Ph.D. Program for Cancer Molecular Biology and Drug Discovery

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output

2020
Open Access

Evaluation of machine learning methods to stroke outcome prediction using a nationwide disease registry

Lin, C. H., Hsu, K. C., Johnson, K. R., Fann, Y. C., Tsai, C. H., Sun, Y., Lien, L. M., Chang, W. L., Chen, P. L., Lin, C. L. & Hsu, C. Y., Jul 2020, In : Computer Methods and Programs in Biomedicine. 190, 105381.

Research output: Contribution to journalArticle

Knockdown of serine/threonine-protein kinase 24 promotes tumorigenesis and myeloid-derived suppressor cell expansion in an orthotopic immunocompetent gastric cancer animal model

Hsu, H. P., Wang, C. Y., Hsieh, P. Y., Fang, J. H. & Chen, Y. L., Jan 1 2020, In : Journal of Cancer. 11, 1, p. 213-228 16 p.

Research output: Contribution to journalArticle

Open Access

Long-term Proton Pump Inhibitor Administration Caused Physiological and Microbiota Changes in Rats

Yang, Y. C. S. H., Chang, H. W., Lin, I. H., Chien, L. N., Wu, M. J., Liu, Y. R., Chu, P. G., Xie, G., Dong, F., Jia, W., Chang, V. H. S. & Yen, Y., Dec 1 2020, In : Scientific Reports. 10, 1, 866.

Research output: Contribution to journalArticle

Open Access

Melatonin activates cell death programs for the suppression of uterine leiomyoma cell proliferation

Lin, P. H., Tung, Y. T., Chen, H. Y., Chiang, Y. F., Hong, H. C., Huang, K. C., Hsu, S. P., Huang, T. C. & Hsia, S. M., Jan 1 2020, In : Journal of Pineal Research. 68, 1, p. e12620 e12620.

Research output: Contribution to journalArticle

1 Citation (Scopus)

N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression

Mehndiratta, S., Lin, M. H., Wu, Y. W., Chen, C. H., Wu, T. Y., Chuang, K. H., Chao, M. W., Chen, Y. Y., Pan, S. L., Chen, M. C. & Liou, J. P., Jan 1 2020, In : European Journal of Medicinal Chemistry. 185, p. 111725 111725.

Research output: Contribution to journalArticle

1 Citation (Scopus)

NDAT suppresses pro-inflammatory gene expression to enhance resveratrol-induced anti-proliferation in oral cancer cells

Ho, Y., Wu, C. Y., Chin, Y. T., Li, Z. L., Pan, Y. S., Huang, T. Y., Su, P. Y., Lee, S. Y., Crawford, D. R., Su, K. W., Chiu, H. C., Shih, Y. J., Changou, C. A., Yang, Y. C. S. H., Whang-Peng, J., Chen, Y. R., Lin, H. Y., Mousa, S. A., Davis, P. J. & Wang, K., Feb 1 2020, In : Food and Chemical Toxicology. 136, p. 111092 111092.

Research output: Contribution to journalArticle

Sorafenib inhibits ribonucleotide reductase regulatory subunit M2 (RRM2) in hepatocellular carcinoma cells

Yang, P. M., Lin, L. S. & Liu, T. P., Jan 2020, In : Biomolecules. 10, 1, 117.

Research output: Contribution to journalArticle

Open Access
2019

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Action of Reverse T3 on Cancer Cells

Lin, H. Y., Tang, H. Y., Leinung, M., Mousa, S. A., Hercbergs, A. & Davis, P. J., Jan 1 2019, In : Endocrine Research.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Alternative splicing in human cancer cells is modulated by the amiloride derivative 3,5-diamino-6-chloro-N-(N-(2,6-dichlorobenzoyl)carbamimidoyl)pyrazine-2-carboxide

Lee, C. C., Chang, W. H., Chang, Y. S., Yang, J. M., Chang, C. S., Hsu, K. C., Chen, Y. T., Liu, T. Y., Chen, Y. C., Lin, S. Y., Wu, Y. C. & Chang, J. G., Jan 1 2019, In : Molecular Oncology. 13, 8, p. 1744-1762 19 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Androgen deprivation-induced ZBTB46-PTGS1 signaling promotes neuroendocrine differentiation of prostate cancer

