Ph.D. Program for Cancer Molecular Biology and Drug Discovery

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output 1996 2020

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2 Citations (Scopus)

1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma

Liu, Y. M., HuangFu, W. C., Huang, H. L., Wu, W. C., Chen, Y. L., Yen, Y., Huang, H. L., Nien, C. Y., Lai, M. J., Pan, S. L. & Liou, J. P., Nov 10 2017, In : European Journal of Medicinal Chemistry. 140, p. 84-91 8 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Multiple Myeloma
Tumors
Lead compounds
Growth
8 Citations (Scopus)

1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC

Ojha, R., Huang, H. L., HuangFu, W. C., Wu, Y. W., Nepali, K., Lai, M. J., Su, C. J., Sung, T. Y., Chen, Y. L., Pan, S. L. & Liou, J. P., Apr 25 2018, In : European Journal of Medicinal Chemistry. 150, p. 667-677 11 p.

Research output: Contribution to journalArticle

Hydroxamic Acids
Histone Deacetylase Inhibitors
Antineoplastic Agents
Protein Isoforms
Cells
13 Citations (Scopus)
Histone Deacetylase Inhibitors
Tumors
Prostatic Neoplasms
Cells
Lead compounds
5 Citations (Scopus)

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

Benzamides
Histone Deacetylases
Tubulin
Heterografts
Inhibitory Concentration 50
12 Citations (Scopus)

2,3,5,4′-tetrahydroxystilbene-2-O- β -glucoside isolated from Polygoni Multiflori ameliorates the development of periodontitis

Chin, Y. T., Hsieh, M. T., Lin, C. Y., Kuo, P. J., Yang, Y. C. S. H., Shih, Y. J., Lai, H. Y., Cheng, G. Y., Tang, H. Y., Lee, C. C., Lee, S. Y., Wang, C. C., Lin, H. Y., Fu, E., Whang-Peng, J. & Liu, L. F., 2016, In : Mediators of Inflammation. 2016, 6953459.

Research output: Contribution to journalArticle

Porphyromonas gingivalis
Periodontitis
Ligation
Lipopolysaccharides
AMP-Activated Protein Kinases
2 Citations (Scopus)

2,3,5,4′-Tetrahydroxystilbene-2-O-β-glucoside potentiates self-renewal of human dental pulp stem cells via the AMPK/ERK/SIRT1 axis

Lin, C. Y., Chin, Y. T., Kuo, P. J., Lee, H. W., Huang, H. M., Lin, H. Y., Weng, I. T., Hsiung, C. N., Chan, Y. H. & Lee, S. Y., Oct 1 2018, In : International Endodontic Journal. 51, 10, p. 1159-1170 12 p.

Research output: Contribution to journalArticle

Sirtuin 1
Dental Pulp
AMP-Activated Protein Kinases
Mitogen-Activated Protein Kinase 3
Stem Cells
9 Citations (Scopus)

3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity

Lee, H-Y., Lee, J. F., Kumar, S., Wu, Y. W., HuangFu, W-C., Lai, M-J., Li, Y-H., Huang, H. L., Kuo, F. C., Hsiao, C. J., Cheng, C. C., Yang, C. R. & Liou, J-P., Jan 5 2017, In : European Journal of Medicinal Chemistry. 125, p. 1268-1278 11 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Tubulin
Bioactivity
Hydroxamic Acids
Tubulin Modulators
1 Citation (Scopus)

4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy

Lin, S. Y., Yeh, T. K., Song, J. S., Hung, M. S., Cheng, M. F., Liao, F. Y., Li, A. S., Cheng, S. Y., Lin, L. M., Chiu, C. H., Wu, M. H., Lin, Y. J., Hsiao, W., Sun, M., Wang, Y. H., Huang, C. H., Tang, Y. C., Chang, H. H., Huang, Z. T., Chao, Y. S. & 5 others, Shih, C., Pan, S. L., Wu, S. Y., Kuo, C. C. & Ueng, S. H., Apr 1 2018, In : Bioorganic Chemistry. 77, p. 600-607 8 p.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Tumors
Neoplasms
T-cells
Pharmaceutical Preparations
8 Citations (Scopus)

4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors in vitro and in vivo

Mehndiratta, S., Wang, R. S., Huang, H. L., Su, C. J., Hsu, C. M., Wu, Y. W., Pan, S. L. & Liou, J. P., Jul 7 2017, In : European Journal of Medicinal Chemistry. 134, p. 13-23 11 p.

