Ph. D. Program in the Clinical Drug Development of Herbal Medicine

Research Output 1992 2020

2020

Aza-PBHA, a potent histone deacetylase inhibitor, inhibits human gastric-cancer cell migration via PKCα-mediated AHR-HDAC interactions

Tsai, C. H., Li, C. H., Liao, P. L., Chang, Y. W., Cheng, Y. W. & Kang, J. J., Feb 2020, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1867, 2, 118564.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Histone Deacetylase Inhibitors
Histone Deacetylases
Stomach Neoplasms
Cell Movement

In vitro and in vivo evaluation of the neuroprotective activity of Uncaria hirsuta Haviland

Lin, C. M., Lin, Y. T., Lee, T. L., Imtiyaz, Z., Hou, W. C. & Lee, M. H., Jan 2020, In : Journal of Food and Drug Analysis. 28, 1, p. 147-158 12 p.

Research output: Contribution to journalArticle

Open Access
Uncaria
neuroprotective effect
Inhibitory Concentration 50
inhibitory concentration 50
Oxidopamine
1 Citation (Scopus)

N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression

Mehndiratta, S., Lin, M. H., Wu, Y. W., Chen, C. H., Wu, T. Y., Chuang, K. H., Chao, M. W., Chen, Y. Y., Pan, S. L., Chen, M. C. & Liou, J. P., Jan 1 2020, In : European Journal of Medicinal Chemistry. 185, p. 111725 111725.

Research output: Contribution to journalArticle

Anilides
HSP90 Heat-Shock Proteins
Histone Deacetylase Inhibitors
Histone Deacetylases
Down-Regulation

Synthesis and biological evaluation of 2-quinolineacrylamides

Wang, S. W., Lin, M. H., Hsu, F. C., Chen, M. C., Liou, J. P., Liu, Y. T., Chen, S. S. & Lee, H. Y., Feb 1 2020, In : Bioorganic and Medicinal Chemistry. 28, 3, 115250.

Research output: Contribution to journalArticle

Protein Isoforms
HCT116 Cells
Ether
Western Blotting
A549 Cells
2019
5 Citations (Scopus)

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

Benzamides
Histone Deacetylases
Tubulin
Heterografts
Inhibitory Concentration 50
1 Citation (Scopus)

Alteration of mesenchymal stem cells polarity by laminar shear stimulation promoting β-catenin nuclear localization

Chen, W-T., Hsu, W-T., Yen, M-H., Changou, C. A., Han, C-L., Chen, Y-J., Cheng, J-Y., Chang, T-H., Lee, O. K-S. & Ho, J. H-C., Jan 1 2019, In : Biomaterials. 190-191, p. 1-10 10 p.

Research output: Contribution to journalArticle

Catenins
Cell Polarity
Stem cells
Mesenchymal Stromal Cells
Shear stress

Correction: Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and akt activation in non-small cell lung cancer cells (Oncotarget (2017) 8 (28342–28358) DOI: 10.18632/oncotarget.16058)

Tsai, M. H., Liu, J. F., Chiang, Y. C., Hu, S. C. S., Hsu, L. F., Lin, Y. C., Lin, Z. C., Lee, H. C., Chen, M. C., Huang, C. L. & Lee, C. W., May 1 2019, In : Oncotarget. 10, 36, 1 p.

Research output: Contribution to journalArticle

Open Access
Taiwan
Non-Small Cell Lung Carcinoma
Rehabilitation
Apoptosis
artocarpin flavonoid

Down-regulation of aryl hydrocarbon receptor intensifies carcinogen-induced retinal lesion via SOCS3-STAT3 signaling

Tsai, C. H., Lee, Y., Li, C. H., Cheng, Y. W. & Kang, J. J., Jan 1 2019, (Accepted/In press) In : Cell Biology and Toxicology.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
STAT3 Transcription Factor
Carcinogens
Down-Regulation
Cytokines
1 Citation (Scopus)

Elucidation of the Effects of Si-Wu Tang on Menstrual Disorder Patterns through Activation of Aromatase and Antioxidation

Huang, G. C., Tsai, Y. Z., Lee, C. J., Chang, H. Y. & Wang, C. C., Mar 6 2019, In : Evidence-based Complementary and Alternative Medicine. 2019, p. 4761651 8 p., 4761651.

