Ph. D. Program in the Clinical Drug Development of Herbal Medicine

Research Output

2015

New whitening constituents from taiwan-native Pyracantha koidzumii: Structures and tyrosinase inhibitory analysis in human epidermalmelanocytes

Lin, R. D., Chen, M. C., Liu, Y. L., Lin, Y. T., Lu, M. K., Hsu, F-L. & Lee, M. H., Dec 2 2015, In : International Journal of Molecular Sciences. 16, 12, p. 28598-28613 16 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling

Lai, M-J., Lee, H. Y., Chuang, H-Y., Chang, L-H., Tsai, A-C., Chen, M. C., Huang, H-L., Wu, Y-W., Teng, C-M., Pan, S. L., Liu, Y-M., Mehndiratta, S. & Liou, J. P., Aug 27 2015, In : Journal of Medicinal Chemistry. 58, 16, p. 6549-6558 10 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Pb2+ induces gastrin gene expression by extracellular signal-regulated kinases 1/2 and transcription factor activator protein 1 in human gastric carcinoma cells

Chan, C. P., Tsai, Y. T., Chen, Y. L., Hsu, Y. W., Tseng, J. T., Chuang, H. Y., Shiurba, R., Lee, M. H., Wang, J. Y. & Chang, W. C., Feb 1 2015, In : Environmental Toxicology. 30, 2, p. 129-136 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
9 Citations (Scopus)

Radix Scrophulariae extracts (harpagoside) suppresses hypoxia-induced microglial activation and neurotoxicity

Sheu, S. Y., Hong, Y. W., Sun, J. S., Liu, M. H., Chen, C. Y. & Ke, C. J., Sep 14 2015, In : BMC Complementary and Alternative Medicine. 15, 1, 324.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Redox reaction mediated direct synthesis of hierarchical flower-like CuO spheres anchored on electrospun poly(vinylidene difluoride) fiber surfaces at low temperatures

Lee, Y. Y., Li, H. Y., Chiu, S. J., Liang, W. L., Yeh, P. L. & Liu, Y. L., 2015, In : RSC Advances. 5, 121, p. 100228-100234 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

The novel ribonucleotide reductase inhibitor COH29 inhibits DNA repair in vitros

Chen, M. C., Zhou, B., Zhang, K., Yuan, Y. C., Un, F., Hu, S., Chou, C. M., Chen, C. H., Wu, J., Wang, Y., Liu, X., Smith, D. L., Li, H., Liu, Z., Warden, C. D., Su, L., Malkas, L. H., Chung, Y. M., Hu, M. C. T. & Yen, Y., Jun 1 2015, In : Molecular Pharmacology. 87, 6, p. 996-1005 10 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
34 Citations (Scopus)
2014

Adjunctive traditional Chinese medicine therapy improves survival in patients with advanced breast cancer: A population-based study

Lee, Y-W., Chen, T-L., Shih, Y. R. V., Tsai, C. L., Chang, C-C., Liang, H-H., Tseng, S-H., Chien, S-C. & Wang, C-C., May 1 2014, In : Cancer. 120, 9, p. 1338-1344 7 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Anti-inflammatory effects of vitis thunbergii var. taiwaniana on knee damage associated with arthritis

Tsai, C. F., Wang, K. T., Chen, L. G., Lee, C. J., Tseng, S. H. & Wang, C. C., Apr 1 2014, In : Journal of Medicinal Food. 17, 4, p. 479-486 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro

Chin, Y. T., Hsieh, M. T., Yang, S. H., Tsai, P. W., Wang, S. H., Wang, C. C., Lee, Y. S., Cheng, G. Y., HuangFu, W. C., London, D., Tang, H. Y., Fu, E., Yen, Y., Liu, L. F., Lin, H. Y. & Davis, P. J., 2014, In : Oncotarget. 5, 24, p. 12891-12907 17 p.

