Ph.D. Program for Cancer Molecular Biology and Drug Discovery

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output 1996 2020

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Article
2017
13 Citations (Scopus)

Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach

Hsu, K. C., Liu, C. Y., Lin, T. E., Hsieh, J. H., Sung, T. Y., Tseng, H. J., Yang, J. M. & Huang, W. J., Dec 1 2017, In : Scientific Reports. 7, 1, 3228.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Histone Deacetylases
Computer Simulation
Protein Isoforms
Enzymes
7 Citations (Scopus)
Neoadjuvant Therapy
Learning Curve
Robotics
Rectal Neoplasms
Laparoscopy
18 Citations (Scopus)

Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways

Huang, Y. J., Yang, C. K., Wei, P. L., Huynh, T. T., Whang-Peng, J., Meng, T. C., Hsiao, M., Tzeng, Y. M., Wu, A. T. & Yen, Y., Feb 28 2017, In : Journal of hematology & oncology. 10, 1, p. 60 1 p.

Research output: Contribution to journalArticle

Colon
Carcinogenesis
Colonic Neoplasms
Macrophages
Neoplasms
11 Citations (Scopus)

Overexpression of miR-194 Reverses HMGA2-driven Signatures in Colorectal Cancer

Chang, H. Y., Ye, S. P., Pan, S. L., Kuo, T. T., Liu, B. C., Chen, Y. L. & Huang, T. C., 2017, In : Theranostics. 7, 16, p. 3889-3900 12 p.

Research output: Contribution to journalArticle

AT-Hook Motifs
Colorectal Neoplasms
Neoplasms
Epithelial-Mesenchymal Transition
MicroRNAs
10 Citations (Scopus)

Overexpression of uridine-cytidine kinase 2 correlates with breast cancer progression and poor prognosis

Shen, G., He, P., Mao, Y., Li, P., Luh, F., Ding, G., Liu, X. & Yen, Y., Jun 1 2017, In : Journal of Breast Cancer. 20, 2, p. 132-141 10 p.

Research output: Contribution to journalArticle

Uridine Kinase
Breast Neoplasms
Gene Expression
Genes
Neoplasms
4 Citations (Scopus)

Pilot trial of CRLX101 in patients with advanced, chemotherapyrefractory gastroesophageal cancer

Chao, J., Lin, J., Frankel, P., Clark, A. J., Wiley, D. T., Garmey, E., Fakih, M., Lim, D., Chung, V., Luevanos, E., Eliasof, S., Davis, M. E. & Yen, Y., Dec 1 2017, In : Journal of Gastrointestinal Oncology. 8, 6, p. 962-969 8 p.

Research output: Contribution to journalArticle

Neoplasms
irinotecan
Investigational Drugs
Drug Therapy
Camptothecin
8 Citations (Scopus)

PRMT1 expression is elevated in head and neck cancer and inhibition of protein arginine methylation by adenosine dialdehyde or PRMT1 knockdown downregulates proliferation and migration of oral cancer cells

Chuang, C. Y., Chang, C. P., Lee, Y. J., Lin, W. L., Chang, W. W., Wu, J. S., Cheng, Y. W., Lee, H. & Li, C., Aug 1 2017, In : Oncology Reports. 38, 2, p. 1115-1123 9 p.

Research output: Contribution to journalArticle

Mouth Neoplasms
Head and Neck Neoplasms
Methylation
Arginine
Down-Regulation
24 Citations (Scopus)

Prostate cancer mortality-to-incidence ratios are associated with cancer care disparities in 35 countries

Chen, S. L., Wang, S. C., Ho, C. J., Kao, Y. L., Hsieh, T. Y., Chen, W. J., Chen, C. J., Wu, P. R., Ko, J. L., Lee, H. & Sung, W. W., Jan 4 2017, In : Scientific Reports. 7, 40003.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Mortality
Incidence
Neoplasms
Health Expenditures
12 Citations (Scopus)

