Ph.D. Program for Cancer Molecular Biology and Drug Discovery

Research output

Research output per year 1996 2021

• 10294 Citations
• 46 h-Index
• 532 Article
• 41 Review article
• 34 Patent
• 16 Comment/debate
• 15 More
  • 5 Chapter
  • 2 Book
  • 2 Paper
  • 2 Letter
  • 1 Conference contribution
  • 1 Chapter (peer-reviewed)
  • 1 Editorial
  • 1 Short survey

Research output per year

Research output per year

Search results

• 2021

  Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach

  Chao, M. W., Lin, T. E., HuangFu, W. C., Chang, C. D., Tu, H. J., Chen, L. C., Yen, S. C., Sung, T. Y., Huang, W. J., Yang, C. R., Pan, S. L. & Hsu, K. C., Dec 2021, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 36, 1, p. 98-108 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Phosphotransferases
  • Cell Cycle Resting Phase
  • Enzyme Assays
  • G1 Phase
  • Neoplasms

• Investigation of Selected Flavonoid Derivatives as Potent FLT3 Inhibitors for the Potential Treatment of Acute Myeloid Leukemia

  Yen, S. C., Chen, L. C., Huang, H. L., Ngo, S. T., Wu, Y. W., Lin, T. E., Sung, T. Y., Lien, S. T., Tseng, H. J., Pan, S. L., Huang, W. J. & Hsu, K. C., Jan 22 2021, In: Journal of Natural Products. 84, 1, p. 1-10 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Flavonoids
  • Acute Myeloid Leukemia
  • Protein-Tyrosine Kinases
  • Derivatives
  • 6-methoxyflavone

• Nerve growth factor interacts with CHRM4 and promotes neuroendocrine differentiation of prostate cancer and castration resistance

  Chen, W. Y., Wen, Y. C., Lin, S. R., Yeh, H. L., Jiang, K. C., Chen, W. H., Lin, Y. S., Zhang, Q., Liew, P. L., Hsiao, M., Huang, J. & Liu, Y. N., Dec 2021, In: Communications Biology. 4, 1, 22.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • prostatic neoplasms
  • nerve growth factor
  • cholinergic receptors
  • castration
  • Castration

• Severe acute respiratory syndrome coronavirus (Sars-cov)-2 infection induces dysregulation of immunity: In silico gene expression analysis

  Wu, Y. H., Yeh, I. J., Phan, N. N., Yen, M. C., Liu, H. L., Wang, C. Y. & Hsu, H. P., 2021, In: International Journal of Medical Sciences. 18, 5, p. 1143-1152 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Coronavirus Infections
  • Severe Acute Respiratory Syndrome
  • Coronavirus
  • Computer Simulation
  • Immunity

• Upregulation of peroxisome proliferator-activated receptor-α and the lipid metabolism pathway promotes carcinogenesis of ampullary cancer

  Wang, C. Y., Chao, Y. J., Chen, Y. L., Wang, T. W., Phan, N. N., Hsu, H. P., Shan, Y. S. & Lai, M. D., 2021, In: International Journal of Medical Sciences. 18, 1, p. 256-269 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Peroxisome Proliferator-Activated Receptors
  • Lipid Metabolism
  • Carcinogenesis
  • Up-Regulation
  • PPAR alpha
• 2020

  13-acetoxysarcocrassolide exhibits cytotoxic activity against oral cancer cells through the interruption of the keap1/Nrf2/p62/SQSTM1 pathway: The need to move beyond classical concepts

  Liu, Y. C., Peng, B. R., Hsu, K. C., El-Shazly, M., Shih, S. P., Lin, T. E., Kuo, F. W., Chou, Y. C., Lin, H. Y. & Lu, M. C., Jul 23 2020, In: Marine Drugs. 18, 8, 382.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 13-acetoxysarcocrassolide
  • Mouth Neoplasms
  • Reactive Oxygen Species
  • Tumor Burden
  • Small Interfering RNA

• 2,3,5,4′-Tetrahydroxystilbene-2-O-β-d-glucoside promotes the effects of dental pulp stem cells on rebuilding periodontal tissues in experimental periodontal defects

  Lin, C. Y., Tsai, M. S., Kuo, P. J., Chin, Y. T., Weng, I. T., Wu, Y., Huang, H. M., Hsiung, C. N., Lin, H. Y. & Lee, S. Y., 2020, In: Journal of Periodontology.

