Ph.D. Program for Cancer Molecular Biology and Drug Discovery

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output 1996 2020

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Article

The apoptotic mechanisms of MT-6, a mitotic arrest inducer, in human ovarian cancer cells

Chen, M. C., Kuo, Y. C., Hsu, C. M., Chen, Y. L., Shen, C. C., Teng, C. M. & Pan, S. L., Apr 7 2017, In : Scientific Reports. 7, 46149.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Apoptosis
Mitochondrial Membrane Potential
G2 Phase
G1 Phase

The Chinese Herbal Mixture Tien-Hsien Liquid Augments the Anticancer Immunity in Tumor Cell-Vaccinated Mice

Yang, P. M., Du, J. L., Wang, G. N. K., Chia, J. S., Hsu, W. B., Pu, P. C., Sun, A., Chiang, C. P. & Wang, W. B., Sep 1 2017, In : Integrative Cancer Therapies. 16, 3, p. 319-328 10 p.

Research output: Contribution to journalArticle

Immunity
Neoplasms
Natural Killer Cells
Cytotoxic T-Lymphocytes
Colonic Neoplasms
19 Citations (Scopus)

The chromatin modification by SUMO-2/3 but not SUMO-1 prevents the epigenetic activation of key immune-related genes during Kaposi's sarcoma associated herpesvirus reactivation

Chang, P. C., Cheng, C. Y., Campbell, M., Yang, Y. C., Hsu, H. W., Chang, T. Y., Chu, C. H., Lee, Y. W., Hung, C. L., Lai, S. M., Tepper, C. G., Hsieh, W. P., Wang, H. W., Tang, C. Y., Wang, W. C. & Kung, H. J., Nov 23 2013, In : BMC Genomics. 14, 1, 824.

Research output: Contribution to journalArticle

Human Herpesvirus 8
Epigenomics
Chromatin
Sumoylation
Herpesviridae
13 Citations (Scopus)

The combination of tetraiodothyroacetic acid and cetuximab inhibits cell proliferation in colorectal cancers with different K-ras status

Lee, Y. S., Chin, Y. T., Yang, Y. C. S. H., Wei, P. L., Wu, H. C., Shih, A., Lu, Y. T., Pedersen, J. Z., Incerpi, S., Liu, L. F., Lin, H. Y. & Davis, P. J., 2016, In : Steroids. p. 63-70

Research output: Contribution to journalArticle

Cell proliferation
Colorectal Neoplasms
Cell Proliferation
HCT116 Cells
Cyclin D1
3 Citations (Scopus)

The cytokine-cosmc signaling axis upregulates the tumorassociated carbohydrate antigen Tn

Ho, C. W., Lin, C. Y., Liaw, Y. W., Chiang, H. L., Chin, Y. T., Huang, R. L., Lai, H. C., Hsu, Y. W., Kuo, P. J., Chen, C. E., Lin, H. Y., Whang-Peng, J., Nieh, S., Fu, E., Liu, L. F. & Hwang, J., 2016, In : Oncotarget. 7, 38, p. 61930-61944 15 p.

Research output: Contribution to journalArticle

Up-Regulation
Carbohydrates
Cytokines
Conditioned Culture Medium
Inflammation
7 Citations (Scopus)

The effect of narrow bandwidth infrared radiation on the growth of Escherichia coli

Tsai, S. R., Huang, T. C., Liang, C. M., Chang, H. Y., Chang, Y. T., Huang, H. C., Juan, H. F. & Lee, S. C., Oct 17 2011, In : Applied Physics Letters. 99, 16, 163704.

