Ph.D. Program for Cancer Molecular Biology and Drug Discovery

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    11031 Taipei

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2019

Identification of two independent SUMO-interacting motifs in Fas-associated factor 1 (FAF1): Implications for mineralocorticoid receptor (MR)-mediated transcriptional regulation

Wang, C. H., Hung, P. W., Chiang, C. W., Lombès, M., Chen, C. H., Lee, K. H., Lo, Y. C., Wu, M. H., Chang, W. C. & Lin, D. Y., Aug 1 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 8, p. 1282-1297 16 p.

Research output: Contribution to journalArticle

Immune effector monocyte–neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer

Hagerling, C., Gonzalez, H., Salari, K., Wang, C. Y., Lin, C., Robles, I., van Gogh, M., Dejmek, A., Jirström, K. & Werb, Z., Oct 22 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 43, p. 21704-21714 11 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
Open Access
1 Citation (Scopus)

In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer Cells

Chen, J. C., Hsieh, Y. Y., Lo, H. L., Li, A., Chou, C. J. & Yang, P. M., Sep 9 2019, In : Biomolecules. 9, 9

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC

Wang, H. J., Pochampalli, M., Wang, L. Y., Zou, J. X., Li, P. S., Hsu, S. C., Wang, B. J., Huang, S. H., Yang, P., Yang, J. C., Chu, C. Y., Hsieh, C. L., Sung, S. Y., Li, C. F., Tepper, C. G., Ann, D. K., Gao, A. C., Evans, C. P., Izumiya, Y., Chuu, C. P. & 3 others, Wang, W. C., Chen, H. W. & Kung, H. J., Jan 3 2019, In : Oncogene. 38, 1, p. 17-32

Research output: Contribution to journalArticle

12 Citations (Scopus)

Leptin-derived peptides block leptin-induced proliferation by reducing expression of pro-inflammatory genes in hepatocellular carcinoma cells

Ho, Y., Wang, S. H., Chen, Y. R., Li, Z. L., Chin, Y. T., Yang, Y. C. S. H., Wu, Y. H., Su, K. W., Chu, H. R., Chiu, H. C., Crawford, D. R., Shih, Y. J., Grasso, P., Tang, H. Y., Lin, H. Y., Davis, P. J., Whang-Peng, J. & Wang, K., Nov 1 2019, In : Food and Chemical Toxicology. 133, p. 110808 110808.

Research output: Contribution to journalArticle

Leukemia Inhibitory Factor Promotes Castration-resistant Prostate Cancer and Neuroendocrine Differentiation by Activated ZBTB46

Liu, Y-N., Niu, S., Chen, W-Y., Zhang, Q., Tao, Y., Chen, W-H., Jiang, K-C., Chen, X., Shi, H., Liu, A., Li, J., Li, Y., Lee, Y-C., Zhang, X. & Huang, J., Apr 8 2019, In : Clinical cancer research : an official journal of the American Association for Cancer Research.

Research output: Contribution to journalArticle

3 Citations (Scopus)

LncRNA NORAD is repressed by the YAP pathway and suppresses lung and breast cancer metastasis by sequestering S100P

Tan, B. S., Yang, M. C., Singh, S., Chou, Y. C., Chen, H. Y., Wang, M. Y., Wang, Y. C. & Chen, R. H., Jan 1 2019, In : Oncogene.

Research output: Contribution to journalArticle

12 Citations (Scopus)

miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2

Chen, H. Y., Lang, Y. D., Lin, H. N., Liu, Y. R., Liao, C. C., Nana, A. W., Yen, Y. & Chen, R. H., Dec 1 2019, In : Scientific Reports. 9, 1, 9687.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy

Owyong, M., Chou, J., van den Bijgaart, R. J. E., Kong, N., Efe, G., Maynard, C., Talmi-Frank, D., Solomonov, I., Koopman, C., Hadler-Olsen, E., Headley, M., Lin, C., Wang, C. Y., Sagi, I., Werb, Z. & Plaks, V., Jan 1 2019, In : Life Science Alliance. 2, 6, e201800226.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

MPT0G413, A novel HDAC6-selective inhibitor, and bortezomib synergistically exert anti-tumor activity in multiple myeloma cells

Huang, F. I., Wu, Y. W., Sung, T. Y., Liou, J. P., Lin, M. H., Pan, S. L. & Yang, C. R., Jan 1 2019, In : Frontiers in Oncology. 9, APR, p. 249 249.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Mutation of the PTCH1 gene predicts recurrence of breast cancer

Wang, C. Y., Chang, Y. C., Kuo, Y. L., Lee, K. T., Chen, P. S., Cheung, C. H. A., Chang, C. P., Phan, N. N., Shen, M. R. & Hsu, H. P., Dec 1 2019, In : Scientific Reports. 9, 1, 16359.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Natural Antioxidant Resveratrol Suppresses Uterine Fibroid Cell Growth and Extracellular Matrix Formation In Vitro and In Vivo

