Ph.D. Program for Cancer Molecular Biology and Drug Discovery

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output

Filter
Article
1996

The protective effect of alstonia scholaris r. br. on hepatotoxin-induced acute liver damage

Lin, S. C., Lin, C. C., Lin, Y. H., Supriyatna, S. & Pan, S. L., 1996, In : American Journal of Chinese Medicine. 24, 2, p. 153-164 12 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
2005
12 Citations (Scopus)
2007

A dominant antigenic epitope on SARS-CoV spike protein identified by an avian single-chain variable fragment (scFv)-expressing phage

Lee, Y. C., Leu, S. J. C., Hung, H. C., Wu, H. H., Huang, I. J., Hsieh, W. S., Chiu, W. T., Hsieh, M. S., Cheng, T. F. & Yang, Y. Y., May 15 2007, In : Veterinary Immunology and Immunopathology. 117, 1-2, p. 75-85 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

An apoptosis-related gene network induced by novel compound-cRGD in human breast cancer cells

Huang, T. C., Huang, H. C., Chang, C. C., Chang, H. Y., Ou, C. H., Hsu, C. H., Chen, S. T. & Juan, H. F., Jul 24 2007, In : FEBS Letters. 581, 18, p. 3517-3522 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Chicken single-chain variable fragments against the SARS-CoV spike protein

Lee, Y. C., Leu, S. J. C., Hu, C. J., Shih, N. Y., Huang, I. J., Wu, H. H., Hsieh, W. S., Chiang, B. L., Chiu, W. T. & Yang, Y. Y., Dec 2007, In : Journal of Virological Methods. 146, 1-2, p. 104-111 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Eosinophil apoptosis induced by fungal immunomodulatory peptide-fve via reducing IL-5α receptor

Hsieh, C. W., Lan, J. L., Meng, Q., Cheng, Y. W., Huang, H. M. & Tsai, J. J., Jan 2007, In : Journal of the Formosan Medical Association = Taiwan yi zhi. 106, 1, p. 36-43 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2008

Targeting therapy for breast carcinoma by ATP synthase inhibitor aurovertin b

Huang, T. C., Chang, H. Y., Hsu, C. H., Kuo, W. H., Chang, K. J. & Juan, H. F., Apr 2008, In : Journal of Proteome Research. 7, 4, p. 1433-1444 12 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)
2010

CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation

Tsai, A. C., Pan, S. L., Sun, H. L., Wang, C. Y., Peng, C. Y., Wang, S. W., Chang, Y. L., Kuo, S. C., Lee, K. H. & Teng, C. M., Feb 19 2010, In : Journal of Biological Chemistry. 285, 8, p. 5497-5506 10 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo

Tsai, A. C., Pan, S. L., Liao, C. H., Guh, J. H., Wang, S. W., Sun, H. L., Liu, Y. N., Chen, C. C., Shen, C. C., Chang, Y. L. & Teng, C. M., Jun 2010, In : Cancer Letters. 292, 2, p. 163-170 8 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

The indazole derivative YD-3 specifically inhibits thrombin-induced angiogenesis in vitro and in vivo

Peng, C. Y., Pan, S. L., Pai, H. C., Tsai, A. C., Guh, J. H., Chang, Y. L., Kuo, S. C., Lee, F. Y. & Teng, C. M., Dec 2010, In : Shock. 34, 6, p. 580-585 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2011

Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR

Huang, T. C., Chang, H. Y., Chen, C. Y., Wu, P. Y., Lee, H., Liao, Y. F., Hsu, W. M., Huang, H. C. & Juan, H. F., Nov 16 2011, In : FEBS Letters. 585, 22, p. 3582-3586 5 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

The effect of narrow bandwidth infrared radiation on the growth of Escherichia coli

Tsai, S. R., Huang, T. C., Liang, C. M., Chang, H. Y., Chang, Y. T., Huang, H. C., Juan, H. F. & Lee, S. C., Oct 17 2011, In : Applied Physics Letters. 99, 16, 163704.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The inhibition of angiogenesis and tumor growth by denbinobin is associated with the blocking of insulin-like growth factor-1 receptor signaling

Tsai, A. C., Pan, S. L., Lai, C. Y., Wang, C. Y., Chen, C. C., Shen, C. C. & Teng, C. M., Jul 2011, In : Journal of Nutritional Biochemistry. 22, 7, p. 625-633 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Thrombin induces expression of twist and cell motility via the hypoxia-inducible factor-1α translational pathway in colorectal cancer cells

Chang, L. H., Chen, C-H., Huang, D. Y., Pai, H. C., Pan, S. L. & Teng, C. M., Apr 2011, In : Journal of Cellular Physiology. 226, 4, p. 1060-1068 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2012

Anticancer activity of MPT0E028, a novel potent histone deacetylase inhibitor, in human colorectal cancer HCT116 cells in vitro and in vivo

Huang, H-L., Lee, H. Y., Tsai, A-C., Peng, C-Y., Lai, M-J., Wang, J-C., Pan, S. L., Teng, C-M. & Liou, J. P., Aug 22 2012, In : PLoS One. 7, 8, e43645.

