Master Program for Clinical Pharmacogenomics and Pharmacoproteomics

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output 2008 2020

2020

Intercalating pyrene with polypeptide as a novel self-assembly nano-carrier for colon cancer suppression in vitro and in vivo

Lo, P. Y., Lee, G. Y., Zheng, J. H., Huang, J. H., Cho, E. C. & Lee, K. C., Apr 1 2020, In : Materials Science and Engineering C. 109, 110593.

Research output: Contribution to journalArticle

Polypeptides
Pyrene
polypeptides
pyrenes
Self assembly
2019
1 Citation (Scopus)

Alteration of mesenchymal stem cells polarity by laminar shear stimulation promoting β-catenin nuclear localization

Chen, W-T., Hsu, W-T., Yen, M-H., Changou, C. A., Han, C-L., Chen, Y-J., Cheng, J-Y., Chang, T-H., Lee, O. K-S. & Ho, J. H-C., Jan 1 2019, In : Biomaterials. 190-191, p. 1-10 10 p.

Research output: Contribution to journalArticle

Catenins
Cell Polarity
Stem cells
Mesenchymal Stromal Cells
Shear stress

Association of endothelin genetic variants and hospitalized infection complications in end-stage renal disease (ESRD) patients

Kao, C. C., Cheng, S. Y., Wang, Y. J., Chien, S. C., Hsu, Y. W., Wu, M. Y., Lu, H. F., Nam, S., Sun, T., Wu, M. S. & Chang, W. C., Jun 5 2019, In : BMC Nephrology. 20, 1, p. 203 203.

Research output: Contribution to journalArticle

Open Access
Endothelins
Chronic Kidney Failure
Bacteremia
Infection
Single Nucleotide Polymorphism
1 Citation (Scopus)

Cancers in Taiwan: Practical insight from epidemiology, treatments, biomarkers, and cost

Kuo, C. N., Liao, Y. M., Kuo, L. N., Tsai, H. J., Chang, W. C. & Yen, Y., Jan 1 2019, (Accepted/In press) In : Journal of the Formosan Medical Association.

Research output: Contribution to journalReview article

Open Access
Taiwan
Health Care Costs
Epidemiology
Biomarkers
Therapeutic Uses
4 Citations (Scopus)

Carboxylated carbon nanomaterials in cell cycle and apoptotic cell death regulation

Lee, K. C., Lo, P. Y., Lee, G. Y., Zheng, J. H. & Cho, E. C., Apr 20 2019, In : Journal of Biotechnology. 296, p. 14-21 8 p.

Research output: Contribution to journalArticle

Nanostructures
Cell death
Nanostructured materials
Cell Cycle
Cell Death

Characterization of T-Cell Receptor Repertoire in Patients with Rheumatoid Arthritis Receiving Biologic Therapies

Chang, C. M., Hsu, Y. W., Wong, H. S. C., Wei, J. C. C., Liu, X., Liao, H. T. & Chang, W. C., Jan 1 2019, In : Disease Markers. 2019, 1 p.

Research output: Contribution to journalArticle

Open Access
Biological Therapy
Antirheumatic Agents
T-Cell Antigen Receptor
Antigen Receptors, T-Cell, alpha-beta
Rheumatoid Arthritis

Combined Effects of MMP-7, MMP-8 and MMP-26 on the Risk of Ischemic Stroke

Hsieh, F-I., Chiou, H-Y., Hu, C-J., Jeng, J-S., Lin, H-J., Lee, J-T. & Lien, L-M., Nov 18 2019, In : Journal of Clinical Medicine. 8, 11

Research output: Contribution to journalArticle

Matrix Metalloproteinases
Stroke
Cardiovascular Diseases
Logistic Models
Causality

Doxorubicin conjugated AuNP/biopolymer composites facilitate cell cycle regulation and exhibit superior tumor suppression potential in KRAS mutant colorectal cancer

Hung, W. H., Zheng, J. H., Lee, K. C. & Cho, E. C., Dec 20 2019, In : Journal of Biotechnology. 306, p. 149-158 10 p.