Chen, H-Y., Lin, P-H., Shih, Y-H., Wang, K-L., Hong, Y-H., Shieh, T-M., Huang, T-C. & Hsia, S-M., Apr 1 2019, In : Antioxidants. 8, 4, 99.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Novel Common Genetic Susceptibility Loci for Colorectal Cancer

Schmit, S. L., Edlund, C. K., Schumacher, F. R., Gong, J., Harrison, T. A., Huyghe, J. R., Qu, C., Melas, M., Van Den Berg, D. J., Wang, H., Tring, S., Plummer, S. J., Albanes, D., Alonso, M. H., Amos, C. I., Anton, K., Aragaki, A. K., Arndt, V., Barry, E. L., Berndt, S. I. & 30 others, Bezieau, S., Bien, S., Bloomer, A., Boehm, J., Boutron-Ruault, M. C., Brenner, H., Brezina, S., Buchanan, D. D., Butterbach, K., Caan, B. J., Campbell, P. T., Carlson, C. S., Castelao, J. E., Chan, A. T., Chang-Claude, J., Chanock, S. J., Cheng, I., Cheng, Y. W., Chin, L. S., Church, J. M., Church, T., Coetzee, G. A., Cotterchio, M., Cruz Correa, M., Curtis, K. R., Duggan, D., Lin, Y., Liu, Y. R., Yen, Y. & Hsu, L., Feb 1 2019, In : Journal of the National Cancer Institute. 111, 2, p. 146-157 12 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Potential Effects of CXCL9 and CCL20 on Cardiac Fibrosis in Patients with Myocardial Infarction and Isoproterenol-Treated Rats

Lin, C-F., Su, C-J., Liu, J-H., Chen, S-T., Huang, H-L. & Pan, S-L., May 11 2019, In : Journal of Clinical Medicine. 8, 5

Research output: Contribution to journalArticle

PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression

Lang, Y. D., Chen, H. Y., Ho, C. M., Shih, J. H., Hsu, E. C., Shen, R., Lee, Y. C., Chen, J. W., Wu, C. Y., Yeh, H. W., Chen, R. H. & Jou, Y. S., Dec 1 2019, In : Nature Communications. 10, 1, 5716.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

RAB14 activates MARK signaling to promote bladder tumorigenesis

Chao, H., Deng, L., Xu, F., Fu, B., Zhu, Z., Dong, Z., Liu, Y-N. & Zeng, T., Feb 27 2019, In : Carcinogenesis.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Resveratrol antagonizes thyroid hormone-induced expression of checkpoint and proliferative genes in oral cancer cells

Lin, C. C., Chin, Y. T., Shih, Y. J., Chen, Y. R., Chung, Y. Y., Lin, C. Y., Hsiung, C. N., Whang-Peng, J., Lee, S. Y., Lin, H. Y., Davis, P. J. & Wang, K., Sep 1 2019, In : Journal of Dental Sciences. 14, 3, p. 255-262 8 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Rrm2b deletion causes mitochondrial metabolic defects in renal tubules

Chen, Y. F., Lin, I. H., Guo, Y. R., Chiu, W. J., Wu, M. S., Jia, W. & Yen, Y., Dec 1 2019, In : Scientific Reports. 9, 1, 1 p., 13238.

Research output: Contribution to journalArticle

Open Access

Structural insights to the heterotetrameric interaction between the vibrio parahaemolyticus pirA vp and pirB vp toxins and activation of the cry-like pore-forming domain

Lin, S. J., Chen, Y. F., Hsu, K. C., Chen, Y. L., Ko, T. P., Lo, C. F., Wang, H. C. & Wang, H. C., Apr 1 2019, In : Toxins. 11, 4, 233.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Synthesis and biological evaluation of anthra[1,9-cd]pyrazol-6(2H)-one scaffold derivatives as potential anticancer agents

Chen, T. C., Guh, J. H., Hsu, H. W., Chen, C. L., Lee, C. C., Wu, C. L., Lee, Y. R., Lin, J. J., Yu, D. S. & Huang, H. S., Dec 2019, In : Arabian Journal of Chemistry. 12, 8

Research output: Contribution to journalArticle

2 Citations (Scopus)

Synthesis and evaluation of new 3-substituted-4-chloro-thioxanthone derivatives as potent anti-breast cancer agents

Chen, C. L., Chen, T. C., Lee, C. C., Shih, L. C., Lin, C. Y., Hsieh, Y. Y., Ali, A. A. A. & Huang, H. S., Dec 2019, In : Arabian Journal of Chemistry. 12, 8

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Tetrac and NDAT Induce Anti-proliferation via Integrin αvβ3 in Colorectal Cancers With Different K-RAS Status

Chin, Y-T., He, Z-R., Chen, C-L., Chu, H-C., Ho, Y., Su, P-Y., Yang, Y-C. S. H., Wang, K., Shih, Y-J., Chen, Y-R., Pedersen, J. Z., Incerpi, S., Nana, A. W., Tang, H-Y., Lin, H-Y., Mousa, S. A., Davis, P. J. & Whang-Peng, J., Jan 1 2019, In : Frontiers in Endocrinology. 10, APR, p. 130 130.

