correlates with breast cancer progression and poor prognosis

Shen, G., He, P., Mao, Y., Li, P., Luh, F., Ding, G., Liu, X. & Yen, Y., Jun 1 2017, In : Journal of Breast Cancer. 20, 2, p. 132-141 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Pilot trial of CRLX101 in patients with advanced, chemotherapyrefractory gastroesophageal cancer

Chao, J., Lin, J., Frankel, P., Clark, A. J., Wiley, D. T., Garmey, E., Fakih, M., Lim, D., Chung, V., Luevanos, E., Eliasof, S., Davis, M. E. & Yen, Y., Dec 1 2017, In : Journal of Gastrointestinal Oncology. 8, 6, p. 962-969 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

PRMT1 expression is elevated in head and neck cancer and inhibition of protein arginine methylation by adenosine dialdehyde or PRMT1 knockdown downregulates proliferation and migration of oral cancer cells

Chuang, C. Y., Chang, C. P., Lee, Y. J., Lin, W. L., Chang, W. W., Wu, J. S., Cheng, Y. W., Lee, H. & Li, C., Aug 1 2017, In : Oncology Reports. 38, 2, p. 1115-1123 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Prostate cancer mortality-to-incidence ratios are associated with cancer care disparities in 35 countries

Chen, S. L., Wang, S. C., Ho, C. J., Kao, Y. L., Hsieh, T. Y., Chen, W. J., Chen, C. J., Wu, P. R., Ko, J. L., Lee, H. & Sung, W. W., Jan 4 2017, In : Scientific Reports. 7, 40003.

Research output: Contribution to journalArticle

33 Citations (Scopus)