Research output: Contribution to journalArticle

Heterografts
Tumors
Bearings (structural)
Histone Deacetylase Inhibitors
Acrylamide
12 Citations (Scopus)

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes

Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Jan 29 2018, (Accepted/In press) In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

tau Proteins
Histone Deacetylase Inhibitors
Alzheimer Disease
Hydroxamic Acids
Phenotype
6 Citations (Scopus)

A combination of anti-PD-L1 mAb plus Lm-LLO-E6 vaccine efficiently suppresses tumor growth and metastasis in HPV-infected cancers

Lin, P. L., Cheng, Y. M., Wu, D. W., Huang, Y. J., Lin, H. C., Chen, C. Y. & Lee, H., 2017, (Accepted/In press) In : Cancer Medicine.

Research output: Contribution to journalArticle

Vaccines
Neoplasm Metastasis
Growth
Neoplasms
Nude Mice
1 Citation (Scopus)

Action of Reverse T3 on Cancer Cells

Lin, H. Y., Tang, H. Y., Leinung, M., Mousa, S. A., Hercbergs, A. & Davis, P. J., Jan 1 2019, In : Endocrine Research.

Research output: Contribution to journalArticle

Integrins
Thyronines
Thyroid Hormone Receptors
Neoplasms
Glioblastoma
30 Citations (Scopus)

Actions of l-thyroxine and Nano-diamino-tetrac (Nanotetrac) on PD-L1 in cancer cells

Lin, H. Y., Chin, Y-T., Nana, A. W., Shih, Y-J., Lai, H-Y., Tang, H-Y., Leinung, M., Mousa, S. A. & Davis, P. J., Jan 28 2016, (Accepted/In press) In : Steroids.

Research output: Contribution to journalArticle

Thyroxine
Cells
Gene expression
Neoplasms
Proteins
31 Citations (Scopus)

Activated PAR-2 regulates pancreatic cancer progression through ILK/HIF-α-induced TGF-α expression and MEK/VEGF-a-mediated angiogenesis

Chang, L. H., Pan, S. L., Lai, C. Y., Tsai, A. C. & Teng, C. M., Aug 2013, In : American Journal of Pathology. 183, 2, p. 566-575 10 p.

Research output: Contribution to journalArticle

PAR-2 Receptor
Mitogen-Activated Protein Kinase Kinases
Transforming Growth Factors
Pancreatic Neoplasms
Vascular Endothelial Growth Factor A
16 Citations (Scopus)

Activation of a novel ubiquitin-independent proteasome pathway when RNA polymerase II encounters a protein roadblock

Ban, Y., Ho, C. W., Lin, R. K., Lyu, Y. L. & Liu, L-F., 2013, In : Molecular and Cellular Biology. 33, 20, p. 4008-4016 9 p.

Research output: Contribution to journalArticle

RNA Polymerase II
Proteasome Endopeptidase Complex
Ubiquitin
Adenosine Triphosphatases
Type II DNA Topoisomerase
23 Citations (Scopus)

Activation of NF-κB by SOD2 promotes the aggressiveness of lung adenocarcinoma by modulating NKX2-1-mediated IKKβ expression

Chen, P. M., Wu, T. C., Wang, Y. C., Cheng, Y. W., Sheu, G. T., Chen, C. Y. & Lee, H., Nov 2013, In : Carcinogenesis. 34, 11, p. 2655-2663 9 p.

