Ph.D. Program for Cancer Molecular Biology and Drug Discovery

  • No. 250 Wu-Xing Street

    11031 Taipei

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1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma

Liu, Y. M., HuangFu, W. C., Huang, H. L., Wu, W. C., Chen, Y. L., Yen, Y., Huang, H. L., Nien, C. Y., Lai, M. J., Pan, S. L. & Liou, J. P., Nov 10 2017, In : European Journal of Medicinal Chemistry. 140, p. 84-91 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC

Ojha, R., Huang, H. L., HuangFu, W. C., Wu, Y. W., Nepali, K., Lai, M. J., Su, C. J., Sung, T. Y., Chen, Y. L., Pan, S. L. & Liou, J. P., Apr 25 2018, In : European Journal of Medicinal Chemistry. 150, p. 667-677 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
16 Citations (Scopus)

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

2,3,5,4′-tetrahydroxystilbene-2-O- β -glucoside isolated from Polygoni Multiflori ameliorates the development of periodontitis

Chin, Y. T., Hsieh, M. T., Lin, C. Y., Kuo, P. J., Yang, Y. C. S. H., Shih, Y. J., Lai, H. Y., Cheng, G. Y., Tang, H. Y., Lee, C. C., Lee, S. Y., Wang, C. C., Lin, H. Y., Fu, E., Whang-Peng, J. & Liu, L. F., 2016, In : Mediators of Inflammation. 2016, 6953459.

Research output: Contribution to journalArticle

13 Citations (Scopus)

2,3,5,4′-Tetrahydroxystilbene-2-O-β-glucoside potentiates self-renewal of human dental pulp stem cells via the AMPK/ERK/SIRT1 axis

Lin, C. Y., Chin, Y. T., Kuo, P. J., Lee, H. W., Huang, H. M., Lin, H. Y., Weng, I. T., Hsiung, C. N., Chan, Y. H. & Lee, S. Y., Oct 1 2018, In : International Endodontic Journal. 51, 10, p. 1159-1170 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity

Lee, H-Y., Lee, J. F., Kumar, S., Wu, Y. W., HuangFu, W-C., Lai, M-J., Li, Y-H., Huang, H. L., Kuo, F. C., Hsiao, C. J., Cheng, C. C., Yang, C. R. & Liou, J-P., Jan 5 2017, In : European Journal of Medicinal Chemistry. 125, p. 1268-1278 11 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy

Lin, S. Y., Yeh, T. K., Song, J. S., Hung, M. S., Cheng, M. F., Liao, F. Y., Li, A. S., Cheng, S. Y., Lin, L. M., Chiu, C. H., Wu, M. H., Lin, Y. J., Hsiao, W., Sun, M., Wang, Y. H., Huang, C. H., Tang, Y. C., Chang, H. H., Huang, Z. T., Chao, Y. S. & 5 others, Shih, C., Pan, S. L., Wu, S. Y., Kuo, C. C. & Ueng, S. H., Apr 1 2018, In : Bioorganic Chemistry. 77, p. 600-607 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors in vitro and in vivo

Mehndiratta, S., Wang, R. S., Huang, H. L., Su, C. J., Hsu, C. M., Wu, Y. W., Pan, S. L. & Liou, J. P., Jul 7 2017, In : European Journal of Medicinal Chemistry. 134, p. 13-23 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes

Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Jan 29 2018, (Accepted/In press) In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

15 Citations (Scopus)

A combination of anti-PD-L1 mAb plus Lm-LLO-E6 vaccine efficiently suppresses tumor growth and metastasis in HPV-infected cancers

Lin, P. L., Cheng, Y. M., Wu, D. W., Huang, Y. J., Lin, H. C., Chen, C. Y. & Lee, H., 2017, (Accepted/In press) In : Cancer Medicine.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Action of Reverse T3 on Cancer Cells

Lin, H. Y., Tang, H. Y., Leinung, M., Mousa, S. A., Hercbergs, A. & Davis, P. J., Jan 1 2019, In : Endocrine Research.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Actions of l-thyroxine and Nano-diamino-tetrac (Nanotetrac) on PD-L1 in cancer cells

