Research Output per year
Research Output
2020
A site-moiety map and virtual screening approach for discovery of novel 5-LOX inhibitors
Hsu, K. C., HuangFu, W. C., Lin, T. E., Chao, M. W., Sung, T. Y., Chen, Y. Y., Pan, S. L., Lee, J. C., Tzou, S. C., Sun, C. M. & Yang, J. M., Dec 1 2020, In : Scientific Reports. 10, 1, 10510.Research output: Contribution to journal › Article
Open Access
Astragalus membranaceus-Derived Anti-Programmed Death-1 Monoclonal Antibodies with Immunomodulatory Therapeutic Effects against Tumors
Chang, F. L., Tsai, K. C., Lin, T. Y., Yang, T. W., Lo, Y. N., Chen, W. C., Chang, J. H., Lu, M. K., Chiou, C. T., Chen, P. H., Yen, Y., Pan, S. L. & Lee, Y. C., Jan 1 2020, In : BioMed Research International. 2020, 3415471.Research output: Contribution to journal › Article
Open Access
3
Citations
(Scopus)
CC12 induces apoptotic cell death and cell cycle arrest in human glioblastoma cell lines and mouse xenograft model
Fann, L. Y., Shih, J. H., Tseng, J. H., Huang, H. S. & Hsiao, S. H., Apr 2020, In : Molecules. 25, 8, 25081793.Research output: Contribution to journal › Article
Open Access
Chondroitin sulfate proteoglycan 4 regulates zebrafish body axis organization via Wnt/ planar cell polarity pathway
Lee, Y. H., Kawakami, K., HuangFu, W. C. & Liu, I. H., Jan 1 2020, In : PLoS ONE. 15, 4, e0230943.Research output: Contribution to journal › Article
Open Access
Clinical-grade cryopreserved doxorubicin-loaded platelets: Role of cancer cells and platelet extracellular vesicles activation loop
Wu, Y. W., Huang, C. C., Changou, C. A., Lu, L. S., Goubran, H. & Burnouf, T., Mar 23 2020, In : Journal of Biomedical Science. 27, 1, p. 45 45.Research output: Contribution to journal › Article
Open Access
Correction: Role of integrin-linked kinase in regulating the protein stability of the MUC1-C oncoprotein in pancreatic cancer cells (Oncogenesis, (2017), 6, 7, (e359), 10.1038/oncsis.2017.61)
Huang, H. L., Wu, H. Y., Chu, P. C., Lai, I. L., Huang, P. H., Kulp, S. K., Pan, S. L., Teng, C. M. & Chen, C. S., Feb 1 2020, In : Oncogenesis. 9, 2, 27.Research output: Contribution to journal › Comment/debate
Open Access
Corrigendum to: TW-01, a piperazinedione-derived compound, inhibits Ras-mediated cell proliferation and angioplasty-induced vascular restenosis “Toxicol Appl Pharmacol. 2016;305:194–202” (Toxicology and Applied Pharmacology (2016) 305 (194–202)(S0041008X16301478)(10.1016/j.taap.2016.06.013))
Lin, C. F., Huang, H. L., Peng, C. Y., Lee, Y. C., Wang, H. P., Teng, C. M. & Pan, S. L., Jan 15 2020, In : Toxicology and Applied Pharmacology. 387, 114858.Research output: Contribution to journal › Comment/debate
Open Access
Corrigendum to “1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma” [Eur. J. Med. Chem. 140 (2017) 84–91](S0223523417306931)(10.1016/j.ejmech.2017.09.011)
Liu, Y. M., HuangFu, W. C., Huang, H. L., Wu, W. C., Chen, Y. L., Yen, Y., Huang, H. L., Nien, C. Y., Lai, M. J., Pan, S. L. & Liou, J. P., Sep 15 2020, In : European Journal of Medicinal Chemistry. 202, 112633.Research output: Contribution to journal › Comment/debate
Open Access
Corrigendum to“Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo”[Eur. J. Med. Chem. 190 (2020 Mar 15) 112086] (European Journal of Medicinal Chemistry (2020) 190, (S0223523420300532), (10.1016/j.ejmech.2020.112086))
Ojha, R., Nepali, K., Chen, C. H., Chuang, K. H., Wu, T. Y., Lin, T. E., Hsu, K. C., Chao, M. W., Lai, M. J., Lin, M. H., Huang, H. L., Chang, C. D., Pan, S. L., Chen, M. C. & Liou, J. P., Sep 1 2020, In : European Journal of Medicinal Chemistry. 201, 112404.Research output: Contribution to journal › Comment/debate
