Graduate Institute of Pharmacognosy

  • No. 250 Wu-Xing Street

    11031 Taipei

Research Output 1988 2019

Filter
Article
2019
Open Access
oxygen radical absorbance capacity
glycation
hemolysis
galactose
oxidative stress

Development of an inflammatory tissue-selective chimeric TNF receptor

Lee, C. J., Wang, C. C., Chen, M., Chuang, K. H., Cheng, T. L., Jian, T. Y., Wang, Y. M., Huang, T. H., Liao, K. W. & Tzou, S. C., Jan 1 2019, In : Cytokine. 113, p. 340-346 7 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptors
Matrix Metalloproteinases
Tissue
Substrates
Binding Sites

Efficient identification of fungal antimicrobial principles by tandem MS and NMR database

Lee, M. S., Yang, Y. L., Wu, C. Y., Chen, Y. L., Lee, C. K., Tzean, S. S. & Lee, T. H., Jan 1 2019, In : Journal of Food and Drug Analysis.

Research output: Contribution to journalArticle

Open Access
nuclear magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy
anti-infective agents
High Pressure Liquid Chromatography
Databases

Elucidation of the Effects of Si-Wu Tang on Menstrual Disorder Patterns through Activation of Aromatase and Antioxidation

Huang, G. C., Tsai, Y. Z., Lee, C. J., Chang, H. Y. & Wang, C. C., Mar 6 2019, In : Evidence-based Complementary and Alternative Medicine. 2019, p. 4761651 8 p., 4761651.

Research output: Contribution to journalArticle

Open Access
Rehmannia
Aromatase
ferulic acid
Polyphenols
Estradiol

HDAC8 inhibitor WK2-16 therapeutically targets lipopolysaccharide-induced mouse model of neuroinflammation and microglial activation

Lin, F. L., Yen, J. L., Kuo, Y. C., Kang, J. J., Cheng, Y. W., Huang, W. J. & Hsiao, G., Jan 2 2019, In : International Journal of Molecular Sciences. 20, 2, p. 410 410.

Research output: Contribution to journalArticle

Neuroglia
inhibitors
mice
Lipopolysaccharides
Chemical activation

In situ chemically crosslinked injectable hydrogels for the subcutaneous delivery of trastuzumab to treat breast cancer

Lo, Y. W., Sheu, M. T., Chiang, W. H., Chiu, Y. L., Tu, C. M., Wang, W. Y., Wu, M. H., Wang, Y. C., Lu, M. & Ho, H. O., Mar 1 2019, In : Acta Biomaterialia. 86, p. 280-290 11 p.

Research output: Contribution to journalArticle

Hydrogels
Hydrogel
Breast Neoplasms
Injections
Antibodies

Isolated compounds from turpinia formosana nakai induce ossification

Imtiyaz, Z., Wang, Y. F., Lin, Y. T., Liu, H. K. & Lee, M. H., Jul 1 2019, In : International Journal of Molecular Sciences. 20, 13, 3119.

Research output: Contribution to journalArticle

Open Access
osteogenesis
Osteogenesis
Bone
bones
osteoblasts
1 Citation (Scopus)

Isoprenyl phenolic ethers from the termite nest-derived medicinal fungus Xylaria fimbriata

Chen, M. C., Wang, G. J., Kuo, Y. H., Chiang, Y. R., Cho, T. Y., Ju, Y. M. & Lee, T. H., Jan 1 2019, In : Journal of Food and Drug Analysis. 27, 1, p. 111-117 7 p.

Research output: Contribution to journalArticle

Open Access
Xylaria
Isoptera
termite mounds
Ethers
nitric oxide

Liposomal irinotecan for treatment of colorectal cancer in a preclinical model

Huang, J. R., Lee, M. H., Li, W. S. & Wu, H. C., Mar 1 2019, In : Cancers. 11, 3, 281.

