Ph. D. Program in the Clinical Drug Development of Herbal Medicine

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2017

Multiple activities of punica granatum linne against acne vulgaris

Lee, C-J., Chen, L. G., Liang, W-L. & Wang, C-C., Jan 12 2017, In : International Journal of Molecular Sciences. 18, 1, 141.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Pharmacokinetics and tissue distribution of five major triterpenoids after oral administration of Rhizoma Alismatis extract to rats using ultra high-performance liquid chromatography–tandem mass spectrometry

Xu, W., Li, X., Lin, N., Zhang, X., Huang, X., Wu, T., Tai, Y., Chen, S., Wu, C. H., Huang, M. & Wu, S., Nov 30 2017, In : Journal of Pharmaceutical and Biomedical Analysis. 146, p. 314-323 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Proteome analysis of human embryonic stem cells organelles

Shekari, F., Nezari, H., Larijani, M. R., Han, C. L., Baharvand, H., Chen, Y. J. & Salekdeh, G. H., Jun 6 2017, In : Journal of Proteomics. 162, p. 108-118 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: A key role of AMPK and Akt/mTOR signaling

Chang, C. H., Lee, C. Y., Lu, C. C., Tsai, F. J., Hsu, Y. M., Tsao, J. W., Juan, Y. N., Chiu, H. Y., Yang, J. S. & Wang, C. C., Mar 1 2017, In : International Journal of Oncology. 50, 3, p. 873-882 10 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Ring-opened tetrahydro-γ-carbolines display cytotoxicity and selectivity with histone deacetylase isoforms

Nepali, K., Lee, H-Y., Lai, M-J., Ojha, R., Wu, T. Y., Wu, G. X., Chen, M-C. & Liou, J-P., Feb 15 2017, In : European Journal of Medicinal Chemistry. 127, p. 115-127 13 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

The apoptotic mechanisms of MT-6, a mitotic arrest inducer, in human ovarian cancer cells

Chen, M. C., Kuo, Y. C., Hsu, C. M., Chen, Y. L., Shen, C. C., Teng, C. M. & Pan, S. L., Apr 7 2017, In : Scientific Reports. 7, 46149.

Research output: Contribution to journalArticle

Toxicological effects of NCKU-21, a phenanthrene derivative, on cell growth and migration of A549 and CL1-5 human lung adenocarcinoma cells

Liao, H. F., Pan, C. H., Chou, P. Y., Chen, Y. F., Wu, T. S., Sheu, M. J. & Wu, C. H., Sep 1 2017, In : PLoS One. 12, 9, e0185021.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2016

2,3,5,4′-tetrahydroxystilbene-2-O- β -glucoside isolated from Polygoni Multiflori ameliorates the development of periodontitis

Chin, Y. T., Hsieh, M. T., Lin, C. Y., Kuo, P. J., Yang, Y. C. S. H., Shih, Y. J., Lai, H. Y., Cheng, G. Y., Tang, H. Y., Lee, C. C., Lee, S. Y., Wang, C. C., Lin, H. Y., Fu, E., Whang-Peng, J. & Liu, L. F., 2016, In : Mediators of Inflammation. 2016, 6953459.

Research output: Contribution to journalArticle

12 Citations (Scopus)

An in vivo molecular response analysis of colorectal cancer treated with Astragalus membranaceus extract

Tseng, A., Yang, C. H., Chen, C. H., Chen, C. H., Hsu, S. L., Lee, M. H., Lee, H. C. & Su, L. J., Feb 1 2016, In : Oncology Reports. 35, 2, p. 659-668 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Anti-inflammatory and Antinociceptive Constituents of Atractylodes japonica Koidzumi

Chen, L. G., Jan, Y. S., Tsai, P. W., Norimoto, H., Michihara, S., Murayama, C. & Wang, C. C., Mar 23 2016, In : Journal of Agricultural and Food Chemistry. 64, 11, p. 2254-2262 9 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Antinociceptive and anti-inflammatory effects of zerumbone against mono-iodoacetate-induced arthritis

