Master Program in Clinical Genomics and Proteomics

Projects

Projects per year 2012 2014 2015 2016 2017 2018 2019 2020 2022

• 3 Active
• 59 Finished

Projects per year

Search results

• b - Ministry of Science and Technology

  Discovery of Agents Disturbing Genome Stability during Chromatin Replication

  Lee, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 結合深度學習及數據非依賴採集質譜法以偵測膜蛋白體突變與癌症新生抗原(1/3)

  Han, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 選擇性抗癌標靶藥物HDAC6抑制劑臨床前試驗研究

  Pan, S.

  12/1/17 → 10/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Drug Discovery and Pharmacological Investigation of Selective Hdac1 and 2 Inhibitors as Novel Anticancer Drugs

  Pan, S.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histone 100%
  • Antitumor 34%
  • Antineoplastic Agent 33%
  • Drug 29%
  • DNA Sequence 19%

• Development of Mass Spectrometry-Based Quantification Strategies for Onco-Proteogenomics Investigation of Cancer-Specific Mutated Proteins (2nd~3rd Year)

  Han, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mutation 100%
  • Proteogenomics 74%
  • Mass Spectrometry 70%
  • Proteins 49%
  • Peptides 35%

• Mechanisms Study of Fatty Liver Diseases: Investigations on Potential Druggable Targets

  Hu, O. Y.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Drug Discovery and Pharmacological Study of Novel pan-HDAC Inhibitors as Anti-Angiogenic Drugs

  Pan, S.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histone Deacetylase Inhibitors 100%
  • Histone Deacetylases 36%
  • Drug Discovery 23%
  • 3-(1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)-N-hydroxyacrylamide 18%
  • Animal Models 16%

• Drug Discovery and Pharmacological Investigation of Novel Selective Hdac Inhibitors as Anticancer Drugs

  Pan, S.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of the Oncogenic Role of Prohibitin in Breast Cancer Progression

  Huang, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Oncogenic 100%
  • Rocaglamide 67%
  • Subcellular Localization 48%
  • Cell Viability 35%
  • Plasma 21%

• Tlk Function and Regulation in Chromatin Replication

  Lee, S.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Chromatin 100%
  • Genome 27%
  • Maintenance 21%
  • DNA Replication 20%
  • Histone Chaperones 15%

• Tlk Function and Regulation in Chromatin Replication (2nd Years)

  Lee, S.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Phosphotransferases 100%
  • Chromatin 66%
  • Genome 13%
  • DNA synthesome 12%
  • Proteomics 12%

• Development of Proteogenomics Platform for Multiplexed Screening of Membrane Protein Mutations

  Han, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 探討大葉樹蘭萃取物Rocaglamide A 對三陰性乳癌的影響及其作用機制

  Huang, T.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 新穎性pan-HDAC 抑制劑抑制血管新生之藥物研發與藥理作用機轉(3/3)

  Pan, S.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histone Deacetylase Inhibitors 100%
  • Histone Deacetylases 49%
  • 3-(1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)-N-hydroxyacrylamide 20%
  • Animal Models 18%
  • Drug Discovery 17%

• The Molecular Basis of Senp2 in Regulating Smad4 Sumoylation and Its Functions in Triple Negative Breast Cancer

  Chang, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

  • SUMO-1 Protein 100%
  • Transforming Growth Factor beta 99%
  • Peptide Hydrolases 83%
  • Sumoylation 26%
  • Triple Negative Breast Neoplasms 23%

• 開發混合型機器學習之代謝物滯留時間預測模型用於辨識液相層析串聯質譜儀實驗之代謝物(2/2)

  Wang, S.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Molecular Basis of Senp2 in Regulating Smad4 Sumoylation and Its Functions in Triple Negative Breast Cancer(2/3)

  Chang, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • SUMO-1 Protein 100%
  • Transforming Growth Factor beta 99%
  • Peptide Hydrolases 83%
  • Sumoylation 26%
  • Triple Negative Breast Neoplasms 23%

• 探討小泛素蛋白Sentrin-specific protease 2 參與轉型生長因子-beta訊息傳遞的作用機制(2/2)

  Chang, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Creating the SUMOylated-factor specific antibody and the application in biochemical analysis

  Chang, C.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 選擇性抗癌標靶藥物HDAC6抑制劑臨床前試驗研究(II)

  Pan, S.