Research output: Contribution to journalArticle

Messenger RNA
Neoplasms
Lung
Epithelial-Mesenchymal Transition
Survival
9 Citations (Scopus)

ADAM9 enhances CDCP1 by inhibiting miR-1 through EGFR signaling activation in lung cancer metastasis

Chiu, K. L., Lin, Y. S., Kuo, T. T., Lo, C. C., Huang, Y. K., Chang, H. F., Chuang, E. Y., Lin, C. C., Cheng, W. C., Liu, Y. N., Lai, L. C. & Sher, Y. P., 2017, In : Oncotarget. 8, 29, p. 47365-47378 14 p.

Research output: Contribution to journalArticle

Disintegrins
Metalloproteases
Lung Neoplasms
Neoplasm Metastasis
MicroRNAs
13 Citations (Scopus)

A dominant antigenic epitope on SARS-CoV spike protein identified by an avian single-chain variable fragment (scFv)-expressing phage

Lee, Y. C., Leu, S. J. C., Hung, H. C., Wu, H. H., Huang, I. J., Hsieh, W. S., Chiu, W. T., Hsieh, M. S., Cheng, T. F. & Yang, Y. Y., May 15 2007, In : Veterinary Immunology and Immunopathology. 117, 1-2, p. 75-85 11 p.

Research output: Contribution to journalArticle

Avian Proteins
Severe Acute Respiratory Syndrome
Single-Chain Antibodies
bacteriophages
Bacteriophages
1 Citation (Scopus)

Age, but not short-term intensive swimming, affects chondrocyte turnover in zebrafish vertebral cartilage

Jian, Q. L., HuangFu, W. C., Lee, Y. H. & Liu, I. H., Jan 1 2018, In : PeerJ. 2018, 10, e5739.

Research output: Contribution to journalArticle

chondrocytes
Cartilage
Zebrafish
Chondrocytes
Danio rerio
27 Citations (Scopus)

A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine

Lee, K. H., Lo, H. L., Tang, W. C., Hsiao, H. H. Y. & Yang, P. M., 2014, In : Scientific Reports. 4, 6394.

Research output: Contribution to journalArticle

Berberine
Herbal Medicine
Transcriptome
Histone Deacetylases
Sirolimus
12 Citations (Scopus)

A germline missense mutation in COQ6 is associated with susceptibility to familial schwannomatosis

Zhang, K., Lin, J. W., Wang, J., Wu, X., Gao, H., Hsieh, Y. C., Hwu, P., Liu, Y. R., Su, L., Chiou, H. Y., Wang, D., Yuan, Y. C., Whang-Peng, J., Chiu, W. T. & Yen, Y., Oct 1 2014, In : Genetics in Medicine. 16, 10, p. 787-792 6 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Missense Mutation
coenzyme Q10
Genome
Exome

A homozygous variant in RRM2B is associated with severe metabolic acidosis and early neonatal death

Penque, B. A., Su, L., Wang, J., Ji, W., Bale, A., Luh, F., Fulbright, R. K., Sarmast, U., Sega, A. G., Konstantino, M., Spencer-Manzon, M., Pierce, R., Yen, Y. & Lakhani, S. A., Jan 1 2018, (Accepted/In press) In : European Journal of Medical Genetics.

Research output: Contribution to journalArticle

Acidosis
Mutation
Ribonucleotide Reductases
Failure to Thrive
Lactic Acidosis
67 Citations (Scopus)

A KRAS mutation status-stratified randomized phase II trial of gemcitabine and oxaliplatin alone or in combination with cetuximab in advanced biliary tract cancer

Chen, J. S., Hsu, C., Chiang, N. J., Tsai, C. S., Tsou, H. H., Huang, S. F., Bai, L. Y., Chang, I. C., Shiah, H. S., Ho, C. L., Yen, C. J., Lee, K. D., Chiu, C. F., Rau, K. M., Yu, M. S., Yang, Y., Hsieh, R. K., Chang, J. Y., Shan, Y. S., Chao, Y. & 13 others, Chen, L. T., Chin, Y. H., Chung, T. R., Yu, W. L., Lee, M. H., Lin, L. F., Lin, P. C., Wu, Y. L., Wang, H. L., Lu, L. J., Chen, S. Y., Wu, C. C. & Wei, T. C., May 1 2015, In : Annals of Oncology. 26, 5, p. 943-949 7 p., mdv035.

