Ph.D. Program for Cancer Molecular Biology and Drug Discovery

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output 1996 2019

2019
4 Citations (Scopus)

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journal › Article

Benzamides
Histone Deacetylases
Tubulin
Heterografts
Inhibitory Concentration 50
1 Citation (Scopus)

Action of Reverse T3 on Cancer Cells

Lin, H. Y., Tang, H. Y., Leinung, M., Mousa, S. A., Hercbergs, A. & Davis, P. J., Jan 1 2019, In : Endocrine Research.

Research output: Contribution to journal › Article

Integrins
Thyronines
Thyroid Hormone Receptors
Neoplasms
Glioblastoma

Alternative splicing in human cancer cells is modulated by the amiloride derivative 3,5-diamino-6-chloro-N-(N-(2,6-dichlorobenzoyl)carbamimidoyl)pyrazine-2-carboxide

Lee, C. C., Chang, W. H., Chang, Y. S., Yang, J. M., Chang, C. S., Hsu, K. C., Chen, Y. T., Liu, T. Y., Chen, Y. C., Lin, S. Y., Wu, Y. C. & Chang, J. G., Jan 1 2019, In : Molecular Oncology.

Research output: Contribution to journal › Article

Open Access
Pyrazines
Amiloride
Alternative Splicing
Neoplasms
RNA Sequence Analysis

Amide-tethered quinoline-resorcinol conjugates as a new class of HSP90 inhibitors suppressing the growth of prostate cancer cells

Nepali, K., Lin, M. H., Chao, M. W., Peng, S. J., Hsu, K. C., Eight Lin, T., Chen, M. C., Lai, M. J., Pan, S. L. & Liou, J. P., Oct 1 2019, In : Bioorganic Chemistry. 91, 103119.

Research output: Contribution to journal › Article

Growth Inhibitors
Amides
Prostatic Neoplasms
Cells
Lead compounds
3 Citations (Scopus)

Androgen deprivation-induced ZBTB46-PTGS1 signaling promotes neuroendocrine differentiation of prostate cancer

Chen, W. Y., Zeng, T., Wen, Y. C., Yeh, H. L., Jiang, K. C., Chen, W. H., Zhang, Q., Huang, J. & Liu, Y. N., Jan 1 2019, In : Cancer Letters. 440-441, p. 35-46 12 p.

Research output: Contribution to journal › Article

Prostaglandin-Endoperoxide Synthases
Androgens
Prostatic Neoplasms
Cyclooxygenase Inhibitors
Androgen Receptors

A novel multi-target small molecule, LCC-09, inhibits stemness and therapy-resistant phenotypes of glioblastoma cells by increasing MIR-34a and deregulating the DRD4/AKT/MTOR signaling axis

Wen, Y. T., Wu, A. T., Bamodu, O. A., Wei, L., Lin, C. M., Yen, Y., Chao, T. Y., Mukhopadhyay, D., Hsiao, M. & Huang, H. S., Oct 1 2019, In : Cancers. 11, 10, 1442.

Research output: Contribution to journal › Article

Open Access
temozolomide
Glioblastoma
Phenotype
Glioma
Stem Cells
2 Citations (Scopus)

Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivo

Hsieh, Y. L., Tu, H. J., Pan, S. L., Liou, J. P. & Yang, C. R., Jun 1 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 6, p. 992-1003 12 p.

Research output: Contribution to journal › Article

Triple Negative Breast Neoplasms
Histone Deacetylase Inhibitors
Breast Neoplasms
Histone Deacetylases
Acetylation

Chicken-Derived Humanized Antibody Targeting a Novel Epitope F2pep of Fibroblast Growth Factor Receptor 2: Potential Cancer Therapeutic Agent

Tsai, K. C., Chang, C. D., Cheng, M. H., Lin, T. Y., Lo, Y. N., Yang, T. W., Chang, F. L., Chiang, C. W., Lee, Y. C. & Yen, Y., Jan 31 2019, In : ACS Omega. 4, 1, p. 2387-2397 11 p.

