Ph.D. Program for Cancer Molecular Biology and Drug Discovery

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output 1996 2020

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15 Citations (Scopus)

Expression of glypican 3 enriches hepatocellular carcinoma development-related genes and associates with carcinogenesis in cirrhotic livers

Liu, X., Wang, S. K., Zhang, K., Zhang, H., Pan, Q., Liu, Z., Pan, H., Xue, L., Yen, Y. & Chu, P. G., Aug 20 2014, In : Carcinogenesis. 36, 2, p. 232-242 11 p.

Research output: Contribution to journalArticle

Glypicans
Hepatocellular Carcinoma
Carcinogenesis
Liver
Genes
13 Citations (Scopus)

Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1/Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer

Chen, I. C., Lee, K. H., Hsu, Y. H., Wang, W. R., Chen, C. M. & Cheng, Y. W., 2016, In : Disease Markers. 2016, 8169724.

Research output: Contribution to journalArticle

Tryptophan Oxygenase
Indoleamine-Pyrrole 2,3,-Dioxygenase
Colorectal Neoplasms
beta Catenin
Proteins
15 Citations (Scopus)
Unfolded Protein Response
Autophagy
Colorectal Neoplasms
Up-Regulation
Endoplasmic Reticulum Stress
27 Citations (Scopus)

FHIT loss confers cisplatin resistance in lung cancer via the AKT/NF-κB/Slug-mediated PUMA reduction

Wu, D. W., Lee, M. C., Hsu, N. Y., Wu, T. C., Wu, J. Y., Wang, Y. C., Cheng, Y. W., Chen, C. Y. & Lee, H., May 7 2015, In : Oncogene. 34, 19, p. 2505-2515 11 p.

Research output: Contribution to journalArticle

Gastropoda
Histidine
Cisplatin
Lung Neoplasms
Non-Small Cell Lung Carcinoma
36 Citations (Scopus)

Fluorescence-guided probes of aptamer-targeted gold nanoparticles with computed tomography imaging accesses for in vivo tumor resection

Li, C. H., Kuo, T. R., Su, H. J., Lai, W. Y., Yang, P. C., Chen, J. S., Wang, D. Y., Wu, Y. C. & Chen, C. C., Oct 28 2015, In : Scientific Reports. 5, 15675.

Research output: Contribution to journalArticle

Gold
Nanoparticles
Fluorescence
Tomography
Neoplasms
Mouth Neoplasms
Oncogene Proteins
Lung Neoplasms
Neoplasms
Thiostrepton
24 Citations (Scopus)

Frequent overexpression of HMGA2 in human atypical teratoid/rhabdoid tumor and its correlation with let-7a3/let-7b miRNA

Zhang, K., Gao, H., Wu, X., Wang, J., Zhou, W., Sun, G., Wang, J., Wang, Y., Mu, B., Kim, C., Chu, P., Ho, D. M., Ann, D. K., Wong, T. T. & Yen, Y., 2014, In : Clinical Cancer Research. 20, 5, p. 1179-1189 11 p.

Research output: Contribution to journalArticle

AT-Hook Motifs
MicroRNAs
Oncogene Proteins
Immunohistochemistry
Typical Teratoid Rhabdoid Tumor
4 Citations (Scopus)

Fucoidan Inhibits the Proliferation of Leiomyoma Cells and Decreases Extracellular Matrix-Associated Protein Expression

Chen, H. Y., Huang, T. C., Lin, L. C., Shieh, T. M., Wu, C. H., Wang, K. L., Hong, Y. H. & Hsia, S. M., Oct 1 2018, In : Cellular Physiology and Biochemistry. 49, 5, p. 1970-1986 17 p.

