Master Program in Graduate Institute of Cancer Biology and Drug Discovery

Research Output 2013 2019

2019
2 Citations (Scopus)

Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivo

Hsieh, Y. L., Tu, H. J., Pan, S. L., Liou, J. P. & Yang, C. R., Jun 1 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 6, p. 992-1003 12 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Histone Deacetylase Inhibitors
Breast Neoplasms
Histone Deacetylases
Acetylation

Arecoline-regulated ataxia telangiectasia mutated expression level in oral cancer progression

Tu, H. F., Chen, M. Y., Lai, J. C. Y., Chen, Y. L., Wong, Y. W., Yang, C. C., Chen, H. Y., Hsia, S. M., Shih, Y. H. & Shieh, T. M., Jan 1 2019, In : Head and Neck.

Research output: Contribution to journalArticle

Arecoline
Ataxia Telangiectasia
Mouth Neoplasms
Squamous Cell Carcinoma
DNA Repair

Dental Pulp Stem Cell Transplantation with 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside Accelerates Alveolar Bone Regeneration in Rats

Lin, C. Y., Kuo, P. J., Chin, Y. T., Weng, I. T., Lee, H. W., Huang, H. M., Lin, H. Y., Hsiung, C. N., Chan, Y. H. & Lee, S. Y., Apr 1 2019, In : Journal of Endodontics. 45, 4, p. 435-441 7 p.

Research output: Contribution to journalArticle

Dental Pulp
Bone Regeneration
Stem Cell Transplantation
Stem Cells
Osteogenesis
Embryonal Carcinoma Stem Cells
Neural Stem Cells
Zinc Fingers
Transcription
Zinc
Open Access
Cell Cycle Proteins
Epithelial-Mesenchymal Transition
regulators
Prostatic Neoplasms
genes

Identification of two independent SUMO-interacting motifs in Fas-associated factor 1 (FAF1): Implications for mineralocorticoid receptor (MR)-mediated transcriptional regulation

Wang, C. H., Hung, P. W., Chiang, C. W., Lombès, M., Chen, C. H., Lee, K. H., Lo, Y. C., Wu, M. H., Chang, W. C. & Lin, D. Y., Aug 1 2019, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 8, p. 1282-1297 16 p.

Research output: Contribution to journalArticle

Mineralocorticoid Receptors
Ubiquitin
Catenins
Aldosterone
Transcriptional Activation

Leptin-derived peptides block leptin-induced proliferation by reducing expression of pro-inflammatory genes in hepatocellular carcinoma cells

Ho, Y., Wang, S. H., Chen, Y. R., Li, Z. L., Chin, Y. T., Yang, Y. C. S. H., Wu, Y. H., Su, K. W., Chu, H. R., Chiu, H. C., Crawford, D. R., Shih, Y. J., Grasso, P., Tang, H. Y., Lin, H. Y., Davis, P. J., Whang-Peng, J. & Wang, K., Nov 1 2019, In : Food and Chemical Toxicology. 133, 110808.

Research output: Contribution to journalArticle

leptin (116-130)
hepatoma
Leptin
leptin
Hepatocellular Carcinoma
1 Citation (Scopus)

Leukemia Inhibitory Factor Promotes Castration-resistant Prostate Cancer and Neuroendocrine Differentiation by Activated ZBTB46

Liu, Y-N., Niu, S., Chen, W-Y., Zhang, Q., Tao, Y., Chen, W-H., Jiang, K-C., Chen, X., Shi, H., Liu, A., Li, J., Li, Y., Lee, Y-C., Zhang, X. & Huang, J., Apr 8 2019, In : Clinical cancer research : an official journal of the American Association for Cancer Research.

