Ph.D. Program for Cancer Molecular Biology and Drug Discovery

  • No. 250 Wu-Xing Street

    11031 Taipei

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2018

Correlation between CCL4 gene polymorphisms and clinical aspects of breast cancer

Hu, G. N., Tzeng, H. E., Chen, P. C., Wang, C. Q., Zhao, Y. M., Wang, Y., Su, C. M. & Tang, C. H., Jul 30 2018, In : International Journal of Medical Sciences. 15, 11, p. 1179-1186 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Cytotoxic protobassic acid saponins from the kernels of Palaquium formosanum

Chen, H. Y., Liu, J. F., Tsai, S. F., Lin, Y. L. & Lee, S. S., Apr 2018, In : Journal of Food and Drug Analysis. 26, 2, p. 557-564 8 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Design of diarylheptanoid derivatives as dual inhibitors against class IIa histone deacetylase and β-amyloid aggregation

Chen, L. C., Tseng, H. J., Liu, C. Y., Huang, Y. Y., Yen, C. C., Weng, J. R., Lu, Y. L., Hou, W. C., Lin, T. E., Pan, I. H., Huang, K. K., Huang, W. J. & Hsu, K. C., Jul 3 2018, In : Frontiers in Pharmacology. 9, JUL, 708.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Differences in silencing of mismatched targets by sliced versus diced siRNAs

Sun, G., Wang, J., Huang, Y., Yuan, C. W. Y., Zhang, K., Hu, S., Chen, L., Lin, R. J., Yen, Y. & Riggs, A. D., Jan 1 2018, In : Nucleic Acids Research. 46, 13, p. 6806-6822 17 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Dioscin overcome TKI resistance in EGFR-mutated lung adenocarcinoma cells via down-regulation of tyrosine phosphatase SHP2 expression

Wang, Y. C., Wu, D. W., Wu, T. C., Wang, L., Chen, C. Y. & Lee, H., Jan 11 2018, In : International Journal of Biological Sciences. 14, 1, p. 47-56 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Discovery of aliphatic-chain hydroxamates containing indole derivatives with potent class I histone deacetylase inhibitory activities

Chao, S. W., Chen, L. C., Yu, C. C., Liu, C. Y., Lin, T. E., Guh, J. H., Wang, C. Y., Chen, C. Y., Hsu, K. C. & Huang, W. J., Jan 1 2018, In : European Journal of Medicinal Chemistry. 143, p. 792-805 14 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2 Citations (Scopus)

Distributed and side-pumped fiber laser using a laser diode bar stack

Lee, Y. W., Huangfu, W. C., Li, Y. Y., Wu, I. C., Huang, S. L., Peter Liaw, S. K. & Dubinskii, M., Jan 1 2018, In : IEEE Access. 6, p. 70456-70462 7 p., 8533341.

Research output: Contribution to journalArticle

Dual inhibition of PIK3C3 and FGFR as a new therapeutic approach to treat bladder cancer

Chen, C. H., Changou, C. A., Hsieh, T. H., Lee, Y. C., Chu, C. Y., Hsu, K. C., Wang, H. C., Lin, Y. C., Lo, Y. N., Liu, Y. R., Liou, J. P. & Yen, Y., Mar 1 2018, In : Clinical Cancer Research. 24, 5, p. 1176-1189 14 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Effective Sirolimus Treatment for Refractory Spindle Cell Haemangioma

Ho, C. B., Hsieh, K., Chen, W. Y., Lin, Y. T., Chiou, J. F., Lee, H. L. & Shiah, H. S., May 11 2018, In : British Journal of Dermatology.