Research output: Contribution to journal › Article

Open Access
Receptor, Fibroblast Growth Factor, Type 2
Epitopes
Antibodies, Monoclonal, Humanized
Fibroblast Growth Factor Receptors
Fibroblasts

Corrigendum to “Comparative analysis of novel autoantibody isotypes against citrullinatedinter-alpha-trypsin inhibitor heavy chain 3 (ITIH3) 542–556 peptide in serum from Taiwanese females with rheumatoid arthritis, primary Sjögren's syndrome and secondary Sjögren's syndrome in rheumatoid arthritis” [J Proteomics 141: (2016) 1–11](S1874391916300860)(10.1016/j.jprot.2016.03.031)

Liao, C. C., Chou, P. L., Cheng, C. W., Chang, Y. S., Chi, W. M., Tsai, K. L., Chen, W. J., Kung, T. S., Tai, C. C., Lee, K. W., Chen, Y. C. & Lin, C. Y., Mar 1 2019, In : Journal of Proteomics. 194, p. 227 1 p.

Research output: Contribution to journal › Comment/debate

Immunology
Allergies
Trypsin Inhibitors
Rheumatology
Internal Medicine

Dental Pulp Stem Cell Transplantation with 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside Accelerates Alveolar Bone Regeneration in Rats

Lin, C. Y., Kuo, P. J., Chin, Y. T., Weng, I. T., Lee, H. W., Huang, H. M., Lin, H. Y., Hsiung, C. N., Chan, Y. H. & Lee, S. Y., Apr 1 2019, In : Journal of Endodontics. 45, 4, p. 435-441 7 p.

Research output: Contribution to journal › Article

Dental Pulp
Bone Regeneration
Stem Cell Transplantation
Stem Cells
Osteogenesis

Does long-term use of antidiabetic drugs changes cancer risk?

Liu, Y. C., Nguyen, P. A., Humayun, A., Chien, S. C., Yang, H. C., Asdary, R. N., Syed-Abdul, S., Hsu, M. H., Moldovan, M., Yen, Y., Li, Y. C., Jian, W. S. & Iqbal, U., Oct 1 2019, In : Medicine (United States). 98, 40, e17461.

Research output: Contribution to journal › Article

Open Access
Hypoglycemic Agents
pioglitazone
Neoplasms
Odds Ratio
Confidence Intervals

E2f1 regulates the induction of promyelocytic leukemia zinc finger transcription in neuronal differentiation of pluripotent P19 embryonal carcinoma cells

Lin, H. C., Ko, C. Y., Lee, K. H., Chen, I. H., Kao, T. J., Chang, W. C., Hsu, T. I. & Lee, Y. C., May 7 2019, In : Biochemical and Biophysical Research Communications. 512, 3, p. 629-634 6 p.

Research output: Contribution to journal › Article

Embryonal Carcinoma Stem Cells
Neural Stem Cells
Zinc Fingers
Transcription
Zinc

Glycidamide promotes the growth and migratory ability of prostate cancer cells by changing the protein expression of cell cycle regulators and epithelial-to-mesenchymal transition (EMT)- associated proteins with prognostic relevance

Ekanem, T. I., Huang, C. C., Wu, M. H., Lin, D. Y., Lai, W. F. T. & Lee, K. H., May 1 2019, In : International Journal of Molecular Sciences. 20, 9, 2199.

Research output: Contribution to journal › Article

Open Access
Cell Cycle Proteins
Epithelial-Mesenchymal Transition
regulators
Prostatic Neoplasms
genes

Host immune response to anti-cancer camptothecin conjugated cyclodextrin-based polymers

Chen, Y. F., Wang, Y. H., Lei, C. S., Changou, C. A., Davis, M. E. & Yen, Y., Oct 23 2019, In : Journal of Biomedical Science. 26, 1, 1 p.