Chen, W. Y., Zeng, T., Wen, Y. C., Yeh, H. L., Jiang, K. C., Chen, W. H., Zhang, Q., Huang, J. & Liu, Y. N., Jan 1 2019, In : Cancer Letters. 440-441, p. 35-46 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
Open Access
1 Citation (Scopus)
Open Access

Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivo

Hsieh, Y. L., Tu, H. J., Pan, S. L., Liou, J. P. & Yang, C. R., Jun 1 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 6, p. 992-1003 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Association of matrix Metalloproteinase-9 rs3918242 promoter genotypes with colorectal cancer risk

Wu, M. H., Tzeng, H. E., Wu, C. N., Yueh, T. C., Peng, Y. C., Tsai, C. H., Wang, Y. C., Ke, T. W., Pei, J. S., Chang, W. S., Tsai, C. W. & Bau, D. T., Jan 1 2019, In : Anticancer Research. 39, 12, p. 6523-6529 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Chicken-Derived Humanized Antibody Targeting a Novel Epitope F2pep of Fibroblast Growth Factor Receptor 2: Potential Cancer Therapeutic Agent

Tsai, K. C., Chang, C. D., Cheng, M. H., Lin, T. Y., Lo, Y. N., Yang, T. W., Chang, F. L., Chiang, C. W., Lee, Y. C. & Yen, Y., Jan 31 2019, In : ACS Omega. 4, 1, p. 2387-2397 11 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Comparison of the biological impact of UVA and UVB upon the skin with functional proteomics and immunohistochemistry

Wang, P. W., Hung, Y. C., Lin, T. Y., Fang, J. Y., Yang, P. M., Chen, M. H. & Pan, T. L., Dec 2019, In : Antioxidants. 8, 12, 569.

Research output: Contribution to journalArticle

Open Access

Dental Pulp Stem Cell Transplantation with 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside Accelerates Alveolar Bone Regeneration in Rats

Lin, C. Y., Kuo, P. J., Chin, Y. T., Weng, I. T., Lee, H. W., Huang, H. M., Lin, H. Y., Hsiung, C. N., Chan, Y. H. & Lee, S. Y., Apr 1 2019, In : Journal of Endodontics. 45, 4, p. 435-441 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Development and clinical applications of cancer immunotherapy against PD-1 signaling pathway

Wakabayashi, G., Lee, Y. C., Luh, F., Kuo, C. N., Chang, W. C. & Yen, Y., Dec 5 2019, In : Journal of Biomedical Science. 26, 1, 96.

Research output: Contribution to journalReview article

Open Access

Dietary flavonoids luteolin and quercetin inhibit migration and invasion of squamous carcinoma through reduction of src/stat3/s100a7 signaling

Fan, J. J., Hsu, W. H., Lee, K. H., Chen, K. C., Lin, C. W., Lee, Y. L. A., Ko, T. P., Lee, L. T., Lee, M. T., Chang, M. S. & Cheng, C. H., Nov 2019, In : Antioxidants. 8, 11, 557.

Research output: Contribution to journalArticle

Open Access

Differential effect of herbal tea extracts on free fatty acids-, ethanol- and acetaminophen-induced hepatotoxicity in FL83B hepatocytes

Chen, G. W., Chen, T. Y. & Yang, P. M., Jan 1 2019, (Accepted/In press) In : Drug and Chemical Toxicology.

Research output: Contribution to journalArticle

Does long-term use of antidiabetic drugs changes cancer risk?

Liu, Y. C., Nguyen, P. A., Humayun, A., Chien, S. C., Yang, H. C., Asdary, R. N., Syed-Abdul, S., Hsu, M. H., Moldovan, M., Yen, Y., Li, Y. C., Jian, W. S. & Iqbal, U., Oct 1 2019, In : Medicine (United States). 98, 40, p. e17461 e17461.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
Open Access
Open Access

Herbal medicines attenuate PD-L1 expression to induce anti-proliferation in obesity-related cancers

Yang, Y. C. S. H., Li, Z. L., Shih, Y. J., Bennett, J. A., Whang-Peng, J., Lin, H. Y., Davis, P. J. & Wang, K., Dec 2019, In : Nutrients. 11, 12, 2979.