Research output: Contribution to journalArticle

Enhancement by Nano-Diamino-Tetrac of Antiproliferative Action of Gefitinib on Colorectal Cancer Cells: Mediation by EGFR Sialylation and PI3K Activation

Chang, T. C., Chin, Y. T., Nana, A. W., Wang, S. H., Liao, Y. M., Chen, Y. R., Shih, Y. J., Changou, C. A., Yang, Y. C. S., Wang, K., Whang-Peng, J., Wang, L. S., Stain, S. C., Shih, A., Lin, H. Y., Wu, C. H. & Davis, P. J., Dec 1 2018, In : Hormones and Cancer. 9, 6, p. 420-432 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Fucoidan Inhibits the Proliferation of Leiomyoma Cells and Decreases Extracellular Matrix-Associated Protein Expression

Chen, H. Y., Huang, T. C., Lin, L. C., Shieh, T. M., Wu, C. H., Wang, K. L., Hong, Y. H. & Hsia, S. M., Oct 1 2018, In : Cellular Physiology and Biochemistry. 49, 5, p. 1970-1986 17 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Generation and characterization of avian-derived anti-human CD19 single chain fragment antibodies

Tsai, K. C., Chiang, C. W., Lo, Y. N., Chang, F. L., Lin, T. Y., Chang, C. Y., Chen, W. C. & Lee, Y. C., Jan 1 2018, (Accepted/In press) In : Animal Biotechnology. 30, 4, p. 293-301 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Global DNA methylation analysis reveals miR-214-3p contributes to cisplatin resistance in pediatric intracranial nongerminomatous malignant germ cell tumors

Hsieh, T. H., Liu, Y. R., Chang, T. Y., Liang, M. L., Chen, H. H., Wang, H. W., Yen, Y. & Wong, T-T., Mar 27 2018, In : Neuro-Oncology. 20, 4, p. 519-530 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Hepatitis B virus X protein represses LKB1 expression to promote tumor progression and poor postoperative outcome in hepatocellular carcinoma

Wu, C. C., Wu, D. W., Lin, Y. Y., Lin, P. L. & Lee, H., Jan 1 2018, (Accepted/In press) In : Surgery (United States).

Research output: Contribution to journalArticle

4 Citations (Scopus)

Heteronemin induces anti-Proliferation in cholangiocarcinoma cells via inhibiting TGF-β pathway

Lin, H. Y., Tey, S. L., Ho, Y., Chin, Y. T., Wang, K., Whang-Peng, J., Shih, Y. J., Chen, Y. R., Yang, Y. N., Chen, Y. C., Liu, Y. C., Tang, H. Y. & Yang, Y. C. SH., Dec 6 2018, In : Marine Drugs. 16, 12, 489.

Research output: Contribution to journalArticle

4 Citations (Scopus)

HMGB1 genetic polymorphisms are biomarkers for the development and progression of breast cancer

Huang, B. F., Tzeng, H. E., Chen, P. C., Wang, C. Q., Su, C. M., Wang, Y., Hu, G. N., Zhao, Y. M., Wang, Q. & Tang, C. H., Mar 12 2018, In : International Journal of Medical Sciences. 15, 6, p. 580-586 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Identification and preclinical evaluation of the small molecule, NSC745887, for treating glioblastomas via suppressing DcR3- associated signaling pathways

Fann, L. Y., Chen, Y., Chu, D. C., Weng, S. J., Chu, H. C., Wu, A. T. H., Lee, J. F., Ali, A. A. A., Chen, T. C., Huang, H. S. & Ma, K. H., Jan 1 2018, In : Oncotarget. 9, 15, p. 11922-11937 16 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
1 Citation (Scopus)

Influences of core morphology on electrocapacitive performance of NiCo2O4-based core/shell electrodes

Lin, L-Y., Lin, H-Y., Hong, W-L. & Lin, L-Y., 2018, In : Thin Solid Films. 667, p. 69-75 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Inhibitory effect of Anoectochilus formosanus extract on hyperglycemia-related PD-L1 expression and cancer proliferation