  5/1/19 → 1/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 開發混合型機器學習之代謝物滯留時間預測模型用於辨識液相層析串聯質譜儀實驗之代謝物(1/2)

  Wang, S.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Drug Discovery and Pharmacological Investigation of Novel Selective Hdac Inhibitors as Anticancer Drugs(1/3)

  Pan, S.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Drug Discovery and Pharmacological Study of Novel pan-HDAC Inhibitors as Anti-Angiogenic Drugs

  Pan, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Histone Deacetylase Inhibitors 100%
  • Histone Deacetylases 36%
  • Drug Discovery 23%
  • 3-(1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)-N-hydroxyacrylamide 18%
  • Animal Models 16%

• Identification of Rewired Apc Mutation Signaling Network in Chemotherapy Resistant Response in Colorectal Cancer( III )

  Huang, T.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Elucidation of the Molecular Mechnism of Aglaia Elliptifolia Extract Rocaglamide Induced Cell Death in Breast Cancer Cells---PHB as a Target

  Huang, T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Rocaglamide 100%
  • Oncogenic 11%
  • Cell Death 8%

• The Investigation of the Regulatory Mechanism and Roles of Sentrin-Specific Protease 2 in Epithelial-Mesenchymal Transition and Breast Cancer Stemness

  Chang, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Mass Spectrometry-Based Quantification Strategies for Onco-Proteogenomics Investigation of Cancer-Specific Mutated Proteins (2nd~3rd Year)

  Han, C.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mutation 100%
  • Proteogenomics 74%
  • Mass Spectrometry 70%
  • Proteins 49%
  • Peptides 35%

• 建立可偵測多重膜蛋白突變之蛋白基因體平台（延續計畫）

  Han, C.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Regulation of Pml Degradation by Sentrin-Specific Protease 2

  Chang, C.

  11/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

  • SUMO-1 Protein 100%
  • Ubiquitination 96%
  • Sumoylation 79%
  • Peptide Hydrolases 74%
  • Protein Stability 70%

• Investigation of Hmga2-Microrna Regulatory Network to Tune Oncogenesis

  Huang, T.

  8/1/18 → 7/31/19

  Project: A - Government Institution › b - Ministry of Science and Technology

  • AT-Hook Motifs 100%
  • MicroRNAs 16%
  • Colorectal Neoplasms 12%
  • Carcinogenesis 9%
  • Neoplasms 7%

• 探討小泛素蛋白酶Sentrin-specific protease 2 參與轉型生長因子-beta訊息傳遞的作用機制(1/2)

  Chang, C.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立質譜定量分析策略以應用於癌症特定突變蛋白質之腫瘤蛋白質基因體學研究

  Han, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Mutation 100%
  • Mass Spectrometry 86%
  • Proteogenomics 68%
  • Peptides 43%
  • Neoplasms 35%

• The Molecular Basis of SENP2 in Regulating Smad4 Sumoylation and Its Functions in Triple Negative Breast Cancer

  Chang, C.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

  • SUMO-1 Protein 100%
  • Transforming Growth Factor beta 85%
  • Peptide Hydrolases 78%
  • Sumoylation 22%
  • Triple Negative Breast Neoplasms 20%

• Identification of Rewired APC Mutation Signaling Network in Chemotherapy Resistant Response in Colorectal Cancer (I)

  Huang, T.