Research output: Contribution to journalArticle

infrared radiation
Escherichia
bandwidth
wavelengths
transporter
1 Citation (Scopus)

The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes

Wang, Y. C., Chang, K. C., Lin, B. W., Lee, J. C., Lai, C. H., Lin, L. J., Yen, Y., Lin, C. S., Yang, S. J., Lin, P. C., Lee, C. T. & Hung, L. Y., Jun 1 2018, In : Experimental and Molecular Medicine. 50, 6, p. 70 70.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoproteins
cdc Genes
Epidermal Growth Factor
Carcinogenesis
Genes
7 Citations (Scopus)

The ethyl acetate fraction of corn silk exhibits dual antioxidant and anti-glycation activities and protects insulin-secreting cells from glucotoxicity

Chang, C. C., Yuan, W., Roan, H. Y., Chang, J. L., Huang, H. C., Lee, Y. C., Tsay, H. J. & Liu, H. K., Nov 3 2016, In : BMC Complementary and Alternative Medicine. 16, 1, 432.

Research output: Contribution to journalArticle

Silk
Insulin-Secreting Cells
Zea mays
Antioxidants
Insulin
46 Citations (Scopus)

The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells

Chen, M. C., Chen, C. H., Wang, J. C., Tsai, A. C., Liou, J. P., Pan, S. L. & Teng, C. M., Sep 2013, In : Cell Death and Disease. 4, 9, e810.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Epidermal Growth Factor Receptor
Cell Death
Protein-Tyrosine Kinases
erbB-1 Genes
9 Citations (Scopus)

The Impact of dUTPase on Ribonucleotide Reductase-Induced Genome Instability in Cancer Cells

Chen, C. W., Tsao, N., Huang, L. Y., Yen, Y., Liu, X., Lehman, C., Wang, Y. H., Tseng, M. C., Chen, Y. J., Ho, Y. C., Chen, C. F. & Chang, Z. F., Aug 2 2016, In : Cell Reports. 16, 5, p. 1287-1299 13 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Genomic Instability
Genes
Cells
Genome
4 Citations (Scopus)

The indazole derivative YD-3 specifically inhibits thrombin-induced angiogenesis in vitro and in vivo

Peng, C. Y., Pan, S. L., Pai, H. C., Tsai, A. C., Guh, J. H., Chang, Y. L., Kuo, S. C., Lee, F. Y. & Teng, C. M., Dec 2010, In : Shock. 34, 6, p. 580-585 6 p.

Research output: Contribution to journalArticle

Indazoles
Thrombin
PAR-1 Receptor
Endothelial Cells
Cell Proliferation
7 Citations (Scopus)

The inhibition of angiogenesis and tumor growth by denbinobin is associated with the blocking of insulin-like growth factor-1 receptor signaling

Tsai, A. C., Pan, S. L., Lai, C. Y., Wang, C. Y., Chen, C. C., Shen, C. C. & Teng, C. M., Jul 2011, In : Journal of Nutritional Biochemistry. 22, 7, p. 625-633 9 p.

Research output: Contribution to journalArticle

Somatomedin Receptors
Somatomedins
Tumors
Growth
Neoplasms
9 Citations (Scopus)
Glycyrrhiza
licorice
doxorubicin
autophagy
Autophagy
26 Citations (Scopus)

The mechanisms by which pardaxin, a natural cationic antimicrobial peptide, targets the endoplasmic reticulum and induces c-FOS

Ting, C. H., Huang, H. N., Huang, T. C., Wu, C. J. & Chen, J. Y., Apr 2014, In : Biomaterials. 35, 11, p. 3627-3640 14 p.

Research output: Contribution to journalArticle

Antimicrobial Cationic Peptides
Cell death
Endoplasmic Reticulum
Peptides
Transcription factors
4 Citations (Scopus)

The monomeric form of Neisseria DNA mimic protein DMP19 prevents DNA from binding to the histone-like HU protein

Huang, M. F., Lin, S. J., Ko, T. P., Liao, Y. T., Hsu, K. C. & Wang, H. C., Dec 1 2017, In : PLoS One. 12, 12, e0189461.

Research output: Contribution to journalArticle

Neisseria
histones
Histones
DNA
Dimers
32 Citations (Scopus)

The MZF1/c-MYC axis mediates lung adenocarcinoma progression caused by wild-type lkb1 loss

Tsai, L. H., Wu, J. Y., Cheng, Y. W., Chen, C. Y., Sheu, G. T., Wu, T. C. & Lee, H., Mar 26 2015, In : Oncogene. 34, 13, p. 1641-1649 9 p.