Research output: Contribution to journalArticle

Leukemia Inhibitory Factor
Castration
Prostatic Neoplasms
Androgens
Therapeutics
2 Citations (Scopus)

Natural Antioxidant Resveratrol Suppresses Uterine Fibroid Cell Growth and Extracellular Matrix Formation In Vitro and In Vivo

Chen, H-Y., Lin, P-H., Shih, Y-H., Wang, K-L., Hong, Y-H., Shieh, T-M., Huang, T-C. & Hsia, S-M., Apr 12 2019, In : Antioxidants. 8, 4

Research output: Contribution to journalArticle

Leiomyoma
Cell growth
Extracellular Matrix
Antioxidants
Growth
1 Citation (Scopus)

New paradigm of functional regulation by DNA mimic proteins: Recent updates

Wang, H. C., Chou, C. C., Hsu, K. C., Lee, C. H. & Wang, A. H. J., May 1 2019, In : IUBMB Life. 71, 5, p. 539-548 10 p.

Research output: Contribution to journalReview article

DNA
Charge distribution
Proteins
Clustered Regularly Interspaced Short Palindromic Repeats
Uracil-DNA Glycosidase
12 Citations (Scopus)

Novel Common Genetic Susceptibility Loci for Colorectal Cancer

Schmit, S. L., Edlund, C. K., Schumacher, F. R., Gong, J., Harrison, T. A., Huyghe, J. R., Qu, C., Melas, M., Van Den Berg, D. J., Wang, H., Tring, S., Plummer, S. J., Albanes, D., Alonso, M. H., Amos, C. I., Anton, K., Aragaki, A. K., Arndt, V., Barry, E. L., Berndt, S. I. & 30 others, Bezieau, S., Bien, S., Bloomer, A., Boehm, J., Boutron-Ruault, M. C., Brenner, H., Brezina, S., Buchanan, D. D., Butterbach, K., Caan, B. J., Campbell, P. T., Carlson, C. S., Castelao, J. E., Chan, A. T., Chang-Claude, J., Chanock, S. J., Cheng, I., Cheng, Y. W., Chin, L. S., Church, J. M., Church, T., Coetzee, G. A., Cotterchio, M., Cruz Correa, M., Curtis, K. R., Duggan, D., Lin, Y., Liu, Y. R., Yen, Y. & Hsu, L., Feb 1 2019, In : Journal of the National Cancer Institute. 111, 2, p. 146-157 12 p.

Research output: Contribution to journalArticle

Genetic Loci
Genetic Predisposition to Disease
Colorectal Neoplasms
Genome-Wide Association Study
Confidence Intervals

RAB14 activates MARK signaling to promote bladder tumorigenesis

Chao, H., Deng, L., Xu, F., Fu, B., Zhu, Z., Dong, Z., Liu, Y-N. & Zeng, T., Feb 27 2019, In : Carcinogenesis.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Carcinogenesis
Urinary Bladder
Mitogen-Activated Protein Kinases
Twist-Related Protein 1

Resveratrol antagonizes thyroid hormone-induced expression of checkpoint and proliferative genes in oral cancer cells

Lin, C. C., Chin, Y. T., Shih, Y. J., Chen, Y. R., Chung, Y. Y., Lin, C. Y., Hsiung, C. N., Whang-Peng, J., Lee, S. Y., Lin, H. Y., Davis, P. J. & Wang, K., Jan 1 2019, In : Journal of Dental Sciences.

Research output: Contribution to journalArticle

Open Access
Mouth Neoplasms
Thyroxine
Thyroid Hormones
Genes
Cell Cycle Checkpoints

Tetrac and NDAT Induce Anti-proliferation via Integrin αvβ3 in Colorectal Cancers With Different K-RAS Status

Chin, Y-T., He, Z-R., Chen, C-L., Chu, H-C., Ho, Y., Su, P-Y., Yang, Y-C. S. H., Wang, K., Shih, Y-J., Chen, Y-R., Pedersen, J. Z., Incerpi, S., Nana, A. W., Tang, H-Y., Lin, H-Y., Mousa, S. A., Davis, P. J. & Whang-Peng, J., 2019, In : Frontiers in Endocrinology. 10, p. 130

Research output: Contribution to journalArticle

Integrins
Colorectal Neoplasms
HCT116 Cells
Neoplasms
HT29 Cells

The Ambivalent Role of lncRNA Xist in Carcinogenesis

Chen, Y. K. & Yen, Y., Apr 15 2019, In : Stem Cell Reviews and Reports. 15, 2, p. 314-323 10 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
X Chromosome Inactivation
Carcinogenesis
Neoplasms
X Chromosome

The expression profile and prognostic significance of metallothionein genes in colorectal cancer

Hung, K. C., Huang, T. C., Cheng, C. H., Cheng, Y. W., Lin, D. Y., Fan, J. J. & Lee, K. H., Aug 2 2019, In : International Journal of Molecular Sciences. 20, 16, 3849.