REST is a crucial regulator for acquiring EMT-like and stemness phenotypes in hormone-refractory prostate cancer

Chang, Y. T., Lin, T. P., Campbell, M., Pan, C. C., Lee, S. H., Lee, H. C., Yang, M. H., Kung, H. J. & Chang, P. C., Mar 3 2017, In : Scientific Reports. 7, 42795.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Prostatic Neoplasms
Hormones
Phenotype
Castration
6 Citations (Scopus)

Simvastatin inhibits cell proliferation and migration in human anaplastic thyroid cancer

Chen, M. C., Tsai, Y. C., Tseng, J. H., Liou, J. J., Horng, S., Wen, H. C., Fan, Y. C., Zhong, W. B. & Hsu, S. P., Dec 13 2017, In : International Journal of Molecular Sciences. 18, 12, 2690.

Research output: Contribution to journalArticle

Simvastatin
Cell proliferation
Cell Movement
cancer
Cell Proliferation
10 Citations (Scopus)

Spontaneous and vaccine-induced clearance of Mus musculus papillomavirus 1 infection

Jiang, R. T., Wang, J. W., Peng, S., Huang, T. C., Wang, C., Cannella, F., Chang, Y. N., Viscidi, R. P., Best, S. R. A., Hung, C. F. & Roden, R. B. S., Aug 1 2017, In : Journal of Virology. 91, 15, e00699-17.

Research output: Contribution to journalArticle

Papillomavirus Infections
Papillomaviridae
Mus musculus
papilloma
Papilloma
16 Citations (Scopus)

Targeted delivery of cisplatin to tumor xenografts via the nanoparticle component of nano-diamino-tetrac

Sudha, T., Bharali, D. J., Yalcin, M., Darwish, N. H. E., Coskun, M. D., Keating, K. A., Lin, H. Y., Davis, P. J. & Mousa, S. A., Feb 1 2017, In : Nanomedicine. 12, 3, p. 195-205 11 p.

Research output: Contribution to journalArticle

Heterografts
tumor
Nanoparticles
Cisplatin
Tumors
12 Citations (Scopus)

Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac

Sudha, T., Bharali, D. J., Yalcin, M., Darwish, N. H. E., Coskun, M. D., Keating, K. A., Lin, H. Y., Davis, P. J. & Mousa, S. A., Feb 15 2017, In : International Journal of Nanomedicine. 12, p. 1305-1315 11 p.

Research output: Contribution to journalArticle

Paclitaxel
Heterografts
Nanoparticles
Doxorubicin
Drug delivery
6 Citations (Scopus)

Targeting insulin-like growth factor-binding protein-3 by microRNA-125b promotes tumor invasion and poor outcomes in non-small-cell lung cancer

Wang, H. H., Wang, Y. C., Wu, D-W., Hung, C. S., Chen, C. Y. & Lee, H., Apr 1 2017, In : Tumor Biology. 39, 4

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Protein 3
MicroRNAs
Non-Small Cell Lung Carcinoma
Phosphatidylinositol 3-Kinases
Neoplasms
8 Citations (Scopus)
T Cell Transcription Factor 1
Androgen Receptors
MicroRNAs
Androgens
Prostatic Neoplasms

The apoptotic mechanisms of MT-6, a mitotic arrest inducer, in human ovarian cancer cells

Chen, M. C., Kuo, Y. C., Hsu, C. M., Chen, Y. L., Shen, C. C., Teng, C. M. & Pan, S. L., Apr 7 2017, In : Scientific Reports. 7, 46149.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Apoptosis
Mitochondrial Membrane Potential
G2 Phase
G1 Phase

The Chinese Herbal Mixture Tien-Hsien Liquid Augments the Anticancer Immunity in Tumor Cell-Vaccinated Mice

Yang, P. M., Du, J. L., Wang, G. N. K., Chia, J. S., Hsu, W. B., Pu, P. C., Sun, A., Chiang, C. P. & Wang, W. B., Sep 1 2017, In : Integrative Cancer Therapies. 16, 3, p. 319-328 10 p.

