Ph.D. Program for Cancer Molecular Biology and Drug Discovery

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2020

A site-moiety map and virtual screening approach for discovery of novel 5-LOX inhibitors

Hsu, K. C., HuangFu, W. C., Lin, T. E., Chao, M. W., Sung, T. Y., Chen, Y. Y., Pan, S. L., Lee, J. C., Tzou, S. C., Sun, C. M. & Yang, J. M., Dec 1 2020, In : Scientific Reports. 10, 1, 10510.

Research output: Contribution to journalArticle

Open Access

Astragalus membranaceus-Derived Anti-Programmed Death-1 Monoclonal Antibodies with Immunomodulatory Therapeutic Effects against Tumors

Chang, F. L., Tsai, K. C., Lin, T. Y., Yang, T. W., Lo, Y. N., Chen, W. C., Chang, J. H., Lu, M. K., Chiou, C. T., Chen, P. H., Yen, Y., Pan, S. L. & Lee, Y. C., Jan 1 2020, In : BioMed Research International. 2020, 3415471.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

CC12 induces apoptotic cell death and cell cycle arrest in human glioblastoma cell lines and mouse xenograft model

Fann, L. Y., Shih, J. H., Tseng, J. H., Huang, H. S. & Hsiao, S. H., Apr 2020, In : Molecules. 25, 8, 25081793.

Research output: Contribution to journalArticle

Open Access

Chondroitin sulfate proteoglycan 4 regulates zebrafish body axis organization via Wnt/ planar cell polarity pathway

Lee, Y. H., Kawakami, K., HuangFu, W. C. & Liu, I. H., Jan 1 2020, In : PLoS ONE. 15, 4, e0230943.

Research output: Contribution to journalArticle

Open Access

Clinical-grade cryopreserved doxorubicin-loaded platelets: Role of cancer cells and platelet extracellular vesicles activation loop

Wu, Y. W., Huang, C. C., Changou, C. A., Lu, L. S., Goubran, H. & Burnouf, T., Mar 23 2020, In : Journal of Biomedical Science. 27, 1, p. 45 45.

Research output: Contribution to journalArticle

Open Access

Gene signatures and potential therapeutic targets of amino acid metabolism in estrogen receptor-positive breast cancer

Wang, C-Y., Chiao, C-C., Phan, N. N., Li, C-Y., Sun, Z-D., Jiang, J-Z., Hung, J-H., Chen, Y-L., Yen, M-C., Weng, T-Y., Chen, W-C., Hsu, H-P. & Lai, M-D., 2020, In : American Journal of Cancer Research. 10, 1, p. 95-113 19 p.

Research output: Contribution to journalArticle

Gene signatures of SARS-CoV/SARS-CoV-2-infected ferret lungs in short- and long-term models

Liu, H. L., Yeh, I. J., Phan, N. N., Wu, Y. H., Yen, M. C., Hung, J. H., Chiao, C. C., Chen, C. F., Sun, Z., Jiang, J. Z., Hsu, H. P., Wang, C. Y. & Lai, M. D., Nov 2020, In : Infection, Genetics and Evolution. 85, 104438.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Knockdown of serine/threonine-protein kinase 24 promotes tumorigenesis and myeloid-derived suppressor cell expansion in an orthotopic immunocompetent gastric cancer animal model

Hsu, H. P., Wang, C. Y., Hsieh, P. Y., Fang, J. H. & Chen, Y. L., Jan 1 2020, In : Journal of Cancer. 11, 1, p. 213-228 16 p.

Research output: Contribution to journalArticle

Open Access

Long-term Proton Pump Inhibitor Administration Caused Physiological and Microbiota Changes in Rats

Yang, Y. C. S. H., Chang, H. W., Lin, I. H., Chien, L. N., Wu, M. J., Liu, Y. R., Chu, P. G., Xie, G., Dong, F., Jia, W., Chang, V. H. S. & Yen, Y., Dec 1 2020, In : Scientific Reports. 10, 1, 866.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Melatonin activates cell death programs for the suppression of uterine leiomyoma cell proliferation

Lin, P. H., Tung, Y. T., Chen, H. Y., Chiang, Y. F., Hong, H. C., Huang, K. C., Hsu, S. P., Huang, T. C. & Hsia, S. M., Jan 1 2020, In : Journal of Pineal Research. 68, 1, p. e12620 e12620.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Molybdenum doping effects for bismuth vanadate photocatalysts on electrochemical performances using the solution process

Chen, Y. S., Lin, L. Y. & Lin, H. Y., Jan 1 2020, In : International Journal of Hydrogen Energy. 45, 1, p. 667-674 8 p.