Research output: Contribution to journalArticle

oxaliplatin
gemcitabine
Biliary Tract Neoplasms
Mutation
Exanthema
8 Citations (Scopus)

A low microRNA-630 expression confers resistance to tyrosine kinase inhibitors in EGFR-mutated lung adenocarcinomas via miR-630/YAP1/ERK feedback loop

Wu, D. W., Wang, Y. C., Wang, L., Chen, C. Y. & Lee, H., Jan 1 2018, In : Theranostics. 8, 5, p. 1256-1269 14 p.

Research output: Contribution to journalArticle

MicroRNAs
Protein-Tyrosine Kinases
bcl-Associated Death Protein
Neoplasms
Adenocarcinoma of lung
9 Citations (Scopus)

Alpha 7-nicotinic acetylcholine receptor mediates the sensitivity of gastric cancer cells to 5-fluorouracil

Chen, W-Y., Huang, C. Y., Cheng, W. L., Hung, C-S., Huang, M-T., Tai, C-J., Liu, Y-N., Chen, C-L. & Chang, Y-J., Jul 3 2015, (Accepted/In press) In : Tumor Biology. 36, 12, p. 9537-9544

Research output: Contribution to journalArticle

Nicotinic Receptors
Fluorouracil
Stomach Neoplasms
In Situ Nick-End Labeling
Cell Cycle

Alternative splicing in human cancer cells is modulated by the amiloride derivative 3,5-diamino-6-chloro-N-(N-(2,6-dichlorobenzoyl)carbamimidoyl)pyrazine-2-carboxide

Lee, C. C., Chang, W. H., Chang, Y. S., Yang, J. M., Chang, C. S., Hsu, K. C., Chen, Y. T., Liu, T. Y., Chen, Y. C., Lin, S. Y., Wu, Y. C. & Chang, J. G., Jan 1 2019, In : Molecular Oncology. 13, 8, p. 1744-1762 19 p.

Research output: Contribution to journalArticle

Open Access
Pyrazines
Amiloride
Alternative Splicing
Neoplasms
RNA Sequence Analysis
39 Citations (Scopus)

A lytic viral long noncoding RNA modulates the function of a latent protein

Campbell, M., Kim, K. Y., Chang, P. C., Huerta, S., Shevchenko, B., Wang, D. H., Izumiya, C., Kung, H. J. & Izumiya, Y., Feb 1 2014, In : Journal of Virology. 88, 3, p. 1843-1848 6 p.

Research output: Contribution to journalArticle

nuclear antigens
Long Noncoding RNA
Human herpesvirus 8
Human Herpesvirus 8
plasmids
5 Citations (Scopus)

Amentoflavone inhibits hepatocellular carcinoma progression through blockage of ERK/NF-κB activation

Lee, K. C., Chen, W. T., Liu, Y. C., Lin, S. S. & Hsu, F. T., Sep 1 2018, In : In Vivo. 32, 5, p. 1097-1103 7 p.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
Hepatocellular Carcinoma
Chemical activation
Tumors
Liver
Growth Inhibitors
Amides
Prostatic Neoplasms
Cells
Lead compounds
93 Citations (Scopus)

AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis

Chou, C. C., Lee, K. H., Lai, I. L., Wang, D., Mo, X., Kulp, S. K., Shapiro, C. L. & Chen, C. S., Sep 1 2014, In : Cancer Research. 74, 17, p. 4783-4795 13 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Epithelial-Mesenchymal Transition
Phenotype
Neoplasms
Ubiquitin-Protein Ligases
49 Citations (Scopus)

Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway in high-grade liposarcoma

Zhang, K., Chu, K., Wu, X., Gao, H., Wang, J., Yuan, Y. C., Loera, S., Ho, K., Wang, Y., Chow, W., Un, F., Chu, P. & Yen, Y., Jan 15 2013, In : Cancer Research. 73, 4, p. 1298-1307 10 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors
Liposarcoma
Sarcoma
Proteins
Receptor, Fibroblast Growth Factor, Type 2
10 Citations (Scopus)

