Ph. D. Program in the Clinical Drug Development of Herbal Medicine

Research Output

2020

Acetylcholinesterase inhibitory activity and neuroprotection: In vitro, molecular docking, and improved learning and memory functions of demethylcurcumin in scopolamine-induced amnesia ICR mice

Liu, Y. H., Lee, C. J., Chen, L. C., Lee, T. L., Hsieh, Y. Y., Han, C. H., Yang, C. H., Huang, W. J. & Hou, W. C., Mar 2020, In : Food and Function. 11, 3, p. 2328-2338 11 p.

Research output: Contribution to journalArticle

Aza-PBHA, a potent histone deacetylase inhibitor, inhibits human gastric-cancer cell migration via PKCα-mediated AHR-HDAC interactions

Tsai, C. H., Li, C. H., Liao, P. L., Chang, Y. W., Cheng, Y. W. & Kang, J. J., Feb 2020, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1867, 2, 118564.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Bioassay-guided isolation and HPLC quantification of antiproliferative metabolites from Stahlianthus thorelii

Nguyen, N. L., Vo, T. H., Lin, Y. C., Liaw, C. C., Lin, Z. H., Chen, M. C. & Kuo, Y. H., Jan 28 2020, In : Molecules. 25, 3, 551.

Research output: Contribution to journalArticle

Open Access
Open Access
Open Access

In vitro and in vivo evaluation of the neuroprotective activity of Uncaria hirsuta Haviland

Lin, C. M., Lin, Y. T., Lee, T. L., Imtiyaz, Z., Hou, W. C. & Lee, M. H., Jan 2020, In : Journal of Food and Drug Analysis. 28, 1, p. 147-158 12 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression

Mehndiratta, S., Lin, M. H., Wu, Y. W., Chen, C. H., Wu, T. Y., Chuang, K. H., Chao, M. W., Chen, Y. Y., Pan, S. L., Chen, M. C. & Liou, J. P., Jan 1 2020, In : European Journal of Medicinal Chemistry. 185, p. 111725 111725.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Synthesis and biological evaluation of 2-quinolineacrylamides

Wang, S. W., Lin, M. H., Hsu, F. C., Chen, M. C., Liou, J. P., Liu, Y. T., Chen, S. S. & Lee, H. Y., Feb 1 2020, In : Bioorganic and Medicinal Chemistry. 28, 3, p. 115250 115250.

Research output: Contribution to journalArticle

Transcriptomic and Proteomic Profiling of Human Mesenchymal Stem Cell Derived from Umbilical Cord in the Study of Preterm Birth

Chien, C. W., Lo, Y. S., Wu, H. Y., Hsuan, Y., Lin, C. K., Chen, Y. J., Lin, W. & Han, C. L., Jan 2020, In : Proteomics - Clinical Applications. 14, 1, 1900024.

Research output: Contribution to journalArticle

2019

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase

Lai, M. J., Ojha, R., Lin, M. H., Liu, Y. M., Lee, H. Y., Lin, T. E., Hsu, K. C., Chang, C. Y., Chen, M. C., Nepali, K., Chang, J. Y. & Liou, J. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 612-630 19 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Alteration of mesenchymal stem cells polarity by laminar shear stimulation promoting β-catenin nuclear localization

Chen, W-T., Hsu, W-T., Yen, M-H., Changou, C. A., Han, C-L., Chen, Y-J., Cheng, J-Y., Chang, T-H., Lee, O. K-S. & Ho, J. H-C., Jan 1 2019, In : Biomaterials. 190-191, p. 1-10 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Correction: Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and Akt activation in non-small cell lung cancer cells

Tsai, M. H., Liu, J. F., Chiang, Y. C., Hu, S. C. S., Hsu, L. F., Lin, Y. C., Lin, Z. C., Lee, H. C., Chen, M. C., Huang, C. L. & Lee, C. W., May 21 2019, In : Oncotarget. 10, 36, p. 3430 1 p.

Research output: Contribution to journalArticle

Open Access

Down-regulation of aryl hydrocarbon receptor intensifies carcinogen-induced retinal lesion via SOCS3-STAT3 signaling

Tsai, C. H., Lee, Y., Li, C. H., Cheng, Y. W. & Kang, J. J., Jan 1 2019, (Accepted/In press) In : Cell Biology and Toxicology.

