Ph. D. Program in the Clinical Drug Development of Herbal Medicine

Research Output

2011

Icariin inhibits osteoclast differentiation and bone resorption by suppression of MAPKs/NF-κB regulated HIF-1α and PGE2 synthesis

Hsieh, T. P., Sheu, S. Y., Sun, J. S. & Chen, M. H., Jan 15 2011, In : Phytomedicine. 18, 2-3, p. 176-185 10 p.

Research output: Contribution to journalArticle

127 Citations (Scopus)

Protective effect of dried safflower petal aqueous extract and its main constituent, carthamus yellow, against lipopolysaccharide-induced inflammation in RAW264.7 macrophages

Wang, C. C., Choy, C-S., Liu, Y. H., Cheah, K. P., Li, J. S., Wang, J. T. J., Yu, W. Y., Lin, C-W., Cheng, H. W. & Hu, C-M., Jan 30 2011, In : Journal of the Science of Food and Agriculture. 91, 2, p. 218-225 8 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

The correlation between skin-care effects and phytochemical contents in Lamiaceae plants

Lee, C. J., Chen, L. G., Chang, T. L., Ke, W. M., Lo, Y. F. & Wang, C. C., Feb 2011, In : Food Chemistry. 124, 3, p. 833-841 9 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

The immuno-regulatory effects of Schisandra chinensis and its constituents on human monocytic leukemia cells

Lin, R. D., Mao, Y. W., Leu, S. J., Huang, C. Y. & Lee, M. H., Jun 2011, In : Molecules. 16, 6, p. 4836-4849 14 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

The protective effects of coumestrol against amyloid-beta peptide- and lipopolysaccharide-induced toxicity on mice astrocytes

Liu, M. H., Tsuang, F. Y., Sheu, S. Y., Sun, J. S. & Shih, C. M., Jul 2011, In : Neurological Research. 33, 6, p. 663-672 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
15 Citations (Scopus)
2010

Anti-inflammatory effects of Punica granatum Linne in vitro and in vivo

Lee, C. J., Chen, L. G., Liang, W. L. & Wang, C. C., Jan 15 2010, In : Food Chemistry. 118, 2, p. 315-322 8 p.

Research output: Contribution to journalArticle

136 Citations (Scopus)

Cytotoxic constituents of Hydrangea angustipetala on human gastric carcinoma cells

Hsieh, C. R., Yu, P. J., Chen, L. G., Chaw, S. M., Chang, C. C. & Wang, C. C., Jan 2010, In : Botanical Studies. 51, 1, p. 45-51 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Gastroprotective activity of atractylenolide III from Atractylodes ovata on ethanol-induced gastric ulcer in vitro and in vivo

Wang, K. T., Chen, L. G., Wu, C. H., Chang, C. C. & Wang, C. C., Mar 2010, In : Journal of Pharmacy and Pharmacology. 62, 3, p. 381-388 8 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Ghrelin improves lps-induced gastrointestinal motility disturbances: Roles of no and prostaglandin E2

Chen, Y. T., Tsai, S. H., Sheu, S. Y. & Tsai, L-H., Feb 2010, In : Shock. 33, 2, p. 205-212 8 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Icariin isolated from Epimedium pubescens regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfa1 expression

Hsieh, T. P., Sheu, S. Y., Sun, J. S., Chen, M. H. & Liu, M. H., May 2010, In : Phytomedicine. 17, 6, p. 414-423 10 p.

Research output: Contribution to journalArticle

128 Citations (Scopus)

Icariin protects murine chondrocytes from lipopolysaccharide-induced inflammatory responses and extracellular matrix degradation

Liu, M. H., Sun, J. S., Tsai, S. W., Sheu, S. Y. & Chen, M. H., Jan 2010, In : Nutrition Research. 30, 1, p. 57-65 9 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Illicaborins A-C, three prenylated C6-C3 compounds from the fruits of Illicium arborescens

Lin, Y. X., Fazary, A. E., Chen, S. Y., Chien, C. T., Kuo, Y. H., Sheu, S. Y. & Shen, Y. C., Dec 2010, In : Food Chemistry. 123, 4, p. 1105-1111 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Neurocytoprotective effects of the bioactive constituents of Pueraria thomsonii in 6-hydroxydopamine (6-OHDA)-treated nerve growth factor (NGF)-differentiated PC12 cells

Lin, C. M., Lin, R. D., Chen, S. T., Lin, Y. P., Chiu, W. T., Lin, J. W., Hsu, F. L. & Lee, M. H., Dec 2010, In : Phytochemistry. 71, 17-18, p. 2147-2156 10 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Regulation of cytokine production by treating with Chinese tonic herbs in human peripheral blood mononuclear and human acute monocytic leukemia cells

Shin, H. Y., Kuo, Y. C., Hsu, F-L., Mao, Y. W. & Lee, M. H., Dec 2010, In : Journal of Food and Drug Analysis. 18, 6, p. 414-424 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Study of the natural product intermediates of steviolbioside, steviol, and isosteviol; O- and N-acylated forms of benzotriazoyl esters

Lee, L. W., Chen, S. M., Lin, C. C., Sheu, S. Y. & Lin, P. Y., 2010, In : Journal of the Chinese Chemical Society. 57, 6, p. 1232-1236 5 p.