Research output: Contribution to journalArticle

Immunity
Neoplasms
Natural Killer Cells
Cytotoxic T-Lymphocytes
Colonic Neoplasms
9 Citations (Scopus)
Glycyrrhiza
licorice
doxorubicin
autophagy
Autophagy
4 Citations (Scopus)

The monomeric form of Neisseria DNA mimic protein DMP19 prevents DNA from binding to the histone-like HU protein

Huang, M. F., Lin, S. J., Ko, T. P., Liao, Y. T., Hsu, K. C. & Wang, H. C., Dec 1 2017, In : PLoS One. 12, 12, e0189461.

Research output: Contribution to journalArticle

Neisseria
histones
Histones
DNA
Dimers
5 Citations (Scopus)

The simultaneous inhibitory effect of niclosamide on RANKL-induced osteoclast formation and osteoblast differentiation

Liu, F. L., Chen, C. L., Lee, C. C., Wu, C. C., Hsu, T. H., Tsai, C. Y., Huang, H. S. & Chang, D. M., 2017, In : International Journal of Medical Sciences. 14, 9, p. 840-852 13 p.

Research output: Contribution to journalArticle

Niclosamide
Osteoclasts
Osteoblasts
Osteogenesis
Macrophage Colony-Stimulating Factor
14 Citations (Scopus)

The YAP1/SIX2 axis is required for DDX3-mediated tumor aggressiveness and cetuximab resistance in KRAS-wild-type colorectal cancer

Wu, D. W., Lin, P. L., Wang, L., Huang, C. C. & Lee, H., 2017, In : Theranostics. 7, 5, p. 1114-1132 19 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Neoplasms
Animal Models
Agar
Regression Analysis
18 Citations (Scopus)

Thrombospondin-2 promotes prostate cancer bone metastasis by the up-regulation of matrix metalloproteinase-2 through down-regulating miR-376c expression

Chen, P. C., Tang, C. H., Lin, L. W., Tsai, C. H., Chu, C. Y., Lin, T. H. & Huang, Y. L., Jan 25 2017, In : Journal of Hematology and Oncology. 10, 1, 33.

Research output: Contribution to journalArticle

Bone Neoplasms
Matrix Metalloproteinase 2
MicroRNAs
Prostatic Neoplasms
Up-Regulation
3 Citations (Scopus)
Hemorrhoidectomy
Diltiazem
Ointments
Meta-Analysis
Randomized Controlled Trials
1 Citation (Scopus)

Total synthesis and metabolic stability of hispidulin and its d-labelled derivative

Chen, L. C., Hsu, K. C., Chiou, L. C., Tseng, H. J. & Huang, W. J., Nov 1 2017, In : Molecules. 22, 11, 1897.

Research output: Contribution to journalArticle

Derivatives
central nervous system
synthesis
liver
flavone
11 Citations (Scopus)

WISP-3 inhibition of miR-452 promotes VEGF-A expression in chondrosarcoma cells and induces endothelial progenitor cells angiogenesis

Lin, C. Y., Tzeng, H. E., Li, T. M., Chen, H. T., Lee, Y., Yang, Y. C., Wang, S. W., Yang, W. H. & Tang, C. H., Jan 1 2017, In : Oncotarget. 8, 24, p. 39571-39581 11 p.

