Ph.D. Program for Cancer Molecular Biology and Drug Discovery

  • No. 250 Wu-Xing Street

    11031 Taipei

Projects 2012 2020

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The Role of DDX3 in Human Papillomavirus-Infected Lung Tumorigenesis

Lee, H.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

Targeting Hif-1α by Zebularine for the Treatment of Colorectal Cancers

Yang, P.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

The Role of Cytoplasmic APe1 in Tumor Malignancy, Drug Resistance and Lung Cancer Prognosis

Lee, H.

8/1/127/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

探討攝護腺癌細胞中AMP-活化蛋白酶(AMPK)對調控上皮細胞與間質細胞轉換之角色與調控機轉之研究

Lee, K.

1/1/1310/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

The Role of miR-1 in RAS Mutation Prostate Cancer Metastasis

Liu, Y.

1/1/1310/31/13

Project: A - Government Institutionb - Ministry of Science and Technology

臺北醫學大學附設醫院之疾病個案收集與建立臺灣人體生物資料庫

Yen, Y.

8/27/1312/31/13

Project: A - Government Institutionf - Other (Funded by Government)

TMU101-AE1-B38

Huang, T.

1/1/1312/31/13

Project: B - Project of TMUh - Other (Funded by TMU)

TMU101-AE1-B19

Lee, K.

1/1/1312/31/13

Project: B - Project of TMUh - Other (Funded by TMU)

合併新穎AMPK活化劑與HDAC抑制劑用於癌症之研究

Lee, K.

1/1/1312/31/13

Project: B - Project of TMUh - Other (Funded by TMU)

iNOS 誘發Nrf2 細胞質表達促進肺腫瘤惡化

Lee, H.

2/1/131/31/14

Project: B - Project of TMUh - Other (Funded by TMU)

探討DNMT抑制劑治療大腸直腸癌之新機轉

Yang, P.

5/1/134/30/14

Project: C - Project of Alliancet - Taipei Medical University Shuang Ho Hospital

利用基因微陣列表現圖譜分析大腸直腸癌細胞之基因表現差異尋找具有抗癌效果之藥物及其調控機轉

Lee, K.

5/1/134/30/14

Project: C - Project of Alliancet - Taipei Medical University Shuang Ho Hospital

白藜蘆醇對卵巢囊腫和子宮肌瘤細胞增生之影響

Lin, H.

5/1/134/30/14

Project: C - Project of Alliances - Taipei Municipal Wanfang Hospital

研究miR-96在攝護腺癌轉移之功能與調控機制

Liu, Y.

5/1/134/30/14

Project: C - Project of Alliances - Taipei Municipal Wanfang Hospital

人類乳突病毒導致肺腫瘤化之可能機轉

Cheng, Y.

6/1/135/31/14

Project: C - Project of Allianceo - Taipei Medical University Hospital

TMU101-AE1-B25

Yang, P.

1/1/135/31/14

Project: B - Project of TMUh - Other (Funded by TMU)

TMU101-AE1-B34

Lin, H.

1/1/136/30/14

Project: B - Project of TMUh - Other (Funded by TMU)

Role of Androgen on Breast Cancer Development and Treatment

Lin, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Study of the mechanism of HPV involved tumorigenesis through Wnt signaling pathway related microRNA regulation

Cheng, Y.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

The role of DDX3 in human papillomavirus-infected lung tumorigenesis

Lee, H.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Association of Epidermal Growth Factor Receptor mutations with HPV16/18 E6 Oncoprotein Expression in Non-Small Cell Lung Cancer

Lee, H.

8/1/137/31/14

Project: C - Project of Allianceq - Tung's Taichung MetroHarbor Hospital

大腸直腸癌已躍居世界上癌症死亡率第二名,屬於固體型腫瘤,缺氧常見於此類 腫瘤,並誘發HIF-1α 表現而導致抗藥性及預後較差,因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑,可殺死癌 細胞而不影響正常細胞,對小鼠也不具毒性。我們初步結果顯示,Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現,代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性,對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下,經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制;也有研究報導指出,藥物會誘導癌細胞產生autophagy,造成細胞過度吞噬其內容 物而死亡,因此,autophagy在癌細胞為保護或是引發毒殺作用,目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活,但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示,除抑制HIF-1α 表現外,Zeb 也可活化AMPK、UPR/ER stress、以及autophagy, 因此我們推測Zeb 可在缺氧狀態下,促進autophagic cell death。3 年內我們將執行4 項 目標: (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。(第一年) (2) 研究Zeb 抑制HIF-1α表現之分子機轉。(第一年到第二年) (3) 研究Zeb 誘發autophagy之分子機轉。(第二年到第三年) (4) 探討Zeb 對缺氧導致抗藥性之作用。(第三年)

Yang, P.

8/1/137/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

Studies of Roles of SIRT7 in Cancer Biology

Tsai, Y.