Research output: Contribution to journalArticle

Extracellular Matrix Proteins
Leiomyoma
Cell Proliferation
Heterografts
Neoplasms
31 Citations (Scopus)

Furanylazaindoles: Potent anticancer agents in vitro and in vivo

Lee, H. Y., Pan, S. L., Su, M-C., Liu, Y-M., Kuo, C-C., Chang, Y-T., Wu, J-S., Nien, C-Y., Mehndiratta, S., Chang, C-Y., Wu, S-Y., Lai, M-J., Chang, J-Y. & Liou, J. P., 2013, In : Journal of Medicinal Chemistry. 56, 20, p. 8008-8018 11 p.

Research output: Contribution to journalArticle

Tubulin
Antineoplastic Agents
Body Weight Changes
G2 Phase
Colchicine
1 Citation (Scopus)

Generation and characterization of avian-derived anti-human CD19 single chain fragment antibodies

Tsai, K. C., Chiang, C. W., Lo, Y. N., Chang, F. L., Lin, T. Y., Chang, C. Y., Chen, W. C. & Lee, Y. C., Jan 1 2018, (Accepted/In press) In : Animal Biotechnology.

Research output: Contribution to journalArticle

Complementarity Determining Regions
Single-Chain Antibodies
Immunoglobulin Fragments
Antibodies
Chickens
2 Citations (Scopus)

Global DNA methylation analysis reveals miR-214-3p contributes to cisplatin resistance in pediatric intracranial nongerminomatous malignant germ cell tumors

Hsieh, T. H., Liu, Y. R., Chang, T. Y., Liang, M. L., Chen, H. H., Wang, H. W., Yen, Y. & Wong, T-T., Mar 27 2018, In : Neuro-Oncology. 20, 4, p. 519-530 12 p.

Research output: Contribution to journalArticle

Germ Cell and Embryonal Neoplasms
Germinoma
DNA Methylation
Cisplatin
MicroRNAs
2 Citations (Scopus)

Glucocorticoids may compromise the effect of gefitinib in non-small cell lung cancer

Wang, H. Y., Chang, Y. L., Cheng, C. C., Chao, M. W., Lin, S. I., Pan, S-L., Hsu, C. C., Liu, T. W., Cheng, H. C., Tseng, C. P., Liu, S. J., Tsai, H. J., Chang, H. Y. & Hsu, J. T. A., 2016, In : Oncotarget. 7, 52, p. 85917-85928 12 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Glucocorticoids
Protein-Tyrosine Kinases
Epidermal Growth Factor Receptor
Heterografts
10 Citations (Scopus)

Gluconeogenesis, lipogenesis, and HBV replication are commonly regulated by PGC-1α-dependent pathway

Jhuang, H. J., Hsu, W. H., Lin, K. T., Hsu, S. L., Wang, F. S., Chou, C. K., Lee, K. H., Tsou, A. P., Lai, J. M., Yeh, S. F. & Huang, C. Y. F., 2015, In : Oncotarget. 6, 10, p. 7788-7803 16 p.

Research output: Contribution to journalArticle

Lipogenesis
Gluconeogenesis
Virus Replication
Hepatitis B virus
Glucocorticoids
12 Citations (Scopus)

Glucose-regulated protein 94 mediates cancer progression via AKT and eNOS in hepatocellular carcinoma

Huang, C. Y., Batzorig, U., Cheng, W. L., Huang, M. T., Chen, W. Y., Wei, P. L. & Chang, Y. J., Apr 1 2016, In : Tumor Biology. 37, 4, p. 4295-4304

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Neoplasms
glucose-regulated proteins
AMP-Activated Protein Kinases
Heterografts
Open Access
Cell Cycle Proteins
Epithelial-Mesenchymal Transition
regulators
Prostatic Neoplasms
genes
8 Citations (Scopus)
Neuropilin-1
Galectin 1
Hepatic Stellate Cells
Platelet-Derived Growth Factor
Transforming Growth Factors
6 Citations (Scopus)
AT-Hook Motifs
HSP90 Heat-Shock Proteins
Epithelial-Mesenchymal Transition
Hooks
colorectal neoplasms
2 Citations (Scopus)

Hepatitis B virus X protein represses LKB1 expression to promote tumor progression and poor postoperative outcome in hepatocellular carcinoma

Wu, C. C., Wu, D. W., Lin, Y. Y., Lin, P. L. & Lee, H., Jan 1 2018, (Accepted/In press) In : Surgery (United States).