Research output: Contribution to journalArticle

27 Citations (Scopus)

CYP1A1 protein activity is associated with allelic variation in pterygium tissues and cells

Peng, M. L., Tsai, Y. Y., Chiang, C. C., Huang, Y. C., Chou, M. C., Yeh, K. T., Lee, H. & Cheng, Y. W., 2012, In : Molecular Vision. 18, p. 1937-1943 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Differential Impact of IL-10 Expression on Survival and Relapse between HPV16-Positive and -Negative Oral Squamous Cell Carcinomas

Chuang, C. Y., Sung, W. W., Wang, L., Lin, W. L., Yeh, K. T., Su, M. C., Hsin, C. H., Lee, S. Y., Wu, B. C., Cheng, Y. W. & Lee, H., Oct 31 2012, In : PLoS One. 7, 10, e47541.

Research output: Contribution to journalArticle

19 Citations (Scopus)

DYZ-2-90, a Novel Neo-tanshinlactone Ring-Opened Compound, Induces ERK-Mediated Mitotic Arrest and Subsequent Apoptosis by Activating JNK in Human Colorectal Cancer Cells

Wang, L. T., Pan, S. L., Chen, T. H., Dong, Y., Lee, K. H. & Teng, C. M., Jul 23 2012, In : ChemBioChem. 13, 11, p. 1663-1672 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Ectopic ATP synthase blockade suppresses lung adenocarcinoma growth by activating the unfolded protein response

Chang, H. Y., Huang, H. C., Huang, T. C., Yang, P. C., Wang, Y. C. & Juan, H. F., Sep 15 2012, In : Cancer Research. 72, 18, p. 4696-4706 11 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Erratum: Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR (FEBS Letters (2011) 585 (3582-3586))

Huang, T. C., Chang, H. Y., Chen, C. Y., Wu, P. Y., Lee, H., Liao, Y. F., Hsu, W. M., Huang, H. C. & Juan, H. F., Jan 2 2012, In : FEBS Letters. 586, 1, p. 107 1 p.

Research output: Contribution to journalArticle

Human papilloma virus 16 E6 oncoprotein associated with p53 inactivation in colorectal cancer

Chen, T. H., Huang, C. C., Yeh, K. T., Chang, S. H., Chang, S. W., Sung, W. W., Cheng, Y. W. & Lee, H., 2012, In : World Journal of Gastroenterology. 18, 30, p. 4051-4058 8 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Integrin-Mediated Actions of Thyroid Hormone Analogues on Tumor Cell Chemosensitivity, Integrin-Growth Factor Receptor Crosstalk and Inflammatory Gene Expression.

Hercbergs, A., Davis, F. B., Lin, H-Y., Luidens, M. K., Meng, R., Ashur-Fabian, O., Mousa, S. A. & Davis, P. J., 2012, In : Cancer and Clinical Oncology . 1, p. 32-40 9 p.

Research output: Contribution to journalArticle

Loss of TIMP-3 promotes tumor invasion via elevated IL-6 production and predicts poor survival and relapse in HPV-infected non-small cell lung cancer

Wu, D. W., Tsai, L. H., Chen, P. M., Lee, M. C., Wang, L., Chen, C. Y., Cheng, Y. W. & Lee, H., Nov 2012, In : American Journal of Pathology. 181, 5, p. 1796-1806 11 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Markers for efficacy of mammalian target of rapamycin inhibitor

Liao, Y. M., Sy, A. & Yen, Y., Oct 2012, In : Anticancer Research. 32, 10, p. 4235-4244 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Ribonucleotide reductase and non-small cell lung cancer

Hsu, N. Y., Lee, H., Cheng, Y. W. & Yen, Y., Jan 1 2012, In : Chinese Journal of Lung Cancer. 15, 11, p. 619-623 5 p.