  8/1/14 → 10/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

  • Adenomatous Polyposis Coli 100%
  • Colorectal Neoplasms 44%
  • Mutation 34%
  • Drug Resistance 28%
  • Fluorouracil 17%

• Identification of Rewired APC Mutation Signaling Network in Chemotherapy Resistant Response in Colorectal Cancer (II)

  Huang, T.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology
• c - Ministry of Health and Welfare

  Preclinical evaluation of novel selective HDAC6 inhibitors for human cancers treatment

  Pan, S.

  1/1/16 → 12/31/16

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • Mesylates 100%
  • ricolinostat 43%
  • Heterografts 39%
  • Investigational New Drug Application 37%
  • Outsourced Services 35%

• Preclinical evaluation of novel selective HDAC6 inhibitors for human cancers treatment

  Pan, S.

  1/1/15 → 12/31/15

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • ricolinostat 100%
  • Neoplasms 97%
  • Heterografts 90%
  • Investigational New Drug Application 86%
  • Pharmaceutical Preparations 62%

• Preclinical evaluation of novel selective HDAC6 inhibitors for human cancers treatment

  Pan, S.

  1/1/14 → 12/31/14

  Project: A - Government Institution › c - Ministry of Health and Welfare

  • ricolinostat 100%
  • Neoplasms 97%
  • Heterografts 90%
  • Investigational New Drug Application 86%
  • Pharmaceutical Preparations 62%
• d - Ministry of Education

  2-1-3 精進核心研究服務平台-陳宜民

  Chen, Y.

  1/1/20 → 12/31/20

  Project: A - Government Institution › d - Ministry of Education

• PM2.5對慢性阻塞性肺病在肺修復和再生受損的影響-空氣汙染引發慢性阻塞性肺病之個人化週邊免疫表徵圖譜及血液蛋白體分析

  Han, C.

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• 以體內及體外試驗來進行SYRK1B抑制劑之毒理學評估

  Pan, S.

  1/1/20 → 12/31/20

  Project: A - Government Institution › d - Ministry of Education

• 粒線體動態性改變重塑代謝路徑對抗藥性的影響

  Huang, T.

  1/1/20 → 12/31/20

  Project: A - Government Institution › d - Ministry of Education

• 長鏈非編碼核糖核酸LncHIFCAR/MIR31HG調控的中心網絡在胰臟癌的轉譯研究-解析長鏈非編碼核糖核酸MIR31HG之生物交互作用網路：跨體學分析

  Huang, T.

  1/1/19 → 12/1/19

  Project: A - Government Institution › d - Ministry of Education

• g - Research Grants for Newly Hired Faculty

  新聘教師研究補助

  Wang, S.

  5/1/18 → 4/30/20

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• 新聘教師研究補助

  Chen, Y.

  10/1/20 → 9/30/21

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• TMU103-AE1-B14

  Han, C.

  1/1/15 → 12/31/16

  Project: B - Project of TMU › g - Research Grants for Newly Hired Faculty

• h - Higher Education Sprout Project

  探討慢性阻塞性肺病之個人化周邊免疫表徵圖譜與其致病機制以分群暴露於懸浮微粒之阻塞性肺病臨床表現型

  Han, C.

  1/1/21 → 12/31/21

  Project: B - Project of TMU › h - Higher Education Sprout Project

• 探討慢性阻塞性肺病之個人化周邊免疫表徵圖譜與其致病機制以分群暴露於懸浮微粒之阻塞性肺病臨床表現型

  Han, C.

  1/1/21 → 12/31/21

  Project: B - Project of TMU › h - Higher Education Sprout Project

• 以定量蛋白體分析探討暴露PM2.5對慢性阻塞性肺病之肺氣腫致病機轉

  Han, C.

  1/1/22 → 12/31/22

  Project: B - Project of TMU › h - Higher Education Sprout Project

• i - Other (Funded by TMU)

  Targeting replication stress in cancer therapy (I)

  Lee, S.

  7/1/19 → 6/30/20

  Project: B - Project of TMU › i - Other (Funded by TMU)