Research output: Contribution to journalReview article

Open Access
1 Citation (Scopus)

Histone demethylase KDM4C stimulates the proliferation of prostate cancer cells via activation of AKT and c-Myc

Lin, C. Y., Wang, B. J., Chen, B. C., Tseng, J. C., Jiang, S. S., Tsai, K. K., Shen, Y. Y., Yuh, C. H., Sie, Z. L., Wang, W. C., Kung, H. J. & Chuu, C. P., Nov 13 2019, In : Cancers. 11, 11, 1785.

Research output: Contribution to journalArticle

Open Access

Host immune response to anti-cancer camptothecin conjugated cyclodextrin-based polymers

Chen, Y. F., Wang, Y. H., Lei, C. S., Changou, C. A., Davis, M. E. & Yen, Y., Oct 23 2019, In : Journal of Biomedical Science. 26, 1, 1 p.

Research output: Contribution to journalReview article

Open Access

Identification of two independent SUMO-interacting motifs in Fas-associated factor 1 (FAF1): Implications for mineralocorticoid receptor (MR)-mediated transcriptional regulation

Wang, C. H., Hung, P. W., Chiang, C. W., Lombès, M., Chen, C. H., Lee, K. H., Lo, Y. C., Wu, M. H., Chang, W. C. & Lin, D. Y., Aug 1 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 8, p. 1282-1297 16 p.

Research output: Contribution to journalArticle

Immune effector monocyte–neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer

Hagerling, C., Gonzalez, H., Salari, K., Wang, C. Y., Lin, C., Robles, I., van Gogh, M., Dejmek, A., Jirström, K. & Werb, Z., Oct 22 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 43, p. 21704-21714 11 p.

Research output: Contribution to journalArticle

Open Access
Open Access

In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer Cells

Chen, J. C., Hsieh, Y. Y., Lo, H. L., Li, A., Chou, C. J. & Yang, P. M., Sep 9 2019, In : Biomolecules. 9, 9

Research output: Contribution to journalArticle

Open Access

KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC

Wang, H. J., Pochampalli, M., Wang, L. Y., Zou, J. X., Li, P. S., Hsu, S. C., Wang, B. J., Huang, S. H., Yang, P., Yang, J. C., Chu, C. Y., Hsieh, C. L., Sung, S. Y., Li, C. F., Tepper, C. G., Ann, D. K., Gao, A. C., Evans, C. P., Izumiya, Y., Chuu, C. P. & 3 others, Wang, W. C., Chen, H. W. & Kung, H. J., Jan 3 2019, In : Oncogene. 38, 1, p. 17-32

Research output: Contribution to journalArticle

9 Citations (Scopus)

Leptin-derived peptides block leptin-induced proliferation by reducing expression of pro-inflammatory genes in hepatocellular carcinoma cells

Ho, Y., Wang, S. H., Chen, Y. R., Li, Z. L., Chin, Y. T., Yang, Y. C. S. H., Wu, Y. H., Su, K. W., Chu, H. R., Chiu, H. C., Crawford, D. R., Shih, Y. J., Grasso, P., Tang, H. Y., Lin, H. Y., Davis, P. J., Whang-Peng, J. & Wang, K., Nov 1 2019, In : Food and Chemical Toxicology. 133, p. 110808 110808.

Research output: Contribution to journalArticle

Leukemia Inhibitory Factor Promotes Castration-resistant Prostate Cancer and Neuroendocrine Differentiation by Activated ZBTB46

Liu, Y-N., Niu, S., Chen, W-Y., Zhang, Q., Tao, Y., Chen, W-H., Jiang, K-C., Chen, X., Shi, H., Liu, A., Li, J., Li, Y., Lee, Y-C., Zhang, X. & Huang, J., Apr 8 2019, In : Clinical cancer research : an official journal of the American Association for Cancer Research.