Research output: Contribution to journalArticle

Open Access

Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs

Yang, C. P., Yang, W. S., Wong, Y. H., Wang, K. H., Teng, Y. C., Chang, M. H., Liao, K. H., Nian, F. S., Chao, C. C., Tsai, J. W., Hwang, W. L., Lin, M. W., Tzeng, T. Y., Wang, P. N., Campbell, M., Chen, L. K., Tsai, T. F., Chang, P. C. & Kung, H. J., May 1 2020, In : Aging Cell. 19, 5, e13107.

Research output: Contribution to journalArticle

Open Access

N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression

Mehndiratta, S., Lin, M. H., Wu, Y. W., Chen, C. H., Wu, T. Y., Chuang, K. H., Chao, M. W., Chen, Y. Y., Pan, S. L., Chen, M. C. & Liou, J. P., Jan 1 2020, In : European Journal of Medicinal Chemistry. 185, p. 111725 111725.

Research output: Contribution to journalArticle

6 Citations (Scopus)
1 Citation (Scopus)
Open Access

Sorafenib inhibits ribonucleotide reductase regulatory subunit M2 (RRM2) in hepatocellular carcinoma cells

Yang, P. M., Lin, L. S. & Liu, T. P., Jan 2020, In : Biomolecules. 10, 1, 117.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Structural insight into the differential interactions between the DNA mimic protein SAUGI and two gamma herpesvirus uracil-DNA glycosylases

Liao, Y. T., Lin, S. J., Ko, T. P., Liu, C. Y., Hsu, K. C. & Wang, H. C., Oct 1 2020, In : International Journal of Biological Macromolecules. 160, p. 903-914 12 p.

Research output: Contribution to journalArticle

Open Access

Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease

Tseng, H. J., Lin, M. H., Shiao, Y. J., Yang, Y. C., Chu, J. C., Chen, C. Y., Chen, Y. Y., Lin, T. E., Su, C. J., Pan, S. L., Chen, L. C., Wang, C. Y., Hsu, K. C. & Huang, W. J., Apr 15 2020, In : European Journal of Medicinal Chemistry. 192, p. 112193 112193.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Temporal expression patterns of distinct cytokines and M1/M2 macrophage polarization regulate rheumatoid arthritis progression

Kung, C. C., Dai, S. P., Chiang, H., Huang, H. S. & Sun, W. H., Jan 1 2020, (Accepted/In press) In : Molecular Biology Reports.

Research output: Contribution to journalArticle

Open Access

Two first-in-human studies of xentuzumab, a humanised insulin-like growth factor (IGF)-neutralising antibody, in patients with advanced solid tumours

de Bono, J., Lin, C. C., Chen, L. T., Corral, J., Michalarea, V., Rihawi, K., Ong, M., Lee, J. H., Hsu, C. H., Yang, J. C. H., Shiah, H. S., Yen, C. J., Anthoney, A., Jove, M., Buschke, S., Fuertig, R., Schmid, U., Goeldner, R. G., Strelkowa, N., Huang, D. C. L. & 3 others, Bogenrieder, T., Twelves, C. & Cheng, A. L., Apr 28 2020, In : British Journal of Cancer. 122, 9, p. 1324-1332 9 p.

Research output: Contribution to journalArticle

Open Access

Upregulation of protein synthesis and proteasome degradation confers sensitivity to proteasome inhibitor bortezomib in myc-atypical teratoid/rhabdoid tumors

Tran, H. M., Wu, K. S., Sung, S. Y., Changou, C. A., Hsieh, T. H., Liu, Y. R., Liu, Y. L., Tsai, M. L., Lee, H. L., Hsieh, K. L. C., Huang, W. C., Liang, M. L., Chen, H. H., Lee, Y. Y., Lin, S. C., Ho, D. M. T., Chang, F. C., Chao, M. E., Chen, W., Chu, S. S. & 4 others, Yu, A. L., Yen, Y., Chang, C. C. & Wong, T. T., Mar 22 2020, In : Cancers. 12, 3, 752.