Research output: Contribution to journalArticle

2009

Active constituents from Sophora japonica exhibiting cellular tyrosinase inhibition in human epidermal melanocytes

Lo, Y. H., Lin, R. D., Lin, Y. P., Liu, Y. L. & Lee, M. H., Jul 30 2009, In : Journal of Ethnopharmacology. 124, 3, p. 625-629 5 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Anti-inflammatory effects of daidzein on primary astroglial cell culture

Liu, M. H., Lin, Y. S., Sheu, S. Y. & Sun, J. S., Jun 1 2009, In : Nutritional Neuroscience. 12, 3, p. 123-134 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Effects of burdock extract preparation on gastric mucosal protection

Chen, F. A., Lee, S. C., Chao, H. R., Fu, W. C., Hsu, M. C., Horng, C. T., Wang, C. C., Matsui, H. & Agoramoorthy, G., Apr 2009, In : Asian Journal of Chemistry. 21, 4, p. 3015-3022 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Ellagitannins from Terminalia calamansanai induced apoptosis in HL-60 cells

Chen, L. G., Huang, W. T., Lee, L. T. & Wang, C. C., Jun 2009, In : Toxicology in Vitro. 23, 4, p. 603-609 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Melanogenesis inhibition by gallotannins from Chinese galls in B16 mouse melanoma cells

Chen, L. G., Chang, W. L., Lee, C. J., Lee, L. T., Shih, C. M. & Wang, C. C., Aug 2009, In : Biological and Pharmaceutical Bulletin. 32, 8, p. 1447-1452 6 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Neural cell protective compounds isolated from Phoenix hanceana var. formosana

Lin, Y. P., Chen, T. Y., Tseng, H. W., Lee, M. H. & Chen, S. T., Jun 2009, In : Phytochemistry. 70, 9, p. 1173-1181 9 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)
25 Citations (Scopus)

Taiwanese native plants inhibit matrix metalloproteinase-9 activity after ultraviolet B irradiation

Lee, Y. L., Lee, M. H., Chang, H. J., Huang, P. Y., Huang, I. J., Cheng, K. T. & Leu, S. J., Mar 2009, In : Molecules. 14, 3, p. 1062-1071 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2008

Anti-inflammatory activity of mangostins from Garcinia mangostana

Chen, L. G., Yang, L-L. & Wang, C. C., Feb 2008, In : Food and Chemical Toxicology. 46, 2, p. 688-693 6 p.

Research output: Contribution to journalArticle

281 Citations (Scopus)

Anti-inflammatory constituents of Zingiber zerumbet

Chien, T. Y., Chen, L. G., Lee, C. J., Lee, F. Y. & Wang, C. C., Oct 1 2008, In : Food Chemistry. 110, 3, p. 584-589 6 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)
97 Citations (Scopus)

Characterizing the lipid-lowering effects and antioxidant mechanisms of tomato paste

Hsu, Y. M., Lai, C. H., Chang, C. Y., Fan, C. T., Chen, C. T. & Wu, C. H., 2008, In : Bioscience, Biotechnology and Biochemistry. 72, 3, p. 677-685 9 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

The effect of Chinese herbal medicines on TNF-α induced matrix metalloproteinase-1, -9 activities and interleukin-8 secretion

Lee, M. H., Yang, Y. Y., Tsai, Y-H., Lee, Y. L., Huang, P. Y., Huang, I. J., Cheng, K. T. & Leu, S. J., Oct 2008, In : Botanical Studies. 49, 4, p. 301-309 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
22 Citations (Scopus)

中醫藥基因體研究及其核心技術訓練(三)研習會專題集錦:

Translated title of the contribution: Genomics approach to Chinese medicine and core technology training course (III) designated treasury 林宜信, Hsu, F-L. & Lee, M-H., 2008, 行政院衛生署中醫藥委員會. 230 p. (中醫藥基因體教育訓練系列叢書)

Research output: Book/ReportBook

2007

Analysis of the sesquiterpenoids in processed atractylodis rhizoma

Wang, K. T., Chen, L. G., Yang, L-L., Ke, W. M., Chang, H. C. & Wang, C. C., Jan 2007, In : Chemical and Pharmaceutical Bulletin. 55, 1, p. 50-56 7 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Antitumor effects of osthol from Cnidium monnieri: An in vitro and in vivo study

Chou, S-Y., Hsu, C-S., Wang, K. T., Wang, M. C. & Wang, C. C., Mar 2007, In : Phytotherapy Research. 21, 3, p. 226-230 5 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)