Research output: Contribution to journalArticle

Open Access
irinotecan
Colorectal Neoplasms
Therapeutics
Gastrointestinal Contents

Low-luminance blue light-enhanced phototoxicity in A2E-Laden RPE cell cultures and rats

Lin, C. H., Wu, M. R., Huang, W. J., Chow, D. S. L., Hsiao, G. & Cheng, Y. W., Apr 1 2019, In : International Journal of Molecular Sciences. 20, 7, 1799.

Research output: Contribution to journalArticle

Open Access
Phototoxic Dermatitis
Retinal Pigments
luminance
pigments
Cell culture
Neoplastic Stem Cells
Endometriosis
Mesenchymal Stromal Cells
Estradiol
Stem Cells

New abietane-type diterpenoids from the bark of cryptomeria japonica

Chang, C. I., Chen, J. J., Hsu, C., Chen, C. C., Cheng, W. Y., Wang, S. Y., Lee, C. K., Cheng, M. J. & Kuo, Y. H., Jan 1 2019, In : Natural Product Communications. 14, 1, p. 97-100 4 p.

Research output: Contribution to journalArticle

Abietane Diterpenes
Cryptomeria
xanthine oxidase
Cryptomeria japonica
Xanthine Oxidase

Specific activation of pro-Infliximab enhances selectivity and safety of rheumatoid arthritis therapy

Lu, Y. C., Chuang, C. H., Chuang, K. H., Chen, I. J., Huang, B. C., Lee, W. H., Wang, H. E., Li, J. J., Cheng, Y. A., Cheng, K. W., Wang, J. Y., Hsieh, Y. C., Lin, W. W. & Cheng, T. L., Jun 1 2019, In : PLoS Biology. 17, 6, p. e3000286

Research output: Contribution to journalArticle

Open Access
rheumatoid arthritis
Rheumatoid Arthritis
Chemical activation
Safety
therapeutics

Stability of Principal Hydrolysable Tannins from Trapa taiwanensis Hulls

Wang, C. C., Chen, H. F., Wu, J. Y. & Chen, L. G., Jan 21 2019, In : Molecules. 24, 2, 365.

Research output: Contribution to journalArticle

Open Access
Hydrolyzable Tannins
fluids
antioxidants
Fluids
buffers
2018
Dioscorea
Glucose Intolerance
dipeptides
Dipeptides
yams
3 Citations (Scopus)

4-O-Caffeoylquinic acid as an antioxidant marker for mulberry leaves rich in phenolic compounds

Ganzon, J. G., Chen, L. G. & Wang, C. C., 2018, In : Journal of Food and Drug Analysis.

Research output: Contribution to journalArticle

Morus
mulberries
phenolic compounds
Antioxidants
antioxidants

A novel hydroxamate-based compound WMJ-J-09 causes head and neck squamous cell carcinoma cell death via LKB1-AMPK-p38MAPK-p63-survivin cascade

Yen, C. S., Choy, C. S., Huang, W. J., Huang, S. W., Lai, P. Y., Yu, M. C., Shiue, C., Hsu, Y. F. & Hsu, M. J., Mar 1 2018, In : Frontiers in Pharmacology. 9, MAR, p. 1-17 17 p., 167.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Cell Death
Microtubules
Liver
Phosphorylation
4 Citations (Scopus)
docetaxel
Bispecific Antibodies
Lecithins
Drug Delivery Systems
Neoplasms
3 Citations (Scopus)

Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) promotes EGF receptor signaling of oral squamous cell carcinoma metastasis via the complex N-glycosylation

Chiang, W. F., Cheng, T. M., Chang, C. C., Pan, S. H., Changou, C. A., Chang, T. H., Lee, K. H., Wu, S. Y., Chen, Y. F., Chuang, K. H., Shieh, D. B., Chen, Y. L., Tu, C. C., Tsui, W. L. & Wu, M. H., Jan 4 2018, In : Oncogene. 37, 1, p. 116-127 12 p.