Ho, Y., Chen, Y. F., Wang, L. H., Hsu, K. Y., Chin, Y. T., Yang, Y. C. S. H., Wang, S. H., Chen, Y. R., Shih, Y. J., Liu, L. F., Wang, K., Whang-Peng, J., Tang, H. Y., Lin, H. Y., Liu, H. L. & Lin, S. J., Aug 2 2018, In : Frontiers in Pharmacology. 9, AUG, p. 807 807.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Interaction of S17 antibody with the functional binding region of the hepatitis B virus pre-S2 epitope

Chang, C. Y., Chang, F. L., Chiang, C. W., Lo, Y. N., Lin, T. Y., Chen, W. C., Tsai, K. C. & Lee, Y. C., Sep 1 2018, In : Viral Immunology. 31, 7, p. 492-499 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Intralymphatic Spread is a Rare Finding Associated with Poor Prognosis in Diffuse Large B-Cell Lymphoma with Extranodal Involvements

Cheng, C. L., Su, Y. C., Chao, T. Y., Lin, C. W., Chou, S. C., Yao, M., Kuo, S. H. & Yu, S. C., Jan 1 2018, In : American Journal of Surgical Pathology. 42, 5, p. 616-624 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

In tumor cells, thyroid hormone analogues non-immunologically regulate PD-L1 and PD-1 accumulation that is anti-apoptotic

Lin, H. Y., Chin, Y. T., Shih, Y. J., Chen, Y. R., Leinung, M., Keating, K. A., Mousa, S. A. & Davis, P. J., Sep 1 2018, In : Oncotarget. 9, 75, p. 34033-34037 5 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

In vitro SUMOylation assay to study SUMO E3 ligase activity

Yang, W. S., Campbell, M., Kung, H. J. & Chang, P. C., Jan 29 2018, In : Journal of Visualized Experiments. 2018, 131, e56629.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Isosteviol Derivative Inhibits Osteoclast Differentiation and Ameliorates Ovariectomy-Induced Osteoporosis

Tzeng, H. E., Huang, P. H., Tsai, C. H., Tsay, G. J., Lee, Y. J., Huang, T. J., Lin, T. H., Chiu, Y. M. & Wu, Y. Y., Dec 1 2018, In : Scientific Reports. 8, 1, 11190.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Machine learning–based radiomics for molecular subtyping of gliomas

Lu, C-F., Hsu, F-T., Hsieh, KL-C., Kao, Y-CJ., Cheng, S-J., Hsu, JB-K., Tsai, P-H., Chen, R-J., Huang, C-C., Yen, Y. & Chen, C-Y., Sep 15 2018, In : Clinical Cancer Research. 24, 18, p. 4429-4436 8 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Manzamine a exerts anticancer activity against human colorectal cancer cells

Lin, L. C., Kuo, T. T., Chang, H. Y., Liu, W. S., Hsia, S. M. & Huang, T. C., Jul 29 2018, In : Marine Drugs. 16, 8, 252.

Research output: Contribution to journalArticle

8 Citations (Scopus)

MicroRNA-19a and microRNA-19b promote the malignancy of clear cell renal cell carcinoma through targeting the tumor suppressor RhoB

Niu, S., Ma, X., Zhang, Y., Liu, Y. N., Chen, X., Gong, H., Yao, Y., Liu, K. & Zhang, X., Feb 1 2018, In : PLoS One. 13, 2, e0192790.

Research output: Contribution to journalArticle

14 Citations (Scopus)

MicroRNA-630 may confer favorable cisplatin-based chemotherapy and clinical outcomes in non-small cell lung cancer by targeting Bcl-2

Chen, M. J., Wu, D. W., Wang, G. C., Wang, Y. C., Chen, C. Y. & Lee, H., Jan 1 2018, In : Oncotarget. 9, 17, p. 13758-13767 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

miR-211 regulates the expression of RRM2 in tumoral metastasis and recurrence in colorectal cancer patients with a k-ras gene mutation