Research output: Contribution to journalArticle

Chondrosarcoma
Vascular Endothelial Growth Factor A
Osteosarcoma
Endothelial Progenitor Cells
human WISP3 protein
4 Citations (Scopus)
Glioblastoma
Glioma
Cell Cycle
Growth
Survival Rate
2016
12 Citations (Scopus)

2,3,5,4′-tetrahydroxystilbene-2-O- β -glucoside isolated from Polygoni Multiflori ameliorates the development of periodontitis

Chin, Y. T., Hsieh, M. T., Lin, C. Y., Kuo, P. J., Yang, Y. C. S. H., Shih, Y. J., Lai, H. Y., Cheng, G. Y., Tang, H. Y., Lee, C. C., Lee, S. Y., Wang, C. C., Lin, H. Y., Fu, E., Whang-Peng, J. & Liu, L. F., 2016, In : Mediators of Inflammation. 2016, 6953459.

Research output: Contribution to journalArticle

Porphyromonas gingivalis
Periodontitis
Ligation
Lipopolysaccharides
AMP-Activated Protein Kinases
30 Citations (Scopus)

Actions of l-thyroxine and Nano-diamino-tetrac (Nanotetrac) on PD-L1 in cancer cells

Lin, H. Y., Chin, Y-T., Nana, A. W., Shih, Y-J., Lai, H-Y., Tang, H-Y., Leinung, M., Mousa, S. A. & Davis, P. J., Jan 28 2016, (Accepted/In press) In : Steroids.

Research output: Contribution to journalArticle

Thyroxine
Cells
Gene expression
Neoplasms
Proteins
6 Citations (Scopus)

Androgen receptor regulates SRC expression through microRNA-203

Siu, M. K., Chen, W. Y., Tsai, H. Y., Yeh, H. L., Yin, J. J., Liu, S. Y. & Liu, Y-N., May 1 2016, In : Oncotarget. 7, 18, p. 25726-25741 16 p.

Research output: Contribution to journalArticle

Androgen Receptors
MicroRNAs
Prostatic Neoplasms
RNA Stability
3' Untranslated Regions
4 Citations (Scopus)

A new application of parallel synthesis strategy for discovery of amide-linked small molecules as potent chondroprotective agents in TNF-α-stimulated chondrocytes

Lee, C. C., Lo, Y., Ho, L. J., Lai, J. H., Lien, S. B., Lin, L. C., Chen, C. L., Chen, T. C., Liu, F. C. & Huang, H. S., Mar 1 2016, In : PLoS One. 11, 3, e0149317.

Research output: Contribution to journalArticle

chondrocytes
Nitric Oxide Synthase Type II
Chondrocytes
amides
Amides
4 Citations (Scopus)

Cellular nuclear export factors TAP and Aly are required for HDAg-L-mediated assembly of hepatitis delta virus

Huang, H. C., Lee, C. P., Liu, H. K., Chang, M. F., Lai, Y. H., Lee, Y. C. & Huang, C., Dec 9 2016, In : Journal of Biological Chemistry. 291, 50, p. 26226-26238 13 p.

Research output: Contribution to journalArticle

Hepatitis delta Antigens
Hepatitis Delta Virus
Cell Nucleus Active Transport
Viruses
Virion
8 Citations (Scopus)

Chemotherapy for advanced biliary tract carcinoma: A meta-analysis of randomized controlled trials

Chen, L., Chen, C., Yen, Y. & Tam, K. W., Aug 1 2016, In : Medicine (United States). 95, 33, 385.

Research output: Contribution to journalArticle

Biliary Tract
Disease-Free Survival
Meta-Analysis
Biliary Tract Neoplasms
Epidermal Growth Factor Receptor
7 Citations (Scopus)
gemcitabine
Pancreatic Neoplasms
Nausea
Vomiting
Fluorouracil
7 Citations (Scopus)
Autoantibodies
Rheumatoid Arthritis
Biomarkers
Concanavalin A
Peptides
1 Citation (Scopus)

Corrigendum to "Inactivation of p53 in pterygium influence miR-200a expression resulting in ZEB1/ZEB2 up-regulation and EMT processing" [Exp. Eye Res. 146 (2016) 206-211]

Wu, C. W., Peng, M. L., Yeh, K. T., Tsai, Y. Y., Chiang, C. C. & Cheng, Y. W., 2016, (Accepted/In press) In : Experimental Eye Research.