Research output: Contribution to journalArticle

Phosphotransferases
Liver
Neoplasms
Adenocarcinoma of lung
Mutation
11 Citations (Scopus)

The novel ribonucleotide reductase inhibitor COH29 inhibits DNA repair in vitros

Chen, M. C., Zhou, B., Zhang, K., Yuan, Y. C., Un, F., Hu, S., Chou, C. M., Chen, C. H., Wu, J., Wang, Y., Liu, X., Smith, D. L., Li, H., Liu, Z., Warden, C. D., Su, L., Malkas, L. H., Chung, Y. M., Hu, M. C. T. & Yen, Y., Jun 1 2015, In : Molecular Pharmacology. 87, 6, p. 996-1005 10 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
DNA Repair
DNA Damage
gemcitabine
Deoxyribonucleotides
19 Citations (Scopus)

The pan-PI3K inhibitor GDC-0941 activates canonical WNT signaling to confer resistance in TNBC cells: Resistance reversal with WNT inhibitor

Tzeng, H. E., Yang, L., Chen, K., Wang, Y., Liu, Y. R., Pan, S. L., Gaur, S., Hu, S. & Yen, Y., 2015, In : Oncotarget. 6, 13, p. 11061-11073 13 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Phosphatidylinositol 3-Kinases
beta Catenin
MCF-7 Cells
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
39 Citations (Scopus)

The prognostic significance of APC gene mutation and miR-21 expression in advanced-stage colorectal cancer

Chen, T. H., Chang, S. W., Huang, C. C., Wang, K. L., Yeh, K. T., Liu, C. N., Lee, H., Lin, C. C. & Cheng, Y. W., Nov 2013, In : Colorectal Disease. 15, 11, p. 1367-1374 8 p.

Research output: Contribution to journalArticle

APC Genes
Colorectal Neoplasms
Mutation
Taiwan
Gene Expression
9 Citations (Scopus)

The prognostic value of ribonucleotide reductase small subunit M2 in predicting recurrence for prostate cancers

Huang, Y., Liu, X., Wang, Y. H., Yeh, S. D., Chen, C. L., Nelson, R. A., Chu, P., Wilson, T. & Yen, Y., Jan 2014, In : Urologic Oncology: Seminars and Original Investigations. 32, 1

Research output: Contribution to journalArticle

Prostatic Neoplasms
Recurrence
Capsules
Neoplasm Grading
Metalloproteases
46 Citations (Scopus)

The protective effect of alstonia scholaris r. br. on hepatotoxin-induced acute liver damage

Lin, S. C., Lin, C. C., Lin, Y. H., Supriyatna, S. & Pan, S. L., 1996, In : American Journal of Chinese Medicine. 24, 2, p. 153-164 12 p.

Research output: Contribution to journalArticle

Alstonia
Galactosamine
Liver
Acetaminophen
Transaminases
11 Citations (Scopus)

Therapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS

Chang, C-F., Lee, Y-C., Lee, K-H., Lin, C. H., Chen, C-L., Shen, C. K. J. & Huang, C-C., Oct 21 2016, In : Journal of Biomedical Science. 23, 1, 72.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Berberine
Therapeutic Uses
Autophagy
TDP-43 Proteinopathies
Peroxynitrous Acid
Cyclooxygenase 2
Superoxide Dismutase
Skin
HIV
virtual reality
Observation
Learning
energy
learning
13 Citations (Scopus)

The role of interleukin-10 in the progression of human papillomavirus-associated lung carcinoma

Sung, W. W. & Lee, H., 2013, In : OncoImmunology. 2, 9, e25854.