An apoptosis-related gene network induced by novel compound-cRGD in human breast cancer cells

Huang, T. C., Huang, H. C., Chang, C. C., Chang, H. Y., Ou, C. H., Hsu, C. H., Chen, S. T. & Juan, H. F., Jul 24 2007, In : FEBS Letters. 581, 18, p. 3517-3522 6 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Genes
Cells
Cell death
Apoptosis
3 Citations (Scopus)

Androgen deprivation-induced ZBTB46-PTGS1 signaling promotes neuroendocrine differentiation of prostate cancer

Chen, W. Y., Zeng, T., Wen, Y. C., Yeh, H. L., Jiang, K. C., Chen, W. H., Zhang, Q., Huang, J. & Liu, Y. N., Jan 1 2019, In : Cancer Letters. 440-441, p. 35-46 12 p.

Research output: Contribution to journalArticle

Prostaglandin-Endoperoxide Synthases
Androgens
Prostatic Neoplasms
Cyclooxygenase Inhibitors
Androgen Receptors
4 Citations (Scopus)
Activating Transcription Factors
CC Chemokines
Epithelial-Mesenchymal Transition
Androgens
Prostatic Neoplasms
6 Citations (Scopus)

Androgen receptor regulates SRC expression through microRNA-203

Siu, M. K., Chen, W. Y., Tsai, H. Y., Yeh, H. L., Yin, J. J., Liu, S. Y. & Liu, Y-N., May 1 2016, In : Oncotarget. 7, 18, p. 25726-25741 16 p.

Research output: Contribution to journalArticle

Androgen Receptors
MicroRNAs
Prostatic Neoplasms
RNA Stability
3' Untranslated Regions
4 Citations (Scopus)

A new application of parallel synthesis strategy for discovery of amide-linked small molecules as potent chondroprotective agents in TNF-α-stimulated chondrocytes

Lee, C. C., Lo, Y., Ho, L. J., Lai, J. H., Lien, S. B., Lin, L. C., Chen, C. L., Chen, T. C., Liu, F. C. & Huang, H. S., Mar 1 2016, In : PLoS One. 11, 3, e0149317.

Research output: Contribution to journalArticle

chondrocytes
Nitric Oxide Synthase Type II
Chondrocytes
amides
Amides

A new niclosamide derivatives-B17 can inhibit urological cancers growth through apoptosis-related pathway

Wu, C-L., Chen, C-L., Huang, H-S. & Yu, D-S., Jun 28 2018, In : Cancer Medicine.

Research output: Contribution to journalArticle

Niclosamide
Urologic Neoplasms
Apoptosis
Growth
Control Groups
3 Citations (Scopus)

An improved ChIP-seq peak detection system for simultaneously identifying post-translational modified transcription factors by combinatorial fusion, using SUMOylation as an example

Cheng, C. Y., Chu, C. H., Hsu, H. W., Hsu, F. R., Tang, C. Y., Wang, W. C., Kung, H. J. & Chang, P. C., Jan 24 2014, In : BMC Genomics. 15, p. 1-14 14 p.

Research output: Contribution to journalArticle

Sumoylation
Chromatin Immunoprecipitation
Transcription Factors
Binding Sites
Post Translational Protein Processing
8 Citations (Scopus)

An increase in BAG-1 by PD-L1 confers resistance to tyrosine kinase inhibitor in non–small cell lung cancer via persistent activation of ERK signalling

Lin, P. L., Wu, T. C., Wu, D. W., Wang, L., Chen, C. Y. & Lee, H., Nov 1 2017, In : European Journal of Cancer. 85, p. 95-105 11 p.

Research output: Contribution to journalArticle

CD274 Antigen
Extracellular Signal-Regulated MAP Kinases
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Neoplasms
3 Citations (Scopus)

An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells

Chao, M. W., Huang, H. L., HuangFu, W. C., Hsu, K. C., Liu, Y. M., Wu, Y. W., Lin, C. F., Chen, Y. L., Lai, M. J., Lee, H. Y., Liou, J. P., Teng, C. M. & Yang, C. R., 2017, In : Oncotarget. 8, 17, p. 27772-27785 14 p.

