Ph. D. Program in the Clinical Drug Development of Herbal Medicine

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2010

Neurocytoprotective effects of the bioactive constituents of Pueraria thomsonii in 6-hydroxydopamine (6-OHDA)-treated nerve growth factor (NGF)-differentiated PC12 cells

Lin, C. M., Lin, R. D., Chen, S. T., Lin, Y. P., Chiu, W. T., Lin, J. W., Hsu, F. L. & Lee, M. H., Dec 2010, In : Phytochemistry. 71, 17-18, p. 2147-2156 10 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Regulation of cytokine production by treating with Chinese tonic herbs in human peripheral blood mononuclear and human acute monocytic leukemia cells

Shin, H. Y., Kuo, Y. C., Hsu, F-L., Mao, Y. W. & Lee, M. H., Dec 2010, In : Journal of Food and Drug Analysis. 18, 6, p. 414-424 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Study of the natural product intermediates of steviolbioside, steviol, and isosteviol; O- and N-acylated forms of benzotriazoyl esters

Lee, L. W., Chen, S. M., Lin, C. C., Sheu, S. Y. & Lin, P. Y., 2010, In : Journal of the Chinese Chemical Society. 57, 6, p. 1232-1236 5 p.

Research output: Contribution to journalArticle

2009

Active constituents from Sophora japonica exhibiting cellular tyrosinase inhibition in human epidermal melanocytes

Lo, Y. H., Lin, R. D., Lin, Y. P., Liu, Y. L. & Lee, M. H., Jul 30 2009, In : Journal of Ethnopharmacology. 124, 3, p. 625-629 5 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Anti-inflammatory effects of daidzein on primary astroglial cell culture

Liu, M. H., Lin, Y. S., Sheu, S. Y. & Sun, J. S., Jun 1 2009, In : Nutritional Neuroscience. 12, 3, p. 123-134 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Effects of burdock extract preparation on gastric mucosal protection

Chen, F. A., Lee, S. C., Chao, H. R., Fu, W. C., Hsu, M. C., Horng, C. T., Wang, C. C., Matsui, H. & Agoramoorthy, G., Apr 2009, In : Asian Journal of Chemistry. 21, 4, p. 3015-3022 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Ellagitannins from Terminalia calamansanai induced apoptosis in HL-60 cells

Chen, L. G., Huang, W. T., Lee, L. T. & Wang, C. C., Jun 2009, In : Toxicology in Vitro. 23, 4, p. 603-609 7 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Melanogenesis inhibition by gallotannins from Chinese galls in B16 mouse melanoma cells

Chen, L. G., Chang, W. L., Lee, C. J., Lee, L. T., Shih, C. M. & Wang, C. C., Aug 2009, In : Biological and Pharmaceutical Bulletin. 32, 8, p. 1447-1452 6 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Neural cell protective compounds isolated from Phoenix hanceana var. formosana

Lin, Y. P., Chen, T. Y., Tseng, H. W., Lee, M. H. & Chen, S. T., Jun 2009, In : Phytochemistry. 70, 9, p. 1173-1181 9 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)
25 Citations (Scopus)

Taiwanese native plants inhibit matrix metalloproteinase-9 activity after ultraviolet B irradiation

Lee, Y. L., Lee, M. H., Chang, H. J., Huang, P. Y., Huang, I. J., Cheng, K. T. & Leu, S. J., Mar 2009, In : Molecules. 14, 3, p. 1062-1071 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2008

Anti-inflammatory activity of mangostins from Garcinia mangostana

Chen, L. G., Yang, L-L. & Wang, C. C., Feb 2008, In : Food and Chemical Toxicology. 46, 2, p. 688-693 6 p.

Research output: Contribution to journalArticle

263 Citations (Scopus)

Anti-inflammatory constituents of Zingiber zerumbet

Chien, T. Y., Chen, L. G., Lee, C. J., Lee, F. Y. & Wang, C. C., Oct 1 2008, In : Food Chemistry. 110, 3, p. 584-589 6 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)
89 Citations (Scopus)

The effect of Chinese herbal medicines on TNF-α induced matrix metalloproteinase-1, -9 activities and interleukin-8 secretion

Lee, M. H., Yang, Y. Y., Tsai, Y-H., Lee, Y. L., Huang, P. Y., Huang, I. J., Cheng, K. T. & Leu, S. J., Oct 2008, In : Botanical Studies. 49, 4, p. 301-309 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
18 Citations (Scopus)
2007