Lin, H. Y., Chin, Y-T., Nana, A. W., Shih, Y-J., Lai, H-Y., Tang, H-Y., Leinung, M., Mousa, S. A. & Davis, P. J., Jan 28 2016, (Accepted/In press) In : Steroids.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Activated PAR-2 regulates pancreatic cancer progression through ILK/HIF-α-induced TGF-α expression and MEK/VEGF-a-mediated angiogenesis

Chang, L. H., Pan, S. L., Lai, C. Y., Tsai, A. C. & Teng, C. M., Aug 2013, In : American Journal of Pathology. 183, 2, p. 566-575 10 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Activation of a novel ubiquitin-independent proteasome pathway when RNA polymerase II encounters a protein roadblock

Ban, Y., Ho, C. W., Lin, R. K., Lyu, Y. L. & Liu, L-F., 2013, In : Molecular and Cellular Biology. 33, 20, p. 4008-4016 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Activation of NF-κB by SOD2 promotes the aggressiveness of lung adenocarcinoma by modulating NKX2-1-mediated IKKβ expression

Chen, P. M., Wu, T. C., Wang, Y. C., Cheng, Y. W., Sheu, G. T., Chen, C. Y. & Lee, H., Nov 2013, In : Carcinogenesis. 34, 11, p. 2655-2663 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

ADAM9 enhances CDCP1 by inhibiting miR-1 through EGFR signaling activation in lung cancer metastasis

Chiu, K. L., Lin, Y. S., Kuo, T. T., Lo, C. C., Huang, Y. K., Chang, H. F., Chuang, E. Y., Lin, C. C., Cheng, W. C., Liu, Y. N., Lai, L. C. & Sher, Y. P., 2017, In : Oncotarget. 8, 29, p. 47365-47378 14 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

A dominant antigenic epitope on SARS-CoV spike protein identified by an avian single-chain variable fragment (scFv)-expressing phage

Lee, Y. C., Leu, S. J. C., Hung, H. C., Wu, H. H., Huang, I. J., Hsieh, W. S., Chiu, W. T., Hsieh, M. S., Cheng, T. F. & Yang, Y. Y., May 15 2007, In : Veterinary Immunology and Immunopathology. 117, 1-2, p. 75-85 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Age, but not short-term intensive swimming, affects chondrocyte turnover in zebrafish vertebral cartilage

Jian, Q. L., HuangFu, W. C., Lee, Y. H. & Liu, I. H., Jan 1 2018, In : PeerJ. 2018, 10, e5739.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine

Lee, K. H., Lo, H. L., Tang, W. C., Hsiao, H. H. Y. & Yang, P. M., 2014, In : Scientific Reports. 4, 6394.

Research output: Contribution to journalArticle

30 Citations (Scopus)

A germline missense mutation in COQ6 is associated with susceptibility to familial schwannomatosis

Zhang, K., Lin, J. W., Wang, J., Wu, X., Gao, H., Hsieh, Y. C., Hwu, P., Liu, Y. R., Su, L., Chiou, H. Y., Wang, D., Yuan, Y. C., Whang-Peng, J., Chiu, W. T. & Yen, Y., Oct 1 2014, In : Genetics in Medicine. 16, 10, p. 787-792 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

A homozygous variant in RRM2B is associated with severe metabolic acidosis and early neonatal death

Penque, B. A., Su, L., Wang, J., Ji, W., Bale, A., Luh, F., Fulbright, R. K., Sarmast, U., Sega, A. G., Konstantino, M., Spencer-Manzon, M., Pierce, R., Yen, Y. & Lakhani, S. A., Jan 1 2018, (Accepted/In press) In : European Journal of Medical Genetics.

Research output: Contribution to journalArticle

A KRAS mutation status-stratified randomized phase II trial of gemcitabine and oxaliplatin alone or in combination with cetuximab in advanced biliary tract cancer

Chen, J. S., Hsu, C., Chiang, N. J., Tsai, C. S., Tsou, H. H., Huang, S. F., Bai, L. Y., Chang, I. C., Shiah, H. S., Ho, C. L., Yen, C. J., Lee, K. D., Chiu, C. F., Rau, K. M., Yu, M. S., Yang, Y., Hsieh, R. K., Chang, J. Y., Shan, Y. S., Chao, Y. & 13 others, Chen, L. T., Chin, Y. H., Chung, T. R., Yu, W. L., Lee, M. H., Lin, L. F., Lin, P. C., Wu, Y. L., Wang, H. L., Lu, L. J., Chen, S. Y., Wu, C. C. & Wei, T. C., May 1 2015, In : Annals of Oncology. 26, 5, p. 943-949 7 p., mdv035.