Research output: Contribution to journalArticle

Open Access
46 Citations (Scopus)

Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells

Lee, H. Y., Tsai, A. C., Chen, M. C., Shen, P. J., Cheng, Y. C., Kuo, C. C., Pan, S. L., Liu, Y. M., Liu, J. F., Yeh, T. K., Wang, J. C., Chang, C. Y., Chang, J. Y. & Liou, J. P., May 22 2014, In : Journal of Medicinal Chemistry. 57, 10, p. 4009-4022 14 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Comparison of chemical compositions and osteoprotective effects of different sections of velvet antler

Tseng, S. H., Sung, C. H., Chen, L. G., Lai, Y. J., Chang, W. S., Sung, H. C. & Wang, C. C., Jan 10 2014, In : Journal of Ethnopharmacology. 151, 1, p. 352-360 9 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Deep sea water prevents balloon angioplasty-induced hyperplasia through MMP-2: An in vitro and in vivo study

Li, P. C., Pan, C. H., Sheu, M. J., Wu, C. C., Ma, W. F. & Wu, C. H., May 13 2014, In : PLoS One. 9, 5, e96927.

Research output: Contribution to journalArticle

19 Citations (Scopus)
13 Citations (Scopus)

NPRL-Z-1, as a new topoisomerase II poison, induces cell apoptosis and ROS generation in human renal carcinoma cells

Wu, S. Y., Pan, S. L., Xiao, Z. Y., Hsu, J. L., Chen, M. C., Lee, K. H. & Teng, C. M., Nov 5 2014, In : PLoS One. 9, 11, e112220.

Research output: Contribution to journalArticle

10 Citations (Scopus)

NSC746364, a G-quadruplex-stabilizing agent, suppresses cell growth of A549 human lung cancer cells through activation of the ATR/Chk1-dependent pathway

Chung, Y. L., Pan, C. H., Liou, W. H., Sheu, M. J., Lin, W. H., Chen, T. C., Huang, H. S. & Wu, C. H., 2014, In : Journal of Pharmacological Sciences. 124, 1, p. 7-17 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Osteoporosis is associated with antiepileptic drugs: A population-based study

Wu, F. J., Sheu, S. Y. & Lin, H. C., Sep 1 2014, In : Epileptic Disorders. 16, 3, p. 333-342 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Pharmacological effects of "Jutsu" (Atractylodis rhizome and Atractylodis lanceae rhizome) on 1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-Induced head twitch response in mice (I)

Murayama, C., Wang, C. C., Michihara, S. & Norimoto, H., Sep 18 2014, In : Molecules. 19, 9, p. 14979-14986 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Stimulation of osteogenic activity in human osteoblast cells by edible Uraria crinita

Mao, Y. W., Lin, R. D., Hung, H. C. & Lee, M. H., Jun 18 2014, In : Journal of Agricultural and Food Chemistry. 62, 24, p. 5581-5588 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2013

A novel prenylated C6-C3 compound with estrogen-like activity from the fruits of Illicium arborescens

Liaw, C. C., Chen, Y. C., Fazary, A. E., Hsieh, J. L., Chen, S. Y., Chien, C. T., Sheu, S. Y., Kuo, Y. H., Chiang, B. L. & Shen, Y. C., 2013, In : Phytochemistry Letters. 6, 3, p. 397-402 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Antihyperlipidemic and antioxidant effects of C-phycocyanin in golden syrian hamsters fed with a hypercholesterolemic diet

Sheu, M. J., Hsieh, Y. Y., Lai, C. H., Chang, C. C. & Wu, C. H., 2013, In : Journal of Traditional and Complementary Medicine. 3, 1, p. 41-47 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Biological characterization of oxidized hyaluronic acid/resveratrol hydrogel for cartilage tissue engineering

Sheu, S. Y., Chen, W. S., Sun, J. S., Lin, F. H. & Wu, T., Dec 2013, In : Journal of Biomedical Materials Research - Part A. 101, 12, p. 3457-3466 10 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Biotransformation of dihydroisosteviol and the effects of transformed products on steroidogenic gene expressions

Chang, S. F., Yang, L. M., Huang, T. J., Chen, C. Y., Sheu, S. Y., Liu, P. C. & Lin, S. J., Nov 2013, In : Phytochemistry. 95, p. 268-276 9 p.