Research output: Contribution to journalArticle

Biopolymers
Doxorubicin
Tumors
Colorectal Neoplasms
Cell Cycle

Endocytosis-dependent lysosomal degradation of Src induced by protease-activated receptor 1

Tsai, C. C., Kuo, F. T., Lee, S. B., Chang, Y. T. & Fu, H. W., Mar 1 2019, In : FEBS Letters. 593, 5, p. 504-517 14 p.

Research output: Contribution to journalArticle

PAR-1 Receptor
Endocytosis
Degradation
Chemical activation
Dynamins

Genetic loci determining total immunoglobulin E levels from birth through adulthood

Yao, T. C., Chung, R. H., Lin, C. Y., Tsai, P. C., Chang, W. C., Yeh, K. W., Tsai, M. H., Liao, S. L., Hua, M. C., Lai, S. H., Chen, L. C., Chang, S. W., Yu, Y. W., Hsu, J. Y., Chang, S. C., Cheng, W. C., Hu, D., Hong, X., Burchard, E. G., Wang, X. & 3 others, Tzeng, J. Y., Tsai, H. J. & Huang, J. L., Mar 1 2019, In : Allergy: European Journal of Allergy and Clinical Immunology. 74, 3, p. 621-625 5 p.

Research output: Contribution to journalLetter

Genetic Loci
Immunoglobulin E
Parturition

Genomic interrogation of familial short stature contributes to the discovery of the pathophysiological mechanisms and pharmaceutical drug repositioning

Wong, H. S. C., Lin, Y. J., Lu, H. F., Liao, W. L., Chen, C. H., Wu, J. Y., Chang, W. C. & Tsai, F. J., Nov 7 2019, In : Journal of Biomedical Science. 26, 1, 91.

Research output: Contribution to journalArticle

Open Access
Drug Repositioning
Genes
Pharmaceutical Preparations
Endocrine System
Genetic Loci
1 Citation (Scopus)

High accuracy differentiating autoimmune pancreatitis from pancreatic ductal adenocarcinoma by immunoglobulin G glycosylation

Shih, H. C., Chang, M. C., Chen, C. H., Tsai, I. L., Wang, S. Y., Kuo, Y. P., Chen, C. H. & Chang, Y. T., Jan 3 2019, In : Clinical Proteomics. 16, 1

Research output: Contribution to journalArticle

Open Access
Glycosylation
Pancreatitis
Adenocarcinoma
Immunoglobulin G
Regression Analysis

Host immune response to anti-cancer camptothecin conjugated cyclodextrin-based polymers

Chen, Y. F., Wang, Y. H., Lei, C. S., Changou, C. A., Davis, M. E. & Yen, Y., Oct 23 2019, In : Journal of Biomedical Science. 26, 1, 1 p.

Research output: Contribution to journalReview article

Open Access
Camptothecin
Cyclodextrins
Polymers
Neoplasms
Nanoparticles

HSPB1 rs2070804 polymorphism is associated with the depth of primary tumor

Hung, C. S., Huang, C. Y., Hsu, Y. W., Makondi, P. T., Chang, W. C., Chang, Y. J., Wang, J. Y. & Wei, P. L., Jan 1 2019, In : Journal of Cellular Biochemistry.

Research output: Contribution to journalArticle

Polymorphism
Tumors
Colorectal Neoplasms
Single Nucleotide Polymorphism
Neoplasms

Improved Dried Blood Spot-Based Metabolomics Analysis by a Postcolumn Infused-Internal Standard Assisted Liquid Chromatography-Electrospray Ionization Mass Spectrometry Method

Chepyala, D., Kuo, H. C., Su, K. Y., Liao, H. W., Wang, S. Y., Chepyala, S. R., Chang, L. C. & Kuo, C. H., Jan 1 2019, In : Analytical Chemistry.