Research output: Contribution to journalArticle

Open Access
Metallothionein
genes
Colorectal Neoplasms
Genes
cancer
1 Citation (Scopus)

The synthetic retinoid ST1926 attenuates prostate cancer growth and potentially targets prostate cancer stem-like cells

Bahmad, H. F., Samman, H., Monzer, A., Hadadeh, O., Cheaito, K., Abdel-Samad, R., Hayar, B., Pisano, C., Msheik, H., Liu, Y-N., Darwiche, N. & Abou-Kheir, W., Jul 2019, In : Molecular Carcinogenesis. 58, 7, p. 1208-1220 13 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Retinoids
Prostatic Neoplasms
Growth
Apoptosis
2018

A homozygous variant in RRM2B is associated with severe metabolic acidosis and early neonatal death

Penque, B. A., Su, L., Wang, J., Ji, W., Bale, A., Luh, F., Fulbright, R. K., Sarmast, U., Sega, A. G., Konstantino, M., Spencer-Manzon, M., Pierce, R., Yen, Y. & Lakhani, S. A., Jan 1 2018, (Accepted/In press) In : European Journal of Medical Genetics.

Research output: Contribution to journalArticle

Acidosis
Mutation
Ribonucleotide Reductases
Failure to Thrive
Lactic Acidosis

A Novel Selective JAK2 Inhibitor Identified Using Pharmacological Interactions

Lin, T. E., HuangFu, W-C., Chao, M-W., Sung, T-Y., Chang, C-D., Chen, Y-Y., Hsieh, J-H., Tu, H-J., Huang, H-L., Pan, S-L. & Hsu, K-C., 2018, In : Frontiers in Pharmacology. 9, p. 1379

Research output: Contribution to journalArticle

Janus Kinases
Phosphotransferases
Binding Sites
Pharmacology
Cytokine Receptors
3 Citations (Scopus)

Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction

Cheng, C. T., Qi, Y., Wang, Y. C., Chi, K. K., Chung, Y., Ouyang, C., Chen, Y. R., Oh, M. E., Sheng, X., Tang, Y., Liu, Y. R., Lin, H. H., Kuo, C. Y., Schones, D., Vidal, C. M., Chu, J. C. Y., Wang, H. J., Chen, Y. H., Miller, K. M., Chu, P. & 4 others, Yen, Y., Jiang, L., Kung, H. J. & Ann, D. K., Dec 1 2018, In : Communications Biology. 1, 1, 178.

Research output: Contribution to journalArticle

Open Access
aspartic acid
Starvation
Aspartic Acid
arginine
starvation

Bioactivity of Thyroid Hormone Analogs at Cancer Cells

Davis, P. J., Tang, H-Y., Hercbergs, A., Lin, H-Y., Keating, K. A. & Mousa, S. A., 2018, In : Frontiers in Endocrinology. 9, p. 739

Research output: Contribution to journalReview article

Thyroid Hormones
Thyronines
Thyroid Hormone Receptors
Integrins
Neoplasms

Correction: Loss of EGFR signaling-regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance [Oncotarget. 5, (2014), 3770-3784]doi 10.18632/oncotarget.1994

Siu, M. K., Abou-Kheir, W., Yin, J. J., Chang, Y. S., Barrett, B., Suau, F., Casey, O., Chen, W. Y., Fang, L., Hynes, P., Hsieh, Y. Y., Liu, Y. N., Huang, J. & Kelly, K., Aug 17 2018, In : Oncotarget. 9, 64, p. 32403 1 p.