Research output: Contribution to journalArticle

Pterygium
Emotions
Up-Regulation
Western Blotting
Cell Line
78 Citations (Scopus)

CRLX101 nanoparticles localize in human tumors and not in adjacent, nonneoplastic tissue after intravenous dosing

Clark, A. J., Wiley, D. T., Zuckerman, J. E., Webster, P., Chao, J., Lin, J., Yen, Y. & Davis, M. E., Apr 5 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 14, p. 3850-3854 5 p.

Research output: Contribution to journalArticle

Nanoparticles
Camptothecin
Neoplasms
Carbonic Anhydrase I
IT-101
13 Citations (Scopus)

Cytoplasmic localization of Nrf2 promotes colorectal cancer with more aggressive tumors via upregulation of PSMD4

Lin, P. L., Chang, J. T., Wu, D. W., Huang, C. C. & Lee, H., Jun 1 2016, In : Free Radical Biology and Medicine. 95, p. 121-132 12 p.

Research output: Contribution to journalArticle

Tumors
Colorectal Neoplasms
Up-Regulation
Catenins
Neoplasms
22 Citations (Scopus)

DDX3 enhances oncogenic KRAS-induced tumor invasion in colorectal cancer via the β-catenin/ZEB1 axis

Wu, D. W., Lin, P. L., Cheng, Y. W., Huang, C. C., Wang, L. & Lee, H., Apr 19 2016, In : Oncotarget. 7, 16, p. 22687-22699 13 p.

Research output: Contribution to journalArticle

Catenins
Colorectal Neoplasms
Neoplasms
Heterografts
Lung
15 Citations (Scopus)

DDX3 promotes tumor invasion in colorectal cancer via the CK1ε/Dvl2 axis

He, T. Y., Wu, D. W., Lin, P. L., Wang, L., Huang, C. C., Chou, M. C. & Lee, H., Feb 19 2016, In : Scientific Reports. 6, 21483.

Research output: Contribution to journalArticle

Catenins
Colorectal Neoplasms
Neoplasms
Survival
Heterografts
3 Citations (Scopus)

Design, synthesis and biological evaluation of tetracyclic azafluorenone derivatives with topoisomerase I inhibitory properties as potential anticancer agents

Chen, T. C., Yu, D-S., Chen, S-J., Chen, C-L., Lee, C-C., Hsieh, Y-Y., Chang, L-C., Guh, J-H., Lin, J-J. & Huang, H-S., 2016, In : Arabian Journal of Chemistry.

Research output: Contribution to journalArticle

Type I DNA Topoisomerase
Antineoplastic Agents
Cells
Derivatives
Assays
7 Citations (Scopus)

Design, synthesis and SARs of novel salicylanilides as potent inhibitors of RANKL-induced osteoclastogenesis and bone resorption

Chen, C. L., Lee, C. C., Liu, F. L., Chen, T. C., Ahmed Ali, A. A., Chang, D. M. & Huang, H. S., Jul 19 2016, In : European Journal of Medicinal Chemistry. 117, p. 70-84 15 p.

Research output: Contribution to journalArticle

Salicylanilides
Osteoclasts
Bone Resorption
Osteogenesis
Bone
15 Citations (Scopus)

Design and synthesis of 1,2,3-triazole-containing N-acyl zanamivir analogs as potent neuraminidase inhibitors

Das, A., Adak, A. K., Ponnapalli, K., Lin, C. H., Hsu, K. C., Yang, J. M., Hsu, T. A. & Lin, C. C., Nov 10 2016, In : European Journal of Medicinal Chemistry. 123, p. 397-406 10 p.