Research output: Contribution to journalArticle

Electrospray ionization
Liquid chromatography
Mass spectrometry
Blood
Metabolites
Sleep
Cohort Studies
Brain Concussion
Brain Diseases
Traumatic Brain Injury

Loss of glycine n-methyltransferase associates with angiopoietin-like protein 8 expression in high fat-diet-fed mice

Huang, J. W., Chen, C. J., Yen, C. H., Chen, Y. M. A. & Liu, Y. P., Sep 1 2019, In : International Journal of Molecular Sciences. 20, 17, 4223.

Research output: Contribution to journalArticle

Open Access
Glycine N-Methyltransferase
Angiopoietins
diets
fats
Methyltransferases
1 Citation (Scopus)

Meta-Analysis of Genome-Wide Association Studies Identifies Three Loci Associated With Stiffness Index of the Calcaneus

Lu, H-F., Hung, K-S., Chu, H-W., Wong, H. S-C., Kim, J., Choi, B. Y., Kim, M. K., Tai, Y-T., Ikegawa, S., Cho, E-C. & Chang, W-C., Feb 19 2019, In : Journal of Bone and Mineral Research. p. e3703 e3703.

Research output: Contribution to journalArticle

Calcaneus
Genome-Wide Association Study
Single Nucleotide Polymorphism
Meta-Analysis
Taiwan
7 Citations (Scopus)

Metabolome analysis for investigating host-gut microbiota interactions

Chen, M. X., Wang, S. Y., Kuo, C. H. & Tsai, I. L., Mar 2019, In : Journal of the Formosan Medical Association.

Research output: Contribution to journalArticle

Metabolome
Mass Spectrometry
Metabolomics
Dysbiosis
Microbiota
1 Citation (Scopus)
Coumarins
Cell death
Colonic Neoplasms
Cell Death
Cells

Phthalate plasticizer di(2-ethyl-hexyl) phthalate induces cyclooxygenase-2 expression in gastric adenocarcinoma cells

Wong, J. H., Wang, Y. S., Nam, S., Ho, K. H., Chang, C. M., Chen, K. C., Chen, Y. F. & Chang, W. C., Jan 1 2019, In : Environmental Toxicology.

Research output: Contribution to journalArticle

Plasticizers
phthalate
Cyclooxygenase 2
Stomach
Adenocarcinoma

Single-nucleotide polymorphism of rs7944135 (macrophage-expressed gene 1) is associated with hepatitis B surface antigen seroclearance in chronic hepatitis B infection: A cohort study

Irham, L. M., Wong, H. S. C., Perwitasari, D. A., Chou, W. H., Yang, H. I. & Chang, W. C., Dec 1 2019, In : Medicine (United States). 98, 51, e17936.

Research output: Contribution to journalArticle

Open Access
Chronic Hepatitis B
Hepatitis B Surface Antigens
Single Nucleotide Polymorphism
Cohort Studies
Macrophages
2 Citations (Scopus)

Somatic mutations of PREX2 gene in patients with hepatocellular carcinoma

Yang, M. H., Yen, C. H., Chen, Y. F., Fang, C. C., Li, C. H., Lee, K. J., Lin, Y. H., Weng, C. H., Liu, T. T., Huang, S. F., Teh, B. T. & Chen, Y. M. A., Dec 1 2019, In : Scientific Reports. 9, 1, 2552.

Research output: Contribution to journalArticle

Open Access
Hepatocellular Carcinoma
Mutation
Genes
Protein Stability
Half-Life
Open Access
Brain Concussion
Somatomedins
Brain
Dizziness
Brain Injuries

The rs1256328 (ALPL) and rs12654812 (RGS14) Polymorphisms are Associated with Susceptibility to Calcium Nephrolithiasis in a Taiwanese population

Chen, W. C., Chou, W. H., Chu, H. W., Huang, C. C., Liu, X., Chang, W. P., Chou, Y. H. & Chang, W. C., Dec 1 2019, In : Scientific Reports. 9, 1, 17296.

Research output: Contribution to journalArticle

Open Access
GTP-Binding Protein Regulators
Nephrolithiasis
Alkaline Phosphatase
Calcium
Kidney

Transcriptomic and Proteomic Profiling of Human Mesenchymal Stem Cell Derived from Umbilical Cord in the Study of Preterm Birth

Chien, C. W., Lo, Y. S., Wu, H. Y., Hsuan, Y., Lin, C. K., Chen, Y. J., Lin, W. & Han, C. L., Jan 1 2019, (Accepted/In press) In : Proteomics - Clinical Applications. 1900024.