Research output: Contribution to journal › Review article

Open Access
Camptothecin
Cyclodextrins
Polymers
Neoplasms
Nanoparticles

Identification of two independent SUMO-interacting motifs in Fas-associated factor 1 (FAF1): Implications for mineralocorticoid receptor (MR)-mediated transcriptional regulation

Wang, C. H., Hung, P. W., Chiang, C. W., Lombès, M., Chen, C. H., Lee, K. H., Lo, Y. C., Wu, M. H., Chang, W. C. & Lin, D. Y., Aug 1 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 8, p. 1282-1297 16 p.

Research output: Contribution to journal › Article

Mineralocorticoid Receptors
Ubiquitin
Catenins
Aldosterone
Transcriptional Activation

Immune effector monocyte–neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer

Hagerling, C., Gonzalez, H., Salari, K., Wang, C. Y., Lin, C., Robles, I., van Gogh, M., Dejmek, A., Jirström, K. & Werb, Z., Oct 22 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 43, p. 21704-21714 11 p.

Research output: Contribution to journal › Article

Open Access
Monocytes
Neutrophils
Breast Neoplasms
Neoplasms
Lung

In silico repurposing the Rac1 inhibitor NSC23766 for treating PTTG1-high expressing clear cell renal carcinoma

Hsieh, Y. Y., Liu, T. P. & Yang, P. M., Jan 1 2019, In : Pathology Research and Practice.

Research output: Contribution to journal › Article

Pituitary Neoplasms
Oncogenes
Renal Cell Carcinoma
Computer Simulation
Neoplasms

Integration of Bioinformatics Resources Reveals the Therapeutic Benefits of Gemcitabine and Cell Cycle Intervention in SMAD4-Deleted Pancreatic Ductal Adenocarcinoma

Hsieh, Y. Y., Liu, T. P., Chou, C. J., Chen, H. Y., Lee, K. H. & Yang, P. M., Sep 28 2019, In : Genes. 10, 10

Research output: Contribution to journal › Article

Open Access
gemcitabine
Computational Biology
Cell Cycle
Adenocarcinoma
Therapeutics

In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer Cells

Chen, J. C., Hsieh, Y. Y., Lo, H. L., Li, A., Chou, C. J. & Yang, P. M., Sep 9 2019, In : Biomolecules. 9, 9

Research output: Contribution to journal › Article

Open Access
Drug Resistance
Computer Simulation
Colorectal Neoplasms
Etoposide
Topoisomerase Inhibitors
4 Citations (Scopus)

KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC

Wang, H. J., Pochampalli, M., Wang, L. Y., Zou, J. X., Li, P. S., Hsu, S. C., Wang, B. J., Huang, S. H., Yang, P., Yang, J. C., Chu, C. Y., Hsieh, C. L., Sung, S. Y., Li, C. F., Tepper, C. G., Ann, D. K., Gao, A. C., Evans, C. P., Izumiya, Y., Chuu, C. P. & 3 others, Wang, W. C., Chen, H. W. & Kung, H. J., Jan 3 2019, In : Oncogene. 38, 1, p. 17-32

Research output: Contribution to journal › Article

Pyruvate Kinase
Androgen Receptors
Androgens
Castration
Prostatic Neoplasms

Leptin-derived peptides block leptin-induced proliferation by reducing expression of pro-inflammatory genes in hepatocellular carcinoma cells

Ho, Y., Wang, S. H., Chen, Y. R., Li, Z. L., Chin, Y. T., Yang, Y. C. S. H., Wu, Y. H., Su, K. W., Chu, H. R., Chiu, H. C., Crawford, D. R., Shih, Y. J., Grasso, P., Tang, H. Y., Lin, H. Y., Davis, P. J., Whang-Peng, J. & Wang, K., Nov 1 2019, In : Food and Chemical Toxicology. 133, 110808.

Research output: Contribution to journal › Article

leptin (116-130)
hepatoma
Leptin
leptin
Hepatocellular Carcinoma
1 Citation (Scopus)

Leukemia Inhibitory Factor Promotes Castration-resistant Prostate Cancer and Neuroendocrine Differentiation by Activated ZBTB46

Liu, Y-N., Niu, S., Chen, W-Y., Zhang, Q., Tao, Y., Chen, W-H., Jiang, K-C., Chen, X., Shi, H., Liu, A., Li, J., Li, Y., Lee, Y-C., Zhang, X. & Huang, J., Apr 8 2019, In : Clinical cancer research : an official journal of the American Association for Cancer Research.