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Phosphotransferases
Liver
Neoplasms
Protein Kinases
18 Citations (Scopus)

Heteronemin, a spongean sesterterpene, induces cell apoptosis and autophagy in human renal carcinoma cells

Wu, S. Y., Sung, P. J., Chang, Y. L., Pan, S. L. & Teng, C. M., 2015, In : BioMed Research International. 2015, 738241.

Research output: Contribution to journalArticle

Sesterterpenes
Autophagy
Renal Cell Carcinoma
Cells
Apoptosis
2 Citations (Scopus)

Heteronemin induces anti-Proliferation in cholangiocarcinoma cells via inhibiting TGF-β pathway

Lin, H. Y., Tey, S. L., Ho, Y., Chin, Y. T., Wang, K., Whang-Peng, J., Shih, Y. J., Chen, Y. R., Yang, Y. N., Chen, Y. C., Liu, Y. C., Tang, H. Y. & Yang, Y. C. SH., Dec 6 2018, In : Marine Drugs. 16, 12, 489.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Transforming Growth Factors
Neoplasm Metastasis
Cell Adhesion
Cell Movement
6 Citations (Scopus)

HIF-1-alpha links mitochondrial perturbation to the dynamic acquisition of breast cancer tumorigenicity

Kuo, C. Y., Cheng, C. T., Hou, P., Lin, Y. P., Ma, H., Chung, Y., Chi, K., Chen, Y., Li, W., Kung, H. J. & Ann, D. K., Jun 7 2016, In : Oncotarget. 7, 23, p. 34052-34069 18 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Breast Neoplasms
Fumarates
Succinic Acid
Hypoxia-Inducible Factor-Proline Dioxygenases
81 Citations (Scopus)

High PD-L1 expression correlates with metastasis and poor prognosis in oral squamous cell carcinoma

Lin, Y. M., Sung, W. W., Hsieh, M. J., Tsai, S. C., Lai, H. W., Yang, S. M., Shen, K. H., Chen, M. K., Lee, H., Yeh, K. T. & Chen, C. J., Nov 1 2015, In : PLoS One. 10, 11, e0142656.

Research output: Contribution to journalArticle

squamous cell carcinoma
metastasis
prognosis
Squamous Cell Carcinoma
mouth

Histone demethylase KDM4C stimulates the proliferation of prostate cancer cells via activation of AKT and c-Myc

Lin, C. Y., Wang, B. J., Chen, B. C., Tseng, J. C., Jiang, S. S., Tsai, K. K., Shen, Y. Y., Yuh, C. H., Sie, Z. L., Wang, W. C., Kung, H. J. & Chuu, C. P., Nov 2019, In : Cancers. 11, 11, 1785.

Research output: Contribution to journalArticle

Open Access
Histone Demethylases
Prostatic Neoplasms
Prostate
Androgen Receptors
Cell Proliferation
7 Citations (Scopus)

HMGB1 genetic polymorphisms are biomarkers for the development and progression of breast cancer

Huang, B. F., Tzeng, H. E., Chen, P. C., Wang, C. Q., Su, C. M., Wang, Y., Hu, G. N., Zhao, Y. M., Wang, Q. & Tang, C. H., Mar 12 2018, In : International Journal of Medical Sciences. 15, 6, p. 580-586 7 p.

Research output: Contribution to journalArticle

HMGB1 Protein
Genetic Polymorphisms
Biomarkers
Breast Neoplasms
Triple Negative Breast Neoplasms
24 Citations (Scopus)

Human mitochondrial pyrroline-5-carboxylate reductase 1 promotes invasiveness and impacts survival in breast cancers

Ding, J., Kuo, M. L., Su, L., Xue, L., Luh, F., Zhang, H., Wang, J., Lin, T. G., Zhang, K., Chu, P., Zheng, S., Liu, X. & Yen, Y., May 1 2017, In : Carcinogenesis. 38, 5, p. 519-531 13 p., bgx022.