Research output: Contribution to journalArticle

75 Citations (Scopus)

A low microRNA-630 expression confers resistance to tyrosine kinase inhibitors in EGFR-mutated lung adenocarcinomas via miR-630/YAP1/ERK feedback loop

Wu, D. W., Wang, Y. C., Wang, L., Chen, C. Y. & Lee, H., Jan 1 2018, In : Theranostics. 8, 5, p. 1256-1269 14 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Alpha 7-nicotinic acetylcholine receptor mediates the sensitivity of gastric cancer cells to 5-fluorouracil

Chen, W-Y., Huang, C. Y., Cheng, W. L., Hung, C-S., Huang, M-T., Tai, C-J., Liu, Y-N., Chen, C-L. & Chang, Y-J., Jul 3 2015, (Accepted/In press) In : Tumor Biology. 36, 12, p. 9537-9544

Research output: Contribution to journalArticle

12 Citations (Scopus)

Alternative splicing in human cancer cells is modulated by the amiloride derivative 3,5-diamino-6-chloro-N-(N-(2,6-dichlorobenzoyl)carbamimidoyl)pyrazine-2-carboxide

Lee, C. C., Chang, W. H., Chang, Y. S., Yang, J. M., Chang, C. S., Hsu, K. C., Chen, Y. T., Liu, T. Y., Chen, Y. C., Lin, S. Y., Wu, Y. C. & Chang, J. G., Jan 1 2019, In : Molecular Oncology. 13, 8, p. 1744-1762 19 p.

Research output: Contribution to journalArticle

Open Access

A lytic viral long noncoding RNA modulates the function of a latent protein

Campbell, M., Kim, K. Y., Chang, P. C., Huerta, S., Shevchenko, B., Wang, D. H., Izumiya, C., Kung, H. J. & Izumiya, Y., Feb 1 2014, In : Journal of Virology. 88, 3, p. 1843-1848 6 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Amentoflavone inhibits hepatocellular carcinoma progression through blockage of ERK/NF-κB activation

Lee, K. C., Chen, W. T., Liu, Y. C., Lin, S. S. & Hsu, F. T., Sep 1 2018, In : In Vivo. 32, 5, p. 1097-1103 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
1 Citation (Scopus)

AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis

Chou, C. C., Lee, K. H., Lai, I. L., Wang, D., Mo, X., Kulp, S. K., Shapiro, C. L. & Chen, C. S., Sep 1 2014, In : Cancer Research. 74, 17, p. 4783-4795 13 p.

Research output: Contribution to journalArticle

99 Citations (Scopus)

Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway in high-grade liposarcoma

Zhang, K., Chu, K., Wu, X., Gao, H., Wang, J., Yuan, Y. C., Loera, S., Ho, K., Wang, Y., Chow, W., Un, F., Chu, P. & Yen, Y., Jan 15 2013, In : Cancer Research. 73, 4, p. 1298-1307 10 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

An apoptosis-related gene network induced by novel compound-cRGD in human breast cancer cells

Huang, T. C., Huang, H. C., Chang, C. C., Chang, H. Y., Ou, C. H., Hsu, C. H., Chen, S. T. & Juan, H. F., Jul 24 2007, In : FEBS Letters. 581, 18, p. 3517-3522 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Androgen deprivation-induced ZBTB46-PTGS1 signaling promotes neuroendocrine differentiation of prostate cancer

Chen, W. Y., Zeng, T., Wen, Y. C., Yeh, H. L., Jiang, K. C., Chen, W. H., Zhang, Q., Huang, J. & Liu, Y. N., Jan 1 2019, In : Cancer Letters. 440-441, p. 35-46 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
9 Citations (Scopus)

Androgen receptor regulates SRC expression through microRNA-203

Siu, M. K., Chen, W. Y., Tsai, H. Y., Yeh, H. L., Yin, J. J., Liu, S. Y. & Liu, Y-N., May 1 2016, In : Oncotarget. 7, 18, p. 25726-25741 16 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

A new application of parallel synthesis strategy for discovery of amide-linked small molecules as potent chondroprotective agents in TNF-α-stimulated chondrocytes

Lee, C. C., Lo, Y., Ho, L. J., Lai, J. H., Lien, S. B., Lin, L. C., Chen, C. L., Chen, T. C., Liu, F. C. & Huang, H. S., Mar 1 2016, In : PLoS One. 11, 3, e0149317.