Research output: Contribution to journalArticle

Open Access
Rehmannia
Aromatase
ferulic acid
Polyphenols
Estradiol
1 Citation (Scopus)

Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata

Chen, M. C., Wang, G. J., Kuo, Y. H., Chiang, Y. R., Cho, T. Y., Ju, Y. M. & Lee, T. H., Jan 1 2019, In : Journal of Food and Drug Analysis. 27, 1, p. 111-117 7 p.

Research output: Contribution to journalArticle

Open Access
Xylaria
Isoptera
termite mounds
Ethers
nitric oxide

Liposomal irinotecan for treatment of colorectal cancer in a preclinical model

Huang, J. R., Lee, M. H., Li, W. S. & Wu, H. C., Mar 1 2019, In : Cancers. 11, 3, 281.

Research output: Contribution to journalArticle

Open Access
irinotecan
Colorectal Neoplasms
Therapeutics
Gastrointestinal Contents
Open Access
Colorectal Neoplasms
Apoptosis
Ligands
Autophagy
Cell Death
Platelet-Derived Growth Factor beta Receptor
Cell Aging
Vascular Smooth Muscle
Smooth Muscle Myocytes
Cell Movement

Stability of Principal Hydrolysable Tannins from Trapa taiwanensis Hulls

Wang, C. C., Chen, H. F., Wu, J. Y. & Chen, L. G., Jan 21 2019, In : Molecules. 24, 2, 365.

Research output: Contribution to journalArticle

Open Access
Hydrolyzable Tannins
fluids
antioxidants
Fluids
buffers
1 Citation (Scopus)

The fungus-derived retinoprotectant theissenolactone C improves glaucoma-like injury mediated by MMP-9 inhibition

Lin, F. L., Cheng, Y. W., Yu, M., Ho, J. D., Kuo, Y. C., Chiou, G. C. Y., Chang, H. M., Lee, T. H. & Hsiao, G., Mar 15 2019, In : Phytomedicine. 56, p. 207-214 8 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Glaucoma
Reperfusion Injury
Interleukin-1
Chemokine CCL2

Transcriptomic and Proteomic Profiling of Human Mesenchymal Stem Cell Derived from Umbilical Cord in the Study of Preterm Birth

Chien, C. W., Lo, Y. S., Wu, H. Y., Hsuan, Y., Lin, C. K., Chen, Y. J., Lin, W. & Han, C. L., Jan 1 2019, (Accepted/In press) In : Proteomics - Clinical Applications. 1900024.

Research output: Contribution to journalArticle

Umbilical Cord
Premature Birth
Stem cells
Mesenchymal Stromal Cells
Proteomics
2018
5 Citations (Scopus)

4-O-Caffeoylquinic acid as an antioxidant marker for mulberry leaves rich in phenolic compounds

Ganzon, J. G., Chen, L. G. & Wang, C. C., 2018, In : Journal of Food and Drug Analysis.

Research output: Contribution to journalArticle

Morus
mulberries
phenolic compounds
Antioxidants
antioxidants

Bradycardia and hypotension from improper use of aconite root: A case report and brief review

Chou, P. Y., Wang, C. C., Tai, C. J., Yang, T. L. & Tang, Y. J., Oct 1 2018, In : Complementary Medicine Research. 25, 5, p. 338-343 6 p.

Research output: Contribution to journalReview article

Aconitum
Bradycardia
Hypotension
Herbal Medicine
Poisons
3 Citations (Scopus)

Chemotherapy Immunophenoprofiles in Non-Small-Cell Lung Cancer by Personalized Membrane Proteomics

Putri, D. U., Feng, P. H., Hsu, Y. H., Lee, K. Y., Jiang, F. W., Kuo, L. W., Chen, Y. J. & Han, C. L., Jan 1 2018, (Accepted/In press) In : Proteomics - Clinical Applications.