Research output: Contribution to journalComment/debate

Bone Neoplasms
Protein-Tyrosine Kinases
Prostatic Neoplasms
Medicine
Neoplasm Metastasis

Distributed and side-pumped fiber laser using a laser diode bar stack

Lee, Y. W., Huangfu, W. C., Li, Y. Y., Wu, I. C., Huang, S. L., Peter Liaw, S. K. & Dubinskii, M., Jan 1 2018, In : IEEE Access. 6, p. 70456-70462 7 p., 8533341.

Research output: Contribution to journalArticle

Fiber lasers
Semiconductor lasers
Pumps
Fibers
Fused silica
1 Citation (Scopus)

Heteronemin induces anti-Proliferation in cholangiocarcinoma cells via inhibiting TGF-β pathway

Lin, H. Y., Tey, S. L., Ho, Y., Chin, Y. T., Wang, K., Whang-Peng, J., Shih, Y. J., Chen, Y. R., Yang, Y. N., Chen, Y. C., Liu, Y. C., Tang, H. Y. & Yang, Y. C. SH., Dec 6 2018, In : Marine Drugs. 16, 12, 489.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Transforming Growth Factors
Neoplasm Metastasis
Cell Adhesion
Cell Movement
5 Citations (Scopus)

Influences of core morphology on electrocapacitive performance of NiCo2O4-based core/shell electrodes

Lin, L-Y., Lin, H-Y., Hong, W-L. & Lin, L-Y., 2018, In : Thin Solid Films. 667, p. 69-75 7 p.

Research output: Contribution to journalArticle

Nanowires
Nanosheets
Nickel
Energy storage
Electrodes
5 Citations (Scopus)

Protective Effect of Melatonin against Oxidative Stress-Induced Apoptosis and Enhanced Autophagy in Human Retinal Pigment Epithelium Cells

Chang, C. C., Huang, T. Y., Chen, H. Y., Huang, T. C., Lin, L. C., Chang, Y. J. & Hsia, S. M., Jan 1 2018, In : Oxidative Medicine and Cellular Longevity. 2018, 9015765.

Research output: Contribution to journalArticle

Oxidative stress
Retinal Pigments
Retinal Pigment Epithelium
Autophagy
Melatonin
2 Citations (Scopus)

Radioresistance of cancer cells, integrin αvβ3 and thyroid hormone

Leith, J. T., Mousa, S. A., Hercbergs, A., Lin, H. Y. & Davis, P. J., Dec 1 2018, In : Oncotarget. 9, 97, p. 37069-37075 7 p.

Research output: Contribution to journalReview article

Thyroid Hormones
Integrins
Neoplasms
Thyroid Hormone Receptors
Radiation Tolerance

Ribonucleotide reductase subunit M2B deficiency leads to mitochondrial permeability transition pore opening and is associated with aggressive clinicopathologic manifestations of breast cancer

Xue, L., Liu, X., Wang, Q., Liu, C. Q., Chen, Y., Jia, W., Hsie, R., Chen, Y., Luh, F., Zheng, S. & Yen, Y., Jan 1 2018, In : American Journal of Translational Research. 10, 11, p. 3635-3649 15 p., AJTR0084684.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Breast Neoplasms
KB Cells
Spermine
MCF-7 Cells
4 Citations (Scopus)

Roles of Fc domain and exudation in L2 antibody-mediated protection against human papillomavirus

Wang, J. W., Wu, W. H., Huang, T. C., Wong, M., Kwak, K., Ozato, K., Hung, C. F. & Roden, R. B. S., Aug 1 2018, In : Journal of Virology. 92, 15, e00572-18.

Research output: Contribution to journalArticle

Papillomaviridae
exudation
Immunoglobulin G
neutralization
antibodies

Roles of Resveratrol as Signaling Sensor and Gatekeeper

Shih, Y-J., Chen, Y. R., Wang, K., Whang-Peng, J., Tang, H. Y., Lin, H-Y. & Davis, P. J., 2018, Resveratrol: State-of-the-Art Science and Health Applications. World Scientific Publishing Co., p. 115-144

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Diptera
Neurodegenerative Diseases
resveratrol
Coronary Artery Disease
Fruit
2 Citations (Scopus)

Tetraiodothyroacetic acid (tetrac), integrin αvβ3 and disabling of immune checkpoint defense

Davis, P. J., Mousa, S. A. & Lin, H. Y., Jan 1 2018, In : Future Medicinal Chemistry. 10, 14, p. 1637-1639 3 p.