Chien, T. Y., Huang, S. K. H., Lee, C. J., Tsai, P. W. & Wang, C. C., Feb 1 2016, In : International Journal of Molecular Sciences. 17, 2, 249.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Antiobesity and antihyperlipidaemic effects of Yan-Sheng-Yin in animals and humans

Wu, C. H., Pan, C. H., Lee, C. K., Sheu, M. J., Liu, F. C., Wang, G. J. & Wu, C. H., Jun 1 2016, In : Journal of Functional Foods. 24, p. 173-182 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Chemical Constituents from Termite-associated Xylaria acuminatilongissima YMJ623

Cho, T. Y., Wang, G. J., Ju, Y. M., Chen, M. C. & Lee, T. H., May 1 2016, In : Journal of the Chinese Chemical Society. 63, 5, p. 404-409 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Effects of Dang-Gui-Bu-Xue-Tang, an herbal decoction, on iron uptake in iron-deficient anemia

Huang, G. C., Chen, S. Y., Tsai, P. W., Ganzon, J. G., Lee, C. J., Shiah, H. S. & Wang, C. C., Mar 2 2016, In : Drug Design, Development and Therapy. 10, p. 949-957 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Effects of different forages on the chemical compositions and antiosteoporotic activities of velvet antlers

Tseng, S. H., Chen, L. G., Lai, Y. J., Wang, K. T. & Wang, C. C., Aug 1 2016, In : Animal science journal = Nihon chikusan Gakkaiho. 87, 8, p. 989-996 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
15 Citations (Scopus)

Increased Fall Risk in Patients Receiving Androgen Deprivation Therapy for Prostate Cancer

Wu, F. J., Sheu, S. Y., Lin, H. C. & Chung, S. D., Sep 1 2016, In : Urology. 95, p. 145-150 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

LTP-1, a novel antimitotic agent and Stat3 inhibitor, inhibits human pancreatic carcinomas in vitro and in vivo

Huang, H. L., Chao, M. W., Chen, C. C., Cheng, C. C., Chen, M. C., Lin, C. F., Liou, J. P., Teng, C. M. & Pan, S. L., Jun 9 2016, In : Scientific Reports. 6, 27794.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Methyl Protodioscin, a Steroidal Saponin, Inhibits Neointima Formation in Vitro and in Vivo

Chung, Y. L., Pan, C. H., Wang, C. C. N., Hsu, K. C., Sheu, M. J., Chen, H. F. & Wu, C. H., Jun 24 2016, In : Journal of Natural Products. 79, 6, p. 1635-1644 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
5 Citations (Scopus)

Novel histone deacetylase inhibitor MPT0G009 induces cell apoptosis and synergistic anticancer activity with tumor necrosis factor-related apoptosis-inducing ligand against human hepatocellular carcinoma

Chen, M-C., Huang, H-H., Lai, C-Y., Lin, Y-J., Liou, J-P., Lai, M-J., Li, Y-H., Teng, C-M. & Yang, C-R., Jan 5 2016, In : Oncotarget. 7, 1, p. 402-17 16 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Synthesis and biological evaluation of lovastatin-derived aliphatic hydroxamates that induce reactive oxygen species

Lin, R. K., Lin, Y. F., Hsu, M. J., Hsieh, C. L., Wang, C. Y., Huang, C. C. & Huang, W. J., 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 22, p. 5528-5533 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Synthesis of C-4-Substituted Steviol Derivatives and Their Inhibitory Effects against Hepatitis B Virus

Lin, S-J., Su, T. C., Chu, C. N., Chang, Y. C., Yang, L. M., Kuo, Y. C. & Huang, T. J., Dec 23 2016, In : Journal of Natural Products. 79, 12, p. 3057-3064 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Synthesis of Canthardin Sulfanilamides and Their Acid Anhydride Analogues via a Ring-Opening Reaction of Activated Aziridines and Their Associated Pharmacological Effects

Chiang, L-L., Tseng, I. J., Lin, P-Y., Sheu, S-Y., Lin, C. T., Hsieh, Y-H., Lin, Y-J., Chen, H-L. & Lin, M-H., 2016, In : Molecules. 21, 1, p. 100