Analysis of the sesquiterpenoids in processed atractylodis rhizoma

Wang, K. T., Chen, L. G., Yang, L-L., Ke, W. M., Chang, H. C. & Wang, C. C., Jan 2007, In : Chemical and Pharmaceutical Bulletin. 55, 1, p. 50-56 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Antitumor effects of osthol from Cnidium monnieri: An in vitro and in vivo study

Chou, S-Y., Hsu, C-S., Wang, K. T., Wang, M. C. & Wang, C. C., Mar 2007, In : Phytotherapy Research. 21, 3, p. 226-230 5 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)

Effects of coumestrol on neonatal and adult mice osteoblasts activities

Sun, J. S., Li, Y. Y., Liu, M. H. & Sheu, S. Y., Apr 2007, In : Journal of Biomedical Materials Research - Part A. 81, 1, p. 214-223 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Immuno-enhancement effects of Huang Qi Liu Yi Tang in a murine model of cyclophosphamide-induced leucopenia

Huang, G. C., Wu, L. S., Chen, L. G., Yang, L-L. & Wang, C. C., Jan 19 2007, In : Journal of Ethnopharmacology. 109, 2, p. 229-235 7 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
21 Citations (Scopus)

Prevention of hepatic oxidative injury by Xiao-Chen-Chi-Tang in mice

Tseng, S. H., Chien, T. Y., Tzeng, C. F., Lin, Y. H., Wu, C. H. & Wang, C. C., May 4 2007, In : Journal of Ethnopharmacology. 111, 2, p. 232-239 8 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2006

Antioxidant and heme oxygenase-1 (HO-1)-induced effects of selected Taiwanese plants

Lee, M. H., Jiang, C. B., Juan, S. H., Lin, R. D. & Hou, W. C., Feb 2006, In : Fitoterapia. 77, 2, p. 109-115 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Bioactive constituents of Spatholobus suberectus in regulating tyrosinase-related proteins and mRNA in HEMn cells

Lee, M. H., Lin, Y. P., Hsu, F-L., Zhan, G. R. & Yen, K. Y., Jun 2006, In : Phytochemistry. 67, 12, p. 1262-1270 9 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Building a web-based e-learning model for preventing club drug abuse

Li, Y. C., Tsai, W. C., Huang, C. Y., Hu, C. M., Wang, C. C., Chen, J. L. & Hsu, C-Y., Feb 1 2006, In : Journal on Information Technology in Healthcare. 4, 1, p. 38-48 11 p.

Research output: Contribution to journalArticle

Cantharidin-induced cytotoxicity and cyclooxygenase 2 expression in human bladder carcinoma cell line

Huan, S. K. H., Lee, H. H., Liu, D. Z., Wu, C. C. & Wang, C. C., Jun 1 2006, In : Toxicology. 223, 1-2, p. 136-143 8 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Cosmetic applications of selected traditional Chinese herbal medicines

Wang, K-H., Lin, R. D., Hsu, F-L., Huang, Y-H., Chang, H. C., Huang, C. Y. & Lee, M-H., Jul 19 2006, In : Journal of Ethnopharmacology. 106, 3, p. 353-359 7 p.

Research output: Contribution to journalArticle

140 Citations (Scopus)

Effects of three purgative decoctions on inflammatory mediators

Tseng, S. H., Lee, H. H., Chen, L. G., Wu, C. H. & Wang, C. C., Apr 21 2006, In : Journal of Ethnopharmacology. 105, 1-2, p. 118-124 7 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
69 Citations (Scopus)

Monitoring medical abortion using mifepristone/misoprostol combination with ultrasonogram and serum human chorionic gonadotropin

Chou, S-Y., Chen, C. Y., Chiang, H. K., Chow, P. K., Wang, C. C. & Hsu, C-S., Mar 2006, In : Taiwanese Journal of Obstetrics and Gynecology. 45, 1, p. 48-52 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Natural products of cosmetics: Analysis of extracts of plants endemic to Taiwan for the presence of tyrosinase-inhibitory, melanin-reducing, and free radical scavenging activities

Jiang, C. B., Chang, M. J., Wen, C. L., Lin, Y. P., Hsu, F-L. & Lee, M. H., Dec 2006, In : Journal of Food and Drug Analysis. 14, 4, p. 346-352 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Phenolic constituents of Malus doumeri var. formosana in the field of skin care

Leu, S. J., Lin, Y. P., Lin, R. D., Wen, C. L., Cheng, K. T., Hsu, F-L. & Lee, M. H., Apr 2006, In : Biological and Pharmaceutical Bulletin. 29, 4, p. 740-745 6 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Pro-oxidant and cytotoxic activities of atractylenolide I in human promyeloleukemic HL-60 cells