Research output: Contribution to journalArticle

Pemetrexed
Chemotherapy
Non-Small Cell Lung Carcinoma
Proteomics
Cisplatin
Technology
Adenocarcinoma of lung
Myeloid-Derived Suppressor Cells

Design of diarylheptanoid derivatives as dual inhibitors against class IIa histone deacetylase and β-amyloid aggregation

Chen, L. C., Tseng, H. J., Liu, C. Y., Huang, Y. Y., Yen, C. C., Weng, J. R., Lu, Y. L., Hou, W. C., Lin, T. E., Pan, I. H., Huang, K. K., Huang, W. J. & Hsu, K. C., Jul 3 2018, In : Frontiers in Pharmacology. 9, JUL, 708.

Research output: Contribution to journalArticle

Diarylheptanoids
Histone Deacetylases
Amyloid
Alzheimer Disease
Pyrogallol
3 Citations (Scopus)
pharmacokinetics
Hepatitis B virus
Pharmacokinetics
rats
Toll-Like Receptor 2
8 Citations (Scopus)

Discovery of aliphatic-chain hydroxamates containing indole derivatives with potent class I histone deacetylase inhibitory activities

Chao, S. W., Chen, L. C., Yu, C. C., Liu, C. Y., Lin, T. E., Guh, J. H., Wang, C. Y., Chen, C. Y., Hsu, K. C. & Huang, W. J., Jan 1 2018, In : European Journal of Medicinal Chemistry. 143, p. 792-805 14 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Derivatives
Carbon
Molecular Docking Simulation
Cutaneous T-Cell Lymphoma

Dose-dependent pharmacokinetics and tentative identification of urine metabolites from an isosteviol derivative with anti-hepatitis B activity in rats

Kachingwe, B. H., Wang, L-H., Uang, Y-S., Huang, T-J. & Lin, S-J., Sep 1 2018, In : Biomedical Chromatography. 32, 9, p. e4266 e4266.

Research output: Contribution to journalArticle

Pharmacokinetics
Metabolites
Hepatitis B
Rats
Urine

Erratum: Author Correction: Poly-protein G-expressing bacteria enhance the sensitivity of immunoassays (Scientific reports (2017) 7 1 (989))

Hao, W. R., Chen, M., Chen, Y. J., Su, Y. C., Cheng, C. M., Hsueh, H. Y., Kao, A. P., Hsieh, Y. C., Chang, J., Tseng, M. Y. & Chuang, K. H., Mar 6 2018, In : Scientific Reports. 8, 1, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Poly G
Immunoassay
Bacteria
Proteins

Genomic Alterations of Extrectra Cellular Genes as Diagnosis Markers for Head and Neck Squamous Cell Carcinoma

Yang, C-H., Lin, R-D., Lee, M-H., Tsai, M-H. & Su, L-J., 2018, In : International Journal of Head and Neck Science. 2, 1, p. 21-24 4 p.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Genes
Computational Biology
Squamous Cell Carcinoma
Public Health
2 Citations (Scopus)
Open Access
Oxidative Stress
Acetaminophen
Liver
Wounds and Injuries
Hep G2 Cells
2 Citations (Scopus)
Metoclopramide
Parkinsonian Disorders
Cohort Studies
Population
Health Insurance
1 Citation (Scopus)

Increased risk of a herpes zoster attack in patients receiving androgen deprivation therapy for prostate cancer

Wu, F. J., Kao, L. T., Sheu, S. Y., Lin, H. C. & Chung, S. D., Mar 1 2018, In : Andrologia. 50, 2, e12863.

Research output: Contribution to journalArticle

Herpes Zoster
Androgens
Prostatic Neoplasms
Therapeutics
Incidence
1 Citation (Scopus)

Inhibitory effects of punicalagin from Punica granatum against type II collagenase-induced osteoarthritis

Lee, C. J., Chen, L. G., Liang, W. L., Hsieh, M. S. & Wang, C. C., Feb 1 2018, In : Journal of Functional Foods. 41, p. 216-222 7 p.

