Ph. D. Program in the Clinical Drug Development of Herbal Medicine

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1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

2,3,5,4′-tetrahydroxystilbene-2-O- β -glucoside isolated from Polygoni Multiflori ameliorates the development of periodontitis

Chin, Y. T., Hsieh, M. T., Lin, C. Y., Kuo, P. J., Yang, Y. C. S. H., Shih, Y. J., Lai, H. Y., Cheng, G. Y., Tang, H. Y., Lee, C. C., Lee, S. Y., Wang, C. C., Lin, H. Y., Fu, E., Whang-Peng, J. & Liu, L. F., 2016, In : Mediators of Inflammation. 2016, 6953459.

Research output: Contribution to journalArticle

12 Citations (Scopus)

4-O-Caffeoylquinic acid as an antioxidant marker for mulberry leaves rich in phenolic compounds

Ganzon, J. G., Chen, L. G. & Wang, C. C., 2018, In : Journal of Food and Drug Analysis.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Active constituents from Sophora japonica exhibiting cellular tyrosinase inhibition in human epidermal melanocytes

Lo, Y. H., Lin, R. D., Lin, Y. P., Liu, Y. L. & Lee, M. H., Jul 30 2009, In : Journal of Ethnopharmacology. 124, 3, p. 625-629 5 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Activity staining of isocitrate lyase after electrophoresis on either native or sodium dodecyl sulfate polyacrylamide gels

Hou, W. C., Chen, H. J., Lin, Y. H., Chen, Y. C., Yang, L-L. & Lee, M. H., 2001, In : Electrophoresis. 22, 13, p. 2653-2655 3 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Activity staining of plasma amine oxidase after polyacrylamide gel electrophoresis and its application to natural inhibiro screening

Lee, M. H., Chuang, M. T. & Hou, W. C., Aug 2002, In : Electrophoresis. 23, 15, p. 2369-2372 4 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Adjunctive traditional Chinese medicine therapy improves survival in patients with advanced breast cancer: A population-based study

Lee, Y-W., Chen, T-L., Shih, Y. R. V., Tsai, C. L., Chang, C-C., Liang, H-H., Tseng, S-H., Chien, S-C. & Wang, C-C., May 1 2014, In : Cancer. 120, 9, p. 1338-1344 7 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Alteration of mesenchymal stem cells polarity by laminar shear stimulation promoting β-catenin nuclear localization

Chen, W-T., Hsu, W-T., Yen, M-H., Changou, C. A., Han, C-L., Chen, Y-J., Cheng, J-Y., Chang, T-H., Lee, O. K-S. & Ho, J. H-C., Jan 1 2019, In : Biomaterials. 190-191, p. 1-10 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Analysis of the sesquiterpenoids in processed atractylodis rhizoma

Wang, K. T., Chen, L. G., Yang, L-L., Ke, W. M., Chang, H. C. & Wang, C. C., Jan 2007, In : Chemical and Pharmaceutical Bulletin. 55, 1, p. 50-56 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

An in vivo molecular response analysis of colorectal cancer treated with Astragalus membranaceus extract

Tseng, A., Yang, C. H., Chen, C. H., Chen, C. H., Hsu, S. L., Lee, M. H., Lee, H. C. & Su, L. J., Feb 1 2016, In : Oncology Reports. 35, 2, p. 659-668 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

A novel prenylated C6-C3 compound with estrogen-like activity from the fruits of Illicium arborescens

Liaw, C. C., Chen, Y. C., Fazary, A. E., Hsieh, J. L., Chen, S. Y., Chien, C. T., Sheu, S. Y., Kuo, Y. H., Chiang, B. L. & Shen, Y. C., 2013, In : Phytochemistry Letters. 6, 3, p. 397-402 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Antibacterial and cytotoxic activities of different wild bitter gourd cultivars (Momordica charantia L. var. abbreviata Seringe)

Lu, Y. L., Liu, Y. H., Liang, W. L., Chuang, J. H., Cheng, K. T., Liang, H. J. & Hou, W. C., Oct 2011, In : Botanical Studies. 52, 4, p. 427-434 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Anti-inflammatory activity of mangostins from Garcinia mangostana

Chen, L. G., Yang, L-L. & Wang, C. C., Feb 2008, In : Food and Chemical Toxicology. 46, 2, p. 688-693 6 p.