Research output: Contribution to journalArticle

Chemical and pharmacological investigation of micropropagated Hygrophila pogonocalyx produced from leaf explants

Ho, C. W., Lin, R. D., Li, Z-H., Lin, C. H., Wen, C. L., Tseng, Y. T. & Lee, M. H., 2013, In : Botanical Studies. 54, 1, 51.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Correlations of the components of tea tree oil with its antibacterial effects and skin irritation

Lee, C. J., Chen, L. W., Chen, L. G., Chang, T. L., Huang, C. W., Huang, M. C. & Wang, C. C., Jun 2013, In : Journal of Food and Drug Analysis. 21, 2, p. 169-176 8 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Immunomodulatory effects of hedysarum polybotrys extract in mice macrophages, splenocytes and leucopenia

Huang, G. C., Lee, C. J., Wang, K. T., Weng, B. C., Chien, T. Y., Tseng, S. H. & Wang, C. C., Dec 2013, In : Molecules. 18, 12, p. 14862-14875 14 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Indomethacin inhibits cancer cell migration via attenuation of cellular calcium mobilization

Guo, Y. C., Chang, C. M., Hsu, W. L., Chiu, S. J., Tsai, Y. T., Chou, Y. H., Hou, M. F., Wang, J. Y., Lee, M. H., Tsai, K. L. & Chang, W. C., Jun 2013, In : Molecules. 18, 6, p. 6584-6596 13 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2012

Antioxidant activities of different wild bitter gourd (Momordica charantia l. var. abbreviata seringe) cultivars

Lu, Y. L., Liu, Y. H., Chyuan, J. H., Cheng, K. T., Liang, W. L. & Hou, W. C., Apr 2012, In : Botanical Studies. 53, 2, p. 207-214 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
8 Citations (Scopus)

Chemical and biological evaluation of nephrocizin in protecting nerve growth factor-differentiated PC12 cells by 6-hydroxydopamine-induced neurotoxicity

Lin, Y. P., Chen, T. Y., Tseng, H. W., Lee, M. H. & Chen, S. T., Dec 2012, In : Phytochemistry. 84, p. 102-115 14 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Effects of velvet antler with blood on bone in ovariectomized rats

Tseng, S. H., Sung, H. C., Chen, L. G., Lai, Y. J., Wang, K. T., Sung, C. H. & Wang, C. C., Sep 2012, In : Molecules. 17, 9, p. 10574-10585 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
21 Citations (Scopus)

Heptadecanols from the leaves of Persea americana var. americana

Li, Z-H., Tsai, Y. F., Huang, T. T., Chen, P. Y., Liang, W. L. & Lee, C. K., May 15 2012, In : Food Chemistry. 132, 2, p. 921-924 4 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Inhibitory effects of terpenoids from the fermented broth of the ascomycete stilbohypoxylon elaeicola YMJ173 on nitric oxide production in RAW264.7 macrophages

Wang, G. J., Liang, W. L., Ju, Y. M., Yang, W. B., Chang, Y. W. & Li, Z-H., Jan 2012, In : Chemistry and Biodiversity. 9, 1, p. 131-138 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Scutellaria baicalensis alleviates cantharidin-induced rat hemorrhagic cystitis through inhibition of cyclooxygenase-2 overexpression

Huan, S. K. H., Wang, K. T., Yeh, S. D., Lee, C. J., Lin, L. C., Liu, D. Z. & Wang, C. C., Jun 2012, In : Molecules. 17, 6, p. 6277-6289 13 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Stimulatory effect of puerarin on bone formation through co-activation of nitric oxide and bone morphogenetic protein-2/ mitogen-activated protein kinases pathways in mice