Research output: Contribution to journalArticle

Breast Neoplasms
Survival
Estrogen Receptors
Messenger RNA
Pyrroline Carboxylate Reductases
33 Citations (Scopus)

Human papilloma virus 16 E6 oncoprotein associated with p53 inactivation in colorectal cancer

Chen, T. H., Huang, C. C., Yeh, K. T., Chang, S. H., Chang, S. W., Sung, W. W., Cheng, Y. W. & Lee, H., 2012, In : World Journal of Gastroenterology. 18, 30, p. 4051-4058 8 p.

Research output: Contribution to journalArticle

Papillomaviridae
Oncogene Proteins
Colorectal Neoplasms
Neoplasms
DNA
17 Citations (Scopus)

Human Papillomavirus Up-Regulates MMP-2 and MMP-9 Expression and Activity by Inducing Interleukin-8 in Lung Adenocarcinomas

Shiau, M. Y., Fan, L. C., Yang, S. C., Tsao, C. H., Lee, H., Cheng, Y. W., Lai, L. C. & Chang, Y. H., Jan 21 2013, In : PLoS One. 8, 1, e54423.

Research output: Contribution to journalArticle

gelatinase A
gelatinase B
Papillomaviridae
interleukin-8
adenocarcinoma
3 Citations (Scopus)

Identification and preclinical evaluation of the small molecule, NSC745887, for treating glioblastomas via suppressing DcR3- associated signaling pathways

Fann, L. Y., Chen, Y., Chu, D. C., Weng, S. J., Chu, H. C., Wu, A. T. H., Lee, J. F., Ali, A. A. A., Chen, T. C., Huang, H. S. & Ma, K. H., Jan 1 2018, In : Oncotarget. 9, 15, p. 11922-11937 16 p.

Research output: Contribution to journalArticle

Glioblastoma
Brain Neoplasms
Caspase 3
Ataxia Telangiectasia Mutated Proteins
Staining and Labeling

Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation

Chang, L. C., Chen, T. C., Chen, S. J., Chen, C. L., Lee, C. C., Wu, S. H., Yen, Y., Huang, H. S. & Lin, J. J., Oct 18 2016, In : Oncotarget. 7, 42, p. 67986-68001 16 p.

Research output: Contribution to journalArticle

G-Quadruplexes
Cell Movement
Neoplasms
Wnt Signaling Pathway
Excipients
2 Citations (Scopus)

Identification of Inhibitors for the DEDDh Family of Exonucleases and a Unique Inhibition Mechanism by Crystal Structure Analysis of CRN-4 Bound with 2-Morpholin-4-ylethanesulfonate (MES)

Huang, K. W., Hsu, K. C., Chu, L. Y., Yang, J. M., Yuan, H. S. & Hsiao, Y. Y., Sep 8 2016, In : Journal of Medicinal Chemistry. 59, 17, p. 8019-8029 11 p.

Research output: Contribution to journalArticle

Exonucleases
Lassa Fever
Lassa virus
Viral Proteins
Virus Replication
4 Citations (Scopus)

Identification of neuraminidase inhibitors against dual H274Y/I222R mutant strains

Hsu, K. C., Hung, H. C., Huangfu, W. C., Sung, T. Y., Eight Lin, T., Fang, M. Y., Chen, I. J., Pathak, N., Hsu, J. T. A. & Yang, J. M., Dec 1 2017, In : Scientific Reports. 7, 1, 12336.