Research output: Contribution to journalArticle

RRM2B suppresses activation of the oxidative stress pathway and is Up-regulated by P53 during senescence

Kuo, M. L., Sy, A. J., Xue, L., Chi, M., Michelle, M. T., Yen, T., Chiang, M. I., Chang, L., Chu, P. & Yen, Y., Nov 22 2012, In : Scientific Reports. 2, 822.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Synthesis and biological evaluation of 1-arylsulfonyl-5-(N -hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo

Lai, M. J., Huang, H. L., Pan, S. L., Liu, Y. M., Peng, C. Y., Lee, H. Y., Yeh, T. K., Huang, P. H., Teng, C. M., Chen, C. S., Chuang, H. Y. & Liou, J. P., Apr 26 2012, In : Journal of Medicinal Chemistry. 55, 8, p. 3777-3791 15 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

The APE1 Asp/Asp genotype and the combination of APE1 Asp/Asp and hOGG1-Cys variants are associated with increased p53 mutation in non-small cell lung cancer

Lin, C. H., Chen, P. M., Cheng, Y. W., Chen, C. Y., Yuan, C. J. & Lee, H., 2012, In : Journal of Epidemiology. 22, 6, p. 537-542 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2013

Activated PAR-2 regulates pancreatic cancer progression through ILK/HIF-α-induced TGF-α expression and MEK/VEGF-a-mediated angiogenesis

Chang, L. H., Pan, S. L., Lai, C. Y., Tsai, A. C. & Teng, C. M., Aug 2013, In : American Journal of Pathology. 183, 2, p. 566-575 10 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Activation of a novel ubiquitin-independent proteasome pathway when RNA polymerase II encounters a protein roadblock

Ban, Y., Ho, C. W., Lin, R. K., Lyu, Y. L. & Liu, L-F., 2013, In : Molecular and Cellular Biology. 33, 20, p. 4008-4016 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Activation of NF-κB by SOD2 promotes the aggressiveness of lung adenocarcinoma by modulating NKX2-1-mediated IKKβ expression

Chen, P. M., Wu, T. C., Wang, Y. C., Cheng, Y. W., Sheu, G. T., Chen, C. Y. & Lee, H., Nov 2013, In : Carcinogenesis. 34, 11, p. 2655-2663 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway in high-grade liposarcoma

Zhang, K., Chu, K., Wu, X., Gao, H., Wang, J., Yuan, Y. C., Loera, S., Ho, K., Wang, Y., Chow, W., Un, F., Chu, P. & Yen, Y., Jan 15 2013, In : Cancer Research. 73, 4, p. 1298-1307 10 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Association of epidermal growth factor receptor mutations with human papillomavirus 16/18 E6 oncoprotein expression in non-small cell lung cancer

Tung, M. C., Wu, H. H., Cheng, Y. W., Wang, L., Chen, C. Y., Yeh, S. D., Wu, T. C. & Lee, H., Sep 15 2013, In : Cancer. 119, 18, p. 3367-3376 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

BPDE-like DNA adduct level in oral tissue may act as a risk biomarker of oral cancer

Chuang, C. Y., Tung, J. N., Su, M. C., Wu, B. C., Hsin, C. H., Chen, Y. J., Yeh, K. T., Lee, H. & Cheng, Y. W., Jan 2013, In : Archives of Oral Biology. 58, 1, p. 102-109 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Carboxyl-terminal modulator protein positively regulates Akt phosphorylation and acts as an oncogenic driver in breast cancer

Liu, Y. P., Liao, W. C., Ger, L. P., Chen, J. C., Hsu, T. I., Lee, Y. C., Chang, H. T., Chen, Y. C., Jan, Y. H., Lee, K. H., Zeng, Y. H., Hsiao, M. & Lu, P. J., Oct 15 2013, In : Cancer Research. 73, 20, p. 6194-6205 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Chromosomal Instability Triggered by Rrm2b Loss Leads to IL-6 Secretion and Plasmacytic Neoplasms

Chang, L., Guo, R., Huang, Q. & Yen, Y., May 30 2013, In : Cell Reports. 3, 5, p. 1389-1397 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Depletion of 4E-BP1 and regulation of autophagy lead to YXM110-induced anticancer effects

Lai, C. Y., Pan, S. L., Yang, X. M., Chang, L. H., Chang, Y. L., Yang, P. C., Lee, K. H. & Teng, C. M., Sep 2013, In : Carcinogenesis. 34, 9, p. 2050-2060 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Different impact of IL10 haplotype on prognosis in lung squamous cell carcinoma and adenocarcinoma

Wang, Y. C., Sung, W. W., Wang, L., Cheng, Y. W., Chen, C. Y., Wu, T. C., Shieh, S. H. & Lee, H., Jun 2013, In : Anticancer Research. 33, 6, p. 2729-2736 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Furanylazaindoles: Potent anticancer agents in vitro and in vivo

Lee, H. Y., Pan, S. L., Su, M-C., Liu, Y-M., Kuo, C-C., Chang, Y-T., Wu, J-S., Nien, C-Y., Mehndiratta, S., Chang, C-Y., Wu, S-Y., Lai, M-J., Chang, J-Y. & Liou, J. P., 2013, In : Journal of Medicinal Chemistry. 56, 20, p. 8008-8018 11 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Human Papillomavirus Up-Regulates MMP-2 and MMP-9 Expression and Activity by Inducing Interleukin-8 in Lung Adenocarcinomas

Shiau, M. Y., Fan, L. C., Yang, S. C., Tsao, C. H., Lee, H., Cheng, Y. W., Lai, L. C. & Chang, Y. H., Jan 21 2013, In : PLoS One. 8, 1, e54423.