Wang, C. C., Lin, S. Y., Cheng, H. C. & Hou, W. C., Aug 2006, In : Food and Chemical Toxicology. 44, 8, p. 1308-1315 8 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2005

Anti-inflammatory effects of indomethacin's methyl ester derivative and induction of apoptosis in HL-60 cells

Chao, S. H., Wu, A-B., Lee, C. J., Chen, F. A. & Wang, C. C., Dec 2005, In : Biological and Pharmaceutical Bulletin. 28, 12, p. 2206-2210 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
40 Citations (Scopus)

Antitumor effects of zerumbone from Zingiber zerumbet in P-388D1 cells in vitro and in vivo

Huang, G. C., Chien, T. Y., Chen, L. G. & Wang, C. C., Mar 2005, In : Planta Medica. 71, 3, p. 219-224 6 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Monoamine oxidase B (MAO-B) inhibition by active principles from Uncaria rhynchophylla

Hou, W. C., Lin, R. D., Chen, C. T. & Lee, M. H., Aug 22 2005, In : Journal of Ethnopharmacology. 100, 1-2, p. 216-220 5 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

The phenolic constituent and free radical scavenging activities of Gynura formosona Kiamnra

Hou, W. C., Lin, R. D., Li, Z-H., Huang, Y. H., Hsu, F-L. & Lee, M. H., Mar 2005, In : Journal of the Science of Food and Agriculture. 85, 4, p. 615-621 7 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
2004

Detection of glutathione reductase after electrophoresis on native or sodium dodecyl sulfate polyacrylamide gels

Hou, W. C., Liang, H. J., Wang, C. C. & Liu, D. Z., Sep 2004, In : Electrophoresis. 25, 17, p. 2926-2931 6 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Photolysis of NSAIDs. IV. Photoproducts of zomepirac determined by LC-ESI-MS

Wang, C. C., Chen, F. A., Chen, C. J., Chao, S. H. & Wu, A-B., Dec 2004, In : Biomedical Chromatography. 18, 10, p. 820-825 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Study on the stevioside analogues of steviolbioside, steviol, and isosteviol 19-alkyl amide dimers: Synthesis and cytotoxic and antibacterial activity

Lin, L. H., Lee, L. W., Sheu, S. Y. & Lin, P. Y., Sep 2004, In : Chemical and Pharmaceutical Bulletin. 52, 9, p. 1117-1122 6 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
2003

Antitumor principle constituents of Myrica rubra var. acuminata

Yang, L-L., Chang, C. C., Chen, L. G. & Wang, C. C., May 7 2003, In : Journal of Agricultural and Food Chemistry. 51, 10, p. 2974-2979 6 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Cytotoxic Activity of Coumarins from the Fruits of Cnidium monnieri on Leukemia Cell Lines

Yang, L-L., Wang, M. C., Chen, L. G. & Wang, C. C., Dec 2003, In : Planta Medica. 69, 12, p. 1091-1095 5 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Differential effects of natural polyphenols on neuronal survival in primary cultured central neurons against glutamate- and glucose deprivation-induced neuronal death

Lee, H. H., Yang, L-L., Wang, C. C., Hu, S. Y., Chang, S. F. & Lee, Y-H., Oct 3 2003, In : Brain Research. 986, 1-2, p. 103-113 11 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)

Effects of 6-Gingerol, an antioxidant from ginger, on inducing apoptosis in human leukemic HL-60 cells

Wang, C. C., Chen, L. G., Lee, L. T. & Yang, L-L., Nov 2003, In : In Vivo. 17, 6, p. 641-645 5 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Free radical-scavenging activity of Taiwanese native plants

Hou, W. C., Lin, R. D., Cheng, K. T., Hung, Y. T., Cho, C. H., Chen, C. H., Hwang, S. Y. & Lee, M. H., Mar 2003, In : Phytomedicine. 10, 2-3, p. 170-175 6 p.

Research output: Contribution to journalArticle

138 Citations (Scopus)

Inhibition of monoamine oxidase B (MAO-B) by Chinese herbal medicines

Lin, R. D., Hou, W. C., Yen, K. Y. & Lee, M. H., Nov 2003, In : Phytomedicine. 10, 8, p. 650-656 7 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
16 Citations (Scopus)

Patatin, the tuber storage protein of potato (Solanum tuberosum L.), exhibits antioxidant activity in vitro

Liu, Y. W., Han, C. H., Lee, M. H., Hsu, F-L. & Hou, W. C., Jul 16 2003, In : Journal of Agricultural and Food Chemistry. 51, 15, p. 4389-4393 5 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)
6 Citations (Scopus)