Research output: Contribution to journalArticle

Neuraminidase
Saliva
Binding Sites
Pharmaceutical Preparations
Human Influenza

Identification of two independent SUMO-interacting motifs in Fas-associated factor 1 (FAF1): Implications for mineralocorticoid receptor (MR)-mediated transcriptional regulation

Wang, C. H., Hung, P. W., Chiang, C. W., Lombès, M., Chen, C. H., Lee, K. H., Lo, Y. C., Wu, M. H., Chang, W. C. & Lin, D. Y., Aug 1 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 8, p. 1282-1297 16 p.

Research output: Contribution to journalArticle

Mineralocorticoid Receptors
Ubiquitin
Catenins
Aldosterone
Transcriptional Activation
36 Citations (Scopus)

IL-10 promotes tumor aggressiveness via upregulation of CIP2A transcription in lung adenocarcinoma

Sung, W. W., Wang, Y. C., Lin, P. L., Cheng, Y. W., Chen, C. Y., Wu, T. C. & Lee, H., Aug 1 2013, In : Clinical Cancer Research. 19, 15, p. 4092-4103 12 p.

Research output: Contribution to journalArticle

Interleukin-10
Up-Regulation
Neoplasms
1-Phosphatidylinositol 4-Kinase
Messenger RNA
Antigens
Nanofibers
Antibodies
Grafts
Semiconductor quantum dots

Immune effector monocyte–neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer

Hagerling, C., Gonzalez, H., Salari, K., Wang, C. Y., Lin, C., Robles, I., van Gogh, M., Dejmek, A., Jirström, K. & Werb, Z., Oct 22 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 43, p. 21704-21714 11 p.

Research output: Contribution to journalArticle

Open Access
Monocytes
Neutrophils
Breast Neoplasms
Neoplasms
Lung
7 Citations (Scopus)

Important Roles of Ring Finger Protein 112 in Embryonic Vascular Development and Brain Functions

Tsou, J. H., Yang, Y. C., Pao, P. C., Lin, H. C., Huang, N. K., Lin, S. T., Hsu, K. S., Yeh, C. M., Lee, K. H., Kuo, C. J., Yang, D. M., Lin, J. H., Chang, W. C. & Lee, Y. C., 2017, In : Molecular Neurobiology. p. 1-15 15 p.

Research output: Contribution to journalArticle

Fingers
Embryonic Development
Blood Vessels
Brain
Proteins
2 Citations (Scopus)

Incomplete success of angioinhibitor therapy in cancer: Estimation of contribution of pro-angiogenic activity of patient thyroid hormone

Davis, P. J., Yalcin, M., Lin, H. Y., Tang, H. Y., Hercbergs, A., Leith, J. T., Davis, F. B., Luidens, M. K. & Mousa, S. A., 2013, In : Journal of Cancer Science and Therapy. 5, 12, p. 441-445 5 p.

Research output: Contribution to journalArticle

Thyroid Hormones
Heterografts
Neoplasms
Therapeutics
Chorioallantoic Membrane
15 Citations (Scopus)

Increased levels of circulating advanced glycation end-products in menopausal women with osteoporosis

Yang, D. H., Chiang, T. I., Chang, I. C., Lin, F. H., Wei, C. C. & Cheng, Y. W., 2014, In : International Journal of Medical Sciences. 11, 4, p. 453-460 8 p.

Research output: Contribution to journalArticle

Advanced Glycosylation End Products
Osteoporosis
Metabolic Bone Diseases
Serum
Bone and Bones
3 Citations (Scopus)

Indole-3-ethylsulfamoylphenylacrylamides with potent anti-proliferative and anti-angiogenic activities

Mehndiratta, S., Pan, S. L., Kumar, S. & Liou, J. P., Jul 1 2016, In : Anti-Cancer Agents in Medicinal Chemistry. 16, 7, p. 907-913 7 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Acrylamide
Acrylamides
Neoplasms
Nude Mice
7 Citations (Scopus)

Influences of core morphology on electrocapacitive performance of NiCo2O4-based core/shell electrodes

Lin, L-Y., Lin, H-Y., Hong, W-L. & Lin, L-Y., 2018, In : Thin Solid Films. 667, p. 69-75 7 p.