Research output: Contribution to journalArticle

Open Access
2019

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Action of Reverse T3 on Cancer Cells

Lin, H. Y., Tang, H. Y., Leinung, M., Mousa, S. A., Hercbergs, A. & Davis, P. J., Jan 1 2019, In : Endocrine Research.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Alternative splicing in human cancer cells is modulated by the amiloride derivative 3,5-diamino-6-chloro-N-(N-(2,6-dichlorobenzoyl)carbamimidoyl)pyrazine-2-carboxide

Lee, C. C., Chang, W. H., Chang, Y. S., Yang, J. M., Chang, C. S., Hsu, K. C., Chen, Y. T., Liu, T. Y., Chen, Y. C., Lin, S. Y., Wu, Y. C. & Chang, J. G., Jan 1 2019, In : Molecular Oncology. 13, 8, p. 1744-1762 19 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Androgen deprivation-induced ZBTB46-PTGS1 signaling promotes neuroendocrine differentiation of prostate cancer

Chen, W. Y., Zeng, T., Wen, Y. C., Yeh, H. L., Jiang, K. C., Chen, W. H., Zhang, Q., Huang, J. & Liu, Y. N., Jan 1 2019, In : Cancer Letters. 440-441, p. 35-46 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
Open Access
2 Citations (Scopus)
Open Access

Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivo

Hsieh, Y. L., Tu, H. J., Pan, S. L., Liou, J. P. & Yang, C. R., Jun 1 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 6, p. 992-1003 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Association of matrix Metalloproteinase-9 rs3918242 promoter genotypes with colorectal cancer risk

Wu, M. H., Tzeng, H. E., Wu, C. N., Yueh, T. C., Peng, Y. C., Tsai, C. H., Wang, Y. C., Ke, T. W., Pei, J. S., Chang, W. S., Tsai, C. W. & Bau, D. T., Jan 1 2019, In : Anticancer Research. 39, 12, p. 6523-6529 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Chicken-Derived Humanized Antibody Targeting a Novel Epitope F2pep of Fibroblast Growth Factor Receptor 2: Potential Cancer Therapeutic Agent

Tsai, K. C., Chang, C. D., Cheng, M. H., Lin, T. Y., Lo, Y. N., Yang, T. W., Chang, F. L., Chiang, C. W., Lee, Y. C. & Yen, Y., Jan 31 2019, In : ACS Omega. 4, 1, p. 2387-2397 11 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Comparison of the biological impact of UVA and UVB upon the skin with functional proteomics and immunohistochemistry

Wang, P. W., Hung, Y. C., Lin, T. Y., Fang, J. Y., Yang, P. M., Chen, M. H. & Pan, T. L., Dec 2019, In : Antioxidants. 8, 12, 569.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Dental Pulp Stem Cell Transplantation with 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside Accelerates Alveolar Bone Regeneration in Rats

Lin, C. Y., Kuo, P. J., Chin, Y. T., Weng, I. T., Lee, H. W., Huang, H. M., Lin, H. Y., Hsiung, C. N., Chan, Y. H. & Lee, S. Y., Apr 1 2019, In : Journal of Endodontics. 45, 4, p. 435-441 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Dietary flavonoids luteolin and quercetin inhibit migration and invasion of squamous carcinoma through reduction of src/stat3/s100a7 signaling

Fan, J. J., Hsu, W. H., Lee, K. H., Chen, K. C., Lin, C. W., Lee, Y. L. A., Ko, T. P., Lee, L. T., Lee, M. T., Chang, M. S. & Cheng, C. H., Nov 2019, In : Antioxidants. 8, 11, 557.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Differential effect of herbal tea extracts on free fatty acids-, ethanol- and acetaminophen-induced hepatotoxicity in FL83B hepatocytes

Chen, G. W., Chen, T. Y. & Yang, P. M., Jan 1 2019, (Accepted/In press) In : Drug and Chemical Toxicology.

Research output: Contribution to journalArticle

Does long-term use of antidiabetic drugs changes cancer risk?

Liu, Y. C., Nguyen, P. A., Humayun, A., Chien, S. C., Yang, H. C., Asdary, R. N., Syed-Abdul, S., Hsu, M. H., Moldovan, M., Yen, Y., Li, Y. C., Jian, W. S. & Iqbal, U., Oct 1 2019, In : Medicine (United States). 98, 40, p. e17461 e17461.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Dysregulation of cystathionine γ-lyase promotes prostate cancer progression and metastasis

Wang, Y. H., Huang, J. T., Chen, W. L., Wang, R. H., Kao, M. C., Pan, Y. R., Chan, S. H., Tsai, K. W., Kung, H. J., Lin, K. T. & Wang, L. H., Oct 4 2019, In : EMBO Reports. 20, 10, e45986.

Research output: Contribution to journalArticle

Open Access
Open Access
2 Citations (Scopus)
Open Access

Histone demethylase KDM4C stimulates the proliferation of prostate cancer cells via activation of AKT and c-Myc

Lin, C. Y., Wang, B. J., Chen, B. C., Tseng, J. C., Jiang, S. S., Tsai, K. K., Shen, Y. Y., Yuh, C. H., Sie, Z. L., Wang, W. C., Kung, H. J. & Chuu, C. P., Nov 13 2019, In : Cancers. 11, 11, 1785.

Research output: Contribution to journalArticle

Open Access