Research output: Contribution to journalArticle

Elucidation of the Effects of Si-Wu Tang on Menstrual Disorder Patterns through Activation of Aromatase and Antioxidation

Huang, G. C., Tsai, Y. Z., Lee, C. J., Chang, H. Y. & Wang, C. C., Mar 6 2019, In : Evidence-based Complementary and Alternative Medicine. 2019, p. 4761651 8 p., 4761651.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata

Chen, M. C., Wang, G. J., Kuo, Y. H., Chiang, Y. R., Cho, T. Y., Ju, Y. M. & Lee, T. H., Jan 1 2019, In : Journal of Food and Drug Analysis. 27, 1, p. 111-117 7 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Liposomal irinotecan for treatment of colorectal cancer in a preclinical model

Huang, J. R., Lee, M. H., Li, W. S. & Wu, H. C., Mar 1 2019, In : Cancers. 11, 3, 281.

Research output: Contribution to journalArticle

Open Access
Open Access
1 Citation (Scopus)
1 Citation (Scopus)

Stability of Principal Hydrolysable Tannins from Trapa taiwanensis Hulls

Wang, C. C., Chen, H. F., Wu, J. Y. & Chen, L. G., Jan 21 2019, In : Molecules. 24, 2, 365.

Research output: Contribution to journalArticle

Open Access

The fungus-derived retinoprotectant theissenolactone C improves glaucoma-like injury mediated by MMP-9 inhibition

Lin, F. L., Cheng, Y. W., Yu, M., Ho, J. D., Kuo, Y. C., Chiou, G. C. Y., Chang, H. M., Lee, T. H. & Hsiao, G., Mar 15 2019, In : Phytomedicine. 56, p. 207-214 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

4-O-Caffeoylquinic acid as an antioxidant marker for mulberry leaves rich in phenolic compounds

Ganzon, J. G., Chen, L. G. & Wang, C. C., 2018, In : Journal of Food and Drug Analysis.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Bradycardia and hypotension from improper use of aconite root: A case report and brief review

Chou, P. Y., Wang, C. C., Tai, C. J., Yang, T. L. & Tang, Y. J., Oct 1 2018, In : Complementary Medicine Research. 25, 5, p. 338-343 6 p.

Research output: Contribution to journalReview article

Chemotherapy Immunophenoprofiles in Non-Small-Cell Lung Cancer by Personalized Membrane Proteomics

Putri, D. U., Feng, P. H., Hsu, Y. H., Lee, K. Y., Jiang, F. W., Kuo, L. W., Chen, Y. J. & Han, C. L., Jan 1 2018, (Accepted/In press) In : Proteomics - Clinical Applications.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Design of diarylheptanoid derivatives as dual inhibitors against class IIa histone deacetylase and β-amyloid aggregation

Chen, L. C., Tseng, H. J., Liu, C. Y., Huang, Y. Y., Yen, C. C., Weng, J. R., Lu, Y. L., Hou, W. C., Lin, T. E., Pan, I. H., Huang, K. K., Huang, W. J. & Hsu, K. C., Jul 3 2018, In : Frontiers in Pharmacology. 9, JUL, 708.

Research output: Contribution to journalArticle

2 Citations (Scopus)
4 Citations (Scopus)

Discovery of aliphatic-chain hydroxamates containing indole derivatives with potent class I histone deacetylase inhibitory activities

Chao, S. W., Chen, L. C., Yu, C. C., Liu, C. Y., Lin, T. E., Guh, J. H., Wang, C. Y., Chen, C. Y., Hsu, K. C. & Huang, W. J., Jan 1 2018, In : European Journal of Medicinal Chemistry. 143, p. 792-805 14 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Dose-dependent pharmacokinetics and tentative identification of urine metabolites from an isosteviol derivative with anti-hepatitis B activity in rats

Kachingwe, B. H., Wang, L-H., Uang, Y-S., Huang, T-J. & Lin, S-J., Sep 1 2018, In : Biomedical Chromatography. 32, 9, p. e4266 e4266.

Research output: Contribution to journalArticle

Erratum: Author Correction: Poly-protein G-expressing bacteria enhance the sensitivity of immunoassays (Scientific reports (2017) 7 1 (989))

Hao, W. R., Chen, M., Chen, Y. J., Su, Y. C., Cheng, C. M., Hsueh, H. Y., Kao, A. P., Hsieh, Y. C., Chang, J., Tseng, M. Y. & Chuang, K. H., Mar 6 2018, In : Scientific Reports. 8, 1, 1 p.

