Ph. D. Program in the Clinical Drug Development of Herbal Medicine

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2014

Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents

Mehndiratta, S., Chiang, Y-F., Lai, M-J., Lee, H. Y., Chen, M. C., Kuo, C-C., Chang, C-Y., Chang, J-Y. & Liou, J. P., Sep 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 17, p. 4917-4923 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Deep sea water prevents balloon angioplasty-induced hyperplasia through MMP-2: An in vitro and in vivo study

Li, P. C., Pan, C. H., Sheu, M. J., Wu, C. C., Ma, W. F. & Wu, C. H., May 13 2014, In : PLoS One. 9, 5, e96927.

Research output: Contribution to journalArticle

18 Citations (Scopus)
11 Citations (Scopus)

NPRL-Z-1, as a new topoisomerase II poison, induces cell apoptosis and ROS generation in human renal carcinoma cells

Wu, S. Y., Pan, S. L., Xiao, Z. Y., Hsu, J. L., Chen, M. C., Lee, K. H. & Teng, C. M., Nov 5 2014, In : PLoS One. 9, 11, e112220.

Research output: Contribution to journalArticle

9 Citations (Scopus)

NSC746364, a G-quadruplex-stabilizing agent, suppresses cell growth of A549 human lung cancer cells through activation of the ATR/Chk1-dependent pathway

Chung, Y. L., Pan, C. H., Liou, W. H., Sheu, M. J., Lin, W. H., Chen, T. C., Huang, H. S. & Wu, C. H., 2014, In : Journal of Pharmacological Sciences. 124, 1, p. 7-17 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Osteoporosis is associated with antiepileptic drugs: A population-based study

Wu, F. J., Sheu, S. Y. & Lin, H. C., Sep 1 2014, In : Epileptic Disorders. 16, 3, p. 333-342 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Pharmacological effects of "Jutsu" (Atractylodis rhizome and Atractylodis lanceae rhizome) on 1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-Induced head twitch response in mice (I)

Murayama, C., Wang, C. C., Michihara, S. & Norimoto, H., Sep 18 2014, In : Molecules. 19, 9, p. 14979-14986 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Stimulation of osteogenic activity in human osteoblast cells by edible Uraria crinita

Mao, Y. W., Lin, R. D., Hung, H. C. & Lee, M. H., Jun 18 2014, In : Journal of Agricultural and Food Chemistry. 62, 24, p. 5581-5588 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2013

A novel prenylated C6-C3 compound with estrogen-like activity from the fruits of Illicium arborescens

Liaw, C. C., Chen, Y. C., Fazary, A. E., Hsieh, J. L., Chen, S. Y., Chien, C. T., Sheu, S. Y., Kuo, Y. H., Chiang, B. L. & Shen, Y. C., 2013, In : Phytochemistry Letters. 6, 3, p. 397-402 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Biological characterization of oxidized hyaluronic acid/resveratrol hydrogel for cartilage tissue engineering

Sheu, S. Y., Chen, W. S., Sun, J. S., Lin, F. H. & Wu, T., Dec 2013, In : Journal of Biomedical Materials Research - Part A. 101, 12, p. 3457-3466 10 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Biotransformation of dihydroisosteviol and the effects of transformed products on steroidogenic gene expressions

Chang, S. F., Yang, L. M., Huang, T. J., Chen, C. Y., Sheu, S. Y., Liu, P. C. & Lin, S. J., Nov 2013, In : Phytochemistry. 95, p. 268-276 9 p.

Research output: Contribution to journalArticle

Chemical and pharmacological investigation of micropropagated Hygrophila pogonocalyx produced from leaf explants

Ho, C. W., Lin, R. D., Li, Z-H., Lin, C. H., Wen, C. L., Tseng, Y. T. & Lee, M. H., 2013, In : Botanical Studies. 54, 1, 51.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Correlations of the components of tea tree oil with its antibacterial effects and skin irritation

Lee, C. J., Chen, L. W., Chen, L. G., Chang, T. L., Huang, C. W., Huang, M. C. & Wang, C. C., Jun 2013, In : Journal of Food and Drug Analysis. 21, 2, p. 169-176 8 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Immunomodulatory effects of hedysarum polybotrys extract in mice macrophages, splenocytes and leucopenia

Huang, G. C., Lee, C. J., Wang, K. T., Weng, B. C., Chien, T. Y., Tseng, S. H. & Wang, C. C., Dec 2013, In : Molecules. 18, 12, p. 14862-14875 14 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization

Guo, Y. C., Chang, C. M., Hsu, W. L., Chiu, S. J., Tsai, Y. T., Chou, Y. H., Hou, M. F., Wang, J. Y., Lee, M. H., Tsai, K. L. & Chang, W. C., Jun 2013, In : Molecules. 18, 6, p. 6584-6596 13 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2012

Antioxidant activities of different wild bitter gourd (Momordica charantia l. var. abbreviata seringe) cultivars