Research output: Contribution to journalArticle

4 Citations (Scopus)

The Ambivalent Role of lncRNA Xist in Carcinogenesis

Chen, Y. K. & Yen, Y., Apr 15 2019, In : Stem Cell Reviews and Reports. 15, 2, p. 314-323 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

The synthetic retinoid ST1926 attenuates prostate cancer growth and potentially targets prostate cancer stem-like cells

Bahmad, H. F., Samman, H., Monzer, A., Hadadeh, O., Cheaito, K., Abdel-Samad, R., Hayar, B., Pisano, C., Msheik, H., Liu, Y-N., Darwiche, N. & Abou-Kheir, W., Jul 2019, In : Molecular Carcinogenesis. 58, 7, p. 1208-1220 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
Open Access
2018

1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC

Ojha, R., Huang, H. L., HuangFu, W. C., Wu, Y. W., Nepali, K., Lai, M. J., Su, C. J., Sung, T. Y., Chen, Y. L., Pan, S. L. & Liou, J. P., Apr 25 2018, In : European Journal of Medicinal Chemistry. 150, p. 667-677 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

2,3,5,4′-Tetrahydroxystilbene-2-O-β-glucoside potentiates self-renewal of human dental pulp stem cells via the AMPK/ERK/SIRT1 axis

Lin, C. Y., Chin, Y. T., Kuo, P. J., Lee, H. W., Huang, H. M., Lin, H. Y., Weng, I. T., Hsiung, C. N., Chan, Y. H. & Lee, S. Y., Oct 1 2018, In : International Endodontic Journal. 51, 10, p. 1159-1170 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy

Lin, S. Y., Yeh, T. K., Song, J. S., Hung, M. S., Cheng, M. F., Liao, F. Y., Li, A. S., Cheng, S. Y., Lin, L. M., Chiu, C. H., Wu, M. H., Lin, Y. J., Hsiao, W., Sun, M., Wang, Y. H., Huang, C. H., Tang, Y. C., Chang, H. H., Huang, Z. T., Chao, Y. S. & 5 others, Shih, C., Pan, S. L., Wu, S. Y., Kuo, C. C. & Ueng, S. H., Apr 1 2018, In : Bioorganic Chemistry. 77, p. 600-607 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes

Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Jan 29 2018, (Accepted/In press) In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Age, but not short-term intensive swimming, affects chondrocyte turnover in zebrafish vertebral cartilage

Jian, Q. L., HuangFu, W. C., Lee, Y. H. & Liu, I. H., Jan 1 2018, In : PeerJ. 2018, 10, e5739.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A homozygous variant in RRM2B is associated with severe metabolic acidosis and early neonatal death

Penque, B. A., Su, L., Wang, J., Ji, W., Bale, A., Luh, F., Fulbright, R. K., Sarmast, U., Sega, A. G., Konstantino, M., Spencer-Manzon, M., Pierce, R., Yen, Y. & Lakhani, S. A., Jan 1 2018, (Accepted/In press) In : European Journal of Medical Genetics.

Research output: Contribution to journalArticle

A low microRNA-630 expression confers resistance to tyrosine kinase inhibitors in EGFR-mutated lung adenocarcinomas via miR-630/YAP1/ERK feedback loop

Wu, D. W., Wang, Y. C., Wang, L., Chen, C. Y. & Lee, H., Jan 1 2018, In : Theranostics. 8, 5, p. 1256-1269 14 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Amentoflavone inhibits hepatocellular carcinoma progression through blockage of ERK/NF-κB activation

Lee, K. C., Chen, W. T., Liu, Y. C., Lin, S. S. & Hsu, F. T., Sep 1 2018, In : In Vivo. 32, 5, p. 1097-1103 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
9 Citations (Scopus)

A new niclosamide derivatives-B17 can inhibit urological cancers growth through apoptosis-related pathway

Wu, C-L., Chen, C-L., Huang, H-S. & Yu, D-S., Jun 28 2018, In : Cancer Medicine.