Research output: Contribution to journalArticle

4 Citations (Scopus)

The clinical and biochemical characteristics associated with insulin resistance in non-obese young women

Wang, C. C., Chang, C. J. & Hsu, M. I., Mar 25 2016, (Accepted/In press) In : Gynecological Endocrinology. p. 1-5 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Using anti-poly(ethylene glycol) bioparticles for the quantitation of PEGylated nanoparticles

Hsieh, Y. C., Cheng, T. C., Wang, H. E., Li, J. J., Lin, W. W., Huang, C. C., Chuang, C. H., Wang, Y. T., Wang, J. Y., Roffler, S. R., Chuang, K-H. & Cheng, T. L., Dec 19 2016, In : Scientific Reports. 6, 39119.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2015

Anti-inflammatory effects of platelet biomaterials in a macrophage cellular model

Renn, T. Y., Kao, Y. H., Wang, C. C. & Burnouf, T., Aug 1 2015, In : Vox Sanguinis. 109, 2, p. 138-147 10 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Anti-restenotic roles of dihydroaustrasulfone alcohol involved in inhibiting PDGF-BB-stimulated proliferation and migration of vascular smooth muscle cells

Li, P. C., Sheu, M. J., Ma, W. F., Pan, C. H., Sheu, J. H. & Wu, C. H., May 1 2015, In : Marine Drugs. 13, 5, p. 3046-3060 15 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Arthropod steroid hormone (20-Hydroxyecdysone) suppresses IL-1β- induced catabolic gene expression in cartilage

Sheu, S. Y., Ho, S. R., Sun, J. S., Chen, C. Y. & Ke, C. J., Jan 24 2015, In : BMC Complementary and Alternative Medicine. 15, 1, 1.

Research output: Contribution to journalArticle

10 Citations (Scopus)
9 Citations (Scopus)

Effects of yam dioscorin interventions on improvements of the metabolic syndrome in high-fat diet-induced obese rats

Shih, S-L., Lin, Y-S., Lin, S-Y. & Hou, W-C., 2015, In : Botanical Studies. 56, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Establishment of a two-dimensional chiral HPLC system for the simultaneous detection of lactate and 3-hydroxybutyrate enantiomers in human clinical samples

Liu, S. L., Oyama, T., Miyoshi, Y., Sheu, S. Y., Mita, M., Ide, T., Lindner, W., Hamase, K. & Lee, J. A., Mar 16 2015, In : Journal of Pharmaceutical and Biomedical Analysis. 116, p. 80-85 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
15 Citations (Scopus)

K20E, an oxidative-coupling compound of methyl caffeate, exhibits anti-angiogenic activities through down-regulations of VEGF and VEGF receptor-2

Pan, C. H., Lin, W. H., Chien, Y. C., Liu, F. C., Sheu, M. J., Kuo, Y. H. & Wu, C. H., Jan 5 2015, In : Toxicology and Applied Pharmacology. 282, 2, p. 215-226 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
1 Citation (Scopus)

Mitochondrial translocation of EGFR regulates mitochondria dynamics and promotes metastasis in NSCLC

Che, T. F., Lin, C. W., Wu, Y. Y., Chen, Y. J., Han, C. L., Chang, Y. L., Wu, C. T., Hsiao, T. H., Hong, T. M. & Yang, P. C., 2015, In : Oncotarget. 6, 35, p. 37349-37366 18 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
15 Citations (Scopus)

New whitening constituents from taiwan-native Pyracantha koidzumii: Structures and tyrosinase inhibitory analysis in human epidermalmelanocytes

Lin, R. D., Chen, M. C., Liu, Y. L., Lin, Y. T., Lu, M. K., Hsu, F-L. & Lee, M. H., Dec 2 2015, In : International Journal of Molecular Sciences. 16, 12, p. 28598-28613 16 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling

Lai, M-J., Lee, H. Y., Chuang, H-Y., Chang, L-H., Tsai, A-C., Chen, M. C., Huang, H-L., Wu, Y-W., Teng, C-M., Pan, S. L., Liu, Y-M., Mehndiratta, S. & Liou, J. P., Aug 27 2015, In : Journal of Medicinal Chemistry. 58, 16, p. 6549-6558 10 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Pb2+ induces gastrin gene expression by extracellular signal-regulated kinases 1/2 and transcription factor activator protein 1 in human gastric carcinoma cells