Research output: Contribution to journalArticle

263 Citations (Scopus)

Anti-inflammatory and Antinociceptive Constituents of Atractylodes japonica Koidzumi

Chen, L. G., Jan, Y. S., Tsai, P. W., Norimoto, H., Michihara, S., Murayama, C. & Wang, C. C., Mar 23 2016, In : Journal of Agricultural and Food Chemistry. 64, 11, p. 2254-2262 9 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Anti-inflammatory and free radial scavenging activities of the constituents isolated from machilus zuihoensis

Mao, Y. W., Tseng, H. W., Liang, W. L., Chen, I. S., Chen, S. T. & Lee, M. H., Nov 2011, In : Molecules. 16, 11, p. 9451-9466 16 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Anti-inflammatory constituents of Zingiber zerumbet

Chien, T. Y., Chen, L. G., Lee, C. J., Lee, F. Y. & Wang, C. C., Oct 1 2008, In : Food Chemistry. 110, 3, p. 584-589 6 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Anti-inflammatory effects of daidzein on primary astroglial cell culture

Liu, M. H., Lin, Y. S., Sheu, S. Y. & Sun, J. S., Jun 1 2009, In : Nutritional Neuroscience. 12, 3, p. 123-134 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Anti-inflammatory effects of indomethacin's methyl ester derivative and induction of apoptosis in HL-60 cells

Chao, S. H., Wu, A-B., Lee, C. J., Chen, F. A. & Wang, C. C., Dec 2005, In : Biological and Pharmaceutical Bulletin. 28, 12, p. 2206-2210 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Anti-inflammatory effects of platelet biomaterials in a macrophage cellular model

Renn, T. Y., Kao, Y. H., Wang, C. C. & Burnouf, T., Aug 1 2015, In : Vox Sanguinis. 109, 2, p. 138-147 10 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Anti-inflammatory effects of Punica granatum Linne in vitro and in vivo

Lee, C. J., Chen, L. G., Liang, W. L. & Wang, C. C., Jan 15 2010, In : Food Chemistry. 118, 2, p. 315-322 8 p.

Research output: Contribution to journalArticle

128 Citations (Scopus)

Anti-inflammatory effects of resveratrol and oligostilbenes from vitis thunbergii var. taiwaniana against lipopolysaccharide-induced arthritis

Wang, K. T., Chen, L. G., Tseng, S. H., Huang, J. S., Hsieh, M-S. & Wang, C. C., Apr 27 2011, In : Journal of Agricultural and Food Chemistry. 59, 8, p. 3649-3656 8 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Anti-inflammatory effects of vitis thunbergii var. taiwaniana on knee damage associated with arthritis

Tsai, C. F., Wang, K. T., Chen, L. G., Lee, C. J., Tseng, S. H. & Wang, C. C., Apr 1 2014, In : Journal of Medicinal Food. 17, 4, p. 479-486 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
40 Citations (Scopus)

Antinociceptive and anti-inflammatory effects of zerumbone against mono-iodoacetate-induced arthritis

Chien, T. Y., Huang, S. K. H., Lee, C. J., Tsai, P. W. & Wang, C. C., Feb 1 2016, In : International Journal of Molecular Sciences. 17, 2, 249.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Antiobesity and antihyperlipidaemic effects of Yan-Sheng-Yin in animals and humans

Wu, C. H., Pan, C. H., Lee, C. K., Sheu, M. J., Liu, F. C., Wang, G. J. & Wu, C. H., Jun 1 2016, In : Journal of Functional Foods. 24, p. 173-182 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
89 Citations (Scopus)

Antioxidant activities of different wild bitter gourd (Momordica charantia l. var. abbreviata seringe) cultivars

Lu, Y. L., Liu, Y. H., Chyuan, J. H., Cheng, K. T., Liang, W. L. & Hou, W. C., Apr 2012, In : Botanical Studies. 53, 2, p. 207-214 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Antioxidant activities of dioscorin, the storage protein of yam (Dioscorea batatas Decne) tuber

Hou, W. C., Lee, M. H., Chen, H. J., Liang, W. L., Han, C. H., Liu, Y. W. & Lin, Y. H., 2001, In : Journal of Agricultural and Food Chemistry. 49, 10, p. 4956-4960 5 p.

Research output: Contribution to journalArticle

151 Citations (Scopus)
72 Citations (Scopus)

Antioxidant and heme oxygenase-1 (HO-1)-induced effects of selected Taiwanese plants

Lee, M. H., Jiang, C. B., Juan, S. H., Lin, R. D. & Hou, W. C., Feb 2006, In : Fitoterapia. 77, 2, p. 109-115 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Antioxidant and semicarbazide-sensitive amine oxidase inhibitory activities of glucuronic acid hydroxamate

Liu, Y. H., Liang, W. L., Lee, C. C., Tsai, Y. F. & Hou, W. C., Nov 15 2011, In : Food Chemistry. 129, 2, p. 423-428 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Anti-oxidative abilities of essential oils from atractylodes ovata rhizome

Wang, C. C., Wang, K. T., Chen, L. G., Chou, D. S. & Liang, W. L., 2011, In : Evidence-based Complementary and Alternative Medicine. 2011, 204892.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro

Chin, Y. T., Hsieh, M. T., Yang, S. H., Tsai, P. W., Wang, S. H., Wang, C. C., Lee, Y. S., Cheng, G. Y., HuangFu, W. C., London, D., Tang, H. Y., Fu, E., Yen, Y., Liu, L. F., Lin, H. Y. & Davis, P. J., 2014, In : Oncotarget. 5, 24, p. 12891-12907 17 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Anti-restenotic roles of dihydroaustrasulfone alcohol involved in inhibiting PDGF-BB-stimulated proliferation and migration of vascular smooth muscle cells

Li, P. C., Sheu, M. J., Ma, W. F., Pan, C. H., Sheu, J. H. & Wu, C. H., May 1 2015, In : Marine Drugs. 13, 5, p. 3046-3060 15 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Antitumor activities of ellagitannins on tumor cell lines.