Lu, Y. L., Liu, Y. H., Chyuan, J. H., Cheng, K. T., Liang, W. L. & Hou, W. C., Apr 2012, In : Botanical Studies. 53, 2, p. 207-214 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
8 Citations (Scopus)

Chemical and biological evaluation of nephrocizin in protecting nerve growth factor-differentiated PC12 cells by 6-hydroxydopamine-induced neurotoxicity

Lin, Y. P., Chen, T. Y., Tseng, H. W., Lee, M. H. & Chen, S. T., Dec 2012, In : Phytochemistry. 84, p. 102-115 14 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Effects of velvet antler with blood on bone in ovariectomized rats

Tseng, S. H., Sung, H. C., Chen, L. G., Lai, Y. J., Wang, K. T., Sung, C. H. & Wang, C. C., Sep 2012, In : Molecules. 17, 9, p. 10574-10585 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
18 Citations (Scopus)

Heptadecanols from the leaves of Persea americana var. americana

Li, Z-H., Tsai, Y. F., Huang, T. T., Chen, P. Y., Liang, W. L. & Lee, C. K., May 15 2012, In : Food Chemistry. 132, 2, p. 921-924 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Inhibitory effects of terpenoids from the fermented broth of the ascomycete stilbohypoxylon elaeicola YMJ173 on nitric oxide production in RAW264.7 macrophages

Wang, G. J., Liang, W. L., Ju, Y. M., Yang, W. B., Chang, Y. W. & Li, Z-H., Jan 2012, In : Chemistry and Biodiversity. 9, 1, p. 131-138 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Scutellaria baicalensis alleviates cantharidin-induced rat hemorrhagic cystitis through inhibition of cyclooxygenase-2 overexpression

Huan, S. K. H., Wang, K. T., Yeh, S. D., Lee, C. J., Lin, L. C., Liu, D. Z. & Wang, C. C., Jun 2012, In : Molecules. 17, 6, p. 6277-6289 13 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Stimulatory effect of puerarin on bone formation through co-activation of nitric oxide and bone morphogenetic protein-2/ mitogen-activated protein kinases pathways in mice

Sheu, S. Y., Tsai, C. C., Sun, J. S., Chen, M. H., Liu, M. H. & Sun, M. G., Oct 20 2012, In : Chinese Medical Journal. 125, 20, p. 3646-3653 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Synthesis and Evaluation of Cantharidinimides on Human Cancer Cells

Tseng, I. J., Sheu, S. Y., Lin, P. Y., Lee, J. A., Ou, K. L. & Lee, L. W., Oct 2012, In : Journal of Experimental and Clinical Medicine(Taiwan). 4, 5, p. 280-283 4 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

The antinociceptive and anti-inflammatory activities of Petasites formosanus Kitamura extract

Lin, S. Y., Teng, H. L., Tseng, S. H., Chen, L. G. & Wang, C. C., Oct 2012, In : Botanical Studies. 53, 4, p. 431-438 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Wu-Chia-Pi solution attenuates carbon tetrachloride-induced hepatic injury through the antioxidative abilities of its components acteoside and quercetin

Huan, S. K. H., Wang, K. T., Lee, C. J., Sung, C. H., Chien, T. Y. & Wang, C. C., Dec 2012, In : Molecules. 17, 12, p. 14673-14684 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
28 Citations (Scopus)
2011

Antibacterial and cytotoxic activities of different wild bitter gourd cultivars (Momordica charantia L. var. abbreviata Seringe)

Lu, Y. L., Liu, Y. H., Liang, W. L., Chuang, J. H., Cheng, K. T., Liang, H. J. & Hou, W. C., Oct 2011, In : Botanical Studies. 52, 4, p. 427-434 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Anti-inflammatory and free radial scavenging activities of the constituents isolated from machilus zuihoensis

Mao, Y. W., Tseng, H. W., Liang, W. L., Chen, I. S., Chen, S. T. & Lee, M. H., Nov 2011, In : Molecules. 16, 11, p. 9451-9466 16 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Anti-inflammatory effects of resveratrol and oligostilbenes from vitis thunbergii var. taiwaniana against lipopolysaccharide-induced arthritis

Wang, K. T., Chen, L. G., Tseng, S. H., Huang, J. S., Hsieh, M-S. & Wang, C. C., Apr 27 2011, In : Journal of Agricultural and Food Chemistry. 59, 8, p. 3649-3656 8 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Antioxidant and semicarbazide-sensitive amine oxidase inhibitory activities of glucuronic acid hydroxamate

Liu, Y. H., Liang, W. L., Lee, C. C., Tsai, Y. F. & Hou, W. C., Nov 15 2011, In : Food Chemistry. 129, 2, p. 423-428 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Anti-oxidative abilities of essential oils from atractylodes ovata rhizome

Wang, C. C., Wang, K. T., Chen, L. G., Chou, D. S. & Liang, W. L., 2011, In : Evidence-based Complementary and Alternative Medicine. 2011, 204892.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Chemical constituents of the fermented broth of the ascomycete theissenia cinerea 89091602