Research output: Contribution to journalArticle

Punicaceae
Punica granatum
collagenase
chondrocytes
osteoarthritis
3 Citations (Scopus)

In vitro and in vivo anti-osteoarthritis effects of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside from Polygonum multiflorum

Tsai, P. W., Lee, Y. H., Chen, L. G., Lee, C. J. & Wang, C. C., Jan 1 2018, In : Molecules. 23, 3, 571.

Research output: Contribution to journalArticle

prostaglandins
glucosides
nitric oxide
Dinoprostone
Osteoarthritis
12 Citations (Scopus)

ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells

Chang, C. W., Chen, Y. S., Tsay, Y. G., Han, C. L., Chen, Y. J., Yang, C. C., Hung, K. F., Lin, C. H., Huang, T. Y., Kao, S. Y., Lee, T. C. & Lo, J. F., Feb 1 2018, In : Cell Death and Disease. 9, 2, 194.

Research output: Contribution to journalArticle

Neoplasms
Maintenance
Acetyl Coenzyme A
Citric Acid Cycle
Neoplastic Stem Cells
5 Citations (Scopus)

S100A9+ MDSC and TAM-mediated EGFR-TKI resistance in lung adenocarcinoma: The role of RELB

Feng, P. H., Yu, C. T., Chen, K. Y., Luo, C. S., Wu, S. M., Liu, C. Y., Kuo, L. W., Chan, Y. F., Chen, T. T., Chang, C. C., Lee, C. N., Chuang, H. C., Lin, C. F., Han, C. L., Lee, W. H. & Lee, K. Y., Jan 26 2018, In : Oncotarget. 9, 7, p. 7631-7643 13 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Macrophages
Microarray Analysis
Blood Cells
Alveolar Macrophages
6 Citations (Scopus)

Subcellular Proteome Landscape of Human Embryonic Stem Cells Revealed Missing Membrane Proteins

Weldemariam, M. M., Han, C-L., Shekari, F., Kitata, R. B., Chuang, C-Y., Hsu, W-T., Kuo, H-C., Choong, W-K., Sung, T-Y., He, F-C., Chung, M. C. M., Salekdeh, G. H. & Chen, Y-J., Dec 7 2018, In : Journal of Proteome Research. 17, 12, p. 4138-4151 14 p.

Research output: Contribution to journalArticle

Proteome
Stem cells
Membrane Proteins
Proteins
Peptides
3 Citations (Scopus)
Antrodia
Cell growth
Drug Resistance
lungs
Cell Movement
3 Citations (Scopus)

Suppressive activities and mechanisms of ugonin J on vascular smooth muscle cells and balloon angioplasty-induced neointimal hyperplasia

Pan, C. H., Li, P. C., Chien, Y. C., Yeh, W. T., Liaw, C. C., Sheu, M. J. & Wu, C. H., 2018, In : Phytotherapy Research.

Research output: Contribution to journalArticle

Balloon Angioplasty
Vascular Smooth Muscle
Smooth Muscle Myocytes
Hyperplasia
Cell Movement
4 Citations (Scopus)

Theissenolactone C exhibited ocular protection of endotoxin-induced uveitis by attenuating ocular inflammatory responses and glial activation

Lin, F. L., Ho, J. D., Cheng, Y. W., Chiou, G. C. Y., Yen, J. L., Chang, H. M., Lee, T. H. & Hsiao, G., Apr 9 2018, In : Frontiers in Pharmacology. 9, APR, 326.

Research output: Contribution to journalArticle

Uveitis
Endotoxins
Neuroglia
Microglia
Tumor Necrosis Factor-alpha
9 Citations (Scopus)
Glucosides
Doxorubicin
antioxidant
Antioxidants
Focal Segmental Glomerulosclerosis
9 Citations (Scopus)

β-Amyloid Induces Pathology-Related Patterns of Tau Hyperphosphorylation at Synaptic Terminals

Wu, H-Y., Kuo, P-C., Wang, Y-T., Lin, H-T., Roe, A. D., Wang, B. Y., Han, C-L., Hyman, B. T., Chen, Y-J. & Tai, H-C., Sep 1 2018, In : Journal of Neuropathology and Experimental Neurology. 77, 9, p. 814-826 13 p.