Corrigendum to “N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression”[Eur. J. Med. Chem. 2020 Jan 1;185:111725] (European Journal of Medicinal Chemistry (2020) 185, (S0223523419308773), (10.1016/j.ejmech.2019.111725))
Mehndiratta, S., Lin, M. H., Wu, Y. W., Chen, C. H., Wu, T. Y., Chuang, K. H., Chao, M. W., Chen, Y. Y., Pan, S. L., Chen, M. C. & Liou, J. P., Aug 1 2020, In : European Journal of Medicinal Chemistry. 199, 112406.Research output: Contribution to journal › Comment/debate
Open Access
Dicoumarol suppresses HMGA2-mediated oncogenic capacities and inhibits cell proliferation by inducing apoptosis in colon cancer
Chen, C. H., Hsieh, Y. C., Yang, P. M., Liu, Y. R. & Cho, E. C., 2020, In : Biochemical and Biophysical Research Communications.Research output: Contribution to journal › Article
Gene signatures and potential therapeutic targets of amino acid metabolism in estrogen receptor-positive breast cancer
Wang, C-Y., Chiao, C-C., Phan, N. N., Li, C-Y., Sun, Z-D., Jiang, J-Z., Hung, J-H., Chen, Y-L., Yen, M-C., Weng, T-Y., Chen, W-C., Hsu, H-P. & Lai, M-D., 2020, In : American Journal of Cancer Research. 10, 1, p. 95-113 19 p.Research output: Contribution to journal › Article
Gene signatures of SARS-CoV/SARS-CoV-2-infected ferret lungs in short- and long-term models
Liu, H. L., Yeh, I. J., Phan, N. N., Wu, Y. H., Yen, M. C., Hung, J. H., Chiao, C. C., Chen, C. F., Sun, Z., Jiang, J. Z., Hsu, H. P., Wang, C. Y. & Lai, M. D., Nov 2020, In : Infection, Genetics and Evolution. 85, 104438.Research output: Contribution to journal › Article
1
Citation
(Scopus)
Identification of the Effects of Aspirin and Sulindac Sulfide on the Inhibition of HMGA2-Mediated Oncogenic Capacities in Colorectal Cancer
Ekanem, T. I., Tsai, W. L., Lin, Y. H., Tan, W. Q., Chang, H. Y., Huang, T. C., Chen, H. Y. & Lee, K. H., Sep 2020, In : Molecules. 25, 17, 3826.Research output: Contribution to journal › Article
Open Access
Increased expression of secreted frizzled related protein 1 (SFRP1) predicts ampullary adenocarcinoma recurrence
Cheng, L. C., Chao, Y. J., Overman, M. J., Wang, C. Y., Phan, N. N., Chen, Y. L., Wang, T. W., Hsu, H. P., Shan, Y. S. & Lai, M. D., Dec 1 2020, In : Scientific Reports. 10, 1, 13255.Research output: Contribution to journal › Article
Open Access
Investigating the potential effects of selective histone deacetylase 6 inhibitor ACY1215 on infarct size in rats with cardiac ischemia-reperfusion injury
Lin, C. F., Hsu, K. C., Huangfu, W. C., Lin, T. E., Huang, H. L. & Pan, S. L., Mar 12 2020, In : BMC Pharmacology and Toxicology. 21, 1, p. 21 21.Research output: Contribution to journal › Article
Open Access
Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo
Ojha, R., Nepali, K., Chen, C. H., Chuang, K. H., Wu, T. Y., Lin, T. E., Hsu, K. C., Chao, M. W., Lai, M. J., Lin, M. H., Huang, H. L., Chang, C. D., Pan, S. L., Chen, M. C. & Liou, J. P., Mar 15 2020, In : European Journal of Medicinal Chemistry. 190, 112086.Research output: Contribution to journal › Article
2
Citations
(Scopus)
Knockdown of serine/threonine-protein kinase 24 promotes tumorigenesis and myeloid-derived suppressor cell expansion in an orthotopic immunocompetent gastric cancer animal model
Hsu, H. P., Wang, C. Y., Hsieh, P. Y., Fang, J. H. & Chen, Y. L., Jan 1 2020, In : Journal of Cancer. 11, 1, p. 213-228 16 p.Research output: Contribution to journal › Article
Open Access
Long-term Proton Pump Inhibitor Administration Caused Physiological and Microbiota Changes in Rats