Research output: Contribution to journalArticle

Leukemia
Pharmaceutical Preparations
Neoplasms
Glycoproteins
National Cancer Institute (U.S.)
7 Citations (Scopus)

A novel action mechanism for MPT0g013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through upregulation of TIMP3 expression

Wang, C-Y., Liou, J. P., Tsai, A-C., Lai, M-J., Liu, Y-M., Lee, H. Y., Wang, J-C., Pan, S. L. & Teng, C-M., 2014, In : Oncotarget. 5, 20, p. 9838-9850 13 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-3
Up-Regulation
Neoplasms
Cell Cycle Resting Phase
Proteins
22 Citations (Scopus)

A novel class I HDAC inhibitor, MPT0G030, induces cell apoptosis and differentiation in human colorectal cancer cells via HDAC1/PKCδ and E-cadherin

Wang, L. T., Liou, J. P., Li, Y. H., Liu, Y. M., Pan, S. L. & Teng, C. M., 2014, In : Oncotarget. 5, 14, p. 5651-5662 12 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Cadherins
Protein Kinase C
Cell Differentiation
Colorectal Neoplasms
4 Citations (Scopus)

A novel compound NSC745885 exerts an anti-tumor effect on tongue cancer SAS cells in vitro and in vivo

Chen, Y. W., Huang, H. S., Shieh, Y. S., Ma, K. H., Huang, S. H., Hueng, D. Y., Sytwu, H. K. & Lin, G. J., Aug 15 2014, In : PLoS One. 9, 8, e104703.

Research output: Contribution to journalArticle

Tongue Neoplasms
tongue
Doxorubicin
Tumors
Anthracyclines
3 Citations (Scopus)

A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo

Wu, Y. W., Hsu, K. C., Lee, H. Y., Huang, T. C., Lin, T. E., Chen, Y. L., Sung, T. Y., Liou, J. P., Hwang-Verslues, W. W., Pan, S. L. & HuangFu, W. C., Mar 13 2018, In : Frontiers in Pharmacology. 9, MAR, 205.

Research output: Contribution to journalArticle

Tubulin Modulators
Histone Deacetylases
Neoplasms
Tubulin
Molecular Docking Simulation
Open Access
temozolomide
Glioblastoma
Phenotype
Glioma
Stem Cells

A Novel Selective JAK2 Inhibitor Identified Using Pharmacological Interactions

Lin, T. E., HuangFu, W-C., Chao, M-W., Sung, T-Y., Chang, C-D., Chen, Y-Y., Hsieh, J-H., Tu, H-J., Huang, H-L., Pan, S-L. & Hsu, K-C., 2018, In : Frontiers in Pharmacology. 9, p. 1379

Research output: Contribution to journalArticle

Janus Kinases
Phosphotransferases
Binding Sites
Pharmacology
Cytokine Receptors
17 Citations (Scopus)
Histone Deacetylases
Human Activities
Refractory materials
Prostatic Neoplasms
Display devices
25 Citations (Scopus)

Anticancer activity of MPT0E028, a novel potent histone deacetylase inhibitor, in human colorectal cancer HCT116 cells in vitro and in vivo

Huang, H-L., Lee, H. Y., Tsai, A-C., Peng, C-Y., Lai, M-J., Wang, J-C., Pan, S. L., Teng, C-M. & Liou, J. P., Aug 22 2012, In : PLoS One. 7, 8, e43645.

Research output: Contribution to journalArticle

HCT116 Cells
histone deacetylase
Histone Deacetylase Inhibitors
colorectal neoplasms
Colorectal Neoplasms
2 Citations (Scopus)

Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo

Huangfu, W. C., Chao, M. W., Cheng, C. C., Wei, Y. C., Wu, Y. W., Liou, J. P., Hsiao, G., Lee, Y. C. & Yang, C. R., Feb 9 2017, In : Scientific Reports. 7, 42291.

Research output: Contribution to journalArticle

Tubulin
Leukemia
Apoptosis
Caspase 7
Drug Therapy