Yang, L-L., Wang, C. C., Yen, K. Y., Yoshida, T., Hatano, T. & Okuda, T., 1999, In : Basic Life Sciences. 66, p. 615-628 14 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Antitumor effects of osthol from Cnidium monnieri: An in vitro and in vivo study

Chou, S-Y., Hsu, C-S., Wang, K. T., Wang, M. C. & Wang, C. C., Mar 2007, In : Phytotherapy Research. 21, 3, p. 226-230 5 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)

Antitumor effects of zerumbone from Zingiber zerumbet in P-388D1 cells in vitro and in vivo

Huang, G. C., Chien, T. Y., Chen, L. G. & Wang, C. C., Mar 2005, In : Planta Medica. 71, 3, p. 219-224 6 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Antitumor principle constituents of Myrica rubra var. acuminata

Yang, L-L., Chang, C. C., Chen, L. G. & Wang, C. C., May 7 2003, In : Journal of Agricultural and Food Chemistry. 51, 10, p. 2974-2979 6 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Arthropod steroid hormone (20-Hydroxyecdysone) suppresses IL-1β- induced catabolic gene expression in cartilage

Sheu, S. Y., Ho, S. R., Sun, J. S., Chen, C. Y. & Ke, C. J., Jan 24 2015, In : BMC Complementary and Alternative Medicine. 15, 1, 1.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and Akt activation in non-small cell lung cancer cells

Tsai, M. H., Liu, J. F., Chiang, Y. C., Hu, S. C. S., Hsu, L. F., Lin, Y. C., Lin, Z. C., Lee, H. C., Chen, M. C., Huang, C. L. & Lee, C. W., 2017, In : Oncotarget. 8, 17, p. 28342-28358 17 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
8 Citations (Scopus)

Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells

Lee, H. Y., Tsai, A. C., Chen, M. C., Shen, P. J., Cheng, Y. C., Kuo, C. C., Pan, S. L., Liu, Y. M., Liu, J. F., Yeh, T. K., Wang, J. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., May 22 2014, In : Journal of Medicinal Chemistry. 57, 10, p. 4009-4022 14 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Aza-PBHA, a potent histone deacetylase inhibitor, inhibits human gastric-cancer cell migration via PKCα-mediated AHR-HDAC interactions

Tsai, C. H., Li, C. H., Liao, P. L., Chang, Y. W., Cheng, Y. W. & Kang, J. J., Feb 2020, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1867, 2, 118564.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Benzophenones as xanthine oxidase inhibitors

Sheu, S. Y., Tsai, H. J. & Chiang, H. C., 1999, In : Anticancer Research. 19, 2 A, p. 1131-1135 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Bioactive constituents of Spatholobus suberectus in regulating tyrosinase-related proteins and mRNA in HEMn cells

Lee, M. H., Lin, Y. P., Hsu, F-L., Zhan, G. R. & Yen, K. Y., Jun 2006, In : Phytochemistry. 67, 12, p. 1262-1270 9 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

Bioassay-guided isolation and HPLC quantification of antiproliferative metabolites from Stahlianthus thorelii

Nguyen, N. L., Vo, T. H., Lin, Y. C., Liaw, C. C., Lin, Z. H., Chen, M. C. & Kuo, Y. H., Jan 28 2020, In : Molecules. 25, 3, 551.

Research output: Contribution to journalArticle

Open Access

Biological characterization of oxidized hyaluronic acid/resveratrol hydrogel for cartilage tissue engineering

Sheu, S. Y., Chen, W. S., Sun, J. S., Lin, F. H. & Wu, T., Dec 2013, In : Journal of Biomedical Materials Research - Part A. 101, 12, p. 3457-3466 10 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Biotransformation of dihydroisosteviol and the effects of transformed products on steroidogenic gene expressions

Chang, S. F., Yang, L. M., Huang, T. J., Chen, C. Y., Sheu, S. Y., Liu, P. C. & Lin, S. J., Nov 2013, In : Phytochemistry. 95, p. 268-276 9 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Building a web-based e-learning model for preventing club drug abuse

Li, Y. C., Tsai, W. C., Huang, C. Y., Hu, C. M., Wang, C. C., Chen, J. L. & Hsu, C-Y., Feb 1 2006, In : Journal on Information Technology in Healthcare. 4, 1, p. 38-48 11 p.

Research output: Contribution to journalArticle