Effects of coumestrol on neonatal and adult mice osteoblasts activities

Sun, J. S., Li, Y. Y., Liu, M. H. & Sheu, S. Y., Apr 2007, In : Journal of Biomedical Materials Research - Part A. 81, 1, p. 214-223 10 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Immuno-enhancement effects of Huang Qi Liu Yi Tang in a murine model of cyclophosphamide-induced leucopenia

Huang, G. C., Wu, L. S., Chen, L. G., Yang, L-L. & Wang, C. C., Jan 19 2007, In : Journal of Ethnopharmacology. 109, 2, p. 229-235 7 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
21 Citations (Scopus)

Prevention of hepatic oxidative injury by Xiao-Chen-Chi-Tang in mice

Tseng, S. H., Chien, T. Y., Tzeng, C. F., Lin, Y. H., Wu, C. H. & Wang, C. C., May 4 2007, In : Journal of Ethnopharmacology. 111, 2, p. 232-239 8 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

中醫藥基因體研究及其核心技術訓練(二)研習會精要彙編

Translated title of the contribution: Genomics approach to Chinese medicine and core technology training course. II, Thesaurus林宜信, Hsu, F-L. & Lee, M-H., 2007, 行政院衛生署中醫藥委員會. 210 p.

Research output: Book/ReportBook

2006

Antioxidant and heme oxygenase-1 (HO-1)-induced effects of selected Taiwanese plants

Lee, M. H., Jiang, C. B., Juan, S. H., Lin, R. D. & Hou, W. C., Feb 2006, In : Fitoterapia. 77, 2, p. 109-115 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Bioactive constituents of Spatholobus suberectus in regulating tyrosinase-related proteins and mRNA in HEMn cells

Lee, M. H., Lin, Y. P., Hsu, F-L., Zhan, G. R. & Yen, K. Y., Jun 2006, In : Phytochemistry. 67, 12, p. 1262-1270 9 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

Building a web-based e-learning model for preventing club drug abuse

Li, Y. C., Tsai, W. C., Huang, C. Y., Hu, C. M., Wang, C. C., Chen, J. L. & Hsu, C-Y., Feb 1 2006, In : Journal on Information Technology in Healthcare. 4, 1, p. 38-48 11 p.

Research output: Contribution to journalArticle

Cantharidin-induced cytotoxicity and cyclooxygenase 2 expression in human bladder carcinoma cell line

Huan, S. K. H., Lee, H. H., Liu, D. Z., Wu, C. C. & Wang, C. C., Jun 1 2006, In : Toxicology. 223, 1-2, p. 136-143 8 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Cosmetic applications of selected traditional Chinese herbal medicines

Wang, K-H., Lin, R. D., Hsu, F-L., Huang, Y-H., Chang, H. C., Huang, C. Y. & Lee, M-H., Jul 19 2006, In : Journal of Ethnopharmacology. 106, 3, p. 353-359 7 p.

Research output: Contribution to journalArticle

146 Citations (Scopus)

Effects of three purgative decoctions on inflammatory mediators

Tseng, S. H., Lee, H. H., Chen, L. G., Wu, C. H. & Wang, C. C., Apr 21 2006, In : Journal of Ethnopharmacology. 105, 1-2, p. 118-124 7 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
71 Citations (Scopus)

Monitoring medical abortion using mifepristone/misoprostol combination with ultrasonogram and serum human chorionic gonadotropin

Chou, S-Y., Chen, C. Y., Chiang, H. K., Chow, P. K., Wang, C. C. & Hsu, C-S., Mar 2006, In : Taiwanese Journal of Obstetrics and Gynecology. 45, 1, p. 48-52 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Natural products of cosmetics: Analysis of extracts of plants endemic to Taiwan for the presence of tyrosinase-inhibitory, melanin-reducing, and free radical scavenging activities

Jiang, C. B., Chang, M. J., Wen, C. L., Lin, Y. P., Hsu, F-L. & Lee, M. H., Dec 2006, In : Journal of Food and Drug Analysis. 14, 4, p. 346-352 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Phenolic constituents of Malus doumeri var. formosana in the field of skin care

Leu, S. J., Lin, Y. P., Lin, R. D., Wen, C. L., Cheng, K. T., Hsu, F-L. & Lee, M. H., Apr 2006, In : Biological and Pharmaceutical Bulletin. 29, 4, p. 740-745 6 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Pro-oxidant and cytotoxic activities of atractylenolide I in human promyeloleukemic HL-60 cells

Wang, C. C., Lin, S. Y., Cheng, H. C. & Hou, W. C., Aug 2006, In : Food and Chemical Toxicology. 44, 8, p. 1308-1315 8 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
2005

Anti-inflammatory effects of indomethacin's methyl ester derivative and induction of apoptosis in HL-60 cells

Chao, S. H., Wu, A-B., Lee, C. J., Chen, F. A. & Wang, C. C., Dec 2005, In : Biological and Pharmaceutical Bulletin. 28, 12, p. 2206-2210 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)