1/1/1410/31/14

Project: A - Government Institutionb - Ministry of Science and Technology

TMU101-AE1-B20

Liu, Y.

1/1/1311/30/14

Project: B - Project of TMUh - Other (Funded by TMU)

103年度第二期癌症研究計畫

Yen, Y.

1/1/1412/31/14

Project: A - Government Institutionc - Ministry of Health and Welfare

The role of paxillin in tumor malignancy, drug resistance and clinical outcome in lung cancer

Lee, H.

1/1/1412/31/14

Project: A - Government Institutiona - National Health Research Institutes

The effect of vascular endothelial growth factor gene polymorphism in the pathogenesis and therapeutic response of pterygium

Cheng, Y.

8/1/1312/31/14

Project: C - Project of Allianceq - Tung's Taichung MetroHarbor Hospital

The role of miR-203 and miR-34a in EGFR activation prostate cancer metastasis

Liu, Y.

1/1/1412/31/14

Project: A - Government Institutiona - National Health Research Institutes

Preclinical evaluation of novel selective HDAC6 inhibitors for human cancers treatment

Pan, S.

1/1/1412/31/14

Project: A - Government Institutionc - Ministry of Health and Welfare

提升臨床試驗創新及競爭力計畫

Yen, Y., Chen, T., Lee, F., Wu, C. & Whang-Peng, J.

2/27/1412/31/14

Project: A - Government Institutionc - Ministry of Health and Welfare

TMU102-AE1-B23

Hsu, N.

1/1/1412/31/14

Project: B - Project of TMUg - Research Grants for Newly Hired Faculty

臺北醫學大學附設醫院之疾病個案收集與建立臺灣人體生物資料庫

Yen, Y.

1/1/1412/31/14

Project: A - Government Institutionf - Other (Funded by Government)

理性批判與在地實踐計畫

Yen, Y.

2/1/141/31/15

Project: A - Government Institutiond - Ministry of Education

TMU101-AE1-B48

Pan, S.

4/1/133/31/15

Project: B - Project of TMUh - Other (Funded by TMU)

探討黃連素對攝護腺癌細胞對調控上皮細胞與間質細胞轉換之角色與 調控機轉之研究

Lee, K.

6/1/145/31/15

Project: C - Project of Alliancet - Taipei Medical University Shuang Ho Hospital

白藜蘆醇對卵巢囊腫和子宮肌瘤細胞增生之影響

Lin, H.

6/1/145/31/15

Project: C - Project of Alliances - Taipei Municipal Wanfang Hospital

探討EZH2抑制劑UNC1999誘導大腸直腸癌細胞自噬之機轉

Yang, P.

6/1/145/31/15

Project: C - Project of Alliancet - Taipei Medical University Shuang Ho Hospital

新穎性抗微管藥物之藥理機轉探討與藥物研發

Pan, S.

6/1/145/31/15

Project: C - Project of Alliancet - Taipei Medical University Shuang Ho Hospital

The Role of Wnt5a and Hsp90 in the Wnt/Beta-Catenin Signaling Pathway of Colorectal Cancer (I)

Lee, K.

8/1/147/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

Investigation on the Epigenetic Regulation of Autophagy

Yang, P.

8/1/147/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

核糖核甘酸還原酉每抑制劑在人類乳突瘤病毒感染之非小細胞肺癌治療效果評估

Hsu, N.

8/1/147/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

NKX2-1在肺癌抗藥性之角色(先期補助)

Lee, H.

8/1/147/31/15

Project: B - Project of TMUh - Other (Funded by TMU)

探討攝護腺癌轉移過程中調控WNT 訊號傳遞之miRNA的作用機轉

Liu, Y.

6/1/147/31/15

Project: C - Project of Alliances - Taipei Municipal Wanfang Hospital

Combination Treatment of Tetrac- and Cetuximab-Induced Anti-Proliferation in Colorectal Cancer with Different APC Status (I)

Lin, H.

8/1/147/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

Drug Discovery and Pharmacological Study of Novel pan-HDAC Inhibitors as Anti-Angiogenic Drugs

Pan, S.

8/1/147/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

Effect of HMGA2 in Chemotherapy Response of Colorectal Cancer Patients with Different APC Status (I)

Yen, Y. & Wei, P.

8/1/147/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

Effect of RRM2 in Tumor Metastasis and Chemotherapy Response of Colorectal Cancer Patients with Different APC and K-Ras Status

Cheng, Y.

8/1/147/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

The Mechanistic Action of DDX3 in Colorectal Tumor Progression

Lee, H.

8/1/147/31/15

Project: A - Government Institutionb - Ministry of Science and Technology

The Role of Wnt5a and Hsp90 in the Wnt/Beta-Catenin Signaling Pathway of Colorectal Cancer (I)

Lee, K.

8/1/147/31/15

Project: B - Project of TMUh - Other (Funded by TMU)