Research output: Contribution to journalArticle

Interleukin-10
Carcinoma
Phosphatidylinositol 3-Kinases
Lung
Neoplasms
6 Citations (Scopus)

The simultaneous inhibitory effect of niclosamide on RANKL-induced osteoclast formation and osteoblast differentiation

Liu, F. L., Chen, C. L., Lee, C. C., Wu, C. C., Hsu, T. H., Tsai, C. Y., Huang, H. S. & Chang, D. M., 2017, In : International Journal of Medical Sciences. 14, 9, p. 840-852 13 p.

Research output: Contribution to journalArticle

Niclosamide
Osteoclasts
Osteoblasts
Osteogenesis
Macrophage Colony-Stimulating Factor
26 Citations (Scopus)

The synergic effect of vincristine and vorinostat in leukemia in vitro and in vivo

Chao, M-W., Lai, M-J., Liou, J. P., Chang, Y-L., Wang, J-C., Pan, S. L. & Teng, C-M., Dec 12 2015, In : Journal of Hematology and Oncology. 8, 1, 176.

Research output: Contribution to journalArticle

Vincristine
Leukemia
Microtubules
Tubulin
Cell Survival
1 Citation (Scopus)

The synthetic retinoid ST1926 attenuates prostate cancer growth and potentially targets prostate cancer stem-like cells

Bahmad, H. F., Samman, H., Monzer, A., Hadadeh, O., Cheaito, K., Abdel-Samad, R., Hayar, B., Pisano, C., Msheik, H., Liu, Y-N., Darwiche, N. & Abou-Kheir, W., Jul 2019, In : Molecular Carcinogenesis. 58, 7, p. 1208-1220 13 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Retinoids
Prostatic Neoplasms
Growth
Apoptosis
15 Citations (Scopus)

The YAP1/SIX2 axis is required for DDX3-mediated tumor aggressiveness and cetuximab resistance in KRAS-wild-type colorectal cancer

Wu, D. W., Lin, P. L., Wang, L., Huang, C. C. & Lee, H., 2017, In : Theranostics. 7, 5, p. 1114-1132 19 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Neoplasms
Animal Models
Agar
Regression Analysis
23 Citations (Scopus)

Thrombin induces expression of twist and cell motility via the hypoxia-inducible factor-1α translational pathway in colorectal cancer cells

Chang, L. H., Chen, C-H., Huang, D. Y., Pai, H. C., Pan, S. L. & Teng, C. M., Apr 2011, In : Journal of Cellular Physiology. 226, 4, p. 1060-1068 9 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Thrombin
Cell Movement
Colorectal Neoplasms
PAR-1 Receptor
5 Citations (Scopus)

Thrombomodulin influences the survival of patients with non-metastatic colorectal cancer through epithelial-to-mesenchymal transition (EMT)

Chang, Y. J., Cheng, Y. W., Lin, R. K., Huang, C. C., Chen, W. T. L., Ke, T. W. & Wei, P. L., Aug 1 2016, In : PLoS One. 11, 8, e0160550.

Research output: Contribution to journalArticle

Thrombomodulin
Epithelial-Mesenchymal Transition
colorectal neoplasms
Colorectal Neoplasms
Survival
20 Citations (Scopus)

Thrombospondin-2 promotes prostate cancer bone metastasis by the up-regulation of matrix metalloproteinase-2 through down-regulating miR-376c expression

Chen, P. C., Tang, C. H., Lin, L. W., Tsai, C. H., Chu, C. Y., Lin, T. H. & Huang, Y. L., Jan 25 2017, In : Journal of Hematology and Oncology. 10, 1, 33.

Research output: Contribution to journalArticle

Bone Neoplasms
Matrix Metalloproteinase 2
MicroRNAs
Prostatic Neoplasms
Up-Regulation
18 Citations (Scopus)

Thyroid hormone inhibition in L6 myoblasts of IGF-I-mediated glucose uptake and proliferation: New roles for integrin αvβ3

Incerpi, S., Hsieh, M. T., Lin, H. Y., Cheng, G. Y., De Vito, P., Fiore, A. M., Ahmed, R. G., Salvia, R., Candelotti, E., Leone, S., Luly, P., Pedersen, J. Z., Davis, F. B. & Davis, P. J., Jul 15 2014, In : American Journal of Physiology - Cell Physiology. 307, 2

Research output: Contribution to journalArticle

Myoblasts
Insulin-Like Growth Factor I
Thyroid Hormones
Integrins
Glucose
8 Citations (Scopus)

Thyroid Hormone in the Clinic and Breast Cancer

Hercbergs, A., Mousa, S. A., Leinung, M., Lin, H. Y. & Davis, P. J., Feb 13 2018, (Accepted/In press) In : Hormones and Cancer. p. 1-5 5 p.