Research output: Contribution to journal › Article

Leukemia Inhibitory Factor
Castration
Prostatic Neoplasms
Androgens
Therapeutics
1 Citation (Scopus)

LncRNA NORAD is repressed by the YAP pathway and suppresses lung and breast cancer metastasis by sequestering S100P

Tan, B. S., Yang, M. C., Singh, S., Chou, Y. C., Chen, H. Y., Wang, M. Y., Wang, Y. C. & Chen, R. H., Jan 1 2019, In : Oncogene.

Research output: Contribution to journal › Article

Lung Neoplasms
Long Noncoding RNA
Breast Neoplasms
Neoplasm Metastasis
Mi-2 Nucleosome Remodeling and Deacetylase Complex
2 Citations (Scopus)

miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2

Chen, H. Y., Lang, Y. D., Lin, H. N., Liu, Y. R., Liao, C. C., Nana, A. W., Yen, Y. & Chen, R. H., Dec 1 2019, In : Scientific Reports. 9, 1, 9687.

Research output: Contribution to journal › Article

Open Access
Catenins
Colorectal Neoplasms
Neoplasms
Side-Population Cells
Recurrence

MPT0G413, A novel HDAC6-selective inhibitor, and bortezomib synergistically exert anti-tumor activity in multiple myeloma cells

Huang, F. I., Wu, Y. W., Sung, T. Y., Liou, J. P., Lin, M. H., Pan, S. L. & Yang, C. R., Jan 1 2019, In : Frontiers in Oncology. 9, APR, 249.

Research output: Contribution to journal › Article

Open Access
Histone Deacetylases
Multiple Myeloma
Neoplasms
Histone Deacetylase Inhibitors
Growth
3 Citations (Scopus)

Natural Antioxidant Resveratrol Suppresses Uterine Fibroid Cell Growth and Extracellular Matrix Formation In Vitro and In Vivo

Chen, H-Y., Lin, P-H., Shih, Y-H., Wang, K-L., Hong, Y-H., Shieh, T-M., Huang, T-C. & Hsia, S-M., Apr 12 2019, In : Antioxidants. 8, 4

Research output: Contribution to journal › Article

Leiomyoma
Cell growth
Extracellular Matrix
Antioxidants
Growth
2 Citations (Scopus)

New paradigm of functional regulation by DNA mimic proteins: Recent updates

Wang, H. C., Chou, C. C., Hsu, K. C., Lee, C. H. & Wang, A. H. J., May 1 2019, In : IUBMB Life. 71, 5, p. 539-548 10 p.

Research output: Contribution to journal › Review article

DNA
Charge distribution
Proteins
Clustered Regularly Interspaced Short Palindromic Repeats
Uracil-DNA Glycosidase
14 Citations (Scopus)

Novel Common Genetic Susceptibility Loci for Colorectal Cancer

Schmit, S. L., Edlund, C. K., Schumacher, F. R., Gong, J., Harrison, T. A., Huyghe, J. R., Qu, C., Melas, M., Van Den Berg, D. J., Wang, H., Tring, S., Plummer, S. J., Albanes, D., Alonso, M. H., Amos, C. I., Anton, K., Aragaki, A. K., Arndt, V., Barry, E. L., Berndt, S. I. & 30 others, Bezieau, S., Bien, S., Bloomer, A., Boehm, J., Boutron-Ruault, M. C., Brenner, H., Brezina, S., Buchanan, D. D., Butterbach, K., Caan, B. J., Campbell, P. T., Carlson, C. S., Castelao, J. E., Chan, A. T., Chang-Claude, J., Chanock, S. J., Cheng, I., Cheng, Y. W., Chin, L. S., Church, J. M., Church, T., Coetzee, G. A., Cotterchio, M., Cruz Correa, M., Curtis, K. R., Duggan, D., Lin, Y., Liu, Y. R., Yen, Y. & Hsu, L., Feb 1 2019, In : Journal of the National Cancer Institute. 111, 2, p. 146-157 12 p.