Yang, Y. C. S. H., Chang, H. W., Lin, I. H., Chien, L. N., Wu, M. J., Liu, Y. R., Chu, P. G., Xie, G., Dong, F., Jia, W., Chang, V. H. S. & Yen, Y., Dec 1 2020, In : Scientific Reports. 10, 1, 866.Research output: Contribution to journal › Article
Open Access
1
Citation
(Scopus)
Melatonin activates cell death programs for the suppression of uterine leiomyoma cell proliferation
Lin, P. H., Tung, Y. T., Chen, H. Y., Chiang, Y. F., Hong, H. C., Huang, K. C., Hsu, S. P., Huang, T. C. & Hsia, S. M., Jan 1 2020, In : Journal of Pineal Research. 68, 1, p. e12620 e12620.Research output: Contribution to journal › Article
3
Citations
(Scopus)
Molybdenum doping effects for bismuth vanadate photocatalysts on electrochemical performances using the solution process
Chen, Y. S., Lin, L. Y. & Lin, H. Y., Jan 1 2020, In : International Journal of Hydrogen Energy. 45, 1, p. 667-674 8 p.Research output: Contribution to journal › Article
Open Access
Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs
Yang, C. P., Yang, W. S., Wong, Y. H., Wang, K. H., Teng, Y. C., Chang, M. H., Liao, K. H., Nian, F. S., Chao, C. C., Tsai, J. W., Hwang, W. L., Lin, M. W., Tzeng, T. Y., Wang, P. N., Campbell, M., Chen, L. K., Tsai, T. F., Chang, P. C. & Kung, H. J., May 1 2020, In : Aging Cell. 19, 5, e13107.Research output: Contribution to journal › Article
Open Access
N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression
Mehndiratta, S., Lin, M. H., Wu, Y. W., Chen, C. H., Wu, T. Y., Chuang, K. H., Chao, M. W., Chen, Y. Y., Pan, S. L., Chen, M. C. & Liou, J. P., Jan 1 2020, In : European Journal of Medicinal Chemistry. 185, p. 111725 111725.Research output: Contribution to journal › Article
9
Citations
(Scopus)
Novel flexible solid-state pseudo-parallel pseudocapacitor with manganese oxide active material synthesized using electrodeposition
Xu, S. Y., Lin, L. Y. & Lin, H. Y., Nov 30 2020, In : Journal of Alloys and Compounds. 843, 156017.Research output: Contribution to journal › Article
1
Citation
(Scopus)
Overexpression of miR-21-5p in colorectal cancer cells promotes self-assembly of E-cadherin-dependent multicellular tumor spheroids
Li, A. & Yang, P. M., Aug 2020, In : Tissue and Cell. 65, 101365.Research output: Contribution to journal › Article
Platelet ATP, Thyroid Hormone Receptor on Integrin αvβ3 and Cancer Metastasis
Davis, P. J., Mousa, S. A., Schechter, G. P. & Lin, H. Y., Feb 1 2020, In : Hormones and Cancer. 11, 1, p. 13-16 4 p.Research output: Contribution to journal › Review article
Purine/purine isoster based scaffolds as new derivatives of benzamide class of HDAC inhibitors
Nepali, K., Chang, T. Y., Lai, M. J., Hsu, K. C., Yen, Y., Lin, T. E., Lee, S. B. & Liou, J. P., Jun 15 2020, In : European Journal of Medicinal Chemistry. 196, 112291.Research output: Contribution to journal › Article
1
Citation
(Scopus)
Ras and Wnt interaction contribute in prostate cancer bone metastasis
Lin, S. R., Mokgautsi, N. & Liu, Y. N., May 2020, In : Molecules. 25, 10, 2380.Research output: Contribution to journal › Review article
Open Access
Sequential interferon β-cisplatin treatment enhances the surface exposure of calreticulin in cancer cells via an interferon regulatory factor 1-dependent manner
Yang, P. M., Hsieh, Y. Y., Du, J. L., Yen, S. C. & Hung, C. F., Apr 2020, In : Biomolecules. 10, 4, 643.Research output: Contribution to journal › Article
Open Access
Signaling in and out: Long-noncoding RNAs in tumor hypoxia
Kuo, T. C., Kung, H. J. & Shih, J. W., May 5 2020, In : Journal of Biomedical Science. 27, 1, 59.Research output: Contribution to journal › Review article