Research output: Contribution to journalArticle

5 Citations (Scopus)

A new niclosamide derivatives-B17 can inhibit urological cancers growth through apoptosis-related pathway

Wu, C-L., Chen, C-L., Huang, H-S. & Yu, D-S., Jun 28 2018, In : Cancer Medicine.

Research output: Contribution to journalArticle

1 Citation (Scopus)

An improved ChIP-seq peak detection system for simultaneously identifying post-translational modified transcription factors by combinatorial fusion, using SUMOylation as an example

Cheng, C. Y., Chu, C. H., Hsu, H. W., Hsu, F. R., Tang, C. Y., Wang, W. C., Kung, H. J. & Chang, P. C., Jan 24 2014, In : BMC Genomics. 15, p. 1-14 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

An increase in BAG-1 by PD-L1 confers resistance to tyrosine kinase inhibitor in non–small cell lung cancer via persistent activation of ERK signalling

Lin, P. L., Wu, T. C., Wu, D. W., Wang, L., Chen, C. Y. & Lee, H., Nov 1 2017, In : European Journal of Cancer. 85, p. 95-105 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
Open Access
2 Citations (Scopus)

An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells

Chao, M. W., Huang, H. L., HuangFu, W. C., Hsu, K. C., Liu, Y. M., Wu, Y. W., Lin, C. F., Chen, Y. L., Lai, M. J., Lee, H. Y., Liou, J. P., Teng, C. M. & Yang, C. R., 2017, In : Oncotarget. 8, 17, p. 27772-27785 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

A novel class I HDAC inhibitor, MPT0G030, induces cell apoptosis and differentiation in human colorectal cancer cells via HDAC1/PKCδ and E-cadherin

Wang, L. T., Liou, J. P., Li, Y. H., Liu, Y. M., Pan, S. L. & Teng, C. M., 2014, In : Oncotarget. 5, 14, p. 5651-5662 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

A novel compound NSC745885 exerts an anti-tumor effect on tongue cancer SAS cells in vitro and in vivo

Chen, Y. W., Huang, H. S., Shieh, Y. S., Ma, K. H., Huang, S. H., Hueng, D. Y., Sytwu, H. K. & Lin, G. J., Aug 15 2014, In : PLoS One. 9, 8, e104703.

Research output: Contribution to journalArticle

5 Citations (Scopus)

A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo

Wu, Y. W., Hsu, K. C., Lee, H. Y., Huang, T. C., Lin, T. E., Chen, Y. L., Sung, T. Y., Liou, J. P., Hwang-Verslues, W. W., Pan, S. L. & HuangFu, W. C., Mar 13 2018, In : Frontiers in Pharmacology. 9, MAR, 205.

Research output: Contribution to journalArticle

3 Citations (Scopus)
Open Access

A Novel Selective JAK2 Inhibitor Identified Using Pharmacological Interactions

Lin, T. E., HuangFu, W-C., Chao, M-W., Sung, T-Y., Chang, C-D., Chen, Y-Y., Hsieh, J-H., Tu, H-J., Huang, H-L., Pan, S-L. & Hsu, K-C., 2018, In : Frontiers in Pharmacology. 9, p. 1379

Research output: Contribution to journalArticle

18 Citations (Scopus)

Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo

Huangfu, W. C., Chao, M. W., Cheng, C. C., Wei, Y. C., Wu, Y. W., Liou, J. P., Hsiao, G., Lee, Y. C. & Yang, C. R., Feb 9 2017, In : Scientific Reports. 7, 42291.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivo

Hsieh, Y. L., Tu, H. J., Pan, S. L., Liou, J. P. & Yang, C. R., Jun 1 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 6, p. 992-1003 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)