Research output: Contribution to journalArticle

Umbilical Cord
Premature Birth
Stem cells
Mesenchymal Stromal Cells
Proteomics

Tumor suppressor gene glycine N-methyltransferase and its potential in liver disorders and hepatocellular carcinoma

Chen, M., Yang, M. H., Chang, M. M., Tyan, Y. C. & Chen, Y. M. A., Sep 1 2019, In : Toxicology and Applied Pharmacology. 378, 114607.

Research output: Contribution to journalReview article

Glycine N-Methyltransferase
Tumor Suppressor Genes
Liver
Tumors
Hepatocellular Carcinoma
2 Citations (Scopus)

Utilizing proteomic approach to identify nuclear translocation related serine kinase phosphorylation site of GNMT as downstream effector for benzo[a]pyrene

Yang, M. H., Liao, C. C., Hung, J. H., Lai, X. T., Yen, C. H. & Chen, Y. M. A., Apr 1 2019, In : Journal of Food and Drug Analysis. 27, 2, p. 603-609 7 p.

Research output: Contribution to journalArticle

Open Access
glycine N-methyltransferase
Glycine N-Methyltransferase
Protein-Serine-Threonine Kinases
Benzo(a)pyrene
Proteomics
2018
2 Citations (Scopus)

Association between nonsteroidal anti-inflammatory drugs and atrial fibrillation among a middle-aged population: A nationwide population-based cohort

Chuang, S. Y., Hsu, P. F., Lin, F. J., Huang, Y. W., Wang, G. Z., Chang, W. C. & Tsai, H. J., Jan 1 2018, (Accepted/In press) In : British Journal of Clinical Pharmacology.

Research output: Contribution to journalArticle

Atrial Fibrillation
Anti-Inflammatory Agents
Pharmaceutical Preparations
Population
Odds Ratio
4 Citations (Scopus)

Association between nonsteroidal anti-inflammatory drugs and colorectal cancer: A population-based case-control study

Kuo, C. N., Pan, J. J., Huang, Y. W., Tsai, H. J. & Chang, W. C., Jul 1 2018, In : Cancer Epidemiology Biomarkers and Prevention. 27, 7, p. 737-745 9 p.

Research output: Contribution to journalArticle

Case-Control Studies
Colorectal Neoplasms
Anti-Inflammatory Agents
Pharmaceutical Preparations
Population
11 Citations (Scopus)
Protein-Tyrosine Kinases
Disease-Free Survival
Cytotoxic T-Lymphocytes
Bevacizumab
Myeloid-Derived Suppressor Cells

Cancer and mTOR inhibitors in kidney transplantation recipients

Kao, C. C., Liu, J. S., Chang, Y. K., Lin, M. H., Lin, Y. C., Chen, H. H., Chang, W. C., Hsu, C. C. & Wu, M. S., Jan 1 2018, In : PeerJ. 2018, 11, e5864.

Research output: Contribution to journalArticle

kidney transplant
Kidney Transplantation
neoplasms
Neoplasms
Hazards
3 Citations (Scopus)

Chemotherapy Immunophenoprofiles in Non-Small-Cell Lung Cancer by Personalized Membrane Proteomics

Putri, D. U., Feng, P. H., Hsu, Y. H., Lee, K. Y., Jiang, F. W., Kuo, L. W., Chen, Y. J. & Han, C. L., Jan 1 2018, (Accepted/In press) In : Proteomics - Clinical Applications.

Research output: Contribution to journalArticle

Pemetrexed
Chemotherapy
Non-Small Cell Lung Carcinoma
Proteomics
Cisplatin
Technology
Adenocarcinoma of lung
Myeloid-Derived Suppressor Cells

Integrative genomic analysis for the functional roles of ITPKC in bone mineral density

Lu, H. F., Wong, H. S. C., Chen, B. K., Liao, H. T., Hsu, Y. W., Ikegawa, S., Cho, E. C., Hung, K. S. & Chang, W. C., Nov 30 2018, In : Bioscience Reports. 38, 6, BSR20181481.