Research output: Contribution to journalComment/debate

Open Access

Genomic Alterations of Extrectra Cellular Genes as Diagnosis Markers for Head and Neck Squamous Cell Carcinoma

Yang, C-H., Lin, R-D., Lee, M-H., Tsai, M-H. & Su, L-J., 2018, In : International Journal of Head and Neck Science. 2, 1, p. 21-24 4 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
3 Citations (Scopus)

Increased risk of a herpes zoster attack in patients receiving androgen deprivation therapy for prostate cancer

Wu, F. J., Kao, L. T., Sheu, S. Y., Lin, H. C. & Chung, S. D., Mar 1 2018, In : Andrologia. 50, 2, e12863.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Inhibitory effects of punicalagin from Punica granatum against type II collagenase-induced osteoarthritis

Lee, C. J., Chen, L. G., Liang, W. L., Hsieh, M. S. & Wang, C. C., Feb 1 2018, In : Journal of Functional Foods. 41, p. 216-222 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

In vitro and in vivo anti-osteoarthritis effects of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside from Polygonum multiflorum

Tsai, P. W., Lee, Y. H., Chen, L. G., Lee, C. J. & Wang, C. C., Jan 1 2018, In : Molecules. 23, 3, 571.

Research output: Contribution to journalArticle

4 Citations (Scopus)

ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells

Chang, C. W., Chen, Y. S., Tsay, Y. G., Han, C. L., Chen, Y. J., Yang, C. C., Hung, K. F., Lin, C. H., Huang, T. Y., Kao, S. Y., Lee, T. C. & Lo, J. F., Feb 1 2018, In : Cell Death and Disease. 9, 2, 194.

Research output: Contribution to journalArticle

12 Citations (Scopus)

S100A9+ MDSC and TAM-mediated EGFR-TKI resistance in lung adenocarcinoma: The role of RELB

Feng, P. H., Yu, C. T., Chen, K. Y., Luo, C. S., Wu, S. M., Liu, C. Y., Kuo, L. W., Chan, Y. F., Chen, T. T., Chang, C. C., Lee, C. N., Chuang, H. C., Lin, C. F., Han, C. L., Lee, W. H. & Lee, K. Y., Jan 26 2018, In : Oncotarget. 9, 7, p. 7631-7643 13 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Subcellular Proteome Landscape of Human Embryonic Stem Cells Revealed Missing Membrane Proteins

Weldemariam, M. M., Han, C-L., Shekari, F., Kitata, R. B., Chuang, C-Y., Hsu, W-T., Kuo, H-C., Choong, W-K., Sung, T-Y., He, F-C., Chung, M. C. M., Salekdeh, G. H. & Chen, Y-J., Dec 7 2018, In : Journal of Proteome Research. 17, 12, p. 4138-4151 14 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
5 Citations (Scopus)

Suppressive activities and mechanisms of ugonin J on vascular smooth muscle cells and balloon angioplasty-induced neointimal hyperplasia

Pan, C. H., Li, P. C., Chien, Y. C., Yeh, W. T., Liaw, C. C., Sheu, M. J. & Wu, C. H., 2018, In : Phytotherapy Research.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Theissenolactone C exhibited ocular protection of endotoxin-induced uveitis by attenuating ocular inflammatory responses and glial activation

Lin, F. L., Ho, J. D., Cheng, Y. W., Chiou, G. C. Y., Yen, J. L., Chang, H. M., Lee, T. H. & Hsiao, G., Apr 9 2018, In : Frontiers in Pharmacology. 9, APR, 326.

Research output: Contribution to journalArticle

6 Citations (Scopus)
10 Citations (Scopus)

β-Amyloid Induces Pathology-Related Patterns of Tau Hyperphosphorylation at Synaptic Terminals

Wu, H-Y., Kuo, P-C., Wang, Y-T., Lin, H-T., Roe, A. D., Wang, B. Y., Han, C-L., Hyman, B. T., Chen, Y-J. & Tai, H-C., Sep 1 2018, In : Journal of Neuropathology and Experimental Neurology. 77, 9, p. 814-826 13 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2017

Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and Akt activation in non-small cell lung cancer cells

Tsai, M. H., Liu, J. F., Chiang, Y. C., Hu, S. C. S., Hsu, L. F., Lin, Y. C., Lin, Z. C., Lee, H. C., Chen, M. C., Huang, C. L. & Lee, C. W., 2017, In : Oncotarget. 8, 17, p. 28342-28358 17 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
5 Citations (Scopus)
2 Citations (Scopus)
7 Citations (Scopus)

Identification of Potential Plasma Biomarkers for Nonalcoholic Fatty Liver Disease by Integrating Transcriptomics and Proteomics in Laying Hens

Tsai, M. T., Chen, Y. J., Chen, C. Y., Tsai, M. H., Han, C. L., Chen, Y. J., Mersmann, H. J. & Ding, S. T., Mar 1 2017, In : The Journal of nutrition. 147, 3, p. 293-303 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)