Open Access
Sorafenib inhibits ribonucleotide reductase regulatory subunit M2 (RRM2) in hepatocellular carcinoma cells
Yang, P. M., Lin, L. S. & Liu, T. P., Jan 2020, In : Biomolecules. 10, 1, 117.Research output: Contribution to journal › Article
Open Access
1
Citation
(Scopus)
Structural insight into the differential interactions between the DNA mimic protein SAUGI and two gamma herpesvirus uracil-DNA glycosylases
Liao, Y. T., Lin, S. J., Ko, T. P., Liu, C. Y., Hsu, K. C. & Wang, H. C., Oct 1 2020, In : International Journal of Biological Macromolecules. 160, p. 903-914 12 p.Research output: Contribution to journal › Article
Surgical outcomes of robotic transanal minimally invasive surgery for selected rectal neoplasms: A single-hospital experience
Huang, Y. J., Huang, Y. M., Wang, W. L., Tong, Y. S., Hsu, W. & Wei, P. L., Jan 2020, In : Asian Journal of Surgery. 43, 1, p. 290-296 7 p.Research output: Contribution to journal › Article
Open Access
Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease
Tseng, H. J., Lin, M. H., Shiao, Y. J., Yang, Y. C., Chu, J. C., Chen, C. Y., Chen, Y. Y., Lin, T. E., Su, C. J., Pan, S. L., Chen, L. C., Wang, C. Y., Hsu, K. C. & Huang, W. J., Apr 15 2020, In : European Journal of Medicinal Chemistry. 192, p. 112193 112193.Research output: Contribution to journal › Article
1
Citation
(Scopus)
Temporal expression patterns of distinct cytokines and M1/M2 macrophage polarization regulate rheumatoid arthritis progression
Kung, C. C., Dai, S. P., Chiang, H., Huang, H. S. & Sun, W. H., Jan 1 2020, (Accepted/In press) In : Molecular Biology Reports.Research output: Contribution to journal › Article
Topical application of Heparanase-1 facilitates bone remodeling during the healing of bone defects in a mouse model
Chiu, P-Y., HuangFu, W-C., Liu, I-H. & Chang, Y-P., Jan 21 2020, In : Journal of the Chinese Medical Association : JCMA.Research output: Contribution to journal › Article
2
Citations
(Scopus)
Tumor-infiltrating leukocytes suppress local inflammation via interleukin-1 receptor antagonist in a syngeneic prostate cancer model
Fan, Y. C., Chen, W. Y., Lee, K. D. & Tsai, Y. C., Apr 2020, In : Biology. 9, 4, 67.Research output: Contribution to journal › Article
Open Access
Two first-in-human studies of xentuzumab, a humanised insulin-like growth factor (IGF)-neutralising antibody, in patients with advanced solid tumours
de Bono, J., Lin, C. C., Chen, L. T., Corral, J., Michalarea, V., Rihawi, K., Ong, M., Lee, J. H., Hsu, C. H., Yang, J. C. H., Shiah, H. S., Yen, C. J., Anthoney, A., Jove, M., Buschke, S., Fuertig, R., Schmid, U., Goeldner, R. G., Strelkowa, N., Huang, D. C. L. & 3 others, , Apr 28 2020, In : British Journal of Cancer. 122, 9, p. 1324-1332 9 p.Research output: Contribution to journal › Article
Open Access
Upregulation of protein synthesis and proteasome degradation confers sensitivity to proteasome inhibitor bortezomib in myc-atypical teratoid/rhabdoid tumors
Tran, H. M., Wu, K. S., Sung, S. Y., Changou, C. A., Hsieh, T. H., Liu, Y. R., Liu, Y. L., Tsai, M. L., Lee, H. L., Hsieh, K. L. C., Huang, W. C., Liang, M. L., Chen, H. H., Lee, Y. Y., Lin, S. C., Ho, D. M. T., Chang, F. C., Chao, M. E., Chen, W., Chu, S. S. & 4 others, , Mar 22 2020, In : Cancers. 12, 3, 752.Research output: Contribution to journal › Article
Open Access
γ-Mangostin isolated from Garcinia mangostana L. suppresses inflammation and alleviates symptoms of osteoarthritis via modulating miR-124-3p/IL-6/NF-κB signaling