Research output: Contribution to journalArticle

Bone Density
Minerals
Bone
Genes
Osteoclasts
1 Citation (Scopus)
Medical Genetics
Chemokines
Cytokines
Tumor Microenvironment
Neoplasms
3 Citations (Scopus)

miR-4725-3p targeting stromal interacting molecule 1 signaling is involved in xanthohumol inhibition of glioma cell invasion

Ho, K. H., Chang, C. K., Chen, P. H., Wang, Y. J., Chang, W. C. & Chen, K. C., Aug 1 2018, In : Journal of Neurochemistry. 146, 3, p. 269-288 20 p.

Research output: Contribution to journalArticle

Glioma
Molecules
Glioblastoma
Humulus
Tumors
12 Citations (Scopus)

ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells

Chang, C. W., Chen, Y. S., Tsay, Y. G., Han, C. L., Chen, Y. J., Yang, C. C., Hung, K. F., Lin, C. H., Huang, T. Y., Kao, S. Y., Lee, T. C. & Lo, J. F., Feb 1 2018, In : Cell Death and Disease. 9, 2, 194.

Research output: Contribution to journalArticle

Neoplasms
Maintenance
Acetyl Coenzyme A
Citric Acid Cycle
Neoplastic Stem Cells
5 Citations (Scopus)

S100A9+ MDSC and TAM-mediated EGFR-TKI resistance in lung adenocarcinoma: The role of RELB

Feng, P. H., Yu, C. T., Chen, K. Y., Luo, C. S., Wu, S. M., Liu, C. Y., Kuo, L. W., Chan, Y. F., Chen, T. T., Chang, C. C., Lee, C. N., Chuang, H. C., Lin, C. F., Han, C. L., Lee, W. H. & Lee, K. Y., Jan 26 2018, In : Oncotarget. 9, 7, p. 7631-7643 13 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Macrophages
Microarray Analysis
Blood Cells
Alveolar Macrophages
HSP27 Heat-Shock Proteins
Colorectal Neoplasms
Neoplasm Metastasis
Molecules
Proteins
6 Citations (Scopus)

Subcellular Proteome Landscape of Human Embryonic Stem Cells Revealed Missing Membrane Proteins

Weldemariam, M. M., Han, C-L., Shekari, F., Kitata, R. B., Chuang, C-Y., Hsu, W-T., Kuo, H-C., Choong, W-K., Sung, T-Y., He, F-C., Chung, M. C. M., Salekdeh, G. H. & Chen, Y-J., Dec 7 2018, In : Journal of Proteome Research. 17, 12, p. 4138-4151 14 p.

Research output: Contribution to journalArticle

Proteome
Stem cells
Membrane Proteins
Proteins
Peptides
6 Citations (Scopus)

The association between BDNF Val66Met polymorphism and emotional symptoms after mild traumatic brain injury

Wang, Y. J., Chen, K. Y., Kuo, L. N., Wang, W. C., Hsu, Y. W., Wong, H. S. C., Lin, C. M., Liao, K. H., Zhang, Y. F., Chiang, Y. H. & Chang, W. C., Jan 22 2018, In : BMC Medical Genetics. 19, 1, 13.

Research output: Contribution to journalArticle

Brain Concussion
Brain-Derived Neurotrophic Factor
Equipment and Supplies
Alleles
Depression
5 Citations (Scopus)

Tousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitors

Lee, S. B., Segura-Bayona, S., Villamor-Payà, M., Saredi, G., Todd, M. A. M., Attolini, C. S. O., Chang, T. Y., Stracker, T. H. & Groth, A., Aug 8 2018, In : Science advances. 4, 8, eaat4985.