Chang, C. C., Lin, C. C., Wang, C. H., Huang, C. C., Ke, T. W., Wei, P. L., Yeh, K. T., Hsu, K. C., Hsu, N. Y. & Cheng, Y. W., May 1 2018, In : Oncology Letters. 15, 5, p. 8107-8117 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Nano-Diamino-Tetrac (NDAT) Enhances Resveratrol-Induced Antiproliferation by Action on the RRM2 Pathway in Colorectal Cancers

Nana, A. W., Wu, S. Y., Yang, Y. C. S., Chin, Y. T., Cheng, T. M., Ho, Y., Li, W. S., Liao, Y. M., Chen, Y. R., Shih, Y. J., Liu, Y. R., Pedersen, J., Incerpi, S., Hercbergs, A., Liu, L. F., Whang-Peng, J., Davis, P. J. & Lin, H. Y., Oct 1 2018, In : Hormones and Cancer. 9, 5, p. 349-360 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Nano-diamino-tetrac (NDAT) inhibits PD-L1 expression which is essential for proliferation in oral cancer cells

Lin, S. J., Chin, Y. T., Ho, Y., Chou, S. Y., Sh Yang, Y. C., Nana, A. W., Su, K. W., Lim, Y. T., Wang, K., Lee, SY. Y., Shih, Y. J., Chen, Y. R., Whang-Peng, J., Davis, P. J., Lin, H. Y. & Fu, E., Oct 1 2018, In : Food and Chemical Toxicology. 120, p. 1-11 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Novel technique for repairing posterior medial meniscus root tears using porcine knees and biomechanical study

Wu, J. L., Lee, C. H., Yang, C. T., Chang, C. M., Li, G., Cheng, C. K., Chen, C. H., Huang, H. S. & Lai, Y. S., Feb 2018, In : PLoS ONE. 13, 2, e0192027.

Research output: Contribution to journalArticle

5 Citations (Scopus)

PD-L1 confers resistance to EGFR mutation-independent tyrosine kinase inhibitors in non-small cell lung cancer via upregulation of YAP1 expression

Tung, J. N., Lin, P. L., Wang, Y. C., Wu, D. W., Chen, C. Y. & Lee, H., Jan 1 2018, In : Oncotarget. 9, 4, p. 4637-4646 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Phase IB trial of ixabepilone and vorinostat in metastatic breast cancer

Luu, T., Kim, K. P., Blanchard, S., Anyang, B., Hurria, A., Yang, L., Beumer, J. H., Somlo, G. & Yen, Y., Jan 1 2018, In : Breast Cancer Research and Treatment. 167, 2, p. 469-478 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2 Citations (Scopus)

Prediction of type 2 diabetes remission after metabolic surgery: A comparison of the individualized metabolic surgery score and the ABCD score

Chen, J. C., Hsu, N. Y., Lee, W. J., Chen, S. C., Ser, K. H. & Lee, Y. C., Jan 1 2018, (Accepted/In press) In : Surgery for Obesity and Related Diseases.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Protective Effect of Melatonin against Oxidative Stress-Induced Apoptosis and Enhanced Autophagy in Human Retinal Pigment Epithelium Cells

Chang, C. C., Huang, T. Y., Chen, H. Y., Huang, T. C., Lin, L. C., Chang, Y. J. & Hsia, S. M., Jan 1 2018, In : Oxidative Medicine and Cellular Longevity. 2018, 9015765.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Radix Paeoniae Rubra stimulates osteoclast differentiation by activation of the NF-ΚB and mitogen-activated protein kinase pathways

Tzeng, H. E., Tsai, C. H., Ho, T. Y., Hsieh, C. T., Chou, S. C., Lee, Y. J., Tsay, G. J., Huang, P. H. & Wu, Y. Y., Apr 23 2018, In : BMC Complementary and Alternative Medicine. 18, 1, 132.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Resveratrol induces sumoylated COX-2-dependent anti-proliferation in human prostate cancer LNCaP cells