Research output: Contribution to journalArticle

18 Citations (Scopus)

IL-10 promotes tumor aggressiveness via upregulation of CIP2A transcription in lung adenocarcinoma

Sung, W. W., Wang, Y. C., Lin, P. L., Cheng, Y. W., Chen, C. Y., Wu, T. C. & Lee, H., Aug 1 2013, In : Clinical Cancer Research. 19, 15, p. 4092-4103 12 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Incomplete success of angioinhibitor therapy in cancer: Estimation of contribution of pro-angiogenic activity of patient thyroid hormone

Davis, P. J., Yalcin, M., Lin, H. Y., Tang, H. Y., Hercbergs, A., Leith, J. T., Davis, F. B., Luidens, M. K. & Mousa, S. A., 2013, In : Journal of Cancer Science and Therapy. 5, 12, p. 441-445 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Mechanisms of ceramide-induced COX-2-dependent apoptosis in human ovarian cancer OVCAR-3 cells partially overlapped with resveratrol

Lin, H. Y., Delmas, D., Vang, O., Hsieh, T. C., Lin, S., Cheng, G. Y., Chiang, H. L., Chen, C. E., Tang, H. Y., Crawford, D. R., Whang-Peng, J., Hwang, J., Liu, L. F. & Wu, J. M., Aug 2013, In : Journal of Cellular Biochemistry. 114, 8, p. 1940-1954 15 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

MicroRNA-320 suppresses the stem cell-like characteristics of prostate cancer cells by downregulating the Wnt/beta-catenin signaling pathway

Hsieh, I. S., Chang, K. C., Tsai, Y. T., Ke, J. Y., Lu, P. J., Lee, K. H., Yeh, S. D., Hong, T. M. & Chen, Y. L., Mar 2013, In : Carcinogenesis. 34, 3, p. 530-538 9 p.

Research output: Contribution to journalArticle

150 Citations (Scopus)

MicroRNA-657 promotes tumorigenesis in hepatocellular carcinoma by targeting transducin-like enhancer protein 1 through nuclear factor kappa B pathways

Zhang, L., Yang, L., Liu, X., Chen, W., Chang, L., Chen, L., Loera, S., Chu, P., Huang, W. C., Liu, Y. R. & Yen, Y., May 1 2013, In : Hepatology. 57, 5, p. 1919-1930 12 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

MnSOD promotes tumor invasion via upregulation of FoxM1-MMP2 axis and related with poor survival and relapse in lung adenocarcinomas

Chen, P. M., Wu, T. C., Shieh, S. H., Wu, Y. H., Li, M. C., Sheu, G. T., Cheng, Y. W., Chen, C. Y. & Lee, H., Mar 2013, In : Molecular Cancer Research. 11, 3, p. 261-271 11 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Molecular mechanisms of actions of formulations of the thyroid hormone analogue, tetrac, on the inflammatory response

Davis, P. J., Glinsky, G. V., Lin, H. Y., Incerpi, S., Davis, F. B., Mousa, S. A., Tang, H. Y., Hercbergs, A. & Luidens, M. K., 2013, In : Endocrine Research. 38, 2, p. 112-118 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Moscatilin inhibits migration and metastasis of human breast cancer MDA-MB-231 cells through inhibition of Akt and Twist signaling pathway

Pai, H. C., Chang, L. H., Peng, C. Y., Chang, Y. L., Chen, C. C., Shen, C. C., Teng, C. M. & Pan, S. L., Mar 2013, In : Journal of Molecular Medicine. 91, 3, p. 347-356 10 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Nuclear monomeric integrin αv in cancer cells is a coactivator regulated by thyroid hormone

Lin, H. Y., Su, Y. F., Hsieh, M. T., Lin, S., Meng, R., London, D., Lin, C., Tang, H. Y., Hwang, J., Davis, F. B., Mousa, S. A. & Davis, P. J., Aug 2013, In : FASEB Journal. 27, 8, p. 3209-3216 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Optimization of global DNA methylation measurement by LC-MS/MS and its application in lung cancer patients

Hu, C. W., Lee, H., Chen, J. L., Li, Y. J. & Chao, M. R., 2013, In : Analytical and Bioanalytical Chemistry. 405, 27, p. 8859-8869 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)