Research output: Contribution to journalArticle

Thyroid Hormones
Breast Neoplasms
Thyronines
Hypothyroidism
Thyroxine
8 Citations (Scopus)

Thyroid Hormone Promotes β-Catenin Activation and Cell Proliferation in Colorectal Cancer

Lee, Y. S., Chin, Y. T., Shih, Y. J., Nana, A. W., Chen, Y. R., Wu, H. C., Yang, Y. C. S. H., Lin, H. Y. & Davis, P. J., Jan 29 2018, (Accepted/In press) In : Hormones and Cancer. p. 1-10 10 p.

Research output: Contribution to journalArticle

Catenins
Thyroid Hormones
Colorectal Neoplasms
Cell Proliferation
Gene Expression
9 Citations (Scopus)

Thyroid hormones crosstalk with growth factors: Old facts and new hypotheses

Candelotti, E., Vito, P. D., Ahmed, R. G., Luly, P., Davis, P. J., Pedersen, J. Z., Lin, H. Y. & Incerpi, S., Jul 1 2015, In : Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry. 15, 1, p. 71-85 15 p.

Research output: Contribution to journalArticle

Thyroid Hormones
Intercellular Signaling Peptides and Proteins
Integrins
Interleukins
Cell Membrane
20 Citations (Scopus)

Thyroxine inhibits resveratrol-caused apoptosis by PD-L1 in ovarian cancer cells

Chin, Y. T., Wei, P. L., Ho, Y., Nana, A. W., Changou, C. A., Chen, Y. R., Yang, Y. C. SH., Hsieh, M. T., Hercbergs, A., Davis, P. J., Shih, Y. J. & Lin, H. Y., May 1 2018, In : Endocrine-Related Cancer. 25, 5, p. 533-545 13 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Thyroxine
Ovarian Neoplasms
Apoptosis
Ligands
15 Citations (Scopus)

Time Trend of Multiple Myeloma and Associated Secondary Primary Malignancies in Asian Patients: A Taiwan Population-Based Study

Tzeng, H. E., Lin, C. L., Tsai, C. H., Tang, C. H., Hwang, W. L., Cheng, Y. W., Sung, F. C. & Chung, C. J., Jul 2 2013, In : PLoS One. 8, 7, e68041.

Research output: Contribution to journalArticle

myeloma
Multiple Myeloma
Taiwan
Hematologic Neoplasms
Population
Open Access
Tissue Inhibitor of Metalloproteinase-3
Colorectal Neoplasms
Neoplasm Metastasis
Growth
Neoplasms
4 Citations (Scopus)
Acetylgalactosamine
Hyperoxia
NF-kappa B
Lung Injury
Threonine
5 Citations (Scopus)
Hemorrhoidectomy
Diltiazem
Ointments
Meta-Analysis
Randomized Controlled Trials
1 Citation (Scopus)

Total synthesis and metabolic stability of hispidulin and its d-labelled derivative

Chen, L. C., Hsu, K. C., Chiou, L. C., Tseng, H. J. & Huang, W. J., Nov 1 2017, In : Molecules. 22, 11, 1897.