Cheng, T. M., Chin, Y. T., Ho, Y., Chen, Y. R., Yang, Y. N., Yang, Y. C., Shih, Y. J., Lin, T. I., Lin, H. Y. & Davis, P. J., Feb 1 2018, In : Food and Chemical Toxicology. 112, p. 67-75 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Resveratrol inhibits human leiomyoma cell proliferation via crosstalk between integrin αvβ3 and IGF-1R

Ho, Y., SH Yang, Y. C., Chin, Y. T., Chou, S. Y., Chen, Y. R., Shih, Y. J., Whang-Peng, J., Changou, C. A., Liu, H. L., Lin, S. J., Tang, H. Y., Lin, H. Y. & Davis, P. J., Oct 1 2018, In : Food and Chemical Toxicology. 120, p. 346-355 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Ribonucleotide reductase subunit M2B deficiency leads to mitochondrial permeability transition pore opening and is associated with aggressive clinicopathologic manifestations of breast cancer

Xue, L., Liu, X., Wang, Q., Liu, C. Q., Chen, Y., Jia, W., Hsie, R., Chen, Y., Luh, F., Zheng, S. & Yen, Y., Jan 1 2018, In : American Journal of Translational Research. 10, 11, p. 3635-3649 15 p., AJTR0084684.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Risk analysis of malignant potential of oral verrucous hyperplasia: A follow-up study of 269 patients and copy number variation analysis

Wu, M. H., Luo, J. D., Wang, W. C., Chang, T. H., Hwang, W. L., Lee, K. H., Liu, S. Y., Yang, J. W., Chiou, C. T., Chang, C. H. & Chiang, W. F., Jan 1 2018, (Accepted/In press) In : Head and Neck.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Risk of fracture in transfusion-naïve thalassemia population: A nationwide population-based retrospective cohort study

Chen, Y. G., Lu, C. S., Lin, T. Y., Lin, C. L., Tzeng, H. E. & Tsai, C. H., Jan 1 2018, In : Bone. 106, p. 121-125 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Significance of cyclin D1 overexpression in progression and radio-resistance of pediatric ependymomas

Liang, M. L., Hsieh, T. H., Liu, Y. R., Chen, Y. W., Lee, Y. Y., Chang, F. C., Lin, S. C., Huang, M. C., Ho, D. M. T., Wong, T-T., Yen, Y. & Yang, M. H., Jan 1 2018, In : Oncotarget. 9, 2, p. 2527-2542 16 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Sphere-Formation Assay: Three-dimensional in vitro culturing of prostate cancer stem/Progenitor sphere-forming cells

Bahmad, H. F., Cheaito, K., Chalhoub, R. M., Hadadeh, O., Monzer, A., Ballout, F., El-Hajj, A., Mukherji, D., Liu, Y. N., Daoud, G. & Abou-Kheir, W., Aug 28 2018, In : Frontiers in Oncology. 8, AUG, 347.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Systematic polypharmacology and drug repurposing via an integrated L1000-based Connectivity Map database mining

Liu, T. P., Hsieh, Y. Y., Chou, C. J. & Yang, P. M., Nov 1 2018, In : Royal Society Open Science. 5, 11, 181321.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Targeting galectin-1 impairs castration-resistant prostate cancer progression and invasion

Shih, T-C., Liu, R., Wu, C-T., Li, X., Xiao, W., Deng, X., Kiss, S., Wang, T., Chen, X-J., Carney, R., Kung, H-J., Duan, Y., Ghosh, P. M. & Lam, K. S., 2018, In : Clinical Cancer Research. 24, 17, p. 4319-4331 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Ten-eleven translocation 1 (TET1) gene is a potential target of miR-21-5p in human colorectal cancer

Cheng, Y. W., Chou, C. J. & Yang, P. M., Mar 1 2018, In : Surgical Oncology. 27, 1, p. 76-81 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)