Research output: Contribution to journalArticle

Carcinoembryonic Antigen
Cell Adhesion Molecules
Glycosylation
Epidermal Growth Factor Receptor
Squamous Cell Carcinoma
5 Citations (Scopus)

Cerebellar α6-subunit-containing GABAA receptors: a novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders

Chiou, L-C., Lee, H-J., Ernst, M., Huang, W-J., Chou, J-F., Chen, H-L., Mouri, A., Chen, L-C., Treven, M., Mamiya, T., Fan, P-C., Knutson, D. E., Witzigmann, C., Cook, J., Sieghart, W. & Nabeshima, T., 2018, In : British Journal of Pharmacology. 175, 12, p. 2414-2427 14 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Methamphetamine
Sensory Gating
Furosemide
Startle Reflex
2 Citations (Scopus)

Design of diarylheptanoid derivatives as dual inhibitors against class IIa histone deacetylase and β-amyloid aggregation

Chen, L. C., Tseng, H. J., Liu, C. Y., Huang, Y. Y., Yen, C. C., Weng, J. R., Lu, Y. L., Hou, W. C., Lin, T. E., Pan, I. H., Huang, K. K., Huang, W. J. & Hsu, K. C., Jul 3 2018, In : Frontiers in Pharmacology. 9, JUL, 708.

Research output: Contribution to journalArticle

Diarylheptanoids
Histone Deacetylases
Amyloid
Alzheimer Disease
Pyrogallol
8 Citations (Scopus)
docetaxel
Lecithins
Drug Delivery Systems
Therapeutics
Neoplasms
2 Citations (Scopus)

Development of a highly sensitive enzyme-linked immunosorbent assay (ELISA) through use of poly-protein G-expressing cell-based microplates

Chen, Y. J., Chen, M., Hsieh, Y. C., Su, Y. C., Wang, C. H., Cheng, C. M., Kao, A. P., Wang, K. H., Cheng, J. J. & Chuang, K. H., Dec 1 2018, In : Scientific Reports. 8, 1, 17868.

Research output: Contribution to journalArticle

Poly G
Gastrin-Secreting Cells
Enzyme-Linked Immunosorbent Assay
Antibodies
Proteins
7 Citations (Scopus)

Discovery of aliphatic-chain hydroxamates containing indole derivatives with potent class I histone deacetylase inhibitory activities

Chao, S. W., Chen, L. C., Yu, C. C., Liu, C. Y., Lin, T. E., Guh, J. H., Wang, C. Y., Chen, C. Y., Hsu, K. C. & Huang, W. J., Jan 1 2018, In : European Journal of Medicinal Chemistry. 143, p. 792-805 14 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Derivatives
Carbon
Molecular Docking Simulation
Cutaneous T-Cell Lymphoma

Genomic Alterations of Extrectra Cellular Genes as Diagnosis Markers for Head and Neck Squamous Cell Carcinoma

Yang, C-H., Lin, R-D., Lee, M-H., Tsai, M-H. & Su, L-J., 2018, In : International Journal of Head and Neck Science. 2, 1, p. 21-24 4 p.

Research output: Contribution to journalArticle

Head and Neck Neoplasms
Genes
Computational Biology
Squamous Cell Carcinoma
Public Health
1 Citation (Scopus)
Open Access
Oxidative Stress
Acetaminophen
Liver
Wounds and Injuries
Hep G2 Cells
1 Citation (Scopus)

Hypermethylation of CCND2 in Lung and Breast Cancer Is a Potential Biomarker and Drug Target

Hung, C. S., Wang, S. C., Yen, Y. T., Lee, T. H., Wen, W. C. & Lin, R. K., Oct 10 2018, In : International Journal of Molecular Sciences. 19, 10

Research output: Contribution to journalArticle

biomarkers
Biomarkers
breast
lungs
Lung Neoplasms
1 Citation (Scopus)

Inhibitory effects of punicalagin from Punica granatum against type II collagenase-induced osteoarthritis

Lee, C. J., Chen, L. G., Liang, W. L., Hsieh, M. S. & Wang, C. C., Feb 1 2018, In : Journal of Functional Foods. 41, p. 216-222 7 p.