  Research output: Contribution to journal › Article › peer-review

  • 2,3,5,4'-tetrahydroxystilbene 2-O-glucopyranoside
  • Dental Pulp
  • Stem Cells
  • X-Ray Microtomography
  • Osteogenesis

• 8‐hydroxydaidzein, an isoflavone from fermented soybean, induces autophagy, apoptosis, differentiation, and degradation of oncoprotein bcr‐abl in k562 cells

  Wu, P. S., Yen, J. H., Wang, C. Y., Chen, P. Y., Hung, J. H. & Wu, M. J., Nov 2020, In: Biomedicines. 8, 11, p. 1-23 23 p., 506.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Isoflavones
  • Soybeans
  • K562 Cells
  • Oncogene Proteins
  • Autophagy
  1 Citation (Scopus)

• Actions of l-thyroxine (T4) and tetraiodothyroacetic acid (tetrac) on gene expression in thyroid cancer cells

  Davis, P. J., Lin, H. Y., Hercbergs, A. & Mousa, S. A., Jul 2020, In: Genes. 11, 7, p. 1-9 9 p., 755.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • tetraiodothyroacetic acid
  • Thyroxine
  • Thyroid Neoplasms
  • Thyroid Hormones
  • Integrins
  1 Citation (Scopus)

• A Phase II Clinical Trial on the Combination Therapy of PHY906 Plus Capecitabine in Hepatocellular Carcinoma

  Changou, C. A., Shiah, H. S., Chen, L. T., Liu, S., Luh, F., Liu, S. H., Cheng, Y. C. & Yen, Y., 2020, (Accepted/In press) In: Oncologist.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • PHY 906
  • Capecitabine
  • Phase II Clinical Trials
  • Hepatocellular Carcinoma
  • Progression-Free Survival
  1 Citation (Scopus)

• A site-moiety map and virtual screening approach for discovery of novel 5-LOX inhibitors

  Hsu, K. C., HuangFu, W. C., Lin, T. E., Chao, M. W., Sung, T. Y., Chen, Y. Y., Pan, S. L., Lee, J. C., Tzou, S. C., Sun, C. M. & Yang, J. M., Jun 29 2020, In: Scientific Reports. 10, 1, p. 10510 10510.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Arachidonate 5-Lipoxygenase
  • Lipoxygenase Inhibitors
  • Screening
  • Anchors
  • Anti-Inflammatory Agents

• Astragalus membranaceus-Derived Anti-Programmed Death-1 Monoclonal Antibodies with Immunomodulatory Therapeutic Effects against Tumors

  Chang, F. L., Tsai, K. C., Lin, T. Y., Yang, T. W., Lo, Y. N., Chen, W. C., Chang, J. H., Lu, M. K., Chiou, C. T., Chen, P. H., Yen, Y., Pan, S. L. & Lee, Y. C., Jan 1 2020, In: BioMed Research International. 2020, 3415471.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Astragalus propinquus
  • Tumors
  • Single-Chain Antibodies
  • Polysaccharides
  • Therapeutic Uses
  5 Citations (Scopus)

• Bioinformatics data mining repurposes the JAK2 (Janus kinase 2) inhibitor fedratinib for treating pancreatic ductal adenocarcinoma by reversing the KRAS (kirsten rat sarcoma 2 viral oncogene homolog)-driven gene signature

  Liu, L. W., Hsieh, Y. Y. & Yang, P. M., Sep 16 2020, In: Journal of Personalized Medicine. 10, 3, p. 1-17 17 p., 130.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • TG101348
  • Janus Kinase Inhibitors
  • Janus Kinase 2
  • Data Mining
  • Computational Biology

• Biological Evaluation of Selected Flavonoids as Inhibitors of MNKs Targeting Acute Myeloid Leukemia

  Chen, L. C., Huang, H. L., Huangfu, W. C., Yen, S. C., Ngo, S. T., Wu, Y. W., Lin, T. E., Sung, T. Y., Lien, S. T., Tseng, H. J., Pan, S. L., Huang, W. J. & Hsu, K. C., Oct 23 2020, In: Journal of Natural Products. 83, 10, p. 2967-2975 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Luteolin
  • hispidulin
  • Phosphorylation
  • Flavonoids
  • Acute Myeloid Leukemia