Research output: Contribution to journalArticle

Nanowires
Nanosheets
Nickel
Energy storage
Electrodes
10 Citations (Scopus)

Inhibition of the androgen receptor induces a novel tumor promoter, ZBTB46, for prostate cancer metastasis

Chen, W-Y., Tsai, Y-C., Siu, M. K., Yeh, H-L., Chen, C-L., Yin, J. J., Huang, J. & Liu, Y-N., Jul 10 2017, In : Oncogene. p. 6213-6224

Research output: Contribution to journalArticle

Androgen Receptors
Carcinogens
Prostatic Neoplasms
Neoplasm Metastasis
Epithelial-Mesenchymal Transition
7 Citations (Scopus)

Inhibitory effect of Anoectochilus formosanus extract on hyperglycemia-related PD-L1 expression and cancer proliferation

Ho, Y., Chen, Y. F., Wang, L. H., Hsu, K. Y., Chin, Y. T., Yang, Y. C. S. H., Wang, S. H., Chen, Y. R., Shih, Y. J., Liu, L. F., Wang, K., Whang-Peng, J., Tang, H. Y., Lin, H. Y., Liu, H. L. & Lin, S. J., Aug 2 2018, In : Frontiers in Pharmacology. 9, AUG, 807.

Research output: Contribution to journalArticle

Obese Mice
Hyperglycemia
Blood Glucose
Metformin
Hypoglycemic Agents
9 Citations (Scopus)
Metallothionein
Computer Simulation
Hepatocellular Carcinoma
Genes
Therapeutics
2 Citations (Scopus)

In silico and in vitro identification of inhibitory activities of sorafenib on histone deacetylases in hepatocellular carcinoma cells

Liu, T. P., Hong, Y. H. & Yang, P. M., Oct 17 2017, In : Oncotarget. 8, 49, p. 86168-86180 13 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Computer Simulation
Hepatocellular Carcinoma
Polypharmacology
Histone Deacetylase Inhibitors
Pituitary Neoplasms
Oncogenes
Renal Cell Carcinoma
Computer Simulation
Neoplasms
Open Access
gemcitabine
Computational Biology
Cell Cycle
Adenocarcinoma
Therapeutics

Integrin-Mediated Actions of Thyroid Hormone Analogues on Tumor Cell Chemosensitivity, Integrin-Growth Factor Receptor Crosstalk and Inflammatory Gene Expression.

Hercbergs, A., Davis, F. B., Lin, H-Y., Luidens, M. K., Meng, R., Ashur-Fabian, O., Mousa, S. A. & Davis, P. J., 2012, In : Cancer and Clinical Oncology . 1, p. 32-40 9 p.

Research output: Contribution to journalArticle

Growth Factor Receptors
Thyroid Hormones
Integrins
Gene Expression
Neoplasms
10 Citations (Scopus)

Integrin β3 and LKB1 are independently involved in the inhibition of proliferation by lovastatin in human intrahepatic cholangiocarcinoma

Yang, S. H., Lin, H. Y., Changou, C. A., Chen, C. H., Liu, Y. R., Wang, J., Jiang, X., Luh, F. & Yen, Y., Jan 1 2016, In : Oncotarget. 7, 1, p. 362-373 12 p.

Research output: Contribution to journalArticle

Lovastatin
Cholangiocarcinoma
Integrins
Cell Adhesion
Intercellular Adhesion Molecule-1

Interaction of S17 antibody with the functional binding region of the hepatitis B virus pre-S2 epitope

Chang, C. Y., Chang, F. L., Chiang, C. W., Lo, Y. N., Lin, T. Y., Chen, W. C., Tsai, K. C. & Lee, Y. C., Sep 1 2018, In : Viral Immunology. 31, 7, p. 492-499 8 p.

Research output: Contribution to journalArticle

Hepatitis B virus
Epitopes
Single-Chain Antibodies
Virus Diseases
Surface Antigens