Research output: Contribution to journalArticle

1 Citation (Scopus)

A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo

Wu, Y. W., Hsu, K. C., Lee, H. Y., Huang, T. C., Lin, T. E., Chen, Y. L., Sung, T. Y., Liou, J. P., Hwang-Verslues, W. W., Pan, S. L. & HuangFu, W. C., Mar 13 2018, In : Frontiers in Pharmacology. 9, MAR, 205.

Research output: Contribution to journalArticle

3 Citations (Scopus)

A Novel Selective JAK2 Inhibitor Identified Using Pharmacological Interactions

Lin, T. E., HuangFu, W-C., Chao, M-W., Sung, T-Y., Chang, C-D., Chen, Y-Y., Hsieh, J-H., Tu, H-J., Huang, H-L., Pan, S-L. & Hsu, K-C., 2018, In : Frontiers in Pharmacology. 9, p. 1379

Research output: Contribution to journalArticle

Anti-TNF-α restricts dengue virus-induced neuropathy

Jhan, M. K., Huangfu, W. C., Chen, Y. F., Kao, J. C., Tsai, T. T., Ho, M. R., Shen, T. J., Tseng, P. C., Wang, Y. T. & Lin, C. F., Jan 1 2018, (Accepted/In press) In : Journal of Leukocyte Biology.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Application of bioconjugation chemistry on biosensor fabrication for detection of TAR-DNA binding protein 43

Dai, Y., Wang, C., Chiu, L. Y., Abbasi, K., Tolbert, B. S., Sauvé, G., Yen, Y. & Liu, C. C., Oct 15 2018, In : Biosensors and Bioelectronics. 117, p. 60-67 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction

Cheng, C. T., Qi, Y., Wang, Y. C., Chi, K. K., Chung, Y., Ouyang, C., Chen, Y. R., Oh, M. E., Sheng, X., Tang, Y., Liu, Y. R., Lin, H. H., Kuo, C. Y., Schones, D., Vidal, C. M., Chu, J. C. Y., Wang, H. J., Chen, Y. H., Miller, K. M., Chu, P. & 4 others, Yen, Y., Jiang, L., Kung, H. J. & Ann, D. K., Dec 1 2018, In : Communications Biology. 1, 1, 178.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Arthroprotective effects of Cf-02 sharing structural similarity with quercetin

Liu, F. C., Lu, J. W., Chien, C. Y., Huang, H. S., Lee, C. C., Lien, S. B., Lin, L. C., Chen, L. W., Ho, Y. J., Shen, M. C., Ho, L. J. & Lai, J. H., May 14 2018, In : International Journal of Molecular Sciences. 19, 5, 1453.

Research output: Contribution to journalArticle

4 Citations (Scopus)

A synergistic anti-cancer effect of troglitazone and lovastatin in a human anaplastic thyroid cancer cell line and in a mouse xenograft model

Zhong, W. B., Tsai, Y. C., Chin, L. H., Tseng, J. H., Tang, L. W., Horng, S., Fan, Y. C. & Hsu, S. P., Jul 1 2018, In : International Journal of Molecular Sciences. 19, 7, 1834.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Autophagic reliance promotes metabolic reprogramming in oncogenic KRAS-driven tumorigenesis

Lin, H. H., Chung, Y., Cheng, C. T., Ouyang, C., Fu, Y., Kuo, C. Y., Chi, K. K., Sadeghi, M., Chu, P., Kung, H. J., Li, C. F., Limesand, K. H. & Ann, D. K., Sep 2 2018, In : Autophagy. 14, 9, p. 1481-1498 18 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) promotes EGF receptor signaling of oral squamous cell carcinoma metastasis via the complex N-glycosylation

Chiang, W. F., Cheng, T. M., Chang, C. C., Pan, S. H., Changou, C. A., Chang, T. H., Lee, K. H., Wu, S. Y., Chen, Y. F., Chuang, K. H., Shieh, D. B., Chen, Y. L., Tu, C. C., Tsui, W. L. & Wu, M. H., Jan 4 2018, In : Oncogene. 37, 1, p. 116-127 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

CCN6-mediated MMP-9 activation enhances metastatic potential of human chondrosarcoma

Tzeng, H. E., Tang, C. H., Wu, S. H., Chen, H. T., Fong, Y. C., Lu, Y. C., Chen, W. C., Huang, H. D., Lin, C. Y. & Wang, S. W., Oct 1 2018, In : Cell Death and Disease. 9, 10, 955.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Characterization of chicken-derived single chain antibody fragments against venom of Naja naja atra

Lee, C. H., Leu, S. J., Lee, Y. C., Liu, C. I., Lin, L. T., Mwale, P. F., Chiang, J. R., Tsai, B. Y., Chen, C. C., Hung, C. S. & Yang, Y. Y., Oct 1 2018, In : Toxins. 10, 10, 383.

Research output: Contribution to journalArticle

3 Citations (Scopus)