Research output: Contribution to journal › Article

Genetic Loci
Genetic Predisposition to Disease
Colorectal Neoplasms
Genome-Wide Association Study
Confidence Intervals

RAB14 activates MARK signaling to promote bladder tumorigenesis

Chao, H., Deng, L., Xu, F., Fu, B., Zhu, Z., Dong, Z., Liu, Y-N. & Zeng, T., Feb 27 2019, In : Carcinogenesis.

Research output: Contribution to journal › Article

Urinary Bladder Neoplasms
Carcinogenesis
Urinary Bladder
Mitogen-Activated Protein Kinases
Twist-Related Protein 1

Resveratrol antagonizes thyroid hormone-induced expression of checkpoint and proliferative genes in oral cancer cells

Lin, C. C., Chin, Y. T., Shih, Y. J., Chen, Y. R., Chung, Y. Y., Lin, C. Y., Hsiung, C. N., Whang-Peng, J., Lee, S. Y., Lin, H. Y., Davis, P. J. & Wang, K., Jan 1 2019, In : Journal of Dental Sciences.

Research output: Contribution to journal › Article

Open Access
Mouth Neoplasms
Thyroxine
Thyroid Hormones
Genes
Cell Cycle Checkpoints

Rrm2b deletion causes mitochondrial metabolic defects in renal tubules

Chen, Y. F., Lin, I. H., Guo, Y. R., Chiu, W. J., Wu, M. S., Jia, W. & Yen, Y., Sep 13 2019, In : Scientific Reports. 9, 1, 1 p.

Research output: Contribution to journal › Article

Open Access
Kidney
Mitochondria
Kidney Diseases
DNA Replication
Knockout Mice
1 Citation (Scopus)

Structural insights to the heterotetrameric interaction between the vibrio parahaemolyticus pirA vp and pirB vp toxins and activation of the cry-like pore-forming domain

Lin, S. J., Chen, Y. F., Hsu, K. C., Chen, Y. L., Ko, T. P., Lo, C. F., Wang, H. C. & Wang, H. C., Apr 1 2019, In : Toxins. 11, 4, 233.

Research output: Contribution to journal › Article

Open Access
Vibrio parahaemolyticus
Penaeidae
Chemical activation
Necrosis
Hepatopancreas

Surgical outcomes of robotic transanal minimally invasive surgery for selected rectal neoplasms: A single-hospital experience

Huang, Y. J., Huang, Y. M., Wang, W. L., Tong, Y. S., Hsu, W. & Wei, P. L., Jan 1 2019, In : Asian Journal of Surgery.

Research output: Contribution to journal › Article

Open Access
Minimally Invasive Surgical Procedures
Robotics
Rectal Neoplasms
Neoplasms
Length of Stay

Tetrac and NDAT Induce Anti-proliferation via Integrin αvβ3 in Colorectal Cancers With Different K-RAS Status

Chin, Y-T., He, Z-R., Chen, C-L., Chu, H-C., Ho, Y., Su, P-Y., Yang, Y-C. S. H., Wang, K., Shih, Y-J., Chen, Y-R., Pedersen, J. Z., Incerpi, S., Nana, A. W., Tang, H-Y., Lin, H-Y., Mousa, S. A., Davis, P. J. & Whang-Peng, J., 2019, In : Frontiers in Endocrinology. 10, p. 130

Research output: Contribution to journal › Article

Integrins
Colorectal Neoplasms
HCT116 Cells
Neoplasms
HT29 Cells
2 Citations (Scopus)

The Ambivalent Role of lncRNA Xist in Carcinogenesis

Chen, Y. K. & Yen, Y., Apr 15 2019, In : Stem Cell Reviews and Reports. 15, 2, p. 314-323 10 p.