Research output: Contribution to journalArticle

Presynaptic Terminals
Amyloid
Phosphotransferases
Proline
Pathology
2017
23 Citations (Scopus)

Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and Akt activation in non-small cell lung cancer cells

Tsai, M. H., Liu, J. F., Chiang, Y. C., Hu, S. C. S., Hsu, L. F., Lin, Y. C., Lin, Z. C., Lee, H. C., Chen, M. C., Huang, C. L. & Lee, C. W., 2017, In : Oncotarget. 8, 17, p. 28342-28358 17 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Reactive Oxygen Species
Apoptosis
Noxae
Protein Kinases
5 Citations (Scopus)
Eriobotrya
fibroblasts
ultraviolet radiation
leaves
Fibroblasts
2 Citations (Scopus)
Anti-Allergic Agents
Regulatory T-Lymphocytes
Interleukin-10
Dendritic Cells
Asthma
Ovalbumin
Medicine
Inflammation
Microbiology
Allergy and Immunology
6 Citations (Scopus)
Autophagy
Colorectal Neoplasms
Cell Death
HCT116 Cells
Cyclin B1
8 Citations (Scopus)

Identification of Potential Plasma Biomarkers for Nonalcoholic Fatty Liver Disease by Integrating Transcriptomics and Proteomics in Laying Hens

Tsai, M. T., Chen, Y. J., Chen, C. Y., Tsai, M. H., Han, C. L., Chen, Y. J., Mersmann, H. J. & Ding, S. T., Mar 1 2017, In : The Journal of nutrition. 147, 3, p. 293-303 11 p.

Research output: Contribution to journalArticle

Proteomics
Biomarkers
Chickens
Liver
Dipeptidyl Peptidase 4
1 Citation (Scopus)

Intermedin A, a New Labdane Diterpene Isolated from Alpinia intermedia, Prolonged the Survival Time of P-388D1 Tumor-Bearing CDF1 Mice

Chen, L. G., Su, P. J., Tsai, P. W., Yang, L. L. & Wang, C. C., 2017, In : Planta Medica.

Research output: Contribution to journalArticle

Bearings (structural)
Alpinia
Diterpenes
Tumors
HL-60 Cells
4 Citations (Scopus)

Membrane proteomics of impaired energetics and cytoskeletal disorganization in elderly diet-induced diabetic mice

Hung, C. L., Pan, S. H., Han, C. L., Chang, C. W., Hsu, Y. L., Su, C. H., Shih, S. C., Lai, Y. J., Chiau, J. S. C., Yeh, H. I., Liu, C. Y., Lee, H. C. & Lam, C. S. P., Oct 6 2017, In : Journal of Proteome Research. 16, 10, p. 3504-3513 10 p.

Research output: Contribution to journalArticle

Diabetic Diet
Nutrition
Proteomics
Membranes
Cardiac Myocytes
2 Citations (Scopus)

Meroterpenoids from a Medicinal Fungus Antrodia cinnamomea

Chen, M. C., Cho, T. Y., Kuo, Y. H. & Lee, T. H., Sep 22 2017, In : Journal of Natural Products. 80, 9, p. 2439-2446 8 p.

Research output: Contribution to journalArticle

Antrodia
Fungi
antroquinonol
Alcoholic Intoxication
Structure-Activity Relationship
6 Citations (Scopus)

Monoamine oxidase A is highly expressed in classical Hodgkin lymphoma

Li, P. C., Siddiqi, I. N., Mottok, A., Loo, E. Y., Wu, C. H., Cozen, W., Steidl, C. & Shih, J. C., Oct 1 2017, In : Journal of Pathology. 243, 2, p. 220-229 10 p.

Research output: Contribution to journalArticle

Monoamine Oxidase
Hodgkin Disease
Lymphoma
Clorgyline
Non-Hodgkin's Lymphoma