Liang, W. L., Hsiao, C. J., Ju, Y. M., Lee, L. H. & Li, Z-H., Dec 2011, In : Chemistry and Biodiversity. 8, 12, p. 2285-2290 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Gastroprotective effects of Ping-Wei San on indomethacin-induced gastric ulcer

Tiong, C., Liang, W. L., Liu, H. Y., Wang, K. T., Chang, C. C. & Wang, C. C., Dec 2011, In : Journal of Food and Drug Analysis. 19, 4

Research output: Contribution to journalArticle

5 Citations (Scopus)

Hypolipidemic effects of three purgative decoctions

Wang, C. C., Tseng, S. H., Chien, T. Y., Chen, J. R. & Lin, I. H., 2011, In : Evidence-based Complementary and Alternative Medicine. 2011, 249254.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Icariin inhibits osteoclast differentiation and bone resorption by suppression of MAPKs/NF-κB regulated HIF-1α and PGE2 synthesis

Hsieh, T. P., Sheu, S. Y., Sun, J. S. & Chen, M. H., Jan 15 2011, In : Phytomedicine. 18, 2-3, p. 176-185 10 p.

Research output: Contribution to journalArticle

123 Citations (Scopus)

Protective effect of dried safflower petal aqueous extract and its main constituent, carthamus yellow, against lipopolysaccharide-induced inflammation in RAW264.7 macrophages

Wang, C. C., Choy, C-S., Liu, Y. H., Cheah, K. P., Li, J. S., Wang, J. T. J., Yu, W. Y., Lin, C-W., Cheng, H. W. & Hu, C-M., Jan 30 2011, In : Journal of the Science of Food and Agriculture. 91, 2, p. 218-225 8 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

The correlation between skin-care effects and phytochemical contents in Lamiaceae plants

Lee, C. J., Chen, L. G., Chang, T. L., Ke, W. M., Lo, Y. F. & Wang, C. C., Feb 2011, In : Food Chemistry. 124, 3, p. 833-841 9 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

The immuno-regulatory effects of Schisandra chinensis and its constituents on human monocytic leukemia cells

Lin, R. D., Mao, Y. W., Leu, S. J., Huang, C. Y. & Lee, M. H., Jun 2011, In : Molecules. 16, 6, p. 4836-4849 14 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

The protective effects of coumestrol against amyloid-beta peptide- and lipopolysaccharide-induced toxicity on mice astrocytes

Liu, M. H., Tsuang, F. Y., Sheu, S. Y., Sun, J. S. & Shih, C. M., Jul 2011, In : Neurological Research. 33, 6, p. 663-672 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
15 Citations (Scopus)
2010

Anti-inflammatory effects of Punica granatum Linne in vitro and in vivo

Lee, C. J., Chen, L. G., Liang, W. L. & Wang, C. C., Jan 15 2010, In : Food Chemistry. 118, 2, p. 315-322 8 p.

Research output: Contribution to journalArticle

129 Citations (Scopus)

Cytotoxic constituents of Hydrangea angustipetala on human gastric carcinoma cells

Hsieh, C. R., Yu, P. J., Chen, L. G., Chaw, S. M., Chang, C. C. & Wang, C. C., Jan 2010, In : Botanical Studies. 51, 1, p. 45-51 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Gastroprotective activity of atractylenolide III from Atractylodes ovata on ethanol-induced gastric ulcer in vitro and in vivo

Wang, K. T., Chen, L. G., Wu, C. H., Chang, C. C. & Wang, C. C., Mar 2010, In : Journal of Pharmacy and Pharmacology. 62, 3, p. 381-388 8 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Ghrelin improves lps-induced gastrointestinal motility disturbances: Roles of no and prostaglandin E2

Chen, Y. T., Tsai, S. H., Sheu, S. Y. & Tsai, L-H., Feb 2010, In : Shock. 33, 2, p. 205-212 8 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Icariin isolated from Epimedium pubescens regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfa1 expression

Hsieh, T. P., Sheu, S. Y., Sun, J. S., Chen, M. H. & Liu, M. H., May 2010, In : Phytomedicine. 17, 6, p. 414-423 10 p.

Research output: Contribution to journalArticle

123 Citations (Scopus)

Icariin protects murine chondrocytes from lipopolysaccharide-induced inflammatory responses and extracellular matrix degradation

Liu, M. H., Sun, J. S., Tsai, S. W., Sheu, S. Y. & Chen, M. H., Jan 2010, In : Nutrition Research. 30, 1, p. 57-65 9 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Illicaborins A-C, three prenylated C6-C3 compounds from the fruits of Illicium arborescens

Lin, Y. X., Fazary, A. E., Chen, S. Y., Chien, C. T., Kuo, Y. H., Sheu, S. Y. & Shen, Y. C., Dec 2010, In : Food Chemistry. 123, 4, p. 1105-1111 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)