Research output: Contribution to journal › Article

Long Noncoding RNA
X Chromosome Inactivation
Carcinogenesis
Neoplasms
X Chromosome

The Role of Active Engagement of Peer Observation in the Acquisition of Surgical Skills in Virtual Reality Tasks for Novices

Chiu, H. Y., Kang, Y. N., Wang, W. L., Chen, C. C., Hsu, W., Tseng, M. F. & Wei, P. L., Nov 1 2019, In : Journal of Surgical Education. 76, 6, p. 1655-1662 8 p.

Research output: Contribution to journal › Article

virtual reality
Observation
Learning
energy
learning

The role of ubiquitin-specific peptidases in cancer progression

Young, M. J., Hsu, K. C., Lin, T. E., Chang, W. C. & Hung, J. J., May 27 2019, In : Journal of Biomedical Science. 26, 1, 42.

Research output: Contribution to journal › Review article

Open Access
Ubiquitin
Peptide Hydrolases
Ubiquitination
Neoplasms
Proteins
1 Citation (Scopus)

The synthetic retinoid ST1926 attenuates prostate cancer growth and potentially targets prostate cancer stem-like cells

Bahmad, H. F., Samman, H., Monzer, A., Hadadeh, O., Cheaito, K., Abdel-Samad, R., Hayar, B., Pisano, C., Msheik, H., Liu, Y-N., Darwiche, N. & Abou-Kheir, W., Jul 2019, In : Molecular Carcinogenesis. 58, 7, p. 1208-1220 13 p.

Research output: Contribution to journal › Article

Neoplastic Stem Cells
Retinoids
Prostatic Neoplasms
Growth
Apoptosis
1 Citation (Scopus)

ZBTB46, SPDEF, and ETV6: Novel Potential Biomarkers and Therapeutic Targets in Castration-Resistant Prostate Cancer

Fararjeh, A. F. S. & Liu, Y. N., Jun 8 2019, In : International Journal of Molecular Sciences. 20, 11

Research output: Contribution to journal › Review article

Open Access
biomarkers
Castration
Androgen Receptors
Biomarkers
Prostatic Neoplasms
2018
5 Citations (Scopus)

1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC

Ojha, R., Huang, H. L., HuangFu, W. C., Wu, Y. W., Nepali, K., Lai, M. J., Su, C. J., Sung, T. Y., Chen, Y. L., Pan, S. L. & Liou, J. P., Apr 25 2018, In : European Journal of Medicinal Chemistry. 150, p. 667-677 11 p.

Research output: Contribution to journal › Article

Hydroxamic Acids
Histone Deacetylase Inhibitors
Antineoplastic Agents
Protein Isoforms
Cells
2 Citations (Scopus)

2,3,5,4′-Tetrahydroxystilbene-2-O-β-glucoside potentiates self-renewal of human dental pulp stem cells via the AMPK/ERK/SIRT1 axis

Lin, C. Y., Chin, Y. T., Kuo, P. J., Lee, H. W., Huang, H. M., Lin, H. Y., Weng, I. T., Hsiung, C. N., Chan, Y. H. & Lee, S. Y., Oct 1 2018, In : International Endodontic Journal. 51, 10, p. 1159-1170 12 p.

Research output: Contribution to journal › Article

Sirtuin 1
Dental Pulp
AMP-Activated Protein Kinases
Mitogen-Activated Protein Kinase 3
Stem Cells
1 Citation (Scopus)

4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy

Lin, S. Y., Yeh, T. K., Song, J. S., Hung, M. S., Cheng, M. F., Liao, F. Y., Li, A. S., Cheng, S. Y., Lin, L. M., Chiu, C. H., Wu, M. H., Lin, Y. J., Hsiao, W., Sun, M., Wang, Y. H., Huang, C. H., Tang, Y. C., Chang, H. H., Huang, Z. T., Chao, Y. S. & 5 others, Shih, C., Pan, S. L., Wu, S. Y., Kuo, C. C. & Ueng, S. H., Apr 1 2018, In : Bioorganic Chemistry. 77, p. 600-607 8 p.