Chan, C. P., Tsai, Y. T., Chen, Y. L., Hsu, Y. W., Tseng, J. T., Chuang, H. Y., Shiurba, R., Lee, M. H., Wang, J. Y. & Chang, W. C., Feb 1 2015, In : Environmental Toxicology. 30, 2, p. 129-136 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Pyrimidinedione-mediated selective histone deacetylase 6 inhibitors with antitumor activity in colorectal cancer HCT116 cells

Liu, Y-M., Lee, H. Y., Lai, M-J., Pan, S. L., Huang, H-L., Kuo, F-C., Chen, M. C. & Liou, J. P., Aug 17 2015, In : Organic and Biomolecular Chemistry. 13, 40, p. 10226-10235 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Radix Scrophulariae extracts (harpagoside) suppresses hypoxia-induced microglial activation and neurotoxicity

Sheu, S. Y., Hong, Y. W., Sun, J. S., Liu, M. H., Chen, C. Y. & Ke, C. J., Sep 14 2015, In : BMC Complementary and Alternative Medicine. 15, 1, 324.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Redox reaction mediated direct synthesis of hierarchical flower-like CuO spheres anchored on electrospun poly(vinylidene difluoride) fiber surfaces at low temperatures

Lee, Y. Y., Li, H. Y., Chiu, S. J., Liang, W. L., Yeh, P. L. & Liu, Y. L., 2015, In : RSC Advances. 5, 121, p. 100228-100234 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

The novel ribonucleotide reductase inhibitor COH29 inhibits DNA repair in vitros

Chen, M. C., Zhou, B., Zhang, K., Yuan, Y. C., Un, F., Hu, S., Chou, C. M., Chen, C. H., Wu, J., Wang, Y., Liu, X., Smith, D. L., Li, H., Liu, Z., Warden, C. D., Su, L., Malkas, L. H., Chung, Y. M., Hu, M. C. T. & Yen, Y., Jun 1 2015, In : Molecular Pharmacology. 87, 6, p. 996-1005 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
31 Citations (Scopus)
2014

Adjunctive traditional Chinese medicine therapy improves survival in patients with advanced breast cancer: A population-based study

Lee, Y-W., Chen, T-L., Shih, Y. R. V., Tsai, C. L., Chang, C-C., Liang, H-H., Tseng, S-H., Chien, S-C. & Wang, C-C., May 1 2014, In : Cancer. 120, 9, p. 1338-1344 7 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Anti-inflammatory effects of vitis thunbergii var. taiwaniana on knee damage associated with arthritis

Tsai, C. F., Wang, K. T., Chen, L. G., Lee, C. J., Tseng, S. H. & Wang, C. C., Apr 1 2014, In : Journal of Medicinal Food. 17, 4, p. 479-486 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro

Chin, Y. T., Hsieh, M. T., Yang, S. H., Tsai, P. W., Wang, S. H., Wang, C. C., Lee, Y. S., Cheng, G. Y., HuangFu, W. C., London, D., Tang, H. Y., Fu, E., Yen, Y., Liu, L. F., Lin, H. Y. & Davis, P. J., 2014, In : Oncotarget. 5, 24, p. 12891-12907 17 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells

Lee, H. Y., Tsai, A. C., Chen, M. C., Shen, P. J., Cheng, Y. C., Kuo, C. C., Pan, S. L., Liu, Y. M., Liu, J. F., Yeh, T. K., Wang, J. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., May 22 2014, In : Journal of Medicinal Chemistry. 57, 10, p. 4009-4022 14 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Comparison of chemical compositions and osteoprotective effects of different sections of velvet antler

Tseng, S. H., Sung, C. H., Chen, L. G., Lai, Y. J., Chang, W. S., Sung, H. C. & Wang, C. C., Jan 10 2014, In : Journal of Ethnopharmacology. 151, 1, p. 352-360 9 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)