Chiu, Y-S., Wu, J-L., Yeh, C-T., Yadav, V. K., Huang, H-S. & Wang, L-S., Apr 16 2020, In : Aging. 12, 8, p. 6630-6643 14 p.Research output: Contribution to journal › Article
2019
1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase
Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.Research output: Contribution to journal › Article
6
Citations
(Scopus)
Action of Reverse T3 on Cancer Cells
Lin, H. Y., Tang, H. Y., Leinung, M., Mousa, S. A., Hercbergs, A. & Davis, P. J., Jan 1 2019, In : Endocrine Research.Research output: Contribution to journal › Article
3
Citations
(Scopus)
Alternative splicing in human cancer cells is modulated by the amiloride derivative 3,5-diamino-6-chloro-N-(N-(2,6-dichlorobenzoyl)carbamimidoyl)pyrazine-2-carboxide
Lee, C. C., Chang, W. H., Chang, Y. S., Yang, J. M., Chang, C. S., Hsu, K. C., Chen, Y. T., Liu, T. Y., Chen, Y. C., Lin, S. Y., Wu, Y. C. & Chang, J. G., Jan 1 2019, In : Molecular Oncology. 13, 8, p. 1744-1762 19 p.Research output: Contribution to journal › Article
Open Access
Amide-tethered quinoline-resorcinol conjugates as a new class of HSP90 inhibitors suppressing the growth of prostate cancer cells
Nepali, K., Lin, M. H., Chao, M. W., Peng, S. J., Hsu, K. C., Eight Lin, T., Chen, M. C., Lai, M. J., Pan, S. L. & Liou, J. P., Oct 1 2019, In : Bioorganic Chemistry. 91, 103119.Research output: Contribution to journal › Article
2
Citations
(Scopus)
Androgen deprivation-induced ZBTB46-PTGS1 signaling promotes neuroendocrine differentiation of prostate cancer
Chen, W. Y., Zeng, T., Wen, Y. C., Yeh, H. L., Jiang, K. C., Chen, W. H., Zhang, Q., Huang, J. & Liu, Y. N., Jan 1 2019, In : Cancer Letters. 440-441, p. 35-46 12 p.Research output: Contribution to journal › Article
4
Citations
(Scopus)
An integrated bioinformatics analysis repurposes an antihelminthic drug niclosamide for treating hmga2-overexpressing human colorectal cancer
Leung, S. W., Chou, C. J., Huang, T. C. & Yang, P. M., Oct 2019, In : Cancers. 11, 10, 1482.Research output: Contribution to journal › Article
Open Access
3
Citations
(Scopus)
A novel multi-target small molecule, LCC-09, inhibits stemness and therapy-resistant phenotypes of glioblastoma cells by increasing MIR-34a and deregulating the DRD4/AKT/MTOR signaling axis
Wen, Y. T., Wu, A. T., Bamodu, O. A., Wei, L., Lin, C. M., Yen, Y., Chao, T. Y., Mukhopadhyay, D., Hsiao, M. & Huang, H. S., Oct 1 2019, In : Cancers. 11, 10, 1442.Research output: Contribution to journal › Article
Open Access
2
Citations
(Scopus)
Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivo
Hsieh, Y. L., Tu, H. J., Pan, S. L., Liou, J. P. & Yang, C. R., Jun 1 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 6, p. 992-1003 12 p.Research output: Contribution to journal › Article
7
Citations
(Scopus)
Association of matrix Metalloproteinase-9 rs3918242 promoter genotypes with colorectal cancer risk
Wu, M. H., Tzeng, H. E., Wu, C. N., Yueh, T. C., Peng, Y. C., Tsai, C. H., Wang, Y. C., Ke, T. W., Pei, J. S., Chang, W. S., Tsai, C. W. & Bau, D. T., Jan 1 2019, In : Anticancer Research. 39, 12, p. 6523-6529 7 p.Research output: Contribution to journal › Article
4
Citations
(Scopus)
Chicken-Derived Humanized Antibody Targeting a Novel Epitope F2pep of Fibroblast Growth Factor Receptor 2: Potential Cancer Therapeutic Agent
Tsai, K. C., Chang, C. D., Cheng, M. H., Lin, T. Y., Lo, Y. N., Yang, T. W., Chang, F. L., Chiang, C. W., Lee, Y. C. & Yen, Y., Jan 31 2019, In : ACS Omega. 4, 1, p. 2387-2397 11 p.Research output: Contribution to journal › Article
Open Access
1
Citation
(Scopus)