Research output: Contribution to journalArticle

Punicaceae
Punica granatum
collagenase
chondrocytes
osteoarthritis
3 Citations (Scopus)

In vitro and in vivo anti-osteoarthritis effects of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside from Polygonum multiflorum

Tsai, P. W., Lee, Y. H., Chen, L. G., Lee, C. J. & Wang, C. C., Jan 1 2018, In : Molecules. 23, 3, 571.

Research output: Contribution to journalArticle

prostaglandins
glucosides
nitric oxide
Dinoprostone
Osteoarthritis
1 Citation (Scopus)
Lecithins
Quercetin
Micelles
Therapeutic Uses
Doxorubicin
1 Citation (Scopus)

New Hirsutinolide-Type Sesquiterpenoids from Vernonia cinerea Inhibit Nitric Oxide Production in LPS-Stimulated RAW264.7 Cells

Kuo, L. M. Y., Tseng, P. Y., Lin, Y. C., Liaw, C. C., Zhang, L. J., Tsai, K. C., Lin, Z. H., Ho, H. O. & Kuo, Y. H., Jul 9 2018, (Accepted/In press) In : Planta Medica.

Research output: Contribution to journalArticle

Vernonia
Phytochemicals
Structure-Activity Relationship
Nitric Oxide
Esters
6 Citations (Scopus)
docetaxel
Poloxamer
Lecithins
Ovarian Neoplasms
Cisplatin
3 Citations (Scopus)
Clustered Regularly Interspaced Short Palindromic Repeats
Polyethyleneimine
Cell death
Serum Albumin
Immunotherapy
1 Citation (Scopus)
Antrodia
Cell growth
Drug Resistance
lungs
Cell Movement
2 Citations (Scopus)

Suppressive activities and mechanisms of ugonin J on vascular smooth muscle cells and balloon angioplasty-induced neointimal hyperplasia

Pan, C. H., Li, P. C., Chien, Y. C., Yeh, W. T., Liaw, C. C., Sheu, M. J. & Wu, C. H., 2018, In : Phytotherapy Research.

Research output: Contribution to journalArticle

Balloon Angioplasty
Vascular Smooth Muscle
Smooth Muscle Myocytes
Hyperplasia
Cell Movement
6 Citations (Scopus)
Glucosides
Doxorubicin
antioxidant
Antioxidants
Focal Segmental Glomerulosclerosis
2017
8 Citations (Scopus)

A histone deacetylase inhibitor enhances expression of genes inhibiting Wnt pathway and augments activity of DNA demethylation reagent against nonsmall-cell lung cancer

Shieh, J. M., Tang, Y. A., Hu, F. H., Huang, W. J., Wang, Y. J., Jen, J., Liao, S. Y., Lu, Y. H., Yeh, Y. L., Wang, T. W., Lin, P. & Wang, Y. C., May 15 2017, In : International Journal of Cancer. 140, 10, p. 2375-2386 12 p.

Research output: Contribution to journalArticle

decitabine
Wnt Signaling Pathway
Histone Deacetylase Inhibitors
Histone Deacetylases
Non-Small Cell Lung Carcinoma
4 Citations (Scopus)

A novel histone deacetylase inhibitor TMU-35435 enhances etoposide cytotoxicity through the proteasomal degradation of DNA-PKcs in triple-negative breast cancer

Wu, Y. H., Hong, C. W., Wang, Y. C., Huang, W. J., Yeh, Y. L., Wang, B. J., Wang, Y. J. & Chiu, H. W., Aug 1 2017, In : Cancer Letters. 400, p. 79-88 10 p.