Research output: Contribution to journalArticle

Adenosine
Phosphotransferases
Chromatin Assembly and Disassembly
Nucleosomes
DNA Replication
5 Citations (Scopus)

Transforming growth factor alpha promotes tumorigenesis and regulates epithelial-mesenchymal transition modulation in colon cancer

Yu, C. Y., Chang, W. C., Zheng, J. H., Hung, W. H. & Cho, E. C., Dec 2 2018, In : Biochemical and Biophysical Research Communications. 506, 4, p. 901-906 6 p.

Research output: Contribution to journalArticle

Transforming Growth Factor alpha
Epithelial-Mesenchymal Transition
Colonic Neoplasms
Assays
Carcinogenesis
9 Citations (Scopus)

β-Amyloid Induces Pathology-Related Patterns of Tau Hyperphosphorylation at Synaptic Terminals

Wu, H-Y., Kuo, P-C., Wang, Y-T., Lin, H-T., Roe, A. D., Wang, B. Y., Han, C-L., Hyman, B. T., Chen, Y-J. & Tai, H-C., Sep 1 2018, In : Journal of Neuropathology and Experimental Neurology. 77, 9, p. 814-826 13 p.

Research output: Contribution to journalArticle

Presynaptic Terminals
Amyloid
Phosphotransferases
Proline
Pathology
2017
1 Citation (Scopus)

Associations of genetic variants of endothelin with cardiovascular complications in patients with renal failure

Kao, C. C., Cheng, S. Y., Wu, M. Y., Chien, S. C., Lu, H. F., Hsu, Y. W., Zhang, Y. F., Wu, M. S. & Chang, W. C., Sep 7 2017, In : BMC Nephrology. 18, 1, 291.

Research output: Contribution to journalArticle

Endothelins
Renal Insufficiency
Chronic Kidney Failure
Genes
Tibial Arteries
6 Citations (Scopus)

Correlation of HAMP gene polymorphisms and expression with the susceptibility and length of hospital stays in Taiwanese children with Kawasaki disease

Huang, Y. H., Yang, K. D., Hsu, Y. W., Lu, H. F., Wong, H. S. C., Yu, H. R., Kuo, H. C., Huang, F. C., Lo, M. H., Hsieh, K. S., Chen, S. F., Chang, W. C. & Kuo, H. C., Feb 7 2017, In : Oncotarget. 8, 31, p. 51859-51868 10 p.

Research output: Contribution to journalArticle

Mucocutaneous Lymph Node Syndrome
Hepcidins
Length of Stay
Intravenous Immunoglobulins
Gene Expression
3 Citations (Scopus)

CYP2E1 Gene Polymorphisms Related to the Formation of Coronary Artery Lesions in Kawasaki Disease

Chang, L. S., Hsu, Y. W., Lu, C. C., Lo, M. H., Hsieh, K. S., Li, S. C., Chang, W. C. & Kuo, H. C., Nov 1 2017, In : Pediatric Infectious Disease Journal. 36, 11, p. 1039-1043 5 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2E1
Mucocutaneous Lymph Node Syndrome
Coronary Vessels
Genes
Single Nucleotide Polymorphism
4 Citations (Scopus)

Exposure to tobacco smoke and childhood rhinitis: A population-based study

Yao, T. C., Chang, S. W., Chang, W. C., Tsai, M. H., Liao, S. L., Hua, M. C., Lai, S. H., Yeh, K. W., Tseng, Y. L., Lin, W. C., Tsai, H. J. & Huang, J. L., Feb 16 2017, In : Scientific Reports. 7, 42836.

Research output: Contribution to journalArticle

Rhinitis
Smoke
Tobacco
Cotinine
Population
6 Citations (Scopus)

Identification of genes and pathways related to lymphovascular invasion in breast cancer patients: A bioinformatics analysis of gene expression profiles

Klahan, S., Wong, H. S. C., Tu, S. H., Chou, W. H., Zhang, Y. F., Ho, T. F., Liu, C. Y., Yih, S. Y., Lu, H. F., Chen, S. C. C., Huang, C. C. & Chang, W. C., Jan 1 2017, In : Tumor Biology. 39, 6

Research output: Contribution to journalArticle

Computational Biology
Transcriptome
Breast Neoplasms
Genes
Microarray Analysis