Research output: Contribution to journal › Article

Indoleamine-Pyrrole 2,3,-Dioxygenase
Tumors
Neoplasms
T-cells
Pharmaceutical Preparations
10 Citations (Scopus)

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes

Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Jan 29 2018, (Accepted/In press) In : Journal of Medicinal Chemistry.

Research output: Contribution to journal › Article

tau Proteins
Histone Deacetylase Inhibitors
Alzheimer Disease
Hydroxamic Acids
Phenotype

Age, but not short-term intensive swimming, affects chondrocyte turnover in zebrafish vertebral cartilage

Jian, Q. L., HuangFu, W. C., Lee, Y. H. & Liu, I. H., Jan 1 2018, In : PeerJ. 2018, 10, e5739.

Research output: Contribution to journal › Article

chondrocytes
Cartilage
Zebrafish
Chondrocytes
Danio rerio

A homozygous variant in RRM2B is associated with severe metabolic acidosis and early neonatal death

Penque, B. A., Su, L., Wang, J., Ji, W., Bale, A., Luh, F., Fulbright, R. K., Sarmast, U., Sega, A. G., Konstantino, M., Spencer-Manzon, M., Pierce, R., Yen, Y. & Lakhani, S. A., Jan 1 2018, (Accepted/In press) In : European Journal of Medical Genetics.

Research output: Contribution to journal › Article

Acidosis
Mutation
Ribonucleotide Reductases
Failure to Thrive
Lactic Acidosis
8 Citations (Scopus)

A low microRNA-630 expression confers resistance to tyrosine kinase inhibitors in EGFR-mutated lung adenocarcinomas via miR-630/YAP1/ERK feedback loop

Wu, D. W., Wang, Y. C., Wang, L., Chen, C. Y. & Lee, H., Jan 1 2018, In : Theranostics. 8, 5, p. 1256-1269 14 p.

Research output: Contribution to journal › Article

MicroRNAs
Protein-Tyrosine Kinases
bcl-Associated Death Protein
Neoplasms
Adenocarcinoma of lung
5 Citations (Scopus)

Amentoflavone inhibits hepatocellular carcinoma progression through blockage of ERK/NF-κB activation

Lee, K. C., Chen, W. T., Liu, Y. C., Lin, S. S. & Hsu, F. T., Sep 1 2018, In : In Vivo. 32, 5, p. 1097-1103 7 p.

Research output: Contribution to journal › Article

Extracellular Signal-Regulated MAP Kinases
Hepatocellular Carcinoma
Chemical activation
Tumors
Liver
4 Citations (Scopus)

Androgen deprivation therapy-induced epithelial-mesenchymal transition of prostate cancer through downregulating SPDEF and activating CCL2

Tsai, Y. C., Chen, W. Y., Abou-Kheir, W., Zeng, T., Yin, J. J., Bahmad, H., Lee, Y. C. & Liu, Y. N., May 1 2018, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 5, p. 1717-1727 11 p.

Research output: Contribution to journal › Article

Activating Transcription Factors
CC Chemokines
Epithelial-Mesenchymal Transition
Androgens
Prostatic Neoplasms

A new niclosamide derivatives-B17 can inhibit urological cancers growth through apoptosis-related pathway

Wu, C-L., Chen, C-L., Huang, H-S. & Yu, D-S., Jun 28 2018, In : Cancer Medicine.

Research output: Contribution to journal › Article

Niclosamide
Urologic Neoplasms
Apoptosis
Growth
Control Groups
3 Citations (Scopus)

A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo

Wu, Y. W., Hsu, K. C., Lee, H. Y., Huang, T. C., Lin, T. E., Chen, Y. L., Sung, T. Y., Liou, J. P., Hwang-Verslues, W. W., Pan, S. L. & HuangFu, W. C., Mar 13 2018, In : Frontiers in Pharmacology. 9, MAR, 205.

Research output: Contribution to journal › Article

Tubulin Modulators
Histone Deacetylases
Neoplasms
Tubulin
Molecular Docking Simulation