Research output: Contribution to journalEditorial

Integrins
tetraiodothyroacetic acid

The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells

Tu, H. J., Lin, Y. J., Chao, M. W., Sung, T. Y., Wu, Y. W., Chen, Y. Y., Lin, M. H., Liou, J. P., Pan, S. L. & Yang, C. R., Dec 29 2018, In : Clinical Epigenetics. 10, 1, 162.

Research output: Contribution to journalArticle

Leukemia
Vincristine
Doxorubicin
Drug Therapy
Neoplasms
2017
7 Citations (Scopus)

Mechanisms of action of nonpeptide hormones on resveratrol-induced antiproliferation of cancer cells

Lin, H. Y., Hsieh, M. T., Cheng, G. Y., Lai, H. Y., Chin, Y. T., Shih, Y. J., Nana, A. W., Lin, S. Y., Yang, Y. C. S. H., Tang, H. Y., Chiang, I. J. & Wang, K., 2017, (Accepted/In press) In : Annals of the New York Academy of Sciences. p. 92-100

Research output: Contribution to journalReview article

Cells
Hormones
Neoplasms
Integrins
Phosphotransferases
2016
6 Citations (Scopus)

Effects of Dang-Gui-Bu-Xue-Tang, an herbal decoction, on iron uptake in iron-deficient anemia

Huang, G. C., Chen, S. Y., Tsai, P. W., Ganzon, J. G., Lee, C. J., Shiah, H. S. & Wang, C. C., Mar 2 2016, In : Drug Design, Development and Therapy. 10, p. 949-957 9 p.

Research output: Contribution to journalArticle

ferrous sulfate
Anemia
Iron
Hemoglobins
Caco-2 Cells
10 Citations (Scopus)

Integrin β3 and LKB1 are independently involved in the inhibition of proliferation by lovastatin in human intrahepatic cholangiocarcinoma

Yang, S. H., Lin, H. Y., Changou, C. A., Chen, C. H., Liu, Y. R., Wang, J., Jiang, X., Luh, F. & Yen, Y., Jan 1 2016, In : Oncotarget. 7, 1, p. 362-373 12 p.

Research output: Contribution to journalArticle

Lovastatin
Cholangiocarcinoma
Integrins
Cell Adhesion
Intercellular Adhesion Molecule-1
2014
20 Citations (Scopus)

Dovitinib synergizes with oxaliplatin in suppressing cell proliferation and inducing apoptosis in colorectal cancer cells regardless of RAS-RAF mutation status

Gaur, S., Chen, L., Ann, V., Lin, W. C., Wang, Y., Chang, V. H. S., Hsu, N. Y., Shia, H. S. & Yen, Y., Feb 4 2014, In : Molecular Cancer. 13, 1, 21.

Research output: Contribution to journalArticle

oxaliplatin
Colorectal Neoplasms
Cell Proliferation
Heterografts
Colonic Neoplasms

Jejunal Cancer with WRN Mutation Identified from Next-Generation Sequencing: A Case Study and Minireview

Chang, C., Shiah, H-S., Hsu, N-Y., Huang, H. Y., Chu, J-S. & Yen, Y., 2014, In : Case Reports in Surgery.

Research output: Contribution to journalArticle

Jejunal Neoplasms
Jejunum
Mutation
Small Intestine
Exome
2013

Flow Cytometric Detection of Mitochondrial Membrane Potential

Chang, H-Y., Huang, H-C., Huang, T-C., Yang, P-C., Wang, Y-C. & Juan, H-F., Jan 1 2013

Research output: Book/ReportBook

Flow Cytometric Detection of Reactive Oxygen Species

Chang, H-Y., Huang, H-C., Huang, T-C., Yang, P-C., Wang, Y-C. & Juan, H-F., Jan 1 2013

Research output: Book/ReportBook