Research output: Contribution to journalArticle

DNA-Activated Protein Kinase
Triple Negative Breast Neoplasms
Histone Deacetylase Inhibitors
Etoposide
DNA Repair
1 Citation (Scopus)
Amine Oxidase (Copper-Containing)
Hydroxyurea
Diabetes Complications
Inhibitory Concentration 50
Cardiovascular Diseases
14 Citations (Scopus)

Bioactive constituents from the termite nest-derived medicinal fungus Xylaria nigripes

Chang, J. C., Hsiao, G., Lin, R. K., Kuo, Y. H., Ju, Y. M. & Lee, T. H., Jan 27 2017, In : Journal of Natural Products. 80, 1, p. 38-44 7 p.

Research output: Contribution to journalArticle

Isoptera
Fungi
Alcohols
Sleep Initiation and Maintenance Disorders
Nitric Oxide Synthase Type II
3 Citations (Scopus)
Eriobotrya
fibroblasts
ultraviolet radiation
leaves
Fibroblasts
12 Citations (Scopus)

Conditional internalization of PEGylated nanomedicines by PEG engagers for triple negative breast cancer therapy

Su, Y. C., Burnouf, P. A., Chuang, K. H., Chen, B. M., Cheng, T. L. & Roffler, S. R., Jun 8 2017, In : Nature Communications. 8, 15507.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Nanomedicine
Medical nanotechnology
Epidermal Growth Factor Receptor
breast
Ovalbumin
Medicine
Inflammation
Microbiology
Allergy and Immunology
1 Citation (Scopus)
docetaxel
Pharmacokinetics
Ultrafiltration
Plasmas
Micelles

Hypermethylation of BEND5 contributes to cell proliferation and is a prognostic marker of colorectal cancer

Lin, R. K., Hung, W. Y., Huang, Y. F., Chang, Y. J., Lin, C. H., Chen, W. Y., Chiu, S. F., Chang, S. C. & Tsai, S. F., Jan 1 2017, In : Oncotarget. 8, 69, p. 113431-113443 13 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Cell Proliferation
Tumor Suppressor Genes
Taiwan
Survival
1 Citation (Scopus)

Intermedin A, a New Labdane Diterpene Isolated from Alpinia intermedia, Prolonged the Survival Time of P-388D1 Tumor-Bearing CDF1 Mice

Chen, L. G., Su, P. J., Tsai, P. W., Yang, L. L. & Wang, C. C., 2017, In : Planta Medica.

Research output: Contribution to journalArticle

Bearings (structural)
Alpinia
Diterpenes
Tumors
HL-60 Cells
6 Citations (Scopus)

Monoamine oxidase A is highly expressed in classical Hodgkin lymphoma

Li, P. C., Siddiqi, I. N., Mottok, A., Loo, E. Y., Wu, C. H., Cozen, W., Steidl, C. & Shih, J. C., Oct 1 2017, In : Journal of Pathology. 243, 2, p. 220-229 10 p.

Research output: Contribution to journalArticle

Monoamine Oxidase
Hodgkin Disease
Lymphoma
Clorgyline
Non-Hodgkin's Lymphoma
6 Citations (Scopus)

Multiple activities of punica granatum linne against acne vulgaris

Lee, C-J., Chen, L. G., Liang, W-L. & Wang, C-C., Jan 12 2017, In : International Journal of Molecular Sciences. 18, 1, 141.

Research output: Contribution to journalArticle

Punicaceae
Acne Vulgaris
Lipases
Lipase
Hydrolyzable Tannins
11 Citations (Scopus)

Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach

Hsu, K. C., Liu, C. Y., Lin, T. E., Hsieh, J. H., Sung, T. Y., Tseng, H. J., Yang, J. M. & Huang, W. J., Dec 1 2017, In : Scientific Reports. 7, 1, 3228.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Histone Deacetylases
Computer Simulation
Protein Isoforms
Enzymes