Research output: Contribution to journalArticle

Zanamivir
Triazoles
Neuraminidase
Inhibitory Concentration 50
Orthomyxoviridae
2 Citations (Scopus)

Development of 1-Amino-4-(phenylamino)anthraquinone-2-sulfonate Sodium Derivatives as a New Class of Inhibitors of RANKL-Induced Osteoclastogenesis

Lee, C. C., Chen, C. L., Liu, F. L., Chiou, C. Y., Chen, T. C., Wu, C. C., Sun, W. H., Chang, D. M. & Huang, H. S., May 1 2016, In : Archiv der Pharmazie. 349, 5, p. 342-355 14 p.

Research output: Contribution to journalArticle

Osteoclasts
Osteogenesis
Sodium
Bone Resorption
Sodium Compounds
1 Citation (Scopus)

Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations

Tseng, T. S., Chuang, S. M., Hsiao, N. W., Chen, Y. W., Lee, Y. C., Lin, C. C., Huang, C. & Tsai, K. C., Jan 1 2016, In : Molecular BioSystems. 12, 8, p. 2541-2551 11 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2 Inhibitors
Anti-Inflammatory Agents
Molecular Docking Simulation
Non-Steroidal Anti-Inflammatory Agents
Prostaglandin-Endoperoxide Synthases
9 Citations (Scopus)

Down-regulation of let-7a-5p predicts lymph node metastasis and prognosis in colorectal cancer: Implications for chemotherapy

Liu, T. P., Huang, C. C., Yeh, K. T., Ke, T. W., Wei, P. L., Yang, J. R. & Cheng, Y. W., Dec 1 2016, In : Surgical Oncology. 25, 4, p. 429-434

Research output: Contribution to journalArticle

Colorectal Neoplasms
Down-Regulation
Lymph Nodes
Neoplasm Metastasis
Drug Therapy
6 Citations (Scopus)

Effects of Dang-Gui-Bu-Xue-Tang, an herbal decoction, on iron uptake in iron-deficient anemia

Huang, G. C., Chen, S. Y., Tsai, P. W., Ganzon, J. G., Lee, C. J., Shiah, H. S. & Wang, C. C., Mar 2 2016, In : Drug Design, Development and Therapy. 10, p. 949-957 9 p.

Research output: Contribution to journalArticle

ferrous sulfate
Anemia
Iron
Hemoglobins
Caco-2 Cells
34 Citations (Scopus)

Elevated HMGA2 expression is associated with cancer aggressiveness and predicts poor outcome in breast cancer

Wu, J., Zhang, S., Shan, J., Hu, Z., Liu, X., Chen, L., Ren, X., Yao, L., Sheng, H., Li, L., Ann, D., Yen, Y., Wang, J. & Wang, X., Jul 1 2016, In : Cancer Letters. 376, 2, p. 284-292 9 p.

Research output: Contribution to journalArticle

AT-Hook Motifs
Breast Neoplasms
Neoplasms
Biological Phenomena
Transcriptome
2 Citations (Scopus)

Environmental exposure and HPV infection may act synergistically to induce lung tumorigenesis in nonsmokers

Cheng, Y. W., Lin, F. C. F., Chen, C. Y. & Hsu, N. Y., Apr 12 2016, In : Oncotarget. 7, 15, p. 19850-19862 13 p.

Research output: Contribution to journalArticle

Papillomavirus Infections
Environmental Exposure
Carcinogenesis
Lung
Benzo(a)pyrene
17 Citations (Scopus)

Erlotinib-Conjugated Iron Oxide Nanoparticles as a Smart Cancer-Targeted Theranostic Probe for MRI

Ali, A. A. A., Hsu, F. T., Hsieh, C. L., Shiau, C. Y., Chiang, C. H., Wei, Z. H., Chen, C. Y. & Huang, H. S., Nov 11 2016, In : Scientific Reports. 6, 36650.

Research output: Contribution to journalArticle

Nanoparticles
Neoplasms
Transmission Electron Microscopy
Heterografts
Nude Mice