Research output: Contribution to journalArticle

2 Citations (Scopus)

LncRNA NORAD is repressed by the YAP pathway and suppresses lung and breast cancer metastasis by sequestering S100P

Tan, B. S., Yang, M. C., Singh, S., Chou, Y. C., Chen, H. Y., Wang, M. Y., Wang, Y. C. & Chen, R. H., Jan 1 2019, In : Oncogene.

Research output: Contribution to journalArticle

6 Citations (Scopus)

miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2

Chen, H. Y., Lang, Y. D., Lin, H. N., Liu, Y. R., Liao, C. C., Nana, A. W., Yen, Y. & Chen, R. H., Dec 1 2019, In : Scientific Reports. 9, 1, 9687.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy

Owyong, M., Chou, J., van den Bijgaart, R. J. E., Kong, N., Efe, G., Maynard, C., Talmi-Frank, D., Solomonov, I., Koopman, C., Hadler-Olsen, E., Headley, M., Lin, C., Wang, C. Y., Sagi, I., Werb, Z. & Plaks, V., Jan 1 2019, In : Life Science Alliance. 2, 6, e201800226.

Research output: Contribution to journalArticle

Open Access

MPT0G413, A novel HDAC6-selective inhibitor, and bortezomib synergistically exert anti-tumor activity in multiple myeloma cells

Huang, F. I., Wu, Y. W., Sung, T. Y., Liou, J. P., Lin, M. H., Pan, S. L. & Yang, C. R., Jan 1 2019, In : Frontiers in Oncology. 9, APR, p. 249 249.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Mutation of the PTCH1 gene predicts recurrence of breast cancer

Wang, C. Y., Chang, Y. C., Kuo, Y. L., Lee, K. T., Chen, P. S., Cheung, C. H. A., Chang, C. P., Phan, N. N., Shen, M. R. & Hsu, H. P., Dec 1 2019, In : Scientific Reports. 9, 1, 16359.

Research output: Contribution to journalArticle

Open Access

Natural Antioxidant Resveratrol Suppresses Uterine Fibroid Cell Growth and Extracellular Matrix Formation In Vitro and In Vivo

Chen, H-Y., Lin, P-H., Shih, Y-H., Wang, K-L., Hong, Y-H., Shieh, T-M., Huang, T-C. & Hsia, S-M., Apr 12 2019, In : Antioxidants. 8, 4

Research output: Contribution to journalArticle

4 Citations (Scopus)

New paradigm of functional regulation by DNA mimic proteins: Recent updates

Wang, H. C., Chou, C. C., Hsu, K. C., Lee, C. H. & Wang, A. H. J., May 1 2019, In : IUBMB Life. 71, 5, p. 539-548 10 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Novel Common Genetic Susceptibility Loci for Colorectal Cancer

Schmit, S. L., Edlund, C. K., Schumacher, F. R., Gong, J., Harrison, T. A., Huyghe, J. R., Qu, C., Melas, M., Van Den Berg, D. J., Wang, H., Tring, S., Plummer, S. J., Albanes, D., Alonso, M. H., Amos, C. I., Anton, K., Aragaki, A. K., Arndt, V., Barry, E. L., Berndt, S. I. & 30 others, Bezieau, S., Bien, S., Bloomer, A., Boehm, J., Boutron-Ruault, M. C., Brenner, H., Brezina, S., Buchanan, D. D., Butterbach, K., Caan, B. J., Campbell, P. T., Carlson, C. S., Castelao, J. E., Chan, A. T., Chang-Claude, J., Chanock, S. J., Cheng, I., Cheng, Y. W., Chin, L. S., Church, J. M., Church, T., Coetzee, G. A., Cotterchio, M., Cruz Correa, M., Curtis, K. R., Duggan, D., Lin, Y., Liu, Y. R., Yen, Y. & Hsu, L., Feb 1 2019, In : Journal of the National Cancer Institute. 111, 2, p. 146-157 12 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)