Research output: Contribution to journalArticle

Derivatives
central nervous system
synthesis
liver
flavone
50 Citations (Scopus)

Transforming growth factor-β promotes prostate bone metastasis through induction of microRNA-96 and activation of the mTOR pathway

Siu, M. K., Tsai, Y. C., Chang, Y. S., Yin, J. J., Suau, F., Chen, W. Y. & Liu, Y. N., Sep 3 2015, In : Oncogene. 34, 36, p. 4767-4776 10 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Sirolimus
MicroRNAs
Prostate
Neoplasm Metastasis
9 Citations (Scopus)
Urinary Bladder Neoplasms
Autophagy
G1 Phase Cell Cycle Checkpoints
cdc Genes
Cyclin E
23 Citations (Scopus)

Tumor suppressor FOXO3 regulates ribonucleotide reductase subunit RRM2B and impacts on survival of cancer patients

Cho, E. C., Kuo, M. L., Liu, X., Yang, L., Hsieh, Y. C., Wang, J., Cheng, Y. & Yen, Y., 2014, In : Oncotarget. 5, 13, p. 4834-4844 11 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Survival
Neoplasms
DNA Replication
Tumor Biomarkers

TW-01, a piperazinedione-derived compound, inhibits Ras-mediated cell proliferation and angioplasty-induced vascular restenosis

Lin, C. F., Huang, H. L., Peng, C. Y., Lee, Y. C., Wang, H. P., Teng, C. M. & Pan, S. L., Aug 15 2016, In : Toxicology and Applied Pharmacology. 305, p. 194-202 9 p.

Research output: Contribution to journalArticle

3,6-bis(5-chloro-2-piperidyl)-2,5-piperazinedione
Cell proliferation
Angioplasty
Blood Vessels
Cell Proliferation
13 Citations (Scopus)

TW01001, a novel piperazinedione compound, induces mitotic arrest and autophagy in non-small cell lung cancer A549 cells

Chen, M. C., Chen, C. H., Liu, Y. N., Wang, H. P., Pan, S. L. & Teng, C. M., Aug 19 2013, In : Cancer Letters. 336, 2, p. 370-378 9 p.

Research output: Contribution to journalArticle

3,6-bis(5-chloro-2-piperidyl)-2,5-piperazinedione
Autophagy
Non-Small Cell Lung Carcinoma
G2 Phase
Cell Division
7 Citations (Scopus)

Tyrosine kinase inhibitors for advanced or metastatic thyroid cancer: a meta-analysis of randomized controlled trials

Liu, J. W., Chen, C., Loh, E. W., Chu, C. C., Wang, M. Y., Ouyang, H. J., Chang, Y. T., Zhuang, W. Z., Chou, C. W., Huang, D. J., Lee, C. H., Yen, Y. & Tam, K. W., 2018, In : Current Medical Research and Opinion. p. 1-9 9 p.

Research output: Contribution to journalArticle

Thyroid Neoplasms
Protein-Tyrosine Kinases
Meta-Analysis
Randomized Controlled Trials
Confidence Intervals
23 Citations (Scopus)

Underexpression of LKB1 tumor suppressor is associated with enhanced Wnt signaling and malignant characteristics of human intrahepatic cholangiocarcinoma

Wang, J., Zhang, K., Wang, J., Wu, X., Liu, X., Li, B., Zhu, Y., Yu, Y., Cheng, Q., Hu, Z., Guo, C., Hu, S., Mu, B., Tsai, C. H., Li, J., Smith, L., Yang, L., Liu, Q., Chu, P., Chang, V. & 4 others, Zhang, B., Wu, M., Jiang, X. & Yen, Y., 2015, In : Oncotarget. 6, 22, p. 18905-18920 16 p.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Phosphotransferases
Liver
Catenins
Neoplasms
13 Citations (Scopus)

Upregulation of endocan by epstein-barr virus latent membrane protein 1 and its clinical significance in nasopharyngeal Carcinoma

Yu, P. H., Chou, S. F., Chen, C. L., Hung, H., Lai, C. Y., Yang, P. M., Jeng, Y. M., Liaw, S. F., Kuo, H. H., Hsu, H. C., Chen, J. Y. & Wang, W. B., Dec 5 2013, In : PLoS One. 8, 12, e82254.

Research output: Contribution to journalArticle

Human herpesvirus 4
membrane proteins
carcinoma
Membrane Proteins
Up-Regulation