• CC12 induces apoptotic cell death and cell cycle arrest in human glioblastoma cell lines and mouse xenograft model

  Fann, L. Y., Shih, J. H., Tseng, J. H., Huang, H. S. & Hsiao, S. H., Apr 2020, In: Molecules. 25, 8, 25081793.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cell death
  • cultured cells
  • death
  • apoptosis
  • mice

• Chondroitin sulfate proteoglycan 4 regulates zebrafish body axis organization via Wnt/ planar cell polarity pathway

  Lee, Y. H., Kawakami, K., HuangFu, W. C. & Liu, I. H., Jan 1 2020, In: PLoS ONE. 15, 4, e0230943.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • chondroitin sulfate proteoglycan 4
  • cell polarity
  • Cell Polarity
  • chondroitin sulfate
  • proteoglycans
  1 Citation (Scopus)

• Clinical-grade cryopreserved doxorubicin-loaded platelets: Role of cancer cells and platelet extracellular vesicles activation loop

  Wu, Y. W., Huang, C. C., Changou, C. A., Lu, L. S., Goubran, H. & Burnouf, T., Mar 23 2020, In: Journal of Biomedical Science. 27, 1, p. 45 45.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Platelets
  • Extracellular Vesicles
  • Cells
  • Doxorubicin
  • Chemical activation
  2 Citations (Scopus)

• Contribution of Matrix Metalloproteinase-9 rs3918242 Genotypes to Childhood Leukemia Risk

  Kuo, C. C., Tsai, C. W., Chang, W. S., Shen, T. C., Tzeng, H. E., Li, C. H., Wang, Y. C., Tsai, F. J. & Bau, DA. T., Oct 1 2020, In: Anticancer Research. 40, 10, p. 5751-5756 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Matrix Metalloproteinase 9
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Matrix Metalloproteinases
  • Leukemia
  • Genotype

• Coronaviruses and Integrin αvβ3: Does Thyroid Hormone Modify the Relationship?

  Davis, P. J., Lin, H. Y., Hercbergs, A., Keating, K. A. & Mousa, S. A., Jul 2 2020, In: Endocrine Research. 45, 3, p. 210-215 6 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Coronavirus
  • Thyroid Hormones
  • Integrins
  • angiotensin converting enzyme 2
  • Virus Attachment
  1 Citation (Scopus)

• Correction: Role of integrin-linked kinase in regulating the protein stability of the MUC1-C oncoprotein in pancreatic cancer cells (Oncogenesis, (2017), 6, 7, (e359), 10.1038/oncsis.2017.61)

  Huang, H. L., Wu, H. Y., Chu, P. C., Lai, I. L., Huang, P. H., Kulp, S. K., Pan, S. L., Teng, C. M. & Chen, C. S., Feb 1 2020, In: Oncogenesis. 9, 2, 27.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • integrin-linked kinase
  • Protein Stability
  • Oncogene Proteins
  • Pancreatic Neoplasms
  • Interleukin-6

• Corrigendum to: TW-01, a piperazinedione-derived compound, inhibits Ras-mediated cell proliferation and angioplasty-induced vascular restenosis “Toxicol Appl Pharmacol. 2016;305:194–202” (Toxicology and Applied Pharmacology (2016) 305 (194–202)(S0041008X16301478)(10.1016/j.taap.2016.06.013))

  Lin, C. F., Huang, H. L., Peng, C. Y., Lee, Y. C., Wang, H. P., Teng, C. M. & Pan, S. L., Jan 15 2020, In: Toxicology and Applied Pharmacology. 387, 114858.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • 3,6-bis(5-chloro-2-piperidyl)-2,5-piperazinedione
  • Cell proliferation
  • Drug Discovery
  • Molecular biology
  • Angioplasty

• Corrigendum to “1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma” [Eur. J. Med. Chem. 140 (2017) 84–91](S0223523417306931)(10.1016/j.ejmech.2017.09.011)

  Liu, Y. M., HuangFu, W. C., Huang, H. L., Wu, W. C., Chen, Y. L., Yen, Y., Huang, H. L., Nien, C. Y., Lai, M. J., Pan, S. L. & Liou, J. P., Sep 15 2020, In: European Journal of Medicinal Chemistry. 202, 112633.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • 1,4-naphthoquinone
  • benzamide
  • Ubiquitin-Protein Ligases
  • Tumors
  • Multiple Myeloma

• Corrigendum to“Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo”[Eur. J. Med. Chem. 190 (2020 Mar 15) 112086] (European Journal of Medicinal Chemistry (2020) 190, (S0223523420300532), (10.1016/j.ejmech.2020.112086))

  Ojha, R., Nepali, K., Chen, C. H., Chuang, K. H., Wu, T. Y., Lin, T. E., Hsu, K. C., Chao, M. W., Lai, M. J., Lin, M. H., Huang, H. L., Chang, C. D., Pan, S. L., Chen, M. C. & Liou, J. P., Sep 1 2020, In: European Journal of Medicinal Chemistry. 201, 112404.

  Research output: Contribution to journal › Comment/debate › peer-review

  • Pharmaceutical Chemistry
  • Scaffolds
  • Herbal Medicine
  • Pharmacy
  • Taiwan

• Corrigendum to “N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression”[Eur. J. Med. Chem. 2020 Jan 1;185:111725] (European Journal of Medicinal Chemistry (2020) 185, (S0223523419308773), (10.1016/j.ejmech.2019.111725))

  Mehndiratta, S., Lin, M. H., Wu, Y. W., Chen, C. H., Wu, T. Y., Chuang, K. H., Chao, M. W., Chen, Y. Y., Pan, S. L., Chen, M. C. & Liou, J. P., Aug 1 2020, In: European Journal of Medicinal Chemistry. 199, 112406.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Anilides
  • Pharmaceutical Chemistry
  • Histone Deacetylase Inhibitors
  • Herbal Medicine
  • Pharmacy
  1 Citation (Scopus)

• Dicoumarol suppresses HMGA2-mediated oncogenic capacities and inhibits cell proliferation by inducing apoptosis in colon cancer

  Chen, C. H., Hsieh, Y. C., Yang, P. M., Liu, Y. R. & Cho, E. C., 2020, In: Biochemical and Biophysical Research Communications.

  Research output: Contribution to journal › Article › peer-review

  • Dicumarol
  • Cell proliferation
  • High Mobility Group Proteins
  • Oxidative stress
  • Colonic Neoplasms
  2 Citations (Scopus)

• Exosomal TAR DNA-binding protein-43 and neurofilaments in plasma of amyotrophic lateral sclerosis patients: A longitudinal follow-up study

  Chen, P. C., Wu, D., Hu, C. J., Chen, H. Y., Hsieh, Y. C. & Huang, C. C., Nov 15 2020, In: Journal of the Neurological Sciences. 418, p. 117070 117070.

  Research output: Contribution to journal › Article › peer-review

  • DNA-Binding Proteins
  • Intermediate Filaments
  • Amyotrophic Lateral Sclerosis
  • Light
  • Biomarkers

• Gene signatures and potential therapeutic targets of amino acid metabolism in estrogen receptor-positive breast cancer

  Wang, C-Y., Chiao, C-C., Phan, N. N., Li, C-Y., Sun, Z-D., Jiang, J-Z., Hung, J-H., Chen, Y-L., Yen, M-C., Weng, T-Y., Chen, W-C., Hsu, H-P. & Lai, M-D., 2020, In: American Journal of Cancer Research. 10, 1, p. 95-113 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptors
  • Amino Acids
  • Breast Neoplasms
  • Genes
  • Computational Biology

• Gene signatures and prognostic analyses of the tob/btg pituitary tumor-transforming gene (PTTG) family in clinical breast cancer patients

  Wu, C. C., Ekanem, T. I., Phan, N. N., Loan, D. T. T., Hou, S. Y., Lee, K. H. & Wang, C. Y., 2020, In: International Journal of Medical Sciences. 17, 18, p. 3112-3124 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pituitary Neoplasms
  • Oncogenes
  • Breast Neoplasms
  • Genes
  • Cell Cycle

• Gene signatures of SARS-CoV/SARS-CoV-2-infected ferret lungs in short- and long-term models

  Liu, H. L., Yeh, I. J., Phan, N. N., Wu, Y. H., Yen, M. C., Hung, J. H., Chiao, C. C., Chen, C. F., Sun, Z., Jiang, J. Z., Hsu, H. P., Wang, C. Y. & Lai, M. D., Nov 2020, In: Infection, Genetics and Evolution. 85, 104438.

  Research output: Contribution to journal › Article › peer-review

  • Severe acute respiratory syndrome coronavirus
  • severe acute respiratory syndrome
  • Severe Acute Respiratory Syndrome
  • Ferrets
  • ferrets
  3 Citations (Scopus)

• Identification of the Effects of Aspirin and Sulindac Sulfide on the Inhibition of HMGA2-Mediated Oncogenic Capacities in Colorectal Cancer

  Ekanem, T. I., Tsai, W. L., Lin, Y. H., Tan, W. Q., Chang, H. Y., Huang, T. C., Chen, H. Y. & Lee, K. H., Aug 22 2020, In: Molecules. 25, 17, 3826.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • sulindac sulfide
  • sulfides
  • varespladib methyl
  • cancer
  • Aspirin
  1 Citation (Scopus)

• Increased expression of secreted frizzled related protein 1 (SFRP1) predicts ampullary adenocarcinoma recurrence

  Cheng, L. C., Chao, Y. J., Overman, M. J., Wang, C. Y., Phan, N. N., Chen, Y. L., Wang, T. W., Hsu, H. P., Shan, Y. S. & Lai, M. D., Dec 1 2020, In: Scientific Reports. 10, 1, 13255.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • WD repeat containing planar cell polarity effector
  • Adenocarcinoma
  • Recurrence
  • Peritoneal Neoplasms
  • Bone Morphogenetic Proteins
  3 Citations (Scopus)

• Investigating the potential effects of selective histone deacetylase 6 inhibitor ACY1215 on infarct size in rats with cardiac ischemia-reperfusion injury

  Lin, C. F., Hsu, K. C., Huangfu, W. C., Lin, T. E., Huang, H. L. & Pan, S. L., Mar 12 2020, In: BMC Pharmacology and Toxicology. 21, 1, p. 21 21.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Histone Deacetylase 6
  • Histone Deacetylase Inhibitors
  • Reperfusion Injury
  • 3-(1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)-N-hydroxyacrylamide
  • Hypoxia-Inducible Factor 1
  1 Citation (Scopus)

• Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo

  Ojha, R., Nepali, K., Chen, C. H., Chuang, K. H., Wu, T. Y., Lin, T. E., Hsu, K. C., Chao, M. W., Lai, M. J., Lin, M. H., Huang, H. L., Chang, C. D., Pan, S. L., Chen, M. C. & Liou, J. P., Mar 15 2020, In: European Journal of Medicinal Chemistry. 190, 112086.

  Research output: Contribution to journal › Article › peer-review

  • compound 17
  • Scaffolds
  • Lung Neoplasms
  • Inhibitory Concentration 50
  • Lung
  7 Citations (Scopus)

• Isolation of anti-VEGF monoclonal antibodies with neutralizing effects from an Astragalus-induced immune antibody library

  Lee, Y. C., Huang, H. T., Chang, C. D., Chen, C. T., Lin, T. Y., Yang, T. W., Chang, F. L., Lu, M. K., Chiou, C. T., Chen, W. C., Pan, S. L. & Tsai, K. C., Nov 1 2020, In: International Immunopharmacology. 88, 107007.

  Research output: Contribution to journal › Article › peer-review

  • Endothelial Growth Factors
  • Single-Chain Antibodies
  • Vascular Endothelial Growth Factor A
  • Monoclonal Antibodies
  • Antibodies

• Knockdown of serine/threonine-protein kinase 24 promotes tumorigenesis and myeloid-derived suppressor cell expansion in an orthotopic immunocompetent gastric cancer animal model

  Hsu, H. P., Wang, C. Y., Hsieh, P. Y., Fang, J. H. & Chen, Y. L., Jan 1 2020, In: Journal of Cancer. 11, 1, p. 213-228 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Myeloid-Derived Suppressor Cells
  • Protein-Serine-Threonine Kinases
  • Stomach Neoplasms
  • Carcinogenesis
  • Animal Models
  3 Citations (Scopus)

• LDOC1 suppresses microbe-induced production of il-1β in human normal and cancerous oral cells through the PI3K/AKT/GSK-3β axis

  Lee, C. H., Hung, P. F., Liu, K. J., Chung, H. L., Yang, W. C., Hsu, K. C., Fong, T. H., Lo, H. J., Chen, Y. P., Yang, J. R. & Yen, C. Y., Nov 2020, In: Cancers. 12, 11, p. 1-20 20 p., 3148.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glycogen Synthase Kinase 3
  • Phosphatidylinositol 3-Kinases
  • Candida albicans
  • Squamous Cell Carcinoma
  • Interleukin-1

• Leucine-rich repeat containing 8A contributes to the expansion of brain ventricles in zebrafish embryos

  Tseng, Y-T., Ko, C-L., Chang, C-T., Lee, Y-H., Huang Fu, W-C. & Liu, I-H., Jan 29 2020, In: Biology Open. 9, 1

  Research output: Contribution to journal › Article › peer-review

  • Danio rerio
  • Zebrafish
  • Leucine
  • leucine
  • Brain

• Long-term Proton Pump Inhibitor Administration Caused Physiological and Microbiota Changes in Rats

  Yang, Y. C. S. H., Chang, H. W., Lin, I. H., Chien, L. N., Wu, M. J., Liu, Y. R., Chu, P. G., Xie, G., Dong, F., Jia, W., Chang, V. H. S. & Yen, Y., Dec 1 2020, In: Scientific Reports. 10, 1, 866.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proton Pump Inhibitors
  • Microbiota
  • Bile Ducts
  • High Fat Diet
  • Omeprazole
  3 Citations (Scopus)

• Melatonin activates cell death programs for the suppression of uterine leiomyoma cell proliferation

  Lin, P. H., Tung, Y. T., Chen, H. Y., Chiang, Y. F., Hong, H. C., Huang, K. C., Hsu, S. P., Huang, T. C. & Hsia, S. M., Jan 1 2020, In: Journal of Pineal Research. 68, 1, p. e12620 e12620.

  Research output: Contribution to journal › Article › peer-review

  • Leiomyoma
  • Melatonin
  • Cell Death
  • Cell Proliferation
  • Myometrium
  3 Citations (Scopus)

• Melissa officinalis Extract Induces Apoptosis and Inhibits Migration in Human Colorectal Cancer Cells

  Kuo, T. T., Chang, H. Y., Chen, T. Y., Liu, B. C., Chen, H. Y., Hsiung, Y. C., Hsia, S. M., Chang, C. J. & Huang, T. C., 2020, (Accepted/In press) In: ACS Omega. 5, 49, p. 31792-31800 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cell death
  • Tea
  • Cells
  • Apoptosis
  • Polyketides

• Molybdenum doping effects for bismuth vanadate photocatalysts on electrochemical performances using the solution process

  Chen, Y. S., Lin, L. Y. & Lin, H. Y., Jan 1 2020, In: International Journal of Hydrogen Energy. 45, 1, p. 667-674 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Photocatalysts
  • vanadates
  • Bismuth
  • Molybdenum
  • Doping (additives)
  1 Citation (Scopus)

• Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs

  Yang, C. P., Yang, W. S., Wong, Y. H., Wang, K. H., Teng, Y. C., Chang, M. H., Liao, K. H., Nian, F. S., Chao, C. C., Tsai, J. W., Hwang, W. L., Lin, M. W., Tzeng, T. Y., Wang, P. N., Campbell, M., Chen, L. K., Tsai, T. F., Chang, P. C. & Kung, H. J., May 1 2020, In: Aging Cell. 19, 5, e13107.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Muscular Atrophy
  • Long Noncoding RNA
  • Skeletal Muscle Fibers
  • MicroRNAs
  • Exosomes
  2 Citations (Scopus)

• N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression

  Mehndiratta, S., Lin, M. H., Wu, Y. W., Chen, C. H., Wu, T. Y., Chuang, K. H., Chao, M. W., Chen, Y. Y., Pan, S. L., Chen, M. C. & Liou, J. P., Jan 1 2020, In: European Journal of Medicinal Chemistry. 185, p. 111725 111725.

  Research output: Contribution to journal › Article › peer-review

  • Anilides
  • HSP90 Heat-Shock Proteins
  • Histone Deacetylase Inhibitors
  • Histone Deacetylases
  • 3-(5-nitrofuryl)-7-(5-nitrofurfurylidene)-3,3a,4,5,6,7-hexahydro-2H-indazole
  16 Citations (Scopus)

• NDAT Targets PI3K-Mediated PD-L1 Upregulation to Reduce Proliferation in Gefitinib-Resistant Colorectal Cancer

  Huang, T. Y., Chang, T. C., Chin, Y. T., Pan, Y. S., Chang, W. J., Liu, F. C., Hastuti, E. D., Chiu, S. J., Wang, S. H., Changou, C. A., Li, Z. L., Chen, Y. R., Chu, H. R., Shih, Y. J., Cheng, R. H., Wu, A., Lin, H. Y., Wang, K., Whang-Peng, J., Mousa, S. A. & 1 others, Davis, P. J., Aug 3 2020, In: Cells. 9, 8

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • nano-diamino-tetrac
  • Gefitinib
  • Phosphatidylinositol 3-Kinases
  • Colorectal Neoplasms
  • Up-Regulation
  1 Citation (Scopus)

• Novel flexible solid-state pseudo-parallel pseudocapacitor with manganese oxide active material synthesized using electrodeposition

  Xu, S. Y., Lin, L. Y. & Lin, H. Y., Nov 30 2020, In: Journal of Alloys and Compounds. 843, 156017.

  Research output: Contribution to journal › Article › peer-review

  • manganese oxide
  • Manganese oxide
  • Electrodeposition
  • Supercapacitor
  • Electrodes
  4 Citations (Scopus)

• Overexpressed gene signature of EPH receptor A/B family in cancer patients-comprehensive analyses from the public high-throughput database

  Phan, N. N., Liu, S., Wang, C-Y., Hsu, H-P., Lai, M-D., Li, C-Y., Chen, C-F., Chiao, C-C., Yen, M-C., Sun, Z. & Jiang, J-Z., 2020, In: International Journal of Clinical and Experimental Pathology. 13, 5, p. 1220-1242 23 p.

  Research output: Contribution to journal › Article › peer-review

  • Erythropoietin
  • Hepatocellular Carcinoma
  • Databases
  • Genes
  • Neoplasms

• Overexpression of miR-21-5p in colorectal cancer cells promotes self-assembly of E-cadherin-dependent multicellular tumor spheroids

  Li, A. & Yang, P. M., Aug 1 2020, In: Tissue and Cell. 65, 101365.

  Research output: Contribution to journal › Article › peer-review

  • Cellular Spheroids
  • Cadherins
  • Colorectal Neoplasms
  • Cell Communication
  • Popular Culture
  1 Citation (Scopus)

• Platelet ATP, Thyroid Hormone Receptor on Integrin αvβ3 and Cancer Metastasis

  Davis, P. J., Mousa, S. A., Schechter, G. P. & Lin, H. Y., Feb 1 2020, In: Hormones and Cancer. 11, 1, p. 13-16 4 p.

  Research output: Contribution to journal › Review article › peer-review

  • Thyroid Hormone Receptors
  • Integrins
  • Blood Platelets
  • Adenosine Triphosphate
  • Neoplasm Metastasis
  1 Citation (Scopus)

• Preclinical investigation of ovatodiolide as a potential inhibitor of colon cancer stem cells via downregulating sphere-derived exosomal β-catenin/STAT3/miR-1246 cargoes

  Huang, Y-J., Huang, T. H., Yadav, V. K., Sumitra, M. R., Tzeng, D. T., Wei, P-L., Shih, J-W. & Wu, A. T., 2020, In: American Journal of Cancer Research. 10, 8, p. 2337-2354 18 p.

  Research output: Contribution to journal › Article › peer-review

  • ovatodiolide
  • Catenins
  • Exosomes
  • Neoplastic Stem Cells
  • Colonic Neoplasms

• Predicting malignancy: Subsolid nodules detected on LDCT in a surgical cohort of East Asian patients

  Wang, Y. H., Chen, C. F., Lin, Y. K., Chiang, C., Tzao, C. & Yen, Y., Aug 1 2020, In: Journal of Thoracic Disease. 12, 8, p. 4315-4326 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Adenocarcinoma
  • Tomography
  • Adenocarcinoma in Situ
  • Air
  • Neoplasms