Sheu, S. Y., Tsai, C. C., Sun, J. S., Chen, M. H., Liu, M. H. & Sun, M. G., Oct 20 2012, In : Chinese Medical Journal. 125, 20, p. 3646-3653 8 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Synthesis and Evaluation of Cantharidinimides on Human Cancer Cells

Tseng, I. J., Sheu, S. Y., Lin, P. Y., Lee, J. A., Ou, K. L. & Lee, L. W., Oct 2012, In : Journal of Experimental and Clinical Medicine(Taiwan). 4, 5, p. 280-283 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The antinociceptive and anti-inflammatory activities of Petasites formosanus Kitamura extract

Lin, S. Y., Teng, H. L., Tseng, S. H., Chen, L. G. & Wang, C. C., Oct 2012, In : Botanical Studies. 53, 4, p. 431-438 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Wu-Chia-Pi solution attenuates carbon tetrachloride-induced hepatic injury through the antioxidative abilities of its components acteoside and quercetin

Huan, S. K. H., Wang, K. T., Lee, C. J., Sung, C. H., Chien, T. Y. & Wang, C. C., Dec 2012, In : Molecules. 17, 12, p. 14673-14684 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
33 Citations (Scopus)
2011

Antibacterial and cytotoxic activities of different wild bitter gourd cultivars (Momordica charantia L. var. abbreviata Seringe)

Lu, Y. L., Liu, Y. H., Liang, W. L., Chuang, J. H., Cheng, K. T., Liang, H. J. & Hou, W. C., Oct 2011, In : Botanical Studies. 52, 4, p. 427-434 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Anti-inflammatory and free radial scavenging activities of the constituents isolated from machilus zuihoensis

Mao, Y. W., Tseng, H. W., Liang, W. L., Chen, I. S., Chen, S. T. & Lee, M. H., Nov 2011, In : Molecules. 16, 11, p. 9451-9466 16 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Anti-inflammatory effects of resveratrol and oligostilbenes from vitis thunbergii var. taiwaniana against lipopolysaccharide-induced arthritis

Wang, K. T., Chen, L. G., Tseng, S. H., Huang, J. S., Hsieh, M-S. & Wang, C. C., Apr 27 2011, In : Journal of Agricultural and Food Chemistry. 59, 8, p. 3649-3656 8 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Antioxidant and semicarbazide-sensitive amine oxidase inhibitory activities of glucuronic acid hydroxamate

Liu, Y. H., Liang, W. L., Lee, C. C., Tsai, Y. F. & Hou, W. C., Nov 15 2011, In : Food Chemistry. 129, 2, p. 423-428 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Anti-oxidative abilities of essential oils from atractylodes ovata rhizome

Wang, C. C., Wang, K. T., Chen, L. G., Chou, D. S. & Liang, W. L., 2011, In : Evidence-based Complementary and Alternative Medicine. 2011, 204892.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Chemical constituents of the fermented broth of the ascomycete theissenia cinerea 89091602

Liang, W. L., Hsiao, C. J., Ju, Y. M., Lee, L. H. & Li, Z-H., Dec 2011, In : Chemistry and Biodiversity. 8, 12, p. 2285-2290 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Gastroprotective effects of Ping-Wei San on indomethacin-induced gastric ulcer

Tiong, C., Liang, W. L., Liu, H. Y., Wang, K. T., Chang, C. C. & Wang, C. C., Dec 2011, In : Journal of Food and Drug Analysis. 19, 4

Research output: Contribution to journalArticle

5 Citations (Scopus)

Hypolipidemic effects of three purgative decoctions

Wang, C. C., Tseng, S. H., Chien, T. Y., Chen, J. R. & Lin, I. H., 2011, In : Evidence-based Complementary and Alternative Medicine. 2011, 249254.

